The Adaptor Protein Fish Associates with Members of the ADAMs Family and Localizes to Podosomes of Src-transformed Cells

Name: Work Video:
Duration: 3 min 30 s
Clare L. Abram; Darren F. Seals; Ian Pass; Daniel Salinsky; Lisa M. Maurer; Therese M. Roth; Sara A. Courtneidge
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63, 83, 223, 278, 282, 302, 442, 582, 838, 1734, 1820, 2061, 2104, 2675, 3297, 3331, 3346, 3410, 3423, 3518, 3591, 3728, 3760, 3869, 3950, 4490], 'and': [5, 16, 32, 51, 64, 126, 145, 172, 201, 224, 235, 251, 270, 283, 345, 364, 391, 420, 496, 520, 523, 534, 552, 589, 617, 635, 655, 701, 784, 851, 913, 931, 951, 1029, 1101, 1207, 1236, 1321, 1382, 1433, 1536, 1549, 1589, 1600, 1634, 1819, 1829, 1849, 1866, 1910, 1922, 1946, 1961, 1988, 2006, 2048, 2063, 2160, 2202, 2217, 2239, 2251, 2280, 2315, 2332, 2334, 2369, 2438, 2544, 2553, 2594, 2645, 2688, 2700, 2722, 2773, 2797, 2804, 2814, 2828, 2848, 2858, 2895, 2938, 2965, 3121, 3130, 3143, 3266, 3316, 3349, 3361, 3413, 3445, 3484, 3684, 3798, 3834, 3853, 3880, 3904, 3920, 3928, 3958, 3992, 4025, 4044, 4076, 4136, 4211, 4216, 4247, 4293, 4298, 4329, 4350, 4375, 4413], 'Src': [6, 18, 213, 225, 237, 432, 452, 468, 946], 'substrate.': [7, 226], 'It': [8, 227, 488, 1423, 2974], 'contains': [9, 228, 1446, 1563, 2083, 2607], 'an': [10, 208, 229, 427, 565, 2482, 2521, 2955], 'amino-terminal': [11, 230], 'Phox': [12, 231], 'homology': [13, 19, 232, 238, 439, 453], '(PX)': [14, 233], 'domain': [15, 42, 68, 91, 122, 142, 234, 261, 287, 310, 341, 361, 767, 783, 793, 830, 857, 915, 923, 1848, 1853, 2033, 2066, 2079, 2158, 2163, 3107, 3120, 3125, 3217, 3260, 3305, 3419, 3447, 3455, 3499, 3579, 3695, 3749, 3769, 3818, 3847, 3875, 3889, 3937, 3979], 'five': [17, 236, 497], '3': [20, 239, 2766], '(SH3)': [21, 240], 'domains,': [22, 241, 499, 512, 640, 1822, 4057, 4412], 'as': [23, 25, 148, 196, 198, 207, 242, 244, 367, 415, 417, 426, 500, 502, 543, 586, 641, 1023, 1582, 1595, 1597, 1726, 1862, 1864, 2375, 2491, 2662, 2865, 3203, 3205, 4194, 4276], 'well': [24, 197, 243, 416, 501, 1596, 1863, 3204], 'multiple': [26, 245, 503, 1564], 'motifs': [27, 246, 505, 535, 1566], 'for': [28, 247, 517, 549, 936, 1628, 1635, 1809, 1920, 1983, 2241, 2317, 2356, 2516, 2679, 2691, 2740, 2906, 2927, 2935, 3774, 4224, 4306], 'binding': [29, 150, 248, 369, 668, 690, 822, 853, 916, 1810, 1821, 1827, 3150, 3228, 3269, 3870, 3912, 3924, 3932, 3961, 3974, 4441], 'both': [30, 124, 249, 343, 518, 550, 927, 948, 1825, 3443, 3469, 3851], 'SH2': [31, 250], 'SH3': [33, 141, 252, 360, 498, 511, 587, 747, 792, 821, 852, 914, 1573, 1610, 1852, 2036, 2157, 3888, 3936, 3978, 4066, 4460], 'domain-containing': [34, 253, 1574], 'proteins.': [35, 254, 1575], 'We': [36, 132, 255, 351, 939, 1856, 3194, 3283, 3293, 3308, 3324, 3507, 3593, 3606, 3764, 3807, 3952, 3965, 4019], 'have': [37, 189, 256, 408, 638, 674, 1107, 1312, 1533, 1643, 1723, 1805, 1857, 3093, 3144, 3637], 'determined': [38, 257, 2492, 3317, 3799], 'that': [39, 88, 158, 211, 258, 307, 377, 430, 506, 539, 645, 731, 740, 773, 820, 908, 942, 992, 1031, 1062, 1106, 1177, 1185, 1200, 1308, 1367, 1417, 1539, 1567, 1606, 1745, 1843, 3089, 3213, 3366, 3450, 3495, 3800, 4059, 4078, 4482], 'the': [40, 65, 80, 120, 139, 165, 186, 259, 284, 299, 339, 358, 384, 405, 615, 621, 652, 662, 765, 779, 782, 790, 825, 836, 855, 932, 997, 1038, 1089, 1096, 1099, 1160, 1164, 1305, 1365, 1429, 1438, 1449, 1557, 1570, 1578, 1609, 1629, 1652, 1657, 1729, 1732, 1750, 1764, 1770, 1783, 1787, 1794, 1839, 1846, 1850, 1949, 1976, 1991, 2021, 2031, 2058, 2064, 2102, 2133, 2155, 2161, 2170, 2195, 2222, 2282, 2302, 2420, 2442, 2454, 2513, 2659, 2671, 2727, 2730, 2807, 2812, 2849, 2962, 3094, 3104, 3116, 3214, 3257, 3288, 3303, 3330, 3350, 3417, 3421, 3451, 3480, 3488, 3496, 3512, 3515, 3534, 3571, 3574, 3577, 3596, 3617, 3620, 3693, 3700, 3736, 3747, 3767, 3777, 3825, 3838, 3845, 3859, 3894, 3898, 3931, 3940, 3943, 3960, 3976, 3995, 4060, 4101, 4132, 4137, 4141, 4200, 4212, 4221, 4230, 4240, 4245, 4248, 4255, 4258, 4282, 4294, 4303, 4312, 4322, 4327, 4330, 4337, 4340, 4346, 4363, 4367, 4372, 4439, 4458, 4472, 4475, 4499], 'PX': [41, 67, 90, 121, 260, 286, 309, 340, 554, 628, 639, 672, 679, 696, 722, 766, 829, 848, 856, 922, 1847, 2032, 2065, 2078, 2162, 3091, 3106, 3119, 3124, 3141, 3154, 3216, 3259, 3304, 3454, 3483, 3498, 3536, 3578, 3694, 3748, 3768, 3817, 3846], 'of': [43, 60, 111, 143, 164, 185, 262, 279, 330, 362, 383, 404, 531, 560, 595, 620, 625, 670, 733, 764, 768, 781, 794, 827, 924, 989, 996, 1004, 1088, 1098, 1163, 1192, 1209, 1229, 1377, 1431, 1434, 1444, 1453, 1556, 1577, 1612, 1631, 1660, 1731, 1772, 1775, 1785, 1796, 1802, 1812, 1817, 1841, 1854, 1939, 1952, 1957, 1994, 1999, 2010, 2016, 2028, 2057, 2067, 2101, 2136, 2165, 2330, 2344, 2468, 2486, 2496, 2520, 2524, 2541, 2550, 2586, 2624, 2630, 2658, 2670, 2712, 2737, 2756, 2759, 2768, 2840, 2909, 3115, 3249, 3291, 3299, 3306, 3329, 3347, 3411, 3416, 3420, 3431, 3482, 3514, 3522, 3560, 3562, 3573, 3580, 3599, 3611, 3614, 3633, 3688, 3703, 3716, 3750, 3770, 3776, 3796, 3813, 3848, 3861, 3883, 3911, 3930, 3934, 3942, 3946, 3948, 3963, 3980, 4030, 4035, 4100, 4104, 4108, 4134, 4148, 4150, 4154, 4202, 4205, 4220, 4239, 4257, 4284, 4287, 4302, 4321, 4339, 4366, 4447, 4457, 4462, 4474], 'binds': [45, 264], '3-phosphorylated': [46, 265], 'phosphatidylinositols': [47, 266], '(including': [48, 267, 661], 'phosphatidylinositol': [49, 52, 268, 271, 444, 447, 685, 704, 3099], '3-phosphate': [50, 269, 445], '3,4-bisphosphate).': [53, 272], 'Consistent': [54, 273], 'with': [55, 138, 161, 179, 274, 357, 380, 398, 510, 564, 581, 597, 987, 1007, 1019, 1456, 1572, 1728, 1755, 1845, 1929, 2273, 2348, 2409, 2436, 2481, 2538, 2546, 2559, 2583, 2667, 2718, 2734, 2765, 2778, 2800, 2855, 2940, 2969, 3127, 3199, 3247, 3339, 3343, 3374, 3407, 3442, 3462, 3503, 3550, 3588, 3627, 3711, 3756, 3791, 