Involvement of Toll-like Receptors 2 and 4 in Cellular Activation by High Mobility Group Box 1 Protein

Name: Work Video:
Duration: 3 min 30 s
Jong Sung Park; Daiva Svetkauskaite; Qianbin He; Jae‐Yeol Kim; Derek Strassheim; Akitoshi Ishizaka; Edward Abraham
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'https://openalex.org/W1996061474'], 'abstract_inverted_index': {'High': [0, 237], 'mobility': [1, 238, 481], 'group': [2, 239, 482], 'box': [3, 240, 483], '1': [4, 241, 1222, 3506, 3565, 3568, 3577, 3580, 3583, 3608, 3669, 3695, 3933, 3962], '(HMGB1)': [5, 242], 'protein,': [6, 243], 'originally': [7, 244, 551], 'described': [8, 245, 552, 2971], 'as': [9, 95, 97, 157, 246, 332, 334, 394, 553, 1199, 1241, 1243, 2143, 2145, 2262, 2264, 2557, 2559, 2969, 3229, 3242, 3703, 4016, 4111, 4554], 'a': [10, 199, 247, 436, 554, 634, 657, 691, 1681, 2045, 2573, 2920, 3060, 3076, 3196, 3200, 3265, 3519, 3704, 3812, 3870, 4055, 4176, 4183], 'DNA-binding': [11, 248], 'protein': [12, 249, 520, 534, 545, 558, 668, 2734, 2739, 2762, 3625, 3895, 3905], 'that': [13, 180, 229, 250, 417, 466, 1216, 1485, 1509, 1556, 1645, 2477, 2488, 2569, 2679, 4095, 4112, 4187, 4337, 4396], 'stabilizes': [14, 251], 'nucleosomes': [15, 252], 'and': [16, 43, 92, 137, 140, 147, 183, 213, 253, 280, 329, 374, 377, 384, 420, 450, 682, 690, 738, 913, 985, 1237, 1342, 1345, 1488, 1493, 1534, 1554, 1561, 1569, 1633, 1642, 1822, 2140, 2150, 2255, 2267, 2554, 2586, 2602, 2630, 2712, 2737, 2751, 2798, 2834, 2849, 2952, 2956, 3057, 3070, 3095, 3114, 3132, 3139, 3180, 3211, 3273, 3305, 3378, 3397, 3406, 3465, 3478, 3480, 3513, 3590, 3623, 3645, 3694, 3733, 3740, 3787, 3791, 3865, 3889, 3945, 3961, 4031, 4150, 4169, 4285, 4349, 4380, 4429, 4433, 4437, 4474, 4534, 4556, 4568], 'facilitates': [17, 254], 'transcription,': [18, 255, 723], 'can': [19, 256, 727, 4459], 'also': [20, 257, 1523, 2258], 'be': [21, 258, 718, 1516, 1652, 2591], 'released': [22, 259], 'extracellularly': [23, 260], 'during': [24, 261], 'acute': [25, 262, 914], 'inflammatory': [26, 227, 263, 464, 907, 1097, 1100, 2617], 'responses.': [27, 264], 'Exposure': [28, 265], 'of': [29, 41, 46, 86, 105, 113, 127, 134, 144, 169, 192, 208, 223, 266, 278, 283, 323, 342, 350, 364, 371, 381, 406, 429, 445, 460, 660, 666, 674, 696, 722, 1081, 1089, 1188, 1207, 1325, 1352, 1490, 1496, 1500, 1512, 1519, 1547, 1563, 1567, 1572, 1663, 1684, 1688, 1814, 1825, 2037, 2042, 2480, 2485, 2535, 2550, 2592, 2597, 2609, 2612, 2782, 2847, 2859, 2931, 2944, 2958, 3059, 3067, 3101, 3150, 3169, 3268, 3300, 3331, 3425, 3447, 3459, 3531, 3610, 3680, 3683, 3692, 3697, 3725, 3924, 3964, 4046, 4051, 4097, 4104, 4132, 4147, 4192, 4200, 4272, 4297, 4316, 4355, 4369, 4391, 4422, 4427, 4443, 4462], 'neutrophils,': [30, 267, 4323], 'monocytes,': [31, 268, 2261, 3138, 3210], 'or': [32, 107, 269, 344, 995, 1105, 1504, 3279, 3285, 3503, 3615, 4456], 'macrophages': [33, 108, 270, 345, 986, 1208, 1831, 3212], 'to': [34, 61, 71, 225, 232, 271, 298, 308, 462, 469, 704, 717, 904, 1193, 1232, 1336, 1346, 1348, 1532, 1559, 1640, 1695, 1816, 1819, 2040, 2136, 2250, 2590, 2614, 2677, 3177, 3221, 3296, 3345, 3526, 3710, 3747, 4099, 4106, 4182, 4268, 4276, 4374, 4409, 4418, 4469], 'HMGB1': [35, 67, 110, 129, 209, 224, 272, 304, 347, 366, 446, 461, 474, 632, 642, 672, 702, 726, 900, 999, 1084, 1194, 1228, 1503, 1533, 1641, 1698, 1815, 2490, 2520, 2540, 2598, 2613, 2773, 3278, 3288, 3504, 4042, 4100, 4136, 4348, 4416], 'results': [36, 273, 1085, 1211, 3542, 4188, 4335, 4394], 'in': [37, 100, 132, 166, 189, 202, 274, 337, 369, 403, 426, 439, 669, 688, 700, 709, 732, 906, 1086, 1212, 1214, 1530, 1628, 1635, 1654, 1666, 2562, 2576, 2852, 3089, 3215, 3258, 3554, 3642, 3648, 3762, 3835, 3897, 3921, 3974, 4135, 4153, 4189, 4281, 4321, 4327, 4344, 4357, 4387, 4404, 4431, 4562], 'increased': [38, 124, 275, 361, 4101, 4275, 4326, 4352], 'nuclear': [39, 276, 557, 1350, 1494, 1565, 3756, 4102, 4270, 4295, 4314, 4353, 4389, 4420], 'translocation': [40, 277, 1351, 1495, 1566, 1637, 4271, 4354, 4421], 'NF-κB': [42, 114, 279, 351, 1353, 1497, 1581, 1636, 2043, 4047, 4105, 4155, 4273, 4298, 4317, 4356, 4468, 4548, 4566], 'enhanced': [44, 281, 1349, 1570, 1823, 4419], 'expression': [45, 282, 1324, 1492, 1521, 1571, 1824, 3332], 'proinflammatory': [47, 284, 1189, 1326, 1573], 'cytokines.': [48, 285], 'Although': [49, 286, 1625, 4118, 4543], 'the': [50, 79, 84, 125, 167, 221, 287, 316, 321, 362, 404, 458, 645, 663, 1087, 1322, 1338, 1486, 1538, 1548, 1626, 1658, 1661, 1685, 2146, 2532, 2543, 2548, 2610, 2674, 2780, 2853, 2857, 2942, 3050, 3055, 3071, 3084, 3106, 3145, 3178, 3216, 3219, 3326, 3346, 3527, 3532, 3678, 3723, 3741, 3758, 3792, 3806, 3815, 3875, 3890, 3898, 3955, 4108, 4130, 4145, 4190, 4197, 4278, 4313, 4375, 4388, 4444, 4463, 4472], 'receptor': [51, 89, 153, 288, 326, 390, 512, 1541, 1674, 4180], 'for': [52, 220, 289, 457, 513, 1240, 1321, 1544, 1675, 2749, 3105, 3116, 3130, 3157, 3182, 3354, 3473, 3505, 3545, 3617, 3631, 3712, 3798, 3825, 3883, 3918, 3954, 3993, 4020, 4126, 4194, 4547], 'advanced': [53, 290, 514, 1676], 'glycation': [54, 291, 515, 1677], 'end': [55, 292, 516, 1678], 'products': [56, 293, 1679], '(RAGE)': [57, 294], 'has': [58, 295, 633, 714, 901, 1669, 1692, 2133], 'been': [59, 76, 296, 313, 715, 902, 1671, 1693, 2134, 2525, 4141], 'shown': [60, 297, 716, 1694, 2135, 3544], 'interact': [62, 299, 1696], 'with': [63, 109, 175, 210, 300, 346, 412, 447, 640, 1083, 1196, 1201, 1209, 1502, 1697, 2599, 2669, 3064, 3098, 3144, 3248, 3275, 3291, 3500, 3607, 3948, 3986, 4116, 4120, 4305, 4311], 'HMGB1,': [64, 301, 479, 2580, 4269], 'other': [65, 302, 2538, 4339, 4398, 4457], 'putative': [66, 303, 2539], 'receptors': [68, 305, 2491, 2521, 4338, 4397], 'are': [69, 230, 306, 467, 1217, 3543, 4014, 4123, 4402, 4439], 'known': [70, 307], 'exist': [72, 309, 2492], 'but': [73, 150, 310, 387, 1102, 1334, 1526, 4324], 'have': [74, 311, 705, 2522, 