Title: EVALUATION OF ANTIHUMAN ANTILYMPHOCYTE SERUM WITH THE ROSETTE INHIBITION TEST USING HUMAN AND CYNOMOLGUS THYMOCYTES
Abstract: SUMMARY The thymus of every cynomolgus monkey investigated contained a great number of rosette-forming cells. The same observation was made in the two human thymuses studied. A number of monkeys, however, had few or no rosette-forming cells in their blood, spleen, or bone marrow. The phenomenon of rosette formation is discussed. Antihuman antilymphocyte serum (ALS) can inhibit rosette formation by cynomolgus monkey thymocytes. A high correlation was found between the titers obtained using human blood lymphocytes, human thymocytes, or monkey thymocytes. The titers in the rosette inhibition test are statistically significant in comparison with the immunosuppressive activity in monkeys, although there were a few exceptions.