Publication Information

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3011, 3032, 3057, 3066, 3076, 3091, 3095, 3117, 3120, 3128, 3164, 3236, 3241, 3250, 3271, 3281, 3305, 3336, 3338, 3348, 3391, 3395, 3456, 3485, 3494, 3497, 3510, 3520, 3544, 3552, 3570, 3630, 3674, 3706, 3733, 3746, 3762, 3792, 3807, 3825, 3876, 3937, 3968, 3988, 4101, 4117, 4133, 4141, 4222, 4244, 4261, 4274, 4347, 4382, 4429, 4434, 4438, 4450], 'transporters.': [21, 167], 'This': [22, 168, 760, 1303, 2753, 3782], 'gene,': [23, 169, 3811], 'termed': [24, 170], 'protein': [27, 138, 173, 284, 302, 317, 821, 1006, 1483, 1578, 2101, 2783, 3183, 4321], '(mtp1),': [28, 174], 'expressed': [30, 54, 176, 200, 2285, 3841, 4164, 4308, 4333, 4425], 'in': [31, 34, 55, 62, 92, 97, 107, 120, 126, 142, 177, 180, 201, 208, 238, 243, 253, 266, 272, 288, 330, 385, 428, 533, 535, 835, 844, 853, 900, 915, 966, 988, 1060, 1126, 1134, 1136, 1150, 1409, 1415, 1449, 1459, 1585, 1640, 1709, 1767, 2056, 2064, 2068, 2075, 2105, 2119, 2129, 2137, 2204, 2210, 2237, 2243, 2259, 2262, 2286, 2291, 2300, 2330, 2351, 2357, 2377, 2398, 2420, 2447, 2453, 2462, 2472, 2478, 2489, 2493, 2559, 2586, 2589, 2630, 2641, 2656, 2707, 2728, 2763, 2798, 2823, 2830, 2833, 2919, 2935, 2939, 2979, 2992, 3000, 3026, 3097, 3111, 3130, 3135, 3154, 3179, 3238, 3340, 3402, 3499, 3547, 3556, 3634, 3730, 3743, 3769, 3784, 3802, 3819, 3827, 3843, 3853, 3880, 3896, 3916, 3924, 3951, 4045, 4057, 4070, 4073, 4080, 4098, 4124, 4130, 4153, 4180, 4196, 4229, 4247, 4253, 4265, 4286, 4309, 4322, 4325, 4334, 4385, 4393, 4410, 4416, 4426, 4441], 'tissues': [32, 178, 2122, 2287, 2491], 'involved': [33, 141, 179, 287, 834, 3110, 3742, 3923, 4079, 4392], 'body': [35, 181, 332, 337, 2413, 3463], 'iron': [36, 99, 144, 182, 245, 290, 322, 338, 342, 349, 487, 492, 507, 516, 541, 586, 672, 686, 695, 702, 709, 771, 836, 842, 866, 883, 919, 2292, 2621, 2800, 2952, 3112, 3147, 3177, 3259, 3295, 3344, 3375, 3382, 3438, 3454, 3464, 3470, 3487, 3493, 3566, 3747, 3755, 3768, 3777, 3791, 3910, 3925, 3939, 3952, 3961, 3973, 3984, 4032, 4071, 4081, 4097, 4108, 4191, 4202, 4231, 4239, 4277, 4294, 4323, 4386, 4395, 4398, 4442, 4452], 'homeostasis': [37, 183], 'including': [38, 184, 2793], 'developing': [40, 186, 2378, 4280, 4412], 'mature': [42, 188, 2131, 3277, 3302], 'reticuloendothelial': [43, 86, 189, 232, 303], 'system,': [44, 190], 'duodenum,': [46, 192, 3558], 'pregnant': [49, 195, 2321, 3243], 'uterus.': [50, 196], 'MTP1': [51, 69, 91, 105, 118, 133, 197, 215, 237, 251, 264, 279, 775, 959, 1026, 1056, 1103, 1186, 1235, 1243, 1247, 1258, 1278, 1293, 1314, 1328, 1342, 1419, 1763, 1832, 1855, 1919, 1947, 2027, 2044, 2100, 2113, 2125, 2283, 2296, 2312, 2336, 2417, 2485, 2511, 2531, 2605, 2624, 2627, 2651, 2677, 2723, 2741, 2804, 2934, 2947, 3040, 3068, 3081, 3096, 3114, 3129, 3237, 3255, 3272, 3339, 3369, 3480, 3498, 3561, 3694, 3739, 3763, 3826, 3839, 3852, 3891, 3906, 3921, 3945, 4028, 4050, 4077, 4103, 4120, 4160, 4181, 4216, 4228, 4236, 4245, 4268, 4285, 4305, 4328, 4338, 4388, 4435], 'also': [53, 199, 627, 1034, 2192, 2202, 2298, 2654, 2685, 2744, 3298, 3833, 3863, 4149, 4307, 4332, 4406, 4424], 'muscle': [56, 202, 2264, 4314, 4417], 'central': [58, 204], 'nervous': [59, 205, 4281, 4413], 'system': [60, 87, 206, 233, 2500, 4282, 4414], 'cells': [61, 95, 207, 241, 329, 346, 1347, 1377, 1425, 1445, 2109, 2134, 2140, 2223, 2239, 2247, 2261, 2403, 2465, 2514, 2551, 2564, 2581, 2710, 2731, 2880, 2937, 3005, 3036, 3050, 3061, 3133, 3280, 3304, 3551, 3804, 3831, 3881, 3956, 4059, 4092, 4260, 4299, 4315, 4336, 4346], 'embryo.': [64, 210], 'At': [65, 211], 'subcellular': [67, 213, 2713, 3823], 'level,': [68, 214], 'localized': [71, 217, 2315, 3299, 4052, 4339], 'basolateral': [74, 220, 2164, 2183, 2681, 3288, 3474], 'membrane': [75, 221, 2165, 2184, 2755, 3064, 3475, 3915], 'duodenal': [78, 224, 499, 527, 2132, 2443, 2671, 3269, 3385, 3549, 3635, 3788], 'epithelial': [79, 225, 500, 528, 625, 2133, 2444, 3279, 3386, 3459, 3550, 3636], 'cell': [80, 226, 501, 519, 591, 626, 1485, 1582, 2445, 2574, 2897, 3294, 3460, 3760, 3859, 3890, 4167], 'cytoplasmic': [83, 229, 2159, 2189, 3865, 4276], 'compartment': [84, 230, 3879, 3933], 'cells.': [88, 234, 2995, 3637, 3821, 3918, 4075, 4242, 4431], 'Overexpression': [89, 235], 'tissue': [93, 239, 2037, 2050, 3131, 3855], 'culture': [94, 240, 3132, 3856], 'results': [96, 242, 2482, 2601, 2822, 3075, 3134, 4377], 'intracellular': [98, 143, 244, 289, 341, 2799, 3084, 3878, 3932, 3963, 4291], 'depletion.': [100, 246, 3465], 'In': [101, 247, 906, 2305, 2456, 2718, 3517, 3736, 3753, 3836, 4156, 4172, 4258, 4403, 4419], 'adult': [103, 249, 4311], 'mouse,': [104, 250, 1903, 1916], 'expression': [106, 119, 125, 252, 265, 271, 1408, 2114, 2278, 2313, 2337, 2461, 2471, 2477, 2486, 2499, 2588, 2652, 2948, 3092, 3235, 3270, 3337, 3496, 3546, 3761, 3775, 3892, 4182, 4212, 4217, 4246], 'liver': [109, 255, 2226, 2407, 2425, 2468, 2632, 2699, 4158, 4201], 'duodenum': [111, 122, 257, 268, 325, 2063, 2427, 2643, 2658, 