Publication Information

{'id': 'https://openalex.org/W2059834473', 'doi': 'https://doi.org/10.1002/ana.410240506', 'title': "Neurofibrillary tangles in cholinergic pedunculopontine neurons in Alzheimer's disease", 'display_name': "Neurofibrillary tangles in cholinergic pedunculopontine neurons in Alzheimer's disease", 'publication_year': 1988, 'publication_date': '1988-11-01', 'ids': {'openalex': 'https://openalex.org/W2059834473', 'doi': 'https://doi.org/10.1002/ana.410240506', 'mag': '2059834473', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/3202615'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/ana.410240506', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S114530997', 'display_name': 'Annals of Neurology', 'issn_l': '0364-5134', 'issn': ['0364-5134', '1531-8249'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5111770655', 'display_name': 'Elliott J. Mufson', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Elliott J. Mufson', 'raw_affiliation_strings': ['L. J. Roberts Center, Institute for Biogerontology Research, Sun City, AZ'], 'affiliations': [{'raw_affiliation_string': 'L. J. Roberts Center, Institute for Biogerontology Research, Sun City, AZ', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084723460', 'display_name': 'Deborah C. Mash', 'orcid': 'https://orcid.org/0000-0002-1352-7851'}, 'institutions': [{'id': 'https://openalex.org/I145608581', 'display_name': 'University of Miami', 'ror': 'https://ror.org/02dgjyy92', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145608581']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Deborah C. Mash', 'raw_affiliation_strings': ['Department of Neurology and Pharmacology, University of Miami Medical School, Miami, FL'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology and Pharmacology, University of Miami Medical School, Miami, FL', 'institution_ids': ['https://openalex.org/I145608581']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5109249437', 'display_name': 'Louis B. Hersh', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210094379', 'display_name': 'University of Texas Health Science Center at Dallas', 'ror': 'https://ror.org/00q16t150', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I4210094379']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Louis B. Hersh', 'raw_affiliation_strings': ['Department of Biochemistry, University of Texas Health Science Center, Dallas, TX'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, University of Texas Health Science Center, Dallas, TX', 'institution_ids': ['https://openalex.org/I4210094379']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3610, 'currency': 'USD', 'value_usd': 3610, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 7.331, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 86, 'citation_normalized_percentile': {'value': 0.976608, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '24', 'issue': '5', 'first_page': '623', 'last_page': '629'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12023', 'display_name': 'Cholinesterase and Neurodegenerative Diseases', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12023', 'display_name': 'Cholinesterase and Neurodegenerative Diseases', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10077', 'display_name': 'Neuroscience and Neuropharmacology Research', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10448', 'display_name': 'Memory and Neural Mechanisms', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2805', 'display_name': 'Cognitive Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pedunculopontine-nucleus', 'display_name': 'Pedunculopontine nucleus', 'score': 0.89789}, {'id': 'https://openalex.org/keywords/pedunculopontine-tegmental-nucleus', 'display_name': 'Pedunculopontine Tegmental Nucleus', 'score': 0.7185309}], 'concepts': [{'id': 'https://openalex.org/C2781153452', 'wikidata': 'https://www.wikidata.org/wiki/Q3345673', 'display_name': 'Pedunculopontine nucleus', 'level': 5, 'score': 0.89789}, {'id': 'https://openalex.org/C104966671', 'wikidata': 'https://www.wikidata.org/wiki/Q12167532', 