Zinc-induced Alzheimer's Aβ1–40 Aggregation Is Mediated by Conformational Factors

Name: Work Video:
Duration: 3 min 30 s
Xudong Huang; Craig Atwood; Robert D. Moir; Mariana A. Hartshorn; Jean‐Paul Vonsattel; Rudolph E. Tanzi; Ashley I. Bush
{'id': 'https://openalex.org/W2063281989', 'doi': 'https://doi.org/10.1074/jbc.272.42.26464', 'title': "Zinc-induced Alzheimer's Aβ1–40 Aggregation Is Mediated by Conformational Factors", 'display_name': "Zinc-induced Alzheimer's Aβ1–40 Aggregation Is Mediated by Conformational Factors", 'publication_year': 1997, 'publication_date': '1997-10-01', 'ids': {'openalex': 'https://openalex.org/W2063281989', 'doi': 'https://doi.org/10.1074/jbc.272.42.26464', 'mag': '2063281989', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9334223'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.272.42.26464', 'pdf_url': 'http://www.jbc.org/article/S0021925818664403/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925818664403/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5080825168', 'display_name': 'Xudong Huang', 'orcid': 'https://orcid.org/0000-0002-4811-1901'}, 'institutions': [{'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xudong Huang', 'raw_affiliation_strings': ['Department of Psychiatry and the Genetics and Aging Unit, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114'], 'affiliations': [{'raw_affiliation_string': 'Department of Psychiatry and the Genetics and Aging Unit, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114', 'institution_ids': ['https://openalex.org/I4210087915', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067709976', 'display_name': 'Craig Atwood', 'orcid': 'https://orcid.org/0000-0001-5040-1679'}, 'institutions': [{'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Craig S. Atwood', 'raw_affiliation_strings': ['Department of Psychiatry and the Genetics and Aging Unit, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114'], 'affiliations': [{'raw_affiliation_string': 'Department of Psychiatry and the Genetics and Aging Unit, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114', 'institution_ids': ['https://openalex.org/I4210087915', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008848229', 'display_name': 'Robert D. Moir', 'orcid': 'https://orcid.org/0000-0001-5431-3553'}, 'institutions': [{'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert D. Moir', 'raw_affiliation_strings': ['Department of Neurology and the Genetics and Aging Unit, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology and the Genetics and Aging Unit, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114', 'institution_ids': ['https://openalex.org/I4210087915', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007388550', 'display_name': 'Mariana A. Hartshorn', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mariana A. Hartshorn', 'raw_affiliation_strings': ['Department of Psychiatry and the Genetics and Aging Unit, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114'], 'affiliations': [{'raw_affiliation_string': 'Department of Psychiatry and the Genetics and Aging Unit, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114', 'institution_ids': ['https://openalex.org/I4210087915', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111959906', 'display_name': 'Jean‐Paul Vonsattel', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jean-Paul Vonsattel', 'raw_affiliation_strings': ['Department of Pathology and, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114', 'institution_ids': ['https://openalex.org/I4210087915', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050004777', 'display_name': 'Rudolph E. Tanzi', 'orcid': 'https://orcid.org/0000-0002-7032-1454'}, 'institutions': [{'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rudolph E. Tanzi', 'raw_affiliation_strings': ['Department of Neurology and the Genetics and Aging Unit, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology and the Genetics and Aging Unit, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114', 'institution_ids': ['https://openalex.org/I4210087915', 'https://openalex.org/I136199984']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5038374630', 'display_name': 'Ashley I. Bush', 'orcid': 'https://orcid.org/0000-0001-8259-9069'}, 'institutions': [{'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ashley I. Bush', 'raw_affiliation_strings': ['Department of Psychiatry and the Genetics and Aging Unit, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114'], 'affiliations': [{'raw_affiliation_string': 'Department of Psychiatry and the Genetics and Aging Unit, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114', 'institution_ids': ['https://openalex.org/I4210087915', 'https://openalex.org/I136199984']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 3.807, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 307, 'citation_normalized_percentile': {'value': 0.970827, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '272', 'issue': '42', 'first_page': '26464', 'last_page': '26470'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10915', 'display_name': 'Trace Elements in Health', 'score': 0.9949, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 0.9784, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/neurochemical', 'display_name': 'Neurochemical', 'score': 0.521177}], 'concepts': [{'id': 'https://openalex.org/C535196362', 'wikidata': 'https://www.wikidata.org/wiki/Q758', 'display_name': 'Zinc', 'level': 2, 'score': 0.81324923}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.70570815}, {'id': 'https://openalex.org/C2779281246', 'wikidata': 'https://www.wikidata.org/wiki/Q172847', 'display_name': 'Peptide', 'level': 2, 'score': 0.689758}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.65579724}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.57201993}, {'id': 'https://openalex.org/C25876315', 'wikidata': 'https://www.wikidata.org/wiki/Q15197465', 'display_name': 'Neurochemical', 'level': 2, 'score': 0.521177}, {'id': 'https://openalex.org/C2779546866', 'wikidata': 'https://www.wikidata.org/wiki/Q531306', 'display_name': 'Dimer', 'level': 2, 'score': 0.51437104}, {'id': 'https://openalex.org/C136238340', 'wikidata': 'https://www.wikidata.org/wiki/Q7251455', 'display_name': 'Protein aggregation', 'level': 2, 'score': 0.48785138}, {'id': 'https://openalex.org/C197404232', 'wikidata': 'https://www.wikidata.org/wiki/Q319827', 'display_name': 'Chelation', 'level': 2, 'score': 0.45962206}, {'id': 'https://openalex.org/C27523624', 'wikidata': 'https://www.wikidata.org/wiki/Q14860849', 'display_name': 'Fibril', 'level': 2, 'score': 0.4436289}, {'id': 'https://openalex.org/C107054158', 'wikidata': 'https://www.wikidata.org/wiki/Q25257', 'display_name': 'Precipitation', 'level': 2, 'score': 0.4401628}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.42912656}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.19132459}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.18778011}, {'id': 'https://openalex.org/C179104552', 'wikidata': 'https://www.wikidata.org/wiki/Q11165', 'display_name': 