Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2061963890', 'doi': 'https://doi.org/10.1016/j.neuint.2008.08.012', 'title': 'Acute effects of combining citalopram and pindolol on regional brain serotonin synthesis in sham operated and olfactory bulbectomized rats', 'display_name': 'Acute effects of combining citalopram and pindolol on regional brain serotonin synthesis in sham operated and olfactory bulbectomized rats', 'publication_year': 2008, 'publication_date': '2008-11-28', 'ids': {'openalex': 'https://openalex.org/W2061963890', 'doi': 'https://doi.org/10.1016/j.neuint.2008.08.012', 'mag': '2061963890', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19073228', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2693021'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.neuint.2008.08.012', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S53315755', 'display_name': 'Neurochemistry International', 'issn_l': '0197-0186', 'issn': ['0197-0186', '1872-9754'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc2693021?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5083394481', 'display_name': 'Khanh Q. Nguyen', 'orcid': 'https://orcid.org/0000-0002-5378-6671'}, 'institutions': [{'id': 'https://openalex.org/I5023651', 'display_name': 'McGill University', 'ror': 'https://ror.org/01pxwe438', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I5023651']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Khanh Q. Nguyen', 'raw_affiliation_strings': ['Department of Neurology and Neurosurgery, McGill University , Montreal, Quebec, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology and Neurosurgery, McGill University , Montreal, Quebec, Canada', 'institution_ids': ['https://openalex.org/I5023651']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069693469', 'display_name': 'Yoshihiro Tohyama', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I5023651', 'display_name': 'McGill University', 'ror': 'https://ror.org/01pxwe438', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I5023651']}, {'id': 'https://openalex.org/I1292859797', 'display_name': 'Montreal Neurological Institute and Hospital', 'ror': 'https://ror.org/05ghs6f64', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1292859797']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Yoshihiro Tohyama', 'raw_affiliation_strings': ['Cone Neurological Research Laboratory, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada'], 'affiliations': [{'raw_affiliation_string': 'Cone Neurological Research Laboratory, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada', 'institution_ids': ['https://openalex.org/I5023651', 'https://openalex.org/I1292859797']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102141858', 'display_name': 'Arata Watanabe', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I5023651', 'display_name': 'McGill University', 'ror': 'https://ror.org/01pxwe438', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I5023651']}, {'id': 'https://openalex.org/I1292859797', 'display_name': 'Montreal Neurological Institute and Hospital', 'ror': 'https://ror.org/05ghs6f64', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1292859797']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Arata Watanabe', 'raw_affiliation_strings': ['Cone Neurological Research Laboratory, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada'], 'affiliations': [{'raw_affiliation_string': 'Cone Neurological Research Laboratory, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada', 'institution_ids': ['https://openalex.org/I5023651', 'https://openalex.org/I1292859797']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015931466', 'display_name': 'Shu Hasegawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I5023651', 'display_name': 'McGill University', 'ror': 'https://ror.org/01pxwe438', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I5023651']}, {'id': 'https://openalex.org/I1292859797', 'display_name': 'Montreal Neurological Institute and Hospital', 'ror': 'https://ror.org/05ghs6f64', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1292859797']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Shu Hasegawa', 'raw_affiliation_strings': ['Cone Neurological Research Laboratory, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada'], 