Publication Information

{'id': 'https://openalex.org/W2060310903', 'doi': 'https://doi.org/10.1089/dna.1996.15.17', 'title': 'Thiopurine Methyltransferase Pharmacogenetics: Human Gene Cloning and Characterization of a Common Polymorphism', 'display_name': 'Thiopurine Methyltransferase Pharmacogenetics: Human Gene Cloning and Characterization of a Common Polymorphism', 'publication_year': 1996, 'publication_date': '1996-01-01', 'ids': {'openalex': 'https://openalex.org/W2060310903', 'doi': 'https://doi.org/10.1089/dna.1996.15.17', 'mag': '2060310903', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8561894'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1089/dna.1996.15.17', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S97146013', 'display_name': 'DNA and Cell Biology', 'issn_l': '1044-5498', 'issn': ['1044-5498', '1557-7430'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320443', 'host_organization_name': 'Mary Ann Liebert, Inc.', 'host_organization_lineage': ['https://openalex.org/P4310320443'], 'host_organization_lineage_names': ['Mary Ann Liebert, Inc.'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5109130974', 'display_name': 'Carol L. Szumlanski', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210125099', 'display_name': 'Mayo Clinic in Arizona', 'ror': 'https://ror.org/03jp40720', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723', 'https://openalex.org/I4210125099']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'CAROL SZUMLANSKI', 'raw_affiliation_strings': ['Department of Pharmacology, Mayo Medical School, Rochester, MN 55905, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Mayo Medical School, Rochester, MN 55905, USA.', 'institution_ids': ['https://openalex.org/I4210125099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089570861', 'display_name': 'Diane M. Otterness', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'DIANE OTTERNESS', 'raw_affiliation_strings': ['Mayo Clinic College of Medicine and Science;'], 'affiliations': [{'raw_affiliation_string': 'Mayo Clinic College of Medicine and Science;', 'institution_ids': ['https://openalex.org/I1330342723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002222797', 'display_name': 'Chengtao Her', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'CHENGTAO HER', 'raw_affiliation_strings': ['Mayo Clinic College of Medicine and Science;'], 'affiliations': [{'raw_affiliation_string': 'Mayo Clinic College of Medicine and Science;', 'institution_ids': ['https://openalex.org/I1330342723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100392980', 'display_name': 'Daniel Lee', 'orcid': 'https://orcid.org/0000-0001-9447-4175'}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'DANIEL LEE', 'raw_affiliation_strings': ['Mayo Clinic College of Medicine and Science;'], 'affiliations': [{'raw_affiliation_string': 'Mayo Clinic College of Medicine and Science;', 'institution_ids': ['https://openalex.org/I1330342723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043924504', 'display_name': 'Brigitte Brandriff', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1282311441', 'display_name': 'Lawrence Livermore National Laboratory', 'ror': 'https://ror.org/041nk4h53', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1282311441', 'https://openalex.org/I1330989302', 'https://openalex.org/I198811213', 'https://openalex.org/I4210138311']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'BRIGITTE BRANDRIFF', 'raw_affiliation_strings': ['Lawrence Livermore National Laboratory'], 'affiliations': [{'raw_affiliation_string': 'Lawrence Livermore National Laboratory', 'institution_ids': ['https://openalex.org/I1282311441']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075435082', 'display_name': 'David P. Kelsell', 'orcid': 'https://orcid.org/0000-0002-9910-7144'}, 'institutions': [{'id': 'https://openalex.org/I2801316944', 'display_name': 'Cancer Research UK', 'ror': 'https://ror.org/054225q67', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801316944']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'DAVID KELSELL', 'raw_affiliation_strings': ['Cancer Research UK'], 'affiliations': [{'raw_affiliation_string': 'Cancer Research UK', 'institution_ids': ['https://openalex.org/I2801316944']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111780568', 'display_name': 'N.K. Spurr', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801316944', 