Publication Information

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2945, 2969, 4156, 4177, 4297, 4332], 'by': [22, 56, 236, 270, 464, 607, 791, 945, 1432, 1472, 1544, 1901, 1916, 1944, 1985, 2002, 2067, 2096, 2112, 2164, 2177, 2181, 2259, 2281, 2375, 3350, 3825, 3841, 4406, 4540, 4781, 4791, 5143, 5178, 5196, 5318], 'inflammatory': [23, 237, 481, 507, 559, 619, 1421, 2666, 2730, 4720, 4831], 'lipases,': [24, 238], 'we': [25, 47, 125, 239, 261, 339, 1122, 1204, 1224, 3002, 3064, 3126, 3167, 3185, 3357, 3416, 3992, 4152, 4381, 4585, 5387], 'hypothesized': [26, 240], 'they': [28, 242, 1091, 1347, 2436, 3231], 'may': [29, 243, 562, 903, 1064, 3291, 3925, 4598, 4622, 5139, 5169, 5357], 'be': [30, 244, 564, 1504, 2575, 2802, 2852, 3174, 3660, 3783, 3926, 3968, 4378, 4623, 5359, 5400], 'involved': [31, 245, 717, 3818, 3843, 4624], 'the': [33, 49, 67, 71, 77, 127, 141, 172, 194, 197, 203, 247, 263, 281, 285, 291, 341, 355, 386, 409, 412, 418, 437, 453, 496, 519, 522, 532, 570, 575, 608, 611, 738, 775, 815, 830, 963, 1075, 1201, 1221, 1227, 1238, 1243, 1282, 1285, 1295, 1310, 1318, 1323, 1344, 1349, 1355, 1384, 1414, 1426, 1465, 1517, 1577, 1582, 1686, 1689, 1696, 1713, 1745, 1762, 1767, 1789, 1868, 1914, 1952, 2113, 2129, 2144, 2172, 2182, 2206, 2255, 2261, 2267, 2331, 2371, 2387, 2431, 2433, 2438, 2445, 2448, 2483, 2489, 2520, 2613, 2814, 2831, 2866, 2875, 2887, 2896, 2902, 2918, 2948, 2983, 2986, 2999, 3005, 3019, 3030, 3034, 3038, 3041, 3045, 3054, 3066, 3079, 3087, 3115, 3122, 3132, 3145, 3160, 3188, 3203, 3215, 3226, 3234, 3259, 3263, 3267, 3285, 3300, 3311, 3324, 3335, 3338, 3354, 3361, 3365, 3382, 3391, 3395, 3406, 3418, 3437, 3470, 3487, 3502, 3522, 3534, 3538, 3548, 3571, 3624, 3711, 3714, 3747, 3801, 3804, 3817, 3827, 3836, 3842, 3929, 3940, 3943, 3952, 3964, 3980, 3994, 4149, 4183, 4212, 4295, 4313, 4372, 4384, 4393, 4398, 4407, 4414, 4422, 4430, 4444, 4453, 4475, 4480, 4493, 4497, 4505, 4521, 4526, 4534, 4541, 4546, 4550, 4559, 4565, 4571, 4594, 4606, 4626, 4634, 4663, 4701, 4774, 4786, 4851, 4879, 4913, 4917, 4925, 4934, 4940, 4993, 5004, 5033, 5050, 5078, 5119, 5151, 5165, 5179, 5215, 5238, 5246, 5298, 5365, 5403, 5407, 5438, 5445, 5468, 5472, 5492], 'process': [34, 248], 'of': [35, 52, 105, 205, 249, 266, 319, 420, 441, 452, 468, 480, 490, 495, 521, 534, 549, 583, 610, 625, 641, 737, 746, 749, 760, 777, 798, 819, 825, 850, 889, 1120, 1126, 1210, 1245, 1284, 1322, 1326, 1351, 1386, 1398, 1401, 1416, 1429, 1449, 1467, 1474, 1509, 1519, 1538, 1556, 1615, 1658, 1683, 1688, 1715, 1747, 1764, 1836, 1867, 1899, 1907, 1927, 1977, 2017, 2050, 2069, 2094, 2117, 2131, 2138, 2171, 2185, 2196, 2266, 2290, 2358, 2370, 2389, 2392, 2440, 2509, 2543, 2612, 2678, 2742, 2806, 2824, 2833, 2862, 2868, 2877, 2921, 2944, 2950, 2967, 2985, 3007, 3029, 3033, 3044, 3089, 3118, 3131, 3147, 3163, 3182, 3206, 3228, 3364, 3381, 3409, 3423, 3429, 3469, 3510, 3552, 3570, 3631, 3643, 3673, 3716, 3754, 3766, 3806, 3816, 3878, 3933, 3942, 3951, 3984, 4007, 4041, 4098, 4136, 4158, 4174, 4211, 4330, 4361, 4387, 4400, 4452, 4486, 4496, 4508, 4529, 4570, 4578, 4590, 4629, 4643, 4666, 4693, 4700, 4716, 4746, 4776, 4783, 4789, 4853, 4878, 4903, 4919, 4924, 4942, 4979, 5008, 5016, 5038, 5096, 5154, 5181, 5192, 5214, 5228, 5240, 5279, 5312, 5340, 5382, 5405, 5410, 5418, 5425, 5432, 5440, 5471, 5479], 'acute': [36, 250, 4778], 'systemic': [37, 210, 251, 425, 432, 466, 478, 1420, 2665, 2729, 4779, 4820, 5011], 'sepsis.': [38, 252, 1352, 1390, 1748, 2441, 2996, 3183], 'In': [39, 123, 253, 337, 900, 1200, 1218, 2402, 2442, 2568, 2885, 3331, 3402, 3975, 4148, 4193, 4524, 4641, 5443], 'order': [40, 254, 3332, 3403, 3976], 'to': [41, 255, 434, 476, 485, 556, 832, 860, 923, 975, 1033, 1072, 1185, 1220, 1250, 1258, 1317, 1354, 1443, 1491, 1503, 1526, 1652, 1712, 1743, 1788, 1913, 1951, 2024, 2275, 2330, 2348, 2444, 2574, 2851, 2998, 3009, 3052, 3098, 3114, 3159, 3176, 3293, 3333, 3345, 3390, 3404, 3467, 3501, 3659, 3782, 3957, 3970, 3977, 4083, 4121, 4220, 4279, 4318, 4433, 4491, 4587, 4633, 4668, 4672, 4921, 5003, 5031, 5146, 5174, 5211, 5224, 5285, 5295, 5372, 5385, 5429, 5460], 'provide': [42, 196, 256, 411, 1092, 1205, 4599, 5447], 'support': [43, 257, 1274, 4642, 5449], 'for': [44, 76, 145, 181, 202, 258, 290, 359, 395, 417, 574, 598, 742, 962, 1096, 1242, 1277, 1289, 1376, 1383, 1455, 1485, 1664, 1692, 1706, 1766, 2215, 2221, 2234, 2239, 2293, 2414, 2421, 2485, 2499, 2670, 2734, 2906, 2964, 3057, 3258, 3369, 3385, 3394, 3533, 3653, 3662, 3677, 3776, 3785, 4299, 4397, 4479, 4516, 4592, 4750, 4891, 4972, 5049, 5077, 5315, 5450, 5463], 'this': [45, 259, 1290, 1638, 2583, 3386, 3936, 4644, 4973, 5375], 'hypothesis,': [46, 260, 4645], 'analyzed': [48, 262, 1226, 2001, 3360, 3417, 3554, 3981, 4572], 'levels': [51, 265, 1103, 1125, 1209, 2848, 4033, 4157, 4197, 4203, 4551, 4788, 5157, 5417], 'Cer': [53, 109, 206, 267, 323, 421, 837, 902, 911, 958, 1063, 1079, 1128, 1211, 1278, 1940, 1999, 2046, 2072, 2793, 2835, 2891, 2907, 2924, 4159, 4196, 4302, 4409, 4417, 4432, 4655, 4845, 4904, 4920, 4938, 5464], 'LPC': [55, 118, 269, 332, 605, 770, 1081, 1213, 1280, 1883, 2074, 2108, 2946, 2970, 2978, 2988, 3008, 3085, 3094, 3103, 3120, 3124, 4161, 4178, 4185, 4300, 4620, 5023, 5041, 5138, 5156, 5167], 'quantitative': [57, 271], 'tandem': [58, 272, 1902, 1947, 1988, 2099, 3021, 5392], 'mass': [59, 273, 1903, 1948, 1989, 2028, 2100, 2201, 2941, 3022, 5393], 'spectrometry': [60, 274, 1949, 1990, 3023], '102': [62, 276, 1215], 'sepsis': [63, 72, 114, 163, 277, 286, 328, 377, 454, 523, 851, 933, 1131, 1216, 1286, 1377, 1409, 1693, 1765, 2486, 2558, 2825, 2843, 2872, 2913, 3137, 3148, 4166, 4191, 4205, 4304, 4412, 4441, 4509, 4583, 5162, 5366, 5473], 'patients': [64, 278, 852, 1132, 1307, 1313, 1340, 1709, 1760, 1822, 2427, 2478, 2505, 2517, 2525, 2532, 2559, 2826, 2873, 2914, 2937, 2994, 3138, 3149, 3371, 3846, 3879, 4001, 4046, 4167, 4305, 4579, 4591, 4985], 'starting': [65, 279], 'with': [66, 93, 99, 130, 184, 280, 307, 313, 344, 399, 518, 829, 916, 971, 1055, 1107, 1116, 1230, 1262, 1425, 1549, 1566, 1622, 1893, 1956, 2006, 2035, 2205, 2251, 