Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2064442490', 'doi': 'https://doi.org/10.1016/j.molcel.2014.05.015', 'title': 'Cancer Epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance', 'display_name': 'Cancer Epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance', 'publication_year': 2014, 'publication_date': '2014-06-01', 'ids': {'openalex': 'https://openalex.org/W2064442490', 'doi': 'https://doi.org/10.1016/j.molcel.2014.05.015', 'mag': '2064442490', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24905005', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4103691'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.molcel.2014.05.015', 'pdf_url': 'http://www.cell.com/article/S1097276514004092/pdf', 'source': {'id': 'https://openalex.org/S156208185', 'display_name': 'Molecular Cell', 'issn_l': '1097-2765', 'issn': ['1097-2765', '1097-4164'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.cell.com/article/S1097276514004092/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5034057788', 'display_name': 'Hariharan Easwaran', 'orcid': 'https://orcid.org/0000-0002-5517-2972'}, 'institutions': [{'id': 'https://openalex.org/I4210164401', 'display_name': 'Sidney Kimmel Comprehensive Cancer Center', 'ror': 'https://ror.org/05m5b8x20', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I2799853436', 'https://openalex.org/I4210164401']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hariharan Easwaran', 'raw_affiliation_strings': ['The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.'], 'affiliations': [{'raw_affiliation_string': 'The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.', 'institution_ids': ['https://openalex.org/I4210164401', 'https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102728960', 'display_name': 'Hsing-Chen Tsai', 'orcid': 'https://orcid.org/0000-0002-7057-9084'}, 'institutions': [{'id': 'https://openalex.org/I4210164401', 'display_name': 'Sidney Kimmel Comprehensive Cancer Center', 'ror': 'https://ror.org/05m5b8x20', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I2799853436', 'https://openalex.org/I4210164401']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hsing-Chen Tsai', 'raw_affiliation_strings': ['The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.'], 'affiliations': [{'raw_affiliation_string': 'The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.', 'institution_ids': ['https://openalex.org/I4210164401', 'https://openalex.org/I145311948']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5085782600', 'display_name': 'Baylin Sb', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210164401', 'display_name': 'Sidney Kimmel Comprehensive Cancer Center', 'ror': 'https://ror.org/05m5b8x20', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I2799853436', 'https://openalex.org/I4210164401']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stephen\xa0B. Baylin', 'raw_affiliation_strings': ['The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.'], 'affiliations': [{'raw_affiliation_string': 'The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.', 'institution_ids': ['https://openalex.org/I4210164401', 'https://openalex.org/I145311948']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 9080, 'currency': 'USD', 'value_usd': 9080, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 8.766, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 814, 'citation_normalized_percentile': {'value': 0.999748, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '54', 'issue': '5', 'first_page': '716', 'last_page': '727'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetic Modifications and Their Functional Implications', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetic Modifications and Their Functional Implications', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11287', 'display_name': 'Genomic Landscape of Cancer and Mutational Signatures', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10492', 'display_name': 'Regulation and Function of Microtubules in Cell Division', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cancer-epigenetics', 'display_name': 'Cancer Epigenetics', 'score': 0.669089}, {'id': 'https://openalex.org/keywords/epigenesis', 'display_name': 'Epigenesis', 'score': 0.5847376}, {'id': 'https://openalex.org/keywords/intratumor-heterogeneity', 'display_name': 'Intratumor Heterogeneity', 'score': 0.578761}, {'id': 'https://openalex.org/keywords/tumor-evolution', 'display_name': 'Tumor Evolution', 'score': 0.560798}, {'id': 'https://openalex.org/keywords/cancer-genomics', 'display_name': 'Cancer Genomics', 'score': 0.532446}, {'id': 'https://openalex.org/keywords/epigenetic-therapy', 'display_name': 'Epigenetic Therapy', 'score': 