'display_name': 'Cancer Research UK', 'ror': 'https://ror.org/054225q67', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801316944']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'NIGEL SPURR', 'raw_affiliation_strings': ['Cancer Research UK'], 'affiliations': [{'raw_affiliation_string': 'Cancer Research UK', 'institution_ids': ['https://openalex.org/I2801316944']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089667999', 'display_name': 'Lynne Lennard', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210102902', 'display_name': 'Sheffield Teaching Hospitals NHS Foundation Trust', 'ror': 'https://ror.org/018hjpz25', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210102902']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'LYNNE LENNARD', 'raw_affiliation_strings': ['Sheffield Teaching Hospitals NHS Foundation Trust'], 'affiliations': [{'raw_affiliation_string': 'Sheffield Teaching Hospitals NHS Foundation Trust', 'institution_ids': ['https://openalex.org/I4210102902']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038929700', 'display_name': 'Eric D. Wieben', 'orcid': 'https://orcid.org/0000-0002-8708-0968'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'ERIC WIEBEN', 'raw_affiliation_strings': ['Biochemistry and Molecular Biology'], 'affiliations': [{'raw_affiliation_string': 'Biochemistry and Molecular Biology', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5056312367', 'display_name': 'Richard M. Weinshilboum', 'orcid': 'https://orcid.org/0000-0002-4911-7985'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'RICHARD WEINSHILBOUM', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 23.88, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 310, 'citation_normalized_percentile': {'value': 0.987147, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '15', 'issue': '1', 'first_page': '17', 'last_page': '30'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10950', 'display_name': 'Acute Lymphoblastic Leukemia research', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10950', 'display_name': 'Acute Lymphoblastic Leukemia research', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10240', 'display_name': 'Plant tissue culture and regeneration', 'score': 0.9782, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12856', 'display_name': 'Transgenic Plants and Applications', 'score': 0.9468, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/thiopurine-methyltransferase', 'display_name': 'Thiopurine methyltransferase', 'score': 0.6173768}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.93902445}, {'id': 'https://openalex.org/C55775858', 'wikidata': 'https://www.wikidata.org/wiki/Q1152227', 'display_name': 'Pharmacogenetics', 'level': 4, 'score': 0.72382617}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.65911853}, {'id': 'https://openalex.org/C70917649', 'wikidata': 'https://www.wikidata.org/wiki/Q94307', 'display_name': 'Thiopurine methyltransferase', 'level': 4, 'score': 0.6173768}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.5487389}, {'id': 'https://openalex.org/C149737253', 'wikidata': 'https://www.wikidata.org/wiki/Q3240252', 'display_name': 'Polymorphism (computer science)', 'level': 4, 'score': 0.541092}, {'id': 'https://openalex.org/C91965660', 'wikidata': 'https://www.wikidata.org/wiki/Q415875', 'display_name': 'Methyltransferase', 'level': 4, 'score': 0.53723484}, {'id': 'https://openalex.org/C180754005', 'wikidata': 'https://www.wikidata.org/wiki/Q80726', 'display_name': 'Allele', 'level': 3, 'score': 0.4963377}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.33218324}, {'id': 'https://openalex.org/C135763542', 'wikidata': 'https://www.wikidata.org/wiki/Q106016', 'display_name': 'Genotype', 'level': 3, 'score': 0.31957993}, {'id': 'https://openalex.org/C33288867', 'wikidata': 'https://www.wikidata.org/wiki/Q518328', 'display_name': 'Methylation', 'level': 3, 'score': 0.08808789}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C2778260677', 'wikidata': 'https://www.wikidata.org/wiki/Q917447', 'display_name': 'Inflammatory bowel disease', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D008780', 'descriptor_name': 'Methyltransferases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D011110', 'descriptor_name': 'Polymorphism, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002874', 