Title: Trisomy 5 in two cases of acute monocytic leukemia with hyperdiploid clones
Abstract: Although numerical chromosomal aberrations are commonly seen in acute myeloid leukemia (AML), trisomy 5 (+5) is very rarely detected. We report two patients, both of whom suffered from acute monocytic leukemia, in which +5 was found in hyperdiploid clones. A review of the English literature shows 17 additional cases of AML with +5 in at least one of the abnormal clones, making a total of 19 such cases including ours. Trisomy 5 has been reported in all FAB subtypes of AML except acute promyelocytic leukemia. In the 19 cases identified in this report, +5 was found in association with other numerical changes (four cases), structural changes (five cases) or both (eight cases). Trisomy 5 as a sole karyotypic abnormality was exceedingly rare (two cases). Its biologic and prognostic significance remains to be determined.
Publication Year: 1998
Publication Date: 1998-10-01
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 5
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