Loss of NF-κB Control and Repression of Prdx6 Gene Transcription by Reactive Oxygen Species-driven SMAD3-mediated Transforming Growth Factor β Signaling

Name: Work Video:
Duration: 3 min 30 s
Nigar Fatma; Eri Kubo; Yoshihiro Takamura; Keiichi Ishihara; Claudia M. Garcia; David C. Beebe; Dhirendra P. Singh
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'https://openalex.org/W2113967252', 'https://openalex.org/W2119365281', 'https://openalex.org/W2121124297', 'https://openalex.org/W2121126525', 'https://openalex.org/W2125655548', 'https://openalex.org/W2127298932', 'https://openalex.org/W2130608560', 'https://openalex.org/W2133485412', 'https://openalex.org/W2136160597', 'https://openalex.org/W2136451070', 'https://openalex.org/W2141960134', 'https://openalex.org/W2143118702', 'https://openalex.org/W2145589640', 'https://openalex.org/W2150073419', 'https://openalex.org/W2154568166', 'https://openalex.org/W2162937786', 'https://openalex.org/W2164066515', 'https://openalex.org/W2165445583', 'https://openalex.org/W2239066292', 'https://openalex.org/W2267571706', 'https://openalex.org/W4235438234'], 'related_works': ['https://openalex.org/W3018495632', 'https://openalex.org/W2914530652', 'https://openalex.org/W27859750', 'https://openalex.org/W2374261164', 'https://openalex.org/W2349610456', 'https://openalex.org/W2133584350', 'https://openalex.org/W1993987848', 'https://openalex.org/W1921622578', 'https://openalex.org/W1589838961', 'https://openalex.org/W1523254788'], 'abstract_inverted_index': {'Activation': [0, 1949], 'of': [1, 18, 22, 44, 70, 113, 120, 125, 130, 154, 171, 177, 181, 188, 192, 219, 890, 1071, 1138, 1271, 1276, 1300, 1304, 1306, 1312, 1320, 1378, 1383, 1393, 1410, 1419, 1427, 1436, 1441, 1539, 1551, 1559, 1586, 1596, 1950, 1962, 2071, 2101, 2168, 2189, 2208, 2220, 2280, 2350, 2358, 2381, 2472, 2475, 2497, 2513, 2516, 2704, 2708, 2732, 2768, 2925, 2934, 2955, 2969, 3050, 3072, 3077, 3094, 3104, 3136, 3152, 3156, 3187, 3203, 3277, 3284, 3349, 3373, 3378, 3392, 3427, 3498, 3523, 3537, 3615, 3621, 3680, 3693, 3698, 3778, 3894, 3931, 3952, 3955, 3964, 4018, 4022, 4049, 4291], 'transforming': [2, 1850], 'growth': [3, 415, 1851, 1871], 'factor': [4, 416, 1852, 2723], 'β': [5, 1853], '(TGFβ)': [6], 'in': [7, 30, 38, 73, 101, 109, 161, 179, 195, 208, 395, 658, 661, 1069, 1075, 1134, 1285, 1290, 1297, 1537, 1553, 1561, 1584, 1875, 1956, 2181, 2377, 2488, 2495, 2510, 2634, 2677, 2730, 2736, 2929, 2950, 2957, 3009, 3037, 3075, 3083, 3139, 3293, 3313, 3333, 3347, 3364, 3366, 3388, 3424, 3452, 3556, 3627, 3700, 3721, 3983, 4029, 4042, 4193, 4206], 'response': [8, 3140], 'to': [9, 16, 49, 79, 133, 146, 397, 421, 634, 638, 650, 894, 1274, 1294, 1400, 1407, 1417, 1603, 1862, 2206, 2217, 2299, 2352, 2764, 2918, 2952, 3034, 3092, 3141, 3192, 3196, 3251, 3255, 3306, 3318, 3344, 3395, 3660, 3689, 3869, 3914, 3939, 4027, 4167, 4171, 4178, 4182, 4186], 'increased': [10, 139, 168], 'reactive': [11, 399, 1839], 'oxygen': [12, 400, 408, 1840], 'species': [13, 401, 1841], '(ROS)': [14, 402], 'leads': [15], 'pathophysiology': [17, 1275, 2933], 'cells/tissues': [19], 'by': [20, 34, 128, 169, 430, 434, 1543, 1570, 2196, 2285, 2291, 2777, 2842, 2894, 3287, 3582, 3658, 3857, 3936, 4190, 4255], 'overmodulation': [21, 1305], 'gene': [23, 32, 1308, 2477, 2498, 3012, 3079, 3106, 3356, 3409, 4024], 'transcription.': [24, 1541, 2499], 'PRDX6': [25, 193, 213, 643, 891, 1065, 1272, 1571, 3816], 'plays': [26, 2506, 2726], 'a': [27, 186, 217, 427, 1295, 1298, 1381, 1535, 1548, 1575, 1580, 1869, 2098, 2187, 2507, 2630, 2670, 2687, 2694, 2714, 2719, 2885, 3275, 3304, 3341, 3376, 3383, 3428, 3695, 3784, 3878, 4114, 4263], 'rheostat': [28, 3384], 'role': [29, 176, 429, 1377, 1536, 2509, 2729, 3372, 3385], 'regulating': [31, 438], 'transcription': [33, 72, 156, 2306, 2515, 2722, 2887, 2924, 3107, 3259, 3357], 'controlling': [35], 'cellular': [36, 1421, 1877, 2769, 2793, 2958], 'ROS': [37, 51, 432, 436, 1291, 1379, 1552, 1567, 1582, 1597, 2177, 2956, 3374, 3398], 'maintaining': [39], 'homeostasis;': [40], 'thus,': [41], 'fine': [42, 1398], 'tuning': [43, 180, 1399, 3076], 'Prdx6': [45, 71, 86, 122, 140, 155, 182, 1394, 1429, 1442, 1540, 2170, 3011, 3038, 3052, 3078, 3105, 3137, 3158, 3285, 3335, 3355, 3393, 3966, 4023, 4044], 'expression': [46, 194, 889, 1269, 1309, 1395, 1435, 2357, 3080, 3286, 3394, 3890], 'is': [47, 77, 157, 216, 654, 1873, 2186, 2483, 2638, 2690, 2718, 2773, 2837, 2840, 2884, 2892, 3081, 3411], 'required': [48, 2639], 'optimize': [50], 'levels.': [52, 3399], 'Using': [53, 2165], 'Prdx6-': [54], 'and': [55, 66, 68, 94, 104, 135, 142, 148, 190, 201, 425, 433, 637, 667, 897, 1133, 1136, 1238, 1278, 1288, 1310, 1317, 1324, 1434, 1438, 1444, 1568, 1579, 1598, 1606, 1885, 1968, 2097, 2110, 2184, 2215, 2368, 2700, 2706, 2742, 2775, 2780, 2790, 2889, 2907, 2916, 2922, 2932, 2936, 2944, 2966, 2975, 3030, 3047, 3057, 3194, 3253, 3268, 3274, 3298, 3329, 3337, 3358, 3418, 3444, 3450, 3541, 3584, 3613, 3618, 3663, 3683, 3703, 3795, 3827, 3867, 3875, 3891, 3904, 3927, 3947, 3962, 3974, 3981, 3991, 4013, 4031, 4054, 4056, 4062, 4074, 4078, 4103, 4173, 4184, 4209, 4238, 4250, 4288], 'Smad3-depleted': [56], 'cells,': [57, 103, 2183, 2835, 3090], 'we': [58, 1388, 1431, 2172, 3068, 3280, 3299, 3381], 'show': [59], 'that': [60, 152, 224, 1268, 1390, 1530, 1590, 2176, 2204, 2276, 2504, 2629, 2689, 2734, 2964, 3161, 3315], 'Prdx6−/−': [61, 102, 134, 164, 2182, 3520, 4032, 4269], 'cells': [62, 75, 137, 165, 196, 1277, 1563, 1592, 2248, 2935, 3060, 3085, 3272, 3294, 3365, 3671, 4231], 'bear': [63, 1593], 'active': [64], 'NF-κB': [65, 95, 172, 178, 2772, 2836, 2883, 2911, 2970, 3004, 3073, 3189, 3387, 4051, 4073], 'Smad3,': [67, 3340, 3826], 'repression': [69, 119, 153, 189, 1538, 2496, 2707, 4017], 'redox-active': [74, 2715], '(Prdx6−/−)': [76, 3443], 'due': [78, 3091], 'ROS-induced': [80, 2942, 3309], 'dominant': [81], 'Smad3-mediated': [82, 3095, 3289], 'TGFβ': [83, 1316, 1437, 1560, 1951, 2072, 2190, 