'Inorganic chemistry', 'level': 1, 'score': 0.16522792}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.13935098}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C153294291', 'wikidata': 'https://www.wikidata.org/wiki/Q25261', 'display_name': 'Meteorology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016229', 'descriptor_name': 'Amyloid beta-Peptides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015032', 'descriptor_name': 'Zinc', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016229', 'descriptor_name': 'Amyloid beta-Peptides', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D016229', 'descriptor_name': 'Amyloid beta-Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002850', 'descriptor_name': 'Chromatography, Gel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015032', 'descriptor_name': 'Zinc', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.272.42.26464', 'pdf_url': 'http://www.jbc.org/article/S0021925818664403/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9334223', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.272.42.26464', 'pdf_url': 'http://www.jbc.org/article/S0021925818664403/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 52, 'referenced_works': ['https://openalex.org/W1503503847', 'https://openalex.org/W1510383592', 'https://openalex.org/W1516306407', 'https://openalex.org/W1536258113', 'https://openalex.org/W157666778', 'https://openalex.org/W1600007560', 'https://openalex.org/W1946646142', 'https://openalex.org/W1960543132', 'https://openalex.org/W1972127455', 'https://openalex.org/W1976820443', 'https://openalex.org/W1979543098', 'https://openalex.org/W1980803588', 'https://openalex.org/W1981545549', 'https://openalex.org/W1982188419', 'https://openalex.org/W1982635793', 'https://openalex.org/W1983594867', 'https://openalex.org/W1991647860', 'https://openalex.org/W1996216953', 'https://openalex.org/W1999206064', 'https://openalex.org/W2017643275', 'https://openalex.org/W2019067064', 'https://openalex.org/W2032665239', 'https://openalex.org/W2032920422', 'https://openalex.org/W2033382511', 'https://openalex.org/W2037800112', 'https://openalex.org/W2038012168', 'https://openalex.org/W2040872965', 'https://openalex.org/W2041802741', 'https://openalex.org/W2042538218', 'https://openalex.org/W2046423382', 'https://openalex.org/W2046847750', 'https://openalex.org/W2057054940', 'https://openalex.org/W2059214757', 'https://openalex.org/W2066991374', 'https://openalex.org/W2071691905', 'https://openalex.org/W2071953900', 'https://openalex.org/W2074666645', 'https://openalex.org/W2076767192', 'https://openalex.org/W2079402113', 'https://openalex.org/W2086278983', 'https://openalex.org/W2087969945', 'https://openalex.org/W2094337931', 'https://openalex.org/W2094411486', 'https://openalex.org/W2094808560', 'https://openalex.org/W2095124740', 'https://openalex.org/W2095361799', 'https://openalex.org/W2098079657', 'https://openalex.org/W2123321976', 'https://openalex.org/W2130144581', 'https://openalex.org/W2148999943', 'https://openalex.org/W2416387777', 'https://openalex.org/W2462485662'], 'related_works': ['https://openalex.org/W2625887310', 'https://openalex.org/W2203126829', 'https://openalex.org/W2148659044', 'https://openalex.org/W2064575213', 'https://openalex.org/W2046119669', 'https://openalex.org/W2004828335', 'https://openalex.org/W1981236562', 'https://openalex.org/W137827551', 'https://openalex.org/W125047944', 'https://openalex.org/W113698325'], 'abstract_inverted_index': {'The': [0, 79, 120, 171, 234, 313, 354, 405, 468, 1010, 1571, 2363, 2459, 2588, 2634, 2720, 2753, 2778, 2905, 3148, 3427, 3461, 3600, 4020, 4409], 'heterogeneous': [1, 235, 489], 'precipitates': [2, 236, 888], 'of': [3, 17, 34, 60, 102, 180, 210, 225, 228, 237, 251, 268, 294, 336, 414, 444, 459, 462, 471, 481, 550, 697, 869, 886, 1018, 1024, 1029, 1039, 1097, 1110, 1145, 1226, 1324, 1328, 1376, 1500, 1521, 1525, 1553, 1568, 1573, 1631, 1638, 1666, 1735, 1816, 1853, 1874, 1879, 1962, 1997, 2007, 2063, 2079, 2086, 2100, 2108, 2127, 2161, 2188, 2194, 2229, 2263, 2286, 2292, 2367, 2388, 2411, 2489, 2517, 2524, 2620, 2625, 2636, 2643, 2759, 2767, 2790, 2802, 3016, 3057, 3114, 3150, 3161, 3215, 3230, 3232, 3293, 3318, 3325, 3343, 3376, 3381, 3405, 3512, 3529, 3597, 3612, 3635, 3654, 3744, 3773, 3781, 3796, 3801, 3817, 3829, 3846, 3861, 3882, 3886, 3897, 3972, 4048, 4059, 4075, 4147, 4151, 4162, 4181, 4202, 4291, 4304, 4316, 4346, 4356, 4362, 4404, 4413, 4425, 4430, 4440, 4467, 4476, 4514, 4520, 4525, 4546], 'Aβ': [4, 46, 61, 95, 121, 154, 195, 229, 238, 280, 295, 329, 355, 388, 429, 463, 545, 671, 887, 938, 1026, 1098, 1111, 1156, 1274, 1334, 1450, 1501, 1526, 1557, 1643, 1667, 1858, 1923, 1958, 1973, 2020, 2071, 2087, 2101, 2287, 2426, 2509, 2644, 2803, 3531, 3656, 3802, 3847, 3887, 3899, 4137, 4203, 4319], 'that': [5, 24, 38, 56, 72, 141, 239, 258, 272, 290, 306, 375, 669, 684, 892, 937, 1143, 1186, 1368, 1424, 1516, 1618, 1723, 1870, 1882, 2157, 2184, 2205, 2220, 2259, 2282, 2393, 3709, 3748, 3769, 3792, 3805, 3826, 3849, 3889, 3979, 4193, 4285, 4313, 4429, 4457], 'accumulate': [6, 240], 'in': [7, 11, 29, 42, 81, 148, 186, 206, 213, 231, 241, 245, 263, 276, 315, 382, 420, 440, 447, 465, 478, 491, 557, 559, 679, 690, 874, 880, 1418, 1429, 1444, 1528, 1560, 1579, 1583, 1646, 1738, 1811, 1860, 1927, 1982, 2074, 2201, 2288, 2295, 2304, 2370, 2373, 2382, 2463, 2482, 2497, 2562, 2647, 2692, 2912, 2958, 2975, 3029, 3066, 3125, 3236, 3297, 3315, 3353, 3384, 3431, 3466, 3535, 3570, 3585, 3644, 3703, 3716, 3741, 3820, 3858, 3879, 3894, 3903, 3968, 4045, 4068, 4086, 4096, 4134, 4141, 4170, 4297, 4326, 4406, 4417, 4432, 4448, 4464], 'the': [8, 57, 83, 100, 113, 142, 149, 166, 177, 207, 223, 232, 242, 291, 317, 334, 347, 376, 383, 400, 411, 441, 457, 466, 475, 479, 492, 560, 687, 866, 870, 1025, 1030, 1035, 1095, 1107, 1114, 1266, 1322, 1326, 1329, 1332, 1370, 1373, 1419, 1433, 1445, 1498, 1506, 1519, 1554, 1566, 1632, 1636, 1639, 1664, 1730, 1814, 1851, 1880, 1960, 1963, 1983, 1991, 2008, 2061, 2077, 2084, 2089, 2113, 2117, 2120, 2159, 2185, 2202, 2208, 2218, 2227, 2260, 2264, 2284, 2289, 2293, 2383, 2389, 2464, 2515, 2518, 2522, 2637, 2641, 2707, 2760, 2788, 2794, 2800, 2950, 2956, 2959, 3014, 3072, 3090, 3097, 3112, 3145, 3151, 3159, 3183, 3187, 3213, 3216, 3228, 3233, 3237, 3253, 3269, 3282, 3286, 3374, 3377, 3403, 3499, 3510, 3515, 3530, 3595, 3598, 3606, 3641, 3652, 3706, 3742, 3749, 3770, 3774, 3779, 3794, 3797, 3815, 3818, 3827, 3838, 3859, 3862, 3867, 3880, 3883, 3895, 3898, 3904, 3980, 4027, 4046, 4057, 4069, 4080, 4087, 4103, 4109, 4135, 4142, 4145, 4160, 4171, 4179, 4182, 4199, 4286, 4302, 4305, 4314, 4317, 4330, 4336, 4343, 4402, 4407, 4426, 4444, 4458, 4465, 4543], 'brain': [9, 43, 243, 277, 480, 1531, 2294], 'cortex': [10, 244], "Alzheimer's": [12, 214, 246, 448, 472, 881, 1569, 2296], 'disease': [13, 215, 247, 449, 473], 'possess': [14, 248], 'varying': [15, 249], 'degrees': [16, 250], 'resistance': [18, 252], 'to': [19, 50, 90, 169, 253, 284, 324, 403, 674, 699, 1015, 1432, 1502, 1505, 1565, 1576, 1627, 1856, 1956, 1970, 1978, 2001, 2018, 2198, 2440, 2521, 2564, 2585, 