2368, 2564, 2580, 2607, 2795, 2809, 2818, 2855, 2895, 2935, 2995, 3140, 3157, 3247, 3262, 3275, 3323, 3462, 3464, 3481, 3599, 3847, 3880, 3988, 4002, 4035, 4047, 4089, 4127, 4169, 4207, 4421, 4520, 4574, 4609, 4719, 4850, 4929, 4989, 5010, 5027, 5093, 5415], 'day': [68, 84, 87, 282, 298, 301, 1824, 1826, 1829, 2535, 2538, 3213, 3220, 3223, 3250, 3308, 3314, 3317, 3343, 3346, 3454, 3457, 3484, 3490, 3493, 3529, 3543, 3546, 4022, 4105, 4143], 'at': [69, 283, 1417, 1478, 1499, 1798, 1823, 2263, 2591, 2608, 3037, 3219, 3453, 3483, 3489, 3528, 3564, 3579, 3686, 3830, 4021, 4104, 4142, 4502, 4887], 'which': [70, 139, 284, 353, 920, 1529, 1539, 2395, 3562, 4391, 4661, 5054, 5148, 5386], 'criteria': [73, 287, 1350, 1424, 1654, 1691, 1763, 2439, 2484], 'were': [74, 91, 111, 120, 155, 160, 288, 305, 325, 334, 369, 374, 1248, 1315, 1334, 1341, 1440, 1461, 1541, 1608, 1633, 1643, 1671, 1704, 1710, 1774, 1785, 1811, 1843, 1851, 1856, 1866, 1885, 1942, 2110, 2151, 2162, 2273, 2300, 2312, 2327, 2428, 2479, 2497, 2560, 2849, 2909, 3096, 3319, 3388, 3477, 3657, 3780, 3886, 4102, 4140, 4316, 4436], 'fulfilled': [75, 289, 1348, 1761, 2437, 2482], 'first': [78, 198, 292, 413, 1750, 1768, 2434, 2521], 'time,': [79, 293], 'as': [80, 82, 149, 151, 169, 171, 294, 296, 363, 365, 383, 385, 470, 472, 566, 581, 595, 856, 906, 1470, 1533, 1581, 1645, 1728, 1755, 1757, 1845, 2059, 2077, 2125, 2153, 2338, 2684, 2748, 2813, 2980, 2982, 3076, 3078, 3108, 3110, 3566, 3568, 3710, 3800, 3839, 4028, 4030, 4306, 4308, 4427, 4429, 4448, 4450, 4616, 4618, 4711, 4713, 5021, 5046, 5074, 5369], 'well': [81, 150, 170, 295, 364, 384, 471, 2981, 3077, 3109, 4029, 4307, 4428, 4449, 4617, 4712, 5020], 'on': [83, 297, 615, 1207, 1413, 1551, 1574, 1720, 2318, 3014, 3187, 3191, 3212, 3307, 3313, 3820, 3920, 5135, 5234, 5281], '4': [85, 299, 3221, 3251, 3315, 3455, 3491, 3544, 4018], '11.': [88, 302], 'The': [89, 165, 303, 379, 448, 1391, 1640, 1708, 1733, 1749, 1832, 2045, 2169, 2198, 2285, 2334, 2342, 2356, 2411, 2540, 3378, 3434, 3575, 3870, 4013, 4172, 4483, 4687, 4843, 4976, 5013, 5475], 'values': [90, 304, 2681, 2745, 3440, 3527, 3551, 3578, 3652, 3775, 3954, 4101, 4139], 'compared': [92, 306, 2367, 2563, 2579, 2854, 2934, 3139, 3246, 3274, 3322, 3993, 4168, 4519], '56': [94, 308, 1837], 'healthy': [95, 309, 1838, 2566, 2807, 3151, 4170, 4309, 4554], 'controls': [96, 310, 2856, 3141, 3152, 4310], 'correlated': [98, 312], 'sepsis-related': [100, 182, 314, 396, 1259, 2364, 2510, 3424, 3591, 3678, 3958, 4517, 4610, 5028], 'mortality': [101, 315, 1721, 2365, 3425, 3482, 3592, 3634, 3679, 3757, 4518, 4611, 4991, 5029], 'within': [102, 316, 1722, 1800, 2519, 2527, 3426, 3593, 3635, 3680, 3758, 4336], '30': [103, 317, 1723, 2502, 3427, 3594, 3636, 3681, 3759], 'days': [104, 318, 1724, 1777, 1780, 3428, 3595, 3637, 3682, 3760], 'study': [106, 320, 1115, 1291, 1345, 1726, 2432, 2592, 3355, 3397, 3430, 3597, 3639, 3684, 3762, 3831, 3966, 4108, 4146, 4226, 4535], 'entry.': [107, 321, 3640, 3763, 4109, 4147], 'Most': [108, 322], 'species': [110, 119, 324, 333, 1129, 1941, 1980, 2109, 2147, 2161, 2189, 2794, 2836, 2894, 3061, 3095, 4420, 4455], 'increased': [112, 166, 326, 380, 622, 1124, 2841, 2911, 3218, 4202, 4532, 4614, 4980, 5247], 'patients,': [115, 329, 2844, 4206, 4413], 'while': [116, 330, 3230], 'all': [117, 331, 1306, 1852, 1886, 2396, 2403, 2878, 3090, 3375, 3553, 3654, 3777, 4175, 4530], 'markedly': [121, 335, 2561, 2930, 2991, 4188], 'decreased.': [122, 336], 'addition,': [124, 338, 901, 2569], 'determined': [126, 340, 1471, 1844, 2313, 3065, 4103, 4141, 4383], 'molar': [128, 342, 1228, 2888, 2919, 3016, 3055, 3067, 3134, 3161, 3204, 3367, 3383, 3410, 3587, 3674, 4042, 4385, 4468], 'ratios': [129, 154, 159, 168, 175, 343, 368, 373, 382, 389, 1229, 1236, 2889, 3056, 3068, 3080, 3135, 3162, 3172, 3189, 3205, 3216, 3243, 3328, 3368, 3384, 3452, 3476, 3556, 3589, 3649, 3676, 3772, 3829, 3877, 3983, 3999, 4044, 4386, 4415, 4470, 4531, 4547, 4982, 5018, 5414], 'their': [131, 146, 345, 360, 1101, 1231, 4908, 5262], 'precursor': [132, 346, 1233, 3011], 'molecules': [133, 347, 627, 648], 'sphingomyelin': [134, 348, 820, 5500], '(SPM)': [135, 349], 'phosphatidylcholine': [137, 351, 616, 5496], '(PC),': [138, 352], 'reflect': [140, 354, 4392, 5170], 'enzymatic': [142, 356, 1239, 2316, 2903, 4394], 'reactions': [143, 357, 1240, 4395], 'responsible': [144, 358, 1241, 2905, 4396], 'formation.': [147, 361], 'Species-specific': [148, 362], 'total': [152, 366, 1928, 2268, 2869, 2922, 2926, 2968, 2977, 3074, 3099, 3119, 3192, 4184, 4195, 4431, 4445], 'Cer-SPM': [153, 167, 367, 381, 3000, 3164, 3207, 3242, 3288, 3325, 3448, 3871, 4388, 4469, 4981], 'increased,': [156, 370], 'whereas': [157, 371, 4556, 5293], 'LPC-PC': [158, 174, 372, 388, 3060, 3260, 3268, 3290, 3327, 3451, 3648, 3771, 3873, 4481, 5017], 'decreased': [161, 173, 375, 387, 2853, 4189, 4619, 5166], 'patients.': [164, 378, 1217, 2476, 2679, 2743, 4192, 4442, 4465, 4640, 5163], 'showed': [176, 390, 2827, 3495, 4198, 4768], 'a': [177, 391, 431, 458, 465, 477, 579, 596, 639, 795, 826, 839, 857, 886, 931, 960, 977, 1093, 1113, 1117, 1252, 1275, 1557, 1587, 1595, 2007, 2014, 2025, 2060, 2080, 2135, 2319, 2377, 2390, 2565, 2725, 2796, 2860, 3015, 3128, 3496, 3667, 3721, 3726, 3811, 3948, 4113, 4199, 4224, 4327, 4472, 4649, 4741, 4771, 4792, 4827, 4876, 5047, 5075, 5126, 5182, 5226, 5370, 5379, 5461], 'strong': [178, 392, 925, 4607], 'predictive': [179, 393, 1254, 3407, 3511, 3526, 3550, 3577, 3661, 3784, 3953, 4494, 4514, 4568], 'power': [180, 394, 1255, 3341, 3498, 3672, 4515, 4569], 'mortality.Together': [183], 'existing': [185, 400, 1263], 'from': [187, 402, 1214, 1265, 1294, 1305, 1511, 1560, 1584, 1590, 1600, 1620, 1813, 1857, 1875, 1887, 1981, 3106, 3249, 3342, 3963, 4223, 4995, 5456], 'vitro': [189, 404, 744, 1267, 4998, 5452], 'experiments': [190, 405, 1268, 4999, 5453], 'animal': [192, 407, 1270, 5001, 5457], 'models,': [193, 408, 1271], 'results': [195, 410, 2272, 3944, 4222], 'ex': [199, 414], 'vivo': [200, 415, 5006], 'indication': [201, 416], 'role': [204, 419, 580, 1276, 5462], 'lysophospholipids': [208, 