'display_name': 'Cholinergic neuron', 'level': 3, 'score': 0.73909265}, {'id': 'https://openalex.org/C2909170305', 'wikidata': 'https://www.wikidata.org/wiki/Q3345673', 'display_name': 'Pedunculopontine Tegmental Nucleus', 'level': 3, 'score': 0.7185309}, {'id': 'https://openalex.org/C22885893', 'wikidata': 'https://www.wikidata.org/wiki/Q4862743', 'display_name': 'Cholinergic', 'level': 2, 'score': 0.6626244}, {'id': 'https://openalex.org/C198399640', 'wikidata': 'https://www.wikidata.org/wiki/Q14863671', 'display_name': 'Choline acetyltransferase', 'level': 3, 'score': 0.62729454}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.5253279}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5049315}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.42278016}, {'id': 'https://openalex.org/C2780723820', 'wikidata': 'https://www.wikidata.org/wiki/Q1934178', 'display_name': 'Nucleus', 'level': 2, 'score': 0.42263728}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.37791863}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.25255954}, {'id': 'https://openalex.org/C2779734285', 'wikidata': 'https://www.wikidata.org/wiki/Q11085', 'display_name': "Parkinson's disease", 'level': 3, 'score': 0.24087468}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.20290425}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.11558962}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C2778542668', 'wikidata': 'https://www.wikidata.org/wiki/Q618076', 'display_name': 'Deep brain stimulation', 'level': 4, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D002799', 'descriptor_name': 'Cholinergic Fibers', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D009454', 'descriptor_name': 'Neurofibrils', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D011149', 'descriptor_name': 'Pons', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D000110', 'descriptor_name': 'Acetylcholinesterase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000110', 'descriptor_name': 'Acetylcholinesterase', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002795', 'descriptor_name': 'Choline O-Acetyltransferase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002795', 'descriptor_name': 'Choline O-Acetyltransferase', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D002799', 'descriptor_name': 'Cholinergic Fibers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002799', 'descriptor_name': 'Cholinergic Fibers', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009249', 'descriptor_name': 'NADP', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009249', 'descriptor_name': 'NADP', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D009454', 'descriptor_name': 'Neurofibrils', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009454', 'descriptor_name': 'Neurofibrils', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D011149', 'descriptor_name': 'Pons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011149', 'descriptor_name': 'Pons', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D013681', 'descriptor_name': 'Tegmentum Mesencephali', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013681', 'descriptor_name': 'Tegmentum Mesencephali', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D013681', 'descriptor_name': 'Tegmentum Mesencephali', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/ana.410240506', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S114530997', 'display_name': 'Annals of Neurology', 'issn_l': '0364-5134', 'issn': ['0364-5134', '1531-8249'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/3202615', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.75}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 39, 'referenced_works': ['https://openalex.org/W1511379621', 'https://openalex.org/W1554082519', 'https://openalex.org/W1977252507', 'https://openalex.org/W1980960797', 'https://openalex.org/W1981576090', 'https://openalex.org/W1994885960', 'https://openalex.org/W1996638302', 'https://openalex.org/W2011279980', 'https://openalex.org/W2013854477', 'https://openalex.org/W2015298048', 