Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia

Name: Work Video:
Duration: 3 min 30 s
Marko Škrtić; Shrivani Sriskanthadevan; Bozhena Jhas; Marinella Gebbia; Xiaoming Wang; Zezhou Wang; Rose Hurren; Yulia Jitkova; Marcela Gronda; Neil MacLean; Courteney K. Lai; Yanina Eberhard; Justyna Bartoszko; Paul A. Spagnuolo; Angela C. Rutledge; Alessandro Datti; Troy Ketela; Jason Moffat; Brian H. Robinson; Jessie Cameron; Jeffery L. Wrana; Connie J. Eaves; Mark D. Minden; Jean Wang; John E. Dick; R. Keith Humphries; Corey Nislow; Guri Giaever; Aaron D. Schimmer
{'id': 'https://openalex.org/W2059613997', 'doi': 'https://doi.org/10.1016/j.ccr.2011.10.015', 'title': 'Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia', 'display_name': 'Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia', 'publication_year': 2011, 'publication_date': '2011-11-01', 'ids': {'openalex': 'https://openalex.org/W2059613997', 'doi': 'https://doi.org/10.1016/j.ccr.2011.10.015', 'mag': '2059613997', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22094260', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3221282'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.ccr.2011.10.015', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25671836', 'display_name': 'Cancer Cell', 'issn_l': '1535-6108', 'issn': ['1535-6108', '1878-3686'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1016/j.ccr.2011.10.015', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5056626774', 'display_name': 'Marko Škrtić', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I112260969', 'display_name': 'Ontario Institute for Cancer Research', 'ror': 'https://ror.org/043q8yx54', 'country_code': 'CA', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I112260969']}, {'id': 'https://openalex.org/I2802654988', 'display_name': 'Princess Margaret Cancer Centre', 'ror': 'https://ror.org/03zayce58', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325899441', 'https://openalex.org/I2802654988']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Marko Škrtić', 'raw_affiliation_strings': ['Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada'], 'affiliations': [{'raw_affiliation_string': 'Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada', 'institution_ids': ['https://openalex.org/I112260969', 'https://openalex.org/I2802654988']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112469949', 'display_name': 'Shrivani Sriskanthadevan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I112260969', 'display_name': 'Ontario Institute for Cancer Research', 'ror': 'https://ror.org/043q8yx54', 'country_code': 'CA', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I112260969']}, {'id': 'https://openalex.org/I2802654988', 'display_name': 'Princess Margaret Cancer Centre', 'ror': 'https://ror.org/03zayce58', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325899441', 'https://openalex.org/I2802654988']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Shrivani Sriskanthadevan', 'raw_affiliation_strings': ['Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada'], 'affiliations': [{'raw_affiliation_string': 'Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada', 'institution_ids': ['https://openalex.org/I112260969', 'https://openalex.org/I2802654988']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065911545', 'display_name': 'Bozhena Jhas', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I112260969', 'display_name': 'Ontario Institute for Cancer Research', 'ror': 'https://ror.org/043q8yx54', 'country_code': 'CA', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I112260969']}, {'id': 'https://openalex.org/I2802654988', 'display_name': 'Princess Margaret Cancer Centre', 'ror': 'https://ror.org/03zayce58', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325899441', 'https://openalex.org/I2802654988']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Bozhena Jhas', 'raw_affiliation_strings': ['Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada'], 'affiliations': [{'raw_affiliation_string': 'Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada', 'institution_ids': ['https://openalex.org/I112260969', 'https://openalex.org/I2802654988']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091821428', 'display_name': 'Marinella Gebbia', 'orcid': 'https://orcid.org/0000-0002-2550-2141'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Marinella Gebbia', 'raw_affiliation_strings': ['Department of Molecular Genetics, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100377916', 'display_name': 'Xiaoming Wang', 'orcid': 'https://orcid.org/0000-0003-4559-7413'}, 'institutions': [{'id': 'https://openalex.org/I112260969', 'display_name': 'Ontario Institute for Cancer Research', 'ror': 'https://ror.org/043q8yx54', 'country_code': 