Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2062717502', 'doi': 'https://doi.org/10.1016/j.bbrc.2008.10.059', 'title': 'Islet alpha cell number is maintained in microencapsulated islet transplantation', 'display_name': 'Islet alpha cell number is maintained in microencapsulated islet transplantation', 'publication_year': 2008, 'publication_date': '2008-12-01', 'ids': {'openalex': 'https://openalex.org/W2062717502', 'doi': 'https://doi.org/10.1016/j.bbrc.2008.10.059', 'mag': '2062717502', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18950602'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.bbrc.2008.10.059', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151589183', 'display_name': 'Biochemical and Biophysical Research Communications', 'issn_l': '0006-291X', 'issn': ['0006-291X', '1090-2104'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5046688189', 'display_name': 'Sara Bohman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I123387679', 'display_name': 'Uppsala University', 'ror': 'https://ror.org/048a87296', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I123387679']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Sara Bohman', 'raw_affiliation_strings': ['Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.', 'institution_ids': ['https://openalex.org/I123387679']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5052351245', 'display_name': 'Aileen King', 'orcid': 'https://orcid.org/0000-0001-5759-7985'}, 'institutions': [{'id': 'https://openalex.org/I183935753', 'display_name': "King's College London", 'ror': 'https://ror.org/0220mzb33', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I183935753']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Aileen J F King', 'raw_affiliation_strings': ["Beta Cell Development and Function Group, Division of Reproduction and Endocrinology, Hodgkin Building 2.4N, Guy's Campus, King's College, London SE1 1UL, UK. Electronic address: [email protected]."], 'affiliations': [{'raw_affiliation_string': "Beta Cell Development and Function Group, Division of Reproduction and Endocrinology, Hodgkin Building 2.4N, Guy's Campus, King's College, London SE1 1UL, UK. Electronic address: [email protected].", 'institution_ids': ['https://openalex.org/I183935753']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2770, 'currency': 'USD', 'value_usd': 2770, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.454, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 19, 'citation_normalized_percentile': {'value': 0.821575, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 88, 'max': 89}, 'biblio': {'volume': '377', 'issue': '2', 'first_page': '729', 'last_page': '733'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10839', 'display_name': 'Pancreatic Islet Dysfunction and Regeneration', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10839', 'display_name': 'Pancreatic Islet Dysfunction and Regeneration', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10560', 'display_name': 'Management of Diabetes Mellitus and Hypoglycemia', 'score': 0.9879, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10414', 'display_name': 'Endocannabinoid System and Its Effects on Health', 'score': 0.9725, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/islet-transplantation', 'display_name': 'Islet Transplantation', 'score': 0.660552}, {'id': 'https://openalex.org/keywords/islet-cell-transplantation', 'display_name': 'Islet cell transplantation', 'score': 0.59345096}, {'id': 'https://openalex.org/keywords/alpha', 'display_name': 'Alpha (finance)', 'score': 0.51372087}, {'id': 'https://openalex.org/keywords/continuous-glucose-monitoring', 'display_name': 'Continuous Glucose Monitoring', 'score': 0.502238}, {'id': 'https://openalex.org/keywords/alpha-cell', 'display_name': 'Alpha cell', 'score': 0.45895275}], 'concepts': [{'id': 'https://openalex.org/C165220095', 'wikidata': 'https://www.wikidata.org/wiki/Q207524', 'display_name': 'Islet', 'level': 3, 'score': 0.93774843}, {'id': 'https://openalex.org/C2911091166', 'wikidata': 'https://www.wikidata.org/wiki/Q106419912', 'display_name': 'Transplantation', 'level': 2, 'score': 0.8380077}, {'id': 'https://openalex.org/C2778563252', 'wikidata': 'https://www.wikidata.org/wiki/Q170617', 'display_name': 'Glucagon', 'level': 3, 'score': 0.8118738}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.6604055}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6346493}, {'id': 'https://openalex.org/C2776828364', 'wikidata': 'https://www.wikidata.org/wiki/Q1767180', 'display_name': 'Beta cell', 'level': 4, 'score': 0.6027982}, {'id': 'https://openalex.org/C2777411314', 'wikidata': 'https://www.wikidata.org/wiki/Q1664517', 'display_name': 'Islet cell transplantation', 'level': 4, 'score': 0.59345096}, {'id': 'https://openalex.org/C2779306644', 'wikidata': 'https://www.wikidata.org/wiki/Q2002370', 'display_name': 'Insulin', 'level': 2, 'score': 0.5460113}, {'id': 'https://openalex.org/C64943373', 'wikidata': 'https://www.wikidata.org/wiki/Q2651003', 'display_name': 'Alpha (finance)', 'level': 4, 'score': 0.51372087}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.4850918}, {'id': 'https://openalex.org/C2777300450', 'wikidata': 'https://www.wikidata.org/wiki/Q2995031', 'display_name': 'Alpha cell', 'level': 5, 'score': 0.45895275}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.43395874}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.40323132}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.37276006}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.2659715}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.09752011}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.055142283}, {'id': 'https://openalex.org/C49453240', 'wikidata': 'https://www.wikidata.org/wiki/Q1592163', 'display_name': 'Construct validity', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C2775944032', 'wikidata': 'https://www.wikidata.org/wiki/Q22907659', 'display_name': 'Patient satisfaction', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003921', 'descriptor_name': 'Diabetes Mellitus, Experimental', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': True}, {'descriptor_ui': 'D003922', 'descriptor_name': 'Diabetes