The C-terminal Region of Human Adipose Triglyceride Lipase Affects Enzyme Activity and Lipid Droplet Binding

Name: Work Video:
Duration: 3 min 30 s
Martina Schweiger; Gabriele Schoiswohl; Achim Lass; Franz P.W. Radner; Guenter Haemmerle; Roland Malli; Wolfgang F. Graier; Irina Cornaciu; Monika Oberer; Robert Salvayre; Judith Fischer; Rudolf Zechner; Robert Zimmermann
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'https://openalex.org/W1701513679'], 'abstract_inverted_index': {'Adipose': [0, 232, 464], 'triglyceride': [1, 233, 465, 483], 'lipase': [2, 234, 466, 537, 4025], '(ATGL)': [3, 235], 'catalyzes': [4, 236], 'the': [5, 9, 23, 60, 67, 83, 110, 124, 150, 155, 175, 187, 190, 215, 226, 237, 241, 255, 292, 299, 315, 342, 356, 382, 387, 407, 419, 422, 447, 458, 540, 911, 915, 1055, 1297, 1304, 1316, 1332, 1339, 1345, 1353, 1357, 1367, 1373, 1384, 1393, 1517, 1540, 1553, 1571, 1574, 1580, 1652, 1729, 1744, 1749, 1823, 1835, 1882, 1949, 1981, 1987, 2004, 2115, 2119, 2200, 2223, 2236, 2309, 2312, 2375, 2474, 2614, 2642, 2665, 2687, 2702, 2709, 2713, 2723, 2734, 2743, 2746, 2753, 2757, 2761, 2841, 2887, 2906, 2981, 2990, 3020, 3055, 3075, 3116, 3121, 3130, 3150, 3192, 3236, 3258, 3271, 3359, 3371, 3384, 3412, 3431, 3468, 3473, 3493, 3522, 3541, 3549, 3563, 3573, 3577, 3607, 3629, 3641, 3684, 3692, 3696, 3709, 3713, 3731, 3766, 3791, 3796, 3803, 3827, 3840, 3860, 3927, 3986, 4019, 4110, 4114, 4126, 4136, 4144, 4148, 4167, 4171, 4187, 4212, 4216, 4224, 4229, 4238, 4248, 4262, 4272, 4279, 4296, 4307, 4316, 4328, 4335, 4353], 'first': [6, 238], 'step': [7, 239], 'in': [8, 66, 143, 200, 207, 240, 298, 375, 432, 439, 539, 627, 815, 909, 1048, 1174, 1303, 1315, 1323, 1344, 1560, 1692, 1723, 1762, 1900, 1917, 1983, 2138, 2180, 2199, 2240, 2287, 2334, 2408, 2453, 2481, 2509, 2683, 2756, 2823, 2853, 2926, 2944, 2958, 2989, 3247, 3250, 3254, 3268, 3375, 3404, 3529, 3540, 3548, 3599, 3606, 3634, 3674, 3691, 3695, 3811, 3826, 3839, 3859, 3948, 3957, 3966, 4012, 4109, 4117, 4143, 4147, 4162, 4186, 4211, 4215, 4352], 'hydrolysis': [10, 242], 'of': [11, 85, 113, 123, 168, 193, 218, 225, 243, 317, 345, 355, 400, 425, 450, 457, 542, 621, 652, 994, 999, 1008, 1058, 1190, 1299, 1335, 1342, 1356, 1372, 1383, 1388, 1398, 1516, 1544, 1573, 1646, 1676, 1681, 1746, 1812, 1834, 1884, 1888, 1894, 1896, 1904, 1907, 1915, 1957, 1963, 1986, 1997, 2003, 2032, 2109, 2118, 2169, 2173, 2190, 2202, 2217, 2221, 2311, 2344, 2377, 2381, 2387, 2389, 2412, 2427, 2444, 2610, 2675, 2704, 2712, 2733, 2760, 2806, 2886, 2908, 2924, 2952, 2954, 2969, 3022, 3049, 3100, 3115, 