'CA', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I112260969']}, {'id': 'https://openalex.org/I2802654988', 'display_name': 'Princess Margaret Cancer Centre', 'ror': 'https://ror.org/03zayce58', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325899441', 'https://openalex.org/I2802654988']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Xiaoming Wang', 'raw_affiliation_strings': ['Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada'], 'affiliations': [{'raw_affiliation_string': 'Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada', 'institution_ids': ['https://openalex.org/I112260969', 'https://openalex.org/I2802654988']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5115591143', 'display_name': 'Zezhou Wang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I112260969', 'display_name': 'Ontario Institute for Cancer Research', 'ror': 'https://ror.org/043q8yx54', 'country_code': 'CA', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I112260969']}, {'id': 'https://openalex.org/I2802654988', 'display_name': 'Princess Margaret Cancer Centre', 'ror': 'https://ror.org/03zayce58', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325899441', 'https://openalex.org/I2802654988']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Zezhou Wang', 'raw_affiliation_strings': ['Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada'], 'affiliations': [{'raw_affiliation_string': 'Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada', 'institution_ids': ['https://openalex.org/I112260969', 'https://openalex.org/I2802654988']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028072253', 'display_name': 'Rose Hurren', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I112260969', 'display_name': 'Ontario Institute for Cancer Research', 'ror': 'https://ror.org/043q8yx54', 'country_code': 'CA', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I112260969']}, {'id': 'https://openalex.org/I2802654988', 'display_name': 'Princess Margaret Cancer Centre', 'ror': 'https://ror.org/03zayce58', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325899441', 'https://openalex.org/I2802654988']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Rose Hurren', 'raw_affiliation_strings': ['Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada'], 'affiliations': [{'raw_affiliation_string': 'Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada', 'institution_ids': ['https://openalex.org/I112260969', 'https://openalex.org/I2802654988']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019943792', 'display_name': 'Yulia Jitkova', 'orcid': 'https://orcid.org/0000-0003-1252-0604'}, 'institutions': [{'id': 'https://openalex.org/I112260969', 'display_name': 'Ontario Institute for Cancer Research', 'ror': 'https://ror.org/043q8yx54', 'country_code': 'CA', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I112260969']}, {'id': 'https://openalex.org/I2802654988', 'display_name': 'Princess Margaret Cancer Centre', 'ror': 'https://ror.org/03zayce58', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325899441', 'https://openalex.org/I2802654988']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Yulia Jitkova', 'raw_affiliation_strings': ['Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada'], 'affiliations': [{'raw_affiliation_string': 'Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada', 'institution_ids': ['https://openalex.org/I112260969', 'https://openalex.org/I2802654988']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069066501', 'display_name': 'Marcela Gronda', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I112260969', 'display_name': 'Ontario Institute for Cancer Research', 'ror': 'https://ror.org/043q8yx54', 'country_code': 'CA', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I112260969']}, {'id': 'https://openalex.org/I2802654988', 'display_name': 'Princess Margaret Cancer Centre', 'ror': 'https://ror.org/03zayce58', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325899441', 'https://openalex.org/I2802654988']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Marcela Gronda', 'raw_affiliation_strings': ['Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada'], 'affiliations': [{'raw_affiliation_string': 'Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada', 'institution_ids': ['https://openalex.org/I112260969', 'https://openalex.org/I2802654988']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108237687', 'display_name': 'Neil MacLean', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I112260969', 'display_name': 'Ontario Institute for Cancer Research', 'ror': 'https://ror.org/043q8yx54', 'country_code': 'CA', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I112260969']}, {'id': 'https://openalex.org/I2802654988', 'display_name': 'Princess Margaret Cancer Centre', 'ror': 