Title: Dual Recognition of Double-Stranded DNA by 2′-Aminoethoxy-Modified Oligonucleotides
Abstract:Simultaneous interaction of the 2′-aminoethoxy-modified oligonucleotides with the phosphodiester backbone (shown on the right, A) and with the bases through Hoogsteen base contacts (B) is seen at each...Simultaneous interaction of the 2′-aminoethoxy-modified oligonucleotides with the phosphodiester backbone (shown on the right, A) and with the bases through Hoogsteen base contacts (B) is seen at each base-pair step of the duplex DNA target. The electrostatic interaction between the protonated amino group and the negatively charged phosphate group provides for a dramatic increase in the binding affinity and the association rate constant.Read More
Publication Year: 1998
Publication Date: 1998-05-18
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 130
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