A Gain-of-function Mutation in STAT6

Name: Work Video:
Duration: 3 min 30 s
Carla Daniel; Anupama Salvekar; Ulrike Schindler
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3673, 3747, 3814, 3828, 4400], 'amino': [49, 202, 1068, 1097, 1194, 1384, 1435, 1443, 1901, 2133, 2259, 2707, 2790, 3577, 3674, 3815, 3897, 3985, 4054], 'acid': [50, 203, 1195, 1385, 1436, 1444, 1902, 2260, 2708, 2791, 3675, 3816, 3898, 4055], 'changes': [51, 123, 204, 276, 331, 1196, 1386, 2792, 3676, 4056], 'SH2': [54, 207, 762, 1039, 1087, 1199, 1389, 1906, 2087, 2795, 2821, 3582, 4406], 'domain': [55, 208, 319, 1040, 1088, 1907, 2088, 2584, 2796, 3583, 4039, 4407], 'affect': [57, 210, 2137], 'overall': [59, 212], 'structure': [60, 213], 'stability': [62, 215, 2720], 'monomeric': [65, 218, 640, 3028], 'dimeric': [67, 220], 'protein.': [68, 117, 221, 270, 2802, 3639, 3733, 3745], 'When': [69, 222], 'overexpressed': [70, 223], 'mammalian': [72, 225, 1366, 3689], 'cells,': [73, 226, 2175, 2736, 3161, 3269, 3541, 3690], 'undergoes': [75, 228], 'tyrosine': [76, 106, 229, 259, 769, 782, 2323, 2341, 2424, 2554, 2569, 3101, 3648, 3708], 'phosphorylation,': [77, 230, 3649], 'binds': [78, 231, 813, 1214, 2266], 'DNA,': [79, 232, 1215], 'activates': [81, 234, 817, 1217, 2269], 'absence': [85, 238, 1949, 2101, 2237, 2388, 2409, 2567, 2931, 3304, 3340, 3616, 3752, 3799, 4379], 'Using': [89, 242, 2998, 3619], 'Jak1-': [91, 244, 3718], 'Jak3-deficient': [93, 246, 3720], 'fibroblast': [94, 247, 3164], 'line': [95, 248, 3166, 3212, 3484, 3518, 3526, 4958], 'U4A,': [96, 249], 'we': [97, 250, 1173, 1883, 1936, 2153, 2321, 2664, 2717, 2903, 3024, 3150, 3219, 3310, 3346, 3622, 3669], 'demonstrate': [98, 251, 2756, 3555], 'phosphorylation': [100, 253, 2311, 2381, 2425, 2436, 2449, 2578, 2668, 2889, 3102, 3749, 4372], 'by': [103, 256, 386, 606, 771, 1495, 1868, 2397, 2466, 2704, 2725, 3560, 3570, 3705, 3714, 3785, 4150, 4249, 4486, 4856], 'an': [104, 257, 1007, 1031, 1763, 1960, 1992, 2272, 2552, 3706], 'IL-4-independent': [105, 258, 2273, 3707, 3787], 'kinase': [107, 260, 310, 3118, 3562], 'not': [110, 263, 922, 2067, 2217, 2548, 2774, 3093, 3112, 3120, 3249, 3312, 3410, 3546, 3565, 3643, 3653, 3666, 3774, 3821, 3944], 'able': [111, 264, 1989, 2159, 2227, 2493, 2549, 3607, 3723], 'to': [112, 265, 391, 460, 479, 493, 634, 645, 810, 927, 1101, 1122, 1128, 1133, 1233, 1242, 1429, 1456, 1613, 1775, 1797, 1831, 1990, 2044, 2160, 2188, 2228, 2494, 2511, 2550, 2559, 2573, 2683, 2699, 2738, 2744, 2762, 2769, 2905, 2924, 2941, 3051, 3348, 3386, 3567, 3608, 3633, 3685, 3696, 3699, 3724, 3729, 3761, 3808, 3824, 3901, 4059, 4089, 4143, 4245, 4247, 4436, 4735, 4744, 4942], 'activate': [113, 266, 1129, 1991, 2495, 2512, 2563, 3612, 4295], 'wild-type': [115, 268, 1188, 1372, 1503, 2119, 2205, 2368, 2439, 2473, 2782, 2973, 3029, 3062, 3155, 3254, 3373, 3406, 3498, 3638, 3663, 3732, 3744, 3780], 'These': [118, 271, 1001, 1065, 1201, 2125, 2253, 2526, 3073, 3710, 3746, 4365], 'results': [119, 272, 2254, 2754, 2943, 3074, 3711, 3819, 4408], 'suggest': [120, 273, 1003], 'small': [122, 275], 'could': [126, 146, 279, 299, 1140, 1231, 2688, 3243, 3409, 4733, 4931, 4939], 'result': [127, 280], 'hyperactivation': [129, 282, 1224], 'protein': [132, 285, 642, 807, 1208, 1374, 1828, 2111, 2157, 2264, 2331, 2440, 2481, 2975, 2995, 3063, 3408, 3475, 3593, 3664, 3701, 3918, 4001, 4411], 'constitutive': [134, 287, 2149, 3764, 4063], 'STAT6-dependent': [137, 290, 1970, 4747], 'genes.': [138, 291], 'Such': [139, 292], 'mutation,': [141, 294, 2320], 'if': [142, 295, 1227], 'found': [143, 296, 1228, 1329, 4231], 'vivo,': [145, 298, 1230], 'cause': [147, 300], 'genetic': [148, 301, 4432, 4488], 'predisposition': [149, 302], 'for': [150, 303, 936, 1010, 1073, 1092, 1104, 1369, 1760, 1866, 2280, 2535, 2556, 2747, 2781, 2826, 3060, 3095, 3122, 3144, 3278, 3383, 3946, 4051, 4099, 4953, 4970, 4979], 'atopic': [151, 304, 4946], 'interleukin': [306], '4': [307, 3236, 3395], 'T-helper': [308, 396], 'Janus': [309], 'signal': [311], 'transducer': [312], 'activator': [314], 'Src': [317], 'homology': [318], '2': [320, 1603, 2336, 2401, 2503], 'V547A/T548A': [322, 2319, 2544, 2909], 'mutation': [323, 1247, 2342, 2362, 2910, 3895, 4398, 4730, 4936], 'IL-41': [324], 'multifunctional': [327], 'stimulates': [330], 'many': [333, 382, 4431, 4487], 'cell': [334, 3165, 3365, 4154, 4957], 'types': [335], 'involved': [338], 'regulation': [341, 2140], 'immune': [343], 'inflammatory': [345], 'responses': [346, 384], '(1.Paul': [347], 'W.E.': [348, 707, 739], 'Seder': [349], 'R.A.': [350], 'Cell.': [351, 368, 548, 795, 905, 1355, 1522, 1634, 2025, 2297, 2609, 3848, 3875, 3930, 3974, 4019, 4194, 4216], '1994;': [352, 369, 623, 674, 1669, 1725, 2632, 2842, 3202, 3434, 4529], '76:': [353, 370], '241-251Abstract': [354], 'Full': [355, 372, 696, 714, 716, 744, 746, 829, 831, 1055, 1057, 1160, 1162, 1409, 1411, 1478, 1480, 1546, 1548, 1816, 1922, 1924, 2654, 2864, 2958, 3016, 4170, 4172, 4280, 4282, 4883, 4885], 'Text': [356, 373, 697, 715, 717, 745, 747, 830, 832, 1056, 1058, 1161, 1163, 1410, 1412, 1479, 1481, 1547, 1549, 1817, 1923, 1925, 2655, 2865, 2959, 3017, 4171, 4173, 4281, 4283, 4884, 4886], 'PDF': [357, 374, 698, 718, 748, 833, 1059, 1164, 1413, 1482, 1550, 1818, 