2192, 2200, 2351, 2490, 2505, 3350], 'signaling.': [84, 212, 3098], 'The': [85, 392, 631, 2348, 3099, 3400, 3610, 3653, 3910, 3987, 4034, 4108, 4121, 4197, 4246, 4257], 'promoter': [87, 99, 126, 2379, 2478, 2637, 2680, 3013, 3053, 3159, 3336, 3967, 4025], '(−1139': [88, 3913], 'bp)': [89, 3916], 'containing': [90], 'repressive': [91, 114, 1847, 2673, 3097, 4058], 'Smad3-binding': [92, 115, 413, 1848, 2674, 4059], 'elements': [93, 116, 2521, 3167, 3328, 3332, 4041, 4060], 'sites': [96, 2376, 3005, 3186, 3202, 4052, 4077], 'showed': [97], 'reduced': [98, 888], 'activity': [100, 106, 127, 160, 2223, 2891, 4105], 'the': [105, 118, 121, 175, 645, 662, 1321, 1376, 1403, 1408, 1412, 1428, 1557, 1963, 2169, 2199, 2218, 2245, 2277, 2287, 2356, 2378, 2469, 2476, 2486, 2511, 2514, 2635, 2641, 2678, 2683, 2709, 2791, 2914, 2919, 2953, 3010, 3051, 3070, 3153, 3157, 3188, 3258, 3263, 3282, 3308, 3334, 3367, 3371, 3408, 3425, 3496, 3530, 3538, 3557, 3619, 3678, 3691, 3715, 3801, 3859, 3895, 3898, 3945, 3965, 3984, 3994, 4038, 4043, 4124, 4147, 4154, 4194, 4251], 'was': [107, 166, 1564, 3686, 3902, 3921, 3934, 3989, 4101, 4106, 4143, 4248, 4253, 4260], 'restored': [108], 'Smad3−/−': [110, 136, 162, 3564, 3662, 3702, 4271], 'cells.': [111, 1555, 4033], 'Mutation': [112], 'eliminated': [117], 'promoter.': [123, 4045], 'Revival': [124], 'application': [129], 'TGFβ1': [131, 2114], 'antibody': [132, 1865, 3805, 3818, 3838, 3908], 'with': [138, 1545, 1566, 2198, 2294, 2304, 2896, 3055, 3458, 3797, 3845, 3861, 3877, 3906, 3968, 3977, 4071, 4081, 4090, 4235, 4284], 'mRNA': [141, 1443], 'protein': [143, 1445, 3342, 3779, 3853, 3896, 4100], 'conferred': [144], 'resistance': [145], 'TGFβ-': [147], 'H2O2-induced': [149], 'insult,': [150], 'demonstrating': [151], 'Smad3-dependent.': [158], 'Promoter': [159], 'or': [163, 199, 1385, 1573, 2251, 2301, 2354, 2844, 3088, 3143, 3415, 3430, 4095, 4164, 4169, 4175, 4180, 4270], 'moderately': [167], 'disruption': [170], 'sites,': [173], 'suggesting': [174, 1529], 'expression.': [183], 'Findings': [184], 'revealed': [185, 3160], 'mechanism': [187, 2471], 'regulation': [191, 1392, 2731, 3283, 3348, 3391], 'facing': [197, 3295], 'stress': [198, 1605, 2770, 3417], 'aging': [200, 1322, 3089, 3414], 'provided': [202], 'clues': [203, 3421], 'for': [204, 2640, 2702, 3386, 3714, 3993], 'antioxidant(s)-based': [205], 'new': [206], 'approaches': [207], 'preventing': [209], 'ROS-driven': [210, 3288], 'deleterious': [211], '(peroxiredoxin': [214], '6)': [215], 'member': [218], 'an': [220, 2212, 2727], 'emerging': [221], 'peroxiredoxin': [222], 'family': [223], 'has': [225, 1066, 1952, 2479, 2962, 3163], 'GSH': [226], 'peroxidase': [227], 'as': [228, 230, 1315, 1380, 1966, 2783, 3061, 3063, 3065, 3132, 3168, 3198, 3200, 3303, 3375, 3463, 3545, 3727, 3999, 4273, 4275, 4294], 'well': [229, 3064, 3199, 4274], 'acidic': [231], 'Ca2+-independent': [232], 'phospholipase': [233], 'A2': [234], 'activities': [235], '(1Fatma': [236, 442, 669, 1446, 1610, 3466, 3730, 4297], 'N.': [237, 258, 311, 338, 359, 443, 492, 519, 670, 691, 1109, 1333, 1447, 1470, 1497, 1611, 1632, 1685, 1712, 1911, 3467, 3731, 3754, 4298], 'Kubo': [238, 444, 671, 1448, 1612, 3468, 3732, 4299], 'E.': [239, 309, 334, 355, 445, 490, 515, 672, 1085, 1194, 1449, 1468, 1493, 1613, 1683, 1708, 1976, 3469, 3733, 3752, 4300], 'Sharma': [240, 446, 673, 1450, 1614, 3470, 3734, 4301], 'P.': [241, 447, 561, 674, 1111, 1451, 1615, 1769, 2003, 2819, 3471, 3735, 4302], 'Beier': [242, 314, 448, 495, 675, 1452, 1473, 1616, 1688, 3472, 3502, 3509, 3736, 3757, 4303], 'D.R.': [243, 315, 449, 496, 676, 1453, 1474, 1617, 1689, 3473, 3510, 3737, 3758, 4304], 'Singh': [244, 259, 316, 318, 341, 362, 450, 497, 499, 522, 677, 692, 1454, 1475, 1477, 1500, 1618, 1633, 1690, 1692, 1715, 3474, 3738, 3759, 3761, 4305], 'D.P.': [245, 260, 319, 342, 363, 451, 500, 523, 678, 693, 1455, 1478, 1501, 1619, 1634, 1693, 1716, 3475, 3739, 3762, 4306], 'Cell': [246, 323, 452, 504, 679, 821, 976, 1011, 1123, 1456, 1482, 1620, 1697, 1914, 2122, 3476, 3717, 3740, 3766, 4307], 'Death': [247, 453, 680, 1457, 1621, 3477, 3741, 4308], 'Differ.': [248, 454, 681, 1458, 1622, 3478, 3742, 4309], '2005;': [249, 384, 455, 682, 1459, 1623, 1736, 1984, 3479, 3743, 4310], '12:': [250, 456, 683, 1341, 1460, 1624, 1903, 3480, 3744, 4311], '734-750Crossref': [251, 457, 684, 1461, 1625, 3481, 3745, 4312], 'PubMed': [252, 277, 303, 328, 349, 371, 387, 458, 484, 509, 531, 551, 573, 605, 626, 685, 710, 742, 757, 793, 826, 867, 882, 927, 948, 981, 999, 1016, 1030, 1060, 1099, 1128, 1166, 1182, 1202, 1233, 1260, 1343, 1354, 1369, 1462, 1487, 1508, 1524, 1626, 1651, 1677, 1702, 1723, 1739, 1759, 1781, 1813, 1834, 1905, 1920, 1946, 1987, 2019, 2044, 2063, 2092, 2127, 2146, 2160, 2238, 2268, 2318, 2343, 2401, 2424, 2443, 2463, 2547, 2565, 2585, 2601, 2622, 2664, 2755, 2827, 2878, 2996, 3025, 3127, 3223, 3244, 3482, 3515, 3607, 3650, 3746, 3771], 'Scopus': [253, 278, 304, 329, 350, 372, 388, 459, 485, 510, 532, 552, 574, 606, 627, 686, 711, 743, 758, 794, 827, 868, 883, 928, 949, 982, 1000, 1017, 1031, 1061, 1100, 1129, 1167, 1183, 1203, 1234, 1261, 1344, 1355, 1370, 1463, 1488, 1509, 1525, 1627, 1652, 1678, 1703, 1724, 1740, 1760, 1782, 1814, 1835, 1906, 1921, 1988, 2020, 2045, 2064, 2093, 2128, 2147, 2161, 2239, 2269, 2319, 2344, 2402, 2444, 2464, 2548, 2566, 2602, 2623, 2665, 2756, 2828, 2879, 2997, 3026, 3128, 3224, 3245, 3483, 3516, 3747, 3772], '(75)': [254, 460, 687, 1464, 1628, 3484, 3748], 'Google': [255, 280, 306, 331, 352, 374, 390, 461, 487, 512, 534, 554, 576, 608, 629, 688, 713, 745, 760, 782, 796, 829, 839, 870, 885, 930, 951, 984, 1002, 1019, 1033, 1063, 1102, 1131, 1169, 1185, 1205, 1236, 1263, 1346, 1357, 1372, 1465, 1490, 1511, 1527, 1629, 1654, 1680, 1705, 1726, 1742, 1762, 1784, 1816, 1837, 1908, 1923, 1947, 1990, 2022, 2047, 2066, 2095, 2130, 2149, 2163, 2241, 2271, 2321, 2346, 2404, 2425, 2446, 2466, 2550, 2568, 2586, 2604, 2625, 2667, 2758, 2814, 2830, 2866, 2881, 