3878, 3897, 4055, 4083, 4390, 4468, 4487, 4493], 'this,': [56, 275], 'fusion': [58, 277, 2093, 2283, 2351, 2674, 3113, 3345, 3409, 3876], 'green': [61, 280, 440, 2059], 'fluorescent': [62, 281, 441, 2060, 2958], 'localized': [69, 288], 'to': [70, 74, 96, 115, 128, 214, 289, 293, 315, 334, 347, 433, 466, 683, 745, 787, 789, 832, 854, 859, 1017, 1034, 1172, 1527, 1608, 1616, 1648, 1807, 1935, 2176, 2236, 2257, 2294, 2301, 2309, 2354, 2453, 2465, 2488, 2703, 2753, 2806, 2824, 3096, 3133, 3147, 3211, 3219, 3224, 3231, 3264, 3271, 3279, 3281, 3286, 3302, 3460, 3473, 3478, 3510, 3533, 3585, 3619, 3686, 3722, 3780, 3824, 3830, 3832, 3855, 3858, 3967, 3971, 3975, 4064, 4081, 4097, 4183, 4407, 4425, 4427, 4450, 4466, 4510], 'punctate': [71, 290, 3327, 3334, 3428, 3439, 3563, 3731], 'structures': [72, 117, 291, 336, 1105, 1187, 1369, 1386], 'similar': [73, 292], 'endosomes': [75, 294, 3433], 'in': [76, 100, 154, 181, 192, 295, 319, 373, 400, 411, 463, 536, 579, 591, 647, 658, 846, 909, 949, 952, 954, 979, 983, 994, 1012, 1015, 1037, 1074, 1095, 1104, 1204, 1316, 1374, 1420, 1542, 1641, 1735, 1769, 1798, 1833, 2050, 2154, 2194, 2203, 2213, 2243, 2268, 2312, 2320, 2337, 2377, 2403, 2506, 2531, 2650, 2709, 2921, 2931, 2944, 3152, 3438, 3464, 3487, 3565, 3570, 3601, 3681, 3699, 3735, 3744, 3762, 3804, 3822, 4085, 4111, 4140, 4229, 4266, 4311, 4355, 4371, 4430, 4437], 'normal': [77, 296, 984], 'fibroblasts.': [78, 297], 'However,': [79, 298, 904, 1738, 3467, 3901], 'full-length': [81, 300, 3516, 3575, 3778, 3794, 3826, 4488, 4495, 4507], 'was': [84, 123, 303, 342, 460, 728, 1010, 1183, 1898, 1904, 1913, 1971, 2018, 2132, 2271, 2346, 2373, 2417, 2433, 2459, 2503, 2536, 2567, 2665, 2748, 2784, 2788, 2822, 2975, 3229, 3277, 3336, 3548, 3625, 3802, 3828, 3986, 4062, 4192, 4274, 4387, 4409, 4423, 4453, 4513], 'largely': [85, 304], 'cytoplasmic,': [86, 305], 'suggesting': [87, 306, 739, 4058], 'its': [89, 308, 493, 774, 847, 3318, 3816], 'may': [92, 311, 1064, 3456, 3582, 3752], 'not': [93, 312, 1304, 1425, 1447, 3235, 3337, 3354, 3556, 4128, 4175, 4262, 4492, 4502], 'be': [94, 205, 313, 424, 743, 860, 1067, 1372, 1649, 3458, 3583, 3697, 3753, 4353], 'able': [95, 314, 744, 786, 3459, 4063, 4424, 4465], 'make': [97, 316], 'intermolecular': [98, 317], 'interactions': [99, 318], 'unstimulated': [101, 320], 'cells.': [102, 321, 1380, 1737, 3863], 'In': [103, 174, 322, 393, 835, 1166, 1404, 1525, 1553, 3254, 3531, 3724, 4115, 4477], 'Src-transformed': [104, 175, 323, 394, 955, 1075, 1167, 1210, 1301, 3602, 3682, 3708, 3737, 3745, 3789, 3862], 'cells,': [105, 176, 324, 395, 2215, 3746, 3990], 'we': [106, 325, 1614, 1804, 1823, 1837, 3110, 3241, 3475, 3705, 3786, 3872, 4091, 4120, 4357, 4480], 'observed': [107, 326, 3639], 'dramatic': [109, 328], 're-localization': [110, 329, 3610], 'some': [112, 331, 695, 3612, 4070, 4252, 4334], 'molecules': [114, 333, 705, 1842], 'actin-rich': [116, 335, 1157], 'called': [118, 337, 1109, 1179, 1387], 'podosomes;': [119, 338, 1310], 'necessary': [125, 344, 3773, 3852], 'sufficient': [127, 346, 3854], 'effect': [129, 348], 'this': [130, 349, 1405, 1560, 3255, 3311, 3717, 3954, 4431], 'translocation.': [131, 350], 'used': [133, 352, 1626, 1824, 2823, 3242], 'phage': [135, 354, 1619, 1653, 1779, 1830, 1984, 2445, 2820, 3969, 3997, 4031, 4142, 4184, 4189, 4208, 4226, 4242, 4271, 4290, 4308, 4324], 'display': [136, 355, 1620, 1623, 1721, 1780, 1831, 3970, 4143, 4146, 4190, 4272], 'screen': [137, 356, 465, 4119, 4191, 4273, 4373], 'fifth': [140, 359, 1851, 2156, 3977], 'isolated': [146, 365, 462, 3452, 3535, 4052, 4093, 4121, 4139], 'ADAM19': [147, 366, 1923, 1947, 1970, 2216, 4105, 4122, 4135, 4351, 4368, 4508, 4512], 'partner.': [151, 370], 'Subsequent': [152, 371], 'analyses': [153, 372], 'mammalian': [155, 374, 4380], 'cells': [156, 375, 956, 985, 1014, 1076, 1100, 1211, 1302, 1307, 1323, 1436, 1982, 2205, 2306, 2400, 2421, 2528, 2763, 2827, 3315, 3405, 3525, 3604, 3683, 3710, 3738, 3790, 3885, 4402], 'demonstrated': [157, 376], 'interacts': [160, 379], 'several': [162, 381, 513, 643, 671, 3200, 3551], 'members': [163, 184, 382, 403, 1555], 'ADAMs': [166, 169, 187, 385, 388, 406, 1460, 1531, 1558, 1579, 1986], 'family,': [167, 386, 1559], 'including': [168, 387, 1232], '12,': [170, 389], '15,': [171, 390], '19.': [173, 392], 'ADAM12': [177, 396, 1945], 'co-localized': [178, 397, 3626], 'podosomes.': [182, 401, 3689, 3723, 3763, 3781], 'Because': [183, 402], 'family': [188, 407, 1443, 1461, 1580], 'been': [190, 409, 675, 1108, 1314, 1625, 3145, 3364, 3638], 'implicated': [191, 410], 'growth': [193, 412, 450, 1020, 1025, 1587, 2242], 'factor': [194, 413, 451], 'processing,': [195, 414], 'cell': [199, 418, 1543, 1599, 1860, 2188, 2197, 2782, 3621, 4385], 'adhesion': [200, 419], 'motility,': [202, 421], 'could': [204, 423, 507, 4352], 'acting': [206, 425], 'adaptor': [209, 428, 2103, 3422], 'molecule': [210, 429, 548, 3779, 4497], 'allows': [212, 431, 1782], 'impinge': [215, 434], 'on': [216, 435, 778, 1159, 1651, 2264, 2830, 2915, 3509, 3915, 4022, 4254, 4336], 'these': [217, 436, 532, 1169, 1186, 1368, 3239, 3566, 3949, 4401], 'processes.': [218, 437], 'phox': [438], 'glutathioneS-transferase': [443], '4)P2,': [446], '3,4-bisphosphate': [448], 'epidermal': [449], 'phosphate-buffered': [454], 'saline': [455], 'tetramethylrhodamine': [456], 'iso-': [457], 'thiocyanate': [458], 'originally': [461], 'identify': [467], 'substrates': [469], '(1Lock': [470, 957, 1041, 1870], 'P.': [471, 958, 1042, 1478, 1871, 3016], 'Abram': [472, 959, 1043, 1674, 1872, 2385, 4005], 'C.L.': [473, 960, 1044, 1873], 'Gibson': [474, 961, 1045, 1874], 'T.': [475, 799, 801, 962, 1046, 1112, 1246, 1350, 1875, 2987, 3052, 3642], 'Courtneidge': [476, 963, 1047, 1465, 1876], 'S.A.': [477, 964, 1048, 1466, 1877], 'EMBO': [478, 965, 1049, 1878, 2122, 3394], 'J.': [479, 866, 966, 1050, 1214, 1285, 1396, 1513, 