'affiliations': [{'raw_affiliation_string': 'Cone Neurological Research Laboratory, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada', 'institution_ids': ['https://openalex.org/I5023651', 'https://openalex.org/I1292859797']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076319326', 'display_name': 'Ivan Skelin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I5023651', 'display_name': 'McGill University', 'ror': 'https://ror.org/01pxwe438', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I5023651']}, {'id': 'https://openalex.org/I1292859797', 'display_name': 'Montreal Neurological Institute and Hospital', 'ror': 'https://ror.org/05ghs6f64', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1292859797']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Ivan Skelin', 'raw_affiliation_strings': ['Cone Neurological Research Laboratory, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada'], 'affiliations': [{'raw_affiliation_string': 'Cone Neurological Research Laboratory, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada', 'institution_ids': ['https://openalex.org/I5023651', 'https://openalex.org/I1292859797']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5083969851', 'display_name': 'Mirko Dikšić', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1292859797', 'display_name': 'Montreal Neurological Institute and Hospital', 'ror': 'https://ror.org/05ghs6f64', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1292859797']}, {'id': 'https://openalex.org/I5023651', 'display_name': 'McGill University', 'ror': 'https://ror.org/01pxwe438', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I5023651']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Mirko Diksic', 'raw_affiliation_strings': ['Cone Neurological Research Laboratory, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada'], 'affiliations': [{'raw_affiliation_string': 'Cone Neurological Research Laboratory, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada', 'institution_ids': ['https://openalex.org/I1292859797', 'https://openalex.org/I5023651']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3540, 'currency': 'USD', 'value_usd': 3540, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.535, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 16, 'citation_normalized_percentile': {'value': 0.63215, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 86, 'max': 87}, 'biblio': {'volume': '54', 'issue': '3-4', 'first_page': '161', 'last_page': '171'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10056', 'display_name': 'Neurobiological Mechanisms of Drug Addiction and Depression', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10056', 'display_name': 'Neurobiological Mechanisms of Drug Addiction and Depression', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10077', 'display_name': 'Molecular Mechanisms of Synaptic Plasticity and Neurological Disorders', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10448', 'display_name': 'Neural Mechanisms of Memory Formation and Spatial Navigation', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/2805', 'display_name': 'Cognitive Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pindolol', 'display_name': 'Pindolol', 'score': 0.8507173}, {'id': 'https://openalex.org/keywords/citalopram', 'display_name': 'Citalopram', 'score': 0.68697184}, {'id': 'https://openalex.org/keywords/receptor-activation', 'display_name': 'Receptor Activation', 'score': 0.451896}], 'concepts': [{'id': 'https://openalex.org/C2778499207', 'wikidata': 'https://www.wikidata.org/wiki/Q418101', 'display_name': 'Pindolol', 'level': 3, 'score': 0.8507173}, {'id': 'https://openalex.org/C2777490545', 'wikidata': 'https://www.wikidata.org/wiki/Q409672', 'display_name': 'Citalopram', 'level': 4, 'score': 0.68697184}, {'id': 'https://openalex.org/C2775864247', 'wikidata': 'https://www.wikidata.org/wiki/Q167934', 'display_name': 'Serotonin', 'level': 3, 'score': 0.6832329}, {'id': 'https://openalex.org/C2780496858', 'wikidata': 'https://www.wikidata.org/wiki/Q644945', 'display_name': 'Olfactory bulb', 'level': 3, 'score': 0.46486574}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.45551673}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.43839633}, {'id': 'https://openalex.org/C201792869', 'wikidata': 