Production of functional human α 1 -antitrypsin by plant cell culture

Name: Work Video:
Duration: 3 min 30 s
M. Terashima; Yasuo Murai; Makoto Kawamura; S. Nakanishi; T. Stoltz; L. Chen; William N. Drohan; Raymond L. Rodriguez; S. Katoh
{'id': 'https://openalex.org/W2059849821', 'doi': 'https://doi.org/10.1007/s002530051554', 'title': 'Production of functional human α 1 -antitrypsin by plant cell culture', 'display_name': 'Production of functional human α 1 -antitrypsin by plant cell culture', 'publication_year': 1999, 'publication_date': '1999-10-21', 'ids': {'openalex': 'https://openalex.org/W2059849821', 'doi': 'https://doi.org/10.1007/s002530051554', 'mag': '2059849821', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10570799'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s002530051554', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S70979998', 'display_name': 'Applied Microbiology and Biotechnology', 'issn_l': '0175-7598', 'issn': ['0175-7598', '1432-0614'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5109876457', 'display_name': 'M. Terashima', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I15807432', 'display_name': 'Osaka Prefecture University', 'ror': 'https://ror.org/02cf1je33', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I15807432']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'M. Terashima', 'raw_affiliation_strings': ['Department of Chemical Engineering, Osaka Prefecture University, Sakai, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemical Engineering, Osaka Prefecture University, Sakai, Japan.', 'institution_ids': ['https://openalex.org/I15807432']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004895935', 'display_name': 'Yasuo Murai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Y. Murai', 'raw_affiliation_strings': ['Department of Synthetic Chemistry and Biological Chemistry, Kyoto University, Kyoto 606–01, Japan, , JP'], 'affiliations': [{'raw_affiliation_string': 'Department of Synthetic Chemistry and Biological Chemistry, Kyoto University, Kyoto 606–01, Japan, , JP', 'institution_ids': ['https://openalex.org/I22299242']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037835758', 'display_name': 'Makoto Kawamura', 'orcid': 'https://orcid.org/0000-0001-6117-2736'}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'M. Kawamura', 'raw_affiliation_strings': ['Department of Synthetic Chemistry and Biological Chemistry, Kyoto University, Kyoto 606–01, Japan, , JP'], 'affiliations': [{'raw_affiliation_string': 'Department of Synthetic Chemistry and Biological Chemistry, Kyoto University, Kyoto 606–01, Japan, , JP', 'institution_ids': ['https://openalex.org/I22299242']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032755468', 'display_name': 'S. Nakanishi', 'orcid': 'https://orcid.org/0000-0001-5202-562X'}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'S. Nakanishi', 'raw_affiliation_strings': ['Section of Molecular Biology and Cellular Biology, University of California, Davis, Davis, CA 95616, USA, US'], 'affiliations': [{'raw_affiliation_string': 'Section of Molecular Biology and Cellular Biology, University of California, Davis, Davis, CA 95616, USA, US', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037899253', 'display_name': 'T. Stoltz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210094202', 'display_name': 'Applied BioMath (United States)', 'ror': 'https://ror.org/00j3vdq65', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210094202']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'T. Stoltz', 'raw_affiliation_strings': ['Applied Phytologics, Inc., 4110 North Freeway Blvd., Sacramento, CA 95834–1219, USA, , US'], 'affiliations': [{'raw_affiliation_string': 'Applied Phytologics, Inc., 4110 North Freeway Blvd., Sacramento, CA 95834–1219, USA, , US', 'institution_ids': ['https://openalex.org/I4210094202']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041245886', 'display_name': 'L. Chen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1311914864', 'display_name': 'Scripps Health', 'ror': 'https://ror.org/05bhsww40', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1311914864']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'L. Chen', 'raw_affiliation_strings': ['Division of Plant Biotechnology, Scripps Research Foundation, La Jolla, CA 92037, USA, US'], 'affiliations': [{'raw_affiliation_string': 'Division of Plant Biotechnology, Scripps Research Foundation, La Jolla, CA 92037, USA, US', 'institution_ids': ['https://openalex.org/I1311914864']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024216593', 'display_name': 'William N. Drohan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1343864894', 'display_name': 'American Red Cross', 'ror': 'https://ror.org/0284e2q78', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1343864894']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'W. Drohan', 'raw_affiliation_strings': ['American Red Cross Holland Laboratory, Rockville, MD 20855, USA, NL'], 'affiliations': [{'raw_affiliation_string': 'American Red Cross Holland Laboratory, Rockville, MD 20855, USA, NL', 'institution_ids': ['https://openalex.org/I1343864894']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091755709', 'display_name': 'Raymond L. Rodriguez', 'orcid': 'https://orcid.org/0000-0002-6105-2571'}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'R. L. Rodriguez', 