1926, 2656, 2866, 2960, 3018, 4174, 4284, 4887], 'PubMed': [358, 375, 416, 431, 446, 471, 532, 553, 586, 598, 626, 677, 699, 719, 749, 800, 834, 846, 889, 910, 953, 969, 996, 1060, 1165, 1360, 1414, 1483, 1527, 1551, 1639, 1672, 1693, 1728, 1749, 1819, 1927, 2030, 2302, 2614, 2635, 2657, 2845, 2867, 2961, 3019, 3189, 3205, 3437, 3468, 3853, 3880, 3935, 3979, 4024, 4133, 4175, 4199, 4221, 4285, 4309, 4326, 4360, 4468, 4532, 4587, 4631, 4654, 4755, 4774, 4790, 4817, 4844, 4869, 4888, 4924], 'Scopus': [359, 376, 417, 432, 447, 533, 554, 587, 599, 627, 678, 700, 720, 750, 801, 835, 847, 890, 911, 954, 970, 997, 1061, 1166, 1361, 1415, 1484, 1528, 1552, 1640, 1673, 1694, 1729, 1750, 1820, 1928, 2031, 2303, 2615, 2636, 2658, 2846, 2868, 2962, 3020, 3190, 3206, 3438, 3469, 3854, 3881, 3936, 3980, 4025, 4134, 4176, 4200, 4222, 4286, 4310, 4327, 4361, 4469, 4533, 4588, 4632, 4655, 4756, 4775, 4791, 4818, 4845, 4870, 4889, 4925], '(1700)': [360], 'Google': [361, 378, 419, 434, 449, 472, 535, 556, 573, 589, 601, 629, 680, 702, 722, 752, 803, 837, 849, 862, 892, 913, 956, 972, 999, 1063, 1168, 1363, 1417, 1486, 1530, 1554, 1642, 1675, 1696, 1731, 1752, 1822, 1930, 2033, 2305, 2617, 2638, 2660, 2848, 2870, 2964, 3022, 3192, 3208, 3440, 3471, 3856, 3883, 3938, 3982, 4027, 4136, 4178, 4202, 4224, 4288, 4312, 4329, 4363, 4471, 4535, 4590, 4612, 4634, 4657, 4670, 4707, 4726, 4758, 4777, 4793, 4820, 4847, 4872, 4891, 4927], 'Scholar,2.Kishimoto': [362], 'T.': [363, 365, 538, 785, 852, 895, 959, 977, 979, 1042, 1147, 1345, 1396, 1465, 1512, 1533, 1624, 1909, 2015, 2287, 2599, 3861, 3873, 3964, 4005, 4017, 4183, 4639, 4662, 4687, 4689, 4697, 4780, 4798, 4800, 4823, 4833], 'Taga': [364], 'Akira': [366, 986, 4807, 4836], 'S.': [367, 523, 592, 880, 975, 987, 1680, 1688, 1736, 1744, 3184, 3463, 4442, 4570, 4597, 4637, 4691, 4749, 4796, 4808, 4837, 4913], '253-262Abstract': [371], '(1250)': [377], 'Scholar).': [379, 450, 473, 602, 630, 753, 804, 863, 914, 1000, 1064, 1169, 1364, 1418, 1487, 1555, 1643, 1697, 1753, 1823, 1931, 2034, 2306, 2661, 2871, 3209, 3472, 3884, 3939, 3983, 4028, 4137, 4225, 4289, 4330, 4364, 4472, 4536, 4727, 4928], 'Among': [380], 'physiological': [383], 'its': [389, 635, 2574, 2684, 2888, 3595], 'ability': [390, 3385], 'promote': [392], 'differentiation': [394], '(Th)': [397], 'precursors': [398], 'toward': [399], 'Th2': [401], 'lineage': [402], 'while': [403], 'inhibiting': [404], 'Th1': [405], 'development': [406, 4499], '(3.Mosmann': [407], 'T.R.': [408, 422], 'Coffman': [409, 423], 'R.L.': [410, 424], 'Adv.': [411, 466, 4862], 'Immunol.': [412, 427, 467, 569, 858, 4703, 4722, 4878], '1989;': [413, 428, 1690, 1746], '46:': [414], '111-147Crossref': [415], '(1027)': [418], 'Scholar,': [420, 435, 536, 557, 574, 590, 681, 703, 723, 838, 850, 893, 957, 973, 1531, 1676, 1732, 2618, 2639, 2849, 3193, 3441, 3857, 4179, 4203, 4313, 4591, 4613, 4635, 4658, 4671, 4708, 4759, 4778, 4794, 4821, 4873], '4.Mosmann': [421], 'Annu.': [425, 580], 'Rev.': [426, 581], '7:': [429, 827], '145-173Crossref': [430], '(6879)': [433], '5.Abbas': [436], 'A.K.': [437], 'Murphy': [438], 'K.M.': [439], 'Sher': [440], 'A.': [441, 729, 1689, 1745, 3185, 3464, 4120, 4261, 4302, 4444, 4448, 4566, 4599, 4685], 'Nature.': [442, 4464], '1996;': [443, 468, 550, 711, 741, 797, 907, 1357, 1524, 1636, 2027, 2299, 2611, 3850, 3932, 3976, 4323, 4465, 4866, 4921], '383:': [444, 4466], '787-793Crossref': [445], '(3887)': [448], 'Furthermore,': [451, 1116, 3490, 3734, 3908, 4226, 4473], 'stimulation': [453, 521, 2104, 2213, 2353, 2393, 2430, 3480], 'B-cells': [455, 915], 'triggers': [456, 2576], 'immunoglobulin': [457], 'class': [458], 'switching': [459], 'IgE': [462, 924, 1235, 4559, 4740, 4858], 'isotype': [463], '(6.Stavnezer': [464], 'J.': [465, 525, 526, 568, 611, 662, 857, 882, 883, 947, 1049, 1154, 1403, 1472, 1540, 1657, 1713, 1916, 2620, 2830, 3170, 3844, 3926, 4164, 4181, 4259, 4320, 4354, 4568, 4580, 4603, 4605, 4606, 4626, 4645, 4647, 4664, 4702, 4714, 4721, 4768, 4838], '61:': [469], '79-146Crossref': [470], 'This': [474, 754, 1223, 2784, 3640, 3803], 'Ig': [475], 'recombination': [476], 'thought': [478, 4244], 'be': [480, 1102, 1240, 2208, 2897, 3244, 3411, 3568, 3794, 3806, 4144], 'initiated': [481], 'following': [482, 2452], 'transcriptional': [484, 2873, 3079], 'germline': [488, 876, 1333, 1978], 'ε': [489, 499, 511, 877, 1334, 1979], 'promoter,': [490], 'which': [491, 1021, 2591, 2823, 3133], 'leads': [492], 'generation': [495], 'sterile': [498], 'transcript.': [500], 'Numerous': [501], 'studies': [502, 1066, 1700, 2191, 2527, 3149, 3402, 3772], 'have': [503, 1174, 1391, 1507, 1619, 1708, 1937, 2665, 3574, 3838, 3987, 4384], 'shown': [504, 1100, 3892, 4142], 'promoter': [512, 878, 1579, 1995], 'requires': [513, 756], 'STAT6,': [514, 1226, 1985, 2000], 'upon': [519, 1996, 2211, 2428, 2899, 2914, 3293, 3478], '(7.Delphin': [522, 879], 'Stavnezer': [524, 881], 'Exp.': [527, 884, 948, 991, 4321, 4582, 4769, 4812, 4839, 4863], 'Med.': [528, 885, 949, 4322, 4607, 4627, 4666, 4770, 4840, 4864], '1995;': [529, 583, 693, 886, 1813, 2651, 2861, 2955, 3013, 4130, 4306], '181:': [530, 887], '181-192Crossref': [531, 888], '(189)': [534, 891], '8.Mikita': [537, 894], 'Campbell': [539, 786, 896, 