2612, 2616, 2669, 2821, 2953, 2970, 3122, 3156, 3185, 3190, 3398, 3401, 3422, 3424, 3438, 3471, 3526, 3622, 3626, 3756, 3762, 3786, 3813, 3832, 3877, 4035, 4056, 4079, 4102, 4115, 4131, 4165, 4197, 4301, 4324, 4401, 4423, 4471], 'resolubilization.': [20, 254], 'We': [21, 52, 255, 286, 933, 1140, 1366, 2181, 4282, 4334, 4469], 'previously': [22, 256], 'found': [23, 257, 556, 873, 1142, 1514, 3747, 4422], 'Aβ1–40': [25, 259, 1152, 1223, 1578, 2189, 2299, 2368, 2626, 2687, 2779, 2791, 2967, 3018, 3026, 3117, 3119, 3344, 3382, 3428, 3462, 3569, 3578, 3710, 3973, 4049, 4060, 4076, 4167, 4294, 4405, 4431, 4528, 4540, 4547], 'is': [26, 39, 47, 62, 86, 145, 204, 260, 273, 281, 296, 320, 379, 438, 474, 546, 555, 872, 995, 1000, 1187, 1257, 1413, 1427, 1442, 1658, 1844, 1867, 1873, 1883, 1954, 1987, 2096, 2104, 2196, 3711, 3776, 4129, 4169, 4188], 'rapidly': [27, 261, 1149], 'precipitated': [28, 262], 'vitro': [30, 264, 1561, 1580], 'by': [31, 64, 70, 106, 124, 128, 135, 157, 164, 265, 298, 304, 340, 358, 362, 369, 391, 398, 896, 1002, 1112, 1259, 1589, 1652, 1885, 1932, 2102, 2190, 2270, 2311, 2350, 2471, 2629, 2652, 2764, 2798, 2934, 3158, 3349, 3519, 3974, 4184], 'physiological': [32, 266], 'concentrations': [33, 267, 558, 1144, 1203, 1460, 1619, 1725, 1996, 2193, 2462, 2646, 4446, 4475], 'zinc,': [35, 269, 944, 1191, 1325, 1669, 2985], 'a': [36, 65, 202, 218, 270, 299, 436, 452, 483, 547, 680, 691, 883, 955, 969, 1016, 1249, 1416, 1522, 1659, 1980, 2066, 2105, 2110, 2170, 2379, 2414, 2448, 2582, 2595, 2670, 2913, 2928, 3050, 3077, 3080, 3194, 3197, 3222, 3331, 3504, 3527, 3617, 3645, 3788, 3807, 4117, 4148, 4189, 4350, 4352, 4395], 'neurochemical': [37, 271], 'highly': [40, 274, 875, 1188, 2171], 'abundant': [41, 275, 476, 1443, 1731, 3799], 'compartments': [44, 278], 'where': [45, 279, 553, 1449, 2555], 'most': [48, 282, 1453, 2965, 3798], 'likely': [49, 283], 'precipitate.': [51, 285], 'now': [53, 287, 667, 2182], 'present': [54, 288], 'evidence': [55, 289, 1515, 4513], 'zinc-induced': [58, 292, 3017, 3408], 'precipitation': [59, 293, 1157, 1380, 1630, 1734, 2085, 2187, 2271, 4168], 'mediated': [63, 297], 'peptide': [66, 85, 114, 300, 319, 348, 689, 871, 1115, 1371, 2091, 2179, 2265, 2301, 2369, 2391, 2412, 2510, 2558, 2589, 2621, 2645, 2809, 3275, 3352, 3411, 3513, 3601, 3642, 3775, 3819, 3888, 3981, 4050, 4138, 4153, 4183, 4320, 4398, 4460, 4477], 'dimer': [67, 301, 3987], 'and': [68, 75, 216, 302, 309, 450, 496, 941, 959, 1091, 1104, 1195, 1233, 1241, 1256, 1331, 1409, 1456, 1544, 1558, 1710, 1732, 1810, 1934, 2073, 2125, 2166, 2211, 2226, 2309, 2347, 2428, 2445, 2491, 2568, 2608, 2715, 2731, 2748, 2756, 2772, 2787, 2921, 2999, 3023, 3040, 3075, 3094, 3136, 3166, 3192, 3212, 3267, 3278, 3434, 3452, 3455, 3488, 3491, 3509, 3614, 3630, 3699, 3730, 3901, 3995, 4026, 4108, 4438, 4480, 4533, 4550], 'favored': [69, 303], 'conditions': [71, 305, 3249, 3804, 4473], 'promote': [73, 307], 'α-helical': [74, 308], 'diminish': [76, 310], 'β-sheet': [77, 311, 682, 867], 'conformations.': [78, 312], 'manner': [80, 314], 'which': [82, 316, 1033, 1269, 4052, 4348, 4485], 'synthetic': [84, 318, 670, 688, 2164, 2390, 3568], 'solubilized': [87, 321, 2561], 'was': [88, 97, 104, 110, 117, 322, 331, 338, 344, 351, 1013, 1650, 2302, 2376, 2406, 2423, 2495, 2559, 2591, 2650, 2704, 2722, 2782, 2796, 2818, 2947, 2968, 3120, 3139, 3153, 3180, 3218, 3271, 3288, 3328, 3469, 3517, 3576, 3582, 3603, 4299, 4421], 'critical': [89, 323, 1428, 2614], 'its': [91, 325, 3137, 3588, 3758, 4127], 'behaviorin': [92, 326], 'vitro.': [93, 327], 'Zinc-induced': [94, 328], 'aggregation': [96, 330, 1200, 1644, 2817, 3231, 3532, 4200], 'dependent': [98, 332, 3777], 'upon': [99, 333, 2083, 2207, 3407, 3714, 3778, 3837, 4123], 'presence': [101, 335, 3653, 3780, 4146, 4315, 4466], 'NaCl,': [103, 337, 2701, 2996, 3032, 3128, 3444, 3477, 3745], 'enhanced': [105, 339], 'α-helical-promoting': [107, 341], 'solvents,': [108, 342], 'but': [109, 130, 343, 364], 'abolished': [111, 345, 1001], 'when': [112, 346, 678], 'stock': [115, 349, 2430, 2478, 3429, 3463], 'solution': [116, 350, 693, 2479, 3152, 3464, 3579, 3602, 4524], 'stored': [118, 352, 3392], 'frozen.': [119, 353], 'aggregates': [122, 155, 356, 389, 2957], 'induced': [123, 156, 357, 390], 'zinc': [125, 136, 359, 370, 1146, 1245, 1260, 1431, 1441, 1459, 1517, 1559, 1574, 1724, 1854, 1881, 1953, 1964, 1976, 1998, 2010, 2082, 2162, 2195, 2333, 2461, 2477, 3022, 3064, 4163, 4338, 4354, 4445, 4481, 4553], 'were': [126, 161, 360, 395, 1977, 2395, 2434, 2466, 2503, 2512, 2627, 2657, 2762, 2907, 2925, 3007, 3027, 3043, 3069, 3084, 3099, 3169, 3201, 3208, 3250, 3304, 3347, 3391, 3413, 3436, 3501, 3890, 4077, 4517, 4554], 'reversible': [127, 194, 361, 428], 'chelation,': [129, 363], 'could': [131, 197, 365, 431, 4510], 'then': [132, 366, 1865, 2004, 2569, 2592, 3154], 'be': [133, 198, 367, 432, 894, 1563, 1918, 1930, 1979, 2016, 2268, 2613, 3763, 4031, 4113, 4132, 4155, 4424], 'reprecipitated': [134, 368], 'for': [137, 222, 371, 456, 1190, 1497, 1642, 1662, 1846, 1920, 2069, 2112, 2119, 2177, 2425, 2572, 2640, 2816, 2949, 3101, 3264, 3273, 3300, 3335, 3396, 3418, 3866, 4353, 4399, 4484, 4523], 'several': [138, 372], 'cycles,': [139, 373], 'indicating': [140, 374, 4312, 4456], "peptide's": [143, 377, 1984, 2209, 3750], 'conformation': [144, 378, 683, 868, 2210], 'probably': [146, 380, 996], 'preserved': [147, 381], 'zinc-mediated': [150, 181, 384, 415, 1379], 'assembly.': [151, 385], 'In': [152, 386, 1321, 1634, 2964], 'contrast,': [153, 387], 'low': [158, 392, 561, 960, 1994, 2080, 2191, 4172], 'pH': [159, 167, 393, 401, 1004, 1008, 2702, 2986, 2997, 3036, 3115, 3132, 3149, 3188, 3214, 3223, 3358, 3447, 3483, 4419], '(5.5)': [160, 394], 'not': [162, 396, 1917, 2267, 3766, 4112, 4310, 4322, 4436, 4452, 4462], 'resolubilized': [163, 397, 895], 'returning': [165, 399], 'milieu': [168, 402, 2204], '7.4.': [170, 404], 'zinc-Aβ': [172, 406], 'interaction': [173, 407, 1665, 1872, 2025, 2160], 'exhibits': [174, 408], 'features': [175, 409], 'resembling': [176, 410], 'gelation': [178, 412], 'process': [179, 413], 'fibrin': [182, 416], 'assembly,': [183, 417, 2021], 'suggesting': [184, 418, 1494, 3768], 'that,': [185, 419], 'events': [187, 421], 'such': [188, 422, 2023], 'as': [189, 423, 487, 2065, 2169, 2378, 2413, 2813, 3144, 3210, 3616, 3984, 4033, 4394, 4428], 'clot': [190, 424], 'formation': [191, 425], 'or': [192, 426, 2989, 3061, 3247, 3285, 3360, 3364, 3389, 3853, 4064, 4173], 'injury,': [193, 427], 'assembly': [196, 430, 1520], 'physiologically': [199, 433, 3808], 'purposive.': [200, 434], 'Such': [201, 435], 'mechanism': [203, 437], 'contemplated': [205, 439], 'early': [208, 442], 'evolution': [209, 443], 'diffuse': [211, 445], 'plaques': [212, 446], 'suggests': [217, 451], 'possible': [219, 453], 'therapeutic': [220, 454], 'strategy': [221, 455], 'resolubilization': [224, 458], 'some': [226, 460], 'forms': [227, 461], 'deposit': [230, 464, 1503], 'disease.': [233, 467, 1570, 2297], 'pathological': [469], 'hallmark': [470], 'accumulation': [477], 'Aβ,': [482, 2003], '39–43-amino': [484], 'acid': [485, 2345, 2386, 2402, 2654], 