2999, 3028, 3130, 3226, 3247, 3485, 3518, 3608, 3651, 3749, 3774], 'Scholar,': [256, 281, 307, 332, 353, 375, 462, 488, 513, 535, 555, 577, 609, 689, 714, 746, 761, 783, 797, 830, 840, 871, 931, 952, 985, 1003, 1020, 1034, 1103, 1186, 1347, 1358, 1466, 1491, 1512, 1630, 1655, 1681, 1706, 1727, 1743, 1763, 1785, 1817, 1909, 1924, 1991, 2023, 2048, 2131, 2150, 2322, 2405, 2426, 2447, 2551, 2569, 2587, 2815, 2867, 3227, 3750], '2Fatma': [257, 690, 1631], 'Shinohara': [261, 694, 1635], 'T.': [262, 336, 357, 517, 695, 813, 968, 994, 1083, 1337, 1495, 1636, 1710, 2981], 'Chylack': [263, 696, 1637], 'Jr.,': [264, 697, 1638], 'L.T.': [265, 698, 1639], 'J.': [266, 292, 321, 473, 502, 594, 699, 731, 777, 848, 916, 1010, 1089, 1122, 1153, 1198, 1250, 1338, 1480, 1640, 1666, 1695, 1802, 1942, 2009, 2039, 2079, 2085, 2121, 2140, 2233, 2258, 2391, 2452, 2536, 2576, 2593, 2595, 2751, 2796, 2823, 2848, 2873, 3213, 3603, 3646, 3764], 'Biol.': [267, 293, 382, 474, 568, 595, 700, 732, 822, 917, 977, 1124, 1519, 1641, 1667, 1734, 1776, 1803, 1900, 2420, 2439, 2453, 2537, 2577, 2660, 2809, 2861, 3020, 3122, 3240], 'Chem.': [268, 294, 475, 596, 701, 733, 918, 1363, 1642, 1668, 1804, 2454, 2538, 2578, 2810, 2862], '2001;': [269, 702, 1643, 1902, 2089], '276:': [270, 703, 1644], '48899-48907Abstract': [271, 704, 1645], 'Full': [272, 274, 298, 300, 479, 481, 600, 602, 705, 707, 737, 739, 922, 924, 1055, 1057, 1094, 1096, 1228, 1230, 1255, 1257, 1646, 1648, 1672, 1674, 1808, 1810, 2014, 2016, 2263, 2265, 2338, 2340, 2396, 2398, 2458, 2460, 2542, 2544, 2562, 2582, 2619, 3218, 3220], 'Text': [273, 275, 299, 301, 480, 482, 601, 603, 706, 708, 738, 740, 923, 925, 1056, 1058, 1095, 1097, 1229, 1231, 1256, 1258, 1647, 1649, 1673, 1675, 1809, 1811, 2015, 2017, 2264, 2266, 2339, 2341, 2397, 2399, 2459, 2461, 2543, 2545, 2563, 2583, 2620, 3219, 3221], 'PDF': [276, 302, 483, 604, 709, 741, 926, 1059, 1098, 1232, 1259, 1650, 1676, 1812, 2018, 2267, 2342, 2400, 2462, 2546, 2564, 2584, 2621, 3222], '(124)': [279, 712, 1653], '3Fisher': [282, 463, 1656], 'A.B.': [283, 379, 464, 619, 775, 803, 819, 941, 958, 974, 1657, 1731, 1827, 1938, 3117, 3599, 3642], 'Dodia': [284, 465, 764, 1658], 'C.': [285, 466, 587, 724, 765, 817, 909, 972, 987, 1040, 1081, 1113, 1213, 1659, 1795, 1940, 2083, 2328, 3601, 3644, 4096], 'Manevich': [286, 467, 614, 936, 1660, 1822], 'Y.': [287, 313, 340, 361, 377, 468, 494, 521, 611, 615, 933, 937, 1472, 1499, 1661, 1687, 1714, 1729, 1819, 1823, 1894, 2256, 2387, 2415, 2434, 2655, 3111, 3209, 3235, 3756], 'Chen': [288, 469, 766, 1662, 1931, 3592, 3635], 'J.W.': [289, 470, 1663, 1980, 2037, 2056], 'Feinstein': [290, 471, 612, 772, 934, 1664, 1820, 3118], 'S.I.': [291, 472, 613, 773, 935, 1665, 1821, 3119], '1999;': [295, 476, 823, 978, 1669, 1943, 2421, 2598, 3604, 3647], '274:': [296, 477, 780, 1670], '21326-21334Abstract': [297, 478, 1671], '(248)': [305, 486, 1679], '4Kubo': [308, 489, 1467, 1682, 3751], 'Fatma': [310, 337, 358, 491, 518, 1469, 1496, 1684, 1711, 3753], 'Akagi': [312, 339, 360, 493, 520, 1471, 1498, 1686, 1713, 3755], 'S.P.': [317, 498, 1476, 1691, 3760], 'Am.': [320, 501, 776, 1249, 1479, 1694, 3763], 'Physiol.': [322, 324, 503, 505, 778, 1481, 1483, 1696, 1698, 3765, 3767], '2008;': [325, 506, 1484, 1699, 3768], '294:': [326, 507, 1485, 1700, 3769], 'C842-C855Crossref': [327, 508, 1486, 1701, 3770], '(101)': [330, 511, 1489, 1704, 3773], '5Kubo': [333, 1492, 1707], 'Miyazawa': [335, 1494, 1709], 'Mech.': [343, 1502, 1717], 'Ageing': [344, 1503, 1718], 'Dev.': [345, 1026, 1504, 1719], '2006;': [346, 623, 945, 1091, 1163, 1505, 1720, 1831, 2011], '127:': [347, 1506, 1721], '249-256Crossref': [348, 1507, 1722], '(50)': [351, 1510, 1725], '6Kubo': [354, 514], 'Urakami': [356, 516], 'Biochem.': [364, 524, 547, 1197, 1755, 2874, 2991], 'Biophys.': [365, 525, 834], 'Res.': [366, 526, 863, 1162, 1364, 1916, 2087], 'Commun.': [367, 527], '2004;': [368, 528, 1052, 1225, 2440, 2661, 2993, 3241], '314:': [369, 529], '1050-1056Crossref': [370, 530], '(57)': [373, 533], '7Manevich': [376, 1728], 'Fisher': [378, 618, 774, 940, 1730, 1826, 3116], 'Free': [380, 566, 1517, 1732, 1774, 3018, 3120], 'Radic.': [381, 567, 1518, 1733, 1775, 3019, 3121], 'Med.': [383, 569, 1520, 1735, 1777, 3021, 3123], '38:': [385, 1737], '1422-1432Crossref': [386, 1738], '(331)': [389, 1741], 'Scholar).': [391, 630, 1064, 1264, 1373, 1838, 1948, 2067, 2164, 2272, 2347, 2467, 2605, 2759, 2831, 2882, 3000, 3486, 3519, 3609, 3652, 3775], 'peroxiredoxins': [393, 648], 'function': [394, 2735, 2946], 'concert': [396], 'detoxify': [398], '2The': [403], 'abbreviations': [404], 'used': [405, 3528, 3544, 3713, 3982, 3992, 4202], 'are:': [406], 'ROSreactive': [407], 'speciesLEClens': [409], 'epithelial': [410, 1843, 3271, 3434, 3670], 'cellSBESmad-binding': [411], 'elementRSBErepressive': [412], 'elementTGFβtransforming': [414], 'βTIETGFβ-inhibitory': [417], 'elementCATchloramphenicol': [418], 'acetyltransferaseELISAenzyme-linked': [419], 'immunoassayNACN-acetylcysteineMTS3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2': [420], '4-sulfophenyl)-2H-tetrazolium': [422, 1863], 'saltAbantibodyH2-DCF-DA2′,7′-dichlorodihydrofluorescein': [423], 'diacetate.': [424, 1867], 'play': [426], 'cytoprotective': [428], 'removing': [431], 'limiting': [435], 'levels': [437, 660, 1270, 1287, 1595, 2178, 2954], 'cell': [439, 895, 1608, 1844, 1880, 2738, 2740, 2902, 2973, 2976, 3435], 'survival': [440, 3362], 'signaling': [441, 636, 2195, 2253, 2284, 2491, 3074, 3292, 3312, 3363], '8Kim': [536, 1744], 'J.R.': [537, 1745], 'Yoon': [538, 1746], 'H.W.': [539, 1747], 'Kwon': [540, 1748], 'K.S.': [541, 1749], 'Lee': [542, 1750], 'S.R.': [543, 1751], 'Rhee': [544, 1752], 'S.G.': [545, 1753], 'Anal.': [546, 1754], '2000;': [548, 1756], '283:': [549, 1757], '214-221Crossref': [550, 1758], '(249)': [553, 1761], '9Phelan': [556, 1764], 'S.A.': [557, 581, 718, 787, 903, 1038, 1157, 1211, 1516, 1765, 1789, 3017], 'Wang': [558, 1766, 2416, 2435, 