Publication Information

{'id': 'https://openalex.org/W2064253914', 'doi': 'https://doi.org/10.1242/jcs.083659', 'title': 'BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development', 'display_name': 'BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development', 'publication_year': 2011, 'publication_date': '2011-10-08', 'ids': {'openalex': 'https://openalex.org/W2064253914', 'doi': 'https://doi.org/10.1242/jcs.083659', 'mag': '2064253914', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21984813', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3196857'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1242/jcs.083659', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S5677253', 'display_name': 'Journal of Cell Science', 'issn_l': '0021-9533', 'issn': ['0021-9533', '1477-9137'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc3196857', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5070434593', 'display_name': 'Bing Shu', 'orcid': 'https://orcid.org/0000-0002-6009-5377'}, 'institutions': [{'id': 'https://openalex.org/I5388228', 'display_name': 'University of Rochester', 'ror': 'https://ror.org/022kthw22', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I5388228']}, {'id': 'https://openalex.org/I4210101984', 'display_name': 'Longhua Hospital Shanghai University of Traditional Chinese Medicine', 'ror': 'https://ror.org/016yezh07', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210101984']}, {'id': 'https://openalex.org/I4210098460', 'display_name': 'Shanghai University of Traditional Chinese Medicine', 'ror': 'https://ror.org/00z27jk27', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210098460']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'Bing Shu', 'raw_affiliation_strings': ['Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, NY 14642, USA', 'Spine Research Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, NY 14642, USA', 'institution_ids': ['https://openalex.org/I5388228']}, {'raw_affiliation_string': 'Spine Research Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China', 'institution_ids': ['https://openalex.org/I4210101984', 'https://openalex.org/I4210098460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100447285', 'display_name': 'Ming Zhang', 'orcid': 'https://orcid.org/0000-0002-6032-7262'}, 'institutions': [{'id': 'https://openalex.org/I5388228', 'display_name': 'University of Rochester', 'ror': 'https://ror.org/022kthw22', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I5388228']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ming Zhang', 'raw_affiliation_strings': ['Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, NY 14642, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, NY 14642, USA', 'institution_ids': ['https://openalex.org/I5388228']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027587546', 'display_name': 'Rong Xie', 'orcid': 'https://orcid.org/0000-0002-8277-7280'}, 'institutions': [{'id': 'https://openalex.org/I5388228', 'display_name': 'University of Rochester', 'ror': 'https://ror.org/022kthw22', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I5388228']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rong Xie', 'raw_affiliation_strings': ['Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, NY 14642, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, NY 14642, USA', 'institution_ids': ['https://openalex.org/I5388228']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101736623', 'display_name': 'Meina Wang', 'orcid': 'https://orcid.org/0000-0002-2901-062X'}, 'institutions': [{'id': 'https://openalex.org/I5388228', 'display_name': 'University of Rochester', 'ror': 'https://ror.org/022kthw22', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I5388228']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Meina Wang', 'raw_affiliation_strings': ['Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, NY 14642, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, NY 14642, USA', 'institution_ids': ['https://openalex.org/I5388228']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023872965', 'display_name': 'Hongting Jin', 'orcid': 'https://orcid.org/0000-0001-8795-0874'}, 'institutions': [{'id': 'https://openalex.org/I114539943', 'display_name': 'Zhejiang Chinese Medical University', 'ror': 'https://ror.org/04epb4p87', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I114539943']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hongting