3342, 3501, 3519], 'are': [112, 258, 758, 913, 1921, 1928, 1932, 3562, 3683, 4043, 4093, 4331], 'reciprocally': [113, 259, 3563], 'regulated.': [114, 260], 'Iron': [115, 261, 357, 621, 2578, 2820], 'deficiency': [116, 262, 2821], 'induces': [117, 263], 'but': [123, 269, 660, 747, 2188, 2492, 2541, 2682, 3588, 3957], 'down-regulates': [124, 270], 'liver.': [128, 274], 'These': [129, 275, 1063, 1926, 2272, 2481, 2600, 3365, 4376], 'data': [130, 276, 2273, 2279, 3366], 'indicate': [131, 277, 2281, 2602, 4378], 'an': [135, 281, 827, 1039, 1666, 1715, 1754, 1859, 2176, 2543, 2779, 2787, 2831, 3014, 3023, 3146, 3931, 4062], 'membrane-spanning': [137, 283], 'metabolism.': [145, 291, 2293, 4387, 4418], 'iron-responsive': [292, 381], 'elements': [293, 382], 'untranslated': [294, 387], 'regions': [295, 388, 1940], 'kilobase': [304], 'pair': [305], 'polymerase': [306], 'chain': [307, 4145], 'reaction': [308], 'rapid': [309], 'amplification': [310, 1189], 'cDNA': [312, 983, 986, 1057, 1081, 1094, 1138, 1148, 1191, 1223, 1783, 1796, 1833], 'ends': [313, 1052, 1192], 'endoplasmic': [314, 4055], 'reticulum': [315, 4056], 'iron-regulatory': [316, 401], 'cytomegalovirus': [318], 'The': [319, 366, 419, 816, 968, 1087, 1100, 1115, 1316, 1528, 1660, 1773, 1823, 1849, 1896, 1914, 2017, 2146, 2626, 2639, 2910, 2996, 3074, 3088, 3234, 3268, 3334, 3388, 3446, 3490, 3576, 3799, 3822, 3874, 4105, 4139, 4279, 4432], 'uptake': [320, 490], 'by': [323, 327, 335, 376, 687, 710, 862, 877, 1036, 1073, 1107, 1143, 1321, 1489, 1540, 1619, 1780, 1888, 2091, 2103, 2117, 2509, 3008, 3479, 3488, 3492, 3565, 3578, 3686, 3767, 3790], 'individual': [328], 'regulated': [334, 3564, 3581, 3766], 'total': [336, 1581, 3462], 'levels': [339, 2572, 3045, 4295], 'levels,': [343], 'respectively.': [344, 2569], 'Individual': [345], 'take': [347, 538], 'up': [348, 539], 'bound': [350, 4038], 'transferrin': [352, 355, 372, 441, 3991], 'using': [353, 932, 1176, 1196, 1369, 1428, 1456, 1498, 1523, 1534, 1665, 1680, 1727, 1753, 1782, 1795, 1941, 1966, 1971, 2002, 2046, 2437, 2905, 3013, 3022, 3167], 'receptor.': [356], 'not': [358, 676, 2079, 2111, 2136, 2761, 3072, 3525, 3586, 3684, 3719, 3848, 3872, 3883, 3899, 3903, 3947, 4088, 4199, 4207], 'immediately': [359], 'utilized': [360], 'stored': [362], 'as': [363, 435, 703, 826, 1252, 1886, 2786, 3145, 3399, 3980, 3993], 'cytosolic': [364, 397, 3086, 4293], 'ferritin.': [365, 2794], 'iron-dependent': [367, 1229, 1338, 2414, 2506, 2608, 2616, 2788, 2924], 'regulation': [368, 751, 917, 1230, 1339, 2415, 2508, 2609, 2612, 2617, 2628, 2640, 2925, 3094, 3491, 3629, 3732, 3789, 3800, 4116], 'ferritin': [370, 436, 704, 1503, 1536, 1880, 2818, 2999, 3044, 3139, 3545, 3559, 3584, 3631, 3995, 4035, 4118, 4146], 'receptor': [373, 442], 'mediated': [375, 3625], 'post-transcriptional': [378, 3626], 'interaction': [379], '(IREs),1': [383], 'found': [384, 427, 2004, 3285], '(UTRs)': [389], 'mRNAs': [392], 'these': [394, 1723, 1977, 2490, 2936, 3077, 3820, 3917, 3955, 4074, 4091, 4241, 4298, 4326], 'genes,': [395, 2792], 'with': [396, 1353, 1359, 1381, 1434, 1544, 1688, 1864, 1877, 1981, 2161, 2518, 2554, 2594, 2620, 2683, 2711, 2725, 2884, 2959, 3039, 3047, 3343, 3513, 3773, 3866, 4337], 'RNA-binding': [398], 'proteins': [399, 402, 1920, 1927], 'called': [400, 598, 632, 773], '(IRP1': [403], 'IRP2)': [405], '(1.Haile': [406, 2839], 'D.J.': [407, 1549, 2840, 2853], 'Am.': [408, 721, 2841, 3533, 3610, 4002], 'J.': [409, 647, 720, 722, 800, 963, 1555, 2842, 2859, 3191, 3195, 3218, 3417, 3534, 3611, 4001, 4003], 'Med.': [410, 2843], 'Sci.': [411, 1563, 2844, 2867, 3655], '1999;': [412, 480, 551, 652, 2845, 3359, 3422, 3600], '18:': [413, 2846], '230-240Crossref': [414, 2847], 'Scopus': [415, 467, 577, 656, 728, 743, 812, 944, 1571, 2848, 2875, 3230, 3330, 3426, 3663, 4009, 4024, 4372], '(62)': [416, 2849], 'Google': [417, 469, 484, 555, 579, 619, 658, 730, 745, 814, 946, 1573, 2850, 2877, 3232, 3332, 3363, 3428, 3539, 3604, 3616, 3665, 4011, 4026, 4374], 'Scholar).': [418, 485, 580, 620, 815, 947, 1574, 2878, 3233, 3333, 3364, 4027, 4375], 'IRE': [420, 1031, 1538, 1612, 1821, 1844, 1850, 1881, 2544, 2812, 2834, 2943, 3622, 3708, 3717, 4135], 'well': [423, 677], 'conserved': [424, 1988], 'RNA': [425, 2051], 'stem-loop': [426], '5′-UTR': [430, 957, 973, 1248, 1256, 1294, 1329, 1769, 1856, 2529, 2606, 3515], 'genes': [433, 911, 1907], 'such': [434], '3′-UTR': [439], 'dmt1': [444], '(2.Gunshin': [445, 3308, 4350], 'H.': [446, 735, 3309, 4016, 4351], 'Mackenzie': [447, 3310, 4352], 'B.': [448, 3201, 3311, 4353], 'Berger': [449, 3312, 4354], 'U.V.': [450, 3313, 4355], 'Gunshin': [451, 3314, 4356], 'Y.': [452, 3189, 3315, 4357], 'Romero': [453, 3316, 4358], 'M.F.': [454, 3317, 4359], 'Boron': [455, 3318, 4360], 'W.F.': [456, 568, 3319, 4361], 'Nussberger': [457, 3320, 4362], 'S.': [458, 474, 545, 718, 795, 1565, 2869, 3321, 3353, 3594, 3657, 3999, 4363], 'Gollan': [459, 3322, 4364], 'J.L.': [460, 3214, 3323, 4365], 'Hediger': [461, 3324, 4366], 'M.A.': [462, 