'raw_affiliation_strings': ['Section of Molecular Biology and Cellular Biology, University of California, Davis, Davis, CA 95616, USA, US'], 'affiliations': [{'raw_affiliation_string': 'Section of Molecular Biology and Cellular Biology, University of California, Davis, Davis, CA 95616, USA, US', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5114250819', 'display_name': 'S. Katoh', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I65837984', 'display_name': 'Kobe University', 'ror': 'https://ror.org/03tgsfw79', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I65837984']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'S. Katoh', 'raw_affiliation_strings': ['Graduate School of Science and Technology, Kobe University, Rokkodai, Nada-ku, Kobe 657–8501, Japan, , JP'], 'affiliations': [{'raw_affiliation_string': 'Graduate School of Science and Technology, Kobe University, Rokkodai, Nada-ku, Kobe 657–8501, Japan, , JP', 'institution_ids': ['https://openalex.org/I65837984']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 7, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3390, 'currency': 'EUR', 'value_usd': 4390, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 6.146, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 133, 'citation_normalized_percentile': {'value': 0.999504, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '52', 'issue': '4', 'first_page': '516', 'last_page': '523'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12856', 'display_name': 'Transgenic Plants and Applications', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12856', 'display_name': 'Transgenic Plants and Applications', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11663', 'display_name': 'Viral Infectious Diseases and Gene Expression in Insects', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12929', 'display_name': 'Animal Genetics and Reproduction', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C10858879', 'wikidata': 'https://www.wikidata.org/wiki/Q899790', 'display_name': 'Signal peptide', 'level': 4, 'score': 0.74894863}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6771222}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.6380401}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.56127304}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.4983542}, {'id': 'https://openalex.org/C33161422', 'wikidata': 'https://www.wikidata.org/wiki/Q5421712', 'display_name': 'Expression vector', 'level': 4, 'score': 0.49046418}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.44515193}, {'id': 'https://openalex.org/C167625842', 'wikidata': 'https://www.wikidata.org/wiki/Q899763', 'display_name': 'Peptide sequence', 'level': 3, 'score': 0.43866777}, {'id': 'https://openalex.org/C40767141', 'wikidata': 'https://www.wikidata.org/wiki/Q285697', 'display_name': 'Recombinant DNA', 'level': 3, 'score': 0.33539018}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.23194501}, {'id': 'https://openalex.org/C149923435', 'wikidata': 'https://www.wikidata.org/wiki/Q37732', 'display_name': 'Demography', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C144024400', 'wikidata': 'https://www.wikidata.org/wiki/Q21201', 'display_name': 'Sociology', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D012275', 'descriptor_name': 'Oryza', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000515', 'descriptor_name': 'alpha 1-Antitrypsin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019149', 'descriptor_name': 'Bioreactors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002846', 'descriptor_name': 'Chromatography, Affinity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005822', 'descriptor_name': 'Genetic Vectors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005822', 'descriptor_name': 'Genetic Vectors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012275', 'descriptor_name': 'Oryza', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D013696', 'descriptor_name': 'Temperature', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014170', 'descriptor_name': 'Transformation, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000515', 'descriptor_name': 'alpha 1-Antitrypsin', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000515', 'descriptor_name': 'alpha 1-Antitrypsin', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000515', 'descriptor_name': 'alpha 1-Antitrypsin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s002530051554', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S70979998', 'display_name': 'Applied Microbiology and Biotechnology', 'issn_l': '0175-7598', 'issn': ['0175-7598', '1432-0614'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10570799', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 1, 'referenced_works': ['https://openalex.org/W2024429016'], 'related_works': ['https://openalex.org/W973393354', 'https://openalex.org/W2572680590', 'https://openalex.org/W2408202795', 'https://openalex.org/W2408202374', 'https://openalex.org/W2388438194', 'https://openalex.org/W2360457928', 'https://openalex.org/W2070403223', 'https://openalex.org/W2047512635', 'https://openalex.org/W2023556160', 'https://openalex.org/W1977929887'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2059849821', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2025-01-06T04:19:07.818325', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