Jin', 'raw_affiliation_strings': ['Institute of Orthopaedics and Traumatology, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Orthopaedics and Traumatology, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China', 'institution_ids': ['https://openalex.org/I114539943']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100684473', 'display_name': 'Wei Hou', 'orcid': 'https://orcid.org/0000-0003-1439-455X'}, 'institutions': [{'id': 'https://openalex.org/I4210101984', 'display_name': 'Longhua Hospital Shanghai University of Traditional Chinese Medicine', 'ror': 'https://ror.org/016yezh07', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210101984']}, {'id': 'https://openalex.org/I4210098460', 'display_name': 'Shanghai University of Traditional Chinese Medicine', 'ror': 'https://ror.org/00z27jk27', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210098460']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wei Hou', 'raw_affiliation_strings': ['Spine Research Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China'], 'affiliations': [{'raw_affiliation_string': 'Spine Research Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China', 'institution_ids': ['https://openalex.org/I4210101984', 'https://openalex.org/I4210098460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074354350', 'display_name': 'Dezhi Tang', 'orcid': 'https://orcid.org/0000-0002-6528-0731'}, 'institutions': [{'id': 'https://openalex.org/I4210101984', 'display_name': 'Longhua Hospital Shanghai University of Traditional Chinese Medicine', 'ror': 'https://ror.org/016yezh07', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210101984']}, {'id': 'https://openalex.org/I4210098460', 'display_name': 'Shanghai University of Traditional Chinese Medicine', 'ror': 'https://ror.org/00z27jk27', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210098460']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Dezhi Tang', 'raw_affiliation_strings': ['Spine Research Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China'], 'affiliations': [{'raw_affiliation_string': 'Spine Research Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China', 'institution_ids': ['https://openalex.org/I4210101984', 'https://openalex.org/I4210098460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103277401', 'display_name': 'Stephen E. Harris', 'orcid': 'https://orcid.org/0000-0002-5658-9024'}, 'institutions': [{'id': 'https://openalex.org/I165951966', 'display_name': 'The University of Texas Health Science Center at San Antonio', 'ror': 'https://ror.org/02f6dcw23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165951966']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stephen E. Harris', 'raw_affiliation_strings': ['Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA', 'institution_ids': ['https://openalex.org/I165951966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059882947', 'display_name': 'Yuji Mishina', 'orcid': 'https://orcid.org/0000-0002-6268-4204'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yuji Mishina', 'raw_affiliation_strings': ['Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024783120', 'display_name': 'Regis J. O’Keefe', 'orcid': 'https://orcid.org/0000-0003-4055-0368'}, 'institutions': [{'id': 'https://openalex.org/I5388228', 'display_name': 'University of Rochester', 'ror': 'https://ror.org/022kthw22', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I5388228']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': "Regis J. O'Keefe", 'raw_affiliation_strings': ['Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, NY 14642, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, NY 14642, USA', 'institution_ids': ['https://openalex.org/I5388228']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058120580', 'display_name': 'Matthew J. Hilton', 'orcid': 'https://orcid.org/0000-0003-3165-267X'}, 'institutions': [{'id': 'https://openalex.org/I5388228', 'display_name': 'University of Rochester', 'ror': 'https://ror.org/022kthw22', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I5388228']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Matthew J. Hilton', 'raw_affiliation_strings': ['Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, NY 14642, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, NY 14642, USA', 'institution_ids': ['https://openalex.org/I5388228']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100424203', 