Publication Information

{'id': 'https://openalex.org/W2063455907', 'doi': 'https://doi.org/10.1002/ajmg.b.31030', 'title': 'Association between methylenetetrahydrofolate reductase (<i>MTHFR</i>) C677T polymorphism and age of onset in schizophrenia', 'display_name': 'Association between methylenetetrahydrofolate reductase (<i>MTHFR</i>) C677T polymorphism and age of onset in schizophrenia', 'publication_year': 2009, 'publication_date': '2009-09-10', 'ids': {'openalex': 'https://openalex.org/W2063455907', 'doi': 'https://doi.org/10.1002/ajmg.b.31030', 'mag': '2063455907', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19746410'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/ajmg.b.31030', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764647521', 'display_name': 'American Journal of Medical Genetics Part B Neuropsychiatric Genetics', 'issn_l': '1552-4841', 'issn': ['1552-4841', '1552-485X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5032944933', 'display_name': 'María Vares', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Maria Vares', 'raw_affiliation_strings': ['Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081241620', 'display_name': 'Peter Saetre', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Peter Saetre', 'raw_affiliation_strings': ['Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021925284', 'display_name': 'Hong Deng', 'orcid': 'https://orcid.org/0000-0001-8625-5554'}, 'institutions': [{'id': 'https://openalex.org/I4210089761', 'display_name': 'West China Hospital of Sichuan University', 'ror': 'https://ror.org/007mrxy13', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210089761']}, {'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hong Deng', 'raw_affiliation_strings': ['Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China'], 'affiliations': [{'raw_affiliation_string': 'Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China', 'institution_ids': ['https://openalex.org/I4210089761', 'https://openalex.org/I24185976']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111777445', 'display_name': 'Guiqing Cai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98704320', 'display_name': 'Icahn School of Medicine at Mount Sinai', 'ror': 'https://ror.org/04a9tmd77', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1320796813', 'https://openalex.org/I98704320']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Guiqing Cai', 'raw_affiliation_strings': ['Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, New York, New York'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, New York, New York', 'institution_ids': ['https://openalex.org/I98704320']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075051412', 'display_name': 'Xiehe Liu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}, {'id': 'https://openalex.org/I4210089761', 'display_name': 'West China Hospital of Sichuan University', 'ror': 'https://ror.org/007mrxy13', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210089761']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiehe Liu', 'raw_affiliation_strings': ['Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China'], 'affiliations': [{'raw_affiliation_string': 'Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China', 'institution_ids': ['https://openalex.org/I24185976', 'https://openalex.org/I4210089761']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007978629', 'display_name': 'Thomas Hansen', 'orcid': 'https://orcid.org/0000-0001-6703-7762'}, 'institutions': [{'id': 'https://openalex.org/I2800523110', 'display_name': 'Sankt Hans Hospital', 'ror': 'https://ror.org/04d9g9604', 'country_code': 'DK', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800523110', 'https://openalex.org/I2800875313', 'https://openalex.org/I2802567020', 'https://openalex.org/I4210145385']}, {'id': 'https://openalex.org/I2802567020', 'display_name': 'Copenhagen University Hospital', 'ror': 'https://ror.org/05bpbnx46', 'country_code': 'DK', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802567020']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Thomas