2656, 3236], 'X.': [559, 579, 716, 767, 801, 873, 901, 956, 1036, 1209, 1767, 1787, 1926, 2309, 3587, 3630], 'Wallbrandt': [560, 1768], 'Forsman-Semb': [562, 582, 719, 904, 1047, 1220, 1770, 1790], 'K.': [563, 583, 720, 905, 1048, 1221, 1331, 1771, 1791, 1913, 2077], 'Paigen': [564, 592, 729, 914, 1049, 1222, 1772, 1800], 'B.': [565, 593, 730, 750, 915, 1050, 1175, 1188, 1223, 1773, 1801, 2332, 2798, 2850], '2003;': [570, 597, 734, 790, 919, 1013, 1027, 1778, 1805, 1917, 2124, 2260, 2752], '35:': [571, 1779], '1110-1120Crossref': [572, 1780], '(48)': [575, 1783, 1922], '10Wang': [578, 715, 1786], 'Phelan': [580, 717, 786, 902, 1037, 1210, 1515, 1788, 3016], 'Taylor': [584, 721, 906, 1041, 1214, 1792], 'E.F.': [585, 722, 907, 1042, 1215, 1793], 'Petros': [586, 723, 908, 1039, 1212, 1794], 'Brown': [588, 725, 910, 1796], 'A.': [589, 726, 911, 1079, 1105, 1115, 1117, 1797, 1890, 1898, 1997, 2745, 3115], 'Lerner': [590, 727, 912, 1798], 'C.P.': [591, 728, 913, 1799], '278:': [598, 735, 920, 1806], '25179-25190Abstract': [599, 736, 921, 1807], '(275)': [607, 744, 929, 1815], '11Wang': [610, 932, 1818], 'Ho': [616, 938, 1824], 'Y.S.': [617, 939, 1825], 'Antioxid.': [620, 942, 1828], 'Redox.': [621, 788, 943, 1829], 'Signal.': [622, 944, 1830], '8:': [624, 791, 946, 1832], '229-237Crossref': [625, 947, 1833], '(86)': [628, 950, 1836, 2465], 'unique': [632], 'ability': [633, 2349], 'regulate': [635, 3361], 'maintain': [639, 3396], 'phospholipid': [640], 'turnover': [641], 'distinguishes': [642], 'from': [644, 2693, 3257, 3437, 3440, 3569, 3674, 3677, 3809, 3923, 4128], 'other': [646], 'five': [647], '(PRDX1': [649], '-5).': [651], 'This': [652, 2938], 'molecule': [653, 1532, 2939], 'widely': [655], 'expressed,': [656], 'occurring': [657], 'high': [659], 'liver,': [663], 'lung,': [664], 'eye': [665], 'lens,': [666], 'keratinocytes': [668], '12Frank': [747], 'S.': [748, 752, 1087, 1121, 1173, 1177, 1190, 1196, 1335, 1892, 2324, 2802, 2806, 2854, 2858, 2983], 'Munz': [749, 1174], 'Werner': [751, 1086, 1120, 1176, 1195], 'Oncogene.': [753, 1178], '1997;': [754, 1179, 1199, 1366, 2455, 2811, 2863, 3512], '14:': [755, 1180], '915-921Crossref': [756, 1181], '(109)': [759, 1184], '13Kim': [762], 'T.S.': [763], 'Hennigan': [768], 'B.B.': [769], 'Jain': [770], 'M.': [771, 805, 811, 877, 960, 966, 1107, 1150, 1329, 2081, 2313, 2990], '1998;': [779, 2335], 'L750-L761PubMed': [781], '14Sparling': [784], 'N.E.': [785, 2573], 'Rep.': [789], '87-94Crossref': [792], '(19)': [795], '15Ashcroft': [798, 953], 'G.S.': [799, 954], 'Yang': [800, 955], 'Glick': [802, 957], 'Weinstein': [804, 959], 'Letterio': [806, 961, 1927, 3588, 3631], 'J.L.': [807, 962, 2225], 'Mizel': [808, 963], 'D.E.': [809, 964], 'Anzano': [810, 965], 'Greenwell-Wild': [812, 967], 'Wahl': [814, 969], 'S.M.': [815, 970], 'Deng': [816, 971, 1939, 3583, 3600, 3643], 'Roberts': [818, 973, 1937, 3598, 3641], 'Nat.': [820, 975], '1:': [824, 979], '260-266Crossref': [825, 980], '(782)': [828, 983], '16Baeuerle': [831], 'P.A.': [832, 2033, 2821, 2871], 'Biochim.': [833], 'Acta.': [835], '1991;': [836, 2824], '1072:': [837], '63-80PubMed': [838], '17Chang': [841], 'X.Z.': [842], 'Li': [843], 'D.Q.': [844], 'Hou': [845], 'Y.F.': [846], 'Wu': [847], 'Lu': [849], 'J.S.': [850, 1007, 2118], 'Di': [851], 'G.H.': [852], 'Jin': [853], 'W.': [854, 1119], 'Ou': [855], 'Z.L.': [856], 'Shen': [857], 'Z.Z.': [858], 'Shao': [859], 'Z.M.': [860], 'Breast': [861], 'Cancer': [862], '2007;': [864, 1125, 1521, 3022], '9:': [865], 'R76Crossref': [866], '(148)': [869], '18Chen': [872], 'Rubock': [874, 2310], 'M.J.': [875, 2311], 'Whitman': [876, 2312], 'Nature.': [878, 2234, 2314], '1996;': [879, 2157, 2315], '383:': [880, 2316], '691-696Crossref': [881, 2317], '(635)': [884, 2320], 'Scholar),': [886, 1170, 1237, 1528, 2096, 2242], 'whereas': [887], 'can': [892, 2112], 'lead': [893, 3317], 'death': [896, 1609], 'tissue': [898], 'degeneration': [899], '(10Wang': [900], '19Abate': [986], 'Patel': [988], 'L.': [989, 1932, 2227, 2326, 2411, 2527, 3113, 3593, 3636], 'Rauscher': [990], '3rd,': [991], 'F.J.': [992, 1978, 2025, 2052], 'Curran': [993], 'Science.': [995, 1350], '1990;': [996, 2559, 2616], '249:': [997], '1157-1161Crossref': [998], '(1383)': [1001], '20Annes': [1004], 'J.P.': [1005, 2116, 2409, 2428, 2649, 3229], 'Munger': [1006, 2117], 'Rifkin': [1008, 2119], 'D.B.': [1009, 2120, 2555, 2612], 'Sci.': [1012, 2123], '116:': [1014, 2125], '217-224Crossref': [1015, 2126], '(1359)': [1018, 2129], '21An': [1021], 'J.H.': [1022, 1145, 1242], 'Blackwell': [1023], 'T.K.': [1024], 'Genes': [1025], '17:': [1028], '1882-1893Crossref': [1029], '(552)': [1032], '22Wang': [1035], 'Ledinski': [1043, 1216], 'G.': [1044, 1046, 1192, 1217, 1219, 1995, 2449, 2800, 2852, 2986], 'Jürgens': [1045, 1218], 'Atherosclerosis.': [1051, 1224], '177:': [1053, 1226], '61-70Abstract': [1054, 1227], '(61)': [1062, 1235, 1262], 'been': [1067, 1954, 2480, 3007, 3032, 3580, 3625], 'implicated': [1068, 1955], 'maintenance': [1070, 1418], 'blood': [1072], 'vessel': [1073], 'integrity': [1074], 'wounded': [1076], 'skin': [1077], '(23Kümin': [1078], 'Huber': [1080], 'Rülicke': [1082], 'Wolf': [1084], 'Am': [1088, 2008], 'Pathol.': [1090, 1251, 2010], '169:': [1092], '1194-1205Abstract': [1093], '(97)': [1101], '24Kümin': [1104], 'Schäfer': [1106], 'Epp': [1108], 'Bugnon': [1110], 'Born-Berclaz': [1112], 'Oxenius': [1114], 'Klippel': [1116], 'Bloch': [1118], '179:': [1126, 1985], '747-760Crossref': [1127], '(76)': [1130], 'Scholar)': [1132, 1206, 2626, 2668, 3029, 3131, 3248], 'development': [1135, 3426], 'progression': [1137], 'several': [1139, 2069, 2359], 'diseases,': [1140, 1959], 'including': [1141, 1879, 1960, 2103, 2361, 3184, 3321], 'oxidative-induced': [1142], 'cataractogenesis': [1143], '(25Pak': [1144], 'Kim': [1146, 1149, 1152, 1156], 'T.I.': [1147], 'Joon': [1148], 'Yong': [1151], 'Choi': [1154], 'H.J.': [1155], 'Tchah': [1158], 'H.': [1159, 1936, 3508, 3597, 3640], 'Exp.': [1160, 