423, 5466], 'inflammation': [211, 426, 4652, 4780, 4821, 5267], 'humans.': [213, 428], 'mortality.': [397, 1260, 3663, 3786, 3959], 'Together': [398, 1261], 'Sepsis': [429], 'is': [430, 462, 586, 716, 794, 822, 838, 921, 959, 1052, 1088, 3513, 3563, 4334, 4538, 5055, 5222, 5487], 'response': [433, 461, 1422, 2667, 2731], 'infection': [435, 1431, 1524, 1548], 'most': [438, 2834], 'common': [439], 'cause': [440, 930], 'death': [442], 'noncoronary': [444], 'intensive': [445, 1319], 'care': [446, 1320], 'units.': [447], 'current': [449, 1202, 4977], 'pathophysiological': [450, 5190], 'concepts': [451], 'syndrome': [455, 524, 934, 1423, 5092], 'suggest': [456, 4648, 4968], 'local': [459, 1296], 'followed': [463], 'release': [467], 'proinflammatory': [469, 612, 926, 5036], 'antiinflammatory': [473], 'mediators,': [474], 'leading': [475, 4632], 'disturbance': [479], 'balance': [482], 'leads': [484], 'progressive': [486], 'endothelial': [487, 623, 655, 678, 4717, 4738, 5248], 'dysfunction,': [488], 'loss': [489], 'pressure': [492, 2229], 'control,': [493], 'deterioration': [494], 'coagulation': [497], 'system,': [498], 'ultimately': [500], 'multiple': [501, 890], 'organ': [502, 891, 1379], 'dysfunctions.': [503], 'Beside': [504], 'cytokines,': [505], 'well-established': [506], 'lipid': [508, 828, 1929, 3588, 3675, 3821, 3828, 4038, 4043, 4596, 5377, 5413], 'mediators': [509, 530, 568], 'like': [510, 5237], 'platelet-activating': [511], 'factor': [512, 672, 740], 'eicosanoids': [514], 'have': [515, 954, 1251, 3358, 4153], 'been': [516, 772, 854, 4848, 5044], 'associated': [517, 3461, 3480, 4849], 'development': [520, 4852], '(1Bulger': [525], 'E.M.': [526], 'Maier': [527], 'R.V.': [528], 'Lipid': [529, 1992, 2680, 2744], 'pathophysiology': [533, 1283, 5470], 'critical': [535], 'illness.Crit.': [536], 'Care': [537, 894, 1403], 'Med.': [538, 895], '2000;': [539, 723, 802, 809, 4839, 5323, 5351], '28:': [540], 'N27-N36Google': [541], 'Scholar).': [542, 604, 768, 812, 899, 952, 1047, 1199, 1459, 1668, 1939, 1997, 2106, 4293, 4370, 4762, 4842, 5085, 5133, 5208, 5354], 'other': [547, 972, 3655, 3778, 4930], 'groups': [548, 4088, 4126], 'similarly': [552], 'transfer': [553], 'significant': [554, 2828, 3129, 4328], 'effects': [555, 4321, 5037, 5233], 'cells': [560, 793, 849, 944, 1570, 4718, 4739], 'therefore': [563], 'regarded': [565], 'candidate': [567, 5362], 'septic': [571, 884, 2933, 4639, 4984], 'process.': [572], 'Thus,': [573, 910, 3960, 4326, 5355], 'lysophospholipid': [576, 758], '(LPC),': [578], 'regulator': [582], 'functions': [585, 4971, 5142], 'emerging': [587], '(2Kabarowski': [588], 'J.H.': [589, 4869, 5064, 5104], 'Xu': [590, 5071], 'Y.': [591, 5072, 5304, 5328, 5332], 'Witte': [592, 5069, 5115], 'O.N.': [593, 5070, 5116], 'Lysophosphatidylcholine': [594, 668, 700, 5073], 'ligand': [597, 961, 5048, 5076], 'immunoregulation.Biochem.': [599], 'Pharmacol.': [600], '2002;': [601, 2103, 4963, 5205, 5272], '64:': [602], '161-167Google': [603], 'produced': [606, 5195], 'action': [609], 'phospholipase': [613], 'A2': [614], '(PC)': [617], 'promotes': [618, 4907], 'effects,': [620], 'including': [621, 2254, 2837, 5231], 'expression': [624, 674, 5251, 5311, 5336], 'adhesion': [626, 647, 5249], 'growth': [629, 671, 1473, 1555], 'factors': [630], '(3Kume': [631], 'N.': [632, 664, 731, 4729, 4802], 'Cybulsky': [633], 'M.I.': [634], 'Gimbrone': [635, 665], 'Jr.,': [636, 666], 'M.A.': [637, 667], 'Lysophosphatidylcholine,': [638], 'component': [640], 'atherogenic': [642, 4885], 'lipoproteins,': [643], 'induces': [644, 670, 968], 'mononuclear': [645, 848], 'leukocyte': [646], 'cultured': [650, 676], 'human': [651, 677, 5319, 5346], 'rabbit': [653], 'arterial': [654], 'cells.J.': [656, 679], 'Clin.': [657, 680], 'Invest.': [658, 681], '1992;': [659, 1405], '90:': [660], '1138-1144Google': [661], 'Scholar,': [662, 805, 5326], '4Kume': [663], 'transcriptionally': [669], 'gene': [673], '1994;': [682], '93:': [683], '907-911Google': [684], 'Scholar),': [685, 726, 1408, 4710, 4900], 'monocyte': [686], 'chemotaxis': [687], '(5Jing': [688], 'Q.': [689], 'Xin': [690], 'S.M.': [691], 'Zhang': [692], 'W.B.': [693], 'Wang': [694, 784], 'P.': [695, 990, 1142, 1447, 1656, 4236, 4804], 'Qin': [696], 'Y.W.': [697], 'Pei': [698], 'G.': [699, 865, 867, 996, 1008, 1010, 1022, 1028, 1148, 1160, 1162, 1174, 1180, 1960, 1974, 2084, 2090, 4242, 4254, 4256, 4268, 4274], 'activates': [701], 'p38': [702, 714], 'p42/44': [704], 'mitogen-activated': [705, 5345], 'protein': [706, 752], 'kinases': [707], 'monocytic': [709], 'THP-1': [710], 'cells,': [711, 1099, 5236], 'but': [712, 2481, 5422], 'only': [713], 'activation': [715, 729, 745, 759, 5278], 'its': [719, 845, 969, 3010, 4987, 5144, 5171], 'stimulated': [720], 'chemotaxis.Circ.': [721], 'Res.': [722, 1993], '87:': [724], '52-59Google': [725], 'macrophage': [728, 5243], '(6Yamamoto': [730], 'Homma': [732], 'S.': [733, 1004, 1026, 1156, 1178, 4250, 4272, 4347, 4723, 4806], 'Millman': [734], 'I.': [735, 994, 1146, 4240, 4686, 4735, 4818, 4873], 'Identification': [736], 'serum': [739, 4094, 4132, 4787], 'required': [741], 'macrophages.': [747], 'Role': [748], 'vitamin': [750], 'D3-binding': [751], '(group': [753], 'specific': [754, 1037, 1189, 2047, 3989, 4283], 'component,': [755], 'Gc)': [756], 'mouse': [761, 4772], 'peritoneal': [762], 'macrophages.J.': [763], 'Immunol.': [764, 801, 1043, 1195, 4289, 4962, 5322], '1991;': [765], '147:': [766], '273-280Google': [767], 'Moreover,': [769, 4443, 4763, 5276], 'has': [771, 853, 4847, 5042], 'implicated': [773], 'pathogenesis': [776], 'atherosclerosis': [778], 'autoimmune': [780, 5091, 5128], 'disease': [781, 4990], '(7Koh': [782], 'J.S.': [783, 787], 'Z.': [785, 5106], 'Levine': [786], 'Cytokine': [788], 'dysregulation': [789], 'induced': [790], 'apoptotic': [792], 'shared': [796], 'characteristic': [797, 3627, 3750], 'murine': [799], 'lupus.J.': [800], '165:': [803], '4190-4201Google': [804], '8Lusis': [806], 'A.J.': [807, 1014, 1166, 4260], 'Atherosclerosis.Nature.': [808], '407:': [810], '233-241Google': [811], 'Ceramide': [813, 