2530], 'not': [75, 151, 312, 388, 1103, 1527, 1670, 2523, 4139, 4319, 4383], 'characterized.': [77, 314], 'In': [78, 194, 315, 431, 1445, 2032, 2248, 2542, 4290, 4307], 'present': [80, 317, 2252, 2544, 4300], 'experiments,': [81, 318, 2545], 'we': [82, 319, 1483, 2546, 4093, 4157, 4424], 'explored': [83, 320, 2547], 'role': [85, 201, 322, 438, 665, 731, 1662, 2549, 2575], 'RAGE,': [87, 324, 511, 2551], 'Toll-like': [88, 325], '(TLR)': [90, 327], '2,': [91, 163, 328, 400, 2553], 'TLR': [93, 116, 145, 148, 181, 184, 211, 214, 330, 353, 382, 385, 418, 421, 448, 451, 1539, 1649, 1664, 2552, 2555, 2584, 2587, 2600, 2603, 2684, 2707, 2869, 4052, 4121, 4133, 4148, 4151, 4164, 4178, 4201, 4341, 4360, 4370, 4376, 4400], '4,': [94, 149, 331, 386, 1650, 2556], 'well': [96, 333, 2144, 2263, 2558], 'associated': [98, 335, 2560], 'kinases,': [99, 336, 2142, 2561], 'HMGB1-induced': [101, 190, 338, 427, 1667, 2478, 2563, 4345], 'cellular': [102, 339, 670, 710, 1513, 1655, 2564, 4128, 4346, 4405, 4453], 'activation.': [103, 340, 2565, 4347], 'Culture': [104, 341, 1080, 2957], 'neutrophils': [106, 343, 1501, 2961, 3220, 3759, 4098, 4159, 4282, 4328, 4358, 4373], 'produced': [111, 348], 'activation': [112, 133, 191, 204, 349, 370, 428, 441, 1514, 1546, 1656, 2041, 2578, 4406, 4426, 4549, 4567], 'through': [115, 352, 2044, 2583, 2683, 3075, 3223, 3811, 4048], '4-independent': [117, 354], 'mechanisms.': [118, 355], 'Unlike': [119, 356], 'lipopolysaccharide': [120, 357, 989], '(LPS),': [121, 358, 990], 'which': [122, 359, 733, 4415], 'primarily': [123, 360, 4124], 'activity': [126, 363, 3515, 4477], 'IKKβ,': [128, 365, 1555], 'exposure': [130, 367, 1192, 1229, 1639, 4096, 4267, 4368, 4408, 4454], 'resulted': [131, 368], 'both': [135, 187, 372, 424, 4291, 4351], 'IKKα': [136, 373, 1553, 2750, 4428, 4436, 4544], 'IKKβ.': [138, 375], 'Kinases': [139, 376], 'scaffolding': [141, 378], 'proteins': [142, 379, 3373], 'downstream': [143, 380], '2': [146, 182, 212, 383, 419, 449, 1235, 2585, 2601, 2708, 2870, 3634, 3659, 4152, 4165, 4361, 4371, 4401], 'TLR/interleukin-1': [152, 389], '(IL-1R)-independent': [154, 391], 'kinases': [155, 392, 1344], 'such': [156, 393, 2518, 4553], 'tumor': [158, 395, 492, 736, 991], 'necrosis': [159, 396, 493, 992], 'factor': [160, 162, 397, 399, 993], 'receptor-associated': [161, 398], 'were': [164, 186, 401, 423, 1506, 2632, 2717, 2742, 2753, 2842, 2850, 2919, 2928, 2935, 2939, 2962, 3062, 3073, 3087, 3175, 3213, 3256, 3289, 3337, 3351, 3374, 3498, 3510, 3535, 3552, 3605, 3629, 3638, 3731, 3760, 3794, 3817, 3833, 3892, 3913, 3968, 3984], 'involved': [165, 188, 402, 425, 1653, 4403], 'enhancement': [168, 405], 'NF-κB-dependent': [170, 407], 'transcription': [171, 408, 1577], 'by': [172, 205, 235, 409, 442, 472, 648, 988, 1328, 1657, 1829, 2579, 2620, 2779, 2805, 2941, 3199, 3224, 3231, 3244, 3339, 3677, 3722, 3735, 3808, 3819, 4002, 4414, 4551], 'HMGB1.': [173, 206, 410, 443, 4306, 4410], 'Transfections': [174, 411], 'dominant': [176, 413, 3370], 'negative': [177, 414, 3225, 3371], 'constructs': [178, 415], 'demonstrated': [179, 416, 903, 1524], '4': [185, 215, 422, 452, 1540, 1665, 2588, 2604, 2685, 3120, 3163, 3186, 3621, 3829, 3887, 4053, 4122, 4134, 4149, 4179, 4202, 4342], 'NF-κB.': [193, 430, 4392], 'contrast,': [195, 432, 4308], 'RAGE': [196, 433, 1817, 2038, 2131, 2257, 2486, 2536, 2570], 'played': [197, 434], 'only': [198, 435, 649, 1230, 2572, 2681], 'minor': [200, 437, 2574], 'macrophage': [203, 440, 1096, 1099, 2577, 3310], 'Interactions': [207, 444, 2596], 'may': [216, 453, 2605], 'provide': [217, 454, 2606], 'an': [218, 455, 719, 729, 2607, 3158, 3632, 3748], 'explanation': [219, 456, 2608], 'ability': [222, 459, 2611], 'generate': [226, 463], 'responses': [228, 465, 2618], 'similar': [231, 468, 1646], 'those': [233, 470, 3286], 'initiated': [234, 471, 2619, 3676], 'LPS.': [236, 473, 1535, 2621, 3282, 4117], '1The': [475], 'abbreviations': [476], 'used': [477, 3360], 'are:': [478], 'high': [480], '1;': [484], 'IRAK,': [485], 'IL-1R-associated': [486], 'kinase': [487, 538, 546, 1550, 1631, 3649, 3673, 3684, 4446], 'family;': [488], 'LPS,': [489, 4312], 'lipopolysaccharide;': [490], 'TNF,': [491], 'factor;': [494], 'IL-1,': [495, 4557], 'interleukin-1;': [496], 'ERK,': [497, 1340], 'extracellular': [498, 730], 'signal-regulated': [499], 'kinase;': [500, 504, 510, 521, 535, 539, 542], 'JNK,': [501, 1341], 'c-Jun': [502], 'amino-terminal': [503], 'TLR,': [505], 'Tell-like': [506], 'receptor;': [507], 'IKK,': [508], 'IκB': [509, 4445, 4464], 'products;': [517], 'SAPK,': [518], 'stress-activated': [519], 'PGN,': [522], 'peptidoglycan;': [523], 'PAM,': [524], 'tripamitoyl': [525, 2713], 'lipopeptide': [526, 2714], 'PAM3-Cys-Ser-Lys4;': [527], 'E2,': [528], 'ubiquitin': [529], 'carrier': [530], 'protein;': [531], 'MAPK,': [532], 'mitogen-activated': [533, 544], 'MAPKKK,': [536], 'MAPK': [537], 'NIK,': [540], 'NF-κB-inducing': [541], 'MKK,': [543], 'kinase.': [547], '(formerly': [548], 'HMG1)': [549], 'was': [550, 2643, 2655, 2666, 2725, 2763, 2774, 3155, 3192, 3235, 3251, 3315, 3361, 3516, 3675, 3708, 3720, 3744, 3803, 3877, 3900, 4000, 4034, 4039, 4274, 4299, 4318, 4325], 'non-histone,': [555], 'chromatin-associated': [556], '(1Agresti': [559], 'A.': [560, 617, 782, 810, 922, 950, 972, 1013, 1046, 1068, 1120, 1153, 1175, 1283, 1305, 1436, 1712, 4204, 4537], 'Bianchi': [561, 620, 785, 849], 'M.E.': [562, 621, 786, 850], 'Curr.': [563, 1598], 'Opin.': [564], 'Genet.': [565], 'Dev.': [566], '2003;': [567, 837, 1369, 1404, 1475, 1847, 1998, 2167, 3014, 3040, 4085], '13:': [568], '170-178Crossref': [569], 'PubMed': [570, 603, 627, 768, 792, 825, 840, 855, 879, 894, 932, 979, 1028, 1075, 1135, 1182, 1265, 1312, 1372, 1407, 1440, 1478, 1591, 1605, 1620, 1728, 1764, 1788, 1808, 1850, 1892, 1914, 1938, 1967, 2001, 2029, 2067, 2095, 2126, 2170, 2192, 2214, 2243, 2308, 2330, 2359, 2385, 2416, 2444, 2469, 