Publication Information

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{'volume': '21', 'issue': '4', 'first_page': '247', 'last_page': '253'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10351', 'display_name': 'Liver Disease Diagnosis and Treatment', 'score': 0.9998, 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[25], 'the': [26, 32, 41, 123, 146, 180, 194], 'underlying': [27], 'mechanism.': [28], 'Methods:': [29], 'Expression': [30], 'basolateral': [33], 'anion': [35, 196], 'transporting': [36], 'polypeptide': [37], 'OATP‐C': [38, 126, 163, 177], '(SLC21A6)': [39], 'and': [40, 65, 82, 96, 110, 145, 164, 189], 'canalicular': [42, 184], 'multidrug': [43], 'resistance': [44], 'protein': [45], '2': [46], '(MRP2)': [47], 'studied': [49], 'in': [50, 66, 128, 173], 'patients': [51, 132], 'with': [52, 73, 78, 84, 133], 'primary': [53], 'sclerosing': [54], 'cholangitis': [55], '(PSC)': [56], '(': [57, 69], 'n': [58, 70], '=4),': [59], 'a': [60], 'disease,': [64], 'non‐cholestatic': [67], 'controls': [68, 138, 154], '=4)': [71], '(two': [72], 'hepatitis': [75], 'C,': [76], 'one': [77, 83], 'idiopathic': [79], 'cirrhosis': [81], 'fatty': [85], 'liver).': [86], 'Total': [87], 'RNA': [88], 'isolated': [90], 'tissue,': [93], 'reverse': [94], 'transcribed': [95], 'subjected': [97], 'polymerase': [99], 'chain': [100], 'reaction': [101], '(PCR)': [102], 'amplification': [103], 'using': [104], 'primers': [105], 'specific': [106], 'for': [107, 120], 'OATP‐C,': [108], 'MRP2': [109, 149, 165], 'β‐actin.': [111], 'PCR': [112], 'products': [113], 'were': [114], 'quantified': [115], 'densitometrically.': [116], 'Results:': [117], 'When': [118], 'normalized': [119], 'β‐actin': [121], 'expression,': [122], 'level': [124, 147, 172], 'mRNA': [127, 150, 171], 'tissue': [130], 'PSC': [134], '49%': [136], '(OATP‐C/β‐actin': [139], '1.60±0.25': [140], 'vs.': [141, 157], '3.24±0.69;': [142], 'p': [143, 159], '<0.05)': [144], '27%': [152], '(MRP2/β‐actin': [155], '0.70±0.36': [156], '2.54±0.56;': [158], '<0.01).': [160], 'Conclusions:': [161], 'Both': [162], 'are': [166], 'decreased': [167], 'as': [168], 'measured': [169], 'by': [170], 'PSC.': [174], 'Downregulation': [175], 'might': [178], 'be': [179], 'consequence': [181], 'impaired': [183], 'secretion': [185], 'could': [190], 'serve': [191], 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