Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2063106182', 'doi': 'https://doi.org/10.1373/clinchem.2009.126870', 'title': 'The Search for New Prostate Cancer Biomarkers Continues', 'display_name': 'The Search for New Prostate Cancer Biomarkers Continues', 'publication_year': 2009, 'publication_date': '2009-05-29', 'ids': {'openalex': 'https://openalex.org/W2063106182', 'doi': 'https://doi.org/10.1373/clinchem.2009.126870', 'mag': '2063106182', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19478024'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1373/clinchem.2009.126870', 'pdf_url': 'https://academic.oup.com/clinchem/article-pdf/55/7/1277/32675678/clinchem1277.pdf', 'source': {'id': 'https://openalex.org/S139212996', 'display_name': 'Clinical Chemistry', 'issn_l': '0009-9147', 'issn': ['0009-9147', '1530-8561'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320272', 'host_organization_name': 'American Association for Clinical Chemistry', 'host_organization_lineage': ['https://openalex.org/P4310320272'], 'host_organization_lineage_names': ['American Association for Clinical Chemistry'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/clinchem/article-pdf/55/7/1277/32675678/clinchem1277.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5108482514', 'display_name': 'Maria Pavlou', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}, {'id': 'https://openalex.org/I1291836623', 'display_name': 'Mount Sinai Hospital', 'ror': 'https://ror.org/05deks119', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1291836623', 'https://openalex.org/I4210130843']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Maria Pavlou', 'raw_affiliation_strings': ['Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada', 'Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada; and'], 'affiliations': [{'raw_affiliation_string': 'Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}, {'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada; and', 'institution_ids': ['https://openalex.org/I1291836623']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5084226800', 'display_name': 'Eleftherios P. Diamandis', 'orcid': 'https://orcid.org/0000-0002-1589-820X'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}, {'id': 'https://openalex.org/I1291836623', 'display_name': 'Mount Sinai Hospital', 'ror': 'https://ror.org/05deks119', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1291836623', 'https://openalex.org/I4210130843']}, {'id': 'https://openalex.org/I1325899441', 'display_name': 'University Health Network', 'ror': 'https://ror.org/042xt5161', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325899441']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Eleftherios P Diamandis', 'raw_affiliation_strings': ['Department of Clinical Biochemistry, University Health Network, Toronto, ON, Canada', 'Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada', 'Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada; and'], 'affiliations': [{'raw_affiliation_string': 'Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}, {'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada; and', 'institution_ids': ['https://openalex.org/I1291836623']}, {'raw_affiliation_string': 'Department of Clinical Biochemistry, University Health Network, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I1325899441']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4088, 'currency': 'USD', 'value_usd': 4088, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.006, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 20, 'citation_normalized_percentile': {'value': 0.703419, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 88, 'max': 89}, 'biblio': {'volume': '55', 'issue': '7', 'first_page': '1277', 'last_page': '1279'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12465', 'display_name': 'Cancer, Lipids, and Metabolism', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12465', 'display_name': 'Cancer, Lipids, and Metabolism', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10836', 'display_name': 'Metabolomics and Mass Spectrometry Studies', 'score': 0.9963, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sarcosine', 'display_name': 'Sarcosine', 'score': 0.61003494}], 'concepts': [{'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.82776725}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6845744}, {'id': 'https://openalex.org/C2779943223', 'wikidata': 'https://www.wikidata.org/wiki/Q414157', 'display_name': 'Sarcosine', 'level': 4, 'score': 0.61003494}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.48490816}, {'id': 'https://openalex.org/C2781406297', 'wikidata': 'https://www.wikidata.org/wiki/Q409450', 'display_name': 'Prostate-specific antigen', 'level': 4, 'score': 0.44791117}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.42711085}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.42636406}, {'id': 'https://openalex.org/C2776235491', 'wikidata': 'https://www.wikidata.org/wiki/Q9625', 'display_name': 'Prostate', 'level': 3, 'score': 0.42183718}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.36710167}, {'id': 'https://openalex.org/C2777756961', 'wikidata': 'https://www.wikidata.org/wiki/Q620730', 'display_name': 'Glycine', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1373/clinchem.2009.126870', 'pdf_url': 'https://academic.oup.com/clinchem/article-pdf/55/7/1277/32675678/clinchem1277.pdf', 'source': {'id': 'https://openalex.org/S139212996', 'display_name': 'Clinical Chemistry', 'issn_l': '0009-9147', 'issn': ['0009-9147', '1530-8561'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320272', 'host_organization_name': 'American Association for Clinical