2512, 2701, 2793, 2823, 2882, 2912, 3017, 3043, 4088, 4236, 4261, 4499, 4527], 'Scopus': [571, 628, 793, 826, 841, 856, 880, 895, 933, 980, 1029, 1076, 1136, 1183, 1266, 1313, 1373, 1408, 1441, 1479, 1592, 1606, 1621, 1729, 1765, 1789, 1809, 1851, 1893, 1915, 1939, 2002, 2068, 2096, 2127, 2171, 2193, 2215, 2244, 2309, 2331, 2386, 2417, 2445, 2470, 2513, 2702, 2794, 2824, 2883, 2913, 3018, 3044, 4089, 4237, 4262, 4500, 4528], '(329)': [572], 'Google': [573, 589, 604, 630, 754, 769, 795, 828, 843, 858, 882, 897, 935, 982, 1031, 1078, 1138, 1185, 1268, 1315, 1375, 1410, 1443, 1481, 1594, 1608, 1623, 1731, 1748, 1767, 1791, 1811, 1853, 1895, 1917, 1941, 1968, 2004, 2030, 2070, 2098, 2129, 2173, 2195, 2217, 2246, 2311, 2333, 2360, 2388, 2419, 2447, 2472, 2515, 2704, 2796, 2826, 2885, 2915, 2994, 3020, 3046, 4091, 4239, 4264, 4502, 4530], 'Scholar,': [574, 590, 605, 755, 770, 796, 829, 844, 859, 883, 936, 1032, 1139, 1269, 1376, 1411, 1595, 1609, 1732, 1749, 1768, 1792, 1854, 1896, 1918, 1942, 1969, 2005, 2071, 2099, 2174, 2196, 2218, 2312, 2334, 2361, 2389, 2420, 2448, 2886, 2995, 3021, 4240, 4503, 4531], '2Andersson': [575], 'U.': [576, 741, 798, 966, 1001, 1062, 1108, 1169, 1299, 1434], 'Erlandsson-Harris': [577, 742, 807, 1010, 1117], 'H.': [578, 580, 594, 743, 745, 759, 800, 808, 816, 861, 863, 885, 887, 924, 938, 952, 1003, 1011, 1019, 1034, 1048, 1110, 1118, 1126, 1141, 1155, 1247, 1249, 1271, 1285, 1384, 1386, 1417, 1455, 1457, 1742, 1902, 1922, 1924, 2019, 2055, 2180, 2202, 2318, 2432, 2894, 2896, 4065, 4067], 'Yang': [579, 744, 815, 862, 951, 1018, 1047, 1125, 1154, 1248, 1284, 1383, 1387, 1416, 1422, 1454, 1458, 2974, 4064, 4068], 'Tracey': [581, 595, 746, 760, 817, 832, 868, 888, 925, 973, 1020, 1069, 1127, 1176, 1254, 1306, 1395, 1428, 1466, 4076], 'K.J.': [582, 596, 747, 761, 818, 833, 869, 889, 926, 974, 1021, 1070, 1128, 1177, 1255, 1307, 1396, 1429, 1467, 4077, 4250], 'J.': [583, 597, 623, 748, 762, 788, 819, 871, 920, 927, 948, 964, 1022, 1044, 1060, 1129, 1151, 1167, 1257, 1281, 1297, 1380, 1400, 1451, 1471, 1614, 1738, 1758, 1784, 1858, 1864, 1876, 1881, 1903, 1927, 1952, 2007, 2011, 2020, 2056, 2084, 2109, 2111, 2117, 2120, 2181, 2200, 2203, 2224, 2274, 2280, 2292, 2297, 2319, 2344, 2374, 2399, 2401, 2407, 2410, 2424, 2433, 2508, 2696, 2815, 2877, 2973, 2979, 2988, 2999, 3001, 3029, 3038, 4061, 4081, 4255, 4488, 4516], 'Leukoc.': [584, 749, 2989], 'Biol.': [585, 750, 1882, 1904, 1928, 2021, 2057, 2085, 2182, 2204, 2298, 2320, 2375, 2434, 2819, 2990, 4489, 4517], '2002;': [586, 751, 852, 1437, 1602, 1725, 1745, 1785, 1805, 1930, 2206, 2509, 2991], '72:': [587, 752, 2992], '1084-1091PubMed': [588, 753], '3Czura': [591, 756], 'C.J.': [592, 757, 831, 865, 1251, 1425], 'Wang': [593, 758, 799, 886, 923, 1002, 1109, 1385, 1456, 4066], 'Endotoxin': [598, 763, 1615], 'Res.': [599, 764, 1616, 1744, 2788], '2001;': [600, 624, 765, 789, 876, 891, 1262, 1588, 1761, 2240], '7:': [601, 766], '315-321Crossref': [602, 767], '4Muller': [606, 771], 'S.': [607, 772, 954, 1050, 1157, 1287, 1359, 1435, 1585, 1613, 1780, 1837, 1872, 1956, 1985, 1989, 1993, 2157, 2288, 2348, 2454, 2504, 2876, 2902, 3035, 3037, 4248, 4507], 'Scaffidi': [608, 773], 'P.': [609, 774, 846, 4227, 4252], 'Degryse': [610, 775], 'B.': [611, 776, 1770, 2494, 4229, 4231], 'Bonaldi': [612, 777], 'T.': [613, 778, 848, 1702, 1860, 1977, 1991, 2276, 2892, 2898, 4511], 'Ronfani': [614, 779], 'L.': [615, 780, 956, 1052, 1159, 1289, 1413, 1704, 2222, 2238, 4244, 4536], 'Agresti': [616, 781], 'Beltrame': [618, 783], 'M.': [619, 784, 814, 942, 946, 1017, 1038, 1042, 1124, 1145, 1149, 1275, 1279, 1357, 1361, 1415, 1419, 1772, 1774, 1778, 1835, 1839, 1868, 1960, 1979, 1981, 2017, 2155, 2159, 2284, 2352, 2458, 2496, 2498, 2502, 2687, 3470, 4221, 4225, 4509], 'EMBO': [622, 787], '20:': [625, 790], '4337-4340Crossref': [626, 791], '(384)': [629, 794], 'Scholar).': [631, 898, 983, 1079, 1186, 1316, 1444, 1624, 1812, 2031, 2130, 2247, 2473, 2516, 2705, 2827, 3047, 4265, 4542], 'highly': [635, 692], 'conserved': [636], 'sequence': [637], 'among': [638], 'species,': [639], 'murine': [641], 'differing': [643], 'from': [644, 2634, 2645, 2657, 2673, 2719, 2727, 2744, 2755, 2765, 2776, 2922, 2964, 3083, 3380, 3399, 3408, 3417, 3432, 3442, 3452, 3467, 3482, 3805, 4160, 4283, 4329, 4359, 4559], 'human': [646], 'form': [647], 'two': [650, 675, 706, 1659], 'amino': [651, 686, 698], 'acids.': [652], 'HMGB1-deficient': [653], 'mice': [654, 2841, 2867, 2927, 4162, 4174, 4287, 4331, 4363, 4560], 'die': [655], 'within': [656, 1219, 4196], 'few': [658], 'hours': [659], 'birth,': [661], 'demonstrating': [662], 'crucial': [664], 'this': [667, 3706], 'function.': [671], 'consists': [673], 'tandem': [676], 'L-shaped': [677], 'domains,': [678], 'HMGB': [679], 'boxes': [680], 'A': [681], 'B,': [683], 'each': [684, 3355, 3546, 4021], '∼75': [685], 'acids': [687, 699], 'length,': [689], 'acidic': [693], 'carboxyl': [694], 'terminus': [695], '30': [697, 3681, 3713, 3716], 'length.': [701], 'appears': [703, 2589], 'distinct': [707], 'functions': [708], 'systems.': [711], 'First,': [712], 'it': [713, 734], 'intracellular': [720], 'regulator': [721], 'and,': [724], 'second,': [725], 'occupy': [728], 'promotes': [735], 'metastasis': [737], 'inflammation': [739], '(2Andersson': [740], '5Andersson': [797], 'Palmblad': [801, 1004, 1111], 'K.': [802, 1005, 1112, 1958, 1973, 1975, 1983, 1987, 2350, 2456, 2874, 2890, 2900, 3027, 4515], 'Aveberger': [803, 1006, 1113], 'A.C.': [804, 1007, 1114], 'Bloom': [805, 939, 1008, 1035, 1115, 1142, 1272], 'O.': [806, 940, 1009, 1036, 1116, 1143, 1273, 1583, 1856, 1946, 2079, 2103, 2232, 2272, 2338, 2369, 2393, 2450, 2872, 2888], 'Janson': [809, 1012, 1119], 'Kokkola': [811, 1014, 1121], 'R.': [812, 1015, 1122, 1423, 1862, 1948, 2013, 2113, 2278, 2340, 2403, 2430], 'Zhang': [813, 941, 1016, 1037, 1123, 1144, 1274, 1863, 2110, 2225, 2279, 2400], 'Exp.': [820, 