Hansen', 'raw_affiliation_strings': ['Research Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Copenhagen University Hospital, Roskilde, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Research Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Copenhagen University Hospital, Roskilde, Denmark', 'institution_ids': ['https://openalex.org/I2800523110', 'https://openalex.org/I2802567020']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015299495', 'display_name': 'Henrik Berg Rasmussen', 'orcid': 'https://orcid.org/0000-0001-9979-7627'}, 'institutions': [{'id': 'https://openalex.org/I2802567020', 'display_name': 'Copenhagen University Hospital', 'ror': 'https://ror.org/05bpbnx46', 'country_code': 'DK', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802567020']}, {'id': 'https://openalex.org/I2800523110', 'display_name': 'Sankt Hans Hospital', 'ror': 'https://ror.org/04d9g9604', 'country_code': 'DK', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800523110', 'https://openalex.org/I2800875313', 'https://openalex.org/I2802567020', 'https://openalex.org/I4210145385']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Henrik B. Rasmussen', 'raw_affiliation_strings': ['Research Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Copenhagen University Hospital, Roskilde, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Research Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Copenhagen University Hospital, Roskilde, Denmark', 'institution_ids': ['https://openalex.org/I2802567020', 'https://openalex.org/I2800523110']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051228367', 'display_name': 'Thomas Werge', 'orcid': 'https://orcid.org/0000-0003-1829-0766'}, 'institutions': [{'id': 'https://openalex.org/I2800523110', 'display_name': 'Sankt Hans Hospital', 'ror': 'https://ror.org/04d9g9604', 'country_code': 'DK', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800523110', 'https://openalex.org/I2800875313', 'https://openalex.org/I2802567020', 'https://openalex.org/I4210145385']}, {'id': 'https://openalex.org/I2802567020', 'display_name': 'Copenhagen University Hospital', 'ror': 'https://ror.org/05bpbnx46', 'country_code': 'DK', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802567020']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Thomas Werge', 'raw_affiliation_strings': ['Research Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Copenhagen University Hospital, Roskilde, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Research Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Copenhagen University Hospital, Roskilde, Denmark', 'institution_ids': ['https://openalex.org/I2800523110', 'https://openalex.org/I2802567020']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038692125', 'display_name': 'Ingrid Melle', 'orcid': 'https://orcid.org/0000-0002-9783-548X'}, 'institutions': [{'id': 'https://openalex.org/I1281400175', 'display_name': 'Oslo University Hospital', 'ror': 'https://ror.org/00j9c2840', 'country_code': 'NO', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1281400175']}, {'id': 'https://openalex.org/I184942183', 'display_name': 'University of Oslo', 'ror': 'https://ror.org/01xtthb56', 'country_code': 'NO', 'type': 'education', 'lineage': ['https://openalex.org/I184942183']}], 'countries': ['NO'], 'is_corresponding': False, 'raw_author_name': 'Ingrid Melle', 'raw_affiliation_strings': ['Department Psychiatry, Oslo University Hospital, Ullevål, Oslo, Norway', 'Institute of Psychiatry, University of Oslo, Oslo, Norway'], 'affiliations': [{'raw_affiliation_string': 'Department Psychiatry, Oslo University Hospital, Ullevål, Oslo, Norway', 'institution_ids': ['https://openalex.org/I1281400175']}, {'raw_affiliation_string': 'Institute of Psychiatry, University of Oslo, Oslo, Norway', 'institution_ids': ['https://openalex.org/I184942183']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052826567', 'display_name': 'Srdjan Djurovic', 'orcid': 'https://orcid.org/0000-0002-8140-8061'}, 'institutions': [{'id': 