562, 3325, 4367], 'Nature.': [463, 3225, 3326, 4368], '1997;': [464, 573, 803, 3327, 3536, 3613, 4369], '388:': [465, 3328, 4370], '483-487Crossref': [466, 3329, 4371], '(2721)': [468, 3331, 4373], 'Scholar,': [470, 556, 731, 2851, 3605, 4012], '3.Canonne-Hergaux': [471], 'F.': [472, 543, 3351, 3592], 'Gruenheid': [473, 544, 794, 3352, 3593], 'Ponka': [475, 546, 3354, 3595], 'P.': [476, 478, 547, 549, 737, 799, 3355, 3357, 3596, 3598, 4018], 'Gros': [477, 548, 798, 3356, 3597], 'Blood.': [479, 550, 3358, 3599], '93:': [481, 552, 3360, 3601], '4406-4417Crossref': [482, 553, 3361, 3602], 'PubMed': [483, 554, 576, 655, 727, 742, 811, 943, 1570, 2874, 3229, 3362, 3425, 3603, 3662, 4008, 4023], 'Intestinal': [486], 'acquisition': [488, 837], 'requires': [489, 628, 3442], 'at': [493, 520, 1120, 1511, 1706, 1714, 1836, 1936, 2181, 2746, 2773, 3286, 3671, 4165, 4183], 'brush': [495, 523], 'border': [496, 524], 'subsequent': [503], 'export': [504, 622, 3178, 3453, 3911, 3926, 3936, 3953, 4082, 4111, 4238], 'across': [508, 3440, 3472, 3912], 'basal': [510, 2691, 3373], 'border.': [511], 'DMT1': [512, 534, 780, 1950, 3122, 3349, 3633, 4330], '(NRAMP2,': [513], 'DCT1)': [514], 'transports': [515], 'into': [517, 1261, 1287, 1858, 3962], 'apical': [522, 2689, 3292], 'cell.': [529, 3387], 'A': [530, 995, 1158, 1254, 1272, 2081, 2169, 2326, 2497, 2737], 'mouse': [531, 981, 1147, 1160, 1170, 1185, 1204, 1220, 1234, 1242, 1647, 1774, 1786, 1807, 1854, 2041, 2065, 2121, 2151, 2178, 2301, 2670, 2698, 3099, 3449, 3857], 'mutant': [532], 'unable': [536, 3451], 'intestinal': [540, 585, 1080, 1831, 3293, 3458, 3828], '(3.Canonne-Hergaux': [542, 3350, 3591], '4.Fleming': [557], 'M.D.': [558, 3220], 'Trenor': [559], 'C.C.': [560], 'Su': [561], 'Foernzler': [563], 'D.': [564], 'Beier': [565], 'D.R.': [566], 'Dietrich': [567], 'Andrews': [569, 3221], 'N.C.': [570, 3222], 'Nat.': [571, 650, 3420], 'Genet.': [572, 651, 3421], '16:': [574], '383-386Crossref': [575], '(1033)': [578], 'An': [581, 1025], 'alternative': [582], 'pathway': [583, 4065], 'for': [584, 851, 870, 904, 927, 1413, 1605, 1655, 1722, 1882, 2901, 2915, 3107, 3175, 3380, 3909, 4039, 4227, 4319], 'absorption': [587, 4396, 4453], 'involves': [589], 'surface': [592, 3374, 3849, 4186, 4221], 'β3': [593], 'integrin,': [594], 'calreticulin-like': [596], 'molecule': [597, 829, 3109], 'mobilferrin,': [599], 'ferrireductase': [602], 'has': [603, 712, 1963, 3433, 4407], 'been': [604, 713, 1964], 'described': [605, 714], '(5.Umbreit': [606], 'J.N.': [607], 'Conrad': [608], 'M.E.': [609], 'Moore': [610], 'E.G.': [611], 'Latour': [612], 'L.F.': [613], 'Semin.': [614], 'Hematol.': [615, 723, 4004], '1998;': [616], '35:': [617], '13-26PubMed': [618], 'from': [623, 696, 838, 1042, 1075, 1112, 1167, 1179, 1217, 1276, 1330, 1484, 1579, 1785, 1798, 1842, 1852, 2149, 2175, 2428, 2987, 3260, 3383, 3583, 3679, 3698, 3751, 3927, 3954, 3974, 4083, 4240], 'copper-dependent': [630, 3431], 'ferroxidase': [631, 3444], 'hephaestin': [633, 3403], '(6.Vulpe': [634, 3404], 'C.D.': [635, 3405], 'Kuo': [636, 3406], 'Y.M.': [637, 3407], 'Murphy': [638, 3408], 'T.L.': [639, 3409], 'Cowley': [640, 3410], 'L.': [641, 938, 3224, 3411], 'Askwith': [642, 3412], 'C.': [643, 936, 3208, 3413], 'Libina': [644, 3414], 'N.': [645, 3415], 'Gitschier': [646, 3416], 'Anderson': [648, 3418], 'G.J.': [649, 3419], '21:': [653, 3423], '195-199Crossref': [654, 3424], '(938)': [657, 3427], 'Scholar),': [659, 746, 3429], 'otherwise': [661], 'little': [662], 'known': [664, 2020, 2289, 4208], 'about': [665], 'this': [666, 820, 949, 3151, 3165, 3182, 3734, 4151, 4210, 4320, 4421], 'process.': [667], 'Another': [668], 'major': [669], 'area': [670], 'metabolism': [673, 4232, 4324, 4443], 'understood': [678], 'recycling': [683, 843, 4399], 'hemoglobin-derived': [685], 'RE': [689, 3737, 4058, 4197], 'system.': [690, 3688], 'Tissue': [691, 1696], 'macrophages': [692, 711], 'ingest': [693], 'recycled': [694], 'senescent': [697], 'erythrocytes.': [698, 3752], 'Export': [699], 'heme-derived': [701], 'low': [706, 865, 3981], 'molecular': [707, 756, 3393, 3982], 'weight': [708, 3983], '(7.Custer': [715, 3996], 'G.': [716, 3997], 'Balcerzak': [717, 3998], 'Rinehart': [719, 4000], '1982;': [724, 4005], '13:': [725, 4006], '23-36Crossref': [726, 4007], '(52)': [729, 4010], '8.Sibille': [732, 4013], 'J.C.': [733, 4014], 'Kondo': [734, 4015], 'Aisen': [736, 4017], 'Hepatology.': [738, 4019], '1988;': [739, 4020], '8:': [740, 4021], '296-301Crossref': [741, 4022], '(124)': [744, 4025], 'details': [748], 'process': [754], 'mechanisms': [757], 'lacking.': [759], 'paper': [761], 'reports': [762], 'cloning': [764, 3161], 'characterization': [766, 3163], 'MTP1.': [774, 1044], 'related': [777], 'class': [781], 'transporters': [785, 2022], 'yeast': [788], 'manganese': [789], '(SMF1)': [791], '(9.Pinner': [792], 'E.': [793], 'Raymond': [796], 'M.': [797], 'Biol.': [801], 'Chem.': [802], '272:': [804], '28933-28938Abstract': [805], 'Full': [806, 808], 'Text': [807, 809], 