'peptide,': [486, 3900], 'morphologically': [488], 'deposits': [490, 879, 891, 1451, 1527], 'neuropil': [493], '(senile': [494], 'plaques)': [495], 'cerebral': [497, 1273], 'blood': [498], 'vessels': [499], '(congophilic': [500], 'angiopathy)': [501], '(1Glenner': [502], 'G.G.': [503], 'Wong': [504], 'C.W.': [505, 721, 739, 758, 778, 798], 'Biochem.': [506, 817], 'Biophys.': [507, 818, 3934, 3953], 'Res.': [508, 723, 760, 819, 1287, 1290], 'Commun.': [509, 820], '1984;': [510, 1471, 1486, 1893, 1908], '120:': [511], '885-890Crossref': [512], 'PubMed': [513, 540, 590, 629, 660, 711, 727, 746, 764, 784, 804, 824, 846, 860, 928, 990, 1062, 1081, 1137, 1181, 1216, 1294, 1316, 1361, 1404, 1474, 1489, 1610, 1692, 1762, 1788, 1805, 1837, 1896, 1911, 1945, 2055, 2148, 2250, 2549, 2845, 2859, 2881, 2897, 3561, 3676, 3696, 3921, 3942, 3961, 4017, 4225, 4239, 4261, 4277, 4391, 4505], 'Scopus': [514, 541, 591, 630, 661, 712, 728, 747, 765, 805, 825, 861, 929, 1063, 1082, 1182, 1217, 1295, 1317, 1362, 1405, 1475, 1490, 1611, 1693, 1789, 1806, 1838, 1897, 1912, 1946, 2056, 2149, 2251, 2550, 2846, 2860, 2882, 2898, 3562, 3677, 3922, 3943, 3962, 4226, 4240, 4262, 4278, 4506], '(4379)': [515], 'Google': [516, 543, 593, 632, 663, 714, 730, 749, 767, 785, 807, 827, 847, 863, 931, 991, 1065, 1084, 1138, 1184, 1219, 1297, 1319, 1364, 1407, 1477, 1492, 1613, 1695, 1763, 1791, 1808, 1840, 1899, 1914, 1948, 2058, 2151, 2253, 2552, 2848, 2862, 2884, 2900, 3564, 3679, 3697, 3924, 3945, 3964, 4018, 4228, 4242, 4264, 4280, 4392, 4508], 'Scholar,': [517, 594, 633, 715, 731, 750, 768, 786, 808, 828, 848, 1066, 1298, 1478, 1764, 1792, 1900, 2849, 2863, 2885, 3680, 3925, 3946, 4229, 4243, 4265], '2Masters': [518], 'C.L.': [519, 1174, 1354, 1397, 1781, 2048, 3554, 3667, 4381], 'Simms': [520], 'G.': [521, 525, 1164, 1304, 1344, 1387, 1713, 1771, 2038, 3544, 3733, 4367], 'Weinman': [522], 'N.A.': [523], 'Multhaup': [524, 1163, 1303, 1343, 1386, 1770, 2037, 3543, 4366], 'McDonald': [526], 'B.L.': [527, 575], 'Beyreuther': [528, 1071, 1171, 1307, 1351, 1394, 1778, 2045, 3551, 3668, 4378], 'K.': [529, 836, 1072, 1172, 1308, 1352, 1395, 1536, 1779, 2046, 3552, 3669, 4379], 'Proc.': [530, 2539, 2835, 2871, 4215, 4251], 'Natl.': [531, 2540, 2836, 2872, 4216, 4252], 'Acad.': [532, 2541, 2837, 2873, 4217, 4253], 'Sci.': [533, 2542, 2838, 2874, 4218, 4254], 'U.': [534, 2485, 2543, 2839, 2875, 4219, 4255], 'S.': [535, 608, 643, 2486, 2544, 2840, 2876, 4220, 4256], 'A.': [536, 573, 852, 1074, 1534, 1545, 2545, 2841, 2877, 3910, 4221, 4257], '1985;': [537], '82:': [538], '4245-4249Crossref': [539], '(3791)': [542], 'Scholar).': [544, 664, 864, 932, 992, 1139, 1220, 1320, 1365, 1696, 1841, 1949, 2254, 3565, 3739, 3965, 4019, 4281], 'soluble': [548, 1736, 4318], 'component': [549], 'cerebrospinal': [551], 'fluid': [552], 'it': [554, 999, 1866, 1925, 4187], 'nanomolar': [562], 'range': [563], '(3Haass': [564], 'C.': [565, 571, 598, 614, 906, 1302, 1541, 1712, 3686, 3732], 'Schlossmacher': [566, 609], 'M.G.': [567, 1482, 1904, 3914], 'Hung': [568], 'A.Y.': [569], 'Vigo-Pelfrey': [570, 597, 905], 'Mellon': [572], 'Ostaszewski': [574], 'Lieberburg': [576, 621, 837], 'I.': [577, 622, 838, 1546], 'Koo': [578, 1069], 'E.H.': [579, 1070], 'Schenk': [580, 623], 'D.': [581, 606, 620, 624, 772, 834, 1055], 'Teplow': [582], 'D.B.': [583], 'Selkoe': [584, 619], 'D.S.': [585], 'Nature.': [586, 625, 1470, 1485, 1892, 1907], '1992;': [587, 626, 657, 843, 857, 2856, 3918, 4236], '359:': [588, 627], '322-325Crossref': [589], '(1779)': [592], '4Seubert': [595], 'P.': [596, 4377], 'Esch': [599], 'F.': [600, 3931], 'Lee': [601], 'M.': [602, 610, 635, 978, 1125, 1306, 1750, 2352, 4005], 'Dovey': [603], 'H.': [604], 'Davis': [605, 833], 'Sinha': [607], 'Whaley': [611], 'J.': [612, 639, 735, 741, 754, 774, 779, 792, 799, 841, 850, 917, 981, 1128, 1312, 1605, 1687, 1714, 1753, 1832, 2143, 2245, 3665, 3670, 3684, 3687, 3734, 3915, 3935, 3954, 4008, 4382, 4500], 'Swindelhurst': [613], 'McCormack': [615], 'R.': [616, 618, 651, 840, 1283, 1538], 'Wolfert': [617], '325-327Crossref': [628], '(1624)': [631], '5Shoji': [634], 'Golde': [636], 'T.E.': [637], 'Ghiso': [638], 'Cheung': [640], 'T.T.': [641], 'Estus': [642], 'Shaffer': [644], 'L.M.': [645], 'Cai': [646], 'X.-D.': [647], 'McKay': [648], 'D.M.': [649], 'Tintner': [650], 'Frangione': [652], 'B.': [653, 832, 3663, 3682, 4375], 'Younkin': [654], 'S.G.': [655], 'Science.': [656, 707, 1058, 1077, 1177, 1212, 1357, 1400, 1784, 1801, 2051, 3557], '258:': [658], '126-129Crossref': [659], '(1334)': [662], 'Many': [665], 'studies': [666, 3841], 'indicate': [668, 2258], 'becomes': [672], 'toxic': [673], 'cultured': [675], 'neuronal': [676], 'cells': [677], 'specific': [681, 1189, 3884], 'involves': [685], 'incubating': [686], 'aqueous': [692, 899], 'over': [694, 1862], 'time': [695, 3258, 4331], 'periods': [696], 'days': [698], 'weeks': [700], '(6Yankner': [701], 'B.A.': [702, 854], 'Duffy': [703], 'L.K.': [704], 'Kirschner': [705], 'D.A.': [706], '1990;': [708, 724, 1059, 1078], '250:': [709], '279-282Crossref': [710], '(1948)': [713], '7Koh': [716], 'J.-Y.': [717], 'Yang': [718], 'L.L.': [719], 'Cotman': [720, 738, 757, 777, 797], 'Brain': [722, 759, 1286, 1289], '533:': [725], '315-320Crossref': [726], '(623)': [729], '8Pike': [732], 'C.J.': [733, 752, 770, 788, 1484, 1906, 1938, 3908], 'Walencewicz': [734, 753, 773], 'Glabe': [736, 755, 775, 795, 3685], 'C.G.': [737, 756, 776, 796], 'Eur.': [740], 'Pharmacol.': [742], '1991;': [743, 761, 821, 1291, 3673], '207:': [744], '367-368Crossref': [745], '(268)': [748], '9Pike': [751], '563:': [762], '311-314Crossref': [763], '(834)': [766], '10Pike': [769], 'Burdick': [771], 'Neurosci.': [780, 842], '1993;': [781, 2878, 2894, 3936, 4258, 4274, 4385], '13:': [782, 858], '1676-1687Crossref': [783], '11Pike': [787], 'Walencewicz-Wasserman': [789], 'A.J.': [790], 'Kosmoski': [791, 3683], 'Cribbs': [793], 'D.H.': [794, 4373], 'Neurochem.': [800, 1606, 1688, 1833, 2144, 2246, 4501], '1995;': [801, 1213, 1802, 2546, 2842, 4222], '64:': [802], '253-265Crossref': [803], '(688)': [806], '12Roher': [809], 'A.E.': [810, 916], 'Ball': [811, 913], 'M.J.': [812, 914], 'Bhave': [813], 'S.V.': [814], 'Wakade': [815], 'A.R.': [816, 1051], '174:': [822], '572-579Crossref': [823], '(105)': [826], '13Mattson': [829], 'M.P.': [830], 'Cheng': [831], 'Bryant': [835], 'Rydel': [839], '12:': [844], '376-389Crossref': [845], '14Busciglio': [849], 'Lorenzo': [851], 'Yankner': [853], 'Neubiol.': [855], 'Aging.': [856], '609-612Crossref': [859], '(207)': [862], 'Whereas': [865], 'insoluble': [876], 'fibrillar': [877], 'amyloid': [878, 1100, 1275, 2300, 2340], 'disease,': [882], 'substantial': [884], 'proportion': [885, 4128, 4150], 'into': [889, 898, 2279, 2706, 3071, 3182, 4062], 'nonfibrillar': [890], 'can': [893, 1197, 4030], 'extraction': [897], 'solvents': [900], '(15Kuo': [901], 'Y.