881], '(Cer),': [814], 'initial': [816], 'breakdown': [817], 'product': [818, 4877], '(SPM),': [821], 'another': [823], 'example': [824], 'potential': [831, 3814, 3972], 'function.': [836], 'well-known': [840], 'intracellular': [841], 'second': [842], 'messenger,': [843], 'concentration': [846, 2797, 2832, 2984, 3006, 4173, 5168], 'identified': [855, 1679, 5045], 'possible': [858, 887, 1758, 2397, 3051, 4828], 'marker': [859, 888], 'predict': [861], 'multiorgan': [862], 'dysfunction': [863, 892], '(9Delogu': [864], 'Famularo': [866], 'Amati': [868], 'F.': [869, 1018, 1170, 4264], 'Signore': [870], 'L.': [871, 878], 'Antonucci': [872], 'A.': [873, 982, 984, 992, 1134, 1136, 1144, 1972, 4228, 4230, 4238, 4808, 4953, 5187], 'Trinchieri': [874], 'V.': [875, 4949], 'Di': [876], 'Marzio': [877], 'Cifone': [879], 'M.G.': [880], 'concentrations': [882, 3117, 4006, 4298, 4314, 5424], 'patients:': [885], 'syndrome.Crit.': [893], '1999;': [896, 1994], '27:': [897], '2413-2417Google': [898], 'also': [904, 1225, 3003, 3946, 4182, 5043, 5358, 5399], 'act': [905], 'an': [907, 1475, 2036, 4208, 4600, 4777, 5090, 5360], 'extracellular': [908, 4654, 4664], 'agonist.': [909], 'shows': [912], 'some': [913, 1105, 1957], 'structural': [914], 'similarity': [915], 'bacterial': [917, 3868, 3884], 'lipopolysaccharide': [918], '(LPS),': [919], 'known': [922, 5223], 'elicit': [924], 'responses': [927], 'can': [929, 4883], 'fatal': [932], 'humans': [936, 5009], '(10Wright': [937], 'S.D.': [938], 'Kolesnick': [939], 'R.N.': [940], 'Does': [941], 'endotoxin': [942], 'stimulate': [943, 5286], 'mimicking': [946], 'ceramide?.Immunol.': [947], 'Today.': [948], '1995;': [949], '16:': [950], '297-302Google': [951], 'We': [953], 'recently': [955, 4767], 'shown': [956, 2548, 2787, 2973, 3393, 3441, 3514, 4015, 4154, 4671, 5284], 'LPS': [964, 1059, 1073, 4784, 4926], 'receptor': [965, 1038, 1050, 1190, 4284, 4927, 5052, 5080, 5123], 'CD14': [966, 1034, 1076, 1186, 4280, 4928], 'clustering': [970, 1039, 1191, 4285, 4923, 4941], 'membrane': [973, 4931, 4957], 'proteins': [974, 4932], 'form': [976, 1730], 'multi-receptor': [978], 'signaling': [979], 'complex': [980, 4627, 5469], '(11Pfeiffer': [981, 1133, 4227], 'Bottcher': [983, 1135, 4229], 'Orso': [985, 1137, 4231], 'E.': [986, 1138, 4232, 4812, 4955], 'Kapinsky': [987, 1139, 4233], 'M.': [988, 1002, 1140, 1154, 1964, 4234, 4248], 'Nagy': [989, 1141, 4235], 'Bodnar': [991, 1143, 4237], 'Spreitzer': [993, 1145, 4239], 'Liebisch': [995, 1147, 4241], 'Drobnik': [997, 1149, 1961, 2085, 4243], 'W.': [998, 1150, 1962, 2086, 4244], 'Gempel': [999, 1151, 4245], 'K.': [1000, 1152, 4246, 5066], 'Horn': [1001, 1153, 4247], 'Holmer': [1003, 1155, 4249], 'Hartung': [1005, 1157, 4251], 'T.': [1006, 1158, 4252, 4863], 'Multhoff': [1007, 1159, 4253], 'Schutz': [1009, 1161, 4255], 'Schindler': [1011, 1163, 4257], 'H.': [1012, 1016, 1164, 1168, 4258, 4262, 4947], 'Ulmer': [1013, 1165, 4259], 'Heine': [1015, 1167, 4261], 'Stelter': [1017, 1169, 4263], 'Schutt': [1019, 1171, 4265], 'C.': [1020, 1172, 4266], 'Rothe': [1021, 1173, 4267], 'Szollosi': [1023, 1175, 4269], 'J.': [1024, 1042, 1176, 1194, 1933, 4270, 4288, 4816, 4861, 4867, 4951, 5350], 'Damjanovich': [1025, 1177, 4271], 'Schmitz': [1027, 1179, 1973, 2089, 4273], 'Lipopolysaccharide': [1029, 1181, 4275], 'docking': [1032, 1184, 4278], 'provokes': [1035, 1187, 4281], 'ligand-': [1036, 1188, 4282], 'rafts.Eur.': [1041, 1193, 4287], '2001;': [1044, 1196, 4290, 4367, 5082, 5130], '31:': [1045, 1197, 4291], '3153-3164Google': [1046, 1198, 4292], 'This': [1048, 3237, 4537], 'Cer-induced': [1049], 'cluster': [1051], 'partially': [1053], 'overlapping': [1054], 'formed': [1057], 'after': [1058, 1725, 1759, 1793, 1803, 3596, 3638, 3683, 3761, 4107, 4145, 4714], 'stimulation,': [1060], 'indicating': [1061], 'modulate': [1065], 'function,': [1068], 'part,': [1070], 'differentially': [1071], 'via': [1074], 'pathway.': [1077], 'present': [1083, 3374, 4150], 'plasma,': [1086], 'it': [1087, 3048], 'conceivable': [1089], 'regulatory': [1094], 'environment': [1095], 'patrolling': [1097], 'show': [1104], 'association': [1106, 4608, 5153, 5409], 'functionally': [1108], 'related': [1109, 3004, 3097, 3633, 3756], 'disorders.': [1110], 'Indeed,': [1111, 3299], 'pilot': [1114, 4225], 'small': [1118], 'number': [1119, 3932], 'subjects,': [1121], 'observed': [1123, 3127, 3257, 4296, 4478, 5152, 5408], 'certain': [1127], 'study,': [1203, 4151, 4584], 'addition': [1219, 2068, 2184], 'absolute': [1222, 3116, 5022], 'concentrations,': [1223], 'respective': [1232, 3133], 'molecules.': [1234], 'These': [1235, 3279], 'reflecting': [1237, 2901], 'generation': [1244, 4399], 'both': [1246, 3297, 4401, 4487], 'found': [1249, 2850, 4437, 4552], 'highly': [1253], 'respect': [1257, 3158], 'our': [1272, 4581, 5391], 'syndrome.': [1287, 2668, 2732, 5474], 'Approval': [1288], 'was': [1292, 1303, 1410, 1530, 1678, 1741, 1753, 1796, 1910, 2000, 2053, 2057, 2065, 2075, 2141, 2175, 2203, 2243, 2249, 2346, 2366, 2408, 2419, 2451, 2839, 2929, 2990, 3049, 3256, 3270, 3303, 3348, 3708, 3798, 3823, 4081, 4119, 4187, 4477, 4562, 4670, 5283], 'obtained': [1293, 1304, 1729], 'institutional': [1297], 'review': [1298, 5253], 'board,': [1299], 'informed': [1301], 'consent': [1302], 'included': [1308, 1342, 2429], 'study.': [1311], 'All': [1312, 1782, 4100, 4138], 'who': [1314, 3372], 'admitted': [1316], 'units': [1321], 'University': [1324], 'Hospital': [1325], 'Regensburg': [1327], 'between': [1328, 2351, 2534, 2890, 3069, 3081, 3178, 3287, 3296, 3558, 3586, 3835, 4045, 4086, 4124, 4416, 4461, 4651, 4830], 'October': [1329], '1999': [1330], 'July': [1332], '2001': [1333], 'evaluated': [1335], 'prospectively.': [1336], 'One': [1337, 2424], 'hundred': [1338, 2425], 'two': [1339, 1496, 1816, 2426, 4213, 4698], 'when': [1346, 3713, 3803], 'According': [1353], 'Consensus': [1356, 1393], 'Conference': [1357, 1394], 'Criteria': [1358], '(12Bone': [1359], 'R.C.': [1360], 'Balk': [1361], 'R.A.': [1362], 'Cerra': [1363], 'F.B.': [1364], 'Dellinger': [1365], 'R.P.': [1366], 'Fein': [1367], 'A.M.': [1368], 