0.516038}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8789996}, {'id': 'https://openalex.org/C41091548', 'wikidata': 'https://www.wikidata.org/wiki/Q26939', 'display_name': 'Epigenetics', 'level': 3, 'score': 0.8565567}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.7634795}, {'id': 'https://openalex.org/C55427017', 'wikidata': 'https://www.wikidata.org/wiki/Q1638475', 'display_name': 'Cancer stem cell', 'level': 3, 'score': 0.65409184}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.61289674}, {'id': 'https://openalex.org/C179463898', 'wikidata': 'https://www.wikidata.org/wiki/Q10273301', 'display_name': 'Epigenesis', 'level': 5, 'score': 0.5847376}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.55180866}, {'id': 'https://openalex.org/C113968399', 'wikidata': 'https://www.wikidata.org/wiki/Q7559241', 'display_name': 'Somatic evolution in cancer', 'level': 3, 'score': 0.5207686}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.51806855}, {'id': 'https://openalex.org/C64618202', 'wikidata': 'https://www.wikidata.org/wiki/Q3733697', 'display_name': 'Genetic heterogeneity', 'level': 4, 'score': 0.50933397}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.4248414}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.37862983}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.3650218}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.28866893}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.18337032}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.09450254}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.05862519}], 'mesh': [{'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D044127', 'descriptor_name': 'Epigenesis, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D063646', 'descriptor_name': 'Carcinogenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D063646', 'descriptor_name': 'Carcinogenesis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.molcel.2014.05.015', 'pdf_url': 'http://www.cell.com/article/S1097276514004092/pdf', 'source': {'id': 'https://openalex.org/S156208185', 'display_name': 'Molecular Cell', 'issn_l': '1097-2765', 'issn': ['1097-2765', '1097-4164'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4103691', 'pdf_url': 'https://europepmc.org/articles/pmc4103691?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103691', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24905005', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.molcel.2014.05.015', 'pdf_url': 'http://www.cell.com/article/S1097276514004092/pdf', 'source': {'id': 'https://openalex.org/S156208185', 'display_name': 'Molecular Cell', 'issn_l': '1097-2765', 'issn': ['1097-2765', '1097-4164'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.71, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 106, 'referenced_works': ['https://openalex.org/W1528704815', 'https://openalex.org/W1894632965', 'https://openalex.org/W1963795009', 'https://openalex.org/W1964081206', 'https://openalex.org/W1965766641', 'https://openalex.org/W1967304777', 'https://openalex.org/W1968931043', 'https://openalex.org/W1969670934', 'https://openalex.org/W1978154786', 'https://openalex.org/W1980937575', 'https://openalex.org/W1984328011', 'https://openalex.org/W1984562049', 'https://openalex.org/W1985264867', 'https://openalex.org/W1986167448', 'https://openalex.org/W1988756388', 'https://openalex.org/W1991025954', 'https://openalex.org/W1992294066', 'https://openalex.org/W1994292200', 'https://openalex.org/W1995105508', 'https://openalex.org/W1998728654', 'https://openalex.org/W1999478182', 'https://openalex.org/W2000156285', 'https://openalex.org/W2007957281', 'https://openalex.org/W2008878539', 'https://openalex.org/W2011376261', 'https://openalex.org/W2014359105', 'https://openalex.org/W2023005251', 'https://openalex.org/W2023560061', 'https://openalex.org/W2030523067', 'https://openalex.org/W2032518018', 'https://openalex.org/W2032951366', 'https://openalex.org/W2034879676', 'https://openalex.org/W2035151737', 'https://openalex.org/W2035409103', 'https://openalex.org/W2040827479', 'https://openalex.org/W2041686632', 'https://openalex.org/W2042087070', 'https://openalex.org/W2042471142', 'https://openalex.org/W2044433401', 'https://openalex.org/W2045297101', 'https://openalex.org/W2058569154', 'https://openalex.org/W2059300459', 'https://openalex.org/W2060383229', 'https://openalex.org/W2063296278', 'https://openalex.org/W2065498897', 'https://openalex.org/W2069536617', 'https://openalex.org/W2073483289', 'https://openalex.org/W2076399666', 'https://openalex.org/W2078972833', 'https://openalex.org/W2080452140', 'https://openalex.org/W2080856070', 'https://openalex.org/W2082477824', 'https://openalex.org/W2084699632', 'https://openalex.org/W2085136169', 'https://openalex.org/W2092308103', 