-M.': [902], 'Emmerling': [903], 'M.R.': [904], 'Kasunic': [907], 'T.C.': [908], 'Kirkpatrick': [909], 'J.B.': [910], 'Murdoch': [911], 'G.H.': [912], 'Roher': [915], 'Biol.': [918, 982, 1129, 1701, 1715, 1754, 3672, 3688, 3721, 3735, 3917, 4009, 4383], 'Chem.': [919, 983, 1130, 1702, 1755, 3689, 3722, 4010, 4384], '1996;': [920, 1607, 1689, 1834, 2145, 2247, 4502], '271:': [921], '4077-4081Abstract': [922], 'Full': [923, 925, 987, 1134, 1759, 3693, 3939, 3958, 4014, 4388], 'Text': [924, 926, 988, 1135, 1760, 3694, 3940, 3959, 4015, 4389], 'PDF': [927, 989, 1136, 1761, 3695, 3941, 3960, 4016, 4390], '(559)': [930], 'have': [934, 1512, 1616, 1720, 3650, 3842, 3874, 4042, 4054], 'recently': [935, 1588, 1721], 'reported': [936, 1587, 1722, 3651, 3843, 3892], 'itself': [939], 'specifically': [940], 'saturably': [942], 'binds': [943, 1244], 'manifesting': [945], 'high': [946, 1457, 2318, 4174], 'affinity': [947, 961], 'binding': [948, 962, 994, 1006, 2334, 4339, 4355], '(K': [949, 963, 1248], 'D': [950, 964], '=': [951, 965, 1250], '107': [952], 'nm)': [953, 2924, 4289], 'with': [954, 968, 1253, 1268, 1415, 1585, 1668, 1672, 1740, 1813, 1922, 1972, 2163, 2272, 2436, 2679, 2710, 2724, 2902, 3221, 3290, 3307, 3441, 3474, 3640, 3705, 3990, 4083, 4443, 4530, 4537, 4548], '1:1': [956, 1254], '(zinc:Aβ)': [957], 'stoichiometry': [958, 971], '5.2': [966], 'μm)': [967, 2691, 3454, 3490, 3581, 4296, 4479, 4483], '2:1': [970], '(16Bush': [972, 1119, 1744, 3999], 'A.I.': [973, 1120, 1159, 1205, 1339, 1382, 1745, 1766, 1794, 2033, 3539, 4000, 4365], 'Pettingell': [974, 1121, 1160, 1340, 1383, 1746, 1767, 2034, 3540, 4001], 'Jr.,': [975, 1122, 1161, 1341, 1384, 1747, 1768, 2035, 2537, 2833, 2853, 2869, 2891, 3541, 4002, 4213, 4233, 4249, 4271], 'W.H.': [976, 1123, 1162, 1342, 1385, 1748, 1769, 2036, 3542, 4003], 'Paradis': [977, 1124, 1165, 1345, 1388, 1749, 1772, 2039, 3545, 4004], 'Tanzi': [979, 1126, 1175, 1210, 1355, 1398, 1751, 1782, 1799, 2049, 3555, 4006], 'R.E.': [980, 1127, 1176, 1211, 1356, 1399, 1752, 1783, 1800, 2050, 3556, 4007], '1994;': [984, 1131, 1178, 1358, 1401, 1756, 1785, 2052, 3558, 3690, 3955, 4011], '269:': [985, 1132, 1757, 3691, 4012], '12152-12158Abstract': [986, 1133, 1758, 4013], 'This': [993, 1842, 1986, 2095], 'histidine-mediated': [997], 'since': [998, 1410, 1924, 2098], 'acidic': [1003], '(no': [1005], 'at': [1007, 1201, 1237, 1261, 1670, 2400, 2468, 2504, 2712, 2717, 2784, 2804, 2909, 3001, 3009, 3045, 3086, 3141, 3171, 3203, 3256, 3393, 3631, 4093, 4329, 4342], '6).': [1009], 'zinc-binding': [1011, 1031, 4396], 'site': [1012], 'mapped': [1014], 'stretch': [1017], 'contiguous': [1019], 'residues': [1020, 4360], 'between': [1021, 1556, 2122, 2222, 4022], 'positions': [1022, 1238], '6–28': [1023], 'sequence.': [1027], 'Occupation': [1028], 'site,': [1032], 'straddles': [1034], 'lysine': [1036], '16': [1037], 'position': [1038], 'α-secretase': [1040, 1087], 'cleavage': [1041], '(17Esch': [1042], 'F.S.': [1043], 'Keim': [1044], 'P.S.': [1045], 'Beattie': [1046], 'E.C.': [1047], 'Blacher': [1048], 'R.W.': [1049], 'Culwell': [1050], 'Oltersdorf': [1052], 'T.': [1053], 'McClure': [1054], 'Ward': [1056], 'P.J.': [1057], '248:': [1060, 1079], '1122-1124Crossref': [1061], '(1215)': [1064], '18Sisodia': [1067], 'S.S.': [1068], 'Unterbeck': [1073], 'Price': [1075], 'D.L.': [1076], '492-495Crossref': [1080], '(749)': [1083], 'Scholar),': [1085, 1408, 1493, 1614, 2152, 2553, 3698, 4393], 'inhibits': [1086], 'type': [1088], '(tryptic)': [1089], 'cleavage,': [1090], 'so': [1092], 'may': [1093, 1105, 1562, 1916, 2216, 2266, 2276, 3873, 4053, 4111], 'influence': [1094, 2158, 2283], 'generation': [1096], 'from': [1099, 1116, 2092, 2793, 3252, 3587, 3856], 'protein': [1101, 2341, 2631, 3522], 'precursor': [1102], '(APP)': [1103], 'increase': [1106, 4453], 'biological': [1108], 'half-life': [1109], 'protecting': [1113], 'proteolytic': [1117], 'attack': [1118], 'also': [1141, 1513, 2257], '≥1': [1147], 'μm': [1148, 1624, 1728, 1952, 2470, 2567, 2972, 2984, 3021, 3025, 3124, 3440, 3473, 4416, 4527, 4539, 4552], 'destabilize': [1150], 'human': [1151, 1333, 1434], 'solutions,': [1153], 'inducing': [1154], 'rapid': [1155], '(19Bush': [1158, 1338, 1381, 2032, 3538], 'M.D.': [1166, 1346, 1389, 1773, 2040, 3546], 'Vonsattel': [1167, 1347, 1390, 1774, 2041, 3547], 'J.-P.': [1168, 1348, 1391, 1775, 2042, 3548], 'Gusella': [1169, 1349, 1392, 1776, 2043, 3549], 'J.F.': [1170, 1350, 1393, 1777, 2044, 3550], 'Masters': [1173, 1353, 1396, 1780, 2047, 3553, 3666, 4380], '265:': [1179, 1359, 1402, 1786, 2053, 3559], '1464-1467Crossref': [1180, 1360, 1403, 1787, 2054, 3560], '(1435)': [1183, 1363, 1406, 1790, 2057, 3563], 'Scholar)': [1185, 1719, 1809, 1915, 2059, 2901, 4509], 'although': [1192, 2173], 'both': [1193], 'copper(II)': [1194], 'iron(II)': [1196], 'induce': [1198, 1729, 1957, 2019, 4166], 'partial': [1199], 'equivalent': [1202, 4300], '(20Bush': [1204], 'Moir': [1206, 1795, 4368], 'R.D.': [1207, 1796, 4369], 'Rosenkranz': [1208, 1797], 'K.M.': [1209, 1798], '268:': [1214, 1803, 4386], '1921-1923Crossref': [1215, 1804], '(32)': [1218, 1807], 'Meanwhile,': [1221], 'rat': [1222, 1330, 1420], '(with': [1224], 'substitutions': [1225], 'Arg': [1227, 1236], '→': [1228, 1231, 1235], 'Gly,': [1229], 'Tyr': [1230], 'Phe,': [1232], 'His': [1234], '5,': [1239], '10,': [1240, 3451, 3487], '13,': [1242], 'respectively)': [1243], 'less': [1246, 1621], 'avidly': [1247], '3.8': [1251], 'μm,': [1252, 1864], 'stoichiometry)': [1255], 'unaffected': [1258], 'these': [1262, 1270, 1653, 2374, 2648, 3870], 'concentrations,': [1263], 'perhaps': [1264], 'explaining': [1265], 'scarcity': [1267], 'animals': [1271], 'form': [1272], '(21Johnstone': [1276], 'E.M.': [1277], 'Chaney': [1278], 'M.O.': [1279], 'Norris': [1280], 'F.H.': [1281], 'Pascual': [1282], 'Little': [1284], 'S.P.': [1285], 'Mol.': [1288, 3671, 3916], '10:': [1292], '299-305Crossref': [1293], '(305)': [1296], '22Shivers': [1299], 'B.D.': [1300], 'Hilbich': [1301], 'Salbaum': [1305], 'Seeburg': [1309], 'P.H.': [1310], 'EMBO': [1311], '1988;': [1313], '7:': [1314], '1365-1370Crossref': [1315], '(402)': [1318], 'absence': [1323, 3743], 'solubilities': [1327], 'species': [1335, 3800], 'are': [1336, 1438, 1452, 1461, 1625, 1999, 2610, 3702, 4099], 'indistinguishable': [1337], 'observed': [1367, 3978], 'iodinating': [1369], 'on': [1372, 1990, 2408, 2514, 3330, 3373, 3594], '10th': [1374], 'residue': [1375, 1412], 'tyrosine': [1377, 1426], 'attenuated': [1378], 'this': [1411, 1425, 1871, 4097, 4327, 4449], 'substituted': [1414], 'phenylalanine': [1417], 'species,': [1421], 'we': [1422, 1511, 2153, 3746, 3784, 3811, 3977, 4041, 4177], 'concluded': [1423], 'coordinating': [1430], 'peptide.': [1435, 1633, 2114, 3839], 'These': [1436, 2214, 2274, 3206], 'observations': [1437], 'important': [1439, 1845, 2097], 'because': [1440, 4186], 'same': [1446, 4427], 'neocortical': [1447, 1507], 'regions': [1448], 'commonly': [1454], 'found,': [1455], 'micromolar': [1458, 1995, 2081, 2192, 4175], 'achieved': [1462], 'during': [1463, 1966, 2012], 'glutamatergic': [1464, 2013], 'neurotransmission': [1465, 1967, 2014], '(24Assaf': [1466, 1888], 'S.Y.': [1467, 1889], 'Chung': [1468, 1890], 'S.