Publication Information

{'id': 'https://openalex.org/W2059798805', 'doi': 'https://doi.org/10.1111/j.1365-2141.1976.tb00190.x', 'title': 'Alpha‐Thalassaemia Trait in Various Racial Groups in the United Kingdom: Characterization of a Variant of Alpha‐Thalassaemia in Indians*', 'display_name': 'Alpha‐Thalassaemia Trait in Various Racial Groups in the United Kingdom: Characterization of a Variant of Alpha‐Thalassaemia in Indians*', 'publication_year': 1976, 'publication_date': '1976-10-01', 'ids': {'openalex': 'https://openalex.org/W2059798805', 'doi': 'https://doi.org/10.1111/j.1365-2141.1976.tb00190.x', 'mag': '2059798805', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/974033'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1365-2141.1976.tb00190.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S153015021', 'display_name': 'British Journal of Haematology', 'issn_l': '0007-1048', 'issn': ['0007-1048', '1365-2141'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5108681953', 'display_name': 'Diana M. Walford', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802052328', 'display_name': 'Northwick Park Hospital', 'ror': 'https://ror.org/030j6qm79', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800484787', 'https://openalex.org/I2802052328']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Diana M. Walford', 'raw_affiliation_strings': ['Department of Haematology, Northwick Park Hospital and Clinical Research Centre, Harrow, Middlesex'], 'affiliations': [{'raw_affiliation_string': 'Department of Haematology, Northwick Park Hospital and Clinical Research Centre, Harrow, Middlesex', 'institution_ids': ['https://openalex.org/I2802052328']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5070144705', 'display_name': 'Rosemary Deacon', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802052328', 'display_name': 'Northwick Park Hospital', 'ror': 'https://ror.org/030j6qm79', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800484787', 'https://openalex.org/I2802052328']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Rosemary Deacon', 'raw_affiliation_strings': ['Department of Haematology, Northwick Park Hospital and Clinical Research Centre, Harrow, Middlesex'], 'affiliations': [{'raw_affiliation_string': 'Department of Haematology, Northwick Park Hospital and Clinical Research Centre, Harrow, Middlesex', 'institution_ids': ['https://openalex.org/I2802052328']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4940, 'currency': 'USD', 'value_usd': 4940, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.441, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 29, 'citation_normalized_percentile': {'value': 0.816183, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '34', 'issue': '2', 'first_page': '193', 'last_page': '206'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10554', 'display_name': 'Hemoglobinopathies and Related Disorders', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10554', 'display_name': 'Hemoglobinopathies and Related Disorders', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12286', 'display_name': 'Erythrocyte Function and Pathophysiology', 'score': 0.9328, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10452', 'display_name': 'Iron Metabolism and Disorders', 'score': 0.9169, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/alpha', 'display_name': 'Alpha (finance)', 'score': 0.68931746}, {'id': 'https://openalex.org/keywords/heterozygote-advantage', 'display_name': 'Heterozygote advantage', 'score': 0.6883432}, {'id': 'https://openalex.org/keywords/sickle-cell-trait', 'display_name': 'Sickle cell trait', 'score': 0.6617496}, {'id': 'https://openalex.org/keywords/red-cell', 'display_name': 'Red Cell', 'score': 0.583348}, {'id': 'https://openalex.org/keywords/beta-thalassaemia', 'display_name': 'Beta-thalassaemia', 'score': 0.51931685}, {'id': 'https://openalex.org/keywords/beta', 'display_name': 'BETA (programming language)', 'score': 0.4993415}, {'id': 'https://openalex.org/keywords/trait', 'display_name': 'Trait', 'score': 0.48277226}, {'id': 'https://openalex.org/keywords/hemoglobinopathy', 'display_name': 'Hemoglobinopathy', 'score': 0.4814336}], 'concepts': [{'id': 'https://openalex.org/C64943373', 'wikidata': 'https://www.wikidata.org/wiki/Q2651003', 'display_name': 'Alpha (finance)', 'level': 4, 'score': 0.68931746}, {'id': 'https://openalex.org/C153471976', 'wikidata': 'https://www.wikidata.org/wiki/Q2873354', 'display_name': 'Heterozygote advantage', 'level': 4, 'score': 0.6883432}, {'id': 'https://openalex.org/C2777566322', 'wikidata': 'https://www.wikidata.org/wiki/Q3536635', 'display_name': 'Sickle cell trait', 'level': 3, 'score': 0.6617496}, {'id': 