'PDF': [810], '(111)': [813], 'unique': [817], 'characteristics': [818], 'suggest': [822, 3367], 'it': [824, 832, 4086, 4205, 4405], 'functions': [825], 'iron-exporting': [828], 'environment': [840], 'body.': [846, 4402], 'C57/BL6': [847], 'mice': [848, 858, 2432, 2449, 2474, 2661], 'were': [849, 859, 874, 887, 896, 1058, 1065, 1095, 1141, 1226, 1350, 1378, 1398, 1403, 1426, 1446, 1487, 1700, 1749, 2015, 2515, 2552, 2576, 2881, 2899, 2982, 3018, 4187], 'used': [850, 976, 1066, 1604, 1650, 2502], 'all': [852, 2966], 'vivostudies.': [854], 'Three-': [855], 'six-month-old': [857], 'made': [860, 875, 1035, 2088], 'iron-deficient': [861, 2177, 2660], 'feeding': [863], 'diet': [867, 2155], '(Harlan': [868], 'Biosciences)': [869], '4–6': [871], 'weeks.': [872], 'Mice': [873, 886], 'iron-replete': [876, 2429, 2454, 2473, 2566, 4176], 'injection': [878], 'mg': [881], 'dextran,': [884], 'intramuscularly.': [885], 'killed': [888], '1–2': [889], 'weeks': [890], 'after': [891, 1374, 1443], 'injection,': [892], 'organs': [895], 'harvested': [897], 'fixed': [899, 1705], 'formalin': [901], 'or': [902, 1355, 1387, 1430, 1693, 1733, 2007, 2430, 2533, 2557, 2567, 2887, 3476, 3992, 4127, 4292], 'frozen': [903, 1703, 2421, 2669, 2697], 'immunohistochemistry.': [905], 'order': [907, 1151, 1410, 2560, 2920, 3027, 4046, 4287], 'identify': [909], 'new': [910], 'important': [914, 4252], 'metabolism,': [920], 'library': [922, 984, 987, 1172], 'mRNA': [924], 'sequences': [925, 1064, 1980], 'enriched': [926], 'IRP1': [928, 1885, 2777, 2816, 2838, 2902, 2942, 2972, 2980, 3136], 'binding': [929, 1883, 2813, 2835, 2903, 2973, 3989], 'was': [930, 960, 975, 1017, 1033, 1105, 1165, 1194, 1249, 1259, 1285, 1319, 1521, 1532, 1603, 1616, 1649, 1662, 1678, 1725, 1738, 1778, 1793, 1812, 2087, 2115, 2127, 2191, 2201, 2235, 2297, 2314, 2338, 2355, 2418, 2501, 2653, 2732, 2743, 2760, 2770, 2913, 3006, 3153, 3764], 'constructed': [931, 1250, 1320], 'SELEX': [933], 'technology': [934], '(10.Tuerk': [935], 'Gold': [937], 'Science.': [939], '1990;': [940], '249:': [941], '505-510Crossref': [942], '(8418)': [945], 'From': [948], 'library,': [950], '200-bp': [952], 'sequence': [953, 1104, 1117, 1131, 1310, 1851, 1900, 1995], 'corresponding': [954, 1046, 1146], 'isolated.': [961], '2D.': [962], 'Haile,': [964], 'manuscript': [965, 3152], 'preparation.': [967], 'cDNA,': [970], 'containing': [971, 998, 1240, 1295, 1711, 2523, 2537, 2782], 'IRE,': [974], 'probe': [978, 1178, 1539, 1613], 'day-15.5': [980], 'embryo': [982, 1205, 2342, 2400], '(Superscript': [985], 'pSPORT2': [989, 1043, 1431], 'CMV': [990, 1432], 'vector,': [991], 'Life': [992], 'Technologies,': [993], 'Inc.).': [994], 'plasmid': [996, 1027, 1363, 2536], 'clone': [997, 1028, 1164], '2.1-kb': [1000], 'insert,': [1001], 'which': [1002, 3103, 3506, 3794], 'included': [1003], 'entire': [1005, 1070, 1313], 'coding': [1007], 'region': [1008, 1014, 2526], 'most': [1010], '5′-untranslated': [1013], 'MTP1,': [1016, 1020, 3793], '(pSPORT2': [1019, 2890], 'GenBankTM': [1021, 1121], 'accession': [1022, 1098, 1122, 1282], 'number': [1023, 1123, 1283], 'AF215637).': [1024], 'lacking': [1029, 2542], '(ΔIRE-MTP1)': [1032], 'excision': [1037], 'SmaI': [1040], 'fragment': [1041, 1274], 'ESTs': [1045, 1111], '5′': [1049, 1181], '3′': [1051], 'human': [1055, 1071, 1078, 1093, 1102, 1200, 1222, 1762, 1790, 1829, 1878, 2043, 2076, 3691], 'identified': [1059, 1965], 'GenBankTM.': [1062, 1114], 'amplify': [1068], 'PCR': [1074], 'commercially': [1076, 1682, 2047], 'obtained': [1077], 'small': [1079, 1201, 1800, 1830, 3692], '(Marathon': [1082], 'Human': [1083], 'Small': [1084], 'Intestine': [1085], 'cDNA,CLONTECH).': [1086], 'first': [1088], '1700': [1089], 'bases': [1090, 1149, 1817, 1841, 3713], 'sequenced': [1096], '(GenBankTM': [1097, 1281], 'numberAF215636).': [1099], 'remaining': [1101], 'assembled': [1106], 'overlapping': [1108], 'multiple': [1110, 2049], 'rat': [1116, 1129, 1918], 'available': [1119, 1683, 2048], 'U76714.': [1124], 'Errors': [1125], 'published': [1128, 1542], 'nucleotide': [1130], 'resulted': [1133, 2938, 4195], 'frameshifts': [1135], 'reading': [1139, 1156], 'frame': [1140], 'corrected': [1142], 'substituting': [1144], 'obtain': [1153], 'translatable': [1155], 'frame.': [1157], '13-kb': [1159], 'genomic': [1161, 1171, 1279], 'λ': [1162], 'phage': [1163], '129SvJ': [1169], '(λFIX': [1173], 'II,': [1174], 'Stratagene)': [1175], 'end': [1182], 'cDNA.': [1187], '5′-Rapid': [1188], '(RACE)': [1193], 'done': [1195, 1533, 1679, 1701, 1726], 'Marathon': [1198], 'PCR-ready': [1199], 'intestine': [1202, 1801, 3100, 3693], 'cDNAs': [1206, 1764], '(CLONTECH)': [1207], 'per': [1208], "manufacturer's": [1209], 'recommendation.': [1210], 'Five': [1211, 1480], 'clones': [1212], 'race': [1215], 'product': [1216, 3070], 'both': [1218, 1510, 2092, 2811, 3574, 4310, 4394, 4451], 'RACE': [1224], 'reactions': [1225], 'sequenced.': [1227], 'For': [1228, 1334, 1418, 1805, 3689], 'studies': [1231, 1335, 1699, 1724], '5′-UTR,': [1236, 1343], 