-H.': [1469, 1891], '308:': [1472, 1487, 1894, 1909], '734-736Crossref': [1473, 1895], '(1046)': [1476, 1898], '25Howell': [1479, 1901], 'G.A.': [1480, 1902], 'Welch': [1481, 1903], 'Frederickson': [1483, 1905], '736-738Crossref': [1488, 1910], '(713)': [1491, 1913], 'an': [1495, 1551, 2024, 2814, 3102, 3632, 3985], 'explanation': [1496], 'propensity': [1499], 'close': [1504], 'synaptic': [1508, 1886, 1975], 'vicinity.': [1509], 'Recently,': [1510], 'mediates': [1518], 'significant': [1523, 3834, 4118], 'fraction': [1524], 'Alzheimer-affected': [1529], 'postmortem': [1530], 'tissue.': [1532], '1R.': [1533], 'Cherny,': [1535], 'Beyreuther,': [1537], 'E.': [1539], 'Tanzi,': [1540], 'L.': [1542], 'Masters,': [1543], 'Bush,': [1547], 'personal': [1548], 'communication.': [1549], 'Hence,': [1550], 'elaboration': [1552], 'interactions': [1555], 'germane': [1564], 'pathology': [1567], 'concentration': [1572, 1852, 3634, 3828, 4161], 'required': [1575, 1626, 1855, 1955, 2000, 2017, 4164], 'precipitate': [1577, 1857, 2002], 'has': [1581, 4194, 4349], 'been': [1582, 3875, 4195], 'disagreement': [1584, 1812], 'results': [1586, 3872], 'Esler': [1590, 1817, 2128, 2230], 'et': [1591, 1698, 1818, 2129, 2231, 2526], 'al.': [1592, 1699, 1819, 2130, 2232, 2527, 4487], '(26Esler': [1593, 1675, 1820, 2131, 2233, 4488], 'W.P.': [1594, 1676, 1821, 2132, 2234, 4489], 'Stimson': [1595, 1677, 1822, 2133, 2235, 4490], 'E.R.': [1596, 1678, 1823, 2134, 2236, 4491], 'Jennings': [1597, 1679, 1824, 2135, 2237, 4492], 'J.M.': [1598, 1680, 1825, 2136, 2238, 4493], 'Ghilardi': [1599, 1681, 1826, 2137, 2239, 4494], 'J.R.': [1600, 1682, 1827, 2138, 2240, 4495], 'Mantyh': [1601, 1683, 1828, 2139, 2241, 4496], 'P.W.': [1602, 1684, 1829, 2140, 2242, 4497], 'Maggio': [1603, 1685, 1830, 2141, 2243, 4498], 'J.E.': [1604, 1686, 1831, 2142, 2244, 4499], '66:': [1608, 1690, 1835, 2146, 2248, 4503], '723-732Crossref': [1609, 1691, 1836, 2147, 2249, 4504], '(126)': [1612, 1694, 1839, 2150, 2252, 4507], 'who': [1615, 1655], 'claimed': [1617], 'no': [1620, 2396, 4512], 'than': [1622], '100': [1623, 1727, 1863], 'demonstrate': [1628, 4116], 'appreciable': [1629], 'particular,': [1635], 'validity': [1637, 2635], 'filtration': [1640, 2609], 'assay': [1641, 2632, 2639, 2815, 3523, 3533], 'used': [1645, 2167, 2303, 2315, 2372, 2424, 2496, 3865, 4196, 4308, 4447], 'our': [1647, 1673, 1741, 2030, 2075, 2123, 2223, 3536, 3700, 3969, 4023, 4124], 'previous': [1648, 3970, 4028], 'study': [1649, 3814, 3971, 4071, 4098, 4144, 4198, 4450, 4472], 'challenged': [1651], 'workers': [1654], 'contended': [1656], 'that125I-Aβ1–40': [1657], 'suitable': [1660], 'tracer': [1661, 2068], 'monitoring': [1663, 2178], 'variance': [1671, 2121, 2219], 'findings': [1674, 1815, 2031, 2124, 2225, 2256], 'Rodriguez': [1697], '(27.J.': [1700, 3720], '272,': [1703, 1717, 3723, 3737], '21037–21044Garzon-Rodriguez,': [1704, 3724], 'W.,': [1705, 3725], 'Sepulveda-Becerra,': [1706, 3726], 'M.,': [1707, 3727], 'Milton,': [1708, 3728], 'S.,': [1709, 3729], 'Glabe,': [1711, 3731], 'Chem.,': [1716, 3736], '21037–21044.Google': [1718, 3738], 'below': [1726], 'immediate': [1733], 'Aβ1–40,': [1737, 2165], 'agreement': [1739, 3704], 'initial': [1742], 'reports': [1743], '19Bush': [1765], '20Bush': [1793], 'debate': [1843], 'two': [1847, 4036], 'reasons.': [1848], 'First,': [1849, 4040], 'if': [1850, 1974], 'is,': [1859], 'fact,': [1861], 'very': [1868], 'unlikely': [1869], 'any': [1875, 2618], 'neurobiological': [1876, 2280], 'significance.': [1877], 'Much': [1878], 'released': [1884, 1965, 2011], 'transmission': [1887], 'available': [1919], 'exchange': [1921, 1971], 'will': [1926], 'large': [1928], 'part': [1929], 'sequestered': [1931], 'macromolecules': [1933], 'other': [1935, 1992, 2429, 2501], 'ligands': [1936], '(28Frederickson': [1937], 'Int.': [1939], 'Rev.': [1940], 'Neurobiol.': [1941], '1989;': [1942], '31:': [1943, 2857, 4237], '145-328Crossref': [1944], '(981)': [1947], 'If': [1950], '>100': [1951], 'precipitation,': [1959], 'majority': [1961], 'would': [1968, 2015], 'need': [1969], 'factor': [1981], 'accumulation.': [1985], 'unlikely.': [1988], 'If,': [1989], 'hand,': [1993], 'only': [2005, 4072], '≈1%': [2006], 'total': [2009, 2754, 4136], 'making': [2022], 'far': [2026], 'more': [2027], 'likely.': [2028], 'Second,': [2029, 4067], 'questioned': [2060], 'use': [2062, 3423], '125I-Aβ': [2064], 'valid': [2067], 'unmodified': [2070, 2093], 'behavior,': [2072], 'hands,': [2076], 'effect': [2078], 'differentiated': [2088], 'iodinated': [2090], 'Aβ.': [2094], 'radiolabeling': [2099], 'iodination': [2103], 'common': [2106], 'means': [2107], 'creating': [2109], 'marker': [2111], 'To': [2115, 3012, 3110, 3225, 3566, 4157], 'explore': [2116], 'reasons': [2118], 'those': [2126], 'studied': [2154, 4178], 'physicochemical': [2155], 'factors': [2156, 2200, 2215, 2281], 'turbidometry': [2168], 'specific,': [2172], 'relatively': [2174], 'insensitive,': [2175], 'method': [2176, 4192], 'aggregation.': [2180, 3409, 4515], 'report': [2183, 2228, 3708], 'striking': [2186], 'sensitive': [2197], 'complex': [2199], 'buffer': [2203, 2993, 3433, 4105], 'impact': [2206], 'polymerization': [2212], 'state.': [2213, 3647], 'explain': [2217], 'exist': [2221], 'earlier': [2224, 4088, 4125], 'Our': [2255], 'conformational': [2261, 3835], 'state': [2262, 3229, 4201], 'perturbed': [2269], 'zinc.': [2273, 4468], 'data': [2275, 3701, 3790], 'provide': [2277], 'insights': [2278], 'solubility': [2285], 'pathophysiological': [2290], 'environment': [2291], 'Human': [2298], 'all': [2305, 2498, 2962], 'experiments,': [2306, 2966, 3239], 'synthesized,': [2307], 'purified,': [2308], 'characterized': [2310], 'HPLC': [2312, 2364], '2The': [2313], 'abbreviations': [2314], 'are:': [2316], 'HPLC,': [2317], 'performance': [2319], 'liquid': [2320], 'chromatography;': [2321], 'TBS,': [2322, 4418], 'Tris-buffered': [2323], 'saline;': [2324], 'MES,': [2325], '4-morpholineethanesulfonic': [2326], 'acid;': [2327, 2338], 'TFE,': [2328, 3482], 'trifluoroethanol;': [2329], 'HFIP,': [2330], '1,1,1,3,3,3-hexafluoro-2-propanol;': [2331], 'ZBD,': [2332], 'domain;': [2335], 'MOPS,': [2336], '4-morpholinepropanesulfonic': [2337], 'APP,': [2339, 4347], 'precursor.': [2342], 'analysis,': [2343], 'amino': [2344, 2401, 2653, 4344], 'analysis': [2346, 2387, 3337], 'mass': [2348, 2728], 'spectroscopy': [2349, 2405], 'W.': [2351], 'Keck': [2353], 'Foundation': [2354], 'Biotechnology': [2355], 'Resource': [2356], 'Laboratory': [2357], '(Yale': [2358], 'University,': [2359], 'New': [2360], 'Haven,': [2361], 'CT).': [2362], 'elution': [2365, 2765, 2780, 3751], 'profile': [2366, 3752], 'preparations': [2371], 'experiments': [2375], 'identified': [2377], 'sole': [2380], 'peak': [2381, 2781, 3620], 'eluate.': [2384], 'Amino': [2385], 'indicated': [2392], 'there': [2394], 'apparent': [2397, 3771, 3986, 3992], 'chemical': [2398], 'modifications': [2399], 'residues.': [2403], 'Mass': [2404], 'performed': [2407, 2658, 2819, 2908], 'each': [2409, 3326], 'batch': [2410], 'further': [2415, 3081, 3198, 3226], 'confirmation.': [2416], 'Milli-Q': [2417], 'water': [2418, 2563, 2583, 3390], '(Millipore': [2419, 2664], 'Corp.,': [2420], 'Milford,': [2421, 2666], 'MA)': [2422, 2667], 'solubilization': [2427], 'reagent': [2431], 'dilution.': [2432], 