1023, 1130, 4256], 'Med.': [821, 836, 875, 1024, 1131, 1261, 4257], '2000;': [822, 929, 1025, 1132, 1617, 2436, 2698, 2879], '192:': [823, 1026, 1133], '565-570Crossref': [824, 1027, 1134], '(1254)': [827, 1030, 1137], '6Czura': [830], 'Crit.': [834, 873, 1259], 'Care': [835, 874, 1260, 2951], '31:': [838], 'S46-S50Crossref': [839], '(54)': [842], '7Scaffidi': [845], 'Misteli': [847], 'Nature.': [851], '418:': [853], '191-195Crossref': [854], '(3459)': [857], '8Wang': [860], 'Czura': [864, 1250, 1424], 'Sama': [866, 971, 1067, 1174, 1252, 1304], 'A.E.': [867, 1253], 'Am.': [870, 1256, 1399, 1470, 2814, 4080], 'Respir.': [872, 1258, 2816], '164:': [877, 1263], '1768-1773Crossref': [878, 1264], '(427)': [881, 1267], '9Yang': [884], 'Shock.': [890], '15:': [892, 3015], '247-253Crossref': [893], '(139)': [896], 'Extracellular': [899], 'participate': [905, 4343], 'processes,': [908], 'including': [909, 1552, 1648], 'delayed': [910, 1197, 1323], 'endotoxin': [911], 'lethality': [912], 'lung': [915], 'injury': [916], '(10Abraham': [917], 'E.': [918, 960, 962, 1056, 1058, 1163, 1165, 1293, 1295, 1363, 1398, 1469, 1706, 1782, 1841, 2009, 2161, 2506, 2813, 2987, 3011, 3023, 3420, 4079, 4219], 'Arcaroli': [919, 1379, 1450, 2998, 3028, 4060], 'Carmody': [921], 'Immunol.': [928, 1601, 2697, 2878, 3039], '165:': [930, 2699, 2880], '2950-2954Crossref': [931], '(652)': [934], '11Wang': [937, 1033, 1140, 1270], 'Vishnubhakat': [943, 1039, 1146, 1276], 'J.M.': [944, 1040, 1147, 1277, 2075, 2365], 'Ombrellino': [945, 1041, 1148, 1278], 'Che': [947, 1043, 1150, 1280], 'Frazier': [949, 1045, 1152, 1282], 'Ivanova': [953, 1049, 1156, 1286], 'Borovikova': [955, 1051, 1158, 1288], 'Manogue': [957, 1053, 1160, 1290], 'K.R.': [958, 1054, 1161, 1291], 'Faist': [959, 1055, 1162, 1292], 'Abraham': [961, 1057, 1164, 1294, 1397, 1468, 2812, 2986, 3010, 4078], 'Andersson': [963, 965, 1059, 1061, 1166, 1168, 1296, 1298], 'Molina': [967, 1063, 1170, 1300], 'P.E.': [968, 1064, 1171, 1301], 'Abumrad': [969, 1065, 1172, 1302], 'N.N.': [970, 1066, 1173, 1303], 'Science.': [975, 1071, 1178, 1308, 4232], '1999;': [976, 1072, 1179, 1309, 1906, 2059, 2184, 2322, 2904, 4258, 4519], '285:': [977, 1073, 1180, 1310], '248-251Crossref': [978, 1074, 1181, 1311], '(3020)': [981, 1077, 1184, 1314], 'Monocytes': [984], 'stimulated': [987, 3274, 3499], '(TNF)-α,': [994], 'interleukin-1': [996], '(IL-1)': [997], 'secrete': [998], '(5Andersson': [1000, 1107], 'monocytes': [1082], 'release': [1088], 'TNF-α,': [1090], 'IL-1α,': 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3080, 3188, 3202, 3357, 3367, 3508, 3599, 3636, 3672, 3718, 3831, 3894, 3966], 'signaling': [1318, 1668, 2582, 2680, 4137], 'mechanisms': [1319, 1511, 4413], 'responsible': [1320, 1543, 4125], 'HMGB1-stimulated': [1329, 4032], 'cells': [1330, 2270, 2482, 3072, 3497, 3509, 4558], 'remain': [1331], 'incompletely': [1332], 'explained': [1333], 'appear': [1335], 'involve': [1337], 'p38,': [1339, 2139], 'Akt': [1343], 'lead': [1347], '(12Fiuza': [1354, 1832, 2152], 'C.': [1355, 1736, 1833, 1900, 2053, 2153, 2178, 2316, 2785, 4213, 4223, 4505], 'Bustin': [1356, 1834, 2154], 'Talwar': [1358, 1836, 2156], 'Tropea': [1360, 1838, 2158], 'Gerstenberger': [1362, 1840, 2160], 'Shelhamer': [1364, 1842, 2162], 'J.H.': [1365, 1843, 2163, 2691], 'Suffredini': [1366, 1844, 2164], 'A.F.': [1367, 1845, 2165], 'Blood.': [1368, 1846, 2166], '101:': [1370, 1848, 2168], '2652-2660Crossref': [1371, 1849, 2169], '(669)': [1374, 1852, 2172], '13Park': [1377], 'J.S.': [1378, 1449, 2077, 2367, 2983, 3005, 3033, 4059], 'Yum': [1381, 1452, 2976, 4062], 'H.K.': [1382, 1453, 2977, 4063], 'K.Y.': [1388, 1459, 2975, 2997, 4069], 'Choe': [1389, 1460, 4070], 'K.H.': [1390, 1461, 4071], 'Strassheim': [1391, 1462, 2984, 3030, 4072], 'D.': [1392, 1421, 1463, 1776, 1794, 1874, 1878, 1962, 2119, 2290, 2294, 2354, 2409, 2460, 2500, 2985, 3007, 3031, 4073, 4217, 4254, 4513], 'Pitts': [1393, 1464, 2980, 3002, 4074], 'T.M.': [1394, 1465, 2981, 3003, 4075], 'Physiol.': [1401, 1403, 1472, 1474, 4082, 4084], 'Cell': [1402, 1473, 1721, 2817, 3126, 4083], '284:': [1405, 1476, 4086], 'C870-C879Crossref': [1406, 1477, 4087], '(390)': [1409, 1480, 4090], '14Ulloa': [1412], 'Ochani': [1414], 'Tanovic': [1418], 'Halperin': [1420], 'Fink': [1426], 'M.P.': [1427], 'Proc.': [1430], 'Natl.': [1431], 'Acad.': [1432], 'Sci.': [1433, 1724], '99:': [1438], '12351-12356Crossref': [1439], '(545)': [1442], 'recent': [1446, 2475], 'studies': [1447, 2529, 2567], '(13Park': [1448, 4058], 'Scholar),': [1482, 4092], 'found': [1484, 4094], 'magnitude': [1487], 'cytokine': [1491, 1574], 'similar,': [1507], 'suggesting': [1508], 'overlapping': [1510], 'might': [1515, 1651], 'involved.': [1517], 'Comparison': [1518], 'gene': [1520, 1629], 'arrays': [1522], 'substantial': [1525], 'complete': [1528], 'homology': [1529], 'response': [1531], 'Signaling': [1536], 'via': [1537], 'is': [1542, 1578, 2483, 3128, 4545], 'IKK': [1549], 'complex,': [1551], 'leads': [1558, 1818, 2039, 4417], 'phosphorylation': [1560], 'degradation': [1562], 'IκB,': [1564], 'NF-κB,': [1568, 4423], 'genes': [1575], 'whose': [1576], 'dependent': [1579], 'on': [1580, 2253, 2260, 3317, 3325, 3796, 3873, 3970], '(15Takeuchi': [1582], 'Akira': [1584, 2875, 2901], 'Int.': [1586], 'Immunopharmacol.': [1587], '1:': [1589], '625-635Crossref': [1590], '(404)': [1593], "16O'Neill": [1596], 'L.A.': [1597], 'Top.': [1599], 'Microbiol.': [1600], '270:': [1603, 1885, 2301], '47-61Crossref': [1604], '(254)': [1607], '17Zhang': [1610], 'G.': [1611, 1920, 1926, 2426, 4246], 'Ghosh': [1612], '6:': [1618], '453-457Crossref': [1619], '(190)': [1622], 'similarity': [1627], 'expression,': [1630], 'activation,': [1632, 4129, 4156], 'patterns': [1634], 'suggest': [1644], 'receptors,': [1647], 'stimuli,': [1660, 4458], 'reported.': [1672], '(RAGE),': [1680], 'multi-ligand': [1682], 'member': [1683], 'immunoglobulin': [1686], 