Mellitus, Type 1', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': True}, {'descriptor_ui': 'D050416', 'descriptor_name': 'Glucagon-Secreting Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D050417', 'descriptor_name': 'Insulin-Secreting Cells', 'qualifier_ui': 'Q000637', 'qualifier_name': 'transplantation', 'is_major_topic': True}, {'descriptor_ui': 'D050417', 'descriptor_name': 'Insulin-Secreting Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D016381', 'descriptor_name': 'Islets of Langerhans Transplantation', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001786', 'descriptor_name': 'Blood Glucose', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002214', 'descriptor_name': 'Capsules', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002452', 'descriptor_name': 'Cell Count', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D003921', 'descriptor_name': 'Diabetes Mellitus, Experimental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003921', 'descriptor_name': 'Diabetes Mellitus, Experimental', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D003921', 'descriptor_name': 'Diabetes Mellitus, Experimental', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': False}, {'descriptor_ui': 'D003922', 'descriptor_name': 'Diabetes Mellitus, Type 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003922', 'descriptor_name': 'Diabetes Mellitus, Type 1', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': False}, {'descriptor_ui': 'D003922', 'descriptor_name': 'Diabetes Mellitus, Type 1', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D005934', 'descriptor_name': 'Glucagon', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005934', 'descriptor_name': 'Glucagon', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D050416', 'descriptor_name': 'Glucagon-Secreting Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006943', 'descriptor_name': 'Hyperglycemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006943', 'descriptor_name': 'Hyperglycemia', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D006943', 'descriptor_name': 'Hyperglycemia', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D006943', 'descriptor_name': 'Hyperglycemia', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D050417', 'descriptor_name': 'Insulin-Secreting Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016381', 'descriptor_name': 'Islets of Langerhans Transplantation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.bbrc.2008.10.059', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151589183', 'display_name': 'Biochemical and Biophysical Research Communications', 'issn_l': '0006-291X', 'issn': ['0006-291X', '1090-2104'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18950602', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.61, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 28, 'referenced_works': ['https://openalex.org/W1698216789', 'https://openalex.org/W1968448831', 'https://openalex.org/W1982407587', 'https://openalex.org/W1984541901', 'https://openalex.org/W1987417071', 'https://openalex.org/W1992594198', 'https://openalex.org/W1996997425', 'https://openalex.org/W1998944797', 'https://openalex.org/W2022282748', 'https://openalex.org/W2060275191', 'https://openalex.org/W2069922907', 'https://openalex.org/W2071475464', 'https://openalex.org/W2084051615', 'https://openalex.org/W2097877954', 'https://openalex.org/W2110753158', 'https://openalex.org/W2116345973', 'https://openalex.org/W2124041514', 'https://openalex.org/W2125570430', 'https://openalex.org/W2126775244', 'https://openalex.org/W2127825630', 'https://openalex.org/W2133186034', 'https://openalex.org/W2146415791', 'https://openalex.org/W2160028030', 'https://openalex.org/W2166913319', 'https://openalex.org/W2328786770', 'https://openalex.org/W2443181206', 'https://openalex.org/W330955287', 'https://openalex.org/W4243202999'], 'related_works': ['https://openalex.org/W4376871275', 'https://openalex.org/W3177037827', 'https://openalex.org/W2418470975', 'https://openalex.org/W2372962057', 'https://openalex.org/W2288478759', 'https://openalex.org/W2146415791', 'https://openalex.org/W2070431852', 'https://openalex.org/W2062717502', 'https://openalex.org/W2062287675', 'https://openalex.org/W145060107'], 'abstract_inverted_index': {'Islet': [0], 'transplantation': [1, 14], 'can': [2, 125], 'reverse': [3], 'hyperglycaemia': [4], 'in': [5, 12, 67, 119, 135], 'Type': [6], '1': [7], 'diabetes': [8], 'patients.': [9], 'One': [10], 'problem': [11], 'islet': [13, 85], 'is': [15, 40], 'a': [16], 'loss': [17, 39, 130], 'of': [18, 45, 60, 79, 92, 100, 131], 'beta': [19, 132], 'cell': [20, 38, 117, 144], 'mass': [21], 'as': [22, 24, 105], 'well': [23], 'blunted': [25], 'glucagon': [26, 80, 110], 'responses': [27], 'from': [28], 'the': [29, 46, 50, 54, 71, 77, 90, 101], 'grafted': [30], 'islets.': [31], 'It': [32], 'has': [33], 'been': [34], 'suggested': [35], 'that': [36, 116], 'alpha': [37, 47, 143], 'associated': [41], 'with': [42, 49, 70], 'close': [43], 'contact': [44, 69], 'cells': [48, 81, 94], 'implantation': [51, 73], 'organ.': [52], 'In': [53], 'present': [55], 'study': [56], 'we': [57], 'made': [58], 'use': [59], 'microencapsulation,': [61], 'where': [62], 'transplanted': [63, 120], 'islets': [64, 102, 122], 'are': [65], 'not': [66], 'direct': [68], 'host': [72], 'site.': [74], 'After': [75], 'transplantation,': [76], 'number': [78, 91, 118, 145], 'stained': [82, 95], 'per': [83], 'microencapsulated': [84, 121], 'section': [86], 'was': [87, 96, 103, 106, 112], 'increased': [88], 'whereas': [89, 109], 'insulin': [93, 107], 'decreased.': [97], 'DNA': [98], 'content': [99, 111], 'reduced,': [104], 'content,': [108], 'unchanged.': [113], 'This': [114], 'indicates': [115], 'diminishes,': [123], 'which': [124], 'be': [126, 148], 'accounted': [127], 'for': [128], 'by': [129], 'cells.': [133], 'However,': [134], 'contrast': [136], 'to': [137, 147], 'previous': [138], 'studies': [139], 'using': [140], 'non-encapsulated': [141], 'islets,': [142], 'seems': [146], 'maintained.': [149]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2062717502', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-09-09T16:06:34.076122', 'created_date': '2016-06-24'}