Abstract: Annals of NeurologyVolume 49, Issue 4 p. 423-424 Editorial N-Acetyl Aspartate—A Neuronal Marker? Peter B. Barker DPhil, Peter B. Barker DPhil Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MDSearch for more papers by this author Peter B. Barker DPhil, Peter B. Barker DPhil Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MDSearch for more papers by this author First published: 02 April 2001 https://doi.org/10.1002/ana.90Citations: 96Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Martin E, Capone A, Schneider J, et al. Absence of N-acetylaspartate in the human brain: impact on neurospectroscopy? Ann Neurol 2001; 49: 518–521. 2 Stockler S, Holzbach U, Hanefeld F, et al. Creatine deficiency in the brain: a new, treatable inborn error of metabolism. Pediatr Res 1994; 36: 409–413. 3 Hanefeld F, Holzbach U, Kruse B, et al. Diffuse white matter disease in three children: an encephalopathy with unique features on magnetic resonance imaging and proton magnetic resonance spectroscopy. Neuropediatrics 1993; 24: 244–248. 4 Schiffmann R, Moller JR, Trapp BD, et al. Childhood ataxia with diffuse central nervous system hypomyelination [see comments]. Ann Neurol 1994; 35: 331–340. 5 van der Knaap MS, Barth PG, Gabreels FJ, et al. A new leukoencephalopathy with vanishing white matter. Neurology 1997; 48: 845–855. 6 van der Knaap MS, Wevers RA, Struys EA, et al. Leukoencephalopathy associated with a disturbance in the metabolism of polyols. Ann Neurol 1999; 46: 925–928. 7 Tallan HH, Moore S, Stein WH. N-acetyl-L-aspartic acid in brain. J Biol Chem 1956; 219: 257–264. 8 Birken DL, Oldendorf WH. N-acetyl-L-aspartic acid: a literature review of a compound prominent in 1H-NMR spectroscopic studies of brain. Neurosci Biobehav Rev 1989; 13: 23–31. 9 Simmons ML, Frondoza CG, Coyle JT. Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies. Neuroscience 1991; 45: 37–45. 10 Guimaraes A, Schwartz P, Prakash MR, et al. Quantitative in vivo IH nuclear magnetic resonance spectroscopic imaging of neuronal loss in rat brain. Neuroscience 1995; 69: 1095–1101. 11 Strauss I, Williamson JM, Bertram EH, et al. Histological and 1H magnetic resonance spectroscopic imaging analysis of quinolinic acid-induced damage to the rat striatum. Magn Res Med 1997; 37: 24–33. 12 Jung RE, Brooks WM, Yeo RA, et al. Biochemical markers of intelligence: a proton MR spectroscopy study of normal human brain. Proc R Soc Lond B Biol Sci 1999; 266: 1375–1379. 13 Burlina AP, Ferrari V, Facci L, et al. Mast cells contain large quantities of secretagogue-sensitive N-acetylaspartate. J Neurochem 1997; 69: 1314–1317. 14 Urenjak J, Williams SR, Gadian DG, Noble M. Specific expression of N-acetylaspartate in neurons, oligodendrocyte- type-2 astrocyte progenitors, and immature oligodendrocytes in vitro. J Neurochem 1992; 59: 55–61. 15 Bhakoo KK, Pearce D. In vitro expression of N-acetyl aspartate by oligodendrocytes: implications for proton magnetic resonance spectroscopy signal in vivo. J Neurochem 2000; 74: 254–262. 16 Matalon R, Kaul R, Casanova J, et al. SSIEM Award. Aspartoacylase deficiency: the enzyme defect in Canavan disease. J Inherit Metab Dis 1989; 12(Suppl 2): 329–331. 17 de Stefano N, Matthews PM, Arnold DL. Reversible decreases in N-acetylaspartate after acute brain injury. Magn Reson Med 1995; 34: 721–727. 18 Vion-Dury J, Nicoli F, Salvan AM, et al. Reversal of brain metabolic alterations with zidovudine detected by proton localised magnetic resonance spectroscopy [letter]. Lancet 1995; 345: 60–61. 19 Hugg JW, Kuzniecky RI, Gilliam FG, et al. Normalization of contralateral metabolic function following temporal lobectomy demonstrated by H-1 magnetic resonance spectroscopic imaging. Ann Neurol 1996; 40: 236–239. 20 Cendes F, Andermann F, Dubeau F, et al. Normalization of neuronal metabolic dysphunction after surgery for temporal lobe epilepsy. Evidence from proton MR spectroscopic imaging. Neurology 1997; 49: 1525–1533. 21 Kalra S, Cashman NR, Genge A, Arnold DL. Recovery of N-acetylaspartate in corticomotor neurons of patients with ALS after riluzole therapy. Neuroreport 1998; 9: 1757–1761. Citing Literature Volume49, Issue4April 2001Pages 423-424 ReferencesRelatedInformation
Publication Year: 2001
Publication Date: 2001-04-01
Language: en
Type: editorial
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 127
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