'luciferase': [1238, 1394, 1401, 2498, 2520, 2571, 2587], 'reporter': [1239, 2521], 'promoter': [1244, 2540], '(IRE-LUC)': [1251, 2532], 'follows.': [1253], 'PCR-generated': [1255], 'cloned': [1260], 'NcoI/HindIII': [1263], 'site': [1264, 1290, 1777, 1792, 1811, 1826, 3682, 3702, 3724], 'PGL3': [1266, 1296], 'control': [1267, 1361, 2535, 2888, 3004, 3048], 'vector': [1268, 1297, 1304, 1318], '(Promega,': [1269], 'Madison,': [1270], 'WI).': [1271], '2.7-kb': [1273], '(HindIII/SmaI)': [1275], 'DNA': [1280], 'AF216834)': [1284], 'subcloned': [1286], 'BglII/SmaI': [1289], 'complete': [1299], 'IRE-LUC': [1301, 1332, 1354, 2591], 'vector.': [1302, 1333], 'contains': [1305], '3.4': [1306], 'kb': [1307], '5′-flanking': [1309, 2525], '5′-UTR.': [1315, 2512], 'ΔIRE-LUC': [1317, 1356, 2595], 'deletion': [1322], 'theBamHI/SmaI': [1324], 'segment': [1325], '50–60%': [1344, 1422], 'confluent': [1345, 1423], 'COS7': [1346, 2108, 2513, 3889], '(24-well': [1348], 'format)': [1349], 'transiently': [1351, 2516, 2882, 3037, 3058], 'transfected': [1352, 1427, 2517, 2883, 3002, 3038, 3049, 3059], 'plasmids': [1357, 2889], 'along': [1358], 'Renillaluciferase': [1362, 1407], '(Dual': [1364], 'Luciferase': [1365], 'Assay': [1366], 'Kit,': [1367], 'Promega)': [1368], 'LipofectAMINE.': [1370], 'Twenty': [1371, 1438, 2546], 'four': [1372, 1439, 2547], 'hours': [1373, 2548], 'transfection,': [1375, 1444], 'treated': [1379, 2553], 'overnight': [1380], 'either': [1382, 2555, 2565, 3979], '50': [1383, 1388, 1466, 1601], 'μm': [1384, 1389], 'hemin': [1385, 2556], '(Sigma)': [1386, 1505, 1509], 'desferrioxamine': [1390, 2558], '(Sigma).': [1391], 'Firefly': [1392], 'andRenilla': [1393], 'activities': [1395], 'lysates': [1397, 1486, 2575, 2898, 2967, 3012], 'assayed.': [1399], 'All': [1400], 'measurements': [1402], 'normalized': [1404], 'correct': [1412], 'differences': [1414, 4123, 4129, 4179], 'transfection': [1416, 2932], 'efficiency.': [1417], 'overexpression': [1420, 2104, 2805, 2917, 3082, 3127], 'studies,': [1421], 'HEK293T': [1424, 2879, 3060], 'ΔIRE-MTP1': [1429, 2886, 2911], 'vectors': [1433], 'Superfect': [1435], 'reagent': [1436], '(Qiagen).': [1437], '48': [1441, 2893], 'h': [1442, 2894], 'harvested,': [1447], 'washed': [1448], 'phosphate-buffered': [1450], 'saline,': [1451], 'detergent': [1453, 1583], 'extracts': [1454], 'prepared': [1455], '1%': [1457, 1712], 'Triton': [1458, 1589], '10': [1460, 1575, 1938], 'mm': [1461, 1467, 1470, 1474], 'Tris-': [1462], 'HCl,': [1463], 'pH': [1464, 1597], '7.4,': [1465, 1598], 'NaCl,': [1468], 'EDTA,': [1471], 'phenylmethylsulfonyl': [1475], 'fluoride': [1476], '(Triton': [1477], 'lysis': [1478, 1590], 'buffer).': [1479], 'μg': [1481, 1576], 'separated': [1488], 'SDS': [1490], 'gel': [1491, 1529, 1890], 'electrophoresis,': [1492], 'transferred': [1493], 'nitrocellulose,': [1495], 'probed': [1497], 'rabbit': [1500, 1507, 1654, 2082], 'anti-horse': [1501], 'spleen': [1502, 2074], 'antiserum': [1504, 1661], 'anti-actin': [1508, 3024], '1:1000': [1512], 'dilution,': [1513], 'horseradish': [1516], 'peroxidase-labeled': [1517], 'secondary': [1518, 2635, 2802], 'antibody.': [1519, 3016], 'Signal': [1520], 'detected': [1522, 2128], 'enhanced': [1525, 4102], 'chemiluminescence': [1526], 'kit.': [1527], 'retardation': [1530, 1891], 'assay': [1531, 1607, 1892], 'radiolabeled': [1535], 'H-chain': [1537, 1879], 'previously': [1541], 'protocols': [1543], 'following': [1546], 'modifications': [1547], '(11.Haile': [1548], 'Rouault': [1550, 2854], 'T.A.': [1551, 2855, 3641], 'Tang': [1552, 2856], 'C.K.': [1553, 2857], 'Chin': [1554, 2858], 'Harford': [1556, 2860, 3648], 'J.B.': [1557, 2861, 3649], 'Klausner': [1558, 2862, 3650], 'R.D.': [1559, 2863, 3651], 'Proc.': [1560, 2864, 3652], 'Natl.': [1561, 2865, 3653], 'Acad.': [1562, 2866, 3654], 'U.': [1564, 2868, 3656], 'A.': [1566, 2870, 3185, 3187, 3199, 3203, 3645, 3658], '1992;': [1567, 2871], '89:': [1568, 2872], '7536-7540Crossref': [1569, 2873], '(219)': [1572, 2876], 'extract': [1584], '18': [1586], 'μl': [1587], 'buffer': [1591], '(with': [1592], '5%': [1593], 'glycerol': [1594], 'Tris-HCl,': [1596], 'raised': [1599], 'mm)': [1602], 'each': [1606, 4134], 'point.': [1608], '50,000': [1609], 'cpm': [1610], '(2': [1614], 'ng)': [1615], 'added': [1617], 'followed': [1618], 'unit': [1621], 'T1': [1623], 'nuclease': [1624], 'heparin': [1626], 'final': [1629], 'concentration': [1630, 1717, 2180], '5': [1632, 2955, 3052], 'mg/ml': [1633], 'prior': [1634], 'electrophoresis.': [1636], 'Recombinant': [1637], 'peptide': [1638, 1670, 2085], 'produced': [1639, 2102], 'Escherichia': [1641], 'coli': [1642], '(amino': [1643, 1671], 'acids': [1644, 1672], '223–303': [1645], 'MTP1)': [1648], 'immunize': [1652], 'production': [1656], 'anti-MTP1': [1658, 2084, 2173, 2439], 'antiserum.': [1659], 'immunoaffinity': [1663], 'purified': [1664], 'immobilized': [1667], '28-amino': [1668], 'acid': [1669, 1899, 1979, 1994, 2000], '236–263': [1673], 'MTP1).': [1675], 'Immunohistochemical': [1676, 2435], 