Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2064272156', 'doi': 'https://doi.org/10.1038/sj.onc.1210159', 'title': 'Semaxinib (SU5416) as a therapeutic agent targeting oncogenic Kit mutants resistant to imatinib mesylate', 'display_name': 'Semaxinib (SU5416) as a therapeutic agent targeting oncogenic Kit mutants resistant to imatinib mesylate', 'publication_year': 2006, 'publication_date': '2006-12-18', 'ids': {'openalex': 'https://openalex.org/W2064272156', 'doi': 'https://doi.org/10.1038/sj.onc.1210159', 'mag': '2064272156', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17173066'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/sj.onc.1210159', 'pdf_url': 'https://www.nature.com/articles/1210159.pdf', 'source': {'id': 'https://openalex.org/S128439998', 'display_name': 'Oncogene', 'issn_l': '0950-9232', 'issn': ['0950-9232', '1476-5594'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.nature.com/articles/1210159.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5018074362', 'display_name': 'Olivier Kosmider', 'orcid': 'https://orcid.org/0000-0002-6021-4057'}, 'institutions': [{'id': 'https://openalex.org/I80043', 'display_name': 'Institut Curie', 'ror': 'https://ror.org/04t0gwh46', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I80043']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'O Kosmider', 'raw_affiliation_strings': ['Inserm U528, Institut Curie, Paris cedex 05, France'], 'affiliations': [{'raw_affiliation_string': 'Inserm U528, Institut Curie, Paris cedex 05, France', 'institution_ids': ['https://openalex.org/I80043', 'https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091739048', 'display_name': 'Nicole Denis', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I80043', 'display_name': 'Institut Curie', 'ror': 'https://ror.org/04t0gwh46', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I80043']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'N Denis', 'raw_affiliation_strings': ['Inserm U528, Institut Curie, Paris cedex 05, France'], 'affiliations': [{'raw_affiliation_string': 'Inserm U528, Institut Curie, Paris cedex 05, France', 'institution_ids': ['https://openalex.org/I80043', 'https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056713429', 'display_name': 'Patrice Dubreuil', 'orcid': 'https://orcid.org/0000-0003-1155-1150'}, 'institutions': [{'id': 'https://openalex.org/I4210150365', 'display_name': 'Institut Paoli-Calmettes', 'ror': 'https://ror.org/04s3t1g37', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210150365']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'P Dubreuil', 'raw_affiliation_strings': ['UMR 599 Inserm, Institut Paoli-Calmettes, Marseille, France'], 'affiliations': [{'raw_affiliation_string': 'UMR 599 Inserm, Institut Paoli-Calmettes, Marseille, France', 'institution_ids': ['https://openalex.org/I4210150365', 'https://openalex.org/I154526488']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5001783489', 'display_name': 'Françoise Moreau-Gachelin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I80043', 'display_name': 'Institut Curie', 'ror': 'https://ror.org/04t0gwh46', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I80043']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'F Moreau-Gachelin', 'raw_affiliation_strings': ['Inserm U528, Institut Curie, Paris cedex 05, France'], 'affiliations': [{'raw_affiliation_string': 'Inserm U528, Institut Curie, Paris cedex 05, France', 'institution_ids': ['https://openalex.org/I80043', 'https://openalex.org/I154526488']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4390, 'currency': 'EUR', 'value_usd': 5490, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.184, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 25, 'citation_normalized_percentile': {'value': 0.808707, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '26', 'issue': '26', 'first_page': '3904', 'last_page': '3908'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11215', 'display_name': 'Efficacy and Resistance in CML Treatment', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11215', 'display_name': 'Efficacy and Resistance in CML Treatment', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11346', 'display_name': 'Role of Mast Cells in Immunoregulation and Disease', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10746', 