Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2062904433', 'doi': 'https://doi.org/10.1016/j.mcn.2010.07.005', 'title': 'Megalin interacts with APP and the intracellular adapter protein FE65 in neurons', 'display_name': 'Megalin interacts with APP and the intracellular adapter protein FE65 in neurons', 'publication_year': 2010, 'publication_date': '2010-11-01', 'ids': {'openalex': 'https://openalex.org/W2062904433', 'doi': 'https://doi.org/10.1016/j.mcn.2010.07.005', 'mag': '2062904433', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20637285'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.mcn.2010.07.005', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47891569', 'display_name': 'Molecular and Cellular Neuroscience', 'issn_l': '1044-7431', 'issn': ['1044-7431', '1095-9327'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5073758402', 'display_name': 'Ximena Alvira', 'orcid': 'https://orcid.org/0000-0002-1688-5857'}, 'institutions': [{'id': 'https://openalex.org/I63634437', 'display_name': 'Autonomous University of Madrid', 'ror': 'https://ror.org/01cby8j38', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I63634437']}, {'id': 'https://openalex.org/I4210086614', 'display_name': 'Research Institute Hospital 12 de Octubre', 'ror': 'https://ror.org/002x1sg85', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210086614']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Ximena Alvira-Botero', 'raw_affiliation_strings': ['Department of Anatomy, Histology and Neuroscience, Universidad Autónoma de Madrid, C/Arzobispo Morcillo 4. 28029, Madrid, Spain', 'Laboratory of Neuroscience, Research Center, Hospital 12 de Octubre, Avenida de Córdoba s/n. 28041, Madrid, Spain'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomy, Histology and Neuroscience, Universidad Autónoma de Madrid, C/Arzobispo Morcillo 4. 28029, Madrid, Spain', 'institution_ids': ['https://openalex.org/I63634437']}, {'raw_affiliation_string': 'Laboratory of Neuroscience, Research Center, Hospital 12 de Octubre, Avenida de Córdoba s/n. 28041, Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210086614']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004741036', 'display_name': 'Rocío Pérez‐González', 'orcid': 'https://orcid.org/0000-0002-0641-2001'}, 'institutions': [{'id': 'https://openalex.org/I4210086696', 'display_name': 'Biomedical Research Networking Center on Neurodegenerative Diseases', 'ror': 'https://ror.org/00zca7903', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I4210086696']}, {'id': 'https://openalex.org/I4210086614', 'display_name': 'Research Institute Hospital 12 de Octubre', 'ror': 'https://ror.org/002x1sg85', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210086614']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Rocío Pérez-Gonzalez', 'raw_affiliation_strings': ['Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Avenida de Córdoba s/n. 28041, Madrid, Spain', 'Laboratory of Neuroscience, Research Center, Hospital 12 de Octubre, Avenida de Córdoba s/n. 28041, Madrid, Spain'], 'affiliations': [{'raw_affiliation_string': 'Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Avenida de Córdoba s/n. 28041, Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210086696']}, {'raw_affiliation_string': 'Laboratory of Neuroscience, Research Center, Hospital 12 de Octubre, Avenida de Córdoba s/n. 28041, Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210086614']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089455888', 'display_name': 'Carlos Spuch', 'orcid': 'https://orcid.org/0000-0002-9161-0124'}, 'institutions': [{'id': 'https://openalex.org/I4210086696', 'display_name': 'Biomedical Research Networking Center on Neurodegenerative Diseases', 'ror': 'https://ror.org/00zca7903', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I4210086696']}, {'id': 'https://openalex.org/I4210086614', 'display_name': 'Research Institute Hospital 12 de Octubre', 'ror': 'https://ror.org/002x1sg85', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210086614']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Carlos Spuch', 'raw_affiliation_strings': ['Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Avenida de Córdoba s/n. 28041, Madrid, Spain', 'Laboratory of Neuroscience, Research Center, Hospital 12 de Octubre, Avenida de Córdoba s/n. 28041, Madrid, Spain'], 'affiliations': [{'raw_affiliation_string': 'Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Avenida de Córdoba s/n. 28041, Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210086696']}, {'raw_affiliation_string': 'Laboratory of Neuroscience, Research Center, Hospital 12 de Octubre, Avenida de Córdoba s/n. 28041, Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210086614']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005095530', 'display_name': 'Teodoro Vargas', 'orcid': 'https://orcid.org/0000-0002-8262-6810'}, 'institutions': [{'id': 'https://openalex.org/I4210086696', 'display_name': 'Biomedical Research Networking Center on Neurodegenerative Diseases', 'ror': 