'display_name': 'Yongjun Wang', 'orcid': 'https://orcid.org/0000-0001-9333-2423'}, 'institutions': [{'id': 'https://openalex.org/I4210101984', 'display_name': 'Longhua Hospital Shanghai University of Traditional Chinese Medicine', 'ror': 'https://ror.org/016yezh07', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210101984']}, {'id': 'https://openalex.org/I4210098460', 'display_name': 'Shanghai University of Traditional Chinese Medicine', 'ror': 'https://ror.org/00z27jk27', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210098460']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yongjun Wang', 'raw_affiliation_strings': ['Spine Research Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China'], 'affiliations': [{'raw_affiliation_string': 'Spine Research Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China', 'institution_ids': ['https://openalex.org/I4210101984', 'https://openalex.org/I4210098460']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100368468', 'display_name': 'Di Chen', 'orcid': 'https://orcid.org/0000-0002-9854-8685'}, 'institutions': [{'id': 'https://openalex.org/I5388228', 'display_name': 'University of Rochester', 'ror': 'https://ror.org/022kthw22', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I5388228']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Di Chen', 'raw_affiliation_strings': ['Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, NY 14642, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, NY 14642, USA', 'institution_ids': ['https://openalex.org/I5388228']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 6, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 12.657, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 238, 'citation_normalized_percentile': {'value': 0.898201, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '124', 'issue': '20', 'first_page': '3428', 'last_page': '3440'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10105', 'display_name': 'Osteoarthritis Treatment and Mechanisms', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10105', 'display_name': 'Osteoarthritis Treatment and Mechanisms', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11501', 'display_name': 'TGF-β signaling in diseases', 'score': 0.9957, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10831', 'display_name': 'Cell Adhesion Molecules Research', 'score': 0.9924, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/runx2', 'display_name': 'RUNX2', 'score': 0.8312219}, {'id': 'https://openalex.org/keywords/conditional-gene-knockout', 'display_name': 'Conditional gene knockout', 'score': 0.7950196}, {'id': 'https://openalex.org/keywords/endochondral-ossification', 'display_name': 'Endochondral ossification', 'score': 0.7237945}, {'id': 'https://openalex.org/keywords/gene-knockout', 'display_name': 'Gene knockout', 'score': 0.43337297}], 'concepts': [{'id': 'https://openalex.org/C2781403057', 'wikidata': 'https://www.wikidata.org/wiki/Q775480', 'display_name': 'Chondrocyte', 'level': 3, 'score': 0.86553496}, {'id': 'https://openalex.org/C2776363554', 'wikidata': 'https://www.wikidata.org/wiki/Q14907085', 'display_name': 'RUNX2', 'level': 4, 'score': 0.8312219}, {'id': 'https://openalex.org/C30352789', 'wikidata': 'https://www.wikidata.org/wiki/Q14903153', 'display_name': 'Bone morphogenetic protein 2', 'level': 3, 'score': 0.80546725}, {'id': 'https://openalex.org/C164659718', 'wikidata': 'https://www.wikidata.org/wiki/Q5159266', 'display_name': 'Conditional gene knockout', 'level': 4, 'score': 0.7950196}, {'id': 'https://openalex.org/C17938293', 'wikidata': 'https://www.wikidata.org/wiki/Q3312710', 'display_name': 'Endochondral ossification', 'level': 3, 'score': 0.7237945}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6954546}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6551322}, {'id': 'https://openalex.org/C2780550940', 'wikidata': 'https://www.wikidata.org/wiki/Q502730', 'display_name': 'Cartilage', 'level': 2, 'score': 0.4892323}, {'id': 'https://openalex.org/C31507581', 'wikidata': 'https://www.wikidata.org/wiki/Q425383', 'display_name': 'Bone morphogenetic protein', 'level': 3, 'score': 0.43782866}, {'id': 'https://openalex.org/C77957584', 'wikidata': 'https://www.wikidata.org/wiki/Q1133550', 'display_name': 'Gene knockout', 'level': 3, 'score': 