Title: Fluorine substituent effects (on bioactivity)
Abstract: The characteristic effects of fluorine and fluoroalkyl substituents on the physico-chemical properties of molecules that are important to biological activity of fluorinated compounds are highlighted. The influence of fluorination on acidity, hydrogen-bonding, and lipophilicity that affect compound absorption and distribution is described. The current perspectives on fluorine steric interactions and the controversial role of hydrogen-bonding involving the CF bond are discussed.
Publication Year: 2001
Publication Date: 2001-06-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 1368
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