'superfamily': [1687], 'cell': [1689, 2034, 2967, 3053, 3081, 3107, 3190, 3311], 'surface': [1690, 3108], 'molecules,': [1691], '(18Bucciarelli': [1699], 'L.G.': [1700], 'Wendt': [1701], 'Rong': [1703], 'Lalla': [1705], 'Hofmann': [1707], 'M.A.': [1708, 4479], 'Goova': [1709], 'M.T.': [1710, 2234], 'Taguchi': [1711], 'Yan': [1713, 1715, 1752, 1754, 1795, 1797, 1949, 2114, 2341, 2404, 2451], 'S.F.': [1714, 1755, 1798], 'S.D.': [1716, 1753, 1796, 1950, 2115, 2342, 2405, 2452], 'Stern': [1717, 1756, 1877, 1961, 2118, 2293, 2353, 2408, 2459], 'D.M.': [1718, 1757], 'Schmidt': [1719, 1799, 1879, 2082, 2295, 2372, 2461], 'A.M.': [1720, 1751, 1800, 1880, 1944, 2083, 2101, 2296, 2336, 2373, 2391, 2462, 4485], 'Mol.': [1722, 2818], 'Life': [1723], '59:': [1726], '1117-1128Crossref': [1727], '(267)': [1730], '19Huttunen': [1733], 'H.J.': [1734, 1898, 2051, 2176, 2198, 2314, 2422], 'Fages': [1735, 1899, 2052, 2177, 2315], 'Kuja-Panula': [1737, 2199, 2423], 'Ridley': [1739], 'A.J.': [1740], 'Rauvala': [1741, 1901, 1923, 2018, 2054, 2179, 2201, 2317, 2431], 'Cancer': [1743], '62:': [1746], '4805-4811PubMed': [1747], '20Schmidt': [1750], 'Clin.': [1759, 2121, 2411], 'Invest.': [1760, 2122, 2412], '108:': [1762], '949-955Crossref': [1763], '(1081)': [1766], '21Sparatore': [1769], 'Pedrazzi': [1771, 2495], 'Passalacqua': [1773, 2497], 'Gaggero': [1775, 2499], 'Patrone': [1777, 2501], 'Pontremoli': [1779, 2503], 'Melloni': [1781, 2505], 'Biochem.': [1783, 2507, 2786], '363:': [1786, 2510], '529-535Crossref': [1787, 2511], '(29)': [1790, 2514], '22Stern': [1793], 'Adv.': [1801], 'Drug': [1802], 'Deliv.': [1803], 'Rev.': [1804], '54:': [1806], '1615-1625Crossref': [1807], '(250)': [1810], 'Binding': [1813], 'neurite': [1820], 'outgrowth': [1821], 'tissue-type': [1826], 'plasminogen': [1827], 'activator': [1828], 'transformed': [1830], '23Hori': [1855], 'Brett': [1857, 1951, 2116, 2273, 2343, 2406], 'Slattery': [1859, 2275], 'Cao': [1861, 1947, 2112, 2277, 2339, 2402], 'Chen': [1865, 2104, 2281, 2394], 'J.X.': [1866, 2105, 2282, 2395], 'Nagashima': [1867, 2283], 'Lundh': [1869, 2285], 'E.R.': [1870, 2286], 'Vijay': [1871, 2287], 'Nitecki': [1873, 2289], 'Morser': [1875, 2291], 'Chem.': [1883, 1905, 1929, 2022, 2058, 2086, 2183, 2205, 2299, 2321, 2376, 2435, 4490, 4518], '1995;': [1884, 2123, 2300, 2413, 2820], '25752-25761Abstract': [1886, 2302], 'Full': [1887, 1889, 1909, 1911, 1933, 1935, 2026, 2062, 2064, 2090, 2092, 2187, 2189, 2209, 2211, 2303, 2305, 2325, 2327, 2380, 2382, 2439, 2441, 2907, 2909, 4494, 4496, 4522, 4524], 'Text': [1888, 1890, 1910, 1912, 1934, 1936, 2027, 2063, 2065, 2091, 2093, 2188, 2190, 2210, 2212, 2304, 2306, 2326, 2328, 2381, 2383, 2440, 2442, 2908, 2910, 4495, 4497, 4523, 4525], 'PDF': [1891, 1913, 1937, 2028, 2066, 2094, 2191, 2213, 2307, 2329, 2384, 2443, 2911, 4498, 4526], '(1044)': [1894, 2310], '24Huttunen': [1897, 2175, 2313], '274:': [1907, 2060, 2185, 2323, 4520], '19919-19924Abstract': [1908, 2061, 2186, 2324], '(580)': [1916, 2069, 2194, 2332], '25Sajithlal': [1919], 'Huttunen': [1921], 'Munch': [1925], '277:': [1931, 2207], '6888-6897Abstract': [1932], '(48)': [1940], '26Schmidt': [1943, 2335], 'Hori': [1945, 2078, 2102, 2337, 2368, 2392], 'Wautier': [1953, 2345], 'J.L.': [1954, 2346], 'Ogawa': [1955, 2347, 2453, 2897], 'Kuwabara': [1957, 2349, 2455], 'Matsumoto': [1959, 2351, 2457], 'Diabetes.': [1963, 2239, 2355], '1996;': [1964, 2356, 2466], '45:': [1965, 2357], 'S77-S80Crossref': [1966, 2358], '27Taniguchi': [1970], 'N.': [1971, 4487], 'Kawahara': [1972], 'Yone': [1974], 'Hashiguchi': [1976], 'Yamakuchi': [1978], 'Goto': [1980], 'Inoue': [1982], 'Yamada': [1984], 'Ijiri': [1986], 'Matsunaga': [1988], 'Nakajima': [1990], 'Komiya': [1992], 'Maruyama': [1994], 'I.': [1995, 4208], 'Arthritis': [1996], 'Rheum.': [1997], '48:': [1999], '971-981Crossref': [2000], '(434)': [2003], '28Parkkinen': [2006], 'Raulo': [2008], 'Merenmies': [2010], 'Nolo': [2012], 'Kajander': [2014], 'E.O.': [2015], 'Baumann': [2016], '1993;': [2023], '268:': [2024], '19726-19738Abstract': [2025], 'these': [2033], 'populations,': [2035], 'engagement': [2036], 'redox-dependent': [2046], 'pathway': [2047], 'involving': [2048], 'Ras': [2049], '(24Huttunen': [2050], '29Lander': [2072, 2362], 'H.M.': [2073, 2363], 'Tauras': [2074, 2364], 'Ogiste': [2076, 2366], 'Moss': [2080, 2370], 'R.A.': [2081, 2371], '1997;': [2087, 2377], '272:': [2088, 2378], '17810-17814Abstract': [2089, 2379], '(691)': [2097, 2387], '30Schmidt': [2100, 2390], 'Li': [2106, 2396], 'J.F.': [2107, 2397], 'Crandall': [2108, 2398], '96:': [2124, 2414], '1395-1403Crossref': [2125, 2415], '(829)': [2128, 2418], 'ligation': [2132], 'activate': [2137], 'ERK1/2,': [2138], 'SAPK/JNK': [2141], 'small': [2147], 'GTPases,': [2148], 'Rac': [2149], 'cdc42': [2151], '31Huttunen': [2197], '38635-38646Abstract': [2208], '(152)': [2216], '32Yeh': [2219], 'C.H.': [2220], 'Sturgis': [2221], 'Haidacher': [2223], 'X.N.': [2226], 'Sherwood': [2227], 'S.J.': [2228], 'Bjercke': [2229], 'R.J.': [2230], 'Juhasz': [2231], 'Crow': [2233], 'Tilton': [2235], 'R.G.': [2236], 'Denner': [2237], '50:': [2241], '1495-1504Crossref': [2242], '(296)': [2245], 'addition': [2249, 3679, 3724], 'being': [2251], 'neurites': [2254], 'macrophages,': [2256], 'exists': [2259], 'glioma,': [2265], 'endothelial,': [2266], 'smooth': [2268], 'muscle': [2269], '(23Hori': [2271], '33Huttunen': [2421], 'Sorci': [2425], 'Agneletti': [2427], 'A.L.': [2428], 'Donato': [2429], '275:': [2437], '40096-40105Abstract': [2438], '(523)': [2446], '34Hori': [2449], 'Nephrol.': [2463], 'Dial.': [2464], 'Transplant.': [2465], '11:': [2467, 2905], '13-16Crossref': [2468], '(70)': [2471], 'finding': [2476], 'differentiation': [2479], 'erythroleukemia': [2481], 'independent': [2484], 'indicates': [2487], 'additional': [2489, 3159, 3633], '(21Sparatore': [2493], 'However,': [2517], 'RAGE-independent': [2519], 