Publication Information

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'https://openalex.org/W2013534902', 'https://openalex.org/W2022337107', 'https://openalex.org/W2031117986', 'https://openalex.org/W2038087154', 'https://openalex.org/W2048157659', 'https://openalex.org/W2054240817', 'https://openalex.org/W2055622790', 'https://openalex.org/W2057701166', 'https://openalex.org/W2058334508', 'https://openalex.org/W2058795973', 'https://openalex.org/W2060401618', 'https://openalex.org/W2063234204', 'https://openalex.org/W2063934456', 'https://openalex.org/W2066525632', 'https://openalex.org/W2066840018', 'https://openalex.org/W2069119711', 'https://openalex.org/W2073487012', 'https://openalex.org/W2074893112', 'https://openalex.org/W2078901242', 'https://openalex.org/W2088311074', 'https://openalex.org/W2090780673', 'https://openalex.org/W2092398899', 'https://openalex.org/W2093092469', 'https://openalex.org/W2095361649', 'https://openalex.org/W2104163119', 'https://openalex.org/W2114882367', 'https://openalex.org/W2132935598', 'https://openalex.org/W2145310996', 'https://openalex.org/W2151327193', 'https://openalex.org/W2172249877', 'https://openalex.org/W2462124667', 'https://openalex.org/W4254455346', 'https://openalex.org/W5338072', 'https://openalex.org/W74101389', 'https://openalex.org/W82031178'], 'related_works': ['https://openalex.org/W80153860', 'https://openalex.org/W2463544644', 'https://openalex.org/W2407681830', 'https://openalex.org/W2366582484', 'https://openalex.org/W2171244081', 'https://openalex.org/W2169661517', 'https://openalex.org/W2116307528', 'https://openalex.org/W2112369097', 'https://openalex.org/W2107684873', 'https://openalex.org/W2088585338'], 'abstract_inverted_index': {'The': [0, 123, 193, 316, 697, 2130, 2317, 2370, 2480, 2522, 2768, 2779, 2945, 3074, 3263, 3277, 3372, 3435, 3488, 3514, 3535, 3711, 3829, 3894, 4163, 4226, 4621], 'membrane': [1, 194, 429, 664], 'pore': [2, 195], 'proteins,': [3, 196, 434, 1072, 4321], 'aquaporins': [4, 197], '(AQPs),': [5, 198, 437], 'facilitate': [6, 199], 'the': [7, 22, 34, 45, 48, 73, 93, 163, 200, 215, 227, 238, 241, 266, 286, 356, 404, 416, 566, 588, 663, 880, 1080, 1245, 1303, 1308, 1333, 1355, 1359, 1370, 1373, 1435, 1612, 1617, 1672, 1784, 1814, 1821, 1871, 1874, 1889, 1898, 1907, 1912, 1966, 1999, 2012, 2023, 2027, 2036, 2114, 2231, 2236, 2241, 2246, 2274, 2314, 2477, 2489, 2494, 2531, 2536, 2788, 2813, 2909, 2961, 3160, 3229, 3241, 3281, 3293, 3300, 3312, 3321, 3340, 3353, 3360, 3368, 3385, 3396, 3432, 3494, 3501, 3532, 3553, 3561, 3584, 3591, 3599, 3606, 3613, 3658, 3705, 3734, 3739, 3815, 3826, 3882, 3901, 3904, 3925, 3928, 3930, 3935, 3953, 3957, 3982, 3994, 4001, 4059, 4070, 4178, 4196, 4201, 4273, 4307, 4313, 4445, 4449, 4533, 4547, 4559, 4573, 4611], 'osmotically': [8, 201, 1052], 'driven': [9, 202], 'passage': [10, 203], 'of': [11, 24, 36, 50, 75, 86, 125, 165, 183, 204, 217, 229, 243, 268, 279, 318, 358, 376, 407, 412, 428, 699, 882, 1023, 1040, 1043, 1076, 1082, 1117, 1233, 1247, 1305, 1310, 1320, 1332, 1354, 1358, 1372, 1437, 1611, 1620, 1856, 1876, 1891, 1900, 1968, 1998, 2015, 2018, 2029, 2042, 2134, 2208, 2218, 2225, 2240, 2266, 2291, 2488, 2530, 2565, 2590, 2692, 2710, 2840, 2852, 2898, 2904, 2917, 2970, 2993, 3014, 3228, 3232, 3240, 3272, 3280, 3296, 3315, 3375, 3439, 3449, 3473, 3479, 3500, 3583, 3612, 3657, 3664, 3669, 3678, 3693, 3713, 3725, 3745, 3751, 3790, 3825, 3845, 3849, 3853, 3857, 3861, 3864, 3869, 3878, 3903, 3927, 3956, 4100, 4240, 4254, 4294, 4309, 4315, 4371, 4448, 4452, 4469, 4482, 4497, 4519, 4539, 4579, 4588, 4624], 'water': [12, 184, 205, 377, 408, 668, 1322], 'and,': [13, 206], 'in': [14, 79, 92, 112, 119, 129, 146, 170, 207, 272, 285, 305, 312, 322, 339, 363, 415, 483, 565, 587, 662, 1028, 1074, 1149, 1153, 1307, 1344, 1368, 1609, 1616, 1671, 1778, 1820, 1914, 1917, 1974, 1979, 2003, 2085, 2120, 2158, 2162, 2263, 2726, 2783, 2793, 2849, 2914, 3061, 3152, 3193, 3339, 3352, 3469, 3552, 3588, 3626, 3641, 3651, 3698, 3722, 3727, 3998, 4026, 4035, 4043, 4083, 4096, 4144, 4209, 4298, 4325, 4600], 'some': [15, 25, 29, 139, 208, 218, 222, 332, 700, 1242], 'instances,': [16, 209], 'small': [17, 210], 'solutes.': [18, 211], 'Under': [19, 212], 'hyperosmotic': [20, 56, 67, 173, 213, 249, 260, 366, 877, 1252, 1315, 1892, 1984, 3873, 4310, 4340, 4461, 4586, 4601], 'conditions,': [21, 214], 'expression': [23, 35, 49, 74, 111, 124, 216, 228, 242, 267, 304, 317, 698, 881, 1246, 1309, 1436, 1875, 1899, 1967, 2028, 4314, 4623], 'AQPs': [26, 115, 166, 219, 308, 359, 553, 570, 648, 701, 883, 1234, 1361, 1877, 2987], 'changes,': [27, 220], 'and': [28, 38, 52, 77, 83, 90, 106, 127, 138, 167, 186, 221, 231, 245, 270, 276, 283, 299, 320, 331, 360, 379, 421, 492, 557, 581, 584, 665, 760, 835, 887, 1046, 1071, 1079, 1085, 1137, 1249, 1312, 1324, 1571, 1604, 1669, 1737, 1878, 1902, 1904, 1920, 1970, 1978, 1996, 2020, 2022, 2031, 2079, 2118, 2154, 2165, 2230, 2320, 2325, 2406, 2437, 2466, 2493, 2515, 2535, 2557, 2581, 2763, 2772, 2787, 2797, 2820, 2826, 2842, 2871, 2875, 2906, 2935, 2960, 2965, 2983, 2988, 3018, 3024, 3029, 3042, 3182, 3235, 3275, 3299, 3325, 3346, 3423, 3460, 3466, 3505, 3521, 3567, 3577, 3649, 3661, 3709, 3717, 3742, 3777, 3819, 3900, 3916, 3938, 3960, 3975, 4038, 4040, 4051, 4111, 4184, 4221, 4272, 4296, 4317, 4320, 4383, 4388, 4393, 4402, 4406, 4409, 4429, 4432, 4454, 4479, 4486, 4494, 4512, 4526, 4561, 4590], 'studies': [30, 140, 223, 333, 1432, 3730], 'have': [31, 141, 224, 334, 573, 666, 1049, 1365, 1738, 2327, 2596], 'shown': [32, 142, 225, 335], 'that': [33, 66, 143, 226, 259, 336, 657, 1034, 1048, 1146, 1244, 1434, 1965, 1990, 2026, 4552], 'AQP1': [37, 230, 1248, 1438], 'AQP5': [39, 232, 1250], 'is': [40, 148, 155, 233, 341, 348, 401, 655, 702, 1254, 1317, 1327, 1338, 1598, 1780, 1867, 1972, 2033, 3266, 4555], 'regulated': [41, 234, 1255, 2034, 3267, 4556], 'by': [42, 55, 70, 235, 248, 263, 397, 704, 1238, 1256, 1983, 2035, 2140, 2245, 2294, 2473, 2571, 2583, 2803, 3034, 3215, 3268, 3391, 3446, 3738, 3817, 3887, 3981, 4000, 4206, 4250, 4277, 4629], 'MAPKs.': [43, 236, 1239], 'However,': [44, 237], 'mechanisms': [46, 239, 1033], 'regulating': [47, 240, 1911], 'AQP4': [51, 76, 89, 126, 244, 269, 282, 319, 1311, 1487, 1608, 1777, 1901, 1919, 1969, 2019, 2030, 2153, 2376, 2484, 2841, 3017, 3234, 3243, 3264, 