'Knaus': [1369], 'W.A.': [1370], 'Schein': [1371], 'R.M.': [1372], 'Sibbald': [1373], 'W.J.': [1374, 1923], 'Definitions': [1375], 'failure': [1380], 'guidelines': [1382], 'use': [1385], 'innovative': [1387], 'therapies': [1388], 'ACCP/SCCM': [1392], 'Committee.': [1395], 'American': [1396, 1453, 1662], 'College': [1397], 'Chest': [1399], 'Physicians/Society': [1400], 'Critical': [1402], 'Medicine.Chest.': [1404], '101:': [1406], '1644-1655Google': [1407], 'diagnosed': [1411], 'based': [1412, 3190], 'presence': [1415, 1687, 2949], 'least': [1418, 1479, 2609, 3565, 4503], 'three': [1419, 2522, 2610], 'simultaneous': [1427], 'identification': [1428], 'focal': [1430], 'clinical,': [1433], 'radiological,': [1434], 'or': [1435, 1562, 1586, 1594, 1628, 1649, 1717, 2620, 2626, 2633, 3071, 3083, 3121, 3326, 3858, 4004, 4055, 4340, 5436], 'microbiological': [1436], 'criteria.': [1437], 'Microbiological': [1438, 1669], 'cultures': [1439, 1618, 1670], 'done': [1441], 'according': [1442, 1651, 1912, 1950, 2329, 4219], 'standard': [1444, 1653, 2183], 'techniques': [1445], '(13Murray': [1446, 1655], 'Manual': [1448, 1657], 'Clinical': [1450, 1659], 'Microbiology.7th': [1451, 1660], 'edition.': [1452, 1661], 'Society': [1454, 1663], 'Microbiology,': [1456, 1665], 'Washington,': [1457, 1666], 'DC1999Google': [1458, 1667], 'Cultures': [1460], 'considered': [1462, 1505, 1610, 1635, 1672, 2409], '"positive"': [1463], 'case': [1466], 'a)': [1468], 'bacteremia,': [1469], 'organism': [1476, 1677], 'one': [1480, 1814], 'culture': [1482, 1589], 'bottle,': [1483], 'except': [1484], 'coagulase-negative': [1486, 1603], 'staphylococci': [1487, 1632], '(these': [1488], 'organisms': [1489, 1510, 1540, 1573, 1642], 'needed': [1490], 'grow': [1492], 'more': [1494, 3320], 'than': [1495, 1896], 'bottles': [1497], 'drawn': [1498, 1754], 'different': [1500, 1978, 2186, 2792, 2952, 3241, 3306, 3366, 4164, 5212], 'time': [1501, 1769, 2435, 3362, 3379, 3581], 'points': [1502, 3582], 'relevant).': [1506], 'b)': [1507], 'Growth': [1508, 1614], 'normally': [1512], 'sterile': [1513], 'body': [1514, 5201], 'sites/fluids/cavities': [1515], 'representing': [1516], 'focus': [1518], 'clinically-diagnosed': [1520], 'infection.': [1521], 'c)': [1522], 'Intra-abdominal': [1523], 'due': [1525, 5428], 'perforated': [1527], 'bowel,': [1528], 'always': [1531], 'classified': [1532, 1644], 'mixed': [1534, 2461], 'gram-positive/gram-negative': [1535], 'infection,': [1536], 'regardless': [1537], 'eventually': [1542], 'recovered': [1543], 'culture.': [1545], 'd)': [1546], 'Pulmonary': [1547], 'infiltrates': [1550], 'chest': [1552], 'X-ray,': [1553], 'pulmonary': [1558, 1611], 'pathogen': [1559], 'sputum': [1561], 'tracheal': [1563], 'aspirate': [1564], 'together': [1565], 'abundant': [1567, 1572], 'white': [1568, 2693, 2757], 'gram-stain': [1575], 'exhibiting': [1576], 'same': [1578, 2897, 4423], 'staining': [1579], 'characteristics': [1580], 'isolate': [1583], 'culture,': [1585], 'positive': [1588, 1596, 2042, 3523, 3576], 'bronchoalveolar': [1591], 'lavage': [1592], 'fluid,': [1593], 'legionella': [1597], 'antigen': [1598], 'test': [1599, 2345, 4080, 4118, 4492], 'urine.': [1601], 'Enterococci,': [1602], 'staphylococci,': [1604], 'Candida': [1606], 'spp.': [1607], 'not': [1609, 1634, 2585, 2881, 3026, 3050, 3209, 3400, 4377, 4457], 'pathogens.': [1612], 'e)': [1613], 'pathogens': [1616, 1636], 'taken': [1619, 1775], 'wounds': [1621], 'draining': [1623], 'pus,': [1624], 'fasciitis,': [1625], 'cellulitis,': [1626], 'sinusitis,': [1627], 'pelvic': [1629], 'infections.': [1630, 3869], 'Coagulase-negative': [1631], 'respect.': [1639], 'isolated': [1641], 'gram-negative,': [1646], 'gram-positive,': [1647], 'viral,': [1648, 2471], 'fungal': [1650], 'negative': [1673, 3525, 3549], 'if': [1674, 1695, 2488], 'no': [1675], 'relevant': [1676], 'despite': [1680], 'appropriate': [1681], 'sampling': [1682], 'specimens': [1684, 1703, 2496], 'above-mentioned': [1690], '(e.g.,': [1694, 2487], 'patient': [1697, 2352, 2490, 4087, 4125, 5383], 'had': [1698, 2491, 5297], 'received': [1699, 2492], 'antibiotic': [1700, 2493], 'therapy': [1701, 2494], 'before': [1702, 2495], 'sent': [1705, 2498], 'culture).': [1707, 2500], 'assigned': [1711], 'group': [1714, 1834, 3227], 'survivors': [1716, 2544, 3179, 3245, 3273], 'nonsurvivors,': [1718, 2515, 3229, 4558], 'depending': [1719], 'entry,': [1727], 'hospital': [1731], 'records.': [1732], 'Simplified': [1734, 3614, 3737], 'Acute': [1735, 3615, 3738, 4819], 'Physiology': [1736, 3616, 3739], 'Core': [1737, 3617, 3740], 'II': [1738, 2373, 3472, 3504, 3540, 3573], '(SAPS': [1739], 'II)': [1740], 'used': [1742, 2152, 2347, 2420, 3175, 4082, 4120], 'classify': [1744], 'severity': [1746], 'sample': [1752], 'soon': [1756], '(day': [1770, 3833, 4510], '1).': [1771], 'Subsequent': [1772], 'samples': [1773, 1784, 1807, 2823, 5384], '3': [1776, 3376], '10': [1779, 2413, 2528], 'thereafter.': [1781], 'immediately': [1786], 'delivered': [1787], 'central': [1790], 'laboratory': [1791], 'and,': [1792], 'centrifugation,': [1794], 'stored': [1797], '−80°C': [1799], '2': [1801, 2472, 2475], 'h': [1802], 'drawing.': [1805], 'Blood': [1806], 'clinical': [1809, 5448], 'records': [1810], 'missing': [1812], '(1.5%),': [1815], '(3%),': [1817], 'ten': [1819], '(15.8%)': [1820], 'surviving': [1821, 3235, 4462], '1,': [1825, 3214, 3309, 3485], '4,': [1827], '11,': [1830, 3547, 4023], 'respectively.': [1831, 2304, 3918, 4012], 'control': [1833, 2354, 2820, 2936], 'consisted': [1835], 'donors.': [1840], 'Bioactive': [1841], 'follows:': [1846], 'reagents,': [1847], 'methanol,': [1848], 'chloroform': [1850], 'HPLC': [1853], 'grade': [1854, 1871], 'Merck': [1858], '(Darmstadt,': [1859], 'Germany);': [1860], 'ammonium': [1861, 1864, 2021], 'acetate': [1862], 'formiate': [1865, 2022], 'highest': [1869], 'analytical': [1870], 'available': [1872], 'purchased': [1874], 'Fluka': [1876], '(Buchs,': [1877], 'Switzerland).': [1878], 'Cer,': [1879, 2222, 2294, 3193, 3729, 3787, 4615, 4669], 'PC,': [1880, 2134, 3075, 3100, 3619, 3703, 3742, 3793], 'SPM,': [1881, 2296, 3194, 3608, 3699, 