0.43337297}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.42108098}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.29657704}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.28683382}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.25000063}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.23342022}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.051323205}], 'mesh': [{'descriptor_ui': 'D001846', 'descriptor_name': 'Bone Development', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D055396', 'descriptor_name': 'Bone Morphogenetic Protein 2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D055415', 'descriptor_name': 'Bone Morphogenetic Protein 4', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019902', 'descriptor_name': 'Chondrocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D050659', 'descriptor_name': 'Core Binding Factor Alpha 1 Subunit', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001846', 'descriptor_name': 'Bone Development', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D055396', 'descriptor_name': 'Bone Morphogenetic Protein 2', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D055396', 'descriptor_name': 'Bone Morphogenetic Protein 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055415', 'descriptor_name': 'Bone Morphogenetic Protein 4', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D055415', 'descriptor_name': 'Bone Morphogenetic Protein 4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048708', 'descriptor_name': 'Cell Growth Processes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D048708', 'descriptor_name': 'Cell Growth Processes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019902', 'descriptor_name': 'Chondrocytes', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D019902', 'descriptor_name': 'Chondrocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050659', 'descriptor_name': 'Core Binding Factor Alpha 1 Subunit', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D050659', 'descriptor_name': 'Core Binding Factor Alpha 1 Subunit', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051358', 'descriptor_name': 'Cyclin-Dependent Kinase 4', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051358', 'descriptor_name': 'Cyclin-Dependent Kinase 4', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051358', 'descriptor_name': 'Cyclin-Dependent Kinase 4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006132', 'descriptor_name': 'Growth Plate', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D006132', 'descriptor_name': 'Growth Plate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010009', 'descriptor_name': 'Osteochondrodysplasias', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010009', 'descriptor_name': 'Osteochondrodysplasias', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011499', 'descriptor_name': 'Protein Processing, Post-Translational', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1242/jcs.083659', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S5677253', 'display_name': 'Journal of Cell Science', 'issn_l': '0021-9533', 'issn': ['0021-9533', '1477-9137'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3196857', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196857', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21984813', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3196857', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 59, 'referenced_works': ['https://openalex.org/W1554847406', 'https://openalex.org/W1937940610', 'https://openalex.org/W1965073410', 'https://openalex.org/W1966725283', 'https://openalex.org/W1968923669', 'https://openalex.org/W1972058354', 'https://openalex.org/W1973950443', 'https://openalex.org/W1976260673', 'https://openalex.org/W1979208896', 'https://openalex.org/W1989073601', 'https://openalex.org/W1991094809', 'https://openalex.org/W1995793343', 'https://openalex.org/W1997359300', 'https://openalex.org/W1999971801', 'https://openalex.org/W2001130710', 'https://openalex.org/W2001660827', 'https://openalex.org/W2003367516', 'https://openalex.org/W2004595514', 'https://openalex.org/W2006055704', 'https://openalex.org/W2006486745', 'https://openalex.org/W2006883902', 'https://openalex.org/W2007873620', 'https://openalex.org/W2012295730', 'https://openalex.org/W2012448313', 'https://openalex.org/W2014861948', 'https://openalex.org/W2020444531', 'https://openalex.org/W2030913739', 'https://openalex.org/W2041745288', 'https://openalex.org/W2042932723', 'https://openalex.org/W2048142624', 