Publication Information

{'id': 'https://openalex.org/W2063137955', 'doi': 'https://doi.org/10.1074/jbc.m501702200', 'title': 'Transactivation-dependent and -independent Regulation of p73 Stability', 'display_name': 'Transactivation-dependent and -independent Regulation of p73 Stability', 'publication_year': 2005, 'publication_date': '2005-05-27', 'ids': {'openalex': 'https://openalex.org/W2063137955', 'doi': 'https://doi.org/10.1074/jbc.m501702200', 'mag': '2063137955', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15919663'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m501702200', 'pdf_url': 'http://www.jbc.org/article/S0021925820565162/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820565162/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5022370516', 'display_name': 'Iqbal Dulloo', 'orcid': 'https://orcid.org/0000-0001-6899-8338'}, 'institutions': [{'id': 'https://openalex.org/I4210137145', 'display_name': 'National Cancer Centre Singapore', 'ror': 'https://ror.org/03bqk3e80', 'country_code': 'SG', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137145']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Iqbal Dulloo', 'raw_affiliation_strings': ['Laboratory of Molecular Carcinogenesis, Division of Cellular and Molecular Research, National Cancer Centre, 11 Hospital Drive, Singapore 169610 and the'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular Carcinogenesis, Division of Cellular and Molecular Research, National Cancer Centre, 11 Hospital Drive, Singapore 169610 and the', 'institution_ids': ['https://openalex.org/I4210137145']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5066866150', 'display_name': 'Kanaga Sabapathy', 'orcid': 'https://orcid.org/0000-0002-4346-7386'}, 'institutions': [{'id': 'https://openalex.org/I4210137145', 'display_name': 'National Cancer Centre Singapore', 'ror': 'https://ror.org/03bqk3e80', 'country_code': 'SG', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137145']}, {'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}], 'countries': ['SG'], 'is_corresponding': True, 'raw_author_name': 'Kanaga Sabapathy', 'raw_affiliation_strings': ['Department of Biochemistry, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore', 'Laboratory of Molecular Carcinogenesis, Division of Cellular and Molecular Research, National Cancer Centre, 11 Hospital Drive, Singapore 169610 and the'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular Carcinogenesis, Division of Cellular and Molecular Research, National Cancer Centre, 11 Hospital Drive, Singapore 169610 and the', 'institution_ids': ['https://openalex.org/I4210137145']}, {'raw_affiliation_string': 'Department of Biochemistry, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore', 'institution_ids': ['https://openalex.org/I165932596']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5066866150'], 'corresponding_institution_ids': ['https://openalex.org/I4210137145', 'https://openalex.org/I165932596'], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 1.212, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 21, 'citation_normalized_percentile': {'value': 0.749483, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '280', 'issue': '31', 'first_page': '28203', 'last_page': '28214'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12996', 'display_name': 'Cancer Research and Treatments', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.9826, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C1292079', 'wikidata': 'https://www.wikidata.org/wiki/Q3817769', 'display_name': 'Transactivation', 'level': 4, 'score': 0.99385214}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.6782}, {'id': 'https://openalex.org/C179185449', 'wikidata': 'https://www.wikidata.org/wiki/Q219699', 'display_name': 'Suppressor', 'level': 3, 'score': 0.67344505}, {'id': 'https://openalex.org/C2776192174', 'wikidata': 'https://www.wikidata.org/wiki/Q18028978', 'display_name': 'Mdm2', 'level': 3, 'score': 0.5426143}, {'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.52229047}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4968188}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4169047}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.41414526}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.37541395}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.28847027}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.2795791}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.1979259}], 'mesh': [{'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003001', 'descriptor_name': 'Cloning, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003513', 'descriptor_name': 'Cycloheximide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003513', 'descriptor_name': 'Cycloheximide', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D017931', 'descriptor_name': 'DNA Primers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017930', 'descriptor_name': 'Genes, Reporter', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016147', 'descriptor_name': 'Genes, Tumor Suppressor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016147', 'descriptor_name': 'Genes, Tumor Suppressor', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006706', 'descriptor_name': 'Homeostasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008156', 'descriptor_name': 'Luciferases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008156', 'descriptor_name': 'Luciferases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008156', 'descriptor_name': 'Luciferases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017384', 'descriptor_name': 'Sequence Deletion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015533', 'descriptor_name': 