1346, 1513, 1625, 2016, 2288, 2600, 3965], 'D.': [540, 787, 897, 940, 1347, 1514, 1626, 2017, 2289, 2601, 3172, 3867, 3966, 4011, 4209, 4347, 4761], 'Wu': [541, 684, 788, 898, 1045, 1150, 1348, 1399, 1468, 1515, 1536, 1627, 1804, 1912, 2018, 2290, 2602, 2642, 2852, 2946, 3004, 3444, 3967], 'P.': [542, 685, 735, 789, 899, 1046, 1151, 1349, 1400, 1469, 1516, 1537, 1628, 1805, 1913, 2019, 2291, 2603, 2643, 2853, 2947, 3005, 3968], 'Williamson': [543, 790, 900, 1350, 1517, 1629, 2020, 2292, 2604, 3969], 'K.': [544, 737, 791, 901, 983, 985, 1351, 1518, 1630, 2021, 2293, 2605, 3449, 3842, 3863, 3924, 3970, 4007, 4660, 4683, 4701, 4804, 4806, 4835], 'Schindler': [545, 612, 663, 792, 855, 902, 960, 1047, 1152, 1352, 1401, 1470, 1519, 1538, 1631, 1658, 1714, 1914, 2022, 2294, 2606, 2621, 2831, 3971, 4781], 'U.': [546, 613, 664, 683, 793, 856, 903, 961, 1048, 1153, 1353, 1402, 1471, 1520, 1539, 1632, 1659, 1687, 1715, 1743, 1803, 1915, 2023, 2295, 2607, 2622, 2641, 2832, 2851, 2945, 3003, 3183, 3462, 3972, 4782], 'Mol.': [547, 794, 904, 1354, 1521, 1633, 2024, 2296, 2608, 3847, 3874, 3929, 3973, 4018, 4193, 4215, 4665], 'Biol.': [549, 796, 906, 1050, 1155, 1356, 1404, 1473, 1523, 1541, 1635, 1917, 2026, 2298, 2610, 3849, 3876, 3931, 3975, 4020, 4165, 4195, 4217, 4865], '16:': [551, 798, 908, 1358, 1525, 1637, 2028, 2300, 2612, 3851, 3933, 3977], '5811-5820Crossref': [552, 799, 909, 1359, 1526, 1638, 2029, 2301, 2613, 3978], '(229)': [555, 802, 912, 1362, 1529, 1641, 2032, 2304, 2616, 3191, 3981], '9.Linehan': [558], 'L.A.': [559, 4619], 'Warren': [560], 'W.D.': [561], 'Thompson': [562], 'P.A.': [563], 'Grusby': [564, 945, 4766], 'M.J.': [565, 946, 4353, 4767], 'Berton': [566], 'M.T.': [567], '1998;': [570, 859, 950, 966, 1052, 1157, 1406, 1475, 1543, 1919, 3877, 4021, 4196, 4218, 4584, 4771, 4787, 4841, 4880], '161:': [571, 860], '302-310PubMed': [572], '10.Schindler': [575], 'C.': [576, 1044, 1149, 1398, 1467, 1535, 1911, 4163, 4523, 4572, 4903], 'Darnell': [577, 4212], 'Jr.,': [578, 840, 3195, 3427, 4213], 'J.E.': [579, 841, 3196, 3428, 4214], 'Biochem.': [582], '64:': [584], '621-651Crossref': [585], '(1657)': [588], '11.Akira': [591], 'Stem': [593, 4750], 'Cells.': [594, 4751], '1999;': [595, 993, 4277, 4357, 4609, 4651, 4667, 4704, 4723, 4752, 4814], '17:': [596, 4753], '138-146Crossref': [597, 4754], '(276)': [600, 4757], 'Jak/STAT': [608, 4297], 'pathway': [609, 4298], '(12.Hou': [610, 661, 1656, 1712, 2829], 'Henzel': [614, 665, 1660, 1716, 2623, 2833], 'W.J.': [615, 666, 1661, 1717, 2624, 2834, 4128], 'Ho': [616, 667, 1662, 1718, 2625, 2835], 'T.Z.': [617, 668, 1663, 1719, 2626, 2836], 'Brasseur': [618, 669, 688, 1664, 1720, 1808, 2627, 2646, 2837, 2856, 2950, 3008], 'M.': [619, 670, 687, 689, 854, 944, 989, 1665, 1721, 1807, 1809, 2628, 2645, 2647, 2838, 2855, 2857, 2949, 2951, 3007, 3009, 3174, 3859, 3869, 4003, 4013, 4349, 4578, 4641, 4693, 4765, 4810, 4827], 'McKnight': [620, 671, 690, 1666, 1722, 1810, 2629, 2648, 2839, 2858, 2952, 3010], 'S.L.': [621, 672, 691, 1667, 1723, 1811, 2630, 2649, 2840, 2859, 2953, 3011], 'Science.': [622, 673, 842, 1668, 1724, 2631, 2841, 3201, 3433, 4129, 4305, 4528], '265:': [624, 675, 1670, 1726, 2633, 2843], '1701-1706Crossref': [625, 676, 1671, 1727, 2634, 2844], '(730)': [628, 679, 1674, 1730, 2637, 2847], 'Upon': [631], 'binding': [633, 1105, 1616, 1699, 2190, 2202, 2245, 2285, 2345, 2419, 2572, 2682, 2815, 2893, 2926, 2970, 2990, 3352, 3392, 3758, 4038], 'cognate': [636], 'receptor,': [637, 652], 'latent,': [639], 'recruited': [644], 'α': [647, 2589, 2810, 3140, 4552], 'chain': [648, 1427, 2811, 4553], 'where': [653], 'it': [654, 1191, 1211, 1238, 3057, 3681, 3890, 4066], 'specifically': [655], 'interacts': [656], 'with': [657, 1025, 1081, 1271, 1295, 1589, 1762, 1959, 2325, 2416, 2695, 2819, 3036, 3136, 3369, 3388, 3399, 3661, 3768, 4239, 4556], 'phosphotyrosine-containing': [659], 'regions': [660], '13.Schindler': [682, 2640, 2850], 'Rothe': [686, 1806, 2644, 2854, 2948, 3006], 'Immunity.': [692, 710, 740, 825, 1812, 2650, 2860, 2954, 3012, 4276], '2:': [694, 1814, 2652, 2862, 2956, 3014], '689-697Abstract': [695, 1815, 2653, 2863, 2957, 3015], '(233)': [701, 1821, 2659, 2869, 2963, 3021, 4656], '14.Wang': [704], 'H.Y.': [705, 4710], 'Paul': [706, 738], 'Keegan': [708, 728, 4719], 'A.D.': [709, 4720], '4:': [712, 742], '113-121Abstract': [713], '(76)': [721], '15.Ryan': [724], 'J.J.': [725, 824, 4124, 4718], 'McReynolds': [726], 'L.J.': [727], 'Wang': [730], 'L.