2058], 'Eye': [1161], '82:': [1164], '899-906Crossref': [1165], '(32)': [1168], 'psoriasis': [1171], '(12Frank': [1172], '26Munz': [1187], 'Frank': [1189], 'Hübner': [1191], 'Olsen': [1193], '326:': [1200], '579-585Crossref': [1201], '(106)': [1204], 'atherosclerosis': [1207], '(22Wang': [1208], 'Parkinsonian': [1239], 'dementia': [1240], '(27Power': [1241], 'Shannon': [1243], 'J.M.': [1244], 'Blumbergs': [1245], 'P.C.': [1246], 'Gai': [1247], 'W.P.': [1248], '2002;': [1252, 2041, 2060, 2393, 2539, 3215], '161:': [1253], '885-894Abstract': [1254], 'Accumulating': [1265], 'evidence': [1266, 2274], 'indicates': [1267], 'contribute': [1273], 'tissues.': [1279, 2937], 'Several': [1280], 'studies': [1281, 2501, 3401], 'have': [1282, 1534, 2173, 2502, 2627, 3006, 3031, 3300, 3579, 3624], 'reported': [1283, 1432, 3402, 4295], 'decreases': [1284], 'antioxidant': [1286], 'increases': [1289], 'levels,': [1292], 'leading': [1293, 2216], 'decline': [1296], 'number': [1299], 'physiological': [1301, 3397], 'functions': [1302], 'because': [1303], 'ROS-mediated': [1307], 'activation': [1311, 1433, 1558, 2073, 2219, 2279, 2474, 2725, 3093, 3103], 'such': [1313, 1965, 2782], 'factors': [1314, 2307, 2761], 'NF-κB,': [1318, 2713], 'hallmarks': [1319], 'process': [1323, 3100], 'age-associated': [1325], 'degenerative': [1326, 3319], 'diseases': [1327], '(28Higuchi': [1328], 'Shirotani': [1330], 'Higashi': [1332], 'Toyoshima': [1334], 'Osawa': [1336], 'Immunother.': [1339], '1992;': [1340, 1351], '41-49Crossref': [1342], '(18)': [1345], '29Stadtman': [1348], 'E.R.': [1349, 1360], '257:': [1352], '1220-1224Crossref': [1353], '(2417)': [1356], '30Stadtman': [1359], 'Berlett': [1361], 'B.S.': [1362], 'Toxicol.': [1365], '10:': [1367, 2158, 2825], '485-494Crossref': [1368], '(617)': [1371], 'However,': [1374, 3040, 3146], 'given': [1375], 'mediator': [1382, 3377], 'normal': [1384, 1420, 3379], 'redox': [1386, 1414, 3368], 'signaling,': [1387, 3380], 'believe': [1389], 'optimal': [1391], 'may': [1396, 1533, 2940, 2947, 3316, 3353], 'require': [1397], 'avoid': [1401], 'overshooting': [1402], 'desired': [1404], 'beneficial': [1405], 'effects': [1406], 'point': [1409, 4191], 'perturbing': [1411], 'delicate': [1413], 'balance': [1415], 'essential': [1416], 'function.': [1422], 'Recently,': [1423, 2644, 3001], 'using': [1424, 3045, 3266, 3944, 4113, 4146, 4262, 4282], 'targeted': [1425, 2166], 'inactivation': [1426, 2167], 'gene,': [1430, 2171], 'TGFβ-mediated': [1439, 2278], 'suppression': [1440], '31Gallagher': [1513], 'B.M.': [1514, 3015], '42:': [1522, 3023, 3513], '1270-1277Crossref': [1523, 3024], '(51)': [1526, 3027], 'this': [1531, 2185, 3302], 'Quantification': [1542], 'staining': [1544], 'H2DCF-DA': [1546], 'established': [1547], 'higher': [1549, 1594], 'prevalence': [1550], 'these': [1554, 2382], 'Also,': [1556], 'Prdx6-deficient': [1562, 3058], 'associated': [1565], 'inhibited': [1569], 'overexpression': [1572], 'MnTBAP,': [1574], 'superoxide': [1576], 'dismutase': [1577], 'mimetic': [1578], 'known': [1581, 2075, 2484, 3343], 'inhibitor,': [1583], 'view': [1585], 'our': [1587], 'earlier': [1588, 3465, 3901, 4296], 'finding(s)': [1589], 'Prdx6-depleted': [1591, 3084], 'are': [1599, 2074, 2179, 2762, 4205], 'thereby': [1600, 3359], 'more': [1601], 'susceptible': [1602], 'oxidative': [1604, 2785, 3296, 3416], 'apoptotic': [1607], 'lens': [1842, 3059, 3270, 3669], 'Smad-binding': [1845, 2696], 'element': [1846, 1849, 1855, 2633, 2675, 2697], 'TGFβ-inhibitory': [1854, 2520], 'chloramphenicol': [1856], 'acetyltransferase': [1857], 'enzyme-linked': [1858], 'immunoassay': [1859], 'N-acetylcysteine': [1860], '3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2': [1861], 'salt': [1864], '2′,7′-dichlorodihydrofluorescein': [1866], 'TGFβ,': [1868], 'multipotent': [1870], 'factor,': [1872, 2888], 'involved': [1874, 2928, 3036, 3346], 'various': [1876, 2517, 3164], 'processes,': [1878], 'proliferation,': [1881, 2739], 'differentiation,': [1882], 'apoptosis,': [1883], 'migration,': [1884], 'extracellular': [1886], 'matrix': [1887], 'formation': [1888], '(32Kurisaki': [1889], 'Kose': [1891], 'Yoneda': [1893], 'Heldin': [1895], 'C.H.': [1896], 'Moustakas': [1897], 'Mol.': [1899, 2155, 2333, 2418, 2437, 2658, 3238], 'Cell.': [1901, 2259, 2334, 2392, 2419, 2438, 2558, 2615, 2659, 3214, 3239], '1079-1091Crossref': [1904], '(155)': [1907], '33Dünker': [1910], 'Krieglstein': [1912], 'Tissue': [1915], '313:': [1918], '1-10Crossref': [1919], '34Yang': [1925], 'J.J.': [1928, 3589, 3632], 'Lechleider': [1929, 3590, 3633], 'R.J.': [1930, 2533, 3591, 3634], 'Hayman': [1933, 3594, 3637], 'R.': [1934, 2135, 2229, 2817, 3501, 3595, 3638], 'Gu': [1935, 3596, 3639], 'EMBO': [1941, 2750, 2822, 3602, 3645], '18:': [1944, 3605, 3648], '1280-1291Crossref': [1945, 3606, 3649], 'also': [1953, 2174], 'multiple': [1957], 'fibrotic': [1958], 'those': [1961], 'eye,': [1964], 'glaucoma': [1967], 'anterior': [1969], 'subcapsular': [1970], 'cataract': [1971], '(35de': [1972], 'Iongh': [1973], 'R.U.': [1974], 'Wederell': [1975], 'Lovicu': [1977, 2051], 'McAvoy': [1979, 2036, 2055], 'Cells': [1981, 4086], 'Tissues': [1982], 'Organs.': [1983], '43-55Crossref': [1986], '(260)': [1989], '36Dwivedi': [1992], 'D.J.': [1993], 'Pino': [1994], 'Banh': [1996], 'Nathu': [1998], 'Z.': [1999], 'Howchin': [2000], 'D.': [2001, 2749, 2979], 'Margetts': [2002], 'Sivak': [2004], 'J.G.': [2005], 'West-Mays': [2006], 'J.A.': [2007, 2139], '168:': [2012], '69-79Abstract': [2013], '(73)': [2021], '37Lovicu': [2024], 'Schulz': [2026], 'M.W.': [2027], 'Hales': [2028], 'A.M.': [2029], 'Vincent': [2030], 'L.N.': [2031], 'Overbeek': [2032], 'Chamberlain': [2034, 2053], 'C.G.': [2035, 2054], 'Br.': [2038], 'Ophthalmol.': [2040], '86:': [2042], '220-226Crossref': [2043], '(141)': [2046], '38Maruno': [2049], 'K.A.': [2050], 'Clin.': [2057, 2141], 'Optom.': [2059], '85:': [2061], '76-82Crossref': [2062], '(56)': [2065], 'Moreover,': [2068, 2712], 'mechanisms': [2070], '(39Koli': [2076], 