Title: Studies on the cellular and molecular mechanisms of hydrocarbon carcinogenesis
Abstract: Abstract The author has reviewed his research carried out over the past 20 years concerned with the cellular mechanisms of hydrocarbon carcinogenesis. The interaction of labeled carcinogenic hydrocarbons with the DNA, RNA, and proteins of mouse skin has been studied at various times after topical application, and the results correlated with the carcinogenic process. A quantitative system, employing cells derived from C3H mouse ventral prostate, has been developed for obtaining malignant transformation in vitro with carcinogenic hydrocarbons. A mechanism involving the selection of preexisting malignant cells by the carcinogen has been ruled out with this system.
Publication Year: 1970
Publication Date: 1970-06-01
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 36
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