'https://ror.org/03zayce58', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325899441', 'https://openalex.org/I2802654988']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Neil Maclean', 'raw_affiliation_strings': ['Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada'], 'affiliations': [{'raw_affiliation_string': 'Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada', 'institution_ids': ['https://openalex.org/I112260969', 'https://openalex.org/I2802654988']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112243263', 'display_name': 'Courteney K. Lai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1289530486', 'display_name': 'BC Cancer Agency', 'ror': 'https://ror.org/03sfybe47', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1289530486']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Courteney\xa0K. Lai', 'raw_affiliation_strings': ['Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada'], 'affiliations': [{'raw_affiliation_string': 'Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada', 'institution_ids': ['https://openalex.org/I1289530486']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051742442', 'display_name': 'Yanina Eberhard', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I112260969', 'display_name': 'Ontario Institute for Cancer Research', 'ror': 'https://ror.org/043q8yx54', 'country_code': 'CA', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I112260969']}, {'id': 'https://openalex.org/I2802654988', 'display_name': 'Princess Margaret Cancer Centre', 'ror': 'https://ror.org/03zayce58', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325899441', 'https://openalex.org/I2802654988']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Yanina Eberhard', 'raw_affiliation_strings': ['Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada'], 'affiliations': [{'raw_affiliation_string': 'Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada', 'institution_ids': ['https://openalex.org/I112260969', 'https://openalex.org/I2802654988']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077960444', 'display_name': 'Justyna Bartoszko', 'orcid': 'https://orcid.org/0000-0002-0738-0451'}, 'institutions': [{'id': 'https://openalex.org/I2802654988', 'display_name': 'Princess Margaret Cancer Centre', 'ror': 'https://ror.org/03zayce58', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325899441', 'https://openalex.org/I2802654988']}, {'id': 'https://openalex.org/I112260969', 'display_name': 'Ontario Institute for Cancer Research', 'ror': 'https://ror.org/043q8yx54', 'country_code': 'CA', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I112260969']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Justyna Bartoszko', 'raw_affiliation_strings': ['Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada'], 'affiliations': [{'raw_affiliation_string': 'Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada', 'institution_ids': ['https://openalex.org/I2802654988', 'https://openalex.org/I112260969']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086081617', 'display_name': 'Paul A. Spagnuolo', 'orcid': 'https://orcid.org/0000-0002-2431-4368'}, 'institutions': [{'id': 'https://openalex.org/I2802654988', 'display_name': 'Princess Margaret Cancer Centre', 'ror': 'https://ror.org/03zayce58', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325899441', 'https://openalex.org/I2802654988']}, {'id': 'https://openalex.org/I112260969', 'display_name': 'Ontario Institute for Cancer Research', 'ror': 'https://ror.org/043q8yx54', 'country_code': 'CA', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I112260969']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Paul Spagnuolo', 'raw_affiliation_strings': ['Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada'], 'affiliations': [{'raw_affiliation_string': 'Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada', 'institution_ids': ['https://openalex.org/I2802654988', 'https://openalex.org/I112260969']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022325715', 'display_name': 'Angela C. Rutledge', 'orcid': 'https://orcid.org/0000-0001-9106-316X'}, 'institutions': [{'id': 'https://openalex.org/I112260969', 'display_name': 'Ontario Institute for Cancer Research', 'ror': 'https://ror.org/043q8yx54', 'country_code': 'CA', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I112260969']}, {'id': 'https://openalex.org/I2802654988', 'display_name': 'Princess Margaret Cancer Centre', 'ror': 'https://ror.org/03zayce58', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325899441', 'https://openalex.org/I2802654988']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Angela\xa0C. Rutledge', 'raw_affiliation_strings': ['Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada'], 'affiliations': [{'raw_affiliation_string': 'Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada', 