3731, 3789], 'standards': [1884], 'Avati': [1888], 'Polar': [1889], 'Lipids': [1890], '(Alabaster,': [1891], 'AL)': [1892], 'purity': [1894], 'higher': [1895, 3271, 4467], '99%.': [1897], 'Quantification': [1898, 2064], 'spectrometry:': [1904], '20': [1905, 2019], 'μl': [1906], 'citrate': [1908], 'extracted': [1911], 'protocol': [1915], 'Bligh': [1917], 'Dyer': [1919, 1922], '(14Bligh': [1920], 'E.G.': [1921], 'A': [1924, 3253, 3813], 'rapid': [1925], 'method': [1926, 3024], 'extraction': [1930], 'purification.Can.': [1932], 'Biochem.': [1934], 'Phys.': [1935], '1959;': [1936], '37:': [1937], '911-917Google': [1938], 'quantified': [1943, 2076], 'electrospray': [1945, 1986, 2037, 2097], 'ionization': [1946, 1987, 2098], 'principle': [1953, 2388], 'described': [1954, 2078, 4595, 5035], 'previously,': [1955], 'modifications': [1958], '(15Liebisch': [1959], 'Reil': [1963], 'Trumbach': [1965], 'B.': [1966, 1970, 2088, 4800], 'Arnecke': [1967], 'R.': [1968, 4350, 4731], 'Olgemoller': [1969], 'Roscher': [1971], 'Quantitative': [1975], 'measurement': [1976], 'crude': [1982], 'cellular': [1983, 4688, 5229], 'extracts': [1984], '(ESI-MS/MS).J.': [1991], '40:': [1995], '1539-1546Google': [1996], 'Briefly,': [1998, 2107], 'direct-flow': [2003], 'injection': [2004, 4782], 'analysis': [2005, 2248, 2299, 2943, 3938], 'Waters': [2008], 'Alliance': [2009], '2790': [2010], '(Milford,': [2011], 'MA),': [2012], 'providing': [2013], 'constant': [2015], 'flow': [2016], 'methanol': [2018], 'mM': [2020], 'coupled': [2023], 'triple': [2026, 2199], 'quadrupole': [2027, 2200], 'spectrometer': [2029, 2202], '(Quattro': [2030], 'LC,': [2031], 'Micromass,': [2032], 'UK)': [2033], 'equipped': [2034], 'ion': [2038, 2043, 2049, 2269], 'source': [2039, 4745], 'operated': [2040, 2204], 'mode.': [2044], 'daughter': [2048], 'm/z': [2051, 2119, 2140], '264': [2052], 'used,': [2054], 'C17:0-Cer': [2056], 'utilized': [2058], 'not-naturally-occurring': [2061, 2121, 2145], 'internal': [2062, 2126, 2154], 'standard.': [2063], 'achieved': [2066, 2176], 'naturally': [2070, 2187], 'occurring': [2071, 2188], 'species.': [2073, 2816], 'separate': [2081], 'manuscript': [2082], '(16Liebisch': [2083], 'Lieser': [2087], 'High': [2091, 3474], 'throughput': [2092], 'quantification': [2093, 2130, 2170], 'spectrometry.Clin.': [2101], 'Chem.': [2102, 4706, 4758, 4896], '48:': [2104], '2217-2224Google': [2105], 'monitored': [2111], 'phosphocholine-specific': [2114], 'parent': [2115, 2136], 'scan': [2116, 2137], '184': [2118, 2139], 'using': [2120, 2314, 2376], 'C13:0-LPC': [2122], 'C19:0-LPC': [2124], 'standards.': [2127, 2155], 'For': [2128, 3641, 3764], 'SPM': [2132, 2159, 2893, 2928, 4419, 4434, 4667], 'applied': [2142, 3020], 'PC': [2146, 2157, 2298, 3013, 3046, 3197], 'C28:0-PC': [2148], 'C44:0-PC': [2150], 'Overlapping': [2156], 'isotope': [2160, 2167], 'corrected': [2163], 'theoretically': [2165], 'calculated': [2166, 2328], 'distribution.': [2168], 'phosphocholine-containing': [2173], 'calibration': [2178], 'lines': [2179], 'varying': [2190], 'chain': [2192], 'length': [2193], 'degree': [2195], 'unsaturation.': [2197], 'following': [2207, 2449, 2614], 'settings:': [2208], 'capillary': [2209], '3.5': [2210], 'kV,': [2211], 'cone': [2212], '41': [2213], 'V': [2214, 2220], 'PC-SPM': [2216], 'LPC,': [2218, 2295, 3195, 3610, 3701, 3733, 3791], '40': [2219], 'collision': [2223, 2227], 'energy': [2224], '24': [2225], 'V,': [2226], 'gas': [2228], '1.3': [2230], '10−3': [2231], 'Torr': [2232, 2238], 'argon': [2233], 'phospholipids,': [2235], '0.8': [2236], '10−4': [2237], 'Cer.': [2240], 'Mass': [2241], 'resolution': [2242], 'above': [2244, 2798], 'unit': [2245], 'resolution.': [2246], 'Data': [2247], 'performed': [2250], 'MassLynx': [2252], 'software,': [2253], 'NeoLynx': [2256, 2271], 'tool': [2257], '(Micromass),': [2258], 'averaging': [2260], 'scans': [2262], 'half-peak': [2264], 'height': [2265], 'count.': [2270], 'exported': [2274], 'Excel': [2276, 2283], 'spreadsheets': [2277], 'further': [2279, 3168, 3961, 4575], 'processed': [2280], 'self-programmed': [2282], 'macros.': [2284], 'intra-day': [2286], 'inter-day': [2288], 'coefficients': [2289], 'variation': [2291], '(CV)': [2292], '<5%': [2301], '<12%,': [2303], 'Total': [2305, 2552], 'cholesterol,': [2306, 2553, 2702, 2709, 2713, 2719, 2766, 2773, 2777, 2783, 4052, 4054], 'triglycerides,': [2307, 2705, 2769], 'HDL': [2309, 2718, 2782, 4025, 4051, 5419], 'cholesterol': [2310, 2647, 2653, 2659], '(HDL-C)': [2311], 'routine': [2315], 'methods': [2317], 'Bayer': [2320], 'ADVIA': [2321], '1650': [2322], 'analyzer.': [2323], 'LDL': [2324, 2712, 2776, 4027, 4053, 5421], 'VLDL': [2326, 2708, 2772, 4032, 4056, 5426], 'Friedewald': [2332], 'equation.': [2333], 'expressed': [2337, 2683, 2747, 5057], 'mean': [2339, 2685, 2749], '±': [2340, 2638, 2640, 2643, 2645, 2649, 2651, 2655, 2657, 2661, 2663, 2686, 2750, 3888, 3892, 3898, 3902, 3909, 3913], 'SE.': [2341, 2687, 2751], 'Mann-Whitney': [2343, 4116], 'unpaired': [2344, 4079, 4117], 'examine': [2349, 4084, 4122], 'differences': [2350, 3312, 3924, 4085, 4123], 'groups.': [2355, 3298], 'performance': [2357], 'predicting': [2363], 'SAPS': [2372, 3471, 3503, 3539, 3572, 3612, 3735], 'score': [2374, 3505], 'receiver': [2378, 3625, 3644, 3748, 3767, 5497], 'operating': [2379, 3626, 3645, 3749, 3768, 5498], 'curve': [2380, 3438, 5493, 5499], '(ROC)': [2381], 'approach.': [2382], 'ROC': [2383, 3420], 'curves': [2384, 3628, 3751], 'represent': [2385], 'graphically': [2386], 'spectrum': [2391], 'sensitivity-specificity': [2393], 'decision': [2398], 'thresholds': [2399], 'included.': [2401], 'tests,': [2404], 'P': [2405, 4096, 4134], '<': [2406], '0.05': [2407], 'significant.': [2410], 'SPSS': [2412], 'Windows': [2415], '(SPSS,': [2416], 'Inc.)': [2417], 'program': [2418], 'statistical': [2422, 2587, 2883], 'analysis.': [2423], 'regard': [2443, 3956], 'detected': [2446, 2803], 'microorganisms,': [2447, 3844], 'distribution': [2450], 'observed:': [2452], 'gram-positive': [2453, 2462, 3849, 3881], 'bacteria,': [2454, 2458, 2465], '32': [2455], 'patients;': [2456, 2460, 