'staining': [1677, 2147, 2174, 2190, 2242, 2354, 2436, 2446, 2452, 2667, 2684, 2695, 2706, 2756, 2768, 3869], 'kit': [1684], '(Envision': [1685], 'Plus,': [1686], 'Dako)': [1687], 'Vector': [1689], 'VIP': [1690], '(Vector': [1691], 'Laboratories)': [1692], 'diaminobenzidine': [1694], 'substrate.': [1695], 'indirect': [1697], 'immunofluorescent': [1698, 2666], 'on': [1702, 2152, 3246, 3573, 4114, 4218], 'sections': [1704, 2422, 2672, 2700], '−20': [1707], '°C': [1708], 'acetone': [1710], 'paraformaldehyde': [1713], 'antibody': [1716, 1737, 1744, 2086, 2440, 2775, 3025], '12.5': [1719], 'μg/ml.': [1720], 'Blocking': [1721], '10%': [1728, 1731], 'milk': [1729], 'horse': [1732], 'goat': [1734, 1741], 'serum.': [1735], 'Secondary': [1736], 'Alexa': [1739], '488-conjugated': [1740], 'anti-rabbit': [1742], 'IgG': [1743], '(Molecular': [1745], 'Probes).': [1746], 'Fluorescent': [1747], 'images': [1748], 'viewed': [1750], 'photographed': [1752], 'Olympus': [1755], 'BX-40': [1756], 'fluorescent': [1757], 'microscope.': [1758], 'Mouse,': [1759], 'rat,': [1760], 'contain': [1765, 1935], 'IREs': [1766, 3670], '(Fig.': [1770, 1802, 1846, 1872, 1893, 1911, 1996, 2141, 2194, 2214, 2227, 2251, 2265, 2343, 2369, 2382, 2388, 2597, 2662, 2701, 2954, 3051], 'a).': [1772, 1804, 1848, 2124, 2434, 2664, 2956], 'transcription': [1775, 1824, 3700], 'start': [1776, 1791, 1810, 1825, 3701, 3723], 'determined': [1779, 1794, 1813, 3668], '5′-RACE': [1781], 'derived': [1784, 1797], 'embryo,': [1787, 1808, 4267], 'be': [1815, 2634, 2807, 3105, 3257, 3508, 3720, 3817, 4163, 4251, 4391], '53': [1816], 'proximal': [1818, 2245, 4344], 'stem.': [1822], 'placed': [1835], 'distance': [1838, 3673, 3697], '73': [1840], 'stem': [1845, 1862], 'folds': [1857], 'appropriate': [1860], 'IRE-like': [1861], 'loop': [1863], 'calculated': [1866], 'free': [1867], 'energy': [1868], '−15.2': [1870], 'kcal/mol': [1871], 'b)': [1874, 2703], 'competes': [1876], 'demonstrated': [1887, 2053, 2156, 2179, 2441, 2673, 2704, 3062, 3887, 3971], 'c).': [1895], 'deduced': [1897], 'amino': [1898, 1978, 1989, 1993], 'human,': [1904, 1915], 'ratmtp1': [1906], 'illustrated': [1909], 'below': [1910], 'd).': [1913, 1998], 'greater': [1922, 3675], 'than': [1923, 3676, 3711], '90%': [1924], 'similar.': [1925], '62': [1929], 'kilodaltons': [1930], 'predicted': [1933, 3106], 'least': [1937], 'transmembrane': [1939], 'TMHMM': [1943, 1973], 'algorithm.': [1944, 1974], 'Homology': [1945], 'family,': [1951, 1954], 'SMF1': [1953], 'two': [1956], 'uncharacterized': [1957], 'products': [1959], '(AAC28758': [1960], 'AAB94213)': [1962], 'PROPSEARCH': [1967], 'Blast': [1969], 'algorithms': [1970], 'Alignment': [1975], 'MTP1s': [1983], 'demonstrates': [1984], 'similarity': [1985], '(identical': [1986], 'acids)': [1990], 'throughout': [1991, 2340, 2687], 'Amino': [1999], 'analysis': [2001, 2034], 'PROSITE': [2003], 'no': [2005, 2162, 3867, 4178], 'signal': [2006], 'localization': [2008, 3065], 'sequences.': [2009], 'Several': [2010], 'N-': [2011], 'andO-linked': [2012], 'glycosylation': [2013], 'sites': [2014], 'identified.': [2016], 'homology': [2018], 'supports': [2023], 'hypothesis': [2025], 'transporter.': [2031], 'Northern': [2032, 2276], 'blot': [2033, 2094, 2277], 'distribution': [2038, 2160, 2675, 2714, 3824, 3846, 3897], 'mRNA,': [2045, 3695], 'blots,': [2052], 'highest': [2054], 'abundance': [2055, 2067], 'spleen,': [2058], 'liver,': [2059], 'kidney,': [2060], 'heart,': [2061], 'placenta,': [2070], 'intestine,': [2071], 'muscle,': [2072], 'blots': [2077], '(data': [2078, 2110, 3071, 3524, 3871, 3898], 'shown).': [2080, 2112, 3073, 3873, 3900], 'polyclonal': [2083], 'confirmed': [2090], 'Western': [2093, 3009], 'immunohistochemistry': [2096, 2118], 'recognize': [2098], 'specifically': [2099], 'NIH3T3': [2106], 'assayed': [2116], 'several': [2120], '(Fig.2': [2123, 2166, 2303, 2323, 2360, 2408], 'immunostaining': [2126, 2724, 2742], 'crypt': [2139], '2': [2142, 2195, 2215, 2228, 2252, 2266, 2344, 2370, 2383, 2389], 'a,': [2143, 2167, 2196, 2229, 2253, 2267], 'panels': [2144, 2168, 2197, 2230, 2254, 2268, 2325, 2346, 2362, 2372, 2391, 2736], 'A–D).': [2145], 'pattern': [2148, 2459, 3090], 'normal': [2154], 'predominantly': [2158, 2716, 3842, 3864], 'discernible': [2163], 'B).': [2171, 2328], 'Duodenal': [2172], 'cells,': [2187, 2720, 3738, 3838, 4085], 'evident': [2193, 2203, 2771], 'C': [2198, 2347], 'andD).': [2199], 'Immunostaining': [2200], 'splenic': [2206], 'macrophage': [2207], 'megakaryocytes': [2209], 'red': [2212], 'pulp': [2213], 'a,panels': [2216], 'E': [2217, 2363], 'F)': [2219], 'Kupffer': [2222, 2402, 2464, 2709, 2730, 3759, 3803, 3830, 3837, 4084], 'G': [2231], 'H).': [2233], 'Expression': [2234, 2294], 'noted': [2236, 2339, 2733, 2745, 2762, 3870], 'glomerular': [2238], 'weaker': [2241, 2451], 'tubular': [2246, 4345], 'kidney': [2250, 4335, 4349, 4384], 'I': [2255], 'J)': [2257], 'spindle-shaped': [2260], 'heart': [2263, 2381], 'K': [2269], 'L).': [2271], 'support': [2274], 'importance': [2290], 