-H.': [731], 'Garfein': [732], 'E.': [733, 4187, 4521, 4574, 4915], 'Rothman': [734, 4303], 'Nelms': [736], '123-132Abstract': [743], '(140)': [751], 'interaction': [755], 'integrity': [758], 'domain.': [763, 1200, 4049], 'Subsequently,': [764], 'becomes': [766, 1212], 'phosphorylated': [767, 3559, 3655, 3704, 3784, 3922, 4078], 'on': [768, 2988, 3957, 4388], '641': [770, 2324], 'Jak1': [772, 3274, 3342, 3421, 3492, 3530], 'and/or': [773, 1255], 'Jak3,': [774, 3114], 'members': [776], 'Jak': [779], 'family': [780], 'kinases': [783], '(8.Mikita': [784, 1344, 1511, 1623, 2014, 2286, 2598, 3963], 'The': [805, 1276, 1313, 1365, 1419, 1447, 1488, 1499, 1585, 1754, 1767, 1839, 1952, 2753, 2872, 3045, 3086, 3210], 'dimerizes,': [808], 'migrates': [809], 'nucleus,': [812], 'specificcis-acting': [814], 'elements,': [815], 'responsive': [821, 870, 1994], 'genes': [822], "(16.O'Shea": [823], '1997;': [826, 843, 3465, 4167, 4628], '1-11Abstract': [828], '(345)': [836], '17.Darnell': [839], '277:': [844], '1630-1635Crossref': [845], '(3400)': [848], '18.Mikita': [851], 'Kurama': [853], '1822-1828PubMed': [861], 'One': [864, 4029], 'best': [867], 'characterized': [868, 1175, 3151, 4855], 'elements': [871], 'located': [873, 4044], 'derived': [916, 1109, 1974, 2805], 'from': [917, 1110, 1186, 1252, 1283, 1308, 1892, 1975, 2181, 2806, 3594, 4237, 4343], 'knock-out': [919], 'mice': [920], 'do': [921, 3111, 3311, 3773, 3820], 'produce': [923], 'response': [926, 1132, 1325, 1972, 2195, 2232, 4743], 'treatment,': [929], 'illustrating': [930], 'absolutely': [934, 2533, 3107, 3276], 'required': [935, 1091, 2313, 2672, 2825, 3094, 3143, 4058], 'this': [937, 1171, 1338, 2003, 2110, 2676, 3034, 3117, 3600, 3691, 3786, 3790], 'event': [938, 2677], '(19.Kuperman': [939], 'Schofield': [941, 4762], 'B.': [942, 4517, 4595, 4763, 4909], 'Wills-Karp': [943, 4764], '187:': [951, 4772, 4842], '939-948Crossref': [952, 4773], '(406)': [955, 4776], '20.Hoey': [958, 4779], 'Curr.': [962, 4783], 'Opin.': [963, 4784], 'Genet.': [964, 4608, 4785], 'Dev.': [965, 4786], '8:': [967, 4788], '582-587Crossref': [968, 4789], '(86)': [971, 4177, 4792], '21.Miyata': [974, 4795], 'Matsuyama': [976, 4797], 'Kodama': [978, 4799], 'Nishioka': [980, 4801], 'Y.': [981, 4675, 4681, 4802, 4829], 'Kuribayashi': [982, 4803], 'Takeda': [984, 4805, 4834], 'Sugita': [988, 4809], 'Clin.': [990, 4355, 4581, 4811], 'Allergy.': [992, 4583, 4813], '29:': [994, 4815], '114-123Crossref': [995, 4816], '(68)': [998, 4819], 'observations': [1002, 4366], 'excellent': [1008], 'target': [1009], 'therapeutic': [1011], 'intervention': [1012], 'cases': [1014], 'rhinitis': [1017, 1254, 4509, 4851], 'asthma,': [1020], 'are': [1022, 1071, 1988, 3712, 3722, 4076, 4108, 4479, 4484, 4554, 4854], 'often': [1023], 'associated': [1024, 3135, 4555], 'hyper-IgE': [1026], 'production.': [1027, 1236], 'recently': [1029], 'conducted': [1030], 'extensive': [1032], 'alanine': [1033, 1432], 'scan': [1034], 'mutagenesis': [1035], '(22.Mikita': [1041, 1146, 1395, 1464, 1908], 'Daniel': [1043, 1148, 1397, 1466, 1534, 1910], 'Chem.': [1051, 1156, 1405, 1474, 1542, 1918, 4166], '273:': [1053, 1158, 1407, 1476, 1544, 1920], '17634-17642Abstract': [1054, 1159, 1408, 1477, 1545, 1921], '(48)': [1062, 1167, 1416, 1485, 1553, 1929], 'revealed': [1067], 'acids': [1069, 1098, 2134, 3578, 3986], 'critical': [1072, 2279, 4495, 4972], 'dimer': [1074, 2827, 2913, 3055, 3069], 'formation': [1075, 2828], 'subsequent': [1077], 'DNA': [1078, 1124, 1142, 1496, 2046, 2164, 2189, 2201, 2267, 2284, 2333, 2344, 2418, 2561, 2814, 2892, 2915, 2925, 2969, 2989, 3351, 3391, 3610, 3757, 4037], 'binding.': [1079, 2334, 2916], 'Consistent': [1080, 2415], 'model': [1083], 'STAT': [1086, 4073, 4094, 4375], 'also': [1090, 1126, 1508, 2047, 2378, 2487, 2674, 3783, 4140, 4975], 'receptor': [1093, 1113, 1705, 2575, 2588, 2809, 2934, 3090, 3139, 4551], 'interaction,': [1094], 'same': [1096, 1755, 2879, 3038], 'were': [1099, 1120, 1125, 1143, 1260, 1287, 1560, 1587, 1601, 1646, 1652, 1758, 1790, 1829, 1861, 1954, 2042, 2057, 2066, 2171, 2179, 2492, 2509, 2523, 2732, 2922, 3367, 3379, 4057], 'important': [1103], 'tyrosine-phosphorylated': [1107, 1703, 2406, 2933, 3604], 'peptide': [1108, 2935, 2967, 2984, 3035], 'signaling': [1114, 2012], 'chain.': [1115], 'mutants': [1118, 1179, 1889, 1944], 'unable': [1121, 1127, 2510, 3807], 'bind': [1123, 1141, 2045, 2163, 2229, 2560, 3609], 'stimulation,': [1135], 'whereas': [1136, 2447], 'derivatives': [1138, 2040], 'transcriptionally': [1144, 2096], 'active': [1145, 2058, 2068, 2097, 2117, 3318, 3336, 3477, 3513, 3832, 3999, 4110, 4228, 4334, 4415], 'In': [1170, 1932, 2108, 2223, 2433, 2518, 2939, 3147, 3281, 3397, 3509, 3688, 3789, 3885], 'study': [1172], 'one': [1176, 2053, 2687, 4930], 'these': [1178, 1943, 2131, 2384, 2490, 3148, 3552, 3771, 3827, 4031], '(STAT6VT)': [1180], 'greater': [1182], 'detail.': [1183], 'differs': [1185], 'mutations': [1202, 1452, 1492, 2129, 4070], 'alter': [1203, 2797], 'confirmation': [1205], 'such': [1209, 1245], 'phosphorylated,': [1213], 'independent': [1219, 2679, 3527], 'lead': [1232, 4734], 'increased': [1234, 2898, 3256, 3756, 4857], 'Hence,': [1237, 2686, 2902, 3668, 4065, 4929], 'will': [1239], 'interesting': [1241], 'see': [1243], 'whether': [1244, 2155, 2309, 2489, 2907, 3128, 3529], 'occurs': [1248], 'patients': [1250, 4238, 4941], 'suffering': [1251], 'asthma.': [1257], 'HEK293': [1258, 1556, 1957, 1981, 2174, 2500, 2920, 3109, 3540], 'cells': [1259, 1280, 1559, 1586, 1794, 1958, 1982, 2185, 2501, 2921, 3083, 3110, 3292, 3321, 3415, 3504, 3629, 3658, 3721, 4236, 4342], 'cultured': [1261, 1288], "Dulbecco's": [1263, 1290], 'modified': [1264, 1291], "Eagle's": [1265, 1292], 'medium/F12': [1266], '(Meditech,': [1267], 'Herndon,': [1268], 'VA)': [1269], 'supplemented': [1270, 1294], '10%': [1272, 1296], 'fetal': [1273, 1297], 'bovine': [1274, 1298], 'serum.': [1275, 1299], 'human': [1277, 1332, 1977], 'fibrosarcoma': [1278], 'U4A': [1279, 1558, 3160, 3233, 3268, 3291, 3320, 