1516, 1710, 1879, 2123, 3028, 3071, 3078, 3165, 3395], '1998;': [480, 967, 1051, 1288, 1504, 1880], '17:': [481, 968, 1052, 1470, 1681, 1881, 2392, 4012], '4346-4357Crossref': [482, 969, 1053, 1882], 'PubMed': [483, 608, 716, 756, 812, 899, 970, 1054, 1125, 1146, 1220, 1268, 1296, 1338, 1401, 1472, 1491, 1507, 1522, 1683, 1696, 1715, 1883, 2127, 2394, 2886, 3000, 3041, 3065, 3084, 3169, 3189, 3399, 3655, 3676, 4014], 'Scopus': [484, 609, 717, 757, 813, 900, 971, 1055, 1126, 1147, 1221, 1269, 1297, 1339, 1473, 1492, 1508, 1684, 1697, 1716, 1884, 2128, 2395, 2887, 3001, 3042, 3066, 3085, 3170, 3190, 3400, 3656, 3677, 4015], '(153)': [485, 972, 1056, 1885], 'Google': [486, 611, 719, 759, 815, 902, 973, 1057, 1128, 1149, 1223, 1252, 1271, 1299, 1341, 1362, 1402, 1475, 1494, 1510, 1523, 1686, 1699, 1718, 1886, 2130, 2397, 2889, 3003, 3044, 3068, 3087, 3172, 3192, 3402, 3658, 3679, 4017], 'Scholar).': [487, 612, 720, 760, 816, 903, 974, 1058, 1150, 1224, 1300, 1403, 1524, 1719, 1887, 2890, 3193, 3403, 4018], 'has': [489, 842, 926, 1091, 1198, 1624, 3363, 3868], 'PX1domain': [491], 'at': [492, 2359, 2556, 2599, 2676, 2743, 2775, 2842, 4362], 'amino': [494, 562, 573, 1936, 4180], 'terminus': [495], 'polyproline-rich': [504], 'mediate': [508, 1569], 'association': [509], 'possible': [514, 907, 3494], 'phosphorylation': [515, 1003], 'sites': [516], 'serine/threonine': [519], 'tyrosine': [521, 1002], 'kinases,': [522], 'potentially': [524], 'four': [525, 2704], 'alternatively': [526], 'spliced': [527], 'forms.': [528], 'The': [529, 630, 667, 687, 921, 1072, 1441, 1888, 2014, 2091, 2371, 2457, 2473, 2501, 2565, 2603, 2694, 2746, 2786, 3274, 3436, 3545, 3558, 4218, 4233, 4300, 4315, 4383], 'presence': [530], 'domains': [533, 555, 584, 588, 673, 680, 697, 723, 748, 1538, 1611, 2037, 2097, 3092, 3142, 3155, 3357, 3370, 3470, 3486, 4461], 'suggests': [538, 3568], 'it': [540, 727, 905, 1182, 3362, 3492, 3624, 3801, 4377], 'might': [541, 742, 823, 917, 1188, 1370, 3696], 'act': [542], 'scaffold': [545], 'or': [546, 1066, 1175, 1666, 1932, 2034, 2045, 2054, 2913, 3342, 3631, 3759, 4394], 'docking': [547], 'proteins': [551, 596, 644, 656, 1532, 1605, 1665, 2284, 2352, 2364, 3114, 3367, 3877, 3892, 3973, 4054, 4074, 4415], 'lipids.': [553, 686, 3100, 3282], 'are': [556, 576, 1032, 1084, 1178, 1202, 1303, 1418, 1540, 1748, 2262, 3137, 3371, 4079, 4227, 4309], 'independently': [557, 4092], 'folding': [558], 'modules': [559], '∼120': [561], 'acids,': [563], 'overall': [566], 'hydrophobic': [567], 'character': [568], 'but': [569, 694, 1458, 4491], 'few': [570, 1081, 1760, 4179], 'totally': [571], 'conserved': [572, 933, 3138], 'acids.': [574], 'They': [575], 'frequently': [577], 'found': [578, 1103, 3372], 'combination': [580], 'interaction': [583, 1571, 4347], 'such': [585, 1022, 1725], 'exist': [590], 'diverse': [593], 'array': [594, 1816, 3245], 'wide': [598], 'ranging': [599], 'functions': [600], '(2Ponting': [601, 749], 'C.P.': [602, 750, 1515, 2878], 'Protein': [603, 751, 2266, 2685], 'Sci.': [604, 752, 1118, 1518, 3648], '1996;': [605, 753], '5:': [606, 754], '2353-2357Crossref': [607, 755], '(269)': [610, 758], 'For': [613, 2210], 'example,': [614], 'p40phox': [616], 'p47phox': [618, 769, 795], 'subunits': [619], 'NADPH': [622], 'oxidase': [623], 'system': [624, 1766], 'phagocytes': [626], 'contain': [627, 1226, 1309, 1385, 1437], 'domains.': [629], 'enzymes': [631], 'CISK': [632], '(cytokine-independent': [633], 'survivalkinase)': [634], 'phospholipase': [636], 'D': [637, 991], 'do': [642], 'function': [646, 1581, 3151], 'vesicular': [648], 'sorting': [649, 653], '(for': [650], 'example': [651], 'nexins),': [654], 'involved': [657, 1203, 1373, 1419, 1541, 3698], 'cytoskeletal': [659, 1070], 'organization': [660], 'yeast': [663], 'bud': [664], 'emergence': [665], 'proteins).': [666], 'capabilities': [669], 'reported': [676, 941, 1315, 2976], 'recently.': [677], 'All': [678, 2179], 'tested': [681, 3809], 'bind': [682, 699, 746, 788, 833, 2099, 3097, 3280, 3359, 4426], 'phosphorylated': [684, 3098], 'most': [688, 3262], 'common': [689], 'partner': [691], 'PtdIns3P,': [693, 3360], 'will': [698, 3938], 'PtdIns(3,4)P2': [700], 'other': [702, 910, 1742, 3153, 3232, 3272, 3504, 4459], 'substituted': [703], '(3Sato': [706], 'T.K.': [707, 3049], 'Overduin': [708, 3057], 'M.': [709, 1257, 1278, 1327, 1671, 1691, 2111, 2382, 2872, 3058, 3383, 4002], 'Emr': [710, 3055], 'S.D.': [711, 3056], 'Science.': [712, 1917], '2001;': [713, 809, 891, 2997, 3038, 3062, 3081, 3166, 3181], '294:': [714], '1881-1885Crossref': [715], '(207)': [718], 'When': [721], 'were': [724, 1891, 1924, 1948, 1990, 2038, 2072, 2150, 2167, 2181, 2191, 2219, 2253, 2278, 2285, 2307, 2365, 2401, 2696, 2732, 2846, 2851, 2863, 2898, 2904, 2919, 2952, 2967, 3471, 3476, 4038, 4042, 4209, 4214, 4291, 4296, 4403, 4416, 4464], 'first': [725, 3294, 3706, 3787, 4113, 4231, 4313], 'identified,': [726], 'also': [729, 841, 977, 1313, 1371, 1384, 1459, 3358, 3457, 3501, 4485], 'noted': [730, 3325], 'many': [732, 1554, 3090, 4157, 4238, 4320], 'them': [734], 'contained': [735, 2475, 4244, 4326], 'PXXP': [737, 775, 844, 929, 1565, 4056, 4158, 4162, 4168, 4172], 'motif,': [738], 'they': [741, 1311], 'Indeed,': [761, 3404], 'structural': [762], 'analysis': [763, 2495, 3256, 3521, 3955, 4223, 4305], 'by': [770, 1926, 1973, 2040, 2074, 2183, 2367, 2461, 2493, 2569, 2698, 2706, 2790, 2853, 2867, 3321, 3519, 3956, 4046, 4418, 4445, 4515], 'NMR': [771], 'showed': [772, 3426, 3539, 3837, 3922, 4481], 'motif': [776, 845, 930], 'surface': [780, 1162, 4442], 'second': [791, 4234, 4316], '(4Hiroaki': [796], 'H.': [797, 803, 1240, 1242, 1244, 1274, 2121, 2981, 2985, 3014, 3393], 'Ago': [798], 'Ito': [800], 'Sumimoto': [802], 'Kohda': [804], 'D.': [805, 868, 1133, 1259, 1329, 3073, 3663], 'Nat.': [806, 1678, 2389, 2994, 3035, 3059, 4009], 'Struct.': [807], 'Biol.': [808, 