Title: Striatal G-proteins: Effects of unilateral 6-hydroxydopamine lesions
Abstract: To investigate the molecular mechanisms of denervation-induced dopamine receptor supersensitivity, levels of striatal G-proteins were examined in 6-hydroxydopamine (6-OHDA)-lesioned rats. Increased levels of the α-subunits of Gs and Golf, as measured by immunoblotting, were observed 8 days postlesion and remained elevated up to day 28 (25–45% over the time course). Gi levels were significantly increased only on day 8 (20%) and Go levels remained unaltered. These results suggest that stimulatory G-proteins may be involved in the long-term maintenance of dopamine receptor supersensitivity following denervation.
Publication Year: 1994
Publication Date: 1994-03-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 40
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