'yet': [2524], 'identified.': [2526], 'Additionally,': [2527], 'no': [2528], 'examined': [2531, 4425], 'relative': [2533], 'importance': [2534, 4146], 'versus': [2537], 'receptors.': [2541], 'Our': [2566], 'demonstrate': [2568, 4336], 'plays': [2571], 'much': [2593], 'greater': [2594, 3237, 3252], 'importance.': [2595], 'potentiate': [2615], 'many': [2616], 'Reagents—LipofectAMINE': [2622], '2000,': [2623], 'RPMI': [2624, 3068, 3090, 3259], '1640,': [2625], "Dulbecco's": [2626], 'modified': [2627], "Eagle's": [2628], 'medium,': [2629], 'penicillin/streptomycin': [2631], 'obtained': [2633, 2656, 2743, 2764], 'Invitrogen': [2635], 'Corp.': [2636], '(Carlsbad,': [2637], 'CA).': [2638, 2723, 2772, 3366, 4011], 'Defined': [2639], 'fetal': [2640, 3092, 3261], 'bovine': [2641], 'serum': [2642, 3094, 3263], 'purchased': [2644, 2718, 2726, 2754, 2843], 'HyClone': [2646], '(Logan,': [2647], 'Utah).': [2648], '(from': [2650], 'Escherichia': [2651], 'coli': [2652], 'O111:': [2653], 'B4)': [2654], 'Sigma': [2658], 'Chemical': [2659], 'Co.': [2660], '(St.': [2661], 'Louis,': [2662], 'MO).': [2663], 're-extracted': [2667], 'twice': [2668], 'phenol': [2670], 'precipitated': [2672], 'aqueous': [2675], 'phase': [2676], 'ensure': [2678], 'occurred': [2682], '(35Hirschfeld': [2686], 'Ma': [2688], 'Y.': [2689], 'Weis': [2690, 2694], 'Vogel': [2692], 'S.N.': [2693], 'J.J.': [2695], '618-622Crossref': [2700], '(985)': [2703], 'ligands': [2709, 4378], 'peptidoglycan': [2710], '(PGN)': [2711], 'PAM3-Cys-Ser-Lys4': [2715], '(PAM)': [2716], 'InvivoGen': [2720], '(San': [2721], 'Diego,': [2722], 'Poly(dI-dC)·poly(dI-dC)': [2724], 'Amersham': [2728], 'Biosciences': [2729], '(Piscataway,': [2730], 'NJ).': [2731], 'Coomassie-Plus': [2733], 'assay': [2735, 2740, 2807, 3522, 3906], 'reagent': [2736, 2741, 3907], 'BCA': [2738], 'Pierce': [2745], '(Rockford,': [2746], 'IL).': [2747], 'Antibodies': [2748], 'IKKβ': [2752, 4430, 4438, 4563], 'Upstate': [2756], 'Inc.': [2757, 2769], '(Lake': [2758], 'Placid,': [2759], 'NY).': [2760], 'IκBα': [2761, 3698], 'Santa': [2766], 'Cruz': [2767, 3700], 'Biotechnology,': [2768], '(Santa': [2770, 3699], 'Cruz,': [2771], 'purified': [2775, 2963], 'pig': [2777], 'thymus': [2778], 'method': [2781], 'Sanders': [2783], '(36Sanders': [2784], 'Biophys.': [2787], 'Commun.': [2789], '1977;': [2790], '78:': [2791], '1034-1042Crossref': [2792], '(90)': [2795], 'Scholar)': [2797, 2916], 'contained': [2799], '10': [2802, 3099, 3587, 3591, 3666, 3687, 3766, 3774, 3826, 3928, 3980], 'pg/ml': [2803], 'chromogenic': [2806], '(37Schwartz': [2808], 'M.D.': [2809], 'Repine': [2810], 'J.E.': [2811], '12:': [2821], '434-440Crossref': [2822], '(85)': [2825], 'Mice—Male': [2828], 'C3H/HeN': [2829, 4171, 4284, 4330], '(Harlan': [2830], 'Sprague-Dawley,': [2831], 'Indianapolis,': [2832], 'IN)': [2833], 'C3H/HeJ': [2835, 4173, 4286, 4322], '(Jackson': [2836], 'Laboratories,': [2837], 'Bar': [2838], 'Harbor,': [2839], 'ME)': [2840], 'at': [2844, 2856, 3119, 3162, 3185, 3264, 3320, 3537, 3594, 3620, 3715, 3821, 3828, 3879, 3886, 3915, 3979, 3996], '6': [2845], 'weeks': [2846, 2930], 'age': [2848, 2932], 'maintained': [2851], 'animal': [2854], 'colony': [2855], 'University': [2858, 2943, 3446], 'Colorado': [2860, 2945], 'Health': [2861, 2946], 'Sciences': [2862, 2947], 'Center': [2863, 2948], '(Denver,': [2864], 'CO).': [2865], 'Transgenic': [2866], 'lacking': [2868, 4163], '(38Takeuchi': [2871], 'Hoshino': [2873, 2889], '5392-5396Crossref': [2881], '(915)': [2884], '39Takeuchi': [2887], 'Kawai': [2891], 'Sanjo': [2893], 'Takada': [2895], 'Takeda': [2899], 'Immunity.': [2903], '443-451Abstract': [2906], '(2830)': [2914], '(TLR': [2917, 4166], '2–/–)': [2918], 'gift': [2921], 'Dr.': [2923, 3381, 3409, 3418, 3433, 3443, 3453, 3468, 3483], 'Shizuo': [2924], 'Akira.': [2925], 'All': [2926, 3530], '7–10': [2929], 'when': [2933, 4450], 'experiments': [2934], 'initiated.': [2936], 'Experimental': [2937], 'procedures': [2938], 'approved': [2940], 'Institutional': [2949], 'Animal': [2950], 'Use': [2953], 'Committee.': [2954], 'Isolation': [2955], 'Mouse': [2959], 'Neutrophils—Peripheral': [2960], 'bone': [2965, 3051, 3085], 'marrow': [2966, 3052, 3086], 'suspensions': [2968], 'previously': [2970, 4140], '(40Arcaroli': [2972], 'Kupfner': [2978, 3000], 'Park': [2982, 3004, 3032], '571-579PubMed': [2993], '41Yang': [2996], 'Strasshiem': [3006], 'Perng': [3008], 'R.P.': [3009], 'Cell.': [3012], 'Signal.': [3013], '225-233Crossref': [3016], '(59)': [3019], '42Abraham': [3022], 'Gyetko': [3024], 'M.R.': [3025], 'Kuhn': [3026], 'Shetty': [3034], 'Idell': [3036], '170:': [3041], '5644-5651Crossref': [3042], '(92)': [3045], 'To': [3048, 4143, 4411], 'obtain': [3049, 3755], 'suspension,': [3054], 'femur': [3056], 'tibia': [3058], 'mouse': [3061, 3309, 4292], 'flushed': [3063], '5': [3065, 3269, 3321, 3595, 3690], 'ml': [3066], '1640/penicillin/streptomycin,': [3069], 'passed': [3074], 'glass': [3077], 'wool': [3078], 'column.': [3079], 'pellets': [3082, 3832], 'resuspended': [3088, 3257], '1640/5%-defined': [3091], 'calf': [3093, 3262], 'incubated': [3097, 3181, 3606, 3795, 3914], 'μl': [3100, 3149, 3168, 3682, 3923], 'primary': [3102], 'antibodies': [3103, 3612], 'specific': [3104, 3129, 3953], 'markers': [3109], 'F4/80,': [3110], 'CD4,': [3111], 'CD45R,': [3112], 'CD5,': [3113], 'TER119': [3115], '15': [3117, 3160, 3183, 3809, 3919, 4301], 'min': [3118, 3161, 3184, 3714, 3827, 3885, 3920, 4302], '°C.': [3121, 3164, 3187, 3717, 3830, 3998], 'This': [3122], 'custom': [3123], 'mixture': [3124], '(Stem': [3125], 'Technologies)': [3127], 'T': [3131, 3203], 'B': [3133, 3205, 3293], 'cells,': [3134, 3137, 3204, 3206, 3209], 'red': [3135, 3207], 'blood': [3136, 3208], 'macrophages.': [3140], 'After': [3141, 3801, 3869, 4266], '15-min': [3142], 'incubation': [3143, 3872], 'antibody': [3146, 3153], 'mixture,': [3147], '100': [3148, 3280], 'antibiotin': [3151], 