'https://www.wikidata.org/wiki/Q1054094', 'display_name': 'Olfactory system', 'level': 2, 'score': 0.4341176}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.36575618}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.36521477}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.36231214}, {'id': 'https://openalex.org/C15744967', 'wikidata': 'https://www.wikidata.org/wiki/Q9418', 'display_name': 'Psychology', 'level': 0, 'score': 0.27091384}, {'id': 'https://openalex.org/C529278444', 'wikidata': 'https://www.wikidata.org/wiki/Q47273', 'display_name': 'Central nervous system', 'level': 2, 'score': 0.14296669}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.05743888}, {'id': 'https://openalex.org/C2778151854', 'wikidata': 'https://www.wikidata.org/wiki/Q423364', 'display_name': 'Propranolol', 'level': 2, 'score': 0.057283044}], 'mesh': [{'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D015283', 'descriptor_name': 'Citalopram', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D003866', 'descriptor_name': 'Depressive Disorder', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D010869', 'descriptor_name': 'Pindolol', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D012701', 'descriptor_name': 'Serotonin', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017660', 'descriptor_name': 'Autoreceptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017660', 'descriptor_name': 'Autoreceptors', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017660', 'descriptor_name': 'Autoreceptors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D015283', 'descriptor_name': 'Citalopram', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003714', 'descriptor_name': 'Denervation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003866', 'descriptor_name': 'Depressive Disorder', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003866', 'descriptor_name': 'Depressive Disorder', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003866', 'descriptor_name': 'Depressive Disorder', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004357', 'descriptor_name': 'Drug Synergism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004359', 'descriptor_name': 'Drug Therapy, Combination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025461', 'descriptor_name': 'Feedback, Physiological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025461', 'descriptor_name': 'Feedback, Physiological', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D025461', 'descriptor_name': 'Feedback, Physiological', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009830', 'descriptor_name': 'Olfactory Bulb', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009830', 'descriptor_name': 'Olfactory Bulb', 'qualifier_ui': 'Q000601', 'qualifier_name': 'surgery', 'is_major_topic': False}, {'descriptor_ui': 'D010869', 'descriptor_name': 'Pindolol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017729', 'descriptor_name': 'Presynaptic Terminals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017729', 'descriptor_name': 'Presynaptic Terminals', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017729', 'descriptor_name': 'Presynaptic Terminals', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D011903', 'descriptor_name': 'Raphe Nuclei', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011903', 'descriptor_name': 'Raphe Nuclei', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D011903', 'descriptor_name': 'Raphe Nuclei', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044282', 'descriptor_name': 'Receptor, Serotonin, 5-HT1A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044282', 'descriptor_name': 'Receptor, Serotonin, 5-HT1A', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012701', 'descriptor_name': 'Serotonin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058829', 'descriptor_name': 'Serotonin 5-HT1 Receptor Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012702', 'descriptor_name': 'Serotonin Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012702', 'descriptor_name': 'Serotonin Antagonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D017367', 'descriptor_name': 'Serotonin Uptake Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017367', 'descriptor_name': 'Serotonin