3576, 4295, 4316, 4382, 4405, 4410, 4428, 4453, 4471, 4511, 4529, 4543, 4589], 'AQP9': [53, 78, 91, 128, 246, 271, 284, 321, 1313, 1572, 1818, 1903, 1921, 1971, 2021, 2032, 2155, 2409, 2526, 2843, 3236, 3376, 3554, 3578, 4297, 4318, 4384, 4407, 4420, 4430, 4455, 4487, 4513, 4564, 4591], 'induced': [54, 69, 175, 247, 262, 368, 1745, 1880, 1894, 1973, 4435, 4628], 'stress': [57, 68, 250, 261, 414, 878, 1067, 1316, 1893, 4311], 'are': [58, 251, 481, 554, 649, 1140, 1147, 1241, 1858, 1922, 2156, 4234], 'poorly': [59, 252], 'understood.': [60, 253], 'In': [61, 97, 254, 290, 875, 1813, 1986, 2150], 'this': [62, 255, 1991, 2009, 4553], 'study,': [63, 256], 'we': [64, 257, 1988], 'observed': [65, 258], 'mannitol': [71, 87, 154, 177, 264, 280, 347, 370, 1857, 1896, 2226, 3697, 3874, 3879, 4361, 4465, 4522, 4605, 4630], 'increased': [72, 88, 265, 281, 1670, 4395, 4412, 4473, 4489, 4515, 4622], 'cultured': [80, 113, 273, 306, 1975, 2004, 2084, 2811], 'rat': [81, 94, 274, 287, 1915, 1976, 1980, 2005, 2048], 'astrocytes,': [82, 275], 'intraperitoneal': [84, 277, 3888], 'infusion': [85, 278, 3784, 3889, 3892, 3895, 3905, 3936], 'brain': [95, 121, 133, 160, 191, 288, 314, 326, 353, 384, 1325, 1374, 1601, 1613, 1621, 1746, 1815, 1863, 1981, 3958, 3995], 'cortex.': [96, 289], 'addition,': [98, 291, 876, 1987], 'a': [99, 181, 187, 292, 374, 380, 426, 1366, 1739, 2503, 2509, 2516, 2545, 2551, 2558, 2698, 2708, 2727, 3005, 3045, 3392, 3401, 3470, 3480, 3506, 3642, 3780, 3788, 3791, 3837, 3872, 4097, 4188, 4437], 'p38': [100, 144, 168, 293, 337, 361, 1138, 2000, 2037, 3106], 'MAPK': [101, 145, 169, 294, 338, 362, 2001, 2038, 3095, 3107], 'inhibitor,': [102, 295, 4614], 'but': [103, 296, 653, 1302, 2160, 3918, 4570], 'not': [104, 297, 2161, 3920], 'ERK': [105, 298, 3123], 'JNK': [107, 300, 3138], 'inhibitors,': [108, 301], 'suppressed': [109, 302], 'their': [110, 303, 582], 'astrocytes.': [114, 307, 2006], 'play': [116, 309], 'important': [117, 310, 1115, 1141, 1868], 'roles': [118, 311], 'maintaining': [120, 313, 1369], 'homeostasis.': [122, 315], 'astrocytes': [130, 147, 171, 323, 340, 364, 1610, 1779, 1916, 1977, 2044, 2137, 2159, 3625, 3706, 4322, 4457, 4598], 'changes': [131, 324, 1027, 1152], 'after': [132, 325, 1825, 3689, 3733, 4112, 4397, 4414, 4423, 4475, 4491, 4516, 4536, 4576], 'ischemia': [134, 327], 'or': [135, 328, 2221, 3145, 3184, 3695, 3871, 3909, 4138, 4339, 4359, 4376, 4609], 'traumatic': [136, 329], 'injury,': [137, 330, 1602], 'activated': [149, 342, 1148], 'under': [150, 172, 343, 365, 410, 1251, 1314, 2812, 3610, 3779, 3836], 'similar': [151, 344, 3393], 'conditions.': [152, 345], 'Since': [153, 346], 'commonly': [156, 349, 1860], 'used': [157, 350, 440, 1859, 3760], 'to': [158, 180, 351, 373, 422, 572, 1026, 1037, 1109, 1120, 1151, 1341, 1364, 1600, 1861, 1869, 1887, 1905, 2053, 2313, 2697, 3044, 3287, 3292, 3306, 3311, 3334, 3337, 3350, 3359, 3379, 3384, 3431, 3486, 3512, 3539, 3547, 3550, 3560, 3822, 3834, 3881, 4088, 4107, 4114, 4303, 4436, 4508, 4532, 4572], 'reduce': [159, 352, 1862], 'edema,': [161, 354, 1864], 'understanding': [162, 355], 'regulation': [164, 357, 406, 2017], 'conditions': [174, 367, 411, 1253, 2815], 'with': [176, 369, 577, 1031, 1783, 1881, 1895, 2103, 2143, 2220, 2303, 2309, 2735, 2758, 2818, 2895, 2967, 2990, 3057, 3079, 3168, 3176, 3418, 3476, 3493, 3597, 3629, 3654, 3765, 4053, 4072, 4078, 4127, 4156, 4169, 4177, 4187, 4198, 4230, 4257, 4285, 4343, 4399, 4416, 4425, 4440, 4460, 4484, 4521, 4541, 4581, 4608], 'may': [178, 371, 562, 1068, 1112, 1349], 'lead': [179, 372], 'control': [182, 375, 3611, 3714, 4327], 'movements': [185, 378], 'new': [188, 381], 'treatment': [189, 382, 4398, 4415, 4424, 4483, 4498, 4520, 4540, 4580], 'for': [190, 383, 403, 1329, 2111, 2235, 2322, 2483, 2499, 2525, 2541, 2713, 2723, 2828, 2883, 2892, 2942, 2950, 2974, 2986, 2997, 3016, 3022, 3027, 3054, 3164, 3173, 3442, 3452, 3457, 3463, 3646, 3942, 3968, 4031, 4085, 4104, 4124, 4173, 4191, 4260, 4281, 4366, 4374, 4378, 4466, 4618], 'edema.': [192, 385], 'Water': [386], 'passes': [387], 'across': [388], 'cell': [389, 1044, 1077, 1110, 2131, 2845, 2910, 2946, 2979], 'membranes': [390, 3075, 3161], 'substantially': [391], 'faster': [392], 'than': [393, 559, 1748], 'can': [394], 'be': [395, 563, 1113, 1236], 'explained': [396], 'simple': [398], 'diffusion.': [399], 'This': [400, 1883], 'necessary': [402], 'active': [405], 'homeostasis': [409, 1039, 1371], 'osmotic': [413, 1029, 1121, 2016, 3977, 4330], 'kidneys,': [417], 'lungs,': [418], 'brain,': [419], 'etc.,': [420], 'meet': [423], 'these': [424], 'needs,': [425], 'family': [427], 'channel': [430], 'proteins': [431, 4389, 4433, 4514], 'evolved.': [432], 'These': [433, 1105], 'termed': [435], '“aquaporins”': [436], '1The': [438], 'abbreviations': [439], 'are:': [441], 'AQP,': [442], 'aquaporin;': [443], 'MAPK,': [444, 1139], 'mitogen-activated': [445, 475], 'protein': [446, 476, 1124, 1134, 2147, 3001, 3007, 3015, 4411, 4421, 4544, 4565, 4596, 4612], 'kinase;': [447, 451, 455, 473], 'ERK,': [448], 'extracellular': [449], 'signal-regulated': [450, 478, 1129], 'JNK,': [452], 'c-Jun': [453, 1132], 'NH2-terminal': [454], 'GFAP,': [456, 2978, 3019], 'glial': [457], 'fibrillary': [458, 2145], 'acidic': [459, 2146], 'protein;': [460], 'l-DMEM,': [461], 'low': [462, 2092], 'glucose': [463, 2093], "Dulbecco's": [464, 2096], 'modified': [465, 2097], "Eagle's": [466, 2098], 'medium;': [467], 'RT,': [468], 'reverse': [469, 2299], 'transcriptase;': [470], 'TK,': [471], 'thymidine': [472], 'MEK,': [474], 'kinase/extracellular': [477], 'kinase': [479, 1130, 1135, 3601], 'kinase.': [480], 'found': [482, 1964], 'all': [484, 493, 3151, 4261], 'life': [485], 'forms,': [486], 'including': [487, 707], 'archaea,': [488], 'eubacteria,': [489], 'fungi,': [490], 'plants,': [491], 'animal': [494, 3729], 'phyla': [495], '(1Ishibashi': [496], 'K.': [497, 675, 679, 765, 767, 769, 783, 839, 843, 845, 853, 985, 1470, 1927, 1929, 1931, 1945, 2170, 2172, 2174, 2188, 2334, 2336, 2338, 2352, 2419, 2603, 2605, 2607, 2621, 2642, 2648, 2665, 2675, 4007], 'Kuwahara': [498, 2416], 'M.': [499, 515, 632, 714, 716, 720, 777, 781, 849, 851, 855, 946, 966, 1056, 1440, 1535, 1541, 1547, 1555, 1696, 1702, 1708, 1716, 1754, 1798, 1802, 1939, 1943, 2182, 2186, 2346, 2350, 2417, 2446, 2615, 2619, 2644, 2669, 