'descriptor_name': 'Chromosome Mapping', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002896', 'descriptor_name': 'Chromosomes, Human, Pair 6', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003001', 'descriptor_name': 'Cloning, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008780', 'descriptor_name': 'Methyltransferases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016297', 'descriptor_name': 'Mutagenesis, Site-Directed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1089/dna.1996.15.17', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S97146013', 'display_name': 'DNA and Cell Biology', 'issn_l': '1044-5498', 'issn': ['1044-5498', '1557-7430'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320443', 'host_organization_name': 'Mary Ann Liebert, Inc.', 'host_organization_lineage': ['https://openalex.org/P4310320443'], 'host_organization_lineage_names': ['Mary Ann Liebert, Inc.'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8561894', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.55}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 44, 'referenced_works': ['https://openalex.org/W1534517380', 'https://openalex.org/W1546911288', 'https://openalex.org/W1804439789', 'https://openalex.org/W1807718812', 'https://openalex.org/W1823851316', 'https://openalex.org/W1945080506', 'https://openalex.org/W1965051773', 'https://openalex.org/W1965681455', 'https://openalex.org/W1968475920', 'https://openalex.org/W1982479137', 'https://openalex.org/W1984169395', 'https://openalex.org/W1984505053', 'https://openalex.org/W1987666378', 'https://openalex.org/W1998856437', 'https://openalex.org/W2001596861', 'https://openalex.org/W2004174427', 'https://openalex.org/W2009310436', 'https://openalex.org/W2011591714', 'https://openalex.org/W2029841402', 'https://openalex.org/W2031824679', 'https://openalex.org/W2032633489', 'https://openalex.org/W2033250360', 'https://openalex.org/W2034787505', 'https://openalex.org/W2041639550', 'https://openalex.org/W2052241801', 'https://openalex.org/W2058710761', 'https://openalex.org/W2060913542', 'https://openalex.org/W2061171333', 'https://openalex.org/W2061764105', 'https://openalex.org/W2069546278', 'https://openalex.org/W2075888728', 'https://openalex.org/W2084140931', 'https://openalex.org/W2084271415', 'https://openalex.org/W2101108802', 'https://openalex.org/W2104788940', 'https://openalex.org/W2108388593', 'https://openalex.org/W2139952048', 'https://openalex.org/W2220762111', 'https://openalex.org/W2275960818', 'https://openalex.org/W2297993176', 'https://openalex.org/W2399186177', 'https://openalex.org/W2413204086', 'https://openalex.org/W4249227862', 'https://openalex.org/W4293247451'], 'related_works': ['https://openalex.org/W4200038812', 'https://openalex.org/W3023393631', 'https://openalex.org/W2312942321', 'https://openalex.org/W2108849469', 'https://openalex.org/W2093954596', 'https://openalex.org/W2038433580', 'https://openalex.org/W2032457938', 'https://openalex.org/W199358782', 'https://openalex.org/W1481475489', 'https://openalex.org/W126845996'], 'abstract_inverted_index': {'Thiopurine': [0], 'methyltransferase': [1], '(TPMT)': [2], 'catalyzes': [3], 'the': [4, 12, 41, 45, 57, 66, 70, 79, 85, 107, 119, 146, 181, 184, 204, 214, 217, 228, 234, 255, 341, 397, 402, 411, 431, 469, 477, 497, 502], 'S-methylation': [5], 'of': [6, 17, 30, 40, 44, 48, 88, 174, 183, 186, 189, 208, 216, 236, 343, 414, 423, 430, 456, 468, 476, 511], 'thiopurine': [7], 'drugs.': [8], 'Individual': [9], 'variation': [10], 'in': [11, 36, 61, 156, 170, 303, 315, 321, 323, 410, 420, 433, 453, 508], 'toxicity': [13], 'and': [14, 33, 63, 145, 172, 177, 275, 306, 331, 380, 405, 436, 460, 465, 499], 'therapeutic': [15], 'efficacy': [16], 'these': [18, 355], 'drugs': [19], 'is': [20, 124], 'associated': [21], 'with': [22, 230, 245, 251, 270, 279, 285, 327, 345, 354, 367, 386], 'a': [23, 74, 94, 138, 198, 295, 481], 'common': [24, 482], 'genetic': [25, 71, 257, 484], 'polymorphism': [26, 485, 498], 'that': [27, 118, 241, 427, 444], 'controls': [28], 'levels': [29], 'TPMT': [31, 60, 123, 162, 211, 218, 256, 273, 281, 287, 347, 369, 424, 457, 470, 483], 'activity': [32, 274, 288, 348, 370, 389, 459], 'immunoreactive': [34, 461], 'protein': [35, 244], 'human': [37, 127, 139, 364], 'tissues.': [38], 'Because': [39], 'clinical': [42], 'significance': [43], '"pharmacogenetic"': [46], 'regulation': [47], 