'Transcriptional Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072160', 'descriptor_name': 'Tumor Protein p73', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025521', 'descriptor_name': 'Tumor Suppressor Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m501702200', 'pdf_url': 'http://www.jbc.org/article/S0021925820565162/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15919663', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m501702200', 'pdf_url': 'http://www.jbc.org/article/S0021925820565162/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.43, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 49, 'referenced_works': ['https://openalex.org/W1487724525', 'https://openalex.org/W1520122908', 'https://openalex.org/W1531240647', 'https://openalex.org/W1555846481', 'https://openalex.org/W1556144459', 'https://openalex.org/W1675096266', 'https://openalex.org/W1966292443', 'https://openalex.org/W1976776826', 'https://openalex.org/W1978354309', 'https://openalex.org/W1978856493', 'https://openalex.org/W1982121839', 'https://openalex.org/W1987276892', 'https://openalex.org/W1997222931', 'https://openalex.org/W1998559412', 'https://openalex.org/W2006313701', 'https://openalex.org/W2014162746', 'https://openalex.org/W2019109254', 'https://openalex.org/W2020954198', 'https://openalex.org/W2042042897', 'https://openalex.org/W2056530510', 'https://openalex.org/W2060251266', 'https://openalex.org/W2060972565', 'https://openalex.org/W2061932825', 'https://openalex.org/W2067186547', 'https://openalex.org/W2068564200', 'https://openalex.org/W2073286776', 'https://openalex.org/W2073491051', 'https://openalex.org/W2073658485', 'https://openalex.org/W2078189636', 'https://openalex.org/W2078242867', 'https://openalex.org/W2082979850', 'https://openalex.org/W2083620083', 'https://openalex.org/W2084499174', 'https://openalex.org/W2086332776', 'https://openalex.org/W2088010622', 'https://openalex.org/W2106031335', 'https://openalex.org/W2106402455', 'https://openalex.org/W2109733075', 'https://openalex.org/W2114083241', 'https://openalex.org/W2122976298', 'https://openalex.org/W2126787895', 'https://openalex.org/W2139986038', 'https://openalex.org/W2140279459', 'https://openalex.org/W2146035452', 'https://openalex.org/W2164712283', 'https://openalex.org/W2165454946', 'https://openalex.org/W2323729123', 'https://openalex.org/W2336498212', 'https://openalex.org/W2340120319'], 'related_works': ['https://openalex.org/W30444622', 'https://openalex.org/W2900615434', 'https://openalex.org/W2360453758', 'https://openalex.org/W2125124408', 'https://openalex.org/W2113761414', 'https://openalex.org/W2102368462', 'https://openalex.org/W2036239925', 'https://openalex.org/W2007249806', 'https://openalex.org/W1927421238', 'https://openalex.org/W1510940290'], 'abstract_inverted_index': {'The': [0], 'tumor': [1], 'suppressor': [2], 'p53': [3, 17], 'regulates': [4], 'its': [5, 52, 98, 175], 'own': [6, 99], 'stability': [7, 31], 'by': [8, 130, 142], 'transcriptionally': [9], 'activating': [10], 'Mdm2,': [11], 'Pirh2,': [12], 'and': [13, 36, 159, 167, 188, 199, 217], 'COP1,': [14], 'which': [15], 'target': [16], 'for': [18, 76, 197, 200], 'degradation.': [19, 78, 202], 'However,': [20], 'whether': [21], 'such': [22], 'a': [23, 72, 119, 215], 'negative': [24, 73], 'feedback': [25, 74], 'mechanism': [26, 75], 'exists': [27], 'to': [28, 96], 'regulate': [29], 'the': [30, 34, 61, 69, 90, 110, 114, 136, 146, 149, 157, 171, 182, 194, 205, 222, 226], 'of': [32, 39, 63, 71, 105, 125, 151, 162, 174, 190, 225], 'p73,': [33], 'structural': [35], 'functional': [37], 'homologue': [38], 'p53,': [40, 44, 144], 'is': [41, 46, 54, 211], 'unclear.': [42], 'Unlike': [43], 'p73': [45, 64, 77, 79, 107, 131, 152, 163, 191, 209, 228], 'not': [47, 141], 'mutated': [48], 'in': [49, 118, 148, 156, 214, 221], 'cancers,': [50], 'but': [51, 140], 'expression': [53, 224], 'significantly': [55], 'elevated.': [56], 'Thus,': [57], 'we': [58, 179], 'have': [59, 180], 'investigated': [60], 'regulation': [62, 150], 'turnover.': [65], 'Our': [66], 'data': [67, 206], 'suggest': [68, 207], 'existence': [70], 'mutants': [80, 132], 'with': [81], 'compromised': [82], 'transactivation': [83, 116, 137, 176], 'activity': [84, 138], 'are': [85], 'generally': [86], 'more': [87], 'stable': [88], 'than': [89], 'full-length': [91], 'TAp73': [92, 94, 126, 139], 'form.': [93], 'appears': [95], 'promote': [97], 'turnover': [100, 210], 'as': [101, 103, 192], 'well': [102], 'that': [104, 112, 133, 208], 'other': [106], 'forms,': [108], 'including': [109], 'DeltaNp73': [111], 'lacks': [113], 'amino-terminal': [115], 'domain,': [117], 'transactivation-dependent': [120, 216], 'manner.': [121], 'This': [122], 'degradation-inducing': [123], 'property': [124], 'was': [127], 'inhibited': [128], 'only': [129], 'also': [134], 'inhibit': [135], 'mutant': [143], 'highlighting': [145], 'specificity': [147], 'stability.': [153], 'Moreover,': [154], 'regions': [155, 183], 'amino': [158, 185], 'carboxyl': [160], 'termini': [161], 'confer': [164], 'both': [165], 'stabilizing': [166], 'destabilizing': [168], 'effects': [169], 'on': [170], 'protein,': [172], 'independent': [173], 'ability.': [177], 'Finally,': [178], 'identified': [181], 'between': [184], 'acids': [186], '56': [187], '248': [189], 'being': [193], 'region': [195], 'required': [196], 'p73-mediated': [198], 'ubiquitin-mediated': [201], 'Taken': [203], 'together,': [204], 'tightly': [212], 'regulated': [213], '-independent': [218], 'manner,': [219], 'resulting': [220], 'controlled': [223], 'various': [227], 'forms.': [229]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2063137955', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-22T06:02:25.534786', 'created_date': '2016-06-24'}