4011], 'Sasaki': [500, 951, 2424], 'S.': [501, 744, 916, 948, 952, 968, 1189, 1396, 1514, 1649, 2394, 2413, 2415, 2425, 2448, 4009], 'Rev.': [502], 'Physiol.': [503, 751, 753, 955, 988, 990, 1477, 3801], 'Biochem.': [504, 542, 893, 934, 2426], 'Pharmacol.': [505], '2000;': [506, 605, 1008, 1269, 1563, 1724, 1769], '141:': [507], '1-32Crossref': [508], 'PubMed': [509, 529, 548, 608, 624, 643, 692, 738, 796, 830, 870, 900, 921, 975, 994, 1016, 1063, 1100, 1166, 1183, 1209, 1226, 1277, 1297, 1388, 1424, 1452, 1482, 1503, 1529, 1566, 1593, 1638, 1664, 1690, 1727, 1772, 1849, 1958, 2073, 2201, 2365, 2399, 2459, 2634, 2657, 2684, 3258], 'Google': [510, 532, 551, 611, 627, 646, 695, 741, 757, 799, 833, 873, 903, 924, 943, 959, 978, 995, 1019, 1064, 1103, 1169, 1186, 1212, 1229, 1280, 1300, 1391, 1406, 1427, 1455, 1485, 1506, 1532, 1569, 1596, 1641, 1667, 1693, 1730, 1775, 1811, 1852, 1961, 2076, 2204, 2368, 2402, 2433, 2462, 2637, 2660, 2687, 3261, 3805, 4020], 'Scholar,': [511, 533, 612, 628, 742, 904, 925, 944, 960, 979, 996, 1170, 1187, 1213, 1281, 1392, 1407, 1456, 1507, 1533, 1642, 1694, 2638, 2661], '2Agre': [512], 'P.': [513, 599, 636, 685, 818, 908, 1002, 1263, 1764, 2388], 'Bonhivers': [514], 'Borgnia': [516], 'M.J.': [517], 'J.': [518, 541, 601, 618, 637, 727, 750, 822, 954, 987, 1005, 1057, 1162, 1172, 1198, 1266, 1286, 1382, 1401, 1409, 1416, 1574, 1580, 1585, 1805, 1830, 1836, 1841, 3800, 4015], 'Biol.': [519, 544, 620, 728, 826, 1006, 1059, 1199, 1267, 1287, 2428], 'Chem.': [520, 729, 1007, 1200, 1268, 1288], '1998;': [521, 545, 827, 938, 1060, 3255], '273:': [522], '14659-14662Abstract': [523], 'Full': [524, 526, 733, 735, 1011, 1013, 1097, 1204, 1206, 1272, 1274, 1292, 1294], 'Text': [525, 527, 734, 736, 1012, 1014, 1098, 1205, 1207, 1273, 1275, 1293, 1295], 'PDF': [528, 737, 1015, 1099, 1208, 1276, 1296], 'Scopus': [530, 549, 609, 625, 644, 693, 739, 797, 831, 871, 901, 922, 941, 976, 1017, 1101, 1167, 1184, 1210, 1227, 1278, 1298, 1389, 1425, 1453, 1483, 1504, 1530, 1567, 1594, 1639, 1665, 1691, 1728, 1773, 1850, 1959, 2074, 2202, 2366, 2400, 2460, 2635, 2658, 2685, 3259], '(394)': [531], '3Connolly': [534], 'D.L.': [535], 'Shanahan': [536], 'C.M.': [537, 1460], 'Weissberg': [538], 'P.L.': [539], 'Int.': [540, 2429], 'Cell': [543, 752, 824, 989, 1806, 2040, 3565], '30:': [546], '169-177Crossref': [547], '(44)': [550], 'Scholar).': [552, 647, 696, 874, 1020, 1065, 1104, 1230, 1428, 1731, 1776, 1812, 1853, 1962, 2077, 2205, 2369, 2688, 3262, 3806, 4021], 'widely': [555], 'distributed,': [556], 'more': [558], 'one': [560], 'AQP': [561, 4505, 4626], 'present': [564], 'same': [567, 3495, 4548], 'cell.': [568], 'All': [569, 2256], 'seem': [571], 'six': [574], 'transmembrane': [575], 'domains': [576], 'five': [578], 'connecting': [579], 'loops': [580], 'amino': [583], 'carboxyl': [585], 'termini': [586], 'cytoplasm': [589], '(4Fu': [590], 'D.': [591, 630, 712, 1054, 1160, 1446, 1800, 2452], 'Libson': [592], 'A.': [593, 687, 722, 917, 1380, 1519, 1543, 1549, 1654, 1704, 1710, 1790, 2395], 'Miercke': [594], 'L.J.': [595], 'Weitzman': [596], 'C.': [597, 1489, 1578, 1624, 1676, 1834], 'Nollert': [598], 'Krucinski': [600], 'Stroud': [602], 'R.M.': [603], 'Science.': [604, 1179, 1222], '290:': [606], '481-486Crossref': [607], '(889)': [610], '5Park': [613], 'J.H.': [614], 'Saier': [615], 'Jr.,': [616], 'M.H.': [617], 'Membr.': [619], '1996;': [621, 754, 956, 1163], '153:': [622], '171-180Crossref': [623], '(262)': [626], '6Kozono': [629], 'Yasui': [631], 'King': [633, 813, 909, 1003, 1264], 'L.S.': [634, 814, 910, 1004, 1265], 'Agre': [635, 684, 817, 907, 1001, 1262, 2387], 'Clin.': [638], 'Invest.': [639], '2002;': [640, 730, 897, 1403, 1421, 1526, 1661, 2654], '109:': [641], '1395-1399Crossref': [642], '(226)': [645], 'synthesized': [650], 'as': [651, 660, 2138, 2374, 2476, 2985, 3247, 3618, 3947, 3987, 4236], 'monomers,': [652], 'there': [654], 'evidence': [656, 2025], 'they': [658, 3170, 4075, 4118], 'exist': [659], 'tetramers': [661], 'four': [667, 3162, 4243], 'pores': [669], '(7Walz': [670], 'T.': [671, 673, 771, 787, 857, 861, 981, 983, 1193, 1537, 1545, 1551, 1557, 1698, 1706, 1712, 1718, 1756, 1933, 1949, 2058, 2176, 2192, 2340, 2356, 2423, 2609, 2625, 2667], 'Hirai': [672], 'Murata': [674], 'Heymann': [676], 'J.B.': [677], 'Mitsuoka': [678], 'Fujiyoshi': [680], 'Y.': [681, 773, 785, 847, 859, 962, 964, 1195, 1497, 1632, 1684, 1935, 1947, 2178, 2190, 2342, 2354, 2611, 2623, 2671, 4005, 4013], 'Smith': [682], 'B.L.': [683], 'Engel': [686], 'Nature.': [688], '1997;': [689], '387:': [690], '624-627Crossref': [691], '(385)': [694], 'affected': [703], 'various': [705, 2223, 4467], 'factors,': [706], 'vasopressin': [708], '(8Hasler': [709], 'U.': [710, 915, 2393, 2442], 'Mordasini': [711], 'Bens': [713], 'Bianchi': [715], 'Cluzeaud': [717], 'F.': [718, 890, 950, 1283, 1411, 1760, 1794, 2421, 3251], 'Roussel': [719], 'Vandewalle': [721], 'Feraille': [723], 'E.': [724, 1197, 1539, 1553, 1700, 1714], 'Martin': [725], 'P.Y.': [726], '277:': [731], '10379-10386Abstract': [732], '(154)': [740], '9Hozawa': [743], 'Holtzman': [745], 'E.J.': [746], 'Ausiello': [747], 'D.A.': [748], 'Am.': [749, 821, 953, 986, 3799, 4014], '270:': [755, 1202], 'C695-C702Crossref': [756], 'Scholar),': [758, 800, 834, 1301, 1486, 1570, 2403, 2434, 2463], 'hypoxia': [759], 'reoxygenation': [761], '(10Yamamoto': [762, 1924, 2167, 2331, 2600], 'N.': [763, 779, 841, 1758, 1925, 1941, 2168, 2184, 2332, 2348, 2601, 2617, 2640, 2663], 'Yoneda': [764, 1926, 2169, 2333, 2602], 'Asai': [766, 842, 1928, 2171, 2335, 2604, 2647, 2674], 'Sobue': [768, 844, 1930, 2173, 2337, 2606, 2641, 2664], 'Tada': [770, 856, 1932, 2175, 2339, 2608], 'Fujita': [772, 776, 846, 848, 1934, 1938, 2177, 2181, 2341, 2345, 2610, 2614, 2643], 'Katsuya': [774, 1936, 2179, 2343, 2612, 2645, 2672], 'H.': [775, 1191, 1937, 2180, 2344, 2613, 2646, 2673], 'Aihara': [778, 1940, 2183, 2347, 2616], 'Mase': [780, 850, 1942, 2185, 2349, 2618], 'Yamada': [782, 852, 1944, 2187, 2351, 2620], 'Miura': [784, 858, 1946, 2189, 2353, 2622, 2670], 'Kato': [786, 860, 1548, 1709, 1948, 2191, 2355, 2624], 'Brain': [788, 791, 862, 865, 1347, 1558, 1561, 1719, 1722, 1950, 1953, 2193, 2196, 2357, 2360, 2626, 2629, 2649, 2652, 2676, 2679], 'Res.': [789, 792, 863, 866, 895, 936, 1448, 1559, 1562, 1720, 1723, 