'https://openalex.org/C2777208419', 'wikidata': 'https://www.wikidata.org/wiki/Q4347672', 'display_name': 'Red Cell', 'level': 2, 'score': 0.583348}, {'id': 'https://openalex.org/C2909410647', 'wikidata': 'https://www.wikidata.org/wiki/Q3616632', 'display_name': 'Beta-thalassaemia', 'level': 3, 'score': 0.51931685}, {'id': 'https://openalex.org/C2776174256', 'wikidata': 'https://www.wikidata.org/wiki/Q830842', 'display_name': 'BETA (programming language)', 'level': 2, 'score': 0.4993415}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.49710944}, {'id': 'https://openalex.org/C2776557347', 'wikidata': 'https://www.wikidata.org/wiki/Q37187', 'display_name': 'Red blood cell', 'level': 2, 'score': 0.49388486}, {'id': 'https://openalex.org/C106934330', 'wikidata': 'https://www.wikidata.org/wiki/Q1971873', 'display_name': 'Trait', 'level': 2, 'score': 0.48277226}, {'id': 'https://openalex.org/C2779668550', 'wikidata': 'https://www.wikidata.org/wiki/Q1642147', 'display_name': 'Hemoglobinopathy', 'level': 3, 'score': 0.4814336}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.46491084}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.41491413}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.33707356}, {'id': 'https://openalex.org/C2777799968', 'wikidata': 'https://www.wikidata.org/wiki/Q185137', 'display_name': 'Thalassemia', 'level': 2, 'score': 0.31250668}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.27255952}, {'id': 'https://openalex.org/C135763542', 'wikidata': 'https://www.wikidata.org/wiki/Q106016', 'display_name': 'Genotype', 'level': 3, 'score': 0.24765095}, {'id': 'https://openalex.org/C2776175824', 'wikidata': 'https://www.wikidata.org/wiki/Q1145668', 'display_name': 'Hemolytic anemia', 'level': 2, 'score': 0.22881195}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.18090385}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.10395184}, {'id': 'https://openalex.org/C49453240', 'wikidata': 'https://www.wikidata.org/wiki/Q1592163', 'display_name': 'Construct validity', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C2775944032', 'wikidata': 'https://www.wikidata.org/wiki/Q22907659', 'display_name': 'Patient satisfaction', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C199360897', 'wikidata': 'https://www.wikidata.org/wiki/Q9143', 'display_name': 'Programming language', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D014644', 'descriptor_name': 'Genetic Variation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D013789', 'descriptor_name': 'Thalassemia', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D002681', 'descriptor_name': 'China', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005914', 'descriptor_name': 'Globins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005914', 'descriptor_name': 'Globins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D006115', 'descriptor_name': 'Greece', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006441', 'descriptor_name': 'Hemoglobin A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006441', 'descriptor_name': 'Hemoglobin A', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007194', 'descriptor_name': 'India', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013789', 'descriptor_name': 'Thalassemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013789', 'descriptor_name': 'Thalassemia', 'qualifier_ui': 'Q000453', 'qualifier_name': 'epidemiology', 'is_major_topic': False}, {'descriptor_ui': 'D013789', 'descriptor_name': 'Thalassemia', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D006113', 'descriptor_name': 'United Kingdom', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1365-2141.1976.tb00190.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S153015021', 'display_name': 'British Journal of Haematology', 'issn_l': '0007-1048', 'issn': ['0007-1048', '1365-2141'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/974033', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 23, 'referenced_works': ['https://openalex.org/W1547680166', 'https://openalex.org/W1979893178', 'https://openalex.org/W2000209787', 'https://openalex.org/W2006736602', 'https://openalex.org/W2020720571', 'https://openalex.org/W2026912546', 'https://openalex.org/W2027203353', 'https://openalex.org/W2034625399', 'https://openalex.org/W2035573555', 'https://openalex.org/W2041575981', 'https://openalex.org/W2042555068', 'https://openalex.org/W2053899206', 'https://openalex.org/W2054480827', 'https://openalex.org/W2089053284', 'https://openalex.org/W2146696132', 'https://openalex.org/W2158926190', 'https://openalex.org/W2292385629', 'https://openalex.org/W2339543696', 'https://openalex.org/W2405003634', 'https://openalex.org/W2406894978', 'https://openalex.org/W3142260978', 