Title: Epstein-Barr virus activation of human epithelial—Nasopharyngeal carcinoma hybrid cells
Abstract: The authors used indirect immunofluorescence and electron microscopic techniques tostudy the effects of 5-iododeoxyuridine (IUDR) and the tumor promotor 12-0-tetradecanoylphorbol-13-acetate (TPA) on the epithelial hybrid cell line (NPC-KT) derived from nasopharyngeal carcinoma. The hybrid cells contained Epstein-Barr virus (EBV)—induced early antigens at a very low level but not Epstein-Barr viral capsid antigens in spontaneous production; the hybrid cells responded significantly to both IUDR and TPA induction. The chemicals induced both early antigens and viral capsid antigens in the NPC-KT cells. Moreover, the virus particles were detected in the altered NPC-KT cells by IUDR treatment. The data suggest that the EBV-induced agents activate the EBV productive cycle in a proportion of nasopharyngeal carcinoma cells.
Publication Year: 1984
Publication Date: 1984-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 6
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