3360, 3414, 3503, 3525, 4956], '(a': [1281], 'gift': [1282], 'Dr.': [1284, 4950], 'George': [1285, 4951], 'Stark)': [1286], 'medium': [1293], 'Human': [1300], '(4.1': [1302], '×': [1303], '107': [1304], 'unit/mg)': [1305], 'was': [1306, 1423, 1453, 1493, 1580, 1770, 1841, 1878, 2095, 2112, 2226, 2246, 2369, 2426, 2441, 2450, 2459, 2464, 3286, 3300, 3315, 3476, 3493, 3500, 3512, 3531, 3891, 3920], 'purchased': [1307], 'R&D': [1309], 'Systems': [1310], '(Minneapolis,': [1311], 'MN).': [1312], 'inducible': [1315, 1962], 'luciferase': [1316, 1963, 3241, 3284], 'reporter': [1317, 1964], 'construct': [1318, 1339], 'four': [1320, 1966], 'copies': [1321, 1967], 'element': [1326, 1973, 2233, 3393], '(C/EBP-N4': [1327], 'site)': [1328], 'promoter.': [1335, 1980], 'Preparation': [1336], 'has': [1340, 3954, 4096, 4139, 4336], 'been': [1341, 1392, 1509, 1620, 1709, 3839, 3988, 4097, 4141, 4337], 'described': [1342, 1393, 1510, 1621, 1655, 1710, 1800, 4098], 'previously': [1343, 1622, 1801], 'plasmids': [1368], 'Jak1,': [1370, 3132], 'as': [1375, 1377, 1654, 1799, 2371, 3056, 3215, 3520, 3522, 4475, 4477, 4543, 4545], 'well': [1376, 3521, 4476, 4544], 'derivatives,': [1381], 'carrying': [1382, 1572, 1965, 2359], 'domain,': [1390, 2822], 'elsewhere': [1394, 1711], 'triple': [1420], 'STAT6VT/Y': [1422, 2508], 'prepared': [1424, 2180, 3380], 'using': [1425, 1562, 1606, 1701, 1779, 2192, 2332, 2394], 'polymerase': [1426], 'reaction': [1428, 1840], 'introduce': [1430], 'residues': [1433, 2077, 4402], 'at': [1434, 1442, 1843, 2078, 3103], 'positions': [1437, 2079], '547/548': [1438], 'phenylalanine': [1441, 2326, 2467], 'position': [1445], '641.': [1446], 'fragment': [1448, 1460], 'containing': [1449], 'indicated': [1451], 'then': [1454], 'used': [1455, 1759, 2370], 'replace': [1457], 'BglII/SacI': [1459], 'TPU': [1462], '389': [1463], 'presence': [1489, 1947, 2062, 2350, 2390, 2929], 'confirmed': [1494], 'sequence': [1497], 'analysis.': [1498], 'baculovirus': [1500], 'plasmids,': [1502], 'STAT6VT,': [1506, 2152, 3602, 4052], '22.Mikita': [1532], 'or': [1557, 2169, 2183, 2478, 2562, 2930, 3361, 3375, 4083, 4852], 'transfected': [1561, 3368], 'calcium': [1563], 'phosphate': [1564], 'precipitation': [1565], '(Promega,': [1566], 'Madison,': [1567], 'WI).': [1568], 'A': [1569, 2337, 3237, 3871, 3940, 4015, 4728], 'control': [1570, 1877, 2372], 'plasmid': [1571], 'β-galactosidase': [1574, 1599], 'under': [1576, 2218], 'cytomegalovirus': [1578], 'co-transfected': [1581, 3532], 'each': [1583, 1827, 1873], 'experiment.': [1584], 'stimulated': [1588], '(10': [1591], 'ng/ml)': [1592], '6': [1593, 3534], 'h': [1594], 'before': [1595], 'harvesting.': [1596], 'Luciferase': [1597], 'activities': [1600], 'determined': [1602, 3127], 'days': [1604], 'post-transfection': [1605], 'Promega': [1608], 'assay': [1609], 'system.': [1610], 'Probes': [1611], 'corresponding': [1612], 'site': [1617], '(N4)': [1618], 'Nuclear': [1644, 3377], 'extracts': [1645, 1757, 2178, 3378], 'prepared,': [1647], 'mobility': [1649], 'shift': [1650], 'assays': [1651], 'performed': [1653, 1879], '24.Osborn': [1677, 1733], 'L.': [1678, 1734, 4267], 'Kunkel': [1679, 1735], 'Nable': [1681, 1737], 'G.J.': [1682, 1738], 'Proc.': [1683, 1739, 3179, 3458], 'Natl.': [1684, 1740, 3180, 3459], 'Acad.': [1685, 1741, 3181, 3460], 'Sci.': [1686, 1742, 3182, 3461], '86:': [1691, 1747], '2336-2340Crossref': [1692, 1748], '(1373)': [1695, 1751], 'Peptide': [1698], 'peptide,': [1706], 'ASSGEEGPY*KPFQDLI,': [1707], 'nuclear': [1756, 2177], 'immunoprecipitations': [1761, 2395], 'anti-STAT6-specific': [1764], 'polyclonal': [1765], 'antibody.': [1766], 'precipitated': [1768], 'material': [1769], 'electrophoretically': [1771], 'separated': [1772], 'subjected': [1774, 2187, 2923], 'anti-phosphotyrosine': [1776, 2398], 'Western': [1777], 'blots': [1778], '4G10': [1781], 'monoclonal': [1782], 'anitbody': [1783], '(Upstate': [1784], 'Biotechnology).': [1785], 'Wild-type': [1786], 'expressed': [1791, 2172, 2498, 2733, 2918, 3358, 3626], 'insect': [1793, 2735, 3628, 3657], 'purified': [1796, 2737], 'homogeneity': [1798, 2739], '(13.Schindler': [1802, 2944, 3002], '30': [1824], 'μg': [1825, 1833], 'exposed': [1830, 2743], '3': [1832, 2374, 2475, 2937], 'trypsin': [1836, 2745], '(Sigma)': [1837], 'protease.': [1838, 1881], 'incubated': [1842], '37': [1844], '°C': [1845], '1×': [1847], 'digestion': [1848, 2778, 3635], 'buffer': [1849], '(20': [1850], 'mm': [1851, 1856], 'Tris,': [1852], 'pH': [1853], '7.2,': [1854], '1': [1855], 'dithiothreitol).': [1857], '10': [1858], 'μl': [1859], 'aliquots': [1860], 'removed': [1862], 'every': [1863], '20': [1864], 'min': [1865], 'analysis': [1867], 'SDS-polyacrylamide': [1869], 'gel': [1870], 'electrophoresis.': [1871], 'For': [1872, 3308, 4103], 'reaction,': [1874], 'negative': [1876], 'without': [1880, 2069, 2165], 'Previously,': [1882], 'generated': [1884], 'series': [1886], 'differ': [1891], 'wild': [1894], 'type': [1895], 'they': [1898, 1987, 2817, 4483], 'carry': [1899], 'substitutions': [1903], 'present': [1934], 'study,': [1935], 'compared': [1938, 2718, 3220, 3660], 'potential': [1941, 3829], 'cytokine.': [1951], 'proteins': [1953, 2056, 2385, 2491, 2731, 3032, 3356, 4074, 4095], 'co-expressed': [1955], 