'examined': [2299, 2419, 2655, 2900], 'embryos': [2302], 'b).': [2304, 2599, 3053], 'early': [2306], 'embryogenesis': [2307], '(days': [2308, 2332], '8': [2309], '10),': [2311], 'decidua': [2318, 3240], 'uterus': [2322, 3244], 'b,': [2324, 2345, 2361, 2371, 2384, 2390, 2409, 2735], 'Later': [2329], 'development': [2331], '14': [2333], '16),': [2335], 'D).': [2349], 'Notably,': [2350], 'later': [2352], 'embryos,': [2353], 'present': [2356, 2686], 'brain': [2359], 'K)': [2365], 'spinal': [2367], 'cord': [2368], 'F': [2373], 'L),': [2375], 'myocytes': [2376], 'vessels': [2379], 'panel': [2385, 2410], 'G),': [2386], 'tongue': [2387], 'H': [2392], 'J),': [2394], 'other': [2396, 2647, 3156, 3477, 3589, 4256, 4259], 'muscles': [2397], 'embryonic': [2406, 4313], 'I).': [2411], 'Total': [2412], 'iron-deprived': [2431, 2448, 2479, 4174], '(Fig.3': [2433], 'strong': [2442, 2470], 'mice.': [2455, 2480], 'contrast,': [2457], 'showed': [2469], 'less': [2476], 'demonstrate': [2483, 3079], 'reciprocal': [2495], 'manner.': [2496], 'directly': [2504], 'confirm': [2505, 3029], 'translational': [2507], '3.4-kb': [2524], 'same': [2539], '(ΔIRE-LUC).': [2545], 'later,': [2549, 2895], 'make': [2562], 'iron-deficient,': [2568], 'Subsequently,': [2570], 'measured.': [2577], 'starvation': [2579], 'led': [2582], 'decrease': [2585], 'transfectants': [2592, 2596], 'compared': [2593, 3046], '3': [2598], 'confers': [2607], 'similar': [2613, 2969], 'ferritin,': [2619, 3808], 'deprivation': [2622, 3345], 'inhibiting': [2623, 3779], 'expression.': [2625, 2819, 3781], 'observed': [2629, 2977, 3542, 3801], 'may': [2633, 2644, 3256, 3718, 3726, 3816, 3946, 3958, 4029, 4066, 4112, 4148, 4237, 4249, 4269, 4283], 'IRE.': [2638, 3516], 'depend': [2645, 4113], 'upon': [2646], 'mechanisms.': [2648], 'Localization': [2649], '4': [2663, 2702], 'Indirect': [2665, 2693, 3054], 'prominently': [2680], 'cytoplasm.': [2692], 'immunofluorescence': [2694, 3055], 'abundant': [2705], 'being': [2715], 'cytoplasmic.': [2717], 'many': [2719], 'co-localization': [2721], 'hemosiderin': [2726], 'granules': [2727], '(Fig.4': [2734], 'C).': [2739], 'Specific': [2740], 'sinusoidal': [2748, 4185, 4220], 'borders': [2749], 'hepatocytes.': [2752], 'plasma': [2754, 3063, 3914], 'hepatocytes': [2759, 4223, 4248], 'previous': [2765], 'paraffin-embedded': [2766], 'section': [2767], 'only': [2772, 4194], 'higher': [2774], 'concentrations.': [2776], 'iron-sulfur': [2780, 2964], 'cluster': [2781], 'serves': [2785], 'regulator': [2789], 'IRE-containing': [2791], 'Therefore,': [2795, 3555, 4204], 'perturbation': [2797], 'content': [2801], 'would': [2806, 3104, 3507], 'expected': [2808, 3035, 3089, 3509], 'alter': [2810, 4150], 'activity': [2814, 2836, 2904, 2981], 'conversion': [2824], 'holoIRP1': [2826, 2989], 'apoIRP1': [2828, 2991], 'resulting': [2829], 'increase': [2832], '11.Haile': [2852], 'CMV),': [2891], 'detergent-extracted': [2896], 'electrophoretic': [2906], 'mobility': [2907], 'shift': [2908, 2986], 'assay.': [2909], 'construct': [2912], 'chosen': [2914], 'experiments': [2918, 3078, 4042], 'abolish': [2922], 'potential': [2923], 'ofmtp1': [2926], 'itself.': [2928], 'As': [2929, 3034], 'expected,': [2930], 'transient': [2931], 'activation': [2940, 3137], 'binding,': [2944], 'indicating': [2945, 3141, 3253, 4316], 'leads': [2949], 'intracellular/cytosolic': [2951], 'depletion': [2953, 3140], 'On': [2957], 'treatment': [2958], 'ferricyanide': [2960], '(which': [2961], 'destroys': [2962], 'cluster),': [2965], 'had': [2968, 3041], 'amounts': [2970], 'activity.': [2974, 3445, 4104], 'Thus,': [2975], 'changes': [2978], 'due': [2983, 4121], 'MTP1-transfected': [2994], 'amount': [2997], 'assessed': [3007], 'blotting': [3010], 'anti-ferritin': [3015], 'Blots': [3017], 'stripped': [3019], 're-probed': [3021], 'equal': [3030], 'loading': [3031], 'lanes.': [3033], 'diminished': [3042], 'cellular': [3043], 'examination': [3056], 'depletes': [3083], 'iron.': [3087], 'acquisition.': [3113], 'member': [3116], '(NRAMP)': [3123], 'transporters,': [3125], 'possible': [3143, 3468, 4380], 'role': [3144, 3729, 3950, 4069, 4226, 4318, 4381, 4409, 4440], 'exporter.': [3148], 'Furthermore,': [3149, 4304], 'while': [3150], 'review,': [3155], 'investigators': [3157, 3639], 'reported': [3159], 'zebrafish': [3169], 'anemia': [3170, 3398, 3448], 'model': [3171], 'provided': [3173, 3434], 'evidence': [3174, 3435], 'MTP1-mediated': [3176], 'Xenopusoocytes': [3180], 'overexpressing': [3181], '(12.Donovan': [3184], 'Brownliet': [3186], 'Zhou': [3188], 'Shepard': [3190], 'Praw': [3192], 'S.J.': [3193], 'Moynihan': [3194], 'Paw': [3196], 'B.H.': [3197], 'Drejer': [3198], 'Barut': [3200], 'Zapata': [3202], 'Law': [3204], 'T.C.,': [3205], 'II': [3206], 'Brugnarall': [3207], 'Lux': [3209], 'S.E.': [3210], 'Pinkusl': [3211], 'G.S.': [3212], 'Pinkusi': [3213], 'Kingsley': [3215], 'P.D.': [3216], 'Palis': [3217], 'Fleming': [3219], 'Zon': [3223], '2000;': [3226], '403:': [3227], '776-780Crossref': [3228], '(1397)': [3231], 