'Saharinen': [2078], 'Hyytiäinen': [2080], 'Penttinen': [2082], 'Keski-Oja': [2084], 'Microsc.': [2086], 'Tech.': [2088], '52:': [2090], '354-362Crossref': [2091], '(227)': [2094], 'diverse': [2099], 'group': [2100], 'activators,': [2102], 'trauma,': [2104], 'proteases,': [2105], 'TSP-1,': [2106], 'integrin,': [2107], 'low': [2108], 'pH,': [2109], 'ROS,': [2111], 'activate': [2113], '(20Annes': [2115], '40Barcellos-Hoff': [2132], 'M.H.': [2133, 2152], 'Derynck': [2134], 'Tsang': [2136], 'M.L.': [2137], 'Weatherbee': [2138], 'Invest.': [2142], '1994;': [2143, 2235], '93:': [2144], '892-899Crossref': [2145], '(375)': [2148], '41Barcellos-Hoff': [2151], 'Dix': [2153], 'T.A.': [2154], 'Endocrinol.': [2156], '1077-1083Crossref': [2159], '(489)': [2162], 'shown': [2175, 2628, 2963, 3301], 'elevated': [2180], 'cause': [2188], 'activation.': [2191], 'initiates': [2193, 2923], 'its': [2194, 2493, 2890, 2945], 'interaction': [2197, 2303, 2895], 'type': [2201, 2209, 2369, 2974, 4208], 'II': [2202], 'receptor': [2203], 'proceeds': [2205], 'phosphorylation': [2207], 'I,': [2210], 'forming': [2211], 'activated': [2213, 2776], 'complex': [2214], 'TGFβRI': [2221], 'kinase': [2222], '(42Wrana': [2224], 'Attisano': [2226], 'Wieser': [2228], 'Ventura': [2230], 'F.': [2231], 'Massagué': [2232, 2257, 2390, 3212], '370:': [2236], '341-347Crossref': [2237], '(2140)': [2240], 'which': [2243, 2489], 'transmits': [2244], 'signal': [2246], 'into': [2247, 2913], 'through': [2249], 'Smads-mediated': [2250], 'alternative': [2252], 'pathways': [2254], '(43Shi': [2255], '113:': [2261], '685-700Abstract': [2262], '(4939)': [2270], 'Growing': [2273], 'suggests': [2275], 'Smads': [2281], 'regulates': [2282], 'downstream': [2283], 'modulating': [2286], 'transcriptional': [2288, 2295, 2716], 'activity,': [2289], 'either': [2290], 'functional': [2292], 'cooperation': [2293], 'proteins,': [2296, 2899], 'direct': [2297, 2302], 'binding': [2298, 2703], 'DNA,': [2300], 'DNA-bound': [2305], '(18Chen': [2308], '44Zhou': [2323], 'Zawel': [2325], 'Lengauer': [2327], 'Kinzler': [2329], 'K.W.': [2330], 'Vogelstein': [2331], '2:': [2336], '121-127Abstract': [2337], '(213)': [2345], 'induce': [2353], 'suppress': [2355], 'genes,': [2360, 3352], 'PAI-1,': [2362], 'clusterin,': [2363], 'monocyte': [2364], 'chemoattractant': [2365], 'protein-1': [2366], '(JE/MCP-1),': [2367], 'I': [2370], 'collagen,': [2371], 'depends': [2372], 'on': [2373, 2972, 3042, 4242], 'specific': [2374, 2897, 3553, 3696], 'DNA-binding': [2375], 'regions': [2380], 'genes': [2383, 2518, 2733], '(45Chen': [2384, 3206], 'C.R.': [2385, 3207], 'Kang': [2386, 3208], 'Siegel': [2388, 3210], 'P.M.': [2389, 3211], '110:': [2394, 3216], '19-32Abstract': [2395, 3217], '(397)': [2403, 3225], '46Datto': [2406], 'M.B.': [2407], 'Frederick': [2408, 2645], 'Pan': [2410], 'Borton': [2412], 'A.J.': [2413], 'Zhuang': [2414], 'X.F.': [2417, 2436, 2657, 3237], '19:': [2422], '2495-2504Crossref': [2423], '47Frederick': [2427, 3228], 'Liberati': [2429, 2650, 3230], 'N.T.': [2430, 2651, 3231], 'Waddell': [2431, 2652, 3232], 'D.S.': [2432, 2653, 3233], 'Shi': [2433, 2654, 3234], '24:': [2441, 2662, 3242], '2546-2559Crossref': [2442, 2663, 3243], '(190)': [2445, 2666, 3246], '48Jin': [2448], 'Howe': [2450], 'P.H.': [2451], '272:': [2456], '26620-26626Abstract': [2457], 'Although': [2468], 'molecular': [2470], 'TGFβ-induced': [2473, 3096], 'established,': [2481], 'less': [2482], 'about': [2485], 'way': [2487], 'exerts': [2492], 'effect': [2494], 'Earlier': [2500, 2960], 'documented': [2503], 'regulatory': [2508, 3166], 'modulation': [2512], 'via': [2519], '(TIEs;': [2522], 'nnnTTGGnnn)': [2523], '(49Hirschi': [2524], 'K.K.': [2525], 'Lai': [2526], 'Belaguli': [2528], 'N.S.': [2529], 'Dean': [2530], 'D.A.': [2531], 'Schwartz': [2532], 'Zimmer': [2534], 'W.E.': [2535], '277:': [2540], '6287-6295Abstract': [2541], '(79)': [2549], '50Kerr': [2552], 'L.D.': [2553, 2571, 2610], 'Miller': [2554, 2611], 'Matrisian': [2556, 2574, 2613], 'L.M.': [2557, 2575, 2614], '61:': [2560, 2617], '267-278Abstract': [2561, 2618], '(386)': [2567, 2624], '51Kerr': [2570], 'Olashaw': [2572], '1988;': [2579], '263:': [2580], '16999-17005Abstract': [2581], '52Mostert': [2588], 'V.': [2589, 2808, 2860], 'Dreher': [2590], 'I.': [2591, 3109], 'Kohrle': [2592], 'Abel': [2594], 'FEBS': [2596], 'Lett.': [2597], '460:': [2599], '23-26Crossref': [2600], '(29)': [2603], 'Kerr': [2606], 'et': [2607, 2646], 'al.': [2608, 2647], '(50Kerr': [2609], '10-base': [2631], 'pair': [2632], 'transin': [2636], 'TGFβ1-inhibitory': [2642], 'effects.': [2643], '(47Frederick': [2648], 'discovered': [2669], 'potential': [2671], 'consensus': [2672, 2695], '(RSBE)': [2676], 'c-myc': [2679, 2684, 2710], 'sequence': [2681], 'overlapping': [2682], 'TIE': [2685], '(5′-TTGGCGGGAA-3′),': [2686], 'site': [2688, 4084], 'notably': [2691], 'different': [2692, 2778, 3956, 4019], '(SBE;': [2698], '5′-GTCT-3′)': [2699], 'responsible': [2701], 'Smad3': [2705], 'gene.': [2711], 'protein,': [2717], 'ubiquitous,': [2720], 'multisubunit': [2721, 2886], 'whose': [2724], 'important': [2728], 'inflammation,': [2737], 'survival,': [2741], 'apoptosis': [2743], '(53Hoffmann': [2744], 'Leung': [2746], 'T.H.': [2747], 'Baltimore': [2748], '22:': [2753], '5530-5539Crossref': [2754], '(294)': [2757], 'Such': [2760], 'considered': [2763], 'be': [2765, 2948, 3035, 3345], 'key': [2766], 'regulators': [2767], 'response.': [2771], 'induced': [2774, 2841], 'stimuli': [2779], 'conditions,': [2781], 'pathology,': [2784], 'stress,': [2786, 2943, 3297], 'hypoxia,': [2787], 'inflammatory': [2788, 2930], 'mediators,': [2789], 'internal': [2792, 2843, 3142], 'microenvironment': [2794], '(54Piette': [2795, 2847], 'Piret': [2797, 2849], 'Bonizzi': [2799, 2851], 'Schoonbroodt': [2801, 2853], 'Merville': [2803, 2855], 'M.P.': [2804, 2856], 'Legrand-Poels': [2805, 2857], 'Bours': [2807, 2859], '378:': [2812, 2864], '1237-1245PubMed': [2813, 2865], '55Schreck': [2816], 