1951, 1954, 2194, 2197, 2358, 2361, 2455, 2627, 2630, 2650, 2653, 2677, 2680], 'Mol.': [790, 825, 864, 1560, 1721, 1952, 2195, 2359, 2427, 2628, 2651, 2678], '2001;': [793, 867, 918, 972, 991, 1385, 1479, 1500, 1590, 1635, 1687, 1808, 1846, 1955, 2198, 2362, 2631, 2681], '90:': [794, 1956, 2199, 2363, 2632], '26-38Crossref': [795, 1957, 2200, 2364, 2633], '(145)': [798, 1960, 2203, 2367, 2636], 'growth': [801], 'factors': [802], '(11Borok': [803], 'Z.': [804, 1215, 2450], 'Lubman': [805], 'R.L.': [806, 1468], 'Danto': [807], 'S.I.': [808], 'Zhang': [809], 'X.L.': [810], 'Zabski': [811], 'S.M.': [812], 'Lee': [815, 1173, 1469], 'D.M.': [816], 'Crandall': [819], 'E.D.': [820, 1158], 'Respir.': [823], '18:': [828], '554-561Crossref': [829], '(164)': [832], 'retinoic': [836], 'acid': [837], '(12Yoneda': [838], 'Yamamoto': [840], 'Nakanishi': [854], '89:': [868], '94-102Crossref': [869], '(45)': [872], 'increases': [879], '1,': [884, 3907, 4391, 4400, 4476], '2,': [885, 4524], '3,': [886, 3908, 4401, 4477, 4492], '5': [888, 2896, 2968, 2975, 2991, 2998, 3847], '(13Umenishi': [889], 'Schrier': [891, 1284], 'R.W.': [892, 1285], 'Biophys.': [894, 935, 970, 2068], 'Commun.': [896, 937], '292:': [898], '771-775Crossref': [899], '(43)': [902, 2659], '14Leitch': [905], 'V.': [906, 1000, 1261], 'Proc.': [911, 2389], 'Natl.': [912, 2390], 'Acad.': [913, 2391], 'Sci.': [914, 1807, 2392], '98:': [919], '2894-2898Crossref': [920], '(119)': [923], '15Jenq': [926], 'W.': [927, 931], 'Mathieson': [928], 'I.M.': [929], 'Ihara': [930], 'Ramirez': [932], 'G.': [933], '245:': [939], '4-9Crossref': [940], '(50)': [942], '16Furuno': [945], 'Uchida': [947, 2412], 'Marumo': [949, 2420], '271:': [957], 'F854-F860PubMed': [958], '17Sugiyama': [961], 'Ota': [963], 'Hara': [965], 'Inoue': [967], 'Biochim.': [969, 2067], 'Acta.': [971, 2069], '1522:': [973], '82-88Crossref': [974], '(105)': [977], '18Matsuzaki': [980], 'Suzuki': [982], 'Takata': [984], '281:': [992], 'C55-C63Crossref': [993], '19Hoffert': [997], 'J.D.': [998, 1174, 1259], 'Leitch': [999, 1260], '275:': [1009, 1270], '9070-9077Abstract': [1010, 1271], '(115)': [1018, 1279, 1531, 1666], 'Many': [1021], 'types': [1022], 'cells': [1024, 2082, 2115], 'respond': [1025], 'pressure': [1030, 2709, 3978, 4331], 'adaptive': [1032], 'allow': [1035], 'them': [1036, 4208], 're-establish': [1038], 'those': [1041], 'aspects': [1042], 'structure': [1045], 'function': [1047, 1078], 'been': [1050, 2328, 2597], 'disturbed': [1051], '(20Kultz': [1053], 'Burg': [1055], 'Exp.': [1058], '201:': [1061], '3015-3021Crossref': [1062], 'Osmotic': [1066], 'damage': [1069, 1111], 'DNA': [1070, 2740, 3404, 3416], 'resulting': [1073], 'impairment': [1075], 'induction': [1081, 1992, 4451, 4587], 'repair': [1083], 'processes': [1084], 'protection': [1086], 'systems': [1087], '(21Schwartz': [1088], 'L.M.': [1089], 'Osborne': [1090], 'B.A.': [1091], 'Immunol.': [1092], 'Today.': [1093], '1993;': [1094, 3802], '14:': [1095], '582-590Abstract': [1096], '(68)': [1102], 'relatively': [1106], 'nonspecific': [1107, 4109], 'responses': [1108], 'an': [1114, 2264, 2754, 3204, 3619, 3891], 'aspect': [1116], 'cellular': [1118], 'adaptation': [1119], 'stress.': [1122, 1985], 'Mitogen-activated': [1123], 'kinases': [1125], '(MAPKs),': [1126], 'specifically': [1127], 'extra-cellular': [1128], '(ERK),': [1131], 'N-terminal': [1133], '(JNK),': [1136], 'intracellular': [1142], 'signal': [1143, 1908], 'transduction': [1144, 1909], 'pathways': [1145, 1910], 'response': [1150, 1913], 'osmolality': [1154], '(22Burg': [1155], 'M.B.': [1156], 'Kwon': [1157], 'Kultz': [1159], 'FASEB': [1161], '10:': [1164], '1598-1606Crossref': [1165], '(159)': [1168], '23Han': [1171], 'Bibbs': [1175], 'L.': [1176, 1415, 1576, 1584, 1804, 1832, 1840], 'Ulevitch': [1177], 'R.J.': [1178, 1221], '1994;': [1180, 1223, 2396], '265:': [1181, 1224], '808-811Crossref': [1182], '(2420)': [1185], '24Matsuda': [1188], 'Kawasaki': [1190], 'Moriguchi': [1192], 'Gotoh': [1194], 'Nishida': [1196], '1995;': [1201], '12781-12786Abstract': [1203], '(149)': [1211], '25Galcheva-Gargova': [1214], 'Derijard': [1216], 'B.': [1217, 1444, 1788], 'Wu': [1218], 'I.H.': [1219], 'Davis': [1220], '806-808Crossref': [1225], '(531)': [1228], 'Thus,': [1231], 'osmoregulation': [1232], 'might': [1235], 'mediated': [1237], 'There': [1240], 'reports': [1243], 'MAPKs': [1257, 1306, 2905, 3028, 3031], '(19Hoffert': [1258], '26Umenishi': [1282], '2003;': [1289], '278:': [1290], '15765-15770Abstract': [1291], '(155)': [1299], 'role': [1304, 1367], 'unclear.': [1318], 'Regulation': [1319], 'tissue': [1321], 'content': [1323], 'volume': [1326, 3472], 'critical': [1328], 'normal': [1330], 'functioning': [1331], 'central': [1334], 'nervous': [1335], 'system,': [1336], 'which': [1337, 1918, 3050, 3411, 3598], 'highly': [1339], 'sensitive': [1340, 1599], 'any': [1342, 3922], 'increase': [1343], 'intracranial': [1345], 'pressure.': [1346], 'edema': [1348, 1747], 'rapidly': [1350, 3939], 'become': [1351], 'life-threatening': [1352], 'because': [1353], 'rigid': [1356], 'encasement': [1357], 'brain.': [1360], 'were': [1362, 2045, 2083, 2116, 2228, 2233, 2258, 2286, 2307, 2373, 2471, 2569, 2705, 2770, 2781, 2801, 2816, 2847, 2887, 2912, 2948, 2963, 2981, 3032, 3076, 3171, 3213, 3318, 3329, 3357, 3517, 3524, 3529, 3558, 3573, 3634, 3700, 3707, 3720, 3731, 3736, 3759, 3763, 3831, 3914, 3919, 3932, 3950, 3966, 3973, 3996, 4024, 4049, 4076, 4093, 4119, 4154, 4165, 4228, 4267, 4275, 4290, 4323, 4434, 4458, 4606], 'suggested': [1363], '(27Venero': [1375], 'J.L.': [1376], 'Vizuete': [1377], 'M.L.': [1378], 'Machado': [1379], 'Cano': [1381], 'Prog.': [1383], 'Neurobiol.': [1384], '63:': [1386], '321-336Crossref': [1387], '(181)': [1390], '28Papadopoulos': [1393], 'M.C.': [1394], 'Krishna': [1395], 'Verkman': [1397, 1765, 3252], 'A.S.': [1398, 1766, 3253], 'Mt.': [1399], 'Sinai': [1400], 'Med.': [1402, 1768], '69:': [1404], '242-248PubMed': [1405], '29Badaut': [1408], 'Lasbennes': [1410], 'Magistretti': [1412, 1581, 1837], 'P.J.': [1413, 1582, 1838], 'Regli': [1414, 1583, 1839], 'Cereb.': [1417, 1586, 1842], 'Blood': [1418, 1587, 1843, 3971], 'Flow': [1419, 1588, 1844], 'Metab.': [1420, 1589, 1845], '22:': [1422], '367-378Crossref': [1423], '(451)': [1426], 'Among': [1429], 'them,': [1430], 'numerous': [1431], 