1286, 1503, 2996, 3037, 3061, 3080], '8:': [810, 892], '526-530Crossref': [811], '(152)': [814], 'These': [817, 1059, 3135, 3629, 3740], 'data': [818, 1060, 3741], 'suggested': [819, 1199], 'impact': [824], 'ability': [826, 3095], 'simultaneously': [831], 'PtdIns3P.': [834], 'related': [837], 'p40phox,': [839], 'which': [840, 1414, 1454, 4408, 4438], 'domain,': [849, 1530, 3537], 'lipid': [850, 912, 1818, 1826, 3149, 3589, 3758], 'appears': [858], 'neither': [861], 'cooperative': [862], 'nor': [863], 'antagonistic': [864], '(5Bravo': [865], 'Karathanassis': [867], 'Pacold': [869, 871], 'C.M.': [870], 'M.E.': [872], 'Ellson': [873], 'C.D.': [874, 3006], 'Anderson': [875, 3009], 'K.E.': [876, 3010], 'Butler': [877], 'P.J.': [878], 'Lavenir': [879], 'I.': [880], 'Perisic': [881], 'O.': [882], 'Hawkins': [883, 3031], 'P.T.': [884, 3032], 'Stephens': [885, 3033], 'L.': [886], 'Williams': [887], 'R.L.': [888], 'Mol.': [889], 'Cell.': [890, 3180], '829-839Abstract': [893], 'Full': [894, 896, 1291, 1293, 1486, 1488, 3184, 3186, 3926], 'Text': [895, 897, 1292, 1294, 1487, 1489, 3185, 3187], 'PDF': [898, 1295, 1490, 3188], '(241)': [901], 'remains': [906, 3493], 'proteins,': [911, 1231], 'influence': [918], 'each': [919, 3906, 3935, 3947, 4225, 4307], 'other.': [920], 'residues': [934, 3136], 'required': [935], 'phospholipid': [937], 'binding.': [938], 'recently': [940, 2977], 'substrate': [947], 'vitro': [950], 'vivo': [953], 'tyrosine-phosphorylated': [978], 'Src-dependent': [981], 'manner': [982], 'treated': [986], 'concentrations': [988, 3251], 'cytochalasin': [990], 'result': [993, 3547], 'rearrangement': [995], 'cortical': [998], 'actin': [999, 1039, 1082, 1409, 3635], 'cytoskeleton.': [1000], 'Furthermore,': [1001, 1762, 4455], 'Fish,': [1005, 1613, 3704, 4511], 'albeit': [1006], 'slow': [1008], 'kinetics,': [1009], 'detected': [1011, 3270, 4354], 'Rat1': [1013], 'response': [1016], 'treatment': [1018], 'factors': [1021, 1588], 'platelet-derived': [1024], 'factor,': [1026], 'lysophosphatidic': [1027], 'acid,': [1028], 'bradykinin': [1030], 'known': [1033], 'promote': [1035], 'changes': [1036], 'cytoskeleton': [1040, 1073], 'suggest': [1061, 3449, 3742], 'impact,': [1065], 'impacted': [1068], 'by,': [1069], 'regulation.': [1071], 'grossly': [1078], 'abnormal.': [1079], 'Very': [1080], 'filaments': [1083], 'detected.': [1085], 'Instead,': [1086], 'much': [1087], 'F-actin': [1090], 'ring-like': [1093], 'appearance': [1094], 'cortex': [1097], 'podosomes': [1110, 1170, 1201, 1388, 1430, 3805, 3833, 3860], '(6David-Pfeuty': [1111, 3641], 'Singer': [1113, 3643], 'S.J.': [1114, 2983, 3644], 'Proc.': [1115, 3645], 'Natl.': [1116, 3646], 'Acad.': [1117, 3647], 'U.': [1119, 3649], 'S.': [1120, 1669, 2380, 3008, 3650, 4000], 'A.': [1121, 1348, 1390, 2874, 3651], '1980;': [1122, 3652], '77:': [1123, 3653], '6687-6691Crossref': [1124, 3654], '(224)': [1127, 3657], 'Scholar,': [1129, 1253, 1272, 1342, 1476, 1495, 1511, 1687, 1700, 3004, 3045, 3069, 3173, 3659], '7Tarone': [1130, 3660], 'G.': [1131, 1706, 3075, 3661], 'Cirillo': [1132, 3662], 'Giancotti': [1134, 3664], 'F.G.': [1135, 3665], 'Comoglio': [1136, 3666], 'P.M.': [1137, 3667], 'Marchisio': [1138, 1391, 3668], 'P.C.': [1139, 1392, 3669], 'Exp.': [1140, 1215, 3670], 'Cell': [1141, 1502, 1517, 2995, 3036, 3060, 3079, 3671], 'Res.': [1142, 1248, 1358, 3672], '1985;': [1143, 3673], '159:': [1144, 3674], '141-157Crossref': [1145, 3675], '(348)': [1148, 3678], 'Each': [1151, 3887], 'podosome': [1152], 'fine,': [1155], 'cylindrical,': [1156], 'structure': [1158], 'ventral': [1161], 'cell.': [1165, 3490], 'fibroblasts,': [1168], 'cluster': [1171], 'form': [1173], 'rings': [1174, 3630], 'semi-circles': [1176, 3632], 'rosettes.': [1180], 'Although': [1181], 'thought': [1184], 'simply': [1189], 'represent': [1190], 'remnants': [1191], 'focal': [1193], 'adhesions,': [1194], 'more': [1195, 2692, 3541], 'recent': [1196], 'research': [1197], 'driving': [1205], 'locomotion': [1206], 'invasion': [1208], '(8Chen': [1212], 'W.T.': [1213, 1284, 1356], 'Zool.': [1216], '1989;': [1217], '251:': [1218], '167-185Crossref': [1219], '(281)': [1222], 'Podosomes': [1225], 'number': [1228, 2025, 3910], 'cytoskeleton-associated': [1230], 'N-WASP,': [1233], 'cortactin,': [1234], 'paxillin,': [1235], 'p190RhoGAP(9Mizutani': [1237], 'K.': [1238, 1708, 3012], 'Miki': [1239], 'He': [1241], 'Maruta': [1243], 'Takenawa': [1245], 'Cancer': [1247, 1357], '2002;': [1249], '62:': [1250], '669-674PubMed': [1251], '10Bowden': [1254], 'E.T.': [1255, 1325], 'Barth': [1256, 1326], 'Thomas': [1258, 1328], 'Glazer': [1260, 1330], 'R.I.': [1261, 1331], 'Mueller': [1262, 1275, 1332, 1353], 'S.C.': [1263, 1276, 1333, 1354], 'Oncogene.': [1264, 1334], '1999;': [1265, 1335, 1519, 1680, 2391, 2883, 4011], '18:': [1266, 1336], '4440-4449Crossref': [1267, 1337], '(311)': [1270, 1340], '11Nakahara': [1273], 'Nomizu': [1277], 'Yamada': [1279], 'Y.': [1280, 1282, 3157], 'Yeh': [1281], 'Chen': [1283, 1355], 'Chem.': [1287], '273:': [1289], '9-12Abstract': [1290], '(155)': [1298], 'only': [1306, 1786, 3836], 'invasive': [1317], 'human': [1318, 1378], 'breast': [1319], 'cancer': [1320], 'melanoma': [1322], '(10Bowden': [1324], '12Monsky': [1343], 'W.L.': [1344], 'Lin': [1345], 'C.Y.': [1346], 'Aoyama': [1347], 'Kelly': [1349], 'Akiyama': [1351], 'S.K.': [1352], '1994;': [1359, 1712], '54:': [1360], '5702-5710PubMed': [1361], 'Scholar),': [1363], 'raising': [1364], 'possibility': [1366], 'metastatic': [1375], 'properties': [1376], 'tumor': [1379], 'Osteoclasts': [1381], 'macrophages': [1383], '(13Teti': [1389], 'Zallone': [1393], 'A.Z.': [1394], 'Am.': [1395], 'Physiol.': [1397], '1991;': [1398], '261:': [1399], 'C1-C7Crossref': [1400], 'case,': [1406], 'one': [1407, 1739, 4161, 4167], 'large': [1408, 1773], 'ring': [1410], 'formed,': [1412], 'from': [1413, 1591, 1893, 1899, 1905, 1914, 1980, 