2467, 2470, 2473], 'gram-negative': [2457, 2464, 3859, 3883], '28': [2459], '13': [2466, 2469, 2524, 3866], 'fungi,': [2468], 'others,': [2474], 'Twelve': [2477], 'culture-negative': [2480], 'Within': [2501], 'days,': [2503, 2523, 2529], '39': [2504, 2514], '(38.2%)': [2506], 'died': [2507, 2518, 2526, 2533], 'because': [2508], 'reasons.': [2511], 'Of': [2512], '8': [2516], '19': [2531, 2662], '11': [2536, 3224, 3318, 3347, 3458, 3494, 4106, 4144], '30.': [2539], 'baseline': [2541], 'demographics': [2542, 2590], 'nonsurvivors': [2546, 2578, 3181, 3248, 3276], 'Table': [2550, 3443, 3516, 4017], '1.': [2551], 'HDL-C,': [2554, 4008], 'LDL-C': [2556, 2572], 'reduced': [2562, 2992], 'population.': [2567], 'HDL-C': [2570], 'tended': [2573], 'lower': [2576], 'survivors,': [2581, 4545], 'although': [2582, 3202], 'did': [2584, 2880, 3025, 3208], 'reach': [2586, 2882], 'significance.TABLE': [2588], '1Patient': [2589], 'entryVariableSurvivors': [2593], '(n': [2594, 2597, 3850, 3860], '=': [2595, 2598, 3851, 3861, 3895, 3905, 3916, 4062, 4065, 4068, 4071, 4074, 4077], '63)Nonsurvivors': [2596], '39)Age,': [2599], 'years,': [2600], 'mean53.8': [2601], '(range:': [2602, 2604], '20–91)54.9': [2603], '17–80)Gender': [2605], 'F/M20/4311/28Patients': [2606], 'out': [2611], 'four': [2615, 2955], 'SIRS': [2616], 'criteria6339Rectal': [2617], 'temperature': [2618], '>38°C': [2619], '<36°C4532White': [2621], 'count': [2624], '>12/nl': [2625], '<4/nl5633Heart': [2627], 'rate': [2628, 2631], '>90': [2629], 'beats/min5536Respiratory': [2630], '>20/min': [2632], 'assisted': [2634], 'ventilation6338Lipid': [2635], 'valuesCholesterol': [2636], '(mg/dl)91': [2637], '585': [2639], '9Triglycerides': [2641], '(mg/dl)207': [2642], '20236': [2644], '28VLDL': [2646], '(mg/dl)41': [2648], '447': [2650], '6LDL': [2652], '(mg/dl)38': [2654], '429': [2656], '6HDL': [2658], '(mg/dl)12': [2660], '1SIRS,': [2664], 'Except': [2669, 2733], 'age': [2671, 2735], 'lipoprotein': [2673, 2737, 3990, 4093, 4131], 'values,': [2674, 2738, 2821, 3521], 'numbers': [2677, 2741, 4577], 'Normal': [2688, 2752], 'values:': [2689, 2753], 'rectal': [2690, 2754], 'temperature,': [2691, 2755], '36.5–37.4°C;': [2692, 2756], 'count,': [2696, 2760], '4.8–10.8/nl;': [2697, 2761], 'heart': [2698, 2762], 'rate,': [2699, 2763], '60–75': [2700, 2764], 'beats/min;': [2701, 2765], '<200': [2703, 2706, 2767, 2770], 'mg/dl;': [2704, 2707, 2711, 2768, 2771, 2775], '<40': [2710, 2774], '<150': [2714, 2778], 'mg': [2715, 2779], 'dl;': [2716, 2780], '35–68': [2720, 2784], 'mg/dl.': [2721, 2785], 'Open': [2722, 3664, 3723, 4110], 'table': [2723, 3665, 3724, 4111], 'new': [2726, 3668, 3727, 4114], 'tab': [2727, 3669, 3728, 4115], 'SIRS,': [2728], 'As': [2786, 2859, 2972, 4404], 'Fig.': [2789, 2975], '1A,': [2790], 'eight': [2791], '0.1': [2799], 'μmol/l': [2800], 'could': [2801, 3104, 3173, 4376, 5149], 'controls,': [2808, 4555], 'C24:0': [2810], 'C24:1': [2812, 2838], 'major': [2815], 'Compared': [2817], 'differences.': [2829, 3974], 'Whereas': [2830, 4466], 'significantly': [2840, 2910, 3210, 3240, 3305, 3460, 3479, 4163, 4459], 'C24:0-Cer': [2845], 'C23:0-Cer': [2847], '(Fig.': [2857, 2915, 2938, 3142, 3277, 3329], '1A).': [2858], 'consequence': [2861], 'inverse': [2864, 4209, 4484, 5014], 'changes,': [2865], 'increase': [2867, 4673], 'Cers': [2870], '(representing': [2874], 'sum': [2876, 3088, 3715, 3805], 'species)': [2879], 'significance.': [2884, 4099, 4137], 'contrast,': [2886, 4194], 'N-linked': [2898, 4424], 'acyl': [2899, 3035, 4425], 'group,': [2900], 'reaction': [2904], 'formation,': [2908], '1B).': [2916, 2939], 'Similarly,': [2917], 'ratio': [2920, 3269, 3286, 3302, 3536, 4435], 'elevated': [2931, 4439], 'Tandem': [2940], 'spectrometric': [2942], 'revealed': [2947, 3153], '12': [2951], 'species;': [2953], 'however,': [2954, 3928], 'species,': [2956, 2989, 3125, 4179, 4215], 'i.e.,': [2957], 'C16:0,': [2958], 'C18:0,': [2959], 'C18:1,': [2960], 'C18:2,': [2962], 'account': [2963], 'over': [2965], '90%': [2966], 'concentration.': [2971], '2A,': [2976], 'concentration,': [2979], 'main': [2987, 3123, 4176, 4214], 'Similar': [2997, 3113], 'ratio,': [3001, 3261, 4447, 4500], 'molecule': [3012, 5250], 'basis.': [3017], 'allow': [3027], 'discrimination': [3028], 'molecular': [3031], 'masses': [3032], 'chains': [3036], 'sn-1': [3039], 'sn-2': [3042], 'position': [3043], 'molecule,': [3047], 'calculate': [3053], 'directly': [3058, 4379], 'corresponding': [3059, 3419], 'pairs.': [3062], 'Instead,': [3063], 'C16:0-': [3070], 'C18:0-LPC': [3072], 'C18:1': [3082], 'C18:2': [3084], 'unsaturated': [3091, 3107], 'PCs.': [3092], 'Saturated': [3093], 'since': [3101, 4901], 'saturated': [3102, 3111], 'arise': [3105], 'PC.': [3112], 'decrease': [3130], '2B).': [3143], 'comparison': [3146], 'substantial': [3154], 'differences,': [3155], 'especially': [3156], 'LPC-PC,': [3166, 3412, 3996, 4390], 'investigated': [3169, 3824], 'whether': [3170, 3979, 5406], 'discriminate': [3177, 3295], 'Thereby,': [3184], 'focused': [3186], 'concentrations.': [3198, 4095, 4133], 'Figure': [3199], '3Ashows': [3200], 'that,': [3201, 4543, 4769], 'differ': [3211], 'progressively': [3217], 'declined': [3232], 'group.': [3236], 'resulted': [3238], 'on.': [3252], 'similar': [3254, 3389, 3532], 'finding': [3255, 4978], 'important': [3264], 'difference': [3265], '3B).': [3278], 'oppositional': [3280], 'changes': [3281, 3352], 'suggested': [3282], 'calculating': [3284], 'help': [3292], 'better': [3294], '(Cer-SPM)-(LPC-PC)': [3301, 3414, 3475, 3535, 3876, 3998, 4499], 'already': [3304, 3478, 4566], 'pronounced': [3321], '3C).': [3330], 'exclude': [3334], 'possibility': [3336], 'increasing': [3339, 4576], 'discriminatory': [3340, 4527], '1': [3344, 3444, 3530], 'biased': [3349], 'mortality-induced': [3351], 'population,': [3356], 'separately': [3359], 'course': [3363], 'those': [3370], 'where': [3373], 'days.': [3377], 'kinetics': [3380], 'subpopulation': [3387], 'complete': [3396], 'population': [3398], '(data': [3399, 4456], 'shown).': [3401], 'investigate': [3405, 3978], 'value': [3408, 3712, 3802, 4495], 