'indicated': [1433, 2237, 2275], '(30Endo': [1439], 'Jain': [1441], 'R.K.': [1442], 'Witwer': [1443], 'Brown': [1445], 'Microvasc.': [1447], '1999;': [1449, 2430], '58:': [1450], '89-98Crossref': [1451], '(165)': [1454], '31Markert': [1457], 'J.M.': [1458, 2386], 'Fuller': [1459], 'Gillespie': [1461], 'G.Y.': [1462], 'Bubien': [1463], 'J.K.': [1464], 'McLean': [1465], 'L.A.': [1466], 'Hong': [1467], 'Gullans': [1471], 'S.R.': [1472], 'Mapstone': [1473], 'T.B.': [1474], 'Benos': [1475], 'D.J.': [1476], 'Genomics.': [1478, 3254], '5:': [1480], '21-33Crossref': [1481], '(198)': [1484], '(32Ke': [1488, 1623, 1675], 'Poon': [1490, 1625, 1677], 'W.S.': [1491, 1626, 1678], 'Ng': [1492, 1627, 1679], 'H.K.': [1493, 1628, 1680], 'Pang': [1494, 1629, 1681], 'J.C.': [1495, 1630, 1682], 'Chan': [1496, 1631, 1683, 1763], 'Neurosci.': [1498, 1524, 1633, 1659, 1685], 'Lett.': [1499, 1525, 1634, 1660, 1686], '301:': [1501, 1636, 1688], '21-24Crossref': [1502, 1637, 1689], '(140)': [1505, 1640, 1692], '33Kiening': [1508, 1643], 'K.L.': [1509, 1644], 'van': [1510, 1645], 'Landeghem': [1511, 1646], 'F.K.': [1512, 1647], 'Schreiber': [1513, 1648], 'Thomale': [1515, 1650], 'U.W.': [1516, 1651], 'von': [1517, 1652], 'Deimling': [1518, 1653], 'Unterberg': [1520, 1655], 'A.W.': [1521, 1656, 1762], 'Stover': [1522, 1657], 'J.F.': [1523, 1658], '324:': [1527, 1662], '105-108Crossref': [1528, 1663], '34Taniguchi': [1534, 1695], 'Yamashita': [1536, 1697], 'Kumura': [1538, 1699], 'Tamatani': [1540, 1701], 'Kobayashi': [1542, 1703], 'Yokawa': [1544, 1705], 'Maruno': [1546, 1707], 'Ohnishi': [1550, 1711], 'Kohmura': [1552, 1713], 'Tohyama': [1554, 1715], 'Yoshimine': [1556, 1717], '78:': [1564, 1725], '131-137Crossref': [1565, 1726], '(240)': [1568, 1729], '(35Badaut': [1573, 1829], 'Hirt': [1575, 1831], 'Granziera': [1577, 1833], 'Bogousslavsky': [1579, 1835], '21:': [1591, 1847], '477-482Crossref': [1592, 1848], '(161)': [1595, 1851], 'Scholar)': [1597, 1668], 'swelling,': [1603], 'other': [1605], 'experimental': [1606, 3827], 'interventions.': [1607], 'cortex': [1614, 1982], 'decreased': [1615], 'acute': [1618], 'phase': [1619, 1674], 'injury': [1622], 'later': [1673], 'AQP4-deficient': [1732], 'mice': [1733, 1750], 'survive': [1734], 'much': [1735], 'longer': [1736], 'better': [1740], 'neurological': [1741], 'outcome': [1742], 'from': [1743, 2047, 2288, 3347, 3934, 3952, 3993], 'experimentally': [1744], 'wild-type': [1749], '(36Manley': [1751], 'G.T.': [1752], 'Fujimura': [1753], 'Ma': [1755], 'Noshita': [1757], 'Filiz': [1759], 'Bollen': [1761], 'Nat.': [1767], '6:': [1770], '159-163Crossref': [1771], '(1311)': [1774], 'tightly': [1781, 3820], 'associated': [1782], 'blood-brain': [1785], 'barrier': [1786], '(37Nico': [1787], 'Frigeri': [1789], 'Nicchia': [1791], 'G.P.': [1792], 'Quondamatteo': [1793], 'Herken': [1795], 'R.': [1796, 2062, 2444], 'Errede': [1797], 'Ribatti': [1799], 'Svelto': [1801], 'Roncali': [1803], '114:': [1809], '1297-1307PubMed': [1810], 'cortex,': [1816, 3959], 'astrocyte-specific': [1817], 'appears': [1819], 'infarct': [1822], 'border': [1823], 'zone': [1824], 'transient': [1826, 3623], 'ischemic': [1827], 'stroke': [1828], 'Hyperosmotic': [1854, 2206, 4304], 'solutions': [1855], 'so': [1865], 'it': [1866], 'elucidate': [1870], 'relationship': [1872], 'between': [1873], 'hyperosmolarity': [1879], 'mannitol.': [1882, 4404, 4427, 4442, 4582], 'study': [1884, 2010], 'was': [1885, 2243, 2279, 2496, 2538, 2695, 2717, 2751, 2791, 3002, 3051, 3201, 3245, 3388, 3398, 3428, 3467, 3491, 3537, 3616, 3685, 3785, 3812, 3885, 3897, 3906, 3979, 4056, 4204, 4248, 4631], 'designed': [1886, 2311], 'assess': [1888], 'effects': [1890, 4308], 'on': [1897, 2577, 2878, 2937, 3531, 3575, 4312], 'identify': [1906], 'localized': [1923], 'We': [1963, 2007], 'demonstrated': [1989], 'requires': [1993, 4593], 'selective': [1994], 'activation': [1995], 'involvement': [1997], 'pathway': [2002], 'believe': [2008], 'provides': [2011], 'first': [2013, 2024, 3436, 3502], 'example': [2014], 'pathway.': [2039], 'Culture—Cultures': [2041], 'cortical': [2043, 2081], 'prepared': [2046, 4050], 'postnatal': [2049], 'cortices': [2050], '(P2)': [2051], 'according': [2052, 2312, 3430], 'previously': [2054, 2330, 3249, 3794], 'described': [2055, 2329, 3248, 3793, 3948, 3988], 'methods': [2056], '(38Kato': [2057], 'Chiu': [2059], 'T.C.': [2060], 'Lim': [2061], 'Troy': [2063], 'S.S.': [2064], 'Turriff': [2065], 'D.E.': [2066], '1979;': [2070], '579:': [2071], '216-227Crossref': [2072], '(66)': [2075], 'Trypsinized': [2078], 'dissociated': [2080], '75-cm2': [2086], 'culture': [2087, 2123], 'flasks': [2088], '(Corning': [2089], 'Glass)': [2090], 'containing': [2091, 2739, 2856, 3154, 3196, 3367, 3605, 3680, 4147, 4216, 4463, 4603], '(1000': [2094], 'mg/liter)': [2095], 'medium': [2099, 2219, 2242, 3653, 4328, 4341, 4462, 4602], '(l-DMEM;': [2100], 'Invitrogen)': [2101], 'supplemented': [2102, 3628, 4342], '10%': [2104, 3630, 4360, 4403, 4441], 'fetal': [2105, 3631, 3682], 'bovine': [2106, 3632, 3683, 4149], 'serum': [2107, 3633, 3684, 4103, 4117, 4150], '(Sigma).': [2108], 'After': [2109, 3158, 3673, 3702, 4068, 4194, 4501], 'incubation': [2110], '5–7': [2112], 'days,': [2113, 4033], 'trypsinized': [2117], 'subcultured': [2119], '60-mm': [2121], 'diameter': [2122], 'dishes': [2124], '(Falcon;': [2125], 'PGC': [2126], 'Scientific,': [2127], 'Frederick,': [2128], 'MD).': [2129], 'population': [2132], 'consisted': [2133, 3438], 'over': [2135], '95%': [2136, 2269], 'determined': [2139, 3214], 'immunocytochemical': [2141], 'staining': [2142, 2574], 'anti-glial': [2144], '(GFAP)': [2148], 'antibody.': [2149], 'neural': [2151], 'cells,': [2152], 'expressed': [2157, 2782, 2792, 4235], 'neurons,': [2163], 'oligodendrocytes,': [2164], 'microglia': [2166], 'Stress': [2207], 'Cultured': [2209, 4299], 'Rat': [2210, 4300], 'Astrocytes—When': [2211], 'astrocyte': [2212], 'cultures': [2213, 2232, 2257], 'became': [2214], 'confluent,': [2215], 'equal': [2216, 3691], 'volumes': [2217, 3692], 'without': [2222, 4610], 'concentrations': [2224], '(Sigma)': [2227, 4214], 'added,': [2229], 'incubated': [2234, 3077, 3172, 3645, 4120, 4172, 4186, 4324, 4599], 'times.': [2238], 'Osmolality': [2239], 'measured': [2244, 3003, 3721, 3980], 'freezing': [2247, 3983], 'point': [2248, 3984], 'depression': [2249, 