'Rieber': [2818], 'Baeuerle': [2820, 2870], '2247-2258Crossref': [2826], '(3476)': [2829], 'In': [2832, 3262], 'unstimulated': [2833], 'resting': [2834], 'inactive;': [2838], 'it': [2839, 3162, 3938], 'external': [2845, 3144], 'stresses': [2846], '56Rupec': [2868], 'R.A.': [2869], 'Eur.': [2872], '1995;': [2875], '234:': [2876], '632-640Crossref': [2877], '(161)': [2880], 'regulated': [2893], 'inhibitory': [2898], 'Iκ-Bs.': [2900], 'Upon': [2901], 'stimulation,': [2903], 'IκBs': [2904], 'become': [2905], 'phosphorylated': [2906], 'subsequently': [2908], 'ubiquitinylated.': [2909], 'Released': [2910], 'translocates': [2912], 'nucleus': [2915], 'binds': [2917], 'target': [2920, 3351], 'sequences': [2921], '"defense': [2926], 'genes"': [2927], 'responses': [2931], 'sense': [2941, 3970], 'altered': [2949], 'relation': [2951], 'microenvironment.': [2959], 'study': [2961, 3044, 3307], 'proapoptotic': [2965], 'antiapoptotic': [2967], 'roles': [2968], 'depend': [2971], 'environment': [2977], '(57Uberti': [2978], 'Carsana': [2980], 'Francisconi': [2982], 'Ferrari': [2984], 'Toninelli': [2985], 'Canonico': [2987], 'P.L.': [2988], 'Memo': [2989], 'Pharmacol.': [2992], '67:': [2994], '1743-1750Crossref': [2995], '(27)': [2998], 'two': [3002, 3185, 3201, 3325, 3330, 4050, 4057, 4075], 'putative': [3003, 3165, 4039], 'predicted': [3008], '(31Gallagher': [3014], 'thought': [3033], 'regulation.': [3039], 'based': [3041], 'current': [3043], 'transactivation': [3046], 'mutational': [3048], 'analysis': [3049, 3149, 3685], 'coupled': [3054], 'Smad3-': [3056], 'models': [3062], 'biochemical': [3066, 3278], 'assays,': [3067, 3279], 'think': [3069], 'control': [3071, 3546], 'attenuated': [3082], '(redox': [3086], 'state)': [3087], 'attenuates': [3101], 'Nrf2': [3102], '(58Chowdhury': [3108], 'Mo': [3110], 'Gao': [3112], 'Kazi': [3114], '2009;': [3124], '46:': [3125], '146-153Crossref': [3126], '(121)': [3129], 'well.': [3133], 'Thus,': [3134], 'autoregulation': [3135], 'disrupted': [3138], 'stressors.': [3145], 'Web-based': [3147], 'computer': [3148], '(MatInspector;': [3150], 'Genomatix)': [3151], '5′-flanking': [3154, 3911], 'region': [3155, 3912], 'follows:': [3169, 4000], 'SP1,': [3170], 'E2F-Myc,': [3171], 'Nrf2,': [3172], 'HIF1α,': [3173], 'PBX1-MEIS1,': [3174], 'EREs,': [3175], 'GRE,': [3176], 'GATA-1,': [3177], 'HSF1,': [3178], 'LEDGF,': [3179], 'c-ETS-1,': [3180], 'v-Myb,': [3181], 'Oct1/Oct2,': [3182], 'etc.,': [3183], 'at': [3190, 3249, 3491, 3560, 3800], '−644': [3191], '−635': [3193], '−948': [3195], '−939': [3197], 'RSBE': [3204, 3331, 4076, 4083], '(TIE)': [3205], '−379': [3250], '−367': [3252], '−482': [3254], '−471': [3256], 'start': [3260], 'site.': [3261], 'present': [3264, 3531, 3985], 'investigation,': [3265], 'Prdx6−/−-': [3267], 'Smad3−/−-deficient': [3269], '(LECs)': [3273], 'variety': [3276], 'examined': [3281], 'TGFβ1-induced': [3290], 'adverse': [3291, 3311], 'model': [3305], 'TGFβ1-mediated': [3310], 'LECs': [3314, 3705, 3709, 4272, 4279], 'disorders,': [3320], 'cataractogenesis.': [3322], 'We': [3323], 'identified': [3324], 'novel': [3326], 'NF-κB-binding': [3327], 'demonstrated': [3338], 'how': [3339, 3407], 'attenuate': [3354], 'negatively': [3360], 'state.': [3369], 'Given': [3370], 'propose': [3382], 'determining': [3389], 'optimum': [3390], 'here': [3403], 'provide': [3404, 3420], 'insight': [3405], 'regarding': [3406], 'network': [3410], 'changed': [3412], 'during': [3413, 3529], 'should': [3419], 'potentially': [3422], 'useful': [3423], 'transcription-': [3429], 'antioxidant-based': [3431], 'therapy.': [3432], 'Lens': [3433], 'lines': [3436], 'lenses': [3438, 3675], 'isolated': [3439, 3673, 3676, 3922], 'Prdx6-targeted': [3441], 'mutants': [3442, 3954, 4021, 4066], 'wild-type': [3445, 3664, 4278], '(Prdx6+/+)': [3446], 'mice': [3447, 3488, 3522, 3536, 3566, 3578, 3617, 3623, 3679], 'were': [3448, 3489, 3527, 3543, 3550, 3567, 3656, 3672, 3712, 3719, 3781, 3843, 3855, 3979, 3998, 4067, 4087, 4111, 4188, 4201, 4233, 4240, 4280], 'generated': [3449, 3490, 3581, 4189], 'maintained': [3451, 3551], "Dulbecco's": [3453], 'modified': [3454], "Eagle's": [3455], 'medium': [3456], '(DMEM)': [3457], '10%': [3459, 3785], 'fetal': [3460], 'bovine': [3461], 'serum': [3462], 'described': [3464, 3626, 3728], 'Prdx6−/−129/Sv': [3487], 'Harvard': [3492, 3561, 3813], 'Medical': [3493, 3562, 3814, 3884], 'School': [3494], 'under': [3495, 3552], 'supervision': [3497], 'Dr.': [3499, 3570, 3810], 'David': [3500], '(59Iakoubova': [3503], 'O.A.': [3504], 'Pacella': [3505], 'L.A.': [3506], 'Her': [3507], 'Genomics.': [3511], '474-478Crossref': [3514], '(45)': [3517], 'mutant': [3521, 3616], 'pure': [3524], '129': [3525], 'background': [3526], 'study.': [3532, 3986], 'Wild-type': [3533], '129/Sv': [3534], 'inbred': [3535], 'same': [3539], 'sex': [3540], 'age': [3542], '(Prdx6+/+).': [3547], 'All': [3548], 'animals': [3549], 'pathogen-free': [3554], 'conditions': [3555], 'animal': [3558], 'house': [3559], 'School.': [3563], 'knock-out': [3565], 'obtained': [3568], 'Beebe': [3571], '(Washington': [3572], 'University,': [3573], 'St.': [3574], 'Louis,': [3575], 'MO).': [3576], 'These': [3577], 'co-workers': [3585], '(34Yang': [3586, 3629], 'generation,': [3611], 'characterization,': [3612], 'mating': [3614], 'progeny': [3620, 3655], 'Smad3-targeted': [3622], 'detail': [3628], 'resulting': [3654], 'screened': [3657], 'PCR': [3659], 'identify': [3661], 'mice.': [3665], 'As': [3666], 'mentioned': [3667], 'above,': [3668], 'identical': [3681], 'age,': [3682], 'Western': [3684], 'carried': [3687, 4144], 'out': [3688, 4145], 'confirm': [3690], 'presence': [3692], 'αA-crystallin,': [3694], 'marker': [3697], 'LECs,': [3699], 'both': [3701], 'Smad3+/+': [3704], '(see': [3706], 'Fig.': [3707], '9B).': [3708], '(passages': [3710], '3–5)': [3711], 'experiments.': [3716], 'lysates': [3718], 'prepared': [3720, 3935], 'ice-cold': [3722], 'radioimmunoprecipitation': [3723], 'assay': [3724, 4259], 'lysis': [3725], 