2020, 2419, 2750, 2900, 3616, 3893, 3988, 4400], 'protrusions': [1415], 'emerge': [1416], 'bone': [1421], 'remodeling.': [1422], 'yet': [1426], 'clear': [1427], 'whether': [1428, 3103, 3692, 3766, 3866, 4345, 4506], 'osteoclasts': [1432], 'transformed': [1435], 'same': [1439, 3489, 3546], 'components.': [1440], 'metzincin': [1442], 'metalloproteases': [1445, 1451], 'just': [1448, 1758], 'matrix': [1450, 1601], '(some': [1452], 'co-localize': [1455], 'podosomes)': [1457], 'proteases': [1462], '(14Seals': [1463], 'D.F.': [1464], 'Genes': [1467], 'Dev.': [1468], '2003;': [1469], '7-30Crossref': [1471], '(904)': [1474], '15Primakoff': [1477], 'Myles': [1479], 'D.G.': [1480], 'Trends': [1481], 'Genet.': [1482], '2000;': [1483, 2124, 3396], '16:': [1484], '83-87Abstract': [1485], '(518)': [1493], '16Black': [1496], 'R.A.': [1497, 2876], 'White': [1498], 'J.M.': [1499, 2117, 3389], 'Curr.': [1500], 'Opin.': [1501], '10:': [1505], '654-659Crossref': [1506], '(431)': [1509], '17Schlondorff': [1512], 'Blobel': [1514], '112:': [1520], '3603-3617Crossref': [1521], 'addition': [1526], 'metalloprotease': [1529], 'disintegrin,': [1534], 'cysteine-rich,': [1535], 'EGF-like': [1537], 'adhesion,': [1544], 'membrane': [1546], 'spanning': [1547], 'sequence,': [1548, 4246, 4328], 'cytoplasmic': [1551, 1561, 3543, 3840, 4102, 4155], 'tail.': [1552], 'tail': [1562, 4103], 'can': [1568, 3500], 'Members': [1576], 'sheddases': [1583], '(by': [1584], 'cleaving': [1585], 'active': [1586], 'cytokines': [1590], 'their': [1592], 'inactive': [1593], 'precursors),': [1594], 'mediating': [1598], 'interactions.': [1602], 'To': [1603, 1792, 2511, 3101, 3237, 3690, 3864, 4343, 4504], 'isolate': [1604, 3972], 'bound': [1607, 2353, 3108, 3218, 3261, 3890, 4410, 4414, 4509], 'chose': [1615, 3966], 'use': [1617, 3968], 'screen.': [1621, 4114], 'Phage': [1622, 1720, 4040], 'extensively': [1627], 'generation': [1630], 'monoclonal': [1632], 'antibodies': [1633, 1868, 1890, 1943, 3528, 3554], 'screening': [1636, 1659, 1756, 1781], 'peptide': [1637], 'libraries.': [1638], 'Recent': [1639], 'advances': [1640], 'technology': [1642], 'allowed': [1644], 'larger': [1645], 'insert': [1646, 2484], 'sequences': [1647, 4259, 4341], 'expressed': [1650, 2049, 4053], 'surface,': [1654], 'thus': [1655], 'facilitating': [1656], 'rapid': [1658], 'cDNA': [1661, 1977, 2432, 2458, 2514, 3984], 'libraries': [1662], 'against': [1663], 'target': [1664, 1733, 3761, 3856], 'peptides': [1667], '(18Zozulya': [1668, 3999], 'Lioubin': [1670, 2381, 4001], 'Hill': [1672, 2383, 4003], 'R.J.': [1673, 2384, 4004], 'C.': [1675, 2386, 4006], 'Gishizky': [1676, 2387, 4007], 'M.L.': [1677, 2388, 3047, 4008], 'Biotechnol.': [1679, 2390, 4010], '1193-1198Crossref': [1682, 2393, 4013], '(73)': [1685, 2396, 4016], '19Crameri': [1688], 'R.': [1689, 1702, 1704, 2113, 3385], 'Suter': [1690], 'Gene.': [1692], '1993;': [1693], '137:': [1694], '69-75Crossref': [1695], '(177)': [1698], '20Crameri': [1701], 'Jaussi': [1703], 'Menz': [1705], 'Blaser': [1707], 'Eur.': [1709], 'Biochem.': [1711, 3164], '226:': [1713], '53-58Crossref': [1714], '(148)': [1717], 'does': [1722], 'limitations,': [1724], 'issues': [1727], 'production': [1730], 'bacterial': [1736, 2269], 'advantage': [1740], 'over': [1741, 4405], 'methods': [1743], 'once': [1746, 2505], 'reagents': [1747], 'generated,': [1749], 'process': [1751], 'very': [1753], 'rapid,': [1754], 'taking': [1757], 'days.': [1761], 'although': [1763], 'two-hybrid': [1765], 'often': [1767], 'results': [1768, 4219, 4301], 'detection': [1771, 3561], 'numbers': [1774], 'low': [1776], 'affinity': [1777, 1789], 'interactors,': [1778], 'identification': [1784, 1840, 2024, 3941], 'highest': [1788], 'interacting': [1790, 3755], 'molecules.': [1791], 'determine': [1793, 3691, 3865, 4344], 'role': [1795], 'signaling': [1799], 'pathways': [1800], 'downstream': [1801], 'Src,': [1803], 'begun': [1806], 'look': [1808], 'partners': [1811, 3913, 3962], 'Fish.': [1813, 1855, 3292, 3307, 3981], 'Given': [1814], "Fish's": [1815], 'assays': [1828, 2862], 'screens': [1832], 'our': [1834, 1859, 4112], 'analyses.': [1835], 'Here': [1836], 'describe': [1838], 'interact': [1844, 4467], 'described': [1858, 2376, 2663, 2866, 4195, 4277], 'lines,': [1861], 'Fish-': [1865], 'Src-specific': [1867], 'before': [1869, 2509, 3640], 'following': [1889], 'purchased': [1892], 'commercial': [1894], 'sources;': [1895], 'anti-phosphotyrosine': [1896], '(4G10)': [1897], 'Upstate': [1900], 'Biotechnology,': [1901, 1908], 'anti-Myc': [1902], '(9E10)': [1903], 'Santa': [1906], 'Cruz': [1907], 'Inc.,': [1909], 'anti-hemagglutinin': [1911], '(12CA5)': [1912], 'Roche': [1915], 'Applied': [1916], 'Antibodies': [1918], 'specific': [1919], 'GST': [1921, 1931, 1933, 2350, 2673, 3112, 3899], 'generated': [1925, 2039, 2168, 3295], 'immunizing': [1927], 'rabbits': [1928], 'purified': [1930, 2418], 'fused': [1934, 3301, 3472, 4182], 'acids': [1937, 2070, 4181], '728–807': [1938], 'ADAM19,': [1940], 'respectively.': [1941], 'Additional': [1942], 'recognizing': [1944], 'kind': [1950, 1992, 2134], 'gifts': [1951, 1993], 'Drs.': [1953, 1995], 'Ulla': [1954, 2007], 'Wewer': [1955, 2008], '(University': [1956, 1998, 2009], 'Copenhagen,': [1958, 1959, 2011, 2012], 'Denmark)': [1960], 'Anna': [1962], 'Zolkiewska': [1963], '(Kansas': [1964], 'State': [1965], 'University,': [1966], 'Manhattan,': [1967], 'Kansas).': [1968], 'Full-length': [1969], 'cloned': [1972, 2440, 3993, 4215, 4297, 4514], 'PCR': [1974, 2494, 2854], 'using': [1975, 2169, 2199, 2206, 2227, 2287, 2422, 2446, 2954, 2961, 3206, 3526], 'library': [1978, 2474, 2502, 2515, 2551, 3985], 'prepared': [1979, 2661, 3111, 3195, 3208], 'NIH3T3': [1981, 2204, 2214, 2305, 2399, 3314, 3524, 3603, 3709, 3884, 3989], 'display.': [1985], '9': [1987], '12': [1989], 'Deepa': [1996], 'Nath': [1997], 'East': [2000, 2002], 'Anglia,': [2001, 2003], 