'https://ror.org/00zca7903', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I4210086696']}, {'id': 'https://openalex.org/I4210086614', 'display_name': 'Research Institute Hospital 12 de Octubre', 'ror': 'https://ror.org/002x1sg85', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210086614']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Teo Vargas', 'raw_affiliation_strings': ['Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Avenida de Córdoba s/n. 28041, Madrid, Spain', 'Laboratory of Neuroscience, Research Center, Hospital 12 de Octubre, Avenida de Córdoba s/n. 28041, Madrid, Spain'], 'affiliations': [{'raw_affiliation_string': 'Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Avenida de Córdoba s/n. 28041, Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210086696']}, {'raw_affiliation_string': 'Laboratory of Neuroscience, Research Center, Hospital 12 de Octubre, Avenida de Córdoba s/n. 28041, Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210086614']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080174576', 'display_name': 'Desireé Antequera', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210086696', 'display_name': 'Biomedical Research Networking Center on Neurodegenerative Diseases', 'ror': 'https://ror.org/00zca7903', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I4210086696']}, {'id': 'https://openalex.org/I4210086614', 'display_name': 'Research Institute Hospital 12 de Octubre', 'ror': 'https://ror.org/002x1sg85', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210086614']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Desiree Antequera', 'raw_affiliation_strings': ['Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Avenida de Córdoba s/n. 28041, Madrid, Spain', 'Laboratory of Neuroscience, Research Center, Hospital 12 de Octubre, Avenida de Córdoba s/n. 28041, Madrid, Spain'], 'affiliations': [{'raw_affiliation_string': 'Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Avenida de Córdoba s/n. 28041, Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210086696']}, {'raw_affiliation_string': 'Laboratory of Neuroscience, Research Center, Hospital 12 de Octubre, Avenida de Córdoba s/n. 28041, Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210086614']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063673202', 'display_name': 'Miguel Garzón', 'orcid': 'https://orcid.org/0000-0003-0438-5158'}, 'institutions': [{'id': 'https://openalex.org/I63634437', 'display_name': 'Autonomous University of Madrid', 'ror': 'https://ror.org/01cby8j38', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I63634437']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Miguel Garzón', 'raw_affiliation_strings': ['Department of Anatomy, Histology and Neuroscience, Universidad Autónoma de Madrid, C/Arzobispo Morcillo 4. 28029, Madrid, Spain'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomy, Histology and Neuroscience, Universidad Autónoma de Madrid, C/Arzobispo Morcillo 4. 28029, Madrid, Spain', 'institution_ids': ['https://openalex.org/I63634437']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019197183', 'display_name': 'Félix Bermejo‐Pareja', 'orcid': 'https://orcid.org/0000-0002-5413-232X'}, 'institutions': [{'id': 'https://openalex.org/I4210086696', 'display_name': 'Biomedical Research Networking Center on Neurodegenerative Diseases', 'ror': 'https://ror.org/00zca7903', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I4210086696']}, {'id': 'https://openalex.org/I4210086614', 'display_name': 'Research Institute Hospital 12 de Octubre', 'ror': 'https://ror.org/002x1sg85', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210086614']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Felix Bermejo-Pareja', 'raw_affiliation_strings': ['Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Avenida de Córdoba s/n. 28041, Madrid, Spain', 'Neurology Department, Hospital 12 de Octubre, Avenida de Córdoba s/n. 28041, Madrid, Spain'], 'affiliations': [{'raw_affiliation_string': 'Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Avenida de Córdoba s/n. 28041, Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210086696']}, {'raw_affiliation_string': 'Neurology Department, Hospital 12 de Octubre, Avenida de Córdoba s/n. 28041, Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210086614']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5029022905', 'display_name': 'Eva Carro', 'orcid': 'https://orcid.org/0000-0002-6504-4579'}, 'institutions': [{'id': 'https://openalex.org/I4210086696', 'display_name': 'Biomedical Research Networking Center on Neurodegenerative Diseases', 'ror': 'https://ror.org/00zca7903', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I4210086696']}, {'id': 'https://openalex.org/I4210086614', 'display_name': 'Research Institute Hospital 12 de Octubre', 'ror': 'https://ror.org/002x1sg85', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210086614']}], 'countries': ['ES'], 'is_corresponding': True, 'raw_author_name': 'Eva Carro', 