'https://openalex.org/I1281400175', 'display_name': 'Oslo University Hospital', 'ror': 'https://ror.org/00j9c2840', 'country_code': 'NO', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1281400175']}, {'id': 'https://openalex.org/I184942183', 'display_name': 'University of Oslo', 'ror': 'https://ror.org/01xtthb56', 'country_code': 'NO', 'type': 'education', 'lineage': ['https://openalex.org/I184942183']}], 'countries': ['NO'], 'is_corresponding': False, 'raw_author_name': 'Srdjan Djurovic', 'raw_affiliation_strings': ['Department of Medical Genetics, Oslo University Hospital, Ullevål, Oslo, Norway', 'Institute of Psychiatry, University of Oslo, Oslo, Norway'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Genetics, Oslo University Hospital, Ullevål, Oslo, Norway', 'institution_ids': ['https://openalex.org/I1281400175']}, {'raw_affiliation_string': 'Institute of Psychiatry, University of Oslo, Oslo, Norway', 'institution_ids': ['https://openalex.org/I184942183']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020215901', 'display_name': 'Ole A. Andreassen', 'orcid': 'https://orcid.org/0000-0002-4461-3568'}, 'institutions': [{'id': 'https://openalex.org/I1281400175', 'display_name': 'Oslo University Hospital', 'ror': 'https://ror.org/00j9c2840', 'country_code': 'NO', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1281400175']}, {'id': 'https://openalex.org/I184942183', 'display_name': 'University of Oslo', 'ror': 'https://ror.org/01xtthb56', 'country_code': 'NO', 'type': 'education', 'lineage': ['https://openalex.org/I184942183']}], 'countries': ['NO'], 'is_corresponding': False, 'raw_author_name': 'Ole A. Andreassen', 'raw_affiliation_strings': ['Department Psychiatry, Oslo University Hospital, Ullevål, Oslo, Norway', 'Institute of Psychiatry, University of Oslo, Oslo, Norway'], 'affiliations': [{'raw_affiliation_string': 'Department Psychiatry, Oslo University Hospital, Ullevål, Oslo, Norway', 'institution_ids': ['https://openalex.org/I1281400175']}, {'raw_affiliation_string': 'Institute of Psychiatry, University of Oslo, Oslo, Norway', 'institution_ids': ['https://openalex.org/I184942183']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016103514', 'display_name': 'Ingrid Agartz', 'orcid': 'https://orcid.org/0000-0002-9839-5391'}, 'institutions': [{'id': 'https://openalex.org/I184942183', 'display_name': 'University of Oslo', 'ror': 'https://ror.org/01xtthb56', 'country_code': 'NO', 'type': 'education', 'lineage': ['https://openalex.org/I184942183']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['NO', 'SE'], 'is_corresponding': False, 'raw_author_name': 'Ingrid Agartz', 'raw_affiliation_strings': ['Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, Stockholm, Sweden', 'Department of Psychiatry, Section Vinderen, University of Oslo, Oslo, Norway', 'Institute of Psychiatry, University of Oslo, Oslo, Norway'], 'affiliations': [{'raw_affiliation_string': 'Department of Psychiatry, Section Vinderen, University of Oslo, Oslo, Norway', 'institution_ids': ['https://openalex.org/I184942183']}, {'raw_affiliation_string': 'Institute of Psychiatry, University of Oslo, Oslo, Norway', 'institution_ids': ['https://openalex.org/I184942183']}, {'raw_affiliation_string': 'Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108372523', 'display_name': 'Håkan Hall', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I123387679', 'display_name': 'Uppsala University', 'ror': 'https://ror.org/048a87296', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I123387679']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Håkan Hall', 'raw_affiliation_strings': ['Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, Stockholm, Sweden', 'Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden', 'institution_ids': ['https://openalex.org/I123387679']}, {'raw_affiliation_string': 'Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059913654', 'display_name': 'Lars Terenius', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Lars Terenius', 