'United': [2004], 'Kingdom)': [2005], 'Denmark).': [2013], 'fragment': [2015, 2080, 4369], 'ADAM15': [2017], 'obtained': [2019, 2899, 3549, 4370], 'ATCC': [2022], '(clone': [2023], '592208).': [2026], 'Fragments': [2027], 'containing': [2030, 2094, 2327, 3368, 4396, 4498], 'individual': [2035, 2349], 'PCR,': [2041], 'subcloned': [2042, 2220, 4043, 4376], 'into': [2043, 2087, 2221, 2441, 3313, 3994, 4378], 'pGEX-2T': [2044], 'pGEX-4T': [2046], 'vectors,': [2047], 'Escherichia': [2051], 'coli': [2052, 2526, 2588, 2761], 'DH5': [2053], 'BL21.': [2055], 'Fusions': [2056], '(GFP)': [2062], '(amino': [2069], '1–121)': [2071], 'constructed': [2073], 'subcloning': [2075], 'PCR-generated': [2077], '(XhoI-KpnI': [2081], 'ends;': [2082], 'Kozak': [2085], 'sequence)': [2086], 'pEGFP-N1': [2088], '(BD': [2089], 'Biosciences).': [2090], 'GFP': [2092, 3300, 3340, 3348, 3412], 'two': [2095, 3414], 'FYVE': [2096, 3356, 3369, 3418, 3485], '(which': [2098], 'PtdIns3P)': [2100], 'Hrs': [2105, 3424], '(21Gillooly': [2106, 3378], 'D.J.': [2107, 3379], 'Morrow': [2108, 3380], 'I.C.': [2109, 3381], 'Lindsay': [2110, 3382], 'Gould': [2112, 3384], 'Bryant': [2114, 3386], 'N.J.': [2115, 3387], 'Gaullier': [2116, 3388], 'Parton': [2118, 3390], 'R.G.': [2119, 3391], 'Stenmark': [2120, 3392], '19:': [2125, 3397], '4577-4588Crossref': [2126, 3398], '(877)': [2129, 3401], 'Scholar)': [2131, 3088, 3680], 'gift': [2135], 'Dr.': [2137], 'Ed': [2138], 'Skolnik': [2139], '(The': [2140], 'Skirball': [2141], 'Institute,': [2142], 'New': [2143], 'York,': [2144], 'NY).': [2145], 'Standard': [2146], 'molecular': [2147, 3944], 'biology': [2148], 'techniques': [2149], 'used.': [2151], 'Point': [2152], 'mutations': [2153], '(W1056A)': [2159], '(R42A,R93A)': [2164], 'Stratagene': [2171], 'Quik': [2172], 'Change': [2173], 'kit': [2174, 2428, 2450], 'according': [2175, 2235, 2256, 2300, 2452], "manufacturer's": [2177, 2237, 2303, 2455], 'instructions.': [2178, 2304, 2456], 'constructs': [2180], 'confirmed': [2182], 'DNA': [2184, 2635], 'sequence': [2185, 4222, 4304], 'analysis.': [2186, 3323], 'Mammalian': [2187], 'transient': [2189], 'transfections': [2190], 'carried': [2192, 2254], 'out': [2193, 2255], '293': [2196, 4384], 'line': [2198, 4386], 'LipofectAMINE': [2200, 2207], '(Invitrogen)': [2201], '2000': [2208], '(Invitrogen).': [2209, 2414, 2429], 'stable': [2211], 'expression': [2212, 2267, 4381], 'ADAM19-ΔMP': [2218], 'pBABEpuro3': [2223], 'retroviral': [2224], 'vector,': [2225], 'transfected': [2226, 3310, 3406, 3707, 3788, 4389], 'calcium': [2228], 'phosphate': [2229], '(CellPhect': [2230], 'Transfection': [2231], 'kit;': [2232], 'Amersham': [2233], 'Biosciences)': [2234, 2299], 'instructions,': [2238], 'selected': [2240, 3891], 'puromycin': [2244], '(6': [2245], 'ॖg/ml).': [2246], 'Immunoprecipitation': [2247], 'analyses,': [2248], 'gel': [2249, 2463], 'electrophoresis,': [2250], 'immunoblotting': [2252, 4419], 'standard': [2258], 'procedures.': [2259], 'Detailed': [2260], 'protocols': [2261], 'available': [2263], 'request.': [2265], 'cultures': [2270], 'induced': [2272], '0.2': [2274], 'mm': [2275, 2620, 2642, 2647], 'isopropyl-1-thio-औ-d-galactopyranoside,': [2276], 'bacteria': [2277], 'lysed,': [2279], 'then': [2281, 2335, 2554, 2581, 3808], 'affinity-purified': [2286], 'glutathione-Sepharose,': [2288], 'eluted,': [2289], 'and,': [2290, 3221], 'where': [2291, 3623], 'required,': [2292], 'coupled': [2293], 'cyanogen': [2295], 'bromide-activated': [2296], 'Sepharose': [2297], '(Amersham': [2298], 'grown': [2308, 2402, 2530, 2555, 2905], '507': [2310], 'confluence': [2311], '10-cm': [2313], 'dishes': [2314], 'incubated': [2316, 2347, 2666, 2774, 3873], '4.5': [2318], 'h': [2319, 2358, 2839, 2911], 'methionine-and': [2321], 'cysteine-free': [2322], "Dulbecco's": [2323, 2404, 2651], 'modified': [2324, 2405], "Eagle's": [2325, 2406], 'medium': [2326, 2407], '0.5': [2328], 'mCi': [2329], '[35S]methionine': [2331], '[35S]cysteine': [2333], 'lysed': [2336], 'Nonidet': [2338, 2609], 'P-40': [2339, 2610], 'lysis': [2340, 2783], 'buffer.': [2341], '150': [2342], 'ॖg': [2343], 'lysate': [2345, 2566, 2660, 2787], 'glutathione-Sepharose': [2355, 4023, 4406], '4': [2357, 2360, 2677], '°C.': [2361, 2844], 'Fusion': [2362, 2684], 'protein-associated': [2363], 'analyzed': [2366, 2953, 4045, 4417], 'SDS-PAGE': [2368], 'fluorography.': [2370], 'methodology': [2372], 'essentially': [2374], 'Ref.': [2378], '18Zozulya': [2379], 'Scholar.': [2398], 'supplemented': [2408, 2582, 2717], '107': [2410, 2478, 2612], 'fetal': [2411], 'calf': [2412], 'serum': [2413, 2947], 'poly(A)+': [2415], 'RNA': [2416], 'FastTrack': [2424], '2.0': [2425], 'mRNA': [2426], 'purification': [2427], 'Randomly': [2430], 'primed': [2431], 'synthesized,': [2434], 'ligated': [2435], 'adapters,': [2437], 'uni-directionally': [2439], 'EcoRI-HindIII-cut': [2443], 'T7Select1–1b': [2444], 'T7Select1–1': [2448], 'cloning': [2449], '(Novagen)': [2451, 2529, 2598], 'size-selected': [2460], 'agarose': [2462], 'electrophoresis': [2464], 'exclude': [2466], 'fragments': [2467], 'less': [2469, 3222, 3268], 'than': [2470], '500': [2471], 'bp.': [2472], '1': [2476, 2656, 2754], '×': [2477, 2795], 'primary': [2479], 'recombinants': [2480], 'average': [2483], 'length': [2485], '0.7': [2487], '0.8': [2489], 'kb,': [2490], '24': [2497, 4036, 4207, 4241, 4289, 4323], 'randomly': [2498], 'picked': [2499], 'plaques.': [2500], 'amplified': [2504, 2852], 'liquid': [2507], 'culture': [2508, 2523, 2758], 'use.': [2510], 'prepare': [2512], 'panning,': [2517, 4206, 4288], '15': [2518, 2668, 2741], 'ml': [2519, 2540, 2657, 2711, 2755, 2767], 'overnight': [2522, 2757], 'E.': [2525, 2587, 2760], 'BL5615': [2527, 2762], 'Terrific': [2532, 2542, 2769], 'Broth-ampicillin': [2533, 2543, 2770], '(100': [2534, 2771, 2832], 'ॖg/ml)': [2535, 2833], 'diluted': [2537, 2764, 2819], '45': [2539], 