'buffer,': [3726], 'previously': [3729], 'Equal': [3776], 'amounts': [3777], 'samples': [3780], 'loaded': [3782], 'onto': [3783, 3788], 'SDS-gel,': [3786], 'blotted': [3787], 'polyvinylidene': [3789], 'difluoride': [3790], 'membrane': [3791, 3860, 3899], '(PerkinElmer': [3792], 'Life': [3793], 'Sciences),': [3794], 'immunostained': [3796], 'primary': [3798], 'antibodies': [3799, 3829, 3849], 'appropriate': [3802, 3969], 'dilutions': [3803], '(αA-crystallin': [3804], '(a': [3806], 'kind': [3807], 'gift': [3808], 'Jack': [3811], 'Liang,': [3812], 'School);': [3815], 'monoclonal': [3817], '(Lab': [3819], 'Frontier,': [3820], 'Seoul,': [3821], 'Korea);': [3822], 'TGFβ1,': [3823], 'pIκBα,': [3824], 'IκBα,': [3825], 'RelA': [3828], '(Santa': [3830, 3864], 'Cruz': [3831, 3865], 'Biotechnology,': [3832], 'Inc.,': [3833], 'Santa': [3834], 'Cruz,': [3835], 'CA);': [3836], 'pSmad3': [3837], '(BIOSOURCE': [3839], 'International': [3840], 'Inc.).': [3841, 3886], 'Membranes': [3842], 'incubated': [3844], 'horseradish': [3846], 'peroxidase-conjugated': [3847], 'secondary': [3848], '(1:1500': [3850], 'dilution).': [3851], 'Specific': [3852], 'bands': [3854], 'visualized': [3856], 'incubating': [3858], 'luminal': [3862], 'reagent': [3863], 'Biotechnology)': [3866], 'exposing': [3868], 'film': [3870], '(X-Omat;': [3871], 'Eastman': [3872], 'Kodak': [3873], 'Co.)': [3874], 'recorded': [3876], 'FUJIFILM-LAS-4000': [3879], 'luminescent': [3880], 'image': [3881, 4137], 'analyzer': [3882], '(FUJIFILM': [3883], 'Systems': [3885], 'To': [3887], 'ascertain': [3888], 'comparative': [3889], 'equal': [3892], 'loading': [3893], 'samples,': [3897], 'stained': [3900], 'stripped': [3903], 'reprobed': [3905], 'actin': [3907], '(Sigma).': [3909], '+109': [3915], '(Fig.': [3917, 3958], '1,': [3918], 'Construct': [3919, 4001, 4004, 4007, 4046, 4069, 4079, 4092], 'A)': [3920], 'mouse': [3924], 'genomic': [3925], 'DNA': [3926], 'sequenced.': [3928], 'A': [3929, 4047, 4183], 'construct': [3930], '−1139': [3932], 'bp': [3933], 'ligating': [3937], 'basic': [3940, 4119], 'pCAT': [3941], 'vector': [3942], '(Promega)': [3943], 'SacI': [3946, 3973], 'XhoI': [3948, 3978], 'sites.': [3949], 'Similarly,': [3950], 'constructs': [3951, 4287], 'deletion': [3953, 4020, 4065], 'sizes': [3957], '2,': [3959], 'Constructs': [3960, 4010], 'B': [3961, 4070], 'C)': [3963, 4172], 'primers': [3971, 4200], 'bearing': [3972], 'reverse': [3975], 'primer': [3976], 'made': [3980], 'plasmid': [3988, 4115, 4247], 'amplified': [3990], 'CAT': [3995, 4028, 4104, 4258], 'assay.': [3996], 'Primers': [3997], 'Afor,': [4002], '5′-CTGAGAGCTCCTGCCATGTTC-3′;': [4003], 'Bfor,': [4005], '5′-CTTCCTCTGGAGCTCAGAATTTAC-3′;': [4006], 'Cfor,': [4008], '5′-CACAGAGCTCGTTCTTGCCACATC-3′;': [4009], 'A,': [4011, 4093], 'B,': [4012, 4094], 'Crev,': [4014], '5′-CAGGAACTCGAGGAAGCGGAT-3′.FIGURE': [4015], '2Transcriptional': [4016], 'linked': [4026], 'Prdx6+/+': [4030], 'top': [4035], 'drawing': [4036], 'illustrates': [4037], 'transcription-binding': [4040], 'consists': [4048], '(NF-κB-1': [4053, 4161], 'NF-κB-2)': [4055], '(RSBE-1': [4061], 'RSBE-2).': [4063], 'Two': [4064], 'generated:': [4068], 'one': [4072, 4082], 'C': [4080], 'only.': [4085], 'transiently': [4088], 'transfected': [4089], 'Prdx6-CAT': [4091, 4195, 4285], 'After': [4097], '72': [4098], 'h,': [4099], 'extracted,': [4102], 'measured.': [4107], 'transfection': [4109], 'efficiencies': [4110], 'normalized': [4112], 'secreted': [4116], 'alkaline': [4117], 'phosphatase': [4118], 'vector.': [4120], 'data': [4122], 'represent': [4123], 'mean': [4125], '±': [4126], 'S.D.': [4127], 'three': [4129], 'independent': [4130], 'experiments.View': [4131], 'Large': [4132], 'Image': [4133], 'Figure': [4134], 'ViewerDownload': [4135], 'Hi-res': [4136], 'Download': [4138], '(PPT)': [4139], 'PCR-based': [4140], 'site-directed': [4141, 4149], 'mutagenesis': [4142, 4150], 'QuikChangeTM': [4148], 'kit': [4151, 4265], '(Stratagene),': [4152], 'following': [4153, 4198], "company's": [4155], 'protocol.': [4156], 'Briefly,': [4157], 'amino': [4158], 'acid': [4159], 'exchanges': [4160], '(negative': [4162], 'strand)': [4163], 'NF-κB-2': [4165], '(CC': [4166], 'AA': [4168, 4179], 'G': [4170, 4185], 'RSBE/TIE-1': [4174], '-2': [4176], '(GG': [4177], 'T': [4181], 'C))': [4187], 'mutations': [4192], 'constructs.': [4196], 'complementary': [4199], '(changed': [4203], 'nucleotides': [4204], 'boldface': [4207], 'underlined):': [4210], 'NF-κB-Mut-1for,': [4211], '5′-GATTGGACCTAGGGCCTCCCACACTCCAGTCAAG-3′;': [4212], 'NF-κB-Mut-1Rev,': [4213], '5′-CTTGACTGGAGTGTGGGAGGCCCTAGGTCCAATC-3′;': [4214], 'NF-κB-Mut-2for,': [4215], '5′-CATTTCTTCAGGTGGGAATTCACTGCATACAC-3′;': [4216], 'NF-κB-Mut-2Rev,': [4217], '5′-GTGTATGCAGTCAATTCGCACCTGAAGAAATG-3′;': [4218], 'RSBE/TIE-1-MutFor,': [4219], '5′-CCCTCTTATTGACATTGGTACAGAATGTTTGCTGC-3′;': [4220], 'RSBE/TIE-1-MutRev,': [4221], '5′-GCAGCAAACATTCTGTACCAATGTCAATAAGAGGG-3′;': [4222], 'RSBE/TIE-2-MutFor,': [4223], '5′-CTTCTGAAACCCAGGTTGGCTGAGTAGTCAGTC-3′;': [4224], 'RSBE.TIE-2-MutRev,': [4225], '5′-GACTGACTACTCAGCCAACCTGGGTTTCAGAAG-3′.': [4226], 'Epicuran': [4227], 'Coli': [4228], 'XL1-Blue': [4229], 'super-competent': [4230], '(Stratagene)': [4232], 'transformed': [4234], 'resultant': [4236], 'plasmid,': [4237], 'clones': [4239], 'grown': [4241], 'Luria-Bertani/Amp': [4243], 'Petri': [4244], 'dishes.': [4245], 'amplified,': [4249], 'mutation': [4252], 'confirmed': [4254], 'sequencing.': [4256], 'performed': [4261], 'CAT-ELISA': [4264], '(Roche': [4266], 'Applied': [4267], 'Science).': [4268], 'their': [4276], 'respective': [4277], 'transfected/co-transfected': [4281], 'Superfectamine': [4283], 'reporter': [4286], '1': [4289], 'μg': [4290], 'SEAP': [4292], 'vector,': [4293], 'Pub': [4313]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2062250649', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-08T17:33:43.018057', 'created_date': '2016-06-24'}
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