'lack': [1983, 3419], 'endogenous': [1984], 'but': [1986, 2216, 2673, 3248, 3263, 3727], 'ectopic': [1997], 'suggesting': [2001], 'only': [2006, 2059, 2210], 'component': [2007], 'missing': [2008], 'IL-4/STAT6': [2011], 'cascade': [2013], 'As': [2035, 3537], 'observed': [2036, 2247, 3287, 3538, 4060, 4338], 'previously,': [2037], 'all': [2038, 2055], 'known': [2043], '(Fig.': [2050, 2502, 2936, 3084, 3394], '1).': [2051, 2107, 2222, 3085], 'With': [2052], 'exception,': [2054], 'Strikingly,': [2072, 3599], 'substitution': [2074, 2261], '547': [2080], '(V)': [2081], '548': [2083], '(T)': [2084], 'resulted': [2089, 3915], 'even': [2098, 2234, 2347, 2514, 2538, 2886, 3316, 3337], '(VT,': [2105], 'Fig.': [2106, 2335, 2400, 3235], 'addition,': [2109], 'about': [2113, 3261], 'three': [2114], 'times': [2115], 'more': [2116, 2760, 3071, 3317, 3631, 3738], 'than': [2118, 3322, 3636, 3742], 'induced': [2123, 2882], 'state.': [2124], 'data': [2126, 3087, 3330], 'suggested': [2127], '(VT)': [2135], 'dramatically': [2136], 'IL-4-dependent': [2139], 'To': [2143, 2307, 2710], 'explore': [2144, 2308], 'mechanism': [2146, 3942], 'underlying': [2147], 'activity': [2150, 2203, 2346, 2874, 2894, 3080, 3242, 3258, 3285, 3353, 3589, 3766], 'asked': [2154, 2488], 'dimerize': [2161], 'IL-4-treated': [2182], 'untreated': [2184], 'element.': [2196], 'Fig.2': [2197], 'shows': [2198, 2338, 3238, 3331], 'can': [2207, 2895, 4071, 4294, 4383], 'seen': [2209, 2427, 2442, 2451, 2694, 3059, 3301, 3767], '(lane': [2214, 2221, 2240, 2251, 2413, 2431, 2740], '2),': [2215], 'unstimulated': [2219, 3082], 'conditions': [2220], 'contrast,': [2224, 2434, 2519, 3282, 3510], '5).': [2241, 2414], 'Some': [2242], 'increase': [2243, 2422], 'after': [2248, 2515, 2766], 'treatment': [2250, 2412, 2454], '6).': [2252, 2432], 'show': [2255, 2529, 3623], 'double': [2258], 'yields': [2262], 'manner.': [2274], 'Phosphorylation': [2275, 2458], 'Tyr-641': [2277, 2310, 2361, 2463, 2531, 3105], 'dimerization': [2282, 2557], 'context': [2316, 2365, 2470, 2541], 'substituted': [2322], '(STAT6VT/Y)': [2327], 'analyzed': [2329], 'abolished': [2343, 2461], '(lanes': [2354, 2373, 2455, 2474, 2482, 2751, 2980, 2996, 3533], '7': [2355, 2483], '8).': [2357, 2485], 'STAT6Y': [2358, 2506], '4).': [2376, 3489], 'investigated': [2379], 'status': [2382, 2890, 4390], 'followed': [2396], 'immunoblotting.': [2399], 'Bshows': [2402], 'studies,': [2420], 'some': [2421, 4100], 'no': [2435, 2986, 3265, 3955], 'uninduced': [2445, 2884], 'state,': [2446], 'strong': [2448, 3283], '1and': [2456], '2).': [2457], 'completely': [2460], 'when': [2462, 2497, 3357, 3491, 3585, 3659, 3993], 'replaced': [2465], '4)': [2477, 3425], 'C).': [2504], 'Both': [2505, 3364], 'fully': [2524], 'active.': [2525], 'clearly': [2528, 2755, 3554], 'essential': [2534, 3277], 'function': [2537, 3130], 'mutation.': [2545], 'utilize': [2551], 'alternative': [2553], 'residue': [2555, 3104], 'nor': [2558], 'phosphorylation.': [2570, 3124], 'tyrosines': [2580], 'intracellular': [2583], 'chain,': [2590, 3141], 'allow': [2592, 3822], 'specific': [2594], 'recruitment': [2595], '12.Hou': [2619], 'So': [2662], 'far,': [2663], 'demonstrated': [2666, 3025], 'receptor.': [2685], 'argue': [2689, 3670], 'gain-of-function': [2692, 4729, 4935], 'phenotype': [2693], 'due': [2698], 'structural': [2701], 'change': [2702, 3692], 'substitutions.': [2709], 'address': [2711], 'possibility': [2713, 3778], 'conformational': [2715], 'change,': [2716], 'limited': [2726, 3620], 'proteolysis': [2727], '(Fig.3': [2728], 'A).': [2729], 'Recombinant': [2730], '1),': [2741], 'protease': [2746, 2763, 3634, 3686], 'increasing': [2748], 'incubation': [2749], 'periods': [2750], '2-9).': [2752], 'resistant': [2761, 3632], 'digestion.': [2764, 3687], 'Even': [2765], 'prolonged': [2767], 'exposure': [2768], 'protease,': [2771], 'did': [2773, 3545], 'generate': [2775], 'complex': [2777, 3741], 'pattern': [2779], 'obtained': [2780], 'finding': [2785, 4395], 'suggests': [2786, 3065], 'conformation': [2799, 3694], 'Tyrosine-phosphorylated': [2803], 'peptides': [2804, 3050], 'inhibit': [2812], 'because': [2816, 3416, 3650, 3811, 3948, 4739], 'interact': [2818], 'state': [2885], 'though': [2887], 'still': [2896], 'wished': [2904, 3347], 'determine': [2906, 3349], 'stabilizes': [2911], 'Proteins': [2917], 'B).': [2938, 3396], 'agreement': [2940, 3398], 'previous': [2942], 'Scholar),': [2965], 'inhibited': [2968], 'dose-dependent': [2978], 'manner': [2979, 4082, 4149], '2-4).': [2981], 'Interestingly,': [2982], 'had': [2985, 3264], 'effect': [2987, 3266, 3956, 4387], '7-9).': [2997], 'fluorescence': [2999], 'polarization': [3000], 'experiments': [3001], 'Scholar)': [3023, 4848], 'bound': [3033], 'affinity': [3039], '(K': [3040], 'd': [3041], '∼': [3042], '0.3': [3043], 'μm).': [3044], 'failure': [3046], 'receptor-derived': [3049], 'displace': [3052], 'strongly': [3064], 'stable.': [3072], 'help': [3075, 3760], 'explain': [3076, 3762], 'high': [3078], 'indicate': [3088], 'ligation': [3091], 'STAT6VT.': [3099, 3296, 3376, 3769], 'However,': [3100, 3328, 3473], 'essential.': [3108], 'express': [3113], 'demonstrating': [3115], 'necessary': [3121], 'next': [3126], 'activation.': [3146], 'behavior': [3153], 