'https://openalex.org/W334513376', 'https://openalex.org/W63041568'], 'related_works': ['https://openalex.org/W4313204457', 'https://openalex.org/W4285400651', 'https://openalex.org/W3042516554', 'https://openalex.org/W2611845932', 'https://openalex.org/W2474015635', 'https://openalex.org/W2411765148', 'https://openalex.org/W2091954090', 'https://openalex.org/W2074769873', 'https://openalex.org/W1990841564', 'https://openalex.org/W1516521923'], 'abstract_inverted_index': {'Patients': [0, 55], 'whose': [1], 'red-cell': [2, 188, 190], 'indices': [3, 191], 'are': [4], 'suggestive': [5], 'of': [6, 20, 24, 36, 45, 47, 52, 63, 65, 75, 84, 94, 106, 112, 148, 159, 165, 184, 187, 194, 244, 252, 308, 314, 330, 342], 'thalassaemia': [7], 'trait,': [8, 203], 'but': [9], 'who': [10], 'have': [11], 'a': [12, 60, 69, 128, 136, 245, 253, 274], 'normal': [13], 'haemoglobin': [14, 96, 229, 293], 'electrophoretic': [15], 'pattern,': [16], 'may': [17], 'be': [18, 238, 273], 'carriers': [19, 243, 251], 'alpha-thalassaemia.': [21], 'A': [22, 109, 318], 'diagnosis': [23], 'alpha-thalassaemia': [25, 57, 104, 152, 202, 264, 278, 310, 324], 'trait': [26, 58, 177, 265, 279], 'was': [27, 88, 100, 140, 205], 'made': [28], 'in': [29, 102, 116, 135, 144, 151, 182, 266, 268, 280, 287, 300, 339], '44': [30], 'such': [31], 'patients,': [32], 'using': [33], 'the': [34, 42, 48, 66, 95, 123, 145, 160, 179, 209, 215, 218, 234, 259, 290, 306, 315, 328, 331, 336, 340, 343], 'incorporation': [35], '[3H]leucine': [37], 'by': [38], 'reticulocytes': [39], 'to': [40, 240, 262, 272], 'measure': [41], 'relative': [43], 'rates': [44], 'synthesis': [46, 64], 'alpha-': [49, 170], 'and': [50, 118, 171, 192, 214, 226, 250, 289, 327], 'beta-chains': [51], 'adult': [53], 'haemoglobin.': [54], 'with': [56, 68, 157, 169, 201], 'had': [59], 'reduced': [61], 'rate': [62], 'alpha-chains,': [67], 'mean': [70, 79, 146, 222, 227], 'alpha/beta': [71, 80, 210, 235], 'specific': [72, 81, 211], 'activity': [73, 82, 212], 'ratio': [74, 83, 213, 236], '0.79+/-SD': [76], '0.07.': [77], 'The': [78, 91], '20': [85], 'control': [86, 161], 'subjects': [87], '1.06+/-SD': [89], '0.08.': [90], 'diagnostic': [92], 'value': [93], 'H(Hb': [97], 'H)': [98], 'preparation': [99], 'assessed': [101], 'proven': [103], 'heterozygotes': [105, 120, 153], 'various': [107], 'races.': [108], 'high': [110], 'proportion': [111], "'false": [113], "negative'": [114], 'results': [115], 'Indian': [117, 309, 323], 'Negro': [119], 'indicated': [121], 'that': [122, 158, 175, 233, 285, 292, 305], 'Hb': [124, 149], 'H': [125], 'preparations': [126], 'is': [127, 178, 258, 282, 325, 333], 'highly': [129], 'unreliable': [130], 'screening': [131], 'test': [132], 'for': [133, 322], 'use': [134], 'multi-racial': [137], 'population.': [138], 'There': [139], 'no': [141, 206], 'significant': [142], 'difference': [143], 'level': [147], 'A2': [150], '(2.0+/0SD': [154], '0.6)': [155], 'compared': [156], 'group': [162], '(2.1+/0SD0.5).': [163], 'Comparison': [164], 'data': [166], 'from': [167, 312], 'patients': [168, 200], 'beta-thalassaemia': [172], 'traits': [173], 'showed': [174], 'alpha-thalssaemia': [176], 'milder': [180, 283], 'disorder,': [181], 'terms': [183], 'its': [185], 'effects': [186], 'morphology,': [189], 'degree': [193], 'globin': [195], 'chain': [196], 'imbalance.': [197], 'Amongst': [198], 'individual': [199], 'there': [204], 'correlation': [207], 'between': [208, 242], 'red-blood-cell(RBC)': [216], 'd': [217], 'red-blood-cell': [219], '(RBC)': [220], 'count,': [221], 'corpuscular': [223, 228], 'volume': [224], '(MCV)': [225], '(MCH).': [230], 'This': [231, 257], 'suggests': [232], 'cannot': [237], 'used': [239], 'distinguish': [241], 'mild': [246], 'gene': [247], "('silent": [248], "carriers')": [249], 'more': [254], 'severe': [255], 'disease.': [256, 317], 'first': [260, 337], 'sutdy': [261], 'characterize': [263], 'Indians,': [267], 'whom': [269], 'it': [270, 303], 'appears': [271], 'common': [275], 'disorder.': [276], 'Haematologically,': [277], 'Indians': [281, 301], 'than': [284], 'seen': [286, 334], 'Chinese': [288, 316], 'fact': [291], "Bart's": [294], 'hydrops': [295], 'fetalis': [296], 'does': [297], 'not': [298], 'occur': [299], 'makes': [302], 'likely': [304], 'genetics': [307], 'differ': [311], 'those': [313], 'possible': [319], 'genetic': [320], 'model': [321], 'discussed': [326], 'identification': [329], 'homozygote': [332], 'as': [335], 'step': [338], 'determination': [341], 'underlying': [344], 'molecular': [345], 'defect.': [346]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2059798805', 'counts_by_year': [{'year': 2014, 'cited_by_count': 1}], 'updated_date': '2025-01-18T01:30:19.292843', 'created_date': '2016-06-24'}