Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice

Name: Work Video:
Duration: 3 min 30 s
Susanna Kemppainen; Tomi Rantamäki; André Jerónimo-Santos; Gregoire Lavasseur; Henri Autio; Nina N. Karpova; Elisa Kärkkäinen; Saara Stavén; Hugo Vicente Miranda; Tiago F. Outeiro; Maria José Diógenes; Serge Laroche; Sabrina Davis; Ana M. Sebastião; Eero Ċastrén; Heikki Tanila
{'id': 'https://openalex.org/W2061117696', 'doi': 'https://doi.org/10.1016/j.neurobiolaging.2011.11.006', 'title': 'Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice', 'display_name': 'Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice', 'publication_year': 2011, 'publication_date': '2011-12-31', 'ids': {'openalex': 'https://openalex.org/W2061117696', 'doi': 'https://doi.org/10.1016/j.neurobiolaging.2011.11.006', 'mag': '2061117696', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22209410'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.neurobiolaging.2011.11.006', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S284573', 'display_name': 'Neurobiology of Aging', 'issn_l': '0197-4580', 'issn': ['0197-4580', '1558-1497'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5018797225', 'display_name': 'Susanna Kemppainen', 'orcid': 'https://orcid.org/0000-0001-5372-1918'}, 'institutions': [{'id': 'https://openalex.org/I175532246', 'display_name': 'University of Eastern Finland', 'ror': 'https://ror.org/00cyydd11', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I175532246']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Susanna Kemppainen', 'raw_affiliation_strings': ['A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland'], 'affiliations': [{'raw_affiliation_string': 'A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland', 'institution_ids': ['https://openalex.org/I175532246']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040169342', 'display_name': 'Tomi Rantamäki', 'orcid': 'https://orcid.org/0000-0002-0052-1434'}, 'institutions': [{'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I133731052']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Tomi Rantamäki', 'raw_affiliation_strings': ['Neuroscience Center, University of Helsinki, Helsinki, Finland'], 'affiliations': [{'raw_affiliation_string': 'Neuroscience Center, University of Helsinki, Helsinki, Finland', 'institution_ids': ['https://openalex.org/I133731052']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068561697', 'display_name': 'André Jerónimo-Santos', 'orcid': 'https://orcid.org/0000-0002-9599-6597'}, 'institutions': [{'id': 'https://openalex.org/I141596103', 'display_name': 'University of Lisbon', 'ror': 'https://ror.org/01c27hj86', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I141596103']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'André Jerónimo-Santos', 'raw_affiliation_strings': ['Institute of Pharmacology and Neurosciences, Faculty of Medicine and Unit of Neurosciences, Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal'], 'affiliations': [{'raw_affiliation_string': 'Institute of Pharmacology and Neurosciences, Faculty of Medicine and Unit of Neurosciences, Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal', 'institution_ids': ['https://openalex.org/I141596103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105855782', 'display_name': 'Gregoire Lavasseur', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I102197404', 'display_name': 'Université Paris-Sud', 'ror': 'https://ror.org/028rypz17', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I102197404']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Gregoire Lavasseur', 'raw_affiliation_strings': ['CNRS, UMR 8195, Orsay, France', 'Univ Paris-Sud, Centre de Neurosciences Paris-Sud, UMR 8195, Orsay, France'], 'affiliations': [{'raw_affiliation_string': 'CNRS, UMR 8195, Orsay, France', 'institution_ids': ['https://openalex.org/I1294671590']}, {'raw_affiliation_string': 'Univ Paris-Sud, Centre de Neurosciences Paris-Sud, UMR 8195, Orsay, France', 'institution_ids': ['https://openalex.org/I102197404']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040160463', 'display_name': 'Henri Autio', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I133731052']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Henri Autio', 'raw_affiliation_strings': ['Neuroscience Center, University of Helsinki, Helsinki, Finland'], 'affiliations': [{'raw_affiliation_string': 'Neuroscience Center, University of Helsinki, Helsinki, Finland', 'institution_ids': ['https://openalex.org/I133731052']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052940659', 'display_name': 'Nina N. Karpova', 'orcid': 'https://orcid.org/0000-0002-3197-4559'}, 'institutions': [{'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I133731052']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Nina Karpova', 'raw_affiliation_strings': ['Neuroscience Center, University of Helsinki, Helsinki, Finland'], 'affiliations': [{'raw_affiliation_string': 'Neuroscience Center, University of Helsinki, Helsinki, Finland', 'institution_ids': ['https://openalex.org/I133731052']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110117925', 'display_name': 'Elisa Kärkkäinen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I175532246', 'display_name': 'University of Eastern