'display_name': 'Platelet Disorders and Thrombosis Mechanisms', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/imatinib-mesylate', 'display_name': 'Imatinib mesylate', 'score': 0.86010206}, {'id': 'https://openalex.org/keywords/tyrosine-kinase-inhibitors', 'display_name': 'Tyrosine Kinase Inhibitors', 'score': 0.486061}, {'id': 'https://openalex.org/keywords/proto-oncogene-proteins-c-kit', 'display_name': 'Proto-Oncogene Proteins c-kit', 'score': 0.46732345}], 'concepts': [{'id': 'https://openalex.org/C3019892230', 'wikidata': 'https://www.wikidata.org/wiki/Q177094', 'display_name': 'Imatinib mesylate', 'level': 4, 'score': 0.86010206}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6941267}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6393626}, {'id': 'https://openalex.org/C42362537', 'wikidata': 'https://www.wikidata.org/wiki/Q87099740', 'display_name': 'Tyrosine kinase', 'level': 3, 'score': 0.5614299}, {'id': 'https://openalex.org/C2777583451', 'wikidata': 'https://www.wikidata.org/wiki/Q177094', 'display_name': 'Imatinib', 'level': 3, 'score': 0.52479446}, {'id': 'https://openalex.org/C2778729363', 'wikidata': 'https://www.wikidata.org/wiki/Q11688946', 'display_name': 'Myeloid leukemia', 'level': 2, 'score': 0.50511485}, {'id': 'https://openalex.org/C2910840531', 'wikidata': 'https://www.wikidata.org/wiki/Q909409', 'display_name': 'Proto-Oncogene Proteins c-kit', 'level': 5, 'score': 0.46732345}, {'id': 'https://openalex.org/C101544691', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor tyrosine kinase', 'level': 3, 'score': 0.45392132}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.44416848}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.44006926}, {'id': 'https://openalex.org/C2778461978', 'wikidata': 'https://www.wikidata.org/wiki/Q29496', 'display_name': 'Leukemia', 'level': 2, 'score': 0.43275318}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.34719896}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.30761838}, {'id': 'https://openalex.org/C2022786', 'wikidata': 'https://www.wikidata.org/wiki/Q909331', 'display_name': 'Stem cell factor', 'level': 4, 'score': 0.23356754}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.20451206}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.19626448}, {'id': 'https://openalex.org/C109159458', 'wikidata': 'https://www.wikidata.org/wiki/Q919283', 'display_name': 'Haematopoiesis', 'level': 3, 'score': 0.19481456}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.16084892}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.14233708}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.11227009}], 'mesh': [{'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011758', 'descriptor_name': 'Pyrroles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D019089', 'descriptor_name': 'Stem Cell Factor', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D019089', 'descriptor_name': 'Stem Cell Factor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D001549', 'descriptor_name': 'Benzamides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004900', 'descriptor_name': 'Erythroblasts', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004900', 'descriptor_name': 'Erythroblasts', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004900', 'descriptor_name': 'Erythroblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048049', 'descriptor_name': 'Extracellular Signal-Regulated MAP Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D048049', 'descriptor_name': 'Extracellular Signal-Regulated MAP Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048049', 'descriptor_name': 'Extracellular Signal-Regulated MAP Kinases', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000068877', 'descriptor_name': 'Imatinib Mesylate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051058', 'descriptor_name': 'Oncogene Protein v-akt', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051058', 'descriptor_name': 'Oncogene Protein v-akt', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051058', 'descriptor_name': 'Oncogene Protein v-akt', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011758', 'descriptor_name': 'Pyrroles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050796', 'descriptor_name': 'STAT3 Transcription Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050796', 