'institution_ids': ['https://openalex.org/I112260969', 'https://openalex.org/I2802654988']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018005429', 'display_name': 'Alessandro Datti', 'orcid': 'https://orcid.org/0000-0001-6824-7382'}, 'institutions': [{'id': 'https://openalex.org/I1291836623', 'display_name': 'Mount Sinai Hospital', 'ror': 'https://ror.org/05deks119', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1291836623', 'https://openalex.org/I4210130843']}, {'id': 'https://openalex.org/I210557978', 'display_name': 'Lunenfeld-Tanenbaum Research Institute', 'ror': 'https://ror.org/01s5axj25', 'country_code': 'CA', 'type': 'facility', 'lineage': ['https://openalex.org/I1291836623', 'https://openalex.org/I210557978', 'https://openalex.org/I4210130843']}, {'id': 'https://openalex.org/I27483092', 'display_name': 'University of Perugia', 'ror': 'https://ror.org/00x27da85', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I27483092']}], 'countries': ['CA', 'IT'], 'is_corresponding': False, 'raw_author_name': 'Alessandro Datti', 'raw_affiliation_strings': ['Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06126 Perugia, Italy', 'Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada'], 'affiliations': [{'raw_affiliation_string': 'Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada', 'institution_ids': ['https://openalex.org/I1291836623', 'https://openalex.org/I210557978']}, {'raw_affiliation_string': 'Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06126 Perugia, Italy', 'institution_ids': ['https://openalex.org/I27483092']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022318607', 'display_name': 'Troy Ketela', 'orcid': 'https://orcid.org/0000-0003-4732-6553'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Troy Ketela', 'raw_affiliation_strings': ['Department of Molecular Genetics, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086112491', 'display_name': 'Jason Moffat', 'orcid': 'https://orcid.org/0000-0002-5663-8586'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Jason Moffat', 'raw_affiliation_strings': ['Department of Molecular Genetics, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111850073', 'display_name': 'Brian H. Robinson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801317318', 'display_name': 'Hospital for Sick Children', 'ror': 'https://ror.org/057q4rt57', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801317318']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Brian\xa0H. Robinson', 'raw_affiliation_strings': ['Genetics and Genome Biology, The Research Institute, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada'], 'affiliations': [{'raw_affiliation_string': 'Genetics and Genome Biology, The Research Institute, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada', 'institution_ids': ['https://openalex.org/I2801317318']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109572749', 'display_name': 'Jessie Cameron', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801317318', 'display_name': 'Hospital for Sick Children', 'ror': 'https://ror.org/057q4rt57', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801317318']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Jessie\xa0H. Cameron', 'raw_affiliation_strings': ['Genetics and Genome Biology, The Research Institute, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada'], 'affiliations': [{'raw_affiliation_string': 'Genetics and Genome Biology, The Research Institute, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada', 'institution_ids': ['https://openalex.org/I2801317318']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020461161', 'display_name': 'Jeffery L. Wrana', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1291836623', 'display_name': 'Mount Sinai Hospital', 'ror': 'https://ror.org/05deks119', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1291836623', 'https://openalex.org/I4210130843']}, {'id': 'https://openalex.org/I210557978', 'display_name': 'Lunenfeld-Tanenbaum Research Institute', 'ror': 'https://ror.org/01s5axj25', 'country_code': 'CA', 'type': 'facility', 'lineage': ['https://openalex.org/I1291836623', 'https://openalex.org/I210557978', 'https://openalex.org/I4210130843']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Jeffery Wrana', 'raw_affiliation_strings': ['Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada'], 'affiliations': [{'raw_affiliation_string': 'Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada', 'institution_ids': ['https://openalex.org/I1291836623', 'https://openalex.org/I210557978']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009814106', 'display_name': 'Connie J. Eaves', 'orcid': 'https://orcid.org/0000-0002-3452-1926'}, 'institutions': [{'id': 'https://openalex.org/I1289530486', 'display_name': 