Chemistry', 'host_organization_lineage': ['https://openalex.org/P4310320272'], 'host_organization_lineage_names': ['American Association for Clinical Chemistry'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19478024', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1373/clinchem.2009.126870', 'pdf_url': 'https://academic.oup.com/clinchem/article-pdf/55/7/1277/32675678/clinchem1277.pdf', 'source': {'id': 'https://openalex.org/S139212996', 'display_name': 'Clinical Chemistry', 'issn_l': '0009-9147', 'issn': ['0009-9147', '1530-8561'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320272', 'host_organization_name': 'American Association for Clinical Chemistry', 'host_organization_lineage': ['https://openalex.org/P4310320272'], 'host_organization_lineage_names': ['American Association for Clinical Chemistry'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.58, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 12, 'referenced_works': ['https://openalex.org/W1549690016', 'https://openalex.org/W2013036395', 'https://openalex.org/W2030121119', 'https://openalex.org/W2042475696', 'https://openalex.org/W2058596530', 'https://openalex.org/W2068601261', 'https://openalex.org/W2095761465', 'https://openalex.org/W2098442117', 'https://openalex.org/W2107579655', 'https://openalex.org/W2132528779', 'https://openalex.org/W2155680682', 'https://openalex.org/W2165681080'], 'related_works': ['https://openalex.org/W846826746', 'https://openalex.org/W4255120256', 'https://openalex.org/W2381163510', 'https://openalex.org/W2376423713', 'https://openalex.org/W2343768064', 'https://openalex.org/W2088520467', 'https://openalex.org/W2075763133', 'https://openalex.org/W2031954916', 'https://openalex.org/W1583600832', 'https://openalex.org/W1519781645'], 'abstract_inverted_index': {'Reports': [0], 'published': [1, 77], 'in': [2, 14, 64, 73, 99, 137, 172, 184, 188, 202, 262], 'top-ranked': [3], 'scientific': [4], 'journals': [5], 'frequently': [6, 134, 237], 'draw': [7], 'public': [8], 'media': [9], 'attention.': [10], 'A': [11], 'recent': [12], 'report': [13, 83, 98], 'Nature': [15], 'by': [16, 23, 156, 279, 294], 'a': [17, 39, 71, 112, 118, 142, 194], 'stellar': [18], 'group': [19], 'of': [20, 30, 42, 55, 109, 123, 128, 205, 235, 252], 'investigators,': [21], 'led': [22], 'Arul': [24], 'M.': [25], 'Chinnaiyan': [26], 'from': [27], 'the': [28, 61, 106, 126, 132, 147, 173, 216, 231, 236, 281], 'University': [29], 'Michigan,': [31], 'raises': [32], 'hopes': [33], 'that': [34, 67, 120, 149, 185, 197, 225, 245, 256, 278], 'their': [35, 65], 'discovery': [36], 'may': [37, 47, 69], 'provide': [38], 'better': [40], 'understanding': [41], 'prostate': [43, 56, 74, 114, 139, 253], 'cancer': [44, 57, 75, 115, 136, 140, 165, 177, 254], 'progression': [45], 'and': [46, 79, 90, 102, 211, 228, 255, 271], 'contribute': [48], 'to': [49, 125, 215], 'noninvasive': [50], 'detection': [51], 'or': [52], 'prognostic': [53, 91], 'evaluation': [54], '(1).': [58], 'Interestingly,': [59], 'although': [60], 'authors': [62], 'convey': [63], 'title': [66], 'sarcosine': [68, 110], 'play': [70], 'role': [72], 'progression,': [76], 'news': [78], 'commentaries': [80], 'on': [81, 87, 105], 'this': [82, 97, 164, 246], 'have': [84], 'focused': [85], 'more': [86], 'sarcosine’s': [88], 'diagnostic': [89], 'potential': [92, 107], '(2)(3).': [93], 'Here': [94], 'we': [95, 285], 'analyze': [96], 'some': [100, 200], 'detail': [101], 'comment': [103], 'primarily': [104], 'value': [108], 'as': [111, 267], 'urinary': [113], 'diagnostic/prognostic': [116], 'test,': [117, 284], 'topic': [119], 'should': [121], 'be': [122, 260], 'interest': [124], 'readers': [127], 'Clinical': [129], 'Chemistry': [130], '.\n\nBeing': [131], 'most': [133], 'diagnosed': [135], 'males,': [138], 'is': [141, 178, 193, 221, 274], 'major': [143], 'health': [144], 'problem.': [145], 'Despite': [146], 'fact': [148], 'its': [150], 'mortality': [151], 'rate': [152], 'has': [153], 'been': [154], 'decreasing': [155], 'about': [157], '4%': [158], 'per': [159], 'year': [160], 'since': [161], '1992': [162], '(4),': [163], 'still': [166], 'kills': [167, 230], '30': [168], '000': [169], 'men': [170, 206], 'annually': [171], 'US': [174], 'alone.': [175], 'Prostate': [176], 'rather': [179], 'unique': [180], 'among': [181], 'solid': [182], 'tumors': [183], 'it': [186], 'presents': [187], '2': [189], 'distinct': [190], 'forms.': [191], 'One': [192], 'latent': [195, 291], 'form': [196, 224], 'occurs': [198], 'at': [199], 'time': [201], 'almost': [203], 'half': [204], 'older': [207], 'than': [208], '60': [209], 'years': [210], 'poses': [212], 'no': [213], 'threat': [214], 'patient’s': [217], 'life.': [218], 'The': [219, 233], 'second': [220], 'an': [222], 'aggressive': [223], 'metastasizes': [226], 'quickly': [227], 'eventually': [229], 'patient.': [232], 'disadvantages': [234], 'used': [238], 'prostate-specific': [239], 'antigen': [240], '(PSA)': [241], 'serum': [242, 282], 'test': [243, 247], 'are': [244], 'detects': [248], 'indiscriminately': [249], 'both': [250], 'types': [251], 'PSA': [257, 283], 'can': [258], 'also': [259], 'increased': [261], 'nonmalignant': [263], 'prostatic': [264, 269], 'diseases,': [265], 'such': [266], 'benign': [268], 'hyperplasia': [270], 'prostatitis.': [272], 'It': [273], 'thus': [275], 'not': [276], 'surprising': [277], 'using': [280], 'end': [286], 'up': [287], 'with': [288, 296], 'overdiagnosis': [289], '(of': [290], 'forms)': [292], 'followed': [293], 'overtreatment,': [295], '…': [297]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2063106182', 'counts_by_year': [{'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-11T09:47:51.099759', 'created_date': '2016-06-24'}