Uptake Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009435', 'descriptor_name': 'Synaptic Transmission', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009435', 'descriptor_name': 'Synaptic Transmission', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D009435', 'descriptor_name': 'Synaptic Transmission', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.neuint.2008.08.012', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S53315755', 'display_name': 'Neurochemistry International', 'issn_l': '0197-0186', 'issn': ['0197-0186', '1872-9754'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2693021', 'pdf_url': 'https://europepmc.org/articles/pmc2693021?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693021', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19073228', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2693021', 'pdf_url': 'https://europepmc.org/articles/pmc2693021?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.85}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 101, 'referenced_works': ['https://openalex.org/W1483189311', 'https://openalex.org/W1492266111', 'https://openalex.org/W1553235867', 'https://openalex.org/W1624425219', 'https://openalex.org/W1646726516', 'https://openalex.org/W1661406670', 'https://openalex.org/W1965454331', 'https://openalex.org/W1968187794', 'https://openalex.org/W1968901038', 'https://openalex.org/W1970663646', 'https://openalex.org/W1972223203', 'https://openalex.org/W1972324473', 'https://openalex.org/W1974044036', 'https://openalex.org/W1979912423', 'https://openalex.org/W1981691052', 'https://openalex.org/W1986874860', 'https://openalex.org/W1986881967', 'https://openalex.org/W1989446622', 'https://openalex.org/W1992395370', 'https://openalex.org/W1995617429', 'https://openalex.org/W1996567997', 'https://openalex.org/W1998113639', 'https://openalex.org/W1999721747', 'https://openalex.org/W2001023145', 'https://openalex.org/W2007046516', 'https://openalex.org/W2008164876', 'https://openalex.org/W2008980764', 'https://openalex.org/W2012729010', 'https://openalex.org/W2013725545', 'https://openalex.org/W2014643424', 'https://openalex.org/W2017221228', 'https://openalex.org/W2018008180', 'https://openalex.org/W2020640680', 'https://openalex.org/W2023873361', 'https://openalex.org/W2025073729', 'https://openalex.org/W2028727536', 'https://openalex.org/W2029003010', 'https://openalex.org/W2029699398', 'https://openalex.org/W2029748309', 'https://openalex.org/W2031008625', 'https://openalex.org/W2035632600', 'https://openalex.org/W2036902158', 'https://openalex.org/W2038859823', 'https://openalex.org/W2039534965', 'https://openalex.org/W2040798945', 'https://openalex.org/W2041465605', 'https://openalex.org/W2043219628', 'https://openalex.org/W2043226949', 'https://openalex.org/W2045605252', 'https://openalex.org/W2047476622', 'https://openalex.org/W2047627032', 'https://openalex.org/W2048283236', 'https://openalex.org/W2051068515', 'https://openalex.org/W2052451375', 'https://openalex.org/W2052970369', 'https://openalex.org/W2054111879', 'https://openalex.org/W2054637652', 'https://openalex.org/W2055797693', 'https://openalex.org/W2058470067', 'https://openalex.org/W2059368872', 'https://openalex.org/W2066036825', 'https://openalex.org/W2069608774', 'https://openalex.org/W2073248538', 'https://openalex.org/W2074411049', 'https://openalex.org/W2076639163', 'https://openalex.org/W2076981513', 'https://openalex.org/W2079612535', 'https://openalex.org/W2081423757', 'https://openalex.org/W2084240947', 'https://openalex.org/W2085325217', 'https://openalex.org/W2089958533', 'https://openalex.org/W2093477760', 'https://openalex.org/W2094526136', 'https://openalex.org/W2098163527', 'https://openalex.org/W2098949907', 'https://openalex.org/W2100700955', 'https://openalex.org/W2102579252', 'https://openalex.org/W2113521179', 'https://openalex.org/W2117763749', 'https://openalex.org/W2118713264', 'https://openalex.org/W2125509251', 'https://openalex.org/W2128257083', 'https://openalex.org/W2131167630', 'https://openalex.org/W2137667198', 'https://openalex.org/W2143808576', 'https://openalex.org/W2147643047', 'https://openalex.org/W2154958489', 'https://openalex.org/W2155132989', 'https://openalex.org/W2159399023', 'https://openalex.org/W2159612818', 'https://openalex.org/W2163815564', 'https://openalex.org/W2164389817', 