Finland', 'ror': 'https://ror.org/00cyydd11', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I175532246']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Elisa Kärkkäinen', 'raw_affiliation_strings': ['A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland'], 'affiliations': [{'raw_affiliation_string': 'A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland', 'institution_ids': ['https://openalex.org/I175532246']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013993264', 'display_name': 'Saara Stavén', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I175532246', 'display_name': 'University of Eastern Finland', 'ror': 'https://ror.org/00cyydd11', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I175532246']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Saara Stavén', 'raw_affiliation_strings': ['A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland'], 'affiliations': [{'raw_affiliation_string': 'A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland', 'institution_ids': ['https://openalex.org/I175532246']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087439679', 'display_name': 'Hugo Vicente Miranda', 'orcid': 'https://orcid.org/0000-0001-8065-9259'}, 'institutions': [{'id': 'https://openalex.org/I4392738257', 'display_name': 'Instituto de Medicina Molecular João Lobo Antunes', 'ror': 'https://ror.org/019g8w217', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I141596103', 'https://openalex.org/I4392738257']}], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hugo Vicente Miranda', 'raw_affiliation_strings': ['Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisboa, Portugal'], 'affiliations': [{'raw_affiliation_string': 'Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisboa, Portugal', 'institution_ids': ['https://openalex.org/I4392738257']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014020587', 'display_name': 'Tiago F. Outeiro', 'orcid': 'https://orcid.org/0000-0003-1679-1727'}, 'institutions': [{'id': 'https://openalex.org/I4392738257', 'display_name': 'Instituto de Medicina Molecular João Lobo Antunes', 'ror': 'https://ror.org/019g8w217', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I141596103', 'https://openalex.org/I4392738257']}, {'id': 'https://openalex.org/I141596103', 'display_name': 'University of Lisbon', 'ror': 'https://ror.org/01c27hj86', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I141596103']}, {'id': 'https://openalex.org/I4210116730', 'display_name': 'Universitätsmedizin Göttingen', 'ror': 'https://ror.org/021ft0n22', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210116730']}], 'countries': ['DE', 'PT'], 'is_corresponding': False, 'raw_author_name': 'Tiago F. Outeiro', 'raw_affiliation_strings': ['Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisboa, Portugal', 'Department of NeuroDegeneration and Restaurative Research, University Medizin Gottingen, Gottingen, Germany', 'Instituto de Fisiologia, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal'], 'affiliations': [{'raw_affiliation_string': 'Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisboa, Portugal', 'institution_ids': ['https://openalex.org/I4392738257']}, {'raw_affiliation_string': 'Instituto de Fisiologia, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal', 'institution_ids': ['https://openalex.org/I141596103']}, {'raw_affiliation_string': 'Department of NeuroDegeneration and Restaurative Research, University Medizin Gottingen, Gottingen, Germany', 'institution_ids': ['https://openalex.org/I4210116730']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027130760', 'display_name': 'Maria José Diógenes', 'orcid': 'https://orcid.org/0000-0001-5486-6246'}, 'institutions': [{'id': 'https://openalex.org/I141596103', 'display_name': 'University of Lisbon', 'ror': 'https://ror.org/01c27hj86', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I141596103']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Maria J. Diógenes', 'raw_affiliation_strings': ['Institute of Pharmacology and Neurosciences, Faculty of Medicine and Unit of Neurosciences, Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal'], 'affiliations': [{'raw_affiliation_string': 'Institute of Pharmacology and Neurosciences, Faculty of Medicine and Unit of Neurosciences, Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal', 'institution_ids': ['https://openalex.org/I141596103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023828819', 'display_name': 'Serge Laroche', 'orcid': 'https://orcid.org/0000-0002-2601-385X'}, 'institutions': [{'id': 'https://openalex.org/I102197404', 'display_name': 'Université Paris-Sud', 'ror': 'https://ror.org/028rypz17', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I102197404']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Serge Laroche', 'raw_affiliation_strings': ['CNRS, UMR 8195, Orsay, France', 'Univ Paris-Sud, Centre de Neurosciences Paris-Sud, UMR 8195, Orsay, France'], 'affiliations': [{'raw_affiliation_string': 'Univ Paris-Sud, Centre de Neurosciences Paris-Sud, UMR 8195, Orsay, France', 'institution_ids': ['https://openalex.org/I102197404']}, {'raw_affiliation_string': 'CNRS, UMR 8195, Orsay, France', 'institution_ids': ['https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105835140', 