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'abstract_inverted_index': {'High-fidelity': [0], 'DNA': [1, 4, 30, 63, 102], 'polymerases': [2], 'copy': [3], 'rapidly': [5], 'and': [6, 65, 87, 157], 'accurately': [7], 'by': [8, 32, 61, 140], 'adding': [9], 'correct': [10], 'deoxynucleotide': [11], 'triphosphates': [12], 'to': [13, 101, 129, 174], 'a': [14, 23, 56, 94, 131, 169], 'growing': [15], 'primer': [16], 'strand': [17], 'of': [18, 25, 44, 55, 68, 112, 122, 125, 134, 143, 153, 155], 'DNA.': [19], 'Following': [20], 'nucleotide': [21], 'incorporation,': [22], 'series': [24], 'conformational': [26], 'changes': [27], 'translocate': [28], 'the': [29, 38, 41, 51, 62, 66, 69, 73, 80, 84, 89, 114, 120, 126, 135, 141, 150, 158], 'substrate': [31], 'one': [33, 111], 'base': [34, 71], 'pair': [35], 'step,': [36], 'readying': [37], 'polymerase': [39, 57, 99], 'for': [40], 'next': [42], 'round': [43], 'incorporation.': [45], 'Molecular': [46], 'dynamics': [47], 'simulations': [48], 'indicate': [49], 'that': [50, 79, 88, 168], 'translocation': [52, 127], 'consists': [53], 'globally': [54], 'fingers-opening': [58], 'transition,': [59], 'followed': [60], 'displacement': [64], 'insertion': [67], 'template': [70], 'into': [72], 'preinsertion': [74], 'site.': [75], 'They': [76], 'also': [77], 'show': [78], 'pyrophosphate': [81], 'release': [82], 'facilitates': [83], 'opening': [85, 100], 'transition': [86, 105], 'universally': [90], 'conserved': [91], 'Y714': [92, 156], 'plays': [93], 'key': [95], 'role': [96], 'in': [97, 110, 119], 'coupling': [98], 'translocation.': [103], 'The': [104], 'involves': [106], 'several': [107], 'metastable': [108], 'intermediates': [109], 'which': [113], 'O': [115], 'helix': [116], 'is': [117, 166, 172], 'bent': [118], 'vicinity': [121], 'G711.': [123], 'Completion': [124], 'appears': [128], 'require': [130], 'gating': [132], 'motion': [133], 'O1': [136], 'helix,': [137], 'perhaps': [138], 'facilitated': [139], 'presence': [142], 'G715.': [144], 'These': [145], 'roles': [146], 'are': [147], 'consistent': [148], 'with': [149], 'high': [151], 'level': [152], 'conservation': [154], 'two': [159], 'glycine': [160], 'residues': [161], 'at': [162], 'these': [163], 'positions.': [164], 'It': [165], 'likely': [167], 'corresponding': [170], 'mechanism': [171], 'applicable': [173], 'other': [175], 'polymerases.': [176]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2060732865', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-09-13T02:12:49.243904', 'created_date': '2016-06-24'}