'Buffers': [2433], 'treated': [2435], 'Chelex-100': [2437], 'resin': [2438], '(Bio-Rad)': [2439], 'minimize': [2441], 'trace': [2442, 2619], 'metal': [2443], 'contamination,': [2444], 'filtered': [2446, 2593, 3502], 'through': [2447, 2581, 2594, 3503], '0.22-μm': [2449, 3505], 'cellulose': [2450, 2598, 3506], 'acetate': [2451, 2599, 3507], 'filter': [2452, 2600], 'unit': [2453, 2601], '(Corning': [2454, 2918], 'Costar': [2455, 2605, 2919], 'Corporation,': [2456, 2665], 'Cambridge,': [2457], 'MA).': [2458], 'background': [2460, 3146, 4410, 4557], 'buffers': [2465, 4307], 'measured': [2467, 2926, 3272], '<0.1': [2469], 'ion-coupled': [2472], 'plasma-atomic': [2473], 'emission': [2474], 'spectroscopy.': [2475], 'Standard': [2476], '(10': [2480, 4295, 4415, 4478], 'mg/ml': [2481], '10%': [2483], 'HCl,': [2484], 'National': [2487], 'Institute': [2488], 'Standards': [2490], 'Technology,': [2492], 'Gaithersburg,': [2493], 'MD)': [2494], 'experiments.': [2499, 4408], 'All': [2500, 3410], 'reagents': [2502], 'least': [2505], 'analytical': [2506], 'grade.': [2507], 'Synthetic': [2508], 'solutions': [2511, 2649, 3342, 3412, 3430, 4442], 'prepared': [2513, 3348, 3584, 4293], 'day': [2516, 3375, 3596], 'experiment': [2519], 'according': [2520, 2820, 3525], 'protocol': [2523], 'Evans': [2525], '(29Evans': [2528, 2824, 4204], 'K.C.': [2529, 2825, 4205], 'Berger': [2530, 2826, 2888, 4206, 4268], 'E.P.': [2531, 2827, 2889, 4207, 4269], 'Cho': [2532, 2828, 4208], 'C.-G.': [2533, 2829, 4209], 'Weisgraber': [2534, 2830, 4210], 'K.H.': [2535, 2831, 4211], 'Lansbury': [2536, 2832, 2852, 2868, 2890, 4212, 4232, 4248, 4270], 'P.T.': [2538, 2834, 2854, 2870, 2892, 4214, 4234, 4250, 4272], '92:': [2547, 2843, 4223], '763-767Crossref': [2548, 2844, 4224], '(345)': [2551, 2847, 4227], 'except': [2554], 'indicated.': [2556], 'Lyophilized': [2557], 'first': [2560, 4283], 'reach': [2565], '500': [2566], 'indirectly': [2570], 'sonicated': [2571], '3': [2573], 'min': [2574, 3105], '(30': [2575, 3457, 3493], 's': [2576, 2579], 'on,': [2577], '10': [2578, 2971, 3058, 3062, 4526, 4538, 4551], 'off)': [2580], 'bath': [2584], 'avoid': [2586], 'frothing.': [2587], 'preparation': [2590, 3896, 4047], 'water-washed': [2596], 'Spin-X': [2597], '(0.22': [2602, 2770], 'μ,': [2603], 'Corning': [2604], 'Corporation).': [2606, 2941], 'Sonication': [2607], 'considered': [2611], 'procedures': [2615], 'remove': [2617, 3425], 'microparticulate': [2622], 'matter.': [2623], 'Concentrations': [2624], 'determined': [2628, 2763, 3518, 4284], 'BCA': [2630, 2638, 3283, 3521], '(Pierce).': [2633], 'measurement': [2642, 2812], 'confirmed': [2651], 'analysis.': [2655], 'Experiments': [2656], 'using': [2659, 2927, 3049, 3281, 3657], 'Waters': [2660], 'model': [2661], '650E': [2662], 'system': [2663, 3864, 4328], 'connected': [2668], 'column': [2671, 2708, 2721, 2761, 2795, 3608, 4081], '(Bio-Rad': [2672, 2730], 'Econo-Column,': [2673], '30': [2674, 2681, 3104, 3453, 3489], '×': [2675, 3262, 3416], '1.0': [2676], 'cm)': [2677], 'prepacked': [2678], 'Superdex': [2680], '(Pharmacia': [2682], 'Biotech': [2683], 'AB,': [2684], 'Uppsala,': [2685], 'Sweden).': [2686], '(0.5': [2688], 'ml,': [2689], '2.3': [2690, 3439, 3472], 'Tris-HCl-buffered': [2693], 'saline': [2694, 3719], '(TBS,': [2695], '20': [2696, 3316, 3355, 3419, 3445, 3478], 'mm': [2697, 2700, 2978, 2991, 2995, 3031, 3034, 3059, 3063, 3127, 3130, 3356, 3443, 3476, 3479], 'Tris,': [2698], '150': [2699, 2981, 3030, 3126, 3442, 3475], '7.4)': [2703, 4420], 'injected': [2705], 'preequilibrated': [2709], 'TBS': [2711, 3586, 4298, 4433], 'room': [2713, 2910, 3010], 'temperature': [2714, 2911], 'eluted': [2716, 3615], '0.5': [2718, 4532], 'ml/min.': [2719], 'calibrated': [2723], 'combined': [2725], 'gel-filtration': [2726, 3574, 3607, 3658, 3715, 3975], 'molecular': [2727, 3627, 3760], 'markers': [2729], 'Sigma),': [2732], 'vitamin': [2733], 'B12': [2734], '(1.35': [2735], 'kDa),': [2736, 2739, 2743, 2747, 2776], 'aprotinin': [2737], '(6.5': [2738], 'cytochrome': [2740], 'C': [2741, 3661], '(12.4': [2742], 'equine': [2744], 'myoglobin': [2745], '(17': [2746], 'carbonic': [2749], 'anhydrase': [2750], '(29': [2751], 'kDa).': [2752], 'volume': [2755, 2758], 'void': [2757], 'volumes': [2766], 'dichromate': [2768], 'anion': [2769], 'kDa)': [2771], 'blue': [2773], 'dextran': [2774], '(2000': [2775], 'respectively.': [2777], 'monitored': [2783, 3220], '214-nm': [2785], 'absorbance,': [2786], 'amount': [2789, 3511], 'eluting': [2792], 'estimated': [2797, 3633], 'calibrating': [2799], 'absorbance': [2801, 3005, 3138, 4091, 4106, 4110, 4287, 4303, 4411, 4521, 4544], '214': [2805, 4094], 'nm': [2806, 3143, 3637, 4095, 4358], 'against': [2807], 'known': [2808], 'concentrations.': [2810], 'Turbidity': [2811], 'established': [2822, 4191], 'protocols': [2823], '30Jarrett': [2850, 4230], 'J.T.': [2851, 2887, 4231, 4267], 'Biochemistry.': [2855, 2893, 4235, 4273], '12345-12352Crossref': [2858, 4238], '(281)': [2861, 4241], '31Come': [2864, 4244], 'J.H.': [2865, 4245], 'Fraser': [2866, 4246], 'P.E.': [2867, 4247], '90:': [2879, 4259], '5959-5963Crossref': [2880, 4260], '(362)': [2883, 4263], '32Jarrett': [2886, 4266], '32:': [2895, 4275], '4693-4697Crossref': [2896, 4276], '(1790)': [2899, 4279], 'minor': [2903, 3991], 'modifications.': [2904], 'reactions': [2906], 'flat-bottom': [2914], '96-well': [2915, 3051], 'microtiter': [2916], 'plate': [2917, 2944, 2951, 3052], 'Corporation),': [2920], 'absorbances': [2922], '(405': [2923, 4288], 'V': [2929], 'maxkinetic': [2930], 'microplate': [2931], 'reader': [2932, 2952], 'directed': [2933], 'Softmax': [2935], 'version': [2936], '2.32': [2937], 'software': [2938], '(Molecular': [2939], 'Devices': [2940], 'Automatic': [2942], '30-s': [2943], 'agitation': [2945], 'mode': [2946], 'selected': [2948], 'evenly': [2954], 'suspend': [2955], 'wells': [2960, 3073, 3184], 'before': [2961, 3004, 3106, 3277, 3312], 'readings.': [2963, 3109], 'brought': [2969, 3121, 3155, 3437, 3470], '(300': [2973, 3242], 'μl)': [2974, 3179, 3243, 3311, 3324], 'either': [2976, 3268, 3354], '50': [2977, 2990, 3033, 3129, 3291], 'HEPES': [2979, 3319], 'buffer,': [2980], 'mmNaCl,': [2982], '0–300': [2983], '7.4,': [2987, 3191, 3359, 3448, 3484], '±chelator,': [2988], 'MES': [2992], '(150': [2994], '5.5),': [2998], 'incubated': [3000, 3100, 3234, 3456, 3492], '37': [3002, 3459, 3495], '°C': [3003, 3395], 'measurements': [3006, 3042, 3168, 3200], 'taken': [3008, 3044, 3085, 3170, 3202], 'temperature.': [3011], 'investigate': [3013, 3111], 'reversibility': [3015, 3113, 3238], 'aggregation,': [3019, 3118], '25': [3020, 3024, 3123], 'mixed': [3028, 4529], 'HEPES,': [3035, 3131], '7.4': [3037, 3133], '(200': [3038, 3134], 'μl),': [3039, 3135, 3165], 'turbidity': [3041, 3095, 3167, 4325, 4412], 'four': [3046, 3082, 3172, 3199], '1-min': [3047, 3087, 3173, 3204], 'intervals': [3048], 'reader.': [3053], 'Subsequently,': [3054, 3175], '20-μl': [3055], 'aliquots': [3056], 'EDTA': [3060, 3092], '(prepared': [3065], 'incubation': [3067, 3254, 4439], 'buffer)': [3068], 'added': [3070, 3181], 'alternately,': [3074], 'following': [3076, 3193], '2-min': [3078, 