'display_name': 'Sabrina Davis', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I102197404', 'display_name': 'Université Paris-Sud', 'ror': 'https://ror.org/028rypz17', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I102197404']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Sabrina Davis', 'raw_affiliation_strings': ['CNRS, UMR 8195, Orsay, France', 'Univ Paris-Sud, Centre de Neurosciences Paris-Sud, UMR 8195, Orsay, France'], 'affiliations': [{'raw_affiliation_string': 'Univ Paris-Sud, Centre de Neurosciences Paris-Sud, UMR 8195, Orsay, France', 'institution_ids': ['https://openalex.org/I102197404']}, {'raw_affiliation_string': 'CNRS, UMR 8195, Orsay, France', 'institution_ids': ['https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021255614', 'display_name': 'Ana M. Sebastião', 'orcid': 'https://orcid.org/0000-0001-9030-6115'}, 'institutions': [{'id': 'https://openalex.org/I141596103', 'display_name': 'University of Lisbon', 'ror': 'https://ror.org/01c27hj86', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I141596103']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Ana M. Sebastião', 'raw_affiliation_strings': ['Institute of Pharmacology and Neurosciences, Faculty of Medicine and Unit of Neurosciences, Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal'], 'affiliations': [{'raw_affiliation_string': 'Institute of Pharmacology and Neurosciences, Faculty of Medicine and Unit of Neurosciences, Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal', 'institution_ids': ['https://openalex.org/I141596103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019744869', 'display_name': 'Eero Ċastrén', 'orcid': 'https://orcid.org/0000-0002-1402-2791'}, 'institutions': [{'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I133731052']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Eero Castrén', 'raw_affiliation_strings': ['Neuroscience Center, University of Helsinki, Helsinki, Finland'], 'affiliations': [{'raw_affiliation_string': 'Neuroscience Center, University of Helsinki, Helsinki, Finland', 'institution_ids': ['https://openalex.org/I133731052']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5005270668', 'display_name': 'Heikki Tanila', 'orcid': 'https://orcid.org/0000-0001-8579-7562'}, 'institutions': [{'id': 'https://openalex.org/I175532246', 'display_name': 'University of Eastern Finland', 'ror': 'https://ror.org/00cyydd11', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I175532246']}, {'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I133731052']}, {'id': 'https://openalex.org/I4210092991', 'display_name': 'Kuopio University Hospital', 'ror': 'https://ror.org/00fqdfs68', 'country_code': 'FI', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210092991']}], 'countries': ['FI'], 'is_corresponding': True, 'raw_author_name': 'Heikki Tanila', 'raw_affiliation_strings': ['A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland', 'Department of Neurology, Kuopio University Hospital, Kuopio, Finland', 'Neuroscience Center, University of Helsinki, Helsinki, Finland'], 'affiliations': [{'raw_affiliation_string': 'A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland', 'institution_ids': ['https://openalex.org/I175532246']}, {'raw_affiliation_string': 'Neuroscience Center, University of Helsinki, Helsinki, Finland', 'institution_ids': ['https://openalex.org/I133731052']}, {'raw_affiliation_string': 'Department of Neurology, Kuopio University Hospital, Kuopio, Finland', 'institution_ids': ['https://openalex.org/I4210092991']}]}], 'institution_assertions': [], 'countries_distinct_count': 4, 'institutions_distinct_count': 8, 'corresponding_author_ids': ['https://openalex.org/A5005270668'], 'corresponding_institution_ids': ['https://openalex.org/I175532246', 'https://openalex.org/I133731052', 'https://openalex.org/I4210092991'], 'apc_list': {'value': 3200, 'currency': 'USD', 'value_usd': 3200, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.681, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 84, 'citation_normalized_percentile': {'value': 0.877676, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '33', 'issue': '6', 'first_page': '1122.e23', 'last_page': '1122.e39'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10483', 'display_name': 'Nerve injury and regeneration', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10483', 'display_name': 'Nerve injury and regeneration', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10608', 'display_name': 'Neurogenesis and neuroplasticity mechanisms', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C97124661', 'wikidata': 'https://www.wikidata.org/wiki/Q14897782', 'display_name': 'Tropomyosin receptor kinase B', 'level': 4, 'score': 0.9922382}, {'id': 'https://openalex.org/C160539049', 'wikidata': 'https://www.wikidata.org/wiki/Q3064187', 'display_name': 'Neurotrophic factors', 'level': 3, 'score': 0.580526}, {'id': 'https://openalex.org/C2778790584', 'wikidata': 'https://www.wikidata.org/wiki/Q123045', 'display_name': 'Brain-derived neurotrophic factor', 'level': 4, 'score': 0.5305187}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.48515493}, {'id': 'https://openalex.org/C53345823', 'wikidata': 'https://www.wikidata.org/wiki/Q5531554', 'display_name': 'Gene isoform', 'level': 3, 'score': 