'this': [49, 512], 'enzyme,': [50], 'it': [51, 114, 223, 489, 506], 'would': [52], 'be': [53, 166, 394], 'important': [54, 513], 'to': [55, 64, 92, 103, 116, 150, 165, 226, 233, 373, 393, 491, 500], 'clone': [56, 133], 'gene': [58, 80, 121, 147, 160, 219, 471], 'for': [59, 69, 81, 106, 122, 161, 254, 291, 396, 401, 480, 496], 'humans': [62], 'study': [65], 'molecular': [67, 478], 'basis': [68, 182, 479], 'polymorphism.': [72, 258], 'As': [73], 'first': [75], 'step': [76], 'toward': [77], 'cloning': [78, 464], 'TPMT,': [82], 'we': [83], 'used': [84, 102], 'rapid': [86], 'amplification': [87, 188], 'genomic': [89, 142], 'DNA': [90, 99, 143, 247, 260, 337, 361], 'ends': [91], 'obtain': [93], 'TPMT-specific': [95], 'intron': [96], 'sequence.': [97, 351], 'That': [98], 'sequence': [100, 376], 'was': [101, 134, 148, 163, 224, 261], 'design': [104], 'primers': [105, 231], 'polymerase': [108], 'chain': [109], 'reaction': [110], '(PCR),': [111], 'which': [112, 505], 'made': [113], 'possible': [115, 225, 490], 'determine': [117, 501], 'active': [120], 'located': [125], 'on': [126], 'chromosome': [128, 140, 151], '6.': [129], 'A': [130, 298, 308], 'TPMT-positive': [131], 'cosmid': [132], 'then': [135], 'isolated': [136, 262, 339], 'from': [137, 203, 249, 263, 266, 340, 362], '6-specific': [141], 'library,': [144], 'sublocalized': [149], 'band': [152], '6p22.3': [153], 'by': [154, 504], 'fluorescence': [155], 'situ': [157], 'hybridization.': [158], 'The': [159], 'found': [164, 372], 'approximately': [167], '34': [168], 'kb': [169], 'length': [171], 'consisted': [173], '10': [175, 407], 'exons': [176, 434], '9': [178], 'introns.': [179], 'On': [180], 'results': [185, 507], '5′-rapid': [187], 'cDNA': [190], 'ends,': [191], 'transcription': [192], 'initiation': [193, 206], 'occurred': [194], 'at': [195, 300, 312, 377], 'or': [196], 'near': [197], 'point': [199, 293], '89': [200], 'nucleotides': [201, 378], 'upstream': [202], 'translation': [205], 'codon': [207], 'previously': [209], 'reported': [210], 'cDNAs.': [212], 'Once': [213], 'structure': [215], 'had': [220], 'been': [221], 'determined,': [222], 'perform': [227], 'PCR': [229], 'complementary': [232], 'sequences': [235], 'introns': [237], 'flanking': [238], 'each': [239, 441, 445], 'exon': [240, 304, 316, 403, 406], 'encodes': [242], 'enzyme': [243, 388], 'template': [246], 'obtained': [248, 353], 'subjects': [250, 269, 278, 284, 344], 'known': [252], 'phenotypes': [253], 'This': [259], 'blood': [264, 342, 356, 412], 'samples': [265, 338, 357, 366, 385, 391, 413], '4': [267, 276], 'unrelated': [268, 277], 'genetically': [271], 'low': [272, 286, 416], 'high': [280, 346, 368], 'activity.': [282], 'All': [283, 336], 'were': [289, 358, 371, 399], 'homozygous': [290, 415], 'two': [292], 'mutations—': [294], 'G': [296, 310], '→': [297, 309, 329, 333], 'transition': [299, 311], 'nucleotide': [301, 313], '460': [302, 379], '7': [305, 404, 435], 'an': [307], '719': [314], '10.': [317], 'Both': [318], 'mutations': [319, 408, 432], 'resulted': [320, 452], 'alterations': [322], 'amino': [324], 'acid': [325], 'sequence,': [326], 'Ala-154': [328], 'Thr': [330], 'Tyr-240': [332], 'Cys,': [334], 'respectively.': [335], 'contained': [349, 428], '"wild-type"': [350], 'Results': [352], 'confirmed': [359], 'when': [360], 'four': [363], 'liver': [365, 384], 'have': [374], 'wild-type': [375], '719,': [381], 'while': [382], 'three': [383], 'intermediate': [387], '(i.e.,': [390], 'presumed': [392], 'heterozygous': [395, 400], 'polymorphism)': [398], 'present': [409], 'subjects.': [417], 'Transient': [418], 'expression': [419, 425, 455, 510], 'COS-1': [421], 'cells': [422], 'constructs': [426], 'both': [429, 450], '10,': [437], 'as': [438, 440, 447, 449, 472, 474], 'well': [439, 448, 473], 'independently,': [442], 'demonstrated': [443], 'mutation,': [446], 'together,': [451], 'decreased': [454, 509], 'enzymatic': [458], 'protein.': [462], 'Molecular': [463], 'structural': [466], 'characterization': [467], 'elucidation': [475], 'will': [486], 'help': [487], 'make': [488], 'develop': [492], 'DNA-based': [493], 'diagnostic': [494], 'tests': [495], 'mechanism': [503], 'drug-metabolizing': [514], 'enzyme.': [515]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2060310903', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 16}], 'updated_date': '2024-12-11T14:51:32.006727', 'created_date': '2016-06-24'}