'maternal': [3248, 3262], 'side': [3249, 3263], 'circulation': [3252], 'exporting': [3258, 3381], 'fetal': [3266], 'circulation.': [3267], 'limited': [3274], 'absorptive': [3278, 3303], 'villus': [3283, 3307], 'membrane.': [3289], 'DMT1,': [3290], 'transporter,': [3296], 'up-regulation': [3335, 3543], 'parallels': [3346, 3805], 'likely': [3371, 3621, 3741, 3904], 'responsible': [3379, 3908], 'recent': [3389], 'elucidation': [3390, 4437], 'defect': [3394], 'sex-linked': [3397, 3447], 'mutation': [3401], 'ferroxidase,': [3432], 'ferrous': [3437], 'transport': [3439, 3471], 'membranes': [3441, 3478], 'out': [3455], 'despite': [3461, 3567], 'It': [3466, 3901], 'coupled': [3482], 'oxidation': [3484], 'hephaestin.': [3489], 'opposite': [3504, 3797], 'iron-treated': [3521], 'rodents,': [3522], 'we': [3523], 'shown)': [3526], 'others': [3528], '(13.Oates': [3529], 'P.S.': [3530, 3607], 'Morgan': [3531, 3608], 'E.H.': [3532, 3609], 'Physiol.': [3535, 3612], '273:': [3537, 3614], 'G636-G646PubMed': [3538, 3615], 'Scholar)': [3540, 3617, 3666], 'villus.': [3554], 'presence': [3569, 4100], '5′-IRE': [3572, 3815], 'genes.': [3575], 'mechanism': [3577], 'whichMTP1': [3579], 'oppositely': [3582], 'known,': [3587], 'authors': [3590], '13.Oates': [3606], 'pointed': [3619], 'non-IRE': [3624], 'transcriptional': [3628, 4125], 'Other': [3638], '(14.Rouault': [3640], 'Hentze': [3642], 'M.W.': [3643], 'Dancis': [3644], 'Caughman': [3646], 'W.': [3647], '1987;': [3659], '84:': [3660], '6335-6339Crossref': [3661], '(44)': [3664], '67': [3677, 3712], 'nucleotides': [3678], 'cap': [3681], 'repressible': [3685], 'IRE/IRP1': [3687], 'base': [3705], 'longer': [3710], 'suggesting': [3714, 3812], 'functional.': [3721], 'Transcription': [3722], 'selection': [3725], 'play': [3727, 4067], 'gene.': [3735], 'reutilization/storage': [3745], 'scavenged': [3750], 'our': [3754, 4173], 'dextran-injected': [3756], 'animals,': [3757], 'clearly': [3765], 'ferritin-like': [3771], 'manner': [3772], 'iron-inducing': [3774], 'derivation': [3778], 'contrast': [3785], 'pattern.': [3798], 'another': [3809], '5′-IRE-containing': [3810], 'functional': [3818], 'distinctly': [3834], 'different.': [3835], 'cytoplasmic/intracellular': [3845], 'membrane-localized.': [3850], 'Additionally,': [3851], 'monocyte': [3858], 'line,': [3860], 'RAW267.4,': [3861], 'membrane-localized': [3868], 'identity': [3875], 'known.': [3884], 'Experiments': [3885], 'primarily': [3894], 'ER': [3895], 'More': [3919], 'likely,': [3920], 'cytosol': [3929], 'possibly': [3935, 4250], 'through': [3940], 'secretory': [3942, 4064], 'pathway.': [3943], 'Alternatively,': [3944], 'simply': [3959], 'move': [3960], 'compartments.': [3964], 'Most': [3965], 'experimental': [3966], 'models': [3967], 'erythophagocytosis': [3969], 'hemoglobin': [3975], 'degradation': [3976], 'released': [3978], 'capable': [3987], 'secreted': [3994], 'supply': [4030], 'ER-synthesized': [4034], 'export.': [4040], 'Further': [4041], 'needed': [4044], 'determine': [4048], 'if': [4049, 4061], 'ER-mediated': [4063], 'export/storage': [4072], 'If': [4076], 'clear': [4089], 'how': [4090], 'able': [4094], 'store': [4096], 'balance': [4106, 4152], 'between': [4107], 'storage': [4109], 'differential': [4115], 'rates': [4126], 'affinity': [4132], 'IRPs.': [4138], 'ratio': [4140], 'heavy': [4142], 'light': [4144], 'subunits': [4147], 'particular': [4154], 'tissues.': [4155, 4327], 'hepatocytes,': [4159], 'appears': [4161, 4389], 'surfaces': [4168], 'lining': [4169], 'sinusoids.': [4171], 'mice,': [4177], 'noted,': [4188], 'although': [4189], 'dextran': [4192], 'injections': [4193], 'parenchymal': [4200], 'loads.': [4203], 'whether': [4209], 'hepatocyte': [4211, 4214, 4230], 'iron-regulated.': [4215], 'suggests': [4224, 4234], 'Dysregulation': [4243], 'hemochromatosis': [4254], 'conditions.': [4257], 'body,': [4263], 'especially': [4264], 'protective': [4272], 'function': [4273], 'limiting': [4275], 'levels.': [4278], 'require': [4284], 'tightly': [4289], 'regulate': [4290], 'protect': [4297], 'against': [4300], 'iron-mediated': [4301], 'oxidative': [4302], 'injury.': [4303], 'glomerulus': [4342], 'around': [4400], 'addition,': [4404, 4420], 'variety': [4428], 'tumor': [4430], 'identification': [4433], 'its': [4439], 'will': [4444], 'lead': [4445], 'better': [4448], 'understanding': [4449], 'recycling.': [4455]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2063617352', 'counts_by_year': [{'year': 2024, 'cited_by_count': 25}, {'year': 2023, 'cited_by_count': 26}, {'year': 2022, 'cited_by_count': 34}, {'year': 2021, 'cited_by_count': 46}, {'year': 2020, 'cited_by_count': 51}, {'year': 2019, 'cited_by_count': 25}, {'year': 2018, 'cited_by_count': 47}, {'year': 2017, 'cited_by_count': 35}, {'year': 2016, 'cited_by_count': 51}, {'year': 2015, 'cited_by_count': 37}, {'year': 2014, 'cited_by_count': 67}, {'year': 2013, 'cited_by_count': 53}, {'year': 2012, 'cited_by_count': 50}], 'updated_date': '2025-01-07T12:15:22.575688', 'created_date': '2016-06-24'}