'BC Cancer Agency', 'ror': 'https://ror.org/03sfybe47', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1289530486']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Connie\xa0J. Eaves', 'raw_affiliation_strings': ['Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada'], 'affiliations': [{'raw_affiliation_string': 'Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada', 'institution_ids': ['https://openalex.org/I1289530486']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026397928', 'display_name': 'Mark D. Minden', 'orcid': 'https://orcid.org/0000-0002-9089-8816'}, 'institutions': [{'id': 'https://openalex.org/I112260969', 'display_name': 'Ontario Institute for Cancer Research', 'ror': 'https://ror.org/043q8yx54', 'country_code': 'CA', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I112260969']}, {'id': 'https://openalex.org/I2802654988', 'display_name': 'Princess Margaret Cancer Centre', 'ror': 'https://ror.org/03zayce58', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325899441', 'https://openalex.org/I2802654988']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Mark\xa0D. Minden', 'raw_affiliation_strings': ['Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada'], 'affiliations': [{'raw_affiliation_string': 'Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada', 'institution_ids': ['https://openalex.org/I112260969', 'https://openalex.org/I2802654988']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048739197', 'display_name': 'Jean Wang', 'orcid': 'https://orcid.org/0000-0001-7543-3917'}, 'institutions': [{'id': 'https://openalex.org/I112260969', 'display_name': 'Ontario Institute for Cancer Research', 'ror': 'https://ror.org/043q8yx54', 'country_code': 'CA', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I112260969']}, {'id': 'https://openalex.org/I2802654988', 'display_name': 'Princess Margaret Cancer Centre', 'ror': 'https://ror.org/03zayce58', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325899441', 'https://openalex.org/I2802654988']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Jean\xa0C.Y. Wang', 'raw_affiliation_strings': ['Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada', 'Division of Stem Cell and Developmental Biology, Campbell Family Institute for Cancer Research, Ontario Cancer Institute, Toronto, Ontario M5G 1L7, Canada'], 'affiliations': [{'raw_affiliation_string': 'Division of Stem Cell and Developmental Biology, Campbell Family Institute for Cancer Research, Ontario Cancer Institute, Toronto, Ontario M5G 1L7, Canada', 'institution_ids': ['https://openalex.org/I112260969']}, {'raw_affiliation_string': 'Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada', 'institution_ids': ['https://openalex.org/I112260969', 'https://openalex.org/I2802654988']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090356933', 'display_name': 'John E. Dick', 'orcid': 'https://orcid.org/0000-0002-9527-8317'}, 'institutions': [{'id': 'https://openalex.org/I112260969', 'display_name': 'Ontario Institute for Cancer Research', 'ror': 'https://ror.org/043q8yx54', 'country_code': 'CA', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I112260969']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'John\xa0E. Dick', 'raw_affiliation_strings': ['Division of Stem Cell and Developmental Biology, Campbell Family Institute for Cancer Research, Ontario Cancer Institute, Toronto, Ontario M5G 1L7, Canada'], 'affiliations': [{'raw_affiliation_string': 'Division of Stem Cell and Developmental Biology, Campbell Family Institute for Cancer Research, Ontario Cancer Institute, Toronto, Ontario M5G 1L7, Canada', 'institution_ids': ['https://openalex.org/I112260969']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024703985', 'display_name': 'R. Keith Humphries', 'orcid': 'https://orcid.org/0000-0003-0540-7005'}, 'institutions': [{'id': 'https://openalex.org/I1289530486', 'display_name': 'BC Cancer Agency', 'ror': 'https://ror.org/03sfybe47', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1289530486']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Keith Humphries', 'raw_affiliation_strings': ['Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada'], 'affiliations': [{'raw_affiliation_string': 'Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada', 'institution_ids': ['https://openalex.org/I1289530486']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069396293', 'display_name': 'Corey Nislow', 'orcid': 'https://orcid.org/0000-0002-4016-8874'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Corey Nislow', 'raw_affiliation_strings': ['Department of Molecular Genetics, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027866777', 'display_name': 'Guri Giaever', 'orcid': 'https://orcid.org/0000-0003-2437-8414'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Guri