0.46503943}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.4453135}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.42443576}, {'id': 'https://openalex.org/C92020748', 'wikidata': 'https://www.wikidata.org/wiki/Q420457', 'display_name': 'Neurotrophin', 'level': 3, 'score': 0.41776967}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.38561934}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.38502485}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3397168}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.23857513}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.080248415}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.04393804}], 'mesh': [{'descriptor_ui': 'D016564', 'descriptor_name': 'Amyloid beta-Protein Precursor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D008569', 'descriptor_name': 'Memory Disorders', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D053764', 'descriptor_name': 'Presenilin-1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D020813', 'descriptor_name': 'Receptor, trkB', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D016564', 'descriptor_name': 'Amyloid beta-Protein Precursor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016564', 'descriptor_name': 'Amyloid beta-Protein Precursor', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008569', 'descriptor_name': 'Memory Disorders', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008569', 'descriptor_name': 'Memory Disorders', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008569', 'descriptor_name': 'Memory Disorders', 'qualifier_ui': 'Q000523', 'qualifier_name': 'psychology', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008811', 'descriptor_name': 'Mice, Inbred DBA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053764', 'descriptor_name': 'Presenilin-1', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D053764', 'descriptor_name': 'Presenilin-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020813', 'descriptor_name': 'Receptor, trkB', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D020813', 'descriptor_name': 'Receptor, trkB', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020813', 'descriptor_name': 'Receptor, trkB', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.neurobiolaging.2011.11.006', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S284573', 'display_name': 'Neurobiology of Aging', 'issn_l': '0197-4580', 'issn': ['0197-4580', '1558-1497'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://hal.archives-ouvertes.fr/hal-00718987', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://hal.science/hal-00718987', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22209410', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 54, 'referenced_works': ['https://openalex.org/W1512339474', 'https://openalex.org/W1966507933', 'https://openalex.org/W1968973248', 'https://openalex.org/W1971335269', 'https://openalex.org/W1980708963', 'https://openalex.org/W1988524644', 'https://openalex.org/W1994431913', 'https://openalex.org/W1996893328', 'https://openalex.org/W2000967843', 'https://openalex.org/W2001210466', 'https://openalex.org/W2003665687', 'https://openalex.org/W2004305267', 'https://openalex.org/W2005719973', 'https://openalex.org/W2006376420', 'https://openalex.org/W2007282621', 'https://openalex.org/W2009950151', 'https://openalex.org/W2021497853', 'https://openalex.org/W2027206459', 'https://openalex.org/W2036738726', 'https://openalex.org/W2038572225', 'https://openalex.org/W2042794149', 'https://openalex.org/W2043015557', 'https://openalex.org/W2055979394', 'https://openalex.org/W2056716542', 'https://openalex.org/W2057709942', 'https://openalex.org/W2060446687', 'https://openalex.org/W2062214806', 'https://openalex.org/W2064468814', 'https://openalex.org/W2065843361', 'https://openalex.org/W2066110504', 'https://openalex.org/W2069312841', 'https://openalex.org/W2069462123', 'https://openalex.org/W2071610467', 'https://openalex.org/W2075348467', 'https://openalex.org/W2075481535', 'https://openalex.org/W2076246785', 'https://openalex.org/W2076531205', 'https://openalex.org/W2077208218', 'https://openalex.org/W2082044837', 'https://openalex.org/W2086135754', 'https://openalex.org/W2086244307', 'https://openalex.org/W2088291608', 'https://openalex.org/W2088937091', 'https://openalex.org/W2121075882', 'https://openalex.org/W2126869810', 'https://openalex.org/W2127027544', 'https://openalex.org/W2139565721', 'https://openalex.org/W2142943752', 'https://openalex.org/W2151986987', 'https://openalex.org/W2152304945', 'https://openalex.org/W2157001082', 'https://openalex.org/W2165064374', 'https://openalex.org/W2168334242', 'https://openalex.org/W2168950597'], 'related_works': ['https://openalex.org/W56018094', 'https://openalex.org/W4255543363', 'https://openalex.org/W3021434253', 'https://openalex.org/W2154977175', 'https://openalex.org/W2130489472', 'https://openalex.org/W2087696642', 'https://openalex.org/W2072353392', 'https://openalex.org/W2066790769', 'https://openalex.org/W2014363182', 'https://openalex.org/W2007837302'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2061117696', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-15T10:23:08.034362', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