'https://openalex.org/W2053675422', 'https://openalex.org/W2058276650', 'https://openalex.org/W2059509871', 'https://openalex.org/W2059557903', 'https://openalex.org/W2066440933', 'https://openalex.org/W2070170734', 'https://openalex.org/W2073833110', 'https://openalex.org/W2087174236', 'https://openalex.org/W2088398635', 'https://openalex.org/W2090685680', 'https://openalex.org/W2092859323', 'https://openalex.org/W2095569986', 'https://openalex.org/W2105745528', 'https://openalex.org/W2107141327', 'https://openalex.org/W2108879229', 'https://openalex.org/W2109455081', 'https://openalex.org/W2110654810', 'https://openalex.org/W2117947328', 'https://openalex.org/W2135917978', 'https://openalex.org/W2135930613', 'https://openalex.org/W2137527329', 'https://openalex.org/W2140403673', 'https://openalex.org/W2154983834', 'https://openalex.org/W2156726032', 'https://openalex.org/W2157293906', 'https://openalex.org/W2165213969', 'https://openalex.org/W2167802527', 'https://openalex.org/W3005951556', 'https://openalex.org/W4319308320'], 'related_works': ['https://openalex.org/W4380670511', 'https://openalex.org/W2132946102', 'https://openalex.org/W2098958335', 'https://openalex.org/W2093800167', 'https://openalex.org/W2083563050', 'https://openalex.org/W2063925613', 'https://openalex.org/W2022214487', 'https://openalex.org/W2004266667', 'https://openalex.org/W1989514551', 'https://openalex.org/W1480838859'], 'abstract_inverted_index': {'The': [0], 'BMP': [1, 179], 'signaling': [2, 180], 'pathway': [3], 'has': [4], 'a': [5, 67, 79, 128], 'crucial': [6], 'role': [7], 'in': [8, 28, 66, 103], 'chondrocyte': [9, 104, 132], 'proliferation': [10], 'and': [11, 25, 39, 45, 57, 85, 99, 107, 126, 145, 157, 163, 175], 'maturation': [12], 'during': [13, 32, 181], 'endochondral': [14], 'bone': [15], 'development.': [16, 183], 'To': [17, 109], 'investigate': [18], 'the': [19, 23, 61, 74, 95, 111, 121, 143, 172], 'specific': [20, 122], 'function': [21], 'of': [22, 55, 73, 92, 131, 155, 160, 178], 'Bmp2': [24, 38, 56, 62, 86], 'Bmp4': [26, 40, 58, 75], 'genes': [27, 59], 'growth': [29, 96], 'plate': [30, 97], 'chondrocytes': [31, 93], 'cartilage': [33, 81, 182], 'development,': [34], 'we': [35, 119], 'generated': [36], 'chondrocyte-specific': [37], 'conditional': [41], 'knockout': [42, 48], '(cKO)': [43], 'mice': [44, 88], 'Bmp2,Bmp4': [46], 'double': [47], '(dKO)': [49], 'mice.': [50], 'We': [51, 134], 'found': [52, 135], 'that': [53, 136], 'deletion': [54, 72], 'or': [60], 'gene': [63, 76], 'alone': [64, 77], 'results': [65], 'severe': [68, 90], 'chondrodysplasia': [69], 'phenotype,': [70], 'whereas': [71], 'produces': [78], 'minor': [80], 'phenotype.': [82], 'Both': [83], 'dKO': [84], 'cKO': [87], 'exhibit': [89], 'disorganization': [91], 'within': [94], 'region': [98], 'display': [100], 'profound': [101], 'defects': [102], 'proliferation,': [105], 'differentiation': [106], 'apoptosis.': [108], 'understand': [110], 'mechanism': [112, 177], 'by': [113], 'which': [114], 'BMP2': [115, 125, 137, 148], 'regulates': [116], 'these': [117], 'processes,': [118], 'explored': [120], 'relationship': [123], 'between': [124], 'Runx2,': [127], 'key': [129], 'regulator': [130], 'differentiation.': [133], 'induces': [138], 'Runx2': [139, 150, 161], 'expression': [140], 'at': [141], 'both': [142], 'transcriptional': [144], 'post-transcriptional': [146], 'levels.': [147], 'enhances': [149], 'protein': [151], 'levels': [152], 'through': [153], 'inhibition': [154], 'CDK4': [156], 'subsequent': [158], 'prevention': [159], 'ubiquitylation': [162], 'proteasomal': [164], 'degradation.': [165], 'Our': [166], 'studies': [167], 'provide': [168], 'novel': [169], 'insights': [170], 'into': [171], 'genetic': [173], 'control': [174], 'molecular': [176]}, 'abstract_inverted_index_v3': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2064253914', 'counts_by_year': [{'year': 2024, 'cited_by_count': 14}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 14}, {'year': 2021, 'cited_by_count': 28}, {'year': 2020, 'cited_by_count': 31}, {'year': 2019, 'cited_by_count': 17}, {'year': 2018, 'cited_by_count': 14}, {'year': 2017, 'cited_by_count': 18}, {'year': 2016, 'cited_by_count': 21}, {'year': 2015, 'cited_by_count': 14}, {'year': 2014, 'cited_by_count': 22}, {'year': 2013, 'cited_by_count': 17}, {'year': 2012, 'cited_by_count': 15}], 'updated_date': '2025-01-18T16:09:08.174845', 'created_date': '2016-06-24'}