Giaever', 'raw_affiliation_strings': ['Department of Molecular Genetics, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5045250493', 'display_name': 'Aaron D. Schimmer', 'orcid': 'https://orcid.org/0000-0003-4023-3899'}, 'institutions': [{'id': 'https://openalex.org/I112260969', 'display_name': 'Ontario Institute for Cancer Research', 'ror': 'https://ror.org/043q8yx54', 'country_code': 'CA', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I112260969']}, {'id': 'https://openalex.org/I2802654988', 'display_name': 'Princess Margaret Cancer Centre', 'ror': 'https://ror.org/03zayce58', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325899441', 'https://openalex.org/I2802654988']}], 'countries': ['CA'], 'is_corresponding': True, 'raw_author_name': 'Aaron\xa0D. Schimmer', 'raw_affiliation_strings': ['Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada'], 'affiliations': [{'raw_affiliation_string': 'Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada', 'institution_ids': ['https://openalex.org/I112260969', 'https://openalex.org/I2802654988']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 8, 'corresponding_author_ids': ['https://openalex.org/A5045250493'], 'corresponding_institution_ids': ['https://openalex.org/I112260969', 'https://openalex.org/I2802654988'], 'apc_list': {'value': 9080, 'currency': 'USD', 'value_usd': 9080, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 7.775, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 603, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '20', 'issue': '5', 'first_page': '674', 'last_page': '688'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11736', 'display_name': 'Histone Deacetylase Inhibitors Research', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11736', 'display_name': 'Histone Deacetylase Inhibitors Research', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10309', 'display_name': 'Acute Myeloid Leukemia Research', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tigecycline', 'display_name': 'Tigecycline', 'score': 0.744545}, {'id': 'https://openalex.org/keywords/hl60', 'display_name': 'HL60', 'score': 0.43931767}], 'concepts': [{'id': 'https://openalex.org/C2778729363', 'wikidata': 'https://www.wikidata.org/wiki/Q11688946', 'display_name': 'Myeloid leukemia', 'level': 2, 'score': 0.77226007}, {'id': 'https://openalex.org/C2777027569', 'wikidata': 'https://www.wikidata.org/wiki/Q420595', 'display_name': 'Tigecycline', 'level': 3, 'score': 0.744545}, {'id': 'https://openalex.org/C2778461978', 'wikidata': 'https://www.wikidata.org/wiki/Q29496', 'display_name': 'Leukemia', 'level': 2, 'score': 0.56157595}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5290374}, {'id': 'https://openalex.org/C28859421', 'wikidata': 'https://www.wikidata.org/wiki/Q39572', 'display_name': 'Mitochondrion', 'level': 2, 'score': 0.50496227}, {'id': 'https://openalex.org/C109159458', 'wikidata': 'https://www.wikidata.org/wiki/Q919283', 'display_name': 'Haematopoiesis', 'level': 3, 'score': 0.49851942}, {'id': 'https://openalex.org/C2779282312', 'wikidata': 'https://www.wikidata.org/wiki/Q1956561', 'display_name': 'Myeloid', 'level': 2, 'score': 0.48942867}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.48589677}, {'id': 'https://openalex.org/C149364088', 'wikidata': 'https://www.wikidata.org/wiki/Q185917', 'display_name': 'Translation (biology)', 'level': 4, 'score': 0.48381418}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.45653564}, {'id': 'https://openalex.org/C2778903051', 'wikidata': 'https://www.wikidata.org/wiki/Q5630035', 'display_name': 'HL60', 'level': 3, 'score': 0.43931767}, {'id': 'https://openalex.org/C201750760', 'wikidata': 'https://www.wikidata.org/wiki/Q1896218', 'display_name': 'Progenitor cell', 'level': 3, 'score': 0.41824552}, {'id': 'https://openalex.org/C2777229759', 'wikidata': 'https://www.wikidata.org/wiki/Q6881848', 'display_name': 'Mitochondrial biogenesis', 'level': 3, 'score': 0.41420448}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.40317988}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.37549692}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3623183}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3324833}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2138147}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.15952083}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.13220778}, {'id': 'https://openalex.org/C105580179', 'wikidata': 'https://www.wikidata.org/wiki/Q188928', 'display_name': 'Messenger RNA', 'level': 3, 'score': 0.11730459}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.106734276}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D050259', 'descriptor_name': 'Genes, Mitochondrial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D007938', 'descriptor_name': 