'tetrameric': [3152], 'complexes': [3154, 3967], 'added': [3156, 3176, 3630], 'Following': [3165], 'this,': [3166], '60': [3167], 'colloidal': [3170], 'magnetic': [3171], 'dextran': [3172], 'iron': [3173], 'particles': [3174], 'suspension': [3179, 3191, 3876], 'entire': [3189], 'placed': [3194], 'into': [3195, 4471], 'column': [3197], 'surrounded': [3198], 'magnet.': [3201], 'captured': [3214], 'column,': [3217], 'allowing': [3218], 'pass': [3222], 'selection': [3226], 'methods.': [3227], 'Viability,': [3228], 'determined': [3230, 3243, 3901], 'trypan': [3232], 'blue': [3233], 'exclusion,': [3234], 'consistently': [3236], '98%.': [3239, 3254], 'Neutrophil': [3240], 'purity,': [3241], 'Cytospin': [3245], 'preparations': [3246], 'stained': [3247], "Wright's": [3249], 'stain,': [3250], 'Neutrophils': [3255], '1640/10%-defined': [3260], 'final': [3266], 'concentration': [3267, 3896], '×': [3270, 3322, 3596, 3602, 3823, 3881], '106': [3271, 3597, 3603], 'cells/ml': [3272, 3324], '1000': [3276], 'ng/ml': [3277, 3281], 'Control': [3283], 'cultures': [3284], 'containing': [3287, 3686, 3765, 3838, 3927], 'supplemented': [3290], 'polymyxin': [3292], '(10': [3294], 'μg/ml)': [3295, 3336], 'block': [3297], 'any': [3298, 4385], 'effects': [3299], 'contaminating': [3301], 'endotoxin.': [3302], 'Transient': [3303], 'Transfection': [3304], 'Luciferase': [3306], 'Reporter': [3307], 'Assay—The': [3308], 'line,': [3312], 'RAW': [3313], '264.7,': [3314], 'plated': [3316], '6-well': [3318], 'plates': [3319], '105': [3323], 'day': [3327], 'before': [3328], 'transfection.': [3329], 'Combinations': [3330], 'plasmid': [3333, 3359], 'DNAs': [3334], '(1': [3335], 'transfected': [3338], 'using': [3340, 3518, 3902, 4005], 'LipofectAMINE': [3341], '2000': [3342], '(Invitrogen)': [3343, 3628], 'according': [3344, 3525], "manufacturer's": [3347, 3528], 'instructions.': [3348, 3529], 'Duplicate': [3349], 'wells': [3350], 'set': [3352], 'up': [3353], 'group.': [3356, 4023], 'reporter': [3358, 3521], 'pNF-κBluc': [3362], '(Clontech,': [3363], 'Palo': [3364], 'Alto,': [3365], 'plasmids': [3368], 'expressing': [3369], 'mutant': [3372], 'gifts:': [3375], 'MyD88-(152–296),': [3376], 'ΔIRAK-1,': [3377], 'IRAK-2-(97–590)': [3379], 'Alberto': [3382], 'Mantovani,': [3383], 'Istituto': [3384], 'di': [3385], 'Ricerche': [3386], 'Farmacologiche': [3387], 'Mario': [3388], 'Negri,': [3389], 'Milan,': [3390], 'Italy;': [3391], 'IRAK-4': [3392], '[KK213AA],': [3393], 'TRAF6-(289–522),': [3394], 'NIK[KK429,430AA],': [3395], 'IKKα[S176A],': [3396], 'IKKβ[S177A]': [3398], 'Tularik,': [3400], 'South': [3401], 'San': [3402], 'Francisco,': [3403], 'CA;': [3404], 'TAK-1[K63W]': [3405], 'TAB2[1281–2551]': [3407], 'Kuni': [3410], 'Matsumoto,': [3411], 'Nagoya': [3412], 'University,': [3413, 3437], 'Nagoya,': [3414], 'Japan;': [3415], 'p38α[TGY180–182AGF]': [3416], 'Philips': [3419], 'Scherer,': [3421], 'Albert': [3422], 'Einstein': [3423], 'College': [3424], 'Medicine,': [3426, 3460], 'New': [3427, 3438, 3461], 'York,': [3428, 3462], 'NY;': [3429, 3463], 'TIRAP': [3430], '[PH]': [3431], 'Ruslan': [3434], 'Medzhitov,': [3435], 'Yale': [3436], 'Haven,': [3439], 'CT;': [3440], 'RAGE[Δcyto]': [3441], 'Henri': [3444], 'Huttunen,': [3445], 'Helsinki,': [3448, 3449], 'Finland;': [3450], 'TRAF2-(87–501)': [3451], 'David': [3454, 3469], 'Sassoon,': [3455], 'Mount': [3456], 'Sinai': [3457], 'School': [3458], 'TLR2[P681H]': [3464], 'TLR4[P721H]': [3466], 'Under-hill,': [3471], 'Institute': [3472], 'Systems': [3474], 'Biology,': [3475], 'Seattle,': [3476], 'WA;': [3477], 'MKK3[A]': [3479], 'MKK6[A]': [3481], 'Jiahuai': [3484], 'Han,': [3485], 'Scripps': [3486], 'Research': [3487], 'Institute,': [3488], 'La': [3489], 'Jolla,': [3490], 'CA.': [3491], 'At': [3492], '48': [3493], 'transfection,': [3496], 'either': [3501], 'h.': [3507, 3635], 'lysed,': [3512], 'luciferase': [3514, 3520, 3533], 'measured': [3517], 'kit': [3523], '(Promega)': [3524], 'assays': [3534], 'repeated': [3536], 'least': [3538], 'three': [3539, 3640], 'times.': [3540], 'Representative': [3541], 'experiment.': [3547], 'Immune': [3548], 'Complex': [3549], 'Kinase': [3550], 'Assay—Cells': [3551], 'lysed': [3553], 'lysis': [3555, 3643, 3763], 'buffer': [3556, 3644, 3650, 3685, 3764, 3837, 3926, 3978], '(20': [3557, 3651], 'mm': [3558, 3563, 3566, 3569, 3574, 3578, 3581, 3584, 3652, 3657, 3660, 3663, 3667, 3670, 3767, 3772, 3775, 3778, 3781, 3785, 3840, 3845, 3848, 3851, 3859, 3862, 3867, 3929, 3934, 3937, 3940, 3943], 'Tris-HCl,': [3559, 3653], 'pH': [3560, 3654], '7.5,': [3561], '150': [3562], 'NaCl,': [3564, 3849, 3944], 'Na2EDTA,': [3567], 'EGTA,': [3570], '1%': [3571], 'Triton,': [3572], '2.5': [3573], 'sodium': [3575, 3664], 'pyrophosphate,': [3576], 'β-glycerophosphate,': [3579], 'Na3VO4,': [3582, 3786], 'phenylmethylsulfonyl': [3585, 3782, 3863], 'fluoride,': [3586, 3783, 3864], 'μg/ml': [3588, 3592], 'aprotinin,': [3589], 'leupeptin)': [3593], 'cells/ml.': [3598], 'lysates': [3600], '(5': [3601, 3911], 'cells/sample)': [3604], 'μg': [3609, 3696, 3963], 'polyclonal': [3611], '(either': [3613], 'anti-IKKα': [3614], 'anti-IKKβ)': [3616], '3': [3618], '°C,': [3622, 3888], 'G-Sepharose': [3626], 'beads': [3627, 3637], 'washed': [3639], 'times': [3641], 'once': [3647], '7.4;': [3655], '20': [3656, 3799, 3839, 3884, 3922], 'MgCl2;': [3658], 'EGTA;': [3661], '0.5': [3662, 3777, 3780, 3858, 3861, 3936, 3939], 'vanadate;': [3665], 'β-glycerophosphate;': [3668], 'dithiothreitol).': [3671], 'reaction': [3674, 3719, 3925], 'μm': [3688], 'ATP,': [3689], 'μCi': [3691], '[32P]ATP,': [3693], 'Biotechnology': [3701], 'Inc.)': [3702], 'substrate;': [3705], 'step': [3707], 'allowed': [3709], 'proceed': [3711], 'terminated': [3721], '5×': [3726], 'SDS': [3727], 'sample': [3728], 'buffer.': [3729], 'Samples': [3730], 'boiled': [3732], 'resolved': [3734, 3969], '10%': [3736], 'SDS-polyacrylamide': [3737], 'gel': [3738, 