'raw_affiliation_strings': ['Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Avenida de Córdoba s/n. 28041, Madrid, Spain', 'Laboratory of Neuroscience, Research Center, Hospital 12 de Octubre, Avenida de Córdoba s/n. 28041, Madrid, Spain'], 'affiliations': [{'raw_affiliation_string': 'Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Avenida de Córdoba s/n. 28041, Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210086696']}, {'raw_affiliation_string': 'Laboratory of Neuroscience, Research Center, Hospital 12 de Octubre, Avenida de Córdoba s/n. 28041, Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210086614']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5029022905'], 'corresponding_institution_ids': ['https://openalex.org/I4210086696', 'https://openalex.org/I4210086614'], 'apc_list': {'value': 3570, 'currency': 'USD', 'value_usd': 3570, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.813, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 60, 'citation_normalized_percentile': {'value': 0.935034, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '45', 'issue': '3', 'first_page': '306', 'last_page': '315'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10086', 'display_name': "Mechanisms of Alzheimer's Disease", 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10086', 'display_name': "Mechanisms of Alzheimer's Disease", 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12023', 'display_name': 'Cholinesterase Inhibitors in Neurodegenerative Diseases', 'score': 0.9694, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10077', 'display_name': 'Molecular Mechanisms of Synaptic Plasticity and Neurological Disorders', 'score': 0.9625, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/internalization', 'display_name': 'Internalization', 'score': 0.71786547}, {'id': 'https://openalex.org/keywords/neurite', 'display_name': 'Neurite', 'score': 0.6097025}, {'id': 'https://openalex.org/keywords/protein-misfolding', 'display_name': 'Protein Misfolding', 'score': 0.483474}, {'id': 'https://openalex.org/keywords/neurotoxicity', 'display_name': 'Neurotoxicity', 'score': 0.48033822}], 'concepts': [{'id': 'https://openalex.org/C2776538271', 'wikidata': 'https://www.wikidata.org/wiki/Q926250', 'display_name': 'Choroid plexus', 'level': 3, 'score': 0.7328421}, {'id': 'https://openalex.org/C139770010', 'wikidata': 'https://www.wikidata.org/wiki/Q1339807', 'display_name': 'Internalization', 'level': 3, 'score': 0.71786547}, {'id': 'https://openalex.org/C183786373', 'wikidata': 'https://www.wikidata.org/wiki/Q5964993', 'display_name': 'Signal transducing adaptor protein', 'level': 3, 'score': 0.6446639}, {'id': 'https://openalex.org/C113246987', 'wikidata': 'https://www.wikidata.org/wiki/Q1534415', 'display_name': 'Neurite', 'level': 3, 'score': 0.6097025}, {'id': 'https://openalex.org/C31705614', 'wikidata': 'https://www.wikidata.org/wiki/Q423510', 'display_name': 'Amyloid precursor protein', 'level': 4, 'score': 0.5829627}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.569714}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.56208587}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5360848}, {'id': 'https://openalex.org/C2779491297', 'wikidata': 'https://www.wikidata.org/wiki/Q3338704', 'display_name': 'Neurotoxicity', 'level': 3, 'score': 0.48033822}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.41997826}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.40478063}, {'id': 'https://openalex.org/C502032728', 'wikidata': 'https://www.wikidata.org/wiki/Q11081', 'display_name': "Alzheimer's disease", 'level': 3, 'score': 0.30357876}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.24133798}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.20810348}, {'id': 'https://openalex.org/C529278444', 'wikidata': 'https://www.wikidata.org/wiki/Q47273', 'display_name': 'Central nervous system', 'level': 2, 'score': 0.18626931}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.14994064}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.11910987}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0833959}, {'id': 'https://openalex.org/C29730261', 'wikidata': 'https://www.wikidata.org/wiki/Q274160', 'display_name': 'Toxicity', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D016564', 'descriptor_name': 'Amyloid beta-Protein Precursor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D026561', 'descriptor_name': 'Low Density Lipoprotein Receptor-Related Protein-2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016564', 'descriptor_name': 'Amyloid beta-Protein Precursor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016564', 'descriptor_name': 'Amyloid beta-Protein Precursor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000033', 'qualifier_name': 'anatomy & histology', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D026561', 'descriptor_name': 'Low Density Lipoprotein Receptor-Related Protein-2', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D026561', 'descriptor_name': 'Low Density Lipoprotein Receptor-Related