'raw_affiliation_strings': ['Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5008607142', 'display_name': 'Erik G. Jönsson', 'orcid': 'https://orcid.org/0000-0001-8368-6332'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': True, 'raw_author_name': 'Erik G. Jönsson', 'raw_affiliation_strings': ['Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}], 'institution_assertions': [], 'countries_distinct_count': 5, 'institutions_distinct_count': 9, 'corresponding_author_ids': ['https://openalex.org/A5008607142'], 'corresponding_institution_ids': ['https://openalex.org/I28166907'], 'apc_list': {'value': 4330, 'currency': 'USD', 'value_usd': 4330, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.421, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 38, 'citation_normalized_percentile': {'value': 0.847615, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '153B', 'issue': '2', 'first_page': '610', 'last_page': '618'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10499', 'display_name': 'Folate and B Vitamins Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10499', 'display_name': 'Folate and B Vitamins Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11658', 'display_name': 'Esophageal and GI Pathology', 'score': 0.9695, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12823', 'display_name': 'Adolescent and Pediatric Healthcare', 'score': 0.9322, 'subfield': {'id': 'https://openalex.org/subfields/3616', 'display_name': 'Speech and Hearing'}, 'field': {'id': 'https://openalex.org/fields/36', 'display_name': 'Health Professions'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/snp', 'display_name': 'SNP', 'score': 0.530112}], 'concepts': [{'id': 'https://openalex.org/C43563269', 'wikidata': 'https://www.wikidata.org/wiki/Q424709', 'display_name': 'Methylenetetrahydrofolate reductase', 'level': 4, 'score': 0.983096}, {'id': 'https://openalex.org/C180754005', 'wikidata': 'https://www.wikidata.org/wiki/Q80726', 'display_name': 'Allele', 'level': 3, 'score': 0.61065775}, {'id': 'https://openalex.org/C153209595', 'wikidata': 'https://www.wikidata.org/wiki/Q501128', 'display_name': 'Single-nucleotide polymorphism', 'level': 4, 'score': 0.59754455}, {'id': 'https://openalex.org/C139275648', 'wikidata': 'https://www.wikidata.org/wiki/Q17134011', 'display_name': 'SNP', 'level': 5, 'score': 0.530112}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.50735706}, {'id': 'https://openalex.org/C2780325297', 'wikidata': 'https://www.wikidata.org/wiki/Q834047', 'display_name': 'Schizoaffective disorder', 'level': 3, 'score': 0.49094513}, {'id': 'https://openalex.org/C2777767895', 'wikidata': 'https://www.wikidata.org/wiki/Q4691924', 'display_name': 'Age of onset', 'level': 3, 'score': 0.489804}, {'id': 'https://openalex.org/C2776412080', 'wikidata': 'https://www.wikidata.org/wiki/Q7431605', 'display_name': 'Schizophrenia (object-oriented programming)', 'level': 2, 'score': 0.45691165}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.45058674}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.37904072}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.3256234}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.31656218}, {'id': 'https://openalex.org/C135763542', 'wikidata': 'https://www.wikidata.org/wiki/Q106016', 'display_name': 'Genotype', 'level': 3, 'score': 0.28786245}, {'id': 'https://openalex.org/C2779727114', 'wikidata': 'https://www.wikidata.org/wiki/Q170082', 'display_name': 'Psychosis', 'level': 2, 'score': 0.28299683}, {'id': 'https://openalex.org/C118552586', 'wikidata': 'https://www.wikidata.org/wiki/Q7867', 'display_name': 'Psychiatry', 'level': 1, 'score': 0.21059012}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.15158969}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D042965', 'descriptor_name': 'Methylenetetrahydrofolate Reductase (NADPH2)', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D020641', 'descriptor_name': 'Polymorphism, Single Nucleotide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D012559', 'descriptor_name': 'Schizophrenia', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017668', 