3743], 'electrophoresis,': [3739], 'fixed': [3742], 'exposed': [3746, 3985], 'x-ray': [3749], 'film.': [3750], 'Electrophoretic': [3751], 'Mobility': [3752], 'Shift': [3753], 'Assays—To': [3754], 'extracts,': [3757], 'suspended': [3761, 3834], 'Tris·HCl': [3768, 3841, 3930, 3975], '(pH': [3769, 3842, 3931, 3976], '7.5),': [3770, 3843, 3932], '1.5': [3771, 3844], 'MgCl2,': [3773, 3846, 3935], 'KCl,': [3776], 'dithiothreitol,': [3779, 3941], '0.1': [3784, 3866], '0.1%': [3788, 3853], 'Triton': [3789, 3854], 'X-100,': [3790, 3855], 'samples': [3793], 'ice': [3797], 'min.': [3800], 'cytoplasm': [3802], 'removed': [3804], 'nuclei': [3807, 3816], 'passages': [3810], '25-gauge': [3813], 'needle,': [3814], 'collected': [3818], 'centrifugation': [3820], '5,000': [3822], 'g': [3824, 3882], 'extraction': [3836], '420': [3847], '0.2': [3850], 'EDTA,': [3852, 3860, 3938], '25%': [3856], 'glycerol,': [3857], 'Na3VO4.': [3868], '30-min': [3871], 'ice,': [3874], 'centrifuged': [3878], '14,000': [3880], 'supernatants': [3891, 3899], 'collected.': [3893], 'Coomassie': [3903], 'Plus': [3904], '(Pierce).': [3908], 'Nuclear': [3909, 4044], 'extracts': [3910], 'μg)': [3912], 'room': [3916], 'temperature': [3917], '50': [3942], '4%': [3946], 'glycerol': [3947], '32P-end-labeled,': [3949], 'double-stranded': [3950], 'oligonucleotide': [3951], 'probe': [3952], 'κB': [3956], 'site,': [3957], '5′-GCCATGGGGGGATCCCCGAAGTCC-3′': [3958], '(Geneka': [3959], 'Biotechnology)': [3960], 'poly(dI-dC)·poly(dI-dC).': [3965], '5%': [3971], 'polyacrylamide': [3972], 'gels': [3973, 3983], '8.0)-borate-EDTA': [3977], 'V/cm.': [3981], 'Dried': [3982], 'Kodak': [3987], 'Biomax': [3988], 'MS': [3989], 'film': [3990], '(Rochester,': [3991], 'NY)': [3992], '1–24': [3994], '70': [3997], 'Quantification': [3999], 'performed': [4001], 'image': [4003], 'analysis': [4004], 'densitometry': [4006], '(ChemiDoc': [4007], 'system;': [4008], 'Bio-Rad,': [4009], 'Hercules,': [4010], 'Statistical': [4012], 'Analysis—Data': [4013], 'presented': [4015], 'mean': [4017], '±': [4018], 'S.E.': [4019], 'experimental': [4022], "Student's": [4024], 't': [4025], 'test': [4026], '(for': [4027], 'comparisons': [4028], 'between': [4029], 'LPS-': [4030], 'cells)': [4033], 'used.': [4035], 'p': [4036], '<': [4037], '0.05': [4038], 'considered': [4040], 'significant.': [4041], 'Enhances': [4043], 'Translocation': [4045], 'Mechanisms': [4049], 'Independent': [4050], '—In': [4054], 'previous': [4056], 'study': [4057], 'accumulation': [4103, 4296], 'approximately': [4107, 4277], 'same': [4109, 4279], 'level': [4110], 'seen': [4113], 'stimulation': [4115, 4304], 'interactions': [4119], 'involvement': [4131], 'had': [4138], 'determined.': [4142], 'examine': [4144], 'HMGB1-associated': [4154], 'utilized': [4158], 'transgenic': [4161], '2–/–),': [4167], 'C3H/HeJ,': [4168], 'control': [4170], 'mice.': [4172], 'lack': [4175], 'functional': [4177], 'due': [4181], 'missense': [4184], 'point': [4185], 'mutation': [4186], 'substitution': [4191], 'histidine': [4193], 'proline': [4195], 'cytoplasmic': [4198, 4467], 'portion': [4199], '(43Poltorak': [4203], 'He': [4205], 'X.': [4206, 4215], 'Smirnova': [4207], 'Liu': [4209], 'M.Y.': [4210], 'Van': [4211], 'Huffel': [4212], 'Du': [4214], 'Birdwell': [4216], 'Alejos': [4218], 'Silva': [4220], 'Galanos': [4222], 'Freudenberg': [4224], 'Ricciardi-Castagnoli': [4226], 'Layton': [4228], 'Beutler': [4230], '1998;': [4233, 4491], '282:': [4234], '2085-2088Crossref': [4235], '(6578)': [4238], '44Qureshi': [4241], 'S.T.': [4242], 'Lariviere': [4243], 'Leveque': [4245], 'Clermont': [4247], 'Moore': [4249], 'Gros': [4251], 'Malo': [4253], '189:': [4259], '615-625Crossref': [4260], '(1365)': [4263], 'degree': [4280], '(Fig.': [4288, 4332, 4364], '1A).': [4289], 'strains,': [4293], 'maximal': [4294], 'content': [4315], 'altered': [4320], '1B).': [4333], 'Such': [4334, 4393], '–/–': [4362, 4372], '1C).': [4365], 'As': [4366], 'expected,': [4367], '2-specific': [4377], 'PGN': [4379], 'PAM': [4381], 'did': [4382], 'produce': [4384], 'alterations': [4386], 'concentrations': [4390], 'indicate': [4395], 'delineate': [4412], 'HMGB1-': [4432], 'LPS-stimulated': [4434], 'neutrophils.': [4435], 'catalytically': [4440], 'active': [4441], 'components': [4442], '(IKK)': [4447], 'complex': [4448], 'that,': [4449], 'activated': [4451], 'phosphorylate': [4460], 'members': [4461], 'family,': [4465], 'freeing': [4466], 'translocate': [4470], 'nucleus': [4473], 'initiate': [4475], 'transcriptional': [4476], "(45O'Connell": [4478], 'Bennett': [4480], 'B.L.': [4481], 'Mercurio': [4482], 'F.': [4483], 'Manning': [4484], 'Mackman': [4486], '273:': [4492], '30410-30414Abstract': [4493], '(164)': [4501], '46Fischer': [4504], 'Page': [4506], 'Weber': [4508], 'Eisele': [4510], 'Neumeier': [4512], 'Brand': [4514], '24625-24632Abstract': [4521], '(76)': [4529], '47Dunne,': [4532], 'A.,': [4533], "O'Neill,": [4535], '(2003)': [4538], "Science's": [4539], 'STKE': [4540], 'http://stke.sciencemag.org/cgi/reprint/sigtrans;2003/171/re3Google': [4541], 'dispensable': [4546], 'induced': [4550], 'mediators': [4552], 'deficient': [4561], 'show': [4564], 'impaired': [4565], 'IL-6': [4569], 'produ': [4570]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2061163173', 'counts_by_year': [{'year': 2024, 'cited_by_count': 20}, {'year': 2023, 'cited_by_count': 28}, {'year': 2022, 'cited_by_count': 38}, {'year': 2021, 'cited_by_count': 64}, {'year': 2020, 'cited_by_count': 62}, {'year': 2019, 'cited_by_count': 49}, {'year': 2018, 'cited_by_count': 79}, {'year': 2017, 'cited_by_count': 76}, {'year': 2016, 'cited_by_count': 95}, {'year': 2015, 'cited_by_count': 97}, {'year': 2014, 'cited_by_count': 93}, {'year': 2013, 'cited_by_count': 110}, {'year': 2012, 'cited_by_count': 106}], 'updated_date': '2024-12-22T14:24:01.358757', 'created_date': '2016-06-24'}
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