Protein-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.mcn.2010.07.005', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47891569', 'display_name': 'Molecular and Cellular Neuroscience', 'issn_l': '1044-7431', 'issn': ['1044-7431', '1095-9327'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20637285', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 53, 'referenced_works': ['https://openalex.org/W1667130205', 'https://openalex.org/W1684032030', 'https://openalex.org/W1879138788', 'https://openalex.org/W1964133995', 'https://openalex.org/W1970195398', 'https://openalex.org/W1975830708', 'https://openalex.org/W1979132231', 'https://openalex.org/W1979890201', 'https://openalex.org/W1983050931', 'https://openalex.org/W1984849799', 'https://openalex.org/W1985802666', 'https://openalex.org/W1987095222', 'https://openalex.org/W1988986946', 'https://openalex.org/W1991238165', 'https://openalex.org/W1992260035', 'https://openalex.org/W1993772406', 'https://openalex.org/W1997964766', 'https://openalex.org/W2002507728', 'https://openalex.org/W2005010112', 'https://openalex.org/W2009347734', 'https://openalex.org/W2010267756', 'https://openalex.org/W2015521587', 'https://openalex.org/W2027353535', 'https://openalex.org/W2030402418', 'https://openalex.org/W2030752095', 'https://openalex.org/W2032838825', 'https://openalex.org/W2033379465', 'https://openalex.org/W2035833915', 'https://openalex.org/W2043915463', 'https://openalex.org/W2048258807', 'https://openalex.org/W2052648526', 'https://openalex.org/W2053877185', 'https://openalex.org/W2058253080', 'https://openalex.org/W2061049088', 'https://openalex.org/W2064604181', 'https://openalex.org/W2072303926', 'https://openalex.org/W2073140013', 'https://openalex.org/W2090097368', 'https://openalex.org/W2090710011', 'https://openalex.org/W2092946338', 'https://openalex.org/W2114647375', 'https://openalex.org/W2115922577', 'https://openalex.org/W2130112708', 'https://openalex.org/W2131065520', 'https://openalex.org/W2131819352', 'https://openalex.org/W2137667246', 'https://openalex.org/W2139749945', 'https://openalex.org/W2148351021', 'https://openalex.org/W2167775888', 'https://openalex.org/W2170250556', 'https://openalex.org/W2405436390', 'https://openalex.org/W4297715970', 'https://openalex.org/W617643949'], 'related_works': ['https://openalex.org/W4366318089', 'https://openalex.org/W4225584766', 'https://openalex.org/W2170250556', 'https://openalex.org/W2137575965', 'https://openalex.org/W2068721292', 'https://openalex.org/W2047690647', 'https://openalex.org/W1993157596', 'https://openalex.org/W1971395280', 'https://openalex.org/W1970300511', 'https://openalex.org/W1465810312'], 'abstract_inverted_index': {'Increasing': [0], 'evidence': [1], 'has': [2, 45, 147], 'implicated': [3], 'megalin,': [4], 'a': [5, 126], 'low-density': [6], 'lipoprotein': [7, 79], 'receptor-related': [8, 80], 'protein,': [9], 'in': [10, 23, 34, 49, 63, 108, 137, 151, 159, 165], 'the': [11, 18, 35, 66, 73, 76, 83, 90, 96, 160], 'pathogenesis': [12], 'of': [13, 37, 92], "Alzheimer's": [14], 'disease': [15], '(AD).': [16], 'In': [17, 53], 'brain,': [19], 'megalin': [20, 44, 59, 102, 114, 134, 146], 'is': [21, 60], 'expressed': [22], 'brain': [24, 38], 'capillaries,': [25], 'ependymal': [26], 'cells': [27], 'and': [28, 51, 82, 118, 154], 'choroid': [29], 'plexus,': [30], 'where': [31], 'it': [32], 'participates': [33], 'clearance': [36], 'amyloid': [39, 84], 'β-peptide': [40], '(Aβ)': [41], 'complex.': [42, 128], 'Recently,': [43], 'also': [46, 104], 'been': [47], 'detected': [48], 'oligodendrocytes': [50], 'astrocytes.': [52], 'this': [54], 'study': [55], 'we': [56, 99], 'demonstrate': [57], 'that': [58, 70, 101, 113, 121, 133, 145, 163], 'widely': [61], 'distributed': [62], 'neurons': [64], 'throughout': [65], 'brain.': [67], 'Additionally,': [68], 'given': [69], 'FE65': [71], 'mediates': [72], 'interaction': [74], 'between': [75], 'low': [77], 'density': [78], 'protein-1': [81], 'precursor': [85], 'protein': [86], '(APP)': [87], 'to': [88], 'modulate': [89], 'rate': [91], 'APP': [93, 107, 117], 'internalization': [94], 'from': [95], 'cell': [97], 'surface,': [98], 'hypothesize': [100], 'could': [103], 'interact': [105], 'with': [106, 116], 'neurons.': [109], 'Our': [110], 'results': [111, 143], 'confirm': [112], 'interacts': [115], 'FE65,': [119], 'suggesting': [120], 'these': [122, 142], 'three': [123], 'proteins': [124], 'form': [125], 'tripartite': [127], 'Moreover,': [129], 'our': [130], 'findings': [131], 'imply': [132], 'may': [135, 156], 'participate': [136], 'neurite': [138], 'branching.': [139], 'Taken': [140], 'together,': [141], 'indicate': [144], 'an': [148], 'important': [149], 'role': [150], 'Aβ-mediated': [152], 'neurotoxicity,': [153], 'therefore': [155], 'be': [157], 'involved': [158], 'neurodegenerative': [161], 'processes': [162], 'occur': [164], 'AD.': [166]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2062904433', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-08-31T20:44:17.065886', 'created_date': '2016-06-24'}