'Cer-SPM,': [3411, 3995], 'ratios,': [3415, 3872, 3874, 4573], 'prediction': [3422, 3630, 3753], 'entry': [3431, 3685, 3832], '(Table': [3432, 3506], '2).': [3433, 3507], 'area': [3435, 3622, 3745, 5490], 'under': [3436, 3623, 3746, 5491], '(AUC)': [3439], 'high': [3447, 3651, 3774, 4003, 4031, 4048, 4090, 4128, 5423], 'low': [3450, 3647, 3770, 3931, 4005, 4024, 4050, 4092, 4130, 5155, 5416], 'mortality,': [3463], 'AUCs': [3465, 3488], 'comparable': [3466], 'score.': [3473, 3541, 3574], 'discriminative': [3497], 'slightly': [3499], 'superior': [3500], 'Statistical': [3508], 'evaluation': [3509, 3950], 'powers': [3512], '3.': [3517], 'At': [3518, 3542], 'optimal': [3519, 3687], 'cutoff': [3520, 3688], 'molar-lipid': [3555, 3982], 'ranged': [3557], '0.792': [3559], '0.968,': [3561], 'good': [3567], '∼0.50.TABLE': [3584], '2Association': [3585], 'entryDayVariableAssociation': [3598], 'Mortaility': [3600], 'AUC95%': [3601], 'Confidence': [3602], 'IntervalSurvivor/NonsurvivorP1SAPS': [3603], 'II0.6760.512–0.73962/390.003Cer-SPM0.5960.484–0.70962/390.104LPC-PC0.5960.479–0.71262/390.106(Cer-SPM)-(LysoPC/PC)0.6290.518–0.74162/390.0294SAPS': [3604], 'II0.7230.607–0.83957/310.001Cer-SPM0.6870.573–0.80161/310.003LPC-PC0.6950.579–0.81161/310.002(Cer-SPM)-(LPC-PC)0.7430.635–0.85161/310.00011SAPS': [3605], 'II0.7950.649–0.88649/160.001Cer-SPM0.8180.709–0.92753/190.000LPC-PC0.7760.670–0.88153/190.000(Cer-SPM)-(LysoPC-PC)0.8290.735–0.92453/190.000Cer,': [3606], 'ceramide;': [3607, 3698, 3730, 3788], 'sphingomyelin;': [3609, 3700, 3732, 3790], 'lysophosphatidylcholine;': [3611, 3702, 3734, 3792], 'II,': [3613, 3736], 'II;': [3618, 3741], 'phosphatidylcholine;': [3620, 3743], 'AUC,': [3621, 3744], 'sepsis-': [3632, 3755], 'calculation': [3642, 3765], 'curve,': [3646, 3769], 'variables': [3656, 3779], 'assumed': [3658, 3781], 'TABLE': [3670], '3Predictive': [3671], 'levelsDayVariableCutoff': [3689], 'ValueSensitivitySpecificityPositive': [3690], 'Predictive': [3691, 3693], 'ValueNegative': [3692], 'Value1(Cer-SPM)-(LPC-PC)≥0.64570.6150.7260.5810.753SAPS': [3694], 'II≥51.50.5900.7580.6010.7494(Cer-SPM)-(LPC-PC)≥0.55780.7740.6890.5580.857Cer-SPM≥0.02240.7740.6070.5000.841LPC/PC≤0.04000.6450.6890.5130.792SAPS': [3695], 'II≥51.50.5810.8770.7160.79611(Cer-SPM)-(LPC-PC)≥0.51550.8420.7550.5520.930Cer-SPM≥0.02030.9470.6980.5290.973LPC/PC≤0.05530.9470.5850.4500.968SAPS': [3696], 'II≥43.00.8130.7760.5420.927Cer,': [3697], 'phosphatidylcholine.': [3704, 3794], 'Optimal': [3705, 3795], 'cut': [3706, 3796], 'off': [3707, 3797], 'defined': [3709, 3799, 3840], 'specificity': [3717, 3807], 'sensitivity': [3719, 3809], 'reached': [3720, 3810], 'maximum.': [3722, 3812], 'influence': [3815], 'microorganisms': [3819], 'alterations': [3822], 'comparing': [3826], '1)': [3834], 'largest': [3837], 'subgroups': [3838, 4589], 'e.g.,': [3845], 'either': [3848], '32;': [3852], '18': [3853], 'survivor': [3854, 3864], '14': [3856], 'nonsurvivor)': [3857, 3867], '28;': [3862], '15': [3863], 'infections': [3885], '0.025': [3887, 3891], '0.002': [3889, 3893], 'versus': [3890, 3900, 3911], '(P': [3894, 3904, 3915], '0.885),': [3896], '0.059': [3897], '0.005': [3899], '0.044': [3901], '0.004': [3903], '0.024),': [3906], '0.532': [3908], '0.071': [3910], '0.838': [3912], '0.128': [3914], '0.095),': [3917], 'Based': [3919, 5134], 'data,': [3922, 5137], 'microorganism-specific': [3923], 'present;': [3927], 'relatively': [3930], 'individuals': [3934], 'subgroup': [3937], 'limits': [3939], 'interpretation': [3941], 'prevents': [3947], 'valid': [3949], 'ongoing': [3965, 4582], 'will': [3967, 5398], 'necessary': [3969], 'establish': [3971], 'microorganism-dependent': [3973], 'correlate': [3987, 4034], 'profiles,': [3991], 'LDL-C,': [4009], 'VLDL-C,': [4011], 'demonstrate': [4019], 'prognostic': [4036], 'unfavorable': [4037, 4635, 5411], 'ratios.TABLE': [4039], '4Comparison': [4040], 'cholesterolLipoproteinCer-SPMLysoPC-PC(Cer-SPM)-(LPC-PC)MeanSEMeanSEPMeanSEPMeanSEPmg/dlmolar': [4057], 'ratiomolar': [4058, 4059], 'ratioHDLLow,': [4060], 'n': [4061, 4064, 4067, 4070, 4073, 4076], '386.60.50.02700.00150.04150.00390.97520.1281High,': [4063], '3420.20.90.01740.00090.0000.07560.00470.0000.28080.03060.000LDLLow,': [4066], '3929.74.20.02590.00150.04490.00420.89270.1238High,': [4069], '33108.15.80.01840.00110.0000.07260.00520.0000.35730.06830.000VLDLLow,': [4072], '3727.91.10.01820.00110.06740.00470.38280.0638High,': [4075], '3572.55.80.02690.00160.0000.04720.00510.0030.92690.13600.000Mann-Whitney': [4078], 'level': [4097, 4135], 'controls.': [4171], 'consequently': [4181], 'level,': [4186], 'tendency': [4200], 'toward': [4201, 4549, 5402], 'behavior': [4210], 'C24:1-': [4216], 'C24:0-Cer,': [4218], 'previous': [4221], 'However,': [4294, 4605, 4916, 5040], 'clearly': [4311], 'exceed': [4312], 'reported': [4317], 'induce': [4319, 4922, 5225], 'biological': [4320], 'artificial': [4323], 'plasma-free': [4324], 'conditions.': [4325], 'fraction': [4329, 4375], 'located': [4335], 'biologically': [4337], 'inactive': [4338], 'lipoprotein-': [4339], 'albumin-associated': [4341], 'pools': [4342], '(17Vuong': [4343], 'T.D.': [4344], 'de': [4345, 4348], 'Kimpe': [4346], 'Roos': [4349], 'Rabelink': [4351], 'T.J.': [4352], 'Koomans': [4353], 'H.A.': [4354], 'Joles': [4355], 'J.A.': [4356], 'Albumin': [4357], 'restores': [4358], 'lysophosphatidylcholine-induced': [4359], 'inhibition': [4360], 'vasodilation': [4362], 'rat': [4364], 'aorta.Kidney': [4365], 'Int.': [4366], '60:': [4368], '1088-1096Google': [4369], 'actually': [4373], 'active': [4374], 'detected,': [4380], 'additionally': [4382], 'lipids.': [4403, 5442], 'indicated': [4405], 'enhanced': [4408, 5172], 'formation': [4410, 5439], 'moiety': [4426], 'consistently': [4438], 'Cer-to-SPM': [4446], 'individual': [4454], 'shown)': [4458], 'discriminated': [4460], 'nonsurviving': [4464], 'predicted': [4471], 'worse': [4473], 'outcome,': [4474], 'opposite': [4476, 4560, 5299], 'ratio.': [4482], 'behaviors': [4485], 'markers': [4488], 'led': [4489], 'us': [4490], 'combined': [4498], 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