Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2062296662', 'doi': 'https://doi.org/10.1002/pbc.20805', 'title': 'Survivin: An inhibitor of apoptosis in pediatric cancer', 'display_name': 'Survivin: An inhibitor of apoptosis in pediatric cancer', 'publication_year': 2006, 'publication_date': '2006-03-13', 'ids': {'openalex': 'https://openalex.org/W2062296662', 'doi': 'https://doi.org/10.1002/pbc.20805', 'mag': '2062296662', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16534789'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/pbc.20805', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119714264', 'display_name': 'Pediatric Blood & Cancer', 'issn_l': '1545-5009', 'issn': ['1545-5009', '1545-5017'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5002952095', 'display_name': 'Jason Fangusaro', 'orcid': 'https://orcid.org/0000-0003-3099-5259'}, 'institutions': [{'id': 'https://openalex.org/I71278862', 'display_name': 'Community College of Rhode Island', 'ror': 'https://ror.org/0104cy831', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I71278862']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jason R Fangusaro', 'raw_affiliation_strings': ["Center for Childhood Cancer, Columbus Children's Research Institute (CCRI), Columbus, Ohio 43205, USA."], 'affiliations': [{'raw_affiliation_string': "Center for Childhood Cancer, Columbus Children's Research Institute (CCRI), Columbus, Ohio 43205, USA.", 'institution_ids': ['https://openalex.org/I71278862']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018181569', 'display_name': 'Hugo Caldas', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hugo Caldas', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051954215', 'display_name': 'Yuying Jiang', 'orcid': 'https://orcid.org/0000-0002-3263-7730'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yuying Jiang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5064734839', 'display_name': 'Rachel A. Altura', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Rachel A Altura', 'raw_affiliation_strings': [], 'affiliations': []}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4330, 'currency': 'USD', 'value_usd': 4330, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.116, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 32, 'citation_normalized_percentile': {'value': 0.42264, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '47', 'issue': '1', 'first_page': '4', 'last_page': '13'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10294', 'display_name': 'Molecular Mechanisms of Apoptosis and Cell Death', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10294', 'display_name': 'Molecular Mechanisms of Apoptosis and Cell Death', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12226', 'display_name': 'Neuroblastoma Research and Treatment', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11914', 'display_name': 'Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/survivin', 'display_name': 'Survivin', 'score': 0.99307126}, {'id': 'https://openalex.org/keywords/inhibitor-of-apoptosis', 'display_name': 'Inhibitor of apoptosis', 'score': 0.8407401}, {'id': 'https://openalex.org/keywords/blood-cancer', 'display_name': 'Blood cancer', 'score': 0.5172982}, {'id': 'https://openalex.org/keywords/cancer-therapy', 'display_name': 'Cancer Therapy', 'score': 0.482107}, {'id': 'https://openalex.org/keywords/pediatric-cancer', 'display_name': 'Pediatric cancer', 'score': 0.446849}], 'concepts': [{'id': 'https://openalex.org/C2775975398', 'wikidata': 'https://www.wikidata.org/wiki/Q906904', 'display_name': 'Survivin', 'level': 3, 'score': 0.99307126}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.88221323}, {'id': 'https://openalex.org/C2777408456', 'wikidata': 'https://www.wikidata.org/wiki/Q174299', 'display_name': 'Inhibitor of apoptosis', 'level': 4, 'score': 0.8407401}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.64244056}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.6224152}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.5916525}, {'id': 'https://openalex.org/C2992972558', 'wikidata': 'https://www.wikidata.org/wiki/Q2509220', 'display_name': 'Blood cancer', 'level': 3, 'score': 0.5172982}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.49534145}, {'id': 'https://openalex.org/C2993561819', 'wikidata': 'https://www.wikidata.org/wiki/Q5097977', 'display_name': 'Pediatric cancer', 'level': 3, 'score': 0.446849}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.37700316}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.2797935}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.13907814}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.0891206}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D051034', 'descriptor_name': 'Inhibitor of Apoptosis Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008869', 'descriptor_name': 'Microtubule-Associated Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002648', 'descriptor_name': 'Child', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051034', 'descriptor_name': 'Inhibitor of Apoptosis Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051034', 'descriptor_name': 'Inhibitor of Apoptosis Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008869', 'descriptor_name': 'Microtubule-Associated Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008869', 'descriptor_name': 'Microtubule-Associated Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020033', 'descriptor_name': 'Protein Isoforms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020033', 'descriptor_name': 'Protein Isoforms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077022', 'descriptor_name': 'Survivin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/pbc.20805', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119714264', 'display_name': 'Pediatric