'Leukemia', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D008911', 'descriptor_name': 'Minocycline', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D014176', 'descriptor_name': 'Protein Biosynthesis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007938', 'descriptor_name': 'Leukemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008911', 'descriptor_name': 'Minocycline', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008911', 'descriptor_name': 'Minocycline', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024101', 'descriptor_name': 'Mitochondrial Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024101', 'descriptor_name': 'Mitochondrial Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010444', 'descriptor_name': 'Peptide Elongation Factor Tu', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010444', 'descriptor_name': 'Peptide Elongation Factor Tu', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014176', 'descriptor_name': 'Protein Biosynthesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D000078304', 'descriptor_name': 'Tigecycline', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.ccr.2011.10.015', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25671836', 'display_name': 'Cancer Cell', 'issn_l': '1535-6108', 'issn': ['1535-6108', '1878-3686'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3221282', 'pdf_url': 'https://europepmc.org/articles/pmc3221282?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221282', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22094260', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.ccr.2011.10.015', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25671836', 'display_name': 'Cancer Cell', 'issn_l': '1535-6108', 'issn': ['1535-6108', '1878-3686'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.77, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 52, 'referenced_works': ['https://openalex.org/W1494279257', 'https://openalex.org/W1577790096', 'https://openalex.org/W1579386532', 'https://openalex.org/W1963335440', 'https://openalex.org/W1963535936', 'https://openalex.org/W1964702497', 'https://openalex.org/W1965105249', 'https://openalex.org/W1965392584', 'https://openalex.org/W1966000107', 'https://openalex.org/W1977008237', 'https://openalex.org/W1979421565', 'https://openalex.org/W1982503419', 'https://openalex.org/W1983269321', 'https://openalex.org/W1986908018', 'https://openalex.org/W1989303098', 'https://openalex.org/W1989805167', 'https://openalex.org/W2001932120', 'https://openalex.org/W2009886857', 'https://openalex.org/W2014031830', 'https://openalex.org/W2016254453', 'https://openalex.org/W2021565484', 'https://openalex.org/W2023518810', 'https://openalex.org/W2023728706', 'https://openalex.org/W2023807793', 'https://openalex.org/W2031759349', 'https://openalex.org/W2036973733', 'https://openalex.org/W2037255193', 'https://openalex.org/W2043436613', 'https://openalex.org/W2052607700', 'https://openalex.org/W2054987125', 'https://openalex.org/W2072451938', 'https://openalex.org/W2076279677', 'https://openalex.org/W2078807391', 'https://openalex.org/W2088253442', 'https://openalex.org/W2089170572', 'https://openalex.org/W2090982381', 'https://openalex.org/W2108260765', 'https://openalex.org/W2116817481', 'https://openalex.org/W2119654713', 'https://openalex.org/W2120656656', 'https://openalex.org/W2122347701', 'https://openalex.org/W2124966133', 'https://openalex.org/W2131504509', 'https://openalex.org/W2142437744', 'https://openalex.org/W2150324756', 'https://openalex.org/W2151234721', 'https://openalex.org/W2153851191', 'https://openalex.org/W2156241187', 'https://openalex.org/W2157622488', 'https://openalex.org/W2161128788', 'https://openalex.org/W2271272206', 'https://openalex.org/W4385970358'], 'related_works': ['https://openalex.org/W4283690075', 'https://openalex.org/W4282914905', 'https://openalex.org/W2982691941', 'https://openalex.org/W287175446', 'https://openalex.org/W2167799351', 'https://openalex.org/W2128091727', 'https://openalex.org/W2054016576', 'https://openalex.org/W2012639655', 'https://openalex.org/W1996273713', 'https://openalex.org/W1975868175'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2059613997', 'counts_by_year': [{'year': 2024, 'cited_by_count': 38}, {'year': 2023, 'cited_by_count': 60}, {'year': 2022, 'cited_by_count': 57}, {'year': 2021, 'cited_by_count': 76}, {'year': 2020, 'cited_by_count': 74}, {'year': 2019, 'cited_by_count': 54}, {'year': 2018, 'cited_by_count': 53}, {'year': 2017, 'cited_by_count': 50}, {'year': 2016, 'cited_by_count': 44}, {'year': 2015, 'cited_by_count': 36}, {'year': 2014, 'cited_by_count': 24}, {'year': 2013, 'cited_by_count': 19}, {'year': 2012, 'cited_by_count': 17}], 'updated_date': '2025-01-08T12:47:00.836510', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