3985], 'method': [2250, 3986, 4003, 4061], '(Osmostat™': [2251], 'OM-6040;': [2252], 'ARKREY,': [2253], 'Kyoto,': [2254], 'Japan).': [2255, 4067, 4162], 'maintained': [2259], 'at': [2260, 2707, 2720, 2760, 2765, 2831, 2835, 2880, 2889, 2939, 2953, 2957, 3636, 4028, 4121, 4241, 4546, 4557, 4567], '37': [2261], '°C': [2262, 3441, 3451, 3456, 3462, 4030], 'atmosphere': [2265], '5%': [2267, 3058, 3155, 3197], 'CO2,': [2268], 'air.': [2270], 'Reverse': [2271], 'Transcription': [2272], '(RT)-PCR—At': [2273], 'times,': [2276, 4183, 4271], 'total': [2277, 2292, 4372], 'RNA': [2278, 2293, 4373], 'isolated': [2280, 3246, 3390, 3399], 'using': [2281, 2502, 2544, 2753, 2775, 3004, 3203, 3217, 3400, 3497, 3590, 3666, 3787, 3890, 4058], 'Trizol': [2282], 'reagent': [2283, 3009], '(Invitrogen).': [2284, 2305, 3672], 'cDNAs': [2285], 'generated': [2287], '1': [2289, 2924, 3055, 3174, 3302, 3355, 3443, 3498, 3637, 3667, 3851, 3855, 4125], 'μg': [2290, 3013, 3021, 3026, 3656, 3663], 'Superscript': [2295], 'II': [2296], 'RNase': [2297], 'H–': [2298], 'transcriptase': [2300], '(Invitrogen)': [2301], 'primed': [2302], 'oligo(dT)18': [2304], 'They': [2306, 4092], 'amplified': [2308], 'primers': [2310, 2321, 2372], 'published': [2315], 'sequences.': [2316], 'PCR': [2318, 2567, 2693, 2799, 3427, 3437, 3490, 3503, 3515], 'protocols': [2319, 3735], 'AQP4,': [2323, 2795, 3180], 'AQP9,': [2324, 2796, 3023], 'β-actin': [2326, 2440, 2475, 2798], 'oligonucleotide': [2371], 'follows:': [2375], '(39Jung': [2377], 'J.S.': [2378], 'Bhat': [2379], 'R.V.': [2380], 'Preston': [2381], 'G.M.': [2382], 'Guggino': [2383], 'W.B.': [2384], 'Baraban': [2385], '91:': [2397], '13052-13056Crossref': [2398], '(630)': [2401], '5′-TTGGACCAATCATAGGCGC-3′': [2404], '(forward)': [2405, 2436, 2465], '5′-GGTCAATGTCGATCACATGC-3′': [2407], '(reverse);': [2408, 2439], '(40Ko': [2410], 'S.B.': [2411], 'Naruse': [2414], 'Ishibashi': [2418], 'Hayakawa': [2422], '47:': [2431], '309-318PubMed': [2432], '5′-GATGCCTTCTGAGAAGGACG-3′': [2435], '5′-AGAGAGCCATCACGACTGC-3′': [2438], '(41Nudel': [2441], 'Zakut': [2443], 'Shani': [2445], 'Neuman': [2447], 'Levy': [2449], 'Yaffe': [2451], 'Nucleic': [2453], 'Acids': [2454], '1983;': [2456], '11:': [2457], '1759-1771Crossref': [2458], '(1018)': [2461], '5′-GACCTGACTGACTACCTCAT-3′': [2464], '5′-TCGTCATACTCCTGCTTGCT-3′': [2467], '(reverse).': [2468], 'Multitarget': [2469], 'PCRs': [2470], 'performed': [2472, 3429, 3530, 3786, 4249], 'coamplifying': [2474], 'internal': [2478, 3620], 'standard.': [2479], 'reaction': [2481, 2491, 2495, 2523, 2533, 2537, 4203], 'mixture': [2482, 2524], 'contained': [2485, 2527], '2': [2486, 2528, 2868, 3859], 'μl': [2487, 2529, 2691, 2851, 2897, 2916, 2969, 2992, 3475, 3499, 3668, 3677], 'RT': [2490, 2532], 'product,': [2492, 2534], 'carried': [2497, 2539, 2718, 4268], 'out': [2498, 2540, 2719, 4269], '20': [2500, 2714, 3020], 'cycles,': [2501, 2543], '95': [2504, 2546], '°C,': [2505, 2511, 2518, 2547, 2553, 2560, 2959], '30-s': [2506, 2512, 2548, 2554], 'denaturing': [2507, 2549], 'step;': [2508, 2514, 2550, 2556], '57': [2510], 'annealing': [2513, 2555], '72': [2517, 2559], '1-min': [2519, 2561], 'extension': [2520, 2562], 'step.': [2521, 2563], '27': [2542], '58': [2552], 'Semiquantification': [2564], 'mRNA—The': [2566], 'products': [2568, 2694, 2800, 3516], 'visualized': [2570, 2771, 3202, 4057], 'ethidium': [2572], 'bromide': [2573], 'following': [2575], 'separation': [2576], '1.5%': [2578], 'agarose': [2579], 'gels': [2580], 'quantified': [2582], 'laser-induced': [2584, 2591], 'fluorescence-linked': [2585, 2592], 'capillary': [2586, 2593, 2728], 'gel': [2587, 2594, 2737, 3037], 'electrophoresis.': [2588], 'Details': [2589], 'electrophoresis': [2595, 2736, 3038], 'reported': [2598], 'elsewhere': [2599], '42Yamamoto': [2639], '104:': [2655], '96-102Crossref': [2656], '43Yamamoto': [2662], 'Miyachi': [2666], 'Inagaki': [2668], '95:': [2682], '110-116Crossref': [2683], '(71)': [2686], 'Briefly,': [2689, 3395, 4022], '40': [2690], 'applied': [2696], 'P/ACE': [2699], 'system': [2700, 3207, 3595], '5010': [2701], '(Beckman': [2702], 'Instruments).': [2703], 'Samples': [2704, 2886, 3941], 'injected': [2706], '0.5': [2711], 'p.s.i.g.': [2712], 's.': [2715, 2885, 2944], 'Separation': [2716], '9.4': [2721], 'kV': [2722], '35': [2724], 'min': [2725, 2830, 2894, 2952, 3166, 3444, 3465, 4087, 4106, 4175], '(47': [2729], 'cm': [2730], 'long,': [2731], '100-μm': [2732], 'diameter)': [2733], 'filled': [2734], 'buffer': [2738, 2918, 2973, 2996, 3195], 'fluorescence': [2741, 2749, 2785], 'stain': [2742], '(LIFluor': [2743], 'dsDNA': [2744], '1000': [2745], 'kit;': [2746], 'Beckman).': [2747], 'Laser-induced': [2748], 'detection': [2750, 3206], 'preformed': [2752], 'argon-ion': [2755], 'laser': [2756], 'source': [2757], 'excitation': [2759], '488': [2761], 'nm': [2762], 'emission': [2764], '520': [2766], 'nm.': [2767], 'chromatograms': [2769], 'analyzed': [2773, 4276], 'automatically': [2774], 'GOLD': [2776], 'Software': [2777], '(Beckman).': [2778], 'peaks': [2780], 'relative': [2784], 'units,': [2786], 'retention': [2789], 'time': [2790, 4446], 'minutes.': [2794], 'compared': [2802], 'integrating': [2804], 'each': [2805, 3167, 4176], 'peak': [2806], 'area.': [2807], 'Western': [2808, 3943], 'Blot': [2809, 3047], 'Analysis—Cells': [2810], 'specified': [2814], 'harvested': [2817], 'Ca2+-': [2819], 'Mg2+-free': [2821], 'phosphate-buffered': [2822], 'saline': [2823, 2854], '(PBS': [2824], '(-))': [2825], 'centrifuged': [2827, 2949], '10': [2829, 2861, 2865, 2884, 2928, 2932, 2943, 3477, 4105, 4222], '800': [2832], '×': [2833, 2955, 3638, 4337], 'g': [2834, 2956], '4': [2836, 2958, 3464, 3674, 4029], '°C.': [2837], 'For': [2838, 2902, 2977, 3622], 'quantitation': [2839, 2903], 'protein,': [2844], 'pellets': [2846, 2911, 2980], 'suspended': [2848, 2913, 2982], '100': [2850], 'Tris-buffered': [2853], '(TBS)': [2855], '200': [2857], 'mm': [2858, 2869, 2920, 2925, 3064, 3069, 3964, 4223], 'phenylmethanesulfonyl': [2859, 2926], 'fluoride,': [2860, 2927], 'μm': [2862, 2866, 2929, 2933, 4047], 'pepstatin': [2863, 2930], 'A,': [2864, 2931], 'leupeptin,': [2867], 'EDTA,': [2870], '0.5%': [2872], 'Nonidet': [2873], 'P-40': [2874], 'then': [2876, 3052, 3832, 4041, 4094, 4185], 'sonicated': [2877, 2936, 2984], 'ice': [2879, 2938], '8-watt': [2881, 