Title: Lyophilization and rehydration of liposomes
Abstract: Many studies have been undertaken with the aim of proving the potentiality of liposomes and vesicles as drug carriers. However, the results obtained have not yet been developed industrially. One of the reasons for this is the lack of a satisfactory liposome and vesicle preservation method. This study deals with the behaviour of liposomes during lyophilization processes, either in the presence or in the absence of sodium ioxitalamate and maltose. The bilayers are constiluted either by dipalmitoylphosphatidylcholine (DPPC) alone or as a mixture with cholesterol (7/2). The liposome are characterized by their size, their microscopic structure and by release of the active agent. To complete the pharmaceutical study, differential scanning calorimetry (DSC) has been used to analyse the evolution of liposome hydration.
Publication Year: 1985
Publication Date: 1985-06-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 13
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