'Jak1-deficient': [3163], '(25.McKendry': [3167], 'R.': [3168, 4161, 4185, 4192, 4253, 4263, 4275, 4911], 'John': [3169], 'Flavell': [3171], 'Muller': [3173], 'Kerr': [3175, 3197, 3429, 3452], 'I.M.': [3176, 3198, 3430, 3453], 'Stark': [3177, 3199, 3431, 3454, 4952], 'G.R.': [3178, 3200, 3432, 3455], '1991;': [3186], '88:': [3187], '11455-11459Crossref': [3188], '26.Darnell': [3194], '264:': [3203, 3435, 4530], '1415-1421Crossref': [3204, 3436], '(5061)': [3207, 3439], 'parental': [3211, 3325, 3483, 3517], '2fTGH': [3213, 3231, 3247, 3260, 3289, 3362, 3485, 3519], 'served': [3214], 'positive': [3216], 'control.': [3217], 'First,': [3218], 'potentials': [3224], 'both': [3230, 3355, 3515, 4053], 'cells.': [3234, 3363], 'detected': [3245], 'U4A.': [3251], 'Overexpression': [3252], '2-fold': [3262], 'supporting': [3270], 'notion': [3272], 'function.': [3280], 'overexpression': [3294], 'Again,': [3297], 'reasons': [3309], 'understand,': [3313], 'line,': [3326], '2fTGH.': [3327], 'constitutively': [3335, 3921, 3998, 4109, 4227, 4333, 4414], 'Jak3.': [3344], 'Next': [3345], 'lines': [3366], 'constructs': [3370], 'encoding': [3371, 4548], 'either': [3372, 4077], 'assayed': [3382], 'their': [3384], 'associate': [3387], 'STAT6-specific': [3390], 'our': [3400], 'earlier': [3404], 'data,': [3405], '(top': [3422, 3505], 'panel,': [3423, 3487, 3506], 'lane': [3424, 3488, 3507], '(26.Darnell': [3426], '27.Haque': [3442], 'S.J.': [3443], 'Q.': [3445], 'Kammer': [3446], 'W.': [3447], 'Friedrich': [3448, 4616], 'Smith': [3450], 'J.M.': [3451, 4699], 'Williams': [3456], 'B.R.': [3457], '94:': [3466], '8563-8568Crossref': [3467], '(65)': [3470], '(bottom': [3486], 'co-expressed,': [3494], 'reconstituted': [3501], '10).': [3508], '12).': [3536], 'require': [3547], 'Taken': [3550], 'together,': [3551], 'findings': [3553], 'does': [3564, 3642, 3943], 'need': [3566], 'that,': [3584, 3992], 'mutated,': [3586], 'uncouple': [3587], 'regulatory': [3596], 'cytokine,': [3597], 'IL-4.': [3598, 3618], 'mutant,': [3601], 'proteolysis,': [3621], 'observation': [3641, 3716], 'reflect': [3644], 'difference': [3646], 'differentially': [3654], '(data': [3665], 'shown).': [3667], 'stabilize': [3677], 'so': [3679], 'less': [3683, 4087], 'susceptible': [3684, 4088], 'seems': [3695], 'give': [3697], 'rise': [3698], 'kinase.': [3709, 3788], 'supported': [3713], 'phosphorylate': [3725, 3730], 'fail': [3728], 'forms': [3736], 'stable': [3739], 'protein:DNA': [3740], 'mechanisms,': [3748], 'stability,': [3759], 'Obviously,': [3770], 'rule': [3775], 'out': [3776], 'scenario,': [3791], 'may': [3793, 3805], 'rapidly': [3795], 'dephosphorylated': [3796], 'phosphatase': [3804], 'recognize': [3809], 'changes.': [3817], 'Our': [3818, 4394], 'us': [3823], 'discriminate': [3825], 'between': [3826], 'mechanisms.': [3830], 'Constitutively': [3831], 'versions': [3833], 'STAT1': [3835, 4335], 'STAT5': [3837, 3991, 4000, 4107], '(28.Shuai': [3841, 3923], 'Liao': [3843, 3925], 'Song': [3845, 3927], 'M.M.': [3846, 3928, 4257], '4932-4941Crossref': [3852, 3934], '(132)': [3855, 3937, 4589], '29.Onishi': [3858], 'Nosaka': [3860, 4004], 'Misawa': [3862, 4006], 'Mui': [3864, 4008], 'A.L.-F.': [3865, 4009], 'Gorman': [3866, 4010], 'McMahon': [3868, 4012], 'Miyajima': [3870, 4014], 'Ktamura': [3872, 4016], '18:': [3878, 4022, 4197, 4219], '3871-3879Crossref': [3879, 4023], '(349)': [3882, 4026], 'case': [3887], 'STAT1,': [3889], '31': [3899], '(Arg': [3900], 'Ala)': [3902], 'inhibits': [3903], 'dephosphorylation': [3905], 'STAT1.': [3907], 'deletion': [3910, 3949], 'N': [3913, 3952], 'terminus': [3914, 3953], 'similar': [3941, 4737], 'apply': [3945], 'activation/phosphorylation': [3959], 'properties': [3960], 'Two': [3984], 'mutated': [3994], 'simultaneously,': [3995], 'yield': [3996, 4072], '(29.Onishi': [4002], 'resides': [4032], 'upstream': [4034], 'other': [4042], 'C-terminal': [4047], 'Also': [4050], 'full': [4062], 'phenotype.': [4064], 'appears': [4067], 'different': [4069], 'ligand-independent': [4081], 'render': [4085], 'them': [4086], 'dephosphorylation.': [4090], 'Inappropriate': [4091], 'pathological': [4101], 'conditions.': [4102], 'example,': [4104], 'STAT3': [4105, 4138, 4229], 'HTLV-1': [4112], 'transformed': [4113], 'T-cells': [4114], '(30.Migone': [4115], 'T.S.': [4116], 'Lin': [4117], 'J.X.': [4118], 'Cereseto': [4119], 'Mulloy': [4121], 'J.C.': [4122], "O'Shea": [4123], 'Franchini': [4125], 'G.': [4126, 4265, 4271, 4525], 'Leonard': [4127], '269:': [4131, 4307], '79-81Crossref': [4132], '(507)': [4135], 'cytokine-independent': [4148], 'Src,': [4151], 'resulting': [4152], 'transformation': [4155], '(31.Campbell': [4156], 'G.S.,': [4157], 'Yu,': [4158], 'C.L.': [4159], 'Jove': [4160, 4191, 4274], 'Carter-Su': [4162], '272:': [4168], '2591-2594Abstract': [4169], '32.Turkson': [4180], 'Bowman': [4182], 'Garcia': [4184], 'Caldenhoven': [4186], 'De': [4188], 'Groot': [4189], 'R.P.': [4190, 4905], '2545-2552Crossref': [4198], '(594)': [4201], '33.Bromberg': [4204], 'J.F.': [4205], 'Horvath': [4206], 'C.M.': [4207], 'Besser': [4208], 'Lathem': [4210], 'W.W.': [4211], '2553-2558Crossref': [4220], '(571)': [4223], 'bone': [4233], 'marrow': [4234], 'mononuclear': [4235], 'multiple': [4240], 'myelomas': [4241], 'contribute': [4246], 