2940], 'output': [2882, 2941], 'kept': [2888], 'room': [2890, 4122], 'temperature': [2891, 4123], '15': [2893, 3165, 3453, 4192], 'SDS': [2899, 2971, 2994], 'sample': [2900, 2972, 2995], 'buffer.': [2901], 'phosphorylated': [2907, 3030], 'MAPKs,': [2908, 3181], '150': [2915, 3676], '(50': [2919], 'Tris-HCl,': [2921], 'pH': [2922, 3066], '7.4,': [2923], 'leupeptin)': [2934], 'lysates': [2947], '30': [2951, 3025, 3447, 3458, 4086, 4174], '15,000': [2954], 'supernatants': [2962], 'collected': [2964], 'boiled': [2966, 2989], 'min.': [2976, 2999, 4193], 'Total': [3000], 'BCA': [3006], 'assay': [3008, 3594], 'kit': [3010, 3406], '(Pierce).': [3011], '3': [3012, 4032, 4046], 'separated': [3033], '12.5%': [3035], 'SDS-polyacrylamide': [3036], '(ATTO,': [3039], 'Tokyo,': [3040, 3365, 4066], 'Japan)': [3041, 3366], 'transferred': [3043], 'Clear': [3046], 'Membrane-P': [3048], '(ATTO),': [3049], 'blocked': [3053], 'h': [3056, 3175, 3688, 4126, 4368, 4481, 4496, 4518, 4538, 4569, 4578], 'skim': [3059, 3156, 3198], 'milk': [3060], 'TBS-T': [3062, 3153, 3194], '(20': [3063, 3810], 'Tris,': [3065], '7.6,': [3067], '137': [3068], 'NaCl,': [3070, 3846], '0.1%': [3071], 'Tween': [3072], '20).': [3073], 'overnight': [3078], 'anti-AQP4': [3080, 4128], 'antibody': [3081, 3090, 3096, 3108, 3118, 3124, 3131, 3139, 3147, 3192, 4129, 4134, 4140], '(Chemicon': [3082], 'International,': [3083], 'Inc.,': [3084, 3112], 'Temecula,': [3085], 'CA)': [3086, 3102], 'diluted': [3087, 3092, 3103, 3115, 3120, 3128, 3135, 3143, 3149, 3178, 3186, 4131, 4136, 4142], '1:750,': [3088], 'anti-AQP9': [3089, 4133], '(Chemicon)': [3091, 3148, 4130, 4135, 4141], '1:500,': [3093, 3104, 3136], 'anti-p38': [3094], '(Santa': [3097, 3132], 'Cruz': [3098, 3133], 'Biotechnology,': [3099], 'Santa': [3100], 'Cruz,': [3101], 'anti-phosphorylated': [3105, 3122, 3137], '(Cell': [3109, 3125, 3140], 'Signaling': [3110, 3126, 3141], 'Technology,': [3111], 'Beverly,': [3113], 'MA)': [3114], '1:1000,': [3116, 3129, 3144], 'anti-ERK': [3117], '(Promega)': [3119, 3604], '1:5000,': [3121], 'Technology)': [3127, 3142], 'anti-JNK': [3130], 'Biotechnology)': [3134], 'anti-GFAP': [3146, 4139], '1:1000': [3150, 3177], 'milk.': [3157, 3199], 'washing': [3159, 4069, 4195], 'times': [3163, 4168], 'TBS-T,': [3169], '(for': [3179, 3187], 'GFAP)': [3183], '1:500': [3185], 'AQP9)': [3188], 'horseradish': [3189], 'peroxidase-conjugated': [3190], 'secondary': [3191, 4179], 'Protein': [3200], 'ECL': [3205], '(Amersham': [3208], 'Biosciences).': [3209], 'Relative': [3210], 'band': [3211], 'intensities': [3212], 'densitometry': [3216], 'Kodak': [3218, 3225], 'Digital': [3219], 'Science': [3220], '1D': [3221], 'version': [3222], '2.0': [3223], '(Eastman': [3224], 'Co.).': [3226], 'Isolation': [3227], '5′-Flanking': [3230], 'Regions': [3231], 'Human': [3233], 'Genes—The': [3237], '5′-flanking': [3238, 3278], 'region': [3239, 3374, 3397, 3955], 'human': [3242, 3414], 'gene': [3244, 3265, 3579, 3609, 4265, 4554], '(44Umenishi': [3250], '50:': [3256], '373-377Crossref': [3257], '(58)': [3260], 'alternative': [3269], 'promoters': [3270], 'upstream': [3271, 3582], 'exons': [3273], '0': [3274, 3283, 3342], '1.': [3276], 'regions': [3279], 'exon': [3282, 3297, 3301, 3316, 3341, 3354], 'promoter': [3284, 3303, 3343, 3356, 3373, 3555, 3615], '(bp': [3285, 3304, 3377], '–1930': [3286, 3336], '+29)': [3288], '(nucleotide': [3289, 3308, 3381], '+1': [3290, 3309, 3382], 'corresponds': [3291, 3310, 3383], 'initiation': [3294, 3313, 3386], 'codon': [3295, 3314], '0)': [3298], '–297': [3305, 3349], '+113)': [3307], '1)': [3317], 'subcloned': [3319, 3518], 'into': [3320, 3519, 3814], 'vector': [3322, 3362, 3563], 'pCR2.1': [3323], '(Invitrogen),': [3324], '5′': [3326], 'deletion': [3327], 'mutants': [3328, 3332, 3545], 'constructed.': [3330], 'Deletion': [3331, 3544], 'corresponding': [3333, 3546], 'bp': [3335, 3348, 3548], '+29': [3338], '(eight': [3344], 'constructs)': [3345, 3557], '+133': [3351], 'fused': [3358, 3559, 3581], 'promoterless': [3361, 3562], 'PGV-B': [3363, 3589], '(Toyo-ink,': [3364], 'luciferase': [3369, 3586, 3608, 3716, 3719], 'reporter': [3370, 3587, 3593], 'gene.': [3371], '–1125': [3378, 3549], '+55)': [3380], 'codon)': [3387], 'also': [3389], 'method.': [3394], 'Promoter': [3402], 'Finder': [3403], 'Walking': [3405], '(Clontech,': [3407], 'Palo': [3408], 'Alto,': [3409], 'CA),': [3410], 'contains': [3412], 'adapter-linked': [3413], 'genomic': [3415], 'digested': [3417], 'EcoRV,': [3419], 'ScaI,': [3420], 'DraI,': [3421], 'PvuII,': [3422], 'SspI.': [3424], 'A': [3425, 3807], 'two-step': [3426], "manufacturer's": [3433], 'instructions.': [3434], '94': [3440, 3450], 'followed': [3445], 'cycles': [3448], 's,': [3454, 3459], '60': [3455], '68': [3461], 'done': [3468, 3492, 3574, 3946], 'final': [3471], '50': [3474], 'pmol': [3478], 'specific': [3481, 3507], 'primer,': [3482, 3508], '5′-GCTCTTCAAGACCAGTCTCTGCTTGA-3′': [3483], '(nucleotides': [3484, 3510], '+60': [3485], '+46).': [3487], 'second': [3489], 'protocol': [3496], 'product': [3504], '5′-CTCTGAGGACTCCTGTTTCTACCAAT-3′': [3509], '–11': [3511], '–35).': [3513], 'pCR2.1,': [3520], 'both': [3522, 4504, 4558, 4625], 'strands': [3523], 'sequenced': [3525], 'completely.': [3526], 'BLAST': [3527], 'searches': [3528], 'NCBI': [3533], 'sites.': [3534], 'sequence': [3536], 'identical': [3538], 'GenBank™': [3540], 'accession': [3541], 'number': [3542], 'AC025431.': [3543], '+55': [3551], '(four': [3556], 'PGV-B.': [3564], 'Transfection': [3566], 'Luciferase': [3568], 'Reporter': [3569, 4264], 'Gene': [3570], 'Assay—Reporter': [3571], 'assays': [3572, 4266], 'fragments': [3580], 'firefly': [3585, 3718], 'Dual-Luciferase': [3592], '(Promega),': [3596], 'pRL-thymidine': [3600], '(TK)': [3602], 'plasmid': [3603, 3660], 'Renilla': [3607, 3715], 'TK': [3614], 'co-transfected': [3617], 'control.': [3621], 'transfection,': [3624, 3690], 'l-DMEM': [3627, 3679, 3694, 3699], 'plated': [3635], '105': [3639], 'cells/well': [3640], '48-well': [3643], 'plate,': [3644], '18': [3647, 3863], 'h,': [3648, 3675, 3704, 4503], 'transfected': [3650], 'serum-free': [3652], '0.4': [3655], 'test': [3659, 4259, 4280], '0.01': [3662], 'pRL-TK': [3665], 'Lipofect-AMINE': [3670], '2000': [3671], '20%': [3681], 'added.': [3686, 3701], '48': [3687], '3%': [3696, 4354, 4417, 