'https://openalex.org/W2095718447', 'https://openalex.org/W2097009498', 'https://openalex.org/W2101366183', 'https://openalex.org/W2105528101', 'https://openalex.org/W2106391833', 'https://openalex.org/W2109528445', 'https://openalex.org/W2110511887', 'https://openalex.org/W2111163869', 'https://openalex.org/W2111627225', 'https://openalex.org/W2114912562', 'https://openalex.org/W2117247812', 'https://openalex.org/W2119516652', 'https://openalex.org/W2122953117', 'https://openalex.org/W2124042578', 'https://openalex.org/W2125154191', 'https://openalex.org/W2126163659', 'https://openalex.org/W2126665584', 'https://openalex.org/W2126817554', 'https://openalex.org/W2128011911', 'https://openalex.org/W2128146359', 'https://openalex.org/W2129375080', 'https://openalex.org/W2130552015', 'https://openalex.org/W2131860315', 'https://openalex.org/W2135007436', 'https://openalex.org/W2135449253', 'https://openalex.org/W2135656436', 'https://openalex.org/W2136367995', 'https://openalex.org/W2137846548', 'https://openalex.org/W2141476381', 'https://openalex.org/W2142261306', 'https://openalex.org/W2143995836', 'https://openalex.org/W2145824104', 'https://openalex.org/W2148064779', 'https://openalex.org/W2148834831', 'https://openalex.org/W2150575159', 'https://openalex.org/W2151948621', 'https://openalex.org/W2153899606', 'https://openalex.org/W2154313451', 'https://openalex.org/W2158900087', 'https://openalex.org/W2163235555', 'https://openalex.org/W2167638513', 'https://openalex.org/W2168303063', 'https://openalex.org/W2168889003', 'https://openalex.org/W2169895148', 'https://openalex.org/W2169903102', 'https://openalex.org/W2170079803', 'https://openalex.org/W2170210082', 'https://openalex.org/W2259938310', 'https://openalex.org/W2280718773', 'https://openalex.org/W2519244818', 'https://openalex.org/W4235541467'], 'related_works': ['https://openalex.org/W4379517748', 'https://openalex.org/W3004333165', 'https://openalex.org/W2796298565', 'https://openalex.org/W2527574140', 'https://openalex.org/W2488545743', 'https://openalex.org/W2306525395', 'https://openalex.org/W2082768186', 'https://openalex.org/W2063957403', 'https://openalex.org/W2031458863', 'https://openalex.org/W2022797399'], 'abstract_inverted_index': {'The': [0, 106], 'existence': [1, 107], 'of': [2, 4, 27, 37, 45, 58, 83, 98, 103, 108, 110, 133, 143, 151, 164, 189, 204, 209], 'subpopulations': [3, 109], 'cells': [5, 111], 'in': [6, 71, 91, 95, 101, 112, 177, 197, 201, 207], 'cancers': [7, 102, 113, 208], 'with': [8, 114], 'increased': [9, 115], 'tumor-initiating': [10, 116], 'capacities': [11, 117], 'and': [12, 24, 42, 94, 118, 130, 148, 200], 'self-renewal': [13, 119], 'potential,': [14, 120], 'often': [15, 121], 'termed': [16, 122], '“cancer': [17, 123], 'stem': [18, 124], 'cells,”': [19, 125], 'is': [20, 33, 51, 54, 126, 139, 157, 160], 'a': [21, 72, 127, 178], 'much': [22, 128], 'discussed': [23, 129], 'key': [25, 131], 'area': [26, 132], 'cancer': [28, 134], 'biology.': [29, 135], 'Such': [30, 136], 'cellular': [31, 99, 137, 205], 'heterogeneity': [32, 100, 138, 206], 'very': [34, 140], 'important': [35, 141], 'because': [36, 142], 'its': [38, 144], 'impact': [39, 145], 'on': [40, 146], 'therapy': [41, 147], 'especially': [43, 149], 'states': [44, 61, 150, 167], 'treatment': [46, 152], 'resistance.': [47, 153], 'A': [48, 154], 'major': [49, 155], 'question': [50, 156], 'whether': [52, 158], 'there': [53, 159], 'plasticity': [55, 161], 'for': [56, 162], 'evolution': [57, 163], 'these': [59, 165], 'cell': [60, 69, 166, 175], 'during': [62, 168], 'tumorigenesis': [63, 169], 'that': [64, 170], 'can': [65, 171], 'involve': [66, 172], 'movement': [67, 173], 'between': [68, 174], 'populations': [70, 176], 'reversible': [73, 179], 'fashion.': [74, 180], 'In': [75, 181], 'this': [76, 182], 'review,': [77, 183], 'we': [78, 184], 'discuss': [79, 185], 'the': [80, 96, 186, 202], 'possible': [81, 187], 'role': [82, 188], 'epigenetic': [84, 190], 'abnormalities': [85, 191], 'as': [86, 88, 192, 194], 'well': [87, 193], 'genetic': [89, 195], 'alterations': [90, 196], 'such': [92, 198], 'dynamics': [93, 199], 'creation': [97, 203], 'all': [104, 210], 'types.': [105, 211]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2064442490', 'counts_by_year': [{'year': 2024, 'cited_by_count': 37}, {'year': 2023, 'cited_by_count': 60}, {'year': 2022, 'cited_by_count': 94}, {'year': 2021, 'cited_by_count': 99}, {'year': 2020, 'cited_by_count': 107}, {'year': 2019, 'cited_by_count': 101}, {'year': 2018, 'cited_by_count': 87}, {'year': 2017, 'cited_by_count': 66}, {'year': 2016, 'cited_by_count': 67}, {'year': 2015, 'cited_by_count': 77}, {'year': 2014, 'cited_by_count': 14}], 'updated_date': '2024-09-19T00:01:41.045710', 'created_date': '2016-06-24'}