'descriptor_name': 'Age of Onset', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000483', 'descriptor_name': 'Alleles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016022', 'descriptor_name': 'Case-Control Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002681', 'descriptor_name': 'China', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005192', 'descriptor_name': 'Family Health', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042965', 'descriptor_name': 'Methylenetetrahydrofolate Reductase (NADPH2)', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012307', 'descriptor_name': 'Risk Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012537', 'descriptor_name': 'Scandinavian and Nordic Countries', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012559', 'descriptor_name': 'Schizophrenia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012559', 'descriptor_name': 'Schizophrenia', 'qualifier_ui': 'Q000453', 'qualifier_name': 'epidemiology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/ajmg.b.31030', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764647521', 'display_name': 'American Journal of Medical Genetics Part B Neuropsychiatric Genetics', 'issn_l': '1552-4841', 'issn': ['1552-4841', '1552-485X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19746410', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320320943', 'funder_display_name': 'Danmarks Grundforskningsfond', 'award_id': None}, {'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '30670757'}, {'funder': 'https://openalex.org/F4320322581', 'funder_display_name': 'Vetenskapsrådet', 'award_id': '2006-2992'}, {'funder': 'https://openalex.org/F4320322581', 'funder_display_name': 'Vetenskapsrådet', 'award_id': '2008-2167'}, {'funder': 'https://openalex.org/F4320322581', 'funder_display_name': 'Vetenskapsrådet', 'award_id': '2006-986'}, {'funder': 'https://openalex.org/F4320323299', 'funder_display_name': 'Norges Forskningsråd', 'award_id': '147787'}, {'funder': 'https://openalex.org/F4320323299', 'funder_display_name': 'Norges Forskningsråd', 'award_id': '167153'}], 'datasets': [], 'versions': [], 'referenced_works_count': 66, 'referenced_works': ['https://openalex.org/W11911259', 'https://openalex.org/W1532639927', 'https://openalex.org/W1966251853', 'https://openalex.org/W1972624502', 'https://openalex.org/W1974945462', 'https://openalex.org/W1976205360', 'https://openalex.org/W1976555550', 'https://openalex.org/W1976839366', 'https://openalex.org/W1985601027', 'https://openalex.org/W1988434324', 'https://openalex.org/W1991647280', 'https://openalex.org/W1994387786', 'https://openalex.org/W1994989712', 'https://openalex.org/W1995302262', 'https://openalex.org/W1996409240', 'https://openalex.org/W2001646124', 'https://openalex.org/W2015048034', 'https://openalex.org/W2016093991', 'https://openalex.org/W2025909734', 'https://openalex.org/W2027022277', 'https://openalex.org/W2029220352', 'https://openalex.org/W2030501289', 'https://openalex.org/W2030892700', 'https://openalex.org/W2031262735', 'https://openalex.org/W2034443606', 'https://openalex.org/W2037097756', 'https://openalex.org/W2039997546', 'https://openalex.org/W2041236234', 'https://openalex.org/W2050359514', 'https://openalex.org/W2051312958', 'https://openalex.org/W2059514904', 'https://openalex.org/W2064736697', 'https://openalex.org/W2069070351', 'https://openalex.org/W2072038834', 'https://openalex.org/W2073544062', 'https://openalex.org/W2086068891', 'https://openalex.org/W2088966308', 'https://openalex.org/W2092123366', 'https://openalex.org/W2102761555', 'https://openalex.org/W2104378301', 'https://openalex.org/W2112903461', 'https://openalex.org/W2116713707', 'https://openalex.org/W2120457333', 'https://openalex.org/W2121379565', 'https://openalex.org/W2121471393', 'https://openalex.org/W2125659429', 'https://openalex.org/W2126973086', 'https://openalex.org/W2127521106', 'https://openalex.org/W2128023080', 'https://openalex.org/W2136832676', 'https://openalex.org/W2140483277', 'https://openalex.org/W2142625225', 