'https://openalex.org/W2165833361', 'https://openalex.org/W2168358363', 'https://openalex.org/W2171267699', 'https://openalex.org/W2341365624', 'https://openalex.org/W2398413879', 'https://openalex.org/W2406298202', 'https://openalex.org/W2425238338', 'https://openalex.org/W2938326', 'https://openalex.org/W322494530'], 'related_works': ['https://openalex.org/W4231815232', 'https://openalex.org/W3160004761', 'https://openalex.org/W2378430301', 'https://openalex.org/W2072939200', 'https://openalex.org/W2072856858', 'https://openalex.org/W2072365414', 'https://openalex.org/W2060063624', 'https://openalex.org/W2045914711', 'https://openalex.org/W2020093956', 'https://openalex.org/W2009608443'], 'abstract_inverted_index': {'The': [0, 50, 73], 'olfactory': [1], 'bulbectomized': [2], '(OBX)': [3], 'rat': [4], 'is': [5, 53, 247], 'considered': [6], 'to': [7, 55, 157, 187, 208, 235], 'be': [8, 42, 88, 280], 'a': [9, 96, 169], 'good': [10], 'model': [11], 'of': [12, 15, 20, 24, 35, 59, 75, 93, 257, 272, 284], 'the': [13, 21, 69, 91, 105, 178, 255], 'pathology': [14], 'human': [16, 266, 277], 'depression': [17, 278], 'and': [18, 135, 173, 180, 240, 252, 270], 'also': [19], 'functional': [22], 'actions': [23], 'antidepressant': [25, 33, 274], 'drug': [26], 'therapy.': [27], 'It': [28], 'has': [29], 'been': [30], 'proposed': [31], 'that': [32, 216], 'effects': [34, 219, 228, 259, 291], 'selective': [36], 'serotonin': [37], 'reuptake': [38], 'inhibitors': [39], '(SSRIs)': [40], 'can': [41, 87], 'accelerated': [43], 'by': [44, 231, 282], 'blocking': [45], '5-HT(1A/B)': [46, 232, 244, 285], 'autoreceptors': [47], 'with': [48, 145, 159, 191, 195, 210], 'pindolol.': [49], 'underlying': [51], 'mechanism': [52], 'thought': [54], 'involve': [56], 'acute': [57, 112, 217], 'unrestricting': [58], '5-HT': [60, 66, 79, 94, 224], 'release': [61], 'and,': [62, 263], 'consequently,': [63], 'relatively': [64], 'enhanced': [65], 'turnover': [67, 80], 'throughout': [68], 'forebrain': [70], 'serotonergic': [71, 102, 121, 129, 293], 'networks.': [72], 'effect': [74], 'this': [76], 'combination': [77], 'on': [78, 292], 'in': [81, 101, 153, 204, 221, 238, 249, 260, 265], 'sham': [82, 110, 154, 239], 'operated': [83], 'or': [84], 'OBX': [85, 163, 188, 205, 241, 250, 261], 'rats': [86, 155, 189, 206, 251, 262], 'assessed': [89], 'at': [90, 118, 128, 150, 168, 177, 200], 'level': [92], 'synthesis,': [95, 225], 'very': [97], 'important': [98], 'presynaptic': [99], 'step': [100], 'neurotransmission,': [103], 'using': [104], 'alpha-[(14)C]methyl-l-tryptophan': [106], 'autoradiography': [107], 'method.': [108], 'In': [109, 162], 'rats,': [111, 164], 'citalopram': [113, 146, 165, 196, 218], '(20mg/kg)': [114], 'treatment': [115, 158, 209], 'increased': [116, 148, 198], 'synthesis': [117, 127, 149, 167, 176, 199], 'almost': [119, 201], 'all': [120, 202], 'terminal': [122, 171, 223], 'regions': [123, 132, 152, 172, 203], 'but': [124, 226], 'slightly': [125], 'decreased': [126, 166, 175], 'cell': [130], 'body': [131], '(i.e.': [133], 'dorsal': [134, 179], 'median': [136, 181], '(not': [137], 'significant)': [138], 'raphe;': [139], 'approximately': [140, 184], '16%).': [141], 'Combining': [142, 193], 'pindolol': [143, 194], '(10mg/kg)': [144], 'further': [147], 'many': [151], '(relative': [156, 207], 'only': [160, 211], 'citalopram).': [161, 212], 'few': [170], 'greatly': [174, 197], 'raphe': [182], '(': [183], '45%;': [185], 'relative': [186], 'treated': [190], 'saline).': [192], 'These': [213], 'results': [214], 'suggest': [215], 'result': [220], 'elevated': [222], 'these': [227], 'are': [229], 'restrained': [230], 'autoreceptor': [233, 245, 286], 'feedback': [234, 246], 'different': [236], 'degrees': [237], 'rats.': [242], 'Moreover,': [243], 'stronger': [248], 'may': [253, 279], 'underlie': [254], 'delay': [256], 'SSRI': [258, 273, 290], 'correspondingly,': [264], 'depression.': [267], 'Pindolol': [268], 'acceleration': [269], 'augmentation': [271], 'therapy': [275], 'for': [276], 'mediated': [281], 'attenuation': [283], 'feedback,': [287], 'permitting': [288], 'unhindered': [289], 'terminals.': [294]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2061963890', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-09-25T00:57:28.767671', 'created_date': '2016-06-24'}