Blood & Cancer', 'issn_l': '1545-5009', 'issn': ['1545-5009', '1545-5017'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16534789', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.63}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 101, 'referenced_works': ['https://openalex.org/W1484057906', 'https://openalex.org/W1492587973', 'https://openalex.org/W1514248240', 'https://openalex.org/W1540060031', 'https://openalex.org/W1543855321', 'https://openalex.org/W1662899239', 'https://openalex.org/W1961680179', 'https://openalex.org/W1965336678', 'https://openalex.org/W1965682168', 'https://openalex.org/W1966176339', 'https://openalex.org/W1966783510', 'https://openalex.org/W1967065056', 'https://openalex.org/W1968262266', 'https://openalex.org/W1968574304', 'https://openalex.org/W1969299292', 'https://openalex.org/W1972304655', 'https://openalex.org/W1975805869', 'https://openalex.org/W1976457595', 'https://openalex.org/W1979177187', 'https://openalex.org/W198605181', 'https://openalex.org/W1992892839', 'https://openalex.org/W1994650857', 'https://openalex.org/W1995257401', 'https://openalex.org/W1995484601', 'https://openalex.org/W1997062019', 'https://openalex.org/W2000215602', 'https://openalex.org/W2001742604', 'https://openalex.org/W2003808022', 'https://openalex.org/W2004304045', 'https://openalex.org/W2006613051', 'https://openalex.org/W2007010211', 'https://openalex.org/W2007811248', 'https://openalex.org/W2007931030', 'https://openalex.org/W2011329576', 'https://openalex.org/W2011865418', 'https://openalex.org/W2012892770', 'https://openalex.org/W2013762121', 'https://openalex.org/W2016634299', 'https://openalex.org/W2021588616', 'https://openalex.org/W2024105041', 'https://openalex.org/W2025013194', 'https://openalex.org/W2026107256', 'https://openalex.org/W2032563763', 'https://openalex.org/W2033774856', 'https://openalex.org/W2034759687', 'https://openalex.org/W2035523654', 'https://openalex.org/W2037875879', 'https://openalex.org/W2041620567', 'https://openalex.org/W2042409437', 'https://openalex.org/W2045429389', 'https://openalex.org/W2048380443', 'https://openalex.org/W2049137769', 'https://openalex.org/W2049856484', 'https://openalex.org/W2055057101', 'https://openalex.org/W2056801328', 'https://openalex.org/W2058115449', 'https://openalex.org/W2058570034', 'https://openalex.org/W2059421587', 'https://openalex.org/W2064580048', 'https://openalex.org/W2065392301', 'https://openalex.org/W2065638203', 'https://openalex.org/W2066745496', 'https://openalex.org/W2069990321', 'https://openalex.org/W2073942032', 'https://openalex.org/W2075482214', 'https://openalex.org/W2081808575', 'https://openalex.org/W2081936386', 'https://openalex.org/W2086495046', 'https://openalex.org/W2087877138', 'https://openalex.org/W2091006759', 'https://openalex.org/W2091459179', 'https://openalex.org/W2096417278', 'https://openalex.org/W2100327994', 'https://openalex.org/W2101681844', 'https://openalex.org/W2110621750', 'https://openalex.org/W2113839929', 'https://openalex.org/W2114060340', 'https://openalex.org/W2121208553', 'https://openalex.org/W2124785173', 'https://openalex.org/W2129589968', 'https://openalex.org/W2134919119', 'https://openalex.org/W2142877069', 'https://openalex.org/W2145156967', 'https://openalex.org/W2146226667', 'https://openalex.org/W2148283360', 'https://openalex.org/W2151384979', 'https://openalex.org/W2152084055', 'https://openalex.org/W2155523608', 'https://openalex.org/W2160330814', 'https://openalex.org/W2161032788', 'https://openalex.org/W2162653594', 'https://openalex.org/W2165437936', 'https://openalex.org/W2167031809', 'https://openalex.org/W2170785948', 'https://openalex.org/W2329506722', 'https://openalex.org/W2340163882', 'https://openalex.org/W3027785692', 'https://openalex.org/W4240465307', 'https://openalex.org/W4245093707', 'https://openalex.org/W4254357547', 'https://openalex.org/W4256031662'], 'related_works': ['https://openalex.org/W4381737908', 'https://openalex.org/W2968791743', 'https://openalex.org/W2377217489', 'https://openalex.org/W2373547774', 'https://openalex.org/W2281070672', 'https://openalex.org/W2135924782', 'https://openalex.org/W2062296662', 'https://openalex.org/W2011650496', 'https://openalex.org/W1951362600', 'https://openalex.org/W149533676'], 'abstract_inverted_index': {'Abstract': [0], 'Survivin': [1, 66, 87], 'is': [2, 37], 'an': [3, 84], 'inhibitor': [4], 'of': [5, 14, 31, 47, 76, 86], 'apoptosis': [6], 'protein': [7], '(IAP)': [8], 'expressed': [9], 'in': [10, 29, 39, 74, 98], 'a': [11, 52, 58], 'large': [12], 'number': [13], 'adult': [15, 41], 'malignancies.': [16, 81], 'Its': [17], 'expression': [18, 36, 67], 'levels': [19], 'correlate': [20], 'with': [21], 'more': [22, 78], 'aggressive': [23], 'disease': [24], 'and': [25, 56, 68, 89, 95], 'poor': [26], 'clinical': [27], 'outcome': [28], 'many': [30, 75], 'these': [32], 'tumors.': [33, 100], 'As': [34], 'its': [35, 93], 'restricted': [38], 'normal': [40], 'differentiated': [42], 'tissues,': [43], 'it': [44], 'has': [45], 'become': [46], 'great': [48], 'interest': [49], 'as': [50, 57], 'both': [51], 'tumor': [53], 'prognostic': [54], 'marker': [55], 'potential': [59], 'biologic': [60, 94], 'target': [61], 'for': [62], 'future': [63], 'anti‐cancer': [64], 'therapies.': [65], 'Survivin‐based': [69], 'therapies': [70], 'have': [71], 'been': [72], 'examined': [73], 'the': [77], 'common': [79], 'pediatric': [80, 99], 'We': [82], 'present': [83], 'overview': [85], 'function': [88], 'current': [90], 'research': [91], 'exploring': [92], 'therapeutic': [96], 'roles': [97], 'Pediatr': [101], 'Blood': [102], 'Cancer': [103], '©': [104], '2006': [105], 'Wiley‐Liss,': [106], 'Inc.': [107]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2062296662', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-09-09T15:58:25.087729', 'created_date': '2016-06-24'}