'infected': [2545], '∼1010': [2547], 'plaque-forming': [2548], 'unit': [2549], 'stock': [2552], '37': [2557, 2776, 2843, 2922], '°C': [2558, 2678, 2777], 'good': [2560], 'aeration': [2561], 'until': [2562, 2781], 'complete': [2563, 2707], 'lysis.': [2564], 'cleared': [2568], 'centrifugation': [2570, 2699, 2791], '(15': [2571], 'min,': [2572, 2793, 2929, 2937], '18,000': [2573], '×g),': [2574], 'filtered': [2575], 'through': [2576], '0.45': [2578], 'ॖm': [2579], 'filter,': [2580], '17': [2584, 2738], '(v/v)': [2585, 2601], 'protease': [2589], 'inhibitors': [2590], 'mixture': [2591], '(P-8465;': [2592], 'Sigma-Aldrich)': [2593], '10×': [2595, 2604, 2801], 'Pan': [2596, 2605, 2802], 'Mix': [2597, 2606], '9:1': [2600], 'ratio.': [2602], '57': [2608, 2945], '(Fluka),': [2611], 'nonfat': [2613], 'dry': [2614], 'milk': [2615], '(Carnation': [2616], 'brand;': [2617], 'Nestle),': [2618], '10': [2619, 2641, 2928, 2936], 'EGTA,': [2621], '250': [2622, 2628, 2646], 'ॖg/ml': [2623, 2629, 2724], 'heparin': [2625], '(H-2149;': [2626], 'Sigma),': [2627, 2637], 'boiled,': [2631], 'sheared': [2632], 'salmon': [2633], 'sperm': [2634], '(D8661;': [2636], '0.057': [2638], 'sodium': [2639, 2643, 2648], 'azide,': [2640], 'vanadate,': [2644], 'fluoride': [2649], 'PBS': [2652, 2713], '(14190–144;': [2653], 'Invitrogen)': [2654], 'base.': [2655], 'above': [2664, 2690], 'ॖl': [2669, 2736], 'Sepharose-coupled': [2672], '30': [2680], 'min': [2681, 2742], '(see': [2682], '“GST': [2683], 'Production,': [2686], 'Purification,': [2687], 'Use”': [2689], 'details).': [2693], 'beads': [2695, 2731, 4024], 'collected': [2697], 'washed': [2701], 'three': [2702, 4027, 4203, 4285], 'times': [2705, 4110, 4126, 4151], 'resuspension': [2708], '1.5': [2710], 'wash': [2714], 'buffer': [2715], '(PBS': [2716], '0.57': [2719], 'Triton': [2720, 2933], 'X-100': [2721], '25': [2723], 'heparin).': [2725], 'After': [2726, 2811], 'final': [2728, 2815], 'wash,': [2729], 'eluted': [2733], '100': [2735], 'SDS': [2739], 'room': [2744], 'temperature.': [2745], 'eluate': [2747, 2821], 'separated': [2749], 'beads,': [2751], 'added': [2752], 'ॖg/ml),': [2772], 'vigorous': [2779], 'shaking': [2780], 'complete.': [2785], 'clarified': [2789], '(10': [2792], '10,000': [2794], 'g)': [2796], 'filtration,': [2798], 'supplied': [2799], 'Mix,': [2803], 'subjected': [2805], 'next': [2808, 3284, 3594], 'panning': [2809, 2816], 'round.': [2810], 'third': [2813, 4249, 4331], 'round,': [2817], 'serially': [2818], 'infect': [2825], 'BL5403': [2826], 'plated': [2829], 'LB-ampicillin': [2831], 'plates.': [2834], 'Plaques': [2835, 2845], 'appeared': [2836], 'after': [2837], '3–4': [2838], 'incubation': [2841], 'picked,': [2847, 4210, 4292], 'inserts': [2850, 4041, 4213, 4295], 'T7-specific': [2856], 'primers': [2857], 'sequenced.': [2859, 4217, 4299], 'Protein-lipid': [2860], 'overlay': [2861], 'performed': [2864], 'Deak': [2868], 'et': [2869], 'al.': [2870], '(22Deak': [2871], 'Casamayor': [2873], 'Currie': [2875], 'Downes': [2877], 'Alessi': [2879], 'D.R.': [2880], 'FEBS': [2881], 'Lett.': [2882], '451:': [2884], '220-226Crossref': [2885], '(112)': [2888], 'Individual': [2891], 'lipids,': [2892, 3109, 3202], 'PIP': [2893, 2896, 3209, 3244], 'strips,': [2894, 3210], 'arrays': [2897], 'Echelon': [2901], 'Biosciences.': [2902], 'Cells': [2903, 2918], 'minimum': [2908], '48': [2910], 'post-passage': [2912], 'post-transfection': [2914], 'glass': [2916], 'coverslips.': [2917], 'fixed': [2920, 3523], 'formaldehyde': [2923], '(Electron': [2924], 'Microscopy': [2925], 'Sciences)/PBS': [2926], 'permeabilized': [2930], '0.17': [2932], 'X-100/PBS': [2934], 'processed': [2939], 'various': [2941], 'antibody': [2942], 'applications': [2943], 'donkey': [2946], '(Jackson': [2948], 'ImmunoResearch': [2949], 'Laboratories)/PBS.': [2950], 'Slides': [2951], 'Axioplan': [2956], '2': [2957], 'microscope': [2959], '(Zeiss)': [2960], 'appropriate': [2963, 3996], 'filters,': [2964], 'images': [2966], 'captured': [2968], 'Axiovision': [2970], '3.0': [2971], 'software': [2972], '(Zeiss).': [2973], '(23Kanai': [2978], 'F.': [2979], 'Liu': [2980, 3072], 'Field': [2982], 'Akbary': [2984], 'Matsuo': [2986], 'Brown': [2988], 'G.E.': [2989], 'Cantley': [2990], 'L.C.': [2991], 'Yaffe': [2992], 'M.B.': [2993], '3:': [2998, 3039, 3063], '675-678Crossref': [2999], '(511)': [3002], '24Ellson': [3005], 'Gobert-Gosse': [3007], 'Davidson': [3011], 'Erdjument-Bromage': [3013], 'Tempst': [3015], 'Thuring': [3017], 'J.W.': [3018], 'Cooper': [3019], 'M.A.': [3020], 'Lim': [3021], 'Z.Y.': [3022], 'Holmes': [3023], 'A.B.': [3024], 'Gaffney': [3025], 'P.R.': [3026], 'Coadwell': [3027], 'Chilvers': [3029], 'E.R.': [3030], 'L.R.': [3034], '679-682Crossref': [3040], '(364)': [3043], '25Cheever': [3046], 'Sato': [3048], 'de': [3050], 'Beer': [3051], 'Kutateladze': [3053], 'T.G.': [3054], '613-618Crossref': [3064], '(318)': [3067], '26Xu': [3070], 'Gill': [3074], 'Songyang': [3076], 'Z.': [3077], '154:': [3082], '699-705Crossref': [3083], '(97)': [3086], 'test': [3102, 4505], 'wild-type': [3117], 'mutant': [3123, 3276, 3352], '(PXdA)': [3126], 'arginines': [3128], '42': [3129], '93': [3131], 'mutated': [3132], 'alanines.': [3134], 'between': [3139, 4348], 'different': [3140, 3201, 3250, 3552], 'shown': [3146, 3365, 4228, 4310], 'disrupt': [3148], '(27Xu': [3156], 'Seet': [3158], 'L.F.': [3159], 'Hanson': [3160], 'B.': [3161], 'Hong': [3162], 'W.': [3163], '360:': [3167], '513-530Crossref': [3168], '(123)': [3171], '28Wishart': [3174], 'M.J.': [3175], 'Taylor': [3176], 'G.S.': [3177], 'Dixon': [3178], 'J.E.': [3179], '105:': [3182], '817-820Abstract': [3183], '(132)': [3191], 'nitrocellulose': [3196], 'membranes': [3197, 3377], 'spotted': [3198, 3246], 'commercially': [3207], 'show': [3212], 'PtdIns3P': [3220, 3265, 3463], 'strongly,': [3223], 'PtdIns(3,4)P2.': [3225], 'Much': [3226], 'weaker': [3227], 'seen': [3230, 3338, 