Title: The uptake and content of digitoxin and its metabolites in the heart muscle of rats and guinea-pigs after acute and chronic application
Abstract: On the basis of the xanthydrol reaction and a highly sensitive thin-film chromatographic detection method, content and composition of glycoside metabolites were determined in the heart muscle and in the blood of rats and guinea-pigs after single and repeated i.p. injections of digitoxin. In the guinea-pig's heart we found a maximum of 1 μg/g, in the rat's heart 7–8 μg glycoside/g heart muscle. A pre-treatment by reserpine did not influence the uptake of digitoxin. Digitoxin metabolites, inclusive of genins, were found in the heart muscle most frequently 14–24 hr after application of digitoxin, C12-hydroxylation products 6 hr at the earliest after injection. The proportion of metabolites was always relatively small in comparison with unchanged digitoxin. After subacute digitoxin injection the proportion of digitoxin in the heart muscle was much bigger than after only one injection. If the content of digitoxin and its metabolites was compared in the blood and in the heart muscle, a correlation with the digitoxigenin derivatives would be seen. The digoxigenin derivatives, almost without exception, were more frequently detected in the blood rather than in the heart muscle.
Publication Year: 1967
Publication Date: 1967-07-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 4
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