3195], 'delay,': [3079, 3196], 'readings': [3083, 4092, 4522], 'intervals.': [3088, 3174, 3205], 'After': [3089], 'final': [3091, 3108], 'addition': [3093, 3160], 'reading,': [3096, 4107], 'mixtures': [3098, 3500], 'additional': [3103], 'taking': [3107], '5.5-induced': [3116], 'read': [3140], '405': [3142], 'reading.': [3147], '5.5': [3157], 'concentrated': [3162, 3176], 'HCl': [3163], '(5.5': [3164], 'NaOH': [3177], '(7.5': [3178], 'adjust': [3186], 'back': [3189], 'cycles': [3207], 'repeated': [3209], 'indicated,': [3211], 'mixture': [3217], 'constantly': [3219], 'probe.': [3224], 'determine': [3227, 3402], 'peptides': [3235, 3848], 'replicate': [3240], 'samples': [3241], 'representing': [3244, 4474], 'various': [3245, 3257], 'zinc-containing': [3246], 'chelated': [3248], 'removed': [3251], 'tray': [3255], 'points,': [3259], 'pelleted': [3260], '(10,000': [3261, 3415], 'g': [3263, 3417], '15': [3265], 'min),': [3266], 'supernatant': [3270], 'remaining': [3274], 'content': [3276], 'after': [3279], 'centrifugation': [3280], 'assay,': [3284], 'pellet': [3287], 'stained': [3289], 'μl': [3292, 3317], 'Congo': [3294], 'Red': [3295], '(1%': [3296], '50%': [3298, 3308], 'ethanol': [3299, 3309], '5': [3301, 4073, 4549], 'min).': [3302], 'Pellets': [3303], 'washed': [3305], 'twice': [3306], '(100': [3310], 'being': [3313, 3643], 'resuspended': [3314], 'buffer.': [3320], 'An': [3321], 'aliquot': [3322], '(3': [3323], 'resuspension': [3327], 'placed': [3329], 'microscope': [3332], 'slide': [3333], 'uniformly': [3334], 'microscopic': [3336], 'under': [3338, 3803], 'polarized': [3339], 'light.': [3340], 'Stock': [3341], '(0.2': [3345], 'mm)': [3346], 'dissolving': [3350], 'lyophilized': [3351, 3589], 'Tris-HCl,': [3357, 3480], '10–30%': [3361, 3467, 3481], 'trifluoroethanol': [3362], '(TFE),': [3363], '75%': [3365, 3385], 'dimethyl': [3366], 'sulfoxide': [3367], '(Me2SO),': [3368], '25%': [3369, 3387], '1,1,1,3,3,3-hexafluoro-2-propanol': [3370], '(HFIP)': [3371], '(v/v),': [3372], 'study.': [3378, 4089], 'Other': [3379, 3648], 'stocks': [3380], 'dissolved': [3383, 3465], 'Me2SO,': [3386], 'HFIP': [3388], '−20': [3394], 'up': [3397], '2': [3399], 'months': [3400], 'effects': [3404, 3836], 'storage': [3406], 'centrifuged': [3414], 'min)': [3420], 'prior': [3421], 'aggregates.': [3426], 'Tris': [3432], 'Me2SO/HFIP': [3435], 'mmTris-HCl,': [3446], '±zinc': [3449, 3485], '(0,': [3450, 3486], 'min,': [3458, 3494], '°C).': [3460, 3496], 'TFE': [3468], 'Following': [3497], 'incubation,': [3498], 'filter,': [3508], 'entering': [3514], 'filtrate': [3516], 'micro': [3520], '(Pierce),': [3524], 'modification': [3528], 'developed': [3534], 'group': [3537], 'characterize': [3567], 'neutral': [3571, 3717, 3822], 'buffered': [3572, 3718, 3823], 'saline,': [3573, 3824], 'chromatography': [3575, 3659], 'performed.': [3577], '(2.3': [3580], 'freshly': [3583, 4292], 'powder': [3590], '(see': [3591], '"Experimental': [3592], 'Procedures")': [3593], 'experiment.': [3599], 'loaded': [3604], 'onto': [3605], 'within': [3609], '1': [3610, 4534], 'h': [3611], 'preparation,': [3613], 'single': [3618], 'sharp': [3619], 'corresponding': [3621], '8.6': [3623], 'kDa': [3624], 'compared': [3625, 4082, 4536], 'size': [3628, 3761], 'markers,': [3629], '470': [3636], '(Fig.1),': [3638], 'compatible': [3639], 'dimeric': [3646, 3655, 3713, 4063], 'groups': [3649], '(33Hilbich': [3660], 'Kisters-Woike': [3662], 'Reed': [3664], '218:': [3674], '149-163Crossref': [3675], '(552)': [3678], '34Soreghan': [3681], '28551-28554Abstract': [3692], 'recent': [3707], 'predominantly': [3712], 'However,': [3740, 4542], 'became': [3753], 'too': [3754], 'broad': [3755], 'allow': [3757], 'relative': [3759], 'resolved': [3764], '(data': [3765, 4309, 4435], 'shown),': [3767, 4311, 4437], 'dimerization': [3772], 'NaCl.': [3782], 'Since': [3783], 'wished': [3785], 'achieve': [3787], 'basic': [3789], 'set': [3791], 'describes': [3793], 'behavior': [3795, 3816, 4180, 4403], 'approach': [3806], 'plausible': [3809], 'milieu,': [3810], 'proceeded': [3812, 4470], 'isotonic': [3821], 'mindful': [3825], 'NaCl': [3830], 'appears': [3831], 'enact': [3833], 'Some': [3840], 'chromatographic': [3844, 3868], 'profiles': [3845], 'appear': [3850], 'nondimeric': [3851], '(monomeric': [3852], 'oligomeric).': [3854], 'Apart': [3855], 'differences': [3857, 3878, 3893], 'composition': [3860], 'solvent': [3863], 'procedure,': [3869], 'alternative': [3871], 'due': [3876, 4034], 'behaviors': [3881], 'subspecies': [3885], 'studied,': [3891], 'variations': [3902], 'experimental': [3905, 4306], 'procedure': [3906], '(35Barrow': [3907], 'Yasuda': [3909], 'Kenny': [3911], 'P.T.M.': [3912], 'Zagorski': [3913], '225:': [3919], '1075-1093Crossref': [3920], '(621)': [3923], '36Shen': [3926], 'C.-L.': [3927, 3948], 'Scott': [3928], 'G.L.': [3929], 'Merchant': [3930], 'Murphy': [3932, 3951], 'R.M.': [3933, 3952], '65:': [3937], '2383-2395Abstract': [3938], '(87)': [3944], '37Shen': [3947], 'Fitzgerald': [3949], 'M.C.': [3950], '67:': [3956], '1238-1246Abstract': [3957], '(76)': [3963], 'For': [3966], 'example,': [3967], 'chromatography,': [3976], 'migrated': [3982], 'mainly': [3983], '(65%)': [3988], 'together': [3989], 'polymer': [3993, 4061], '(30%)': [3994], 'monomer': [3996], '(5%)': [3997], 'peaks': [3998], 'difference': [4021], 'current': [4024, 4070, 4143], 'result': [4025, 4029], 'explained': [4032], 'newly': [4037], 'introduced': [4038, 4043], 'variables.': [4039], 'sonication': [4044], 'solution,': [4051], 'contributed': [4055], 'dissolution': [4058], 'monomeric': [4065, 4119, 4152], 'species.': [4066], 'μg': [4074, 4085], 'applied': [4078], '55': [4084], 'Therefore,': [4090, 4140], 'much': [4100], 'closer': [4101], 'base-line': [4104], 'sufficient': [4114], 'peak,': [4120], 'since,': [4121], 'based': [4122], 'data,': [4126], 'expected': [4130], 'small': [4133, 4149], 'eluent.': [4139], 'cannot': [4154], 'excluded.': [4156], 'confirm': [4158], 'whether': [4159], 'range,': [4176], 'turbidometry,': [4185], 'well': [4190], 'value': [4290], 'does': [4321, 4461], 'contribute': [4323], 'frame': [4332], 'studied.': [4333], 'chose': [4335], 'minimal': [4337], 'domain': [4340], '(ZBD)': [4341], 'terminus': [4345], 'K': [4351], '≈750': [4357], '(ZBD,': [4359], '179–189': [4361], 'APP)': [4363], '(38Bush': [4364], 'Williamson': [4370], 'T.G.': [4371], 'Small': [4372], 'Rumble': [4374], 'Pollwein': [4376], '16109-16112Abstract': [4387], 'control': [4397], 'comparison': [4400], 'ZBD': [4414, 4441, 4459], 'alone': [4434], 'did': [4451], 'their': [4454], 'turbidity,': [4455], 'aggregate': [4463], '(<100': [4482], 'Esleret': [4486], 'find': [4511], 'There': [4516], 'negligible': [4518], 'changes': [4519], '0.1,': [4531], 'μmzinc,': [4535], 'alone.': [4541], 'increases': [4545], 'substantially': [4555], 'above': [4556], '(Fig.2': [4558], 'A),': [4559], 'corroborat': [4560]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2063281989', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 12}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-08T19:02:28.728712', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