3441], 'phospholipids': [3233], '(data': [3234, 3353, 3555, 4127, 4501], 'shown).': [3236, 3355, 3557, 4129, 4503], 'confirm': [3238], 'findings,': [3240], 'phosphoinositides': [3248], '(Fig.': [3252, 3434, 3529, 3713, 3842, 4420], '1).': [3253], 'strongly': [3263], 'PtdIns(3,4)P2with': [3267], 'phosphoinositides.': [3273], 'PXdA': [3275, 3351], 'unable': [3278, 3477, 3584, 3829], 'began': [3285, 3953], 'explore': [3287], 'subcellular': [3289, 3319, 3505, 3597], 'localization': [3290, 3320, 3448, 3513, 3598, 3702, 3775], 'consisting': [3298], 'transiently': [3309, 4388], 'construct': [3312, 3718], 'fluorescence': [3322], 'distribution': [3328, 3429], '(Fig.2A).': [3332], 'This': [3333, 3820], 'staining': [3335, 3440, 3564, 3636, 3734, 3841], 'alone': [3341], 'associated': [3373, 4486], 'early': [3375, 3432, 3732], 'endosomal': [3376, 3465, 3733], 'copies': [3415], '(GFP-FYVE)': [3425], 'typical': [3430, 3730], '2B).': [3435], 'similarities': [3437], 'GFP-PX': [3444, 3712], 'GFP-FYVE': [3446, 3727], 'associate': [3461, 3502, 3586, 4082], 'membranes.': [3466], 'because': [3468], 'GFP,': [3474], 'compare': [3479], 'localizations': [3481], 'Thus': [3491, 3844], 'structures.': [3506], 'went': [3508], 'examine': [3511], 'immunofluorescence': [3520], 'Fish-specific': [3527], '2C).': [3530], 'contrast': [3532, 3823], 'generalized': [3542], 'distribution.': [3544], 'lack': [3559], 'experiments': [3567], 'that,': [3569, 3743], 'context': [3572], 'protein,': [3576, 3821], 'intermolecularly': [3587], 'and/or': [3590], 'targets.': [3592], 'examined': [3595], '(Fig.3A).': [3605], 'noticed': [3607], 'striking': [3609], 'fraction': [3613], 'cytoplasm': [3618], 'periphery,': [3622], 'F-actin.': [3628], 'intense': [3634], 'correspond': [3685], 'rosettes': [3687], 'podosomal': [3701], '3B).': [3714], 'Some': [3715], 'did': [3719], 'indeed': [3720], 'localize': [3721, 3831], 'contrast,': [3725], 'gave': [3729], '(Fig.2C).': [3739], 'preferentially': [3754], 'asked': [3765], 'As': [3782], 'positive': [3784], 'control,': [3785], 'tagged,': [3793], 'version': [3795, 3812, 4436], 'present': [3803], '(Fig.4A).': [3806], 'tagged': [3811], 'lacking': [3815], '(FishΔPX).': [3819], 'version,': [3827], 'instead': [3835], 'diffuse': [3839], '4B).': [3843], 'partners,': [3871], 'GST-SH3': [3874, 4411], '[35S]methionine-': [3879], '[35S]cysteine-labeled': [3881], 'lysates': [3882, 3895], '(Fig.5).': [3886], 'compared': [3896], 'control.': [3900], 'SH3#1,': [3902], 'SH3#2,': [3903], 'SH3#4': [3905], 'had': [3907], 'limited': [3909], '(visible': [3914], 'longer': [3916], 'exposures),': [3917], 'whereas': [3918, 4433], 'SH3#3': [3919], 'SH3#5': [3921, 4349, 4422], 'broader': [3923], 'capacities.': [3925], 'characterization': [3927], 'comparison': [3929], 'capacity': [3933], 'require': [3939], 'nature': [3945], 'bands.': [3951], 'isolating': [3957], 'characterizing': [3959], 'SH3#5.': [3964], 'Briefly,': [3982], 'made': [3987], 'size-selected,': [3991], 'vector': [3998, 4393, 4395], 'immobilized': [4020], 'GST-SH3#5': [4021], 'conducted': [4026, 4193, 4275], 'successive': [4028], 'rounds': [4029, 4204, 4286], 'panning.': [4032], 'A': [4033, 4270], 'total': [4034, 4107], 'plaques': [4037], 'obtained.': [4039, 4342], 'sequencing': [4047], '(Table': [4048], 'I).': [4049], 'Most': [4050], 'clones': [4051, 4071], 'method': [4061], 'detect': [4065], 'domain-interacting': [4067], 'sequences.': [4068], 'However': [4069], 'encoded': [4072], 'secreted': [4073], '(TIMP-1': [4075], 'SPARC)': [4077], 'unlikely': [4080], 'physiological': [4087], 'setting.': [4088], 'Strikingly,': [4089], 'however,': [4090], 'region': [4095, 4138], 'corresponding': [4096], 'portion': [4099, 4153], '18': [4109], 'second,': [4117], 'independent': [4118], 'further': [4124], 'six': [4125], 'Fig.6A': [4130], 'shows': [4131], 'topography': [4133], 'screen.Table': [4144], 'IPhage': [4145], 'resultsIdentity': [4147], 'cloneNo.': [4149], 'obtainedCommentsADAM1918C-terminal': [4152], 'region,': [4156], 'motifs.TIMP-11C-terminal': [4159], 'portion,': [4160, 4166], 'motif.': [4163, 4169], 'Secreted': [4164, 4170], 'protein.SPARC1C-terminal': [4165], 'protein.Novel1Three': [4171], 'motifs.': [4173], '舒1-a舒,': [4174], 'determined.2Background.': [4176], 'Only': [4177], 'capsid': [4185], 'protein.': [4186], '舒1Sequence': [4187], 'failed.A': [4188], 'under': [4196, 4278], '“Experimental': [4197, 4279], 'Procedures.”': [4198, 4280], 'At': [4199, 4281], 'end': [4201, 4283, 4365], 'column.': [4232, 4314], 'column': [4235, 4250, 4317, 4332], 'denotes': [4236, 4318], 'how': [4237, 4319], 'isolates': [4243, 4325], 'provides': [4251, 4333], 'information': [4253, 4335], 'identity': [4256, 4338], 'obtained.1-a': [4260], '舒,': [4261], 'determined.': [4263], 'Open': [4264], 'table': [4265], 'new': [4268], 'tab': [4269], 'vitro,': [4356], 'engineered': [4358], 'myc': [4360], 'tag': [4361], '5′': [4364], '(PD19)': [4374], 'vector.': [4382], 'either': [4391], 'empty': [4392], 'myc-tagged': [4397, 4428, 4469, 4483], 'PD19.': [4398], 'Lysates': [4399], 'passed': [4404], '6B).': [4421], 'PD19': [4429, 4484], 'assay,': [4432], 'point-mutated': [4435], 'ligand': [4440], 'disrupted': [4444], 'mutation': [4446], 'tryptophan': [4448], '1056': [4449], 'alanine': [4451], '(mSH3#5)': [4452], 'not.': [4454], 'none': [4456], 'PD19,': [4470], 'demonstrating': [4471], 'specificity': [4473], 'interaction.': [4476], 'separate': [4478], 'experiments,': [4479], 'mSH3#5': [4500]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2064750103', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 18}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 16}, {'year': 2014, 'cited_by_count': 17}, {'year': 2013, 'cited_by_count': 12}, {'year': 2012, 'cited_by_count': 16}], 'updated_date': '2025-01-04T20:57:50.191616', 'created_date': '2016-06-24'}
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