'https://openalex.org/W2015653992', 'https://openalex.org/W2018434736', 'https://openalex.org/W2020683665', 'https://openalex.org/W2022297475', 'https://openalex.org/W2023005921', 'https://openalex.org/W2033149670', 'https://openalex.org/W2042348810', 'https://openalex.org/W2044484376', 'https://openalex.org/W2045290451', 'https://openalex.org/W2046096408', 'https://openalex.org/W2049485817', 'https://openalex.org/W2050665230', 'https://openalex.org/W2056424357', 'https://openalex.org/W2059360174', 'https://openalex.org/W2073861859', 'https://openalex.org/W2076824965', 'https://openalex.org/W2078237037', 'https://openalex.org/W2086780496', 'https://openalex.org/W2091947549', 'https://openalex.org/W2126974689', 'https://openalex.org/W2138166961', 'https://openalex.org/W2147608198', 'https://openalex.org/W2147786044', 'https://openalex.org/W2149906893', 'https://openalex.org/W2154584808', 'https://openalex.org/W2400844645', 'https://openalex.org/W2411352353', 'https://openalex.org/W2976351999', 'https://openalex.org/W50122120'], 'related_works': ['https://openalex.org/W4241186036', 'https://openalex.org/W2158989951', 'https://openalex.org/W2140634028', 'https://openalex.org/W2118123933', 'https://openalex.org/W2078527249', 'https://openalex.org/W2072042478', 'https://openalex.org/W2050472943', 'https://openalex.org/W2029536642', 'https://openalex.org/W1972026743', 'https://openalex.org/W1963572609'], 'abstract_inverted_index': {'Abstract': [0], 'The': [1, 88, 118, 174], 'cholinergic': [2, 86, 96, 178], 'neurons': [3, 69, 97, 179], 'located': [4], 'within': [5, 70, 98, 124], 'the': [6, 71, 82, 95, 99, 104, 128, 155, 181, 186, 196], 'pedunculopontine': [7, 72, 105, 129, 187], 'nucleus': [8, 106, 130, 188], '(Ch5)': [9], 'of': [10, 68, 85, 90, 103, 121, 127, 158, 177, 180, 185, 195, 200], 'patients': [11, 136], 'with': [12, 94, 116, 137, 144], "Alzheimer's": [13], 'disease': [14, 20], '(AD;': [15], 'n': [16, 22], '=': [17, 23, 29], '15),': [18], "Parkinson's": [19], '(PD;': [21], '2),': [24], 'and': [25, 62, 146, 169], 'neurologically': [26], 'normal': [27], '(n': [28], '6)': [30], 'subjects': [31], 'were': [32, 166, 171], 'visualized': [33], 'immunohistochemically': [34], 'using': [35, 39, 46], 'choline': [36], 'acetyltransferase,': [37], 'pharmacohistochemically': [38], 'acetylcholinesterase,': [40], 'or': [41], 'by': [42], 'reduced': [43], 'histochemical': [44, 54], 'methods': [45], 'nicotinamide': [47], 'adenine': [48], 'dinucleotide': [49], 'phosphate': [50], 'diaphorase': [51], '(NADPH‐d).': [52], 'Each': [53], 'procedure': [55], 'localized': [56], 'a': [57, 63, 191], 'well‐delineated,': [58], 'compact': [59, 100, 182], 'lateral': [60, 101, 183], 'group': [61, 67], 'more': [64], 'diffuse': [65], 'medial': [66], 'nucleus.': [73], 'Co‐localization': [74], 'experiments': [75], 'revealed': [76], 'that': [77, 111], 'all': [78], 'three': [79], 'enzymes': [80], 'Marchked': [81], 'same': [83], 'population': [84], 'neurons.': [87, 173], 'extent': [89], 'pathological': [91, 175], 'alterations': [92], 'associated': [93], 'sector': [102], 'was': [107, 131], 'examined': [108], 'in': [109, 135, 142, 150, 162, 193], 'sections': [110], 'reacted': [112], 'for': [113], 'NADPH‐d,': [114], 'counterstained': [115], 'thioflavin‐S.': [117], 'average': [119], 'number': [120, 157], 'neurofibrillary': [122, 159], 'tangles': [123, 160], 'this': [125], 'portion': [126], '25.4': [132], '(range': [133, 140, 148], '0–70)': [134], 'AD,': [138], '1.5': [139], '1–2)': [141], 'those': [143], 'PD,': [145], '1.2': [147], '0–4)': [149], 'aged': [151], 'control': [152], 'subjects.': [153], 'Of': [154], 'total': [156], 'counted': [161], 'AD': [163], 'cases,': [164], '72.7%': [165], 'end‐stage': [167], 'ghosts': [168], '27.3%': [170], 'tangle‐bearing': [172], 'alteration': [176], 'aspect': [184], 'may': [189], 'play': [190], 'role': [192], 'some': [194], 'behavioral': [197], 'features': [198], 'characteristic': [199], 'AD.': [201]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2059834473', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-11T11:13:05.870588', 'created_date': '2016-06-24'}