'https://openalex.org/W2144918940', 'https://openalex.org/W2145223671', 'https://openalex.org/W2147518722', 'https://openalex.org/W2152482512', 'https://openalex.org/W2153606794', 'https://openalex.org/W2159394446', 'https://openalex.org/W2161482535', 'https://openalex.org/W2162530578', 'https://openalex.org/W2164710696', 'https://openalex.org/W2165715420', 'https://openalex.org/W2169910861', 'https://openalex.org/W2314289570', 'https://openalex.org/W2341088020', 'https://openalex.org/W2396893665'], 'related_works': ['https://openalex.org/W4281711902', 'https://openalex.org/W3206555169', 'https://openalex.org/W3157359833', 'https://openalex.org/W3024317680', 'https://openalex.org/W3016573916', 'https://openalex.org/W2164855536', 'https://openalex.org/W2143489661', 'https://openalex.org/W2070581548', 'https://openalex.org/W1997352593', 'https://openalex.org/W1511048503'], 'abstract_inverted_index': {'Different': [0], 'lines': [1], 'of': [2, 47, 52, 102, 108, 165, 177, 182, 190, 195, 205, 240], 'evidence': [3, 189], 'indicate': [4], 'that': [5], 'methylenetetrahydrofolate': [6], 'reductase': [7], '(MTHFR)': [8], 'functional': [9, 61, 88, 155], 'gene': [10, 63], 'polymorphisms,': [11], 'causative': [12], 'in': [13, 69, 137, 167, 197, 242], 'aberrant': [14], 'folate-homocysteine': [15], 'metabolism,': [16], 'are': [17, 29], 'associated': [18], 'with': [19, 78, 112, 141, 174, 179], 'increased': [20], 'vulnerability': [21], 'to': [22, 43, 118], 'several': [23], 'heritable': [24], 'developmental': [25], 'disorders.': [26], 'Opposing': [27], 'views': [28], 'expressed': [30], 'considering': [31], 'the': [32, 57, 100, 106, 120, 123, 126, 151, 154, 183, 200, 206, 220], 'possible': [33], 'association': [34, 127], 'between': [35, 59, 128], 'MTHFR': [36, 62, 89, 103, 156, 207, 227], 'and': [37, 65, 82, 95, 99, 130], 'susceptibility': [38], 'for': [39, 219, 238], 'schizophrenia.': [40, 198, 243], 'In': [41, 115], 'order': [42], 'evaluate': [44], 'if': [45], 'age': [46, 66, 107, 131, 162, 176, 194, 212, 239], 'onset': [48, 68, 109, 133, 164, 178, 196, 214, 241], 'could': [49], 'explain': [50], 'some': [51], 'this': [53, 70], 'discrepancy': [54], 'we': [55], 'investigated': [56], 'relationship': [58], 'two': [60, 142], 'polymorphisms': [64, 92, 104], 'at': [67, 132, 163, 213], 'disorder.': [71], 'Scandinavian': [72, 124, 152], 'patients': [73, 153], '(n': [74, 147], '=': [75, 148, 172, 224], '820)': [76], 'diagnosed': [77], 'schizophrenia,': [79], 'schizoaffective': [80], 'disorder,': [81], 'schizophreniform': [83], 'disorder': [84], 'were': [85, 97], 'investigated.': [86], 'Two': [87], 'single': [90], 'nucleotide': [91], '(SNPs;': [93], 'rs1801131': [94, 191], 'rs1801133)': [96], 'genotyped': [98], 'effect': [101], 'on': [105], 'was': [110, 134, 187], 'examined': [111], 'survival': [113], 'analysis.': [114], 'an': [116], 'attempt': [117], 'replicate': [119], 'findings': [121], 'from': [122], 'sample,': [125], 'rs1801133': [129, 158], 'also': [135], 'analyzed': [136], 'Chinese': [138, 201], 'high-risk': [139, 202], 'families,': [140], 'or': [143], 'more': [144], 'affected': [145, 161], 'siblings': [146, 216], '243).': [149], 'Among': [150], 'SNP': [157], '(C677T)': [159], 'significantly': [160], 'schizophrenia': [166], 'a': [168, 232, 235], 'dose-dependent': [169], 'manner': [170], '(P': [171, 223], '0.0015),': [173], 'lower': [175], 'increasing': [180], 'numbers': [181], 'mutant': [184], 'T-allele.': [185], 'There': [186], 'no': [188], '(A1298C)': [192], 'affecting': [193], 'Within': [199], 'families': [203], 'carriers': [204], '677T': [208], 'allele': [209, 222], 'showed': [210], 'earlier': [211], 'than': [215], 'being': [217], 'homozygous': [218], 'wild-type': [221], '0.008).': [225], 'The': [226], 'C677T': [228], 'polymorphism': [229], 'may': [230], 'play': [231], 'role': [233], 'as': [234], 'modifying': [236], 'factor': [237]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2063455907', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2025-01-10T15:05:12.573838', 'created_date': '2016-06-24'}