'descriptor_name': 'STAT3 Transcription Factor', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D050796', 'descriptor_name': 'STAT3 Transcription Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019089', 'descriptor_name': 'Stem Cell Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/sj.onc.1210159', 'pdf_url': 'https://www.nature.com/articles/1210159.pdf', 'source': {'id': 'https://openalex.org/S128439998', 'display_name': 'Oncogene', 'issn_l': '0950-9232', 'issn': ['0950-9232', '1476-5594'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17173066', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/sj.onc.1210159', 'pdf_url': 'https://www.nature.com/articles/1210159.pdf', 'source': {'id': 'https://openalex.org/S128439998', 'display_name': 'Oncogene', 'issn_l': '0950-9232', 'issn': ['0950-9232', '1476-5594'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.84, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 24, 'referenced_works': ['https://openalex.org/W11751756', 'https://openalex.org/W1480076252', 'https://openalex.org/W1951359666', 'https://openalex.org/W2037934019', 'https://openalex.org/W2038961612', 'https://openalex.org/W2048993739', 'https://openalex.org/W2053314612', 'https://openalex.org/W2053690380', 'https://openalex.org/W2055763832', 'https://openalex.org/W2064435481', 'https://openalex.org/W2081007495', 'https://openalex.org/W2095023562', 'https://openalex.org/W2095226581', 'https://openalex.org/W2101808949', 'https://openalex.org/W2101886636', 'https://openalex.org/W2102185636', 'https://openalex.org/W2109399667', 'https://openalex.org/W2118781121', 'https://openalex.org/W2134094496', 'https://openalex.org/W2146310502', 'https://openalex.org/W2149923229', 'https://openalex.org/W2155591820', 'https://openalex.org/W2166825418', 'https://openalex.org/W2171620774'], 'related_works': ['https://openalex.org/W2903363945', 'https://openalex.org/W2902072959', 'https://openalex.org/W2414149210', 'https://openalex.org/W2140626630', 'https://openalex.org/W2135874746', 'https://openalex.org/W2122109577', 'https://openalex.org/W2066018157', 'https://openalex.org/W2061493553', 'https://openalex.org/W2028346583', 'https://openalex.org/W1611450479'], 'abstract_inverted_index': {'Activating': [0], 'mutations': [1, 132], 'in': [2, 9, 31, 37, 74], 'the': [3, 32, 79, 92, 97], 'Kit': [4, 13, 44, 59, 102, 130], 'receptor': [5], 'are': [6, 134], 'frequently': [7], 'observed': [8], 'various': [10], 'malignancies,': [11], 'pointing': [12], 'as': [14, 34], 'a': [15, 121], 'molecule': [16], 'of': [17, 91, 99, 106], 'interest': [18], 'for': [19], 'drug': [20], 'inhibition.': [21], 'When': [22], 'mutated': [23, 60], 'on': [24], 'Asp': [25, 29], '816': [26], '(corresponding': [27], 'to': [28, 47, 124, 136], '814': [30, 63], 'mouse),': [33], 'preferentially': [35], 'found': [36], 'human': [38], 'mastocytosis': [39], 'and': [40, 88, 104, 109], 'acute': [41], 'myeloid': [42], 'leukemia,': [43], 'became': [45], 'non-sensitive': [46], 'imatinib': [48, 139], 'mesylate': [49], '(Gleevec).': [50], 'Erythroleukemic': [51], 'cells': [52, 73, 127], 'isolated': [53], 'from': [54], 'Spi-1/PU.1': [55], 'transgenic': [56], 'mice': [57], 'express': [58], 'at': [61], 'codon': [62, 68], '(KitD814Y': [64], 'or': [65, 67], 'KitD814V)': [66], '818': [69], '(KitD818Y).': [70], 'Using': [71], 'these': [72], 'vitro,': [75], 'we': [76], 'demonstrate': [77], 'that': [78, 117, 133], 'tyrosine': [80], 'kinase': [81], 'inhibitor': [82], 'SU5416': [83, 118], '(Semaxinib)': [84], 'induces': [85], 'growth': [86], 'arrest': [87], 'apoptosis': [89], 'independent': [90], 'mutation': [93], 'type': [94], 'by': [95, 129], 'inhibiting': [96], 'functions': [98], 'Kit,': [100], 'including': [101], 'autophosphorylation': [103], 'activation': [105], 'Akt,': [107], 'Erk1/Erk2': [108], 'Stat3': [110], 'downstream': [111], 'signaling': [112], 'pathways.': [113], 'These': [114], 'findings': [115], 'indicate': [116], 'may': [119], 'be': [120], 'promising': [122], 'tool': [123], 'kill': [125], 'cancer': [126], 'driven': [128], 'oncogenic': [131], 'resistant': [135], 'treatment': [137], 'with': [138], 'mesylate.': [140]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2064272156', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-08-13T12:43:23.415988', 'created_date': '2016-06-24'}