4464, 4604], '24': [3703, 4502, 4537, 4577], 'washed': [3708], 'harvested.': [3710], 'activities': [3712], 'triplicate.': [3723], 'Induction': [3724, 4293], 'Hyperosmolarity': [3726], 'Rats—All': [3728], 'undertaken': [3732], 'approved': [3737], 'Animals': [3740, 3762], 'Care': [3741], 'Use': [3743], 'Committee': [3744], 'Nagoya': [3746], 'City': [3747], 'University': [3748], 'Graduate': [3749], 'School': [3750], 'Medical': [3752], 'Sciences.': [3753], 'Male': [3754], 'Wistar': [3755], 'rats': [3756], '(150': [3757], 'g)': [3758], 'throughout.': [3761], 'anesthetized': [3764, 3915], 'pentobarbital': [3766], '(Schering-Plough': [3767], 'Animal': [3768], 'Health,': [3769], 'Kenilworth,': [3770], 'NJ)': [3771], '(3.2': [3772], 'mg/100': [3773], 'g,': [3774], 'body': [3775], 'weight)': [3776], 'placed': [3778], 'heating': [3781, 3838], 'lamp.': [3782, 3839], 'Intraperitoneal': [3783], 'modification': [3789], 'technique': [3792], '(45Bedford': [3795], 'J.J.': [3796], 'Leader': [3797], 'J.P.': [3798], '264:': [3803], 'R1164-R1179PubMed': [3804], 'polyurethane': [3808], 'catheter': [3809], 'gauge)': [3811], 'inserted': [3813], 'peritoneum': [3816], 'puncture': [3818], 'fixed': [3821, 4025], 'avoid': [3823], 'leakage': [3824], 'solution.': [3828, 3923], 'animals': [3830, 3913, 3931], 'allowed': [3833], 'recover': [3835], 'An': [3840], 'isosmotic': [3841, 3883, 4326], 'solution': [3842, 3875, 4215], '(121': [3843], 'mmol': [3844, 3848, 3852, 3856, 3860, 3865, 3868], 'KCl,': [3850], 'MgCl2,': [3854], 'NaH2PO4,': [3858], 'CaCl2,': [3862], 'NaHCO3,': [3866], '22': [3867], 'glucose)': [3870], '(1.1': [3876], 'mol': [3877], 'added': [3880], 'solution)': [3884], 'administered': [3886, 3921], 'pump.': [3893], 'rate': [3896], '1.9': [3898], 'ml/h,': [3899], 'duration': [3902], '6': [3910, 4367, 4517, 4619], 'h.': [3911, 4620], 'Control': [3912, 4152], 'cannulated': [3917], 'At': [3924], 'conclusion': [3926], 'experiments,': [3929], 'disconnected': [3933], 'pump': [3937], 'decapitated.': [3940], 'blot': [3944], 'analyses,': [3945], 'above,': [3949], 'obtained': [3951, 3967], 'superficial': [3954], 'cerebral': [3961], 'sections': [3962, 3992, 4071, 4153, 4164, 4197, 4227], '(5': [3963], 'thick)': [3965], 'immunohistochemical': [3969], 'staining.': [3970], 'samples': [3972], 'removed,': [3974], 'plasma': [3976], 'above.': [3989], 'Immunohistochemical': [3990], 'Staining—Coronal': [3991], 'embedded': [3997, 4042], 'paraffin': [3999], 'AMeX': [4002], '(46Sato': [4004], 'Mukai': [4006], 'Watanabe': [4008], 'Goto': [4010], 'Shimosato': [4012], 'Pathol.': [4016], '1986;': [4017], '125:': [4018], '431-435PubMed': [4019], 'tissues': [4023], 'acetone': [4027], 'cleared': [4034], 'methyl': [4036], 'benzoate': [4037], 'xylene,': [4039], 'paraffin.': [4044], 'Sections': [4045], 'thick': [4048], 'deparaffinized': [4052], 'xylene.': [4054], 'Immunoreactivity': [4055], 'streptavidin/biotin': [4060], '(Histofine': [4062], 'SAB-PO': [4063], 'Kit,': [4064], 'Nichirei,': [4065], 'PBS': [4073, 4145, 4170, 4199], '(–),': [4074, 4171, 4200], 'treated': [4077, 4155, 4459, 4607], '0.3%': [4079, 4344], '(v/v)': [4080, 4218], 'hydrogen': [4081, 4219], 'peroxide': [4082, 4220], 'methanol': [4084], 'inactivate': [4089], 'endogenous': [4090], 'peroxidase.': [4091], 'immersed': [4095], '1:20': [4098], 'dilution': [4099], 'nonimmune': [4101, 4157], 'goat': [4102], 'block': [4108], 'binding,': [4110], 'blotting': [4113], 'remove': [4115], 'excess': [4116], '1:400,': [4132], '1:100,': [4137], '1:50': [4143], '(–)': [4146], '1%': [4148, 4349, 4426], 'albumin.': [4151], 'rabbit': [4158], 'immunoglobulins': [4159], '(MBL,': [4160], 'Nagoya,': [4161], 'rinsed': [4166, 4181], 'three': [4167, 4182, 4270], 'antibody,': [4180], 'streptavidin-biotin-peroxidase': [4189], 'complex': [4190], 'peroxidase': [4202], 'developed': [4205], 'incubating': [4207], '0.02%': [4210], '(w/v)': [4211], '3,3′-diaminobenzidine': [4212], 'tetrahydrochloride': [4213], '0.003%': [4217], 'sodium': [4224], 'azide.': [4225], 'counterstained': [4229], 'hematoxylin.': [4231], 'Data': [4232], 'Analysis—Data': [4233], 'means': [4237], '±': [4238, 4333, 4346, 4351, 4356, 4363], 'S.E.': [4239], 'least': [4242], 'independent': [4244], 'experiments.': [4245], 'Statistical': [4246], 'analysis': [4247, 4253], 'one-way': [4251], 'factorial': [4252], 'variance': [4255], 'combined': [4256], "Scheffe's": [4258], 'comparison': [4262], 'pairs.': [4263], 'results': [4274], "Student's": [4278], 't': [4279], 'statistical': [4282], 'significance.': [4283], 'Differences': [4284], 'p': [4286], 'values': [4287], '<': [4288], '0.05': [4289], 'considered': [4291], 'significant.': [4292], 'Astrocytes': [4301], 'Subjected': [4302], 'Stress—To': [4305], 'examine': [4306], 'mRNAs': [4319, 4385, 4408, 4431, 4506, 4592, 4627], '(final': [4329], '311': [4332], '1.4': [4334], 'mOsm': [4335], '(n': [4336], '4))': [4338], '(324': [4345], '1.6': [4347], 'mOsm),': [4348, 4353, 4358], '(363': [4350], '2.7': [4352], '(491': [4355], '4.7': [4357], '(854': [4362], '8.9': [4364], 'mOsm)': [4365], 'before': [4369], 'isolation': [4370], 'RT-PCR': [4375], 'harvesting': [4377], 'immunoblot': [4379], 'analysis.': [4380], 'Both': [4381], '(Fig.': [4386, 4390, 4499, 4523], '1A)': [4387], 'B': [4392, 4525], 'C)': [4394], 'significantly': [4396, 4474, 4490], 'maximally': [4413], 'mannitol,': [4418, 4485, 4542], 'whereas': [4419], 'peaked': [4422, 4566], 'lesser': [4438], 'extent': [4439], 'To': [4443, 4583], 'analyze': [4444], 'course': [4447], 'mannitol-mediated': [4450], 'expression,': [4456], 'periods': [4468], 'time.': [4470], 'mRNA': [4472, 4488, 4530], '6,': [4478, 4493], '12': [4480, 4495, 4568], '2A).': [4500], 'returned': [4507, 4531, 4571], 'base-line': [4509, 4534, 4574], 'levels.': [4510, 4563], 'C).': [4527], 'Although': [4528], 'level': [4535, 4575], 'remained': [4545], 'high': [4549], 'level,': [4550], 'suggesting': [4551], 'transcriptional': [4560], 'post-transcriptional': [4562], 'see': [4584], 'whether': [4585], 'de': [4594], 'novo': [4595], 'synthesis,': [4597], 'synthesis': [4613], 'cycloheximide': [4615], '(25': [4616], 'μg/ml),': [4617]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2060802422', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 16}], 'updated_date': '2025-01-05T08:11:29.016812', 'created_date': '2016-06-24'}