'pathogenesis': [4248], 'preventing': [4250], 'apoptosis': [4251], '(34.Catlett-Falcone': [4252], 'Landowski': [4254], 'T.H.': [4255, 4527, 4917], 'Oshiro': [4256], 'Turkson': [4258], 'Levitzki': [4260], 'Savino': [4262], 'Ciliberto': [4264], 'Moscinski': [4266], 'Fernandez-Luna': [4268], 'J.L.': [4269], 'Nunez': [4270], 'Dalton': [4272], 'W.S.': [4273], '10:': [4278], '105-115Abstract': [4279], '(1454)': [4287], 'Also,': [4290], 'oncogene': [4292], 'v-abl': [4293], '(35.Danial': [4299], 'N.N.': [4300], 'Pernis': [4301], 'P.B.': [4304], '1875-1877Crossref': [4308], '(321)': [4311], '36.Carlesso': [4314], 'N.': [4315, 4624, 4695, 4831], 'Frank': [4316], 'D.A.': [4317], 'Griffin': [4318], 'J.D.': [4319, 4513, 4895], '183:': [4324], '811-820Crossref': [4325], '(434)': [4328], 'More': [4331], 'recently,': [4332], 'airway': [4340], 'epithelial': [4341], 'asthmatic': [4344], 'individuals': [4345, 4435], '(37.Sampath': [4346], 'Castro': [4348], 'Look': [4350], 'D.C.': [4351], 'Holtzman': [4352], 'Invest.': [4356], '103:': [4358], '1353-1361Crossref': [4359], '(200)': [4362], 'illustrate': [4367], 'inappropriate': [4370], 'activation/tyrosine': [4371], 'protein,': [4376], 'signaling,': [4382], 'profound': [4386], 'cell.': [4393], 'key': [4401], 'within': [4403], 'provides': [4416], 'first': [4418], 'reported': [4419], 'evidence': [4420], 'hyperactive': [4423], 'form': [4424], 'Asthma': [4427], 'familial,': [4429], 'loci': [4433], 'predispose': [4434, 4940], 'disease': [4438], '(38.Daniels': [4439], 'S.E.': [4440], 'Bhattacharrya': [4441], 'James': [4443], 'Leaves': [4445], 'N.I.': [4446], 'Young': [4447], 'Hill': [4449], 'M.R.': [4450], 'Faux': [4451], 'J.A.': [4452], 'Ryan': [4453, 4717], 'G.F.': [4454], 'le': [4455], 'Souef': [4456], 'P.N.': [4457, 4907], 'Lathrop': [4458], 'G.M.': [4459], 'Musk': [4460], 'A.W.': [4461], 'Cookson': [4462], 'W.O.': [4463], '247-250Crossref': [4467], '(712)': [4470], 'allergy': [4478], 'multifactorial': [4480], 'influenced': [4485], 'environmental': [4490], 'factors.': [4491], 'atopy,': [4501], 'IgE-mediated': [4503], 'syndrome': [4504], '(39.Marsh': [4510], 'D.G.': [4511, 4861, 4877, 4919], 'Neely': [4512, 4894], 'Breazeale': [4514, 4900], 'D.R.': [4515, 4901], 'Ghosh': [4516], 'Freidhoff': [4518, 4898], 'L.R.': [4519, 4899], 'Ehrlich-Kautzky': [4520], 'Schou': [4522, 4902], 'Krishnaswamy': [4524], 'Beaty': [4526, 4916], '1152-1156Crossref': [4531], '(953)': [4534], 'Gain-of-function': [4537], 'polymorphisms': [4538], 'higher': [4557], 'serum': [4558], 'levels': [4560, 4859], '(40.Deichmann': [4563], 'K.A.': [4564, 4593, 4649], 'Heinzmann': [4565, 4598], 'Forster': [4567, 4602, 4644], 'Dischinger': [4569], 'Mehl': [4571], 'Brueggenolte': [4573], 'Hildebrandt': [4575], 'F.': [4576, 4825], 'Moseler': [4577], 'Kuehr': [4579, 4604, 4646], '28:': [4585], '151-155Crossref': [4586], '41.Deichmann': [4592], 'Starke': [4594], 'Schlenther': [4596], 'Sparholt': [4600, 4642], 'S.H.': [4601, 4643], '36:': [4610], '379-382PubMed': [4611], '42.Hershey': [4614], 'G.K.': [4615], 'M.F.': [4617], 'Esswein': [4618], 'Thomas': [4620], 'M.L.': [4621], 'Chatila': [4622], 'T.A.': [4623], 'Engl.': [4625], '337:': [4629], '1720-1725Crossref': [4630], '(694)': [4633], '43.Kruse': [4636], 'Japha': [4638], 'Tedner': [4640], 'Deichmann': [4648], 'Immunology.': [4650], '96:': [4652], '365-371Crossref': [4653], '44.Izuhara': [4659], 'Shirakawa': [4661, 4696], 'Int.': [4663], '3:': [4668], '3-10PubMed': [4669], '45.Mitsuyasu': [4672], 'H.': [4673], 'Yanagihara': [4674], 'Mao': [4676], 'X.Q.': [4677], 'Gao': [4678], 'P.S.': [4679], 'Arinobu': [4680], 'Ihara': [4682], 'Takabayashi': [4684], 'Hara': [4686], 'Enomoto': [4688], 'Sasaki': [4690], 'Kawai': [4692], 'Hamasaki': [4694], 'Hopkin': [4698], 'Izuhara': [4700], '162:': [4705, 4724], '1227-1231PubMed': [4706], '46.Wang': [4709], 'Shelburne': [4711], 'C.P.': [4712], 'Zamorano': [4713], 'Kelly': [4715], 'A.E.': [4716], '4385-4389PubMed': [4725], 'phenotype,': [4738], 'production': [4741], '(11.Akira': [4748], '19.Kuperman': [4760], '47.Akimoto': [4822], 'Numata': [4824], 'Tamura': [4826], 'Takata': [4828], 'Higashida': [4830], 'Takashi': [4832], '1537-1542Crossref': [4843], '(284)': [4846], '(23.Marsh': [4860], '409:': [4867], '43-53Crossref': [4868], '(6)': [4871], '48.Barnes': [4874], 'K.C.': [4875, 4893], 'Marsh': [4876, 4918], 'Today.': [4879], '19:': [4881], '325-332Abstract': [4882], '(109)': [4890], 'Scholar,49.Barnes': [4892], 'Duffy': [4896], 'D.L.': [4897], 'Naidu': [4904], 'Levett': [4906], 'Renault': [4908], 'Kucherlapati': [4910], 'Iozzino': [4912], 'Ehrlich': [4914], 'Genomics.': [4920], '37:': [4922], '41-50Crossref': [4923], '(215)': [4926], 'speculate': [4932], 'thank': [4949, 4976], 'providing': [4954, 4971], 'Drs.': [4960], 'Holger': [4961], 'Beckmann,': [4962], 'Tim': [4963], 'Hoey,': [4964], 'Gabrielle': [4965], 'Schaefer,': [4966], 'Chandrasekar': [4968], 'Venkataraman': [4969], 'comments.': [4973], 'So-Hyung': [4977], 'Lee': [4978], 'technical': [4980], 'assistance.': [4981]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2060265430', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2025-01-10T11:08:03.422625', 'created_date': '2016-06-24'}
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