Title: 112. Temporal lobe volume in schizotypal personality disorder and schizophrenia
Abstract: The volumes of the whole temporal lobe, the superior temporal gyrus and the corpus callosum were measured on MRI images from 27 patients with schizophrenia, 13 patients with schizotypal personality disorder (SPD) and 31 sex- and age-matched controls. The temporal lobe and superior temporal gyrus were traced on consecutive 1.2 mm thick SPGR coronal images from the anteriormost appearance of an uninterrupted temporal stem on each side to the posteriormost appearance of fibers in the crux of the fornix. From these consecutive slices, total and volumes relative to the whole brain were determined. Patients with SPD and schizophrenia had smaller temporal lobe gray matter primarily in the area outside the superior temporal gyrus. Correction for brain size diminished normal/schizophrenia differences but the normal/schizotypal differences remained, suggesting greater regional specificity for temporal lobe volume loss in schizotypal than schizophrenic patients. Higher scores on the Brief Psychiatric Rating scale and lower scores on verbal memory tasks were associated with temporal volume loss in patients with schizophrenia but not those with SPD. Temporal lobe gray/white volume correlations were positive in controls, non-significant in schizophrenia patients but negative in SPD patients. Both normal individuals and SPD patients showed significant correlations between the area of the posterior portion of the corpus callosum (which carries temporal interhemispheric connections) and the white matter volume of the temporal lobe.
Publication Year: 2000
Publication Date: 2000-04-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 3
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