3126, 3132, 3139, 3195, 3270, 3287, 3386, 3414, 3433, 3444, 3472, 3478, 3495, 3501, 3552, 3562, 3566, 3576, 3609, 3647, 3698, 3712, 3733, 3757, 3769, 3851, 3895, 3898, 3909, 3929, 3994, 3997, 4001, 4080, 4094, 4113, 4132, 4138, 4150, 4170, 4191, 4218, 4231, 4242, 4252, 4264, 4281, 4302, 4310, 4314, 4318, 4327, 4332, 4338], 'triacylglycerol': [12, 244, 535], '(TG)': [13, 245, 536], 'generating': [14, 246], 'diacylglycerol': [15, 247], 'and': [16, 53, 182, 228, 248, 285, 414, 460, 865, 996, 1051, 1084, 1100, 1200, 1307, 1361, 1379, 1402, 1503, 1523, 1566, 1635, 1679, 1760, 1794, 1960, 2021, 2111, 2133, 2160, 2167, 2229, 2243, 2285, 2314, 2330, 2341, 2357, 2404, 2460, 2467, 2588, 2636, 2659, 2686, 2752, 2847, 2861, 2880, 2894, 2947, 3060, 3094, 3102, 3108, 3252, 3289, 3411, 3446, 3480, 3547, 3558, 3582, 3587, 3613, 3618, 3694, 3719, 3724, 3742, 3747, 3778, 3815, 3821, 3835, 3842, 3853, 3865, 3873, 3878, 3917, 4003, 4082, 4087, 4096, 4140, 4146, 4156, 4180, 4189, 4209, 4214, 4334], 'free': [17, 249, 489], 'fatty': [18, 250, 490], 'acids.': [19, 251], 'The': [20, 252, 615, 650, 1433, 1507, 1661, 1708, 1792, 1832, 2252, 2325, 2415, 2425, 2514, 2555, 2865, 2937, 3277, 3700, 3781, 3893, 4090], 'enzyme': [21, 159, 183, 202, 208, 227, 230, 253, 391, 415, 434, 440, 459, 462, 616, 1377, 2005, 3474, 4324], 'requires': [22, 254], 'activator': [24, 256, 992], 'protein': [25, 126, 257, 358, 501, 927, 993, 1819, 1895, 1945, 2342, 2388, 3057, 3154, 3388, 3416, 3435], 'CGI-58': [26, 180, 258, 412, 918, 989, 1000, 1052, 1067, 1196, 1305, 1403, 2018, 2904, 3554, 3752], '(or': [27, 259], 'ABHD5)': [28, 260, 929], 'for': [29, 222, 261, 454, 917, 1296, 1311, 1443, 1807, 1878, 1924, 2105, 2196, 2366, 2419, 2433, 2478, 2511, 2691, 2809, 2820, 3085, 3424, 3615, 3744, 3943, 3961, 3991, 4125], 'full': [30, 262], 'enzymatic': [31, 263, 3804], 'activity.': [32, 160, 231, 264, 392, 463, 3570, 3706], 'Defective': [33, 265, 806], 'ATGL': [34, 68, 117, 170, 195, 219, 266, 300, 349, 402, 427, 451, 807, 912, 995, 1010, 1050, 1175, 1317, 1346, 1400, 1562, 1998, 2033, 2112, 2445, 2465, 2468, 2693, 2738, 3127, 3255, 3445, 3447, 3466, 3520, 3567, 3626, 3648, 3657, 3758, 3763, 3831, 3910, 3930, 3963, 4006, 4158], 'function': [35, 267, 808, 1068, 1365, 3805], 'causes': [36, 268], 'a': [37, 269, 619, 933, 1186, 1294, 1327, 1757, 1901, 1918, 1928, 2026, 2213, 2232, 2288, 2305, 2409, 2527, 2564, 2579, 2589, 2598, 2608, 2698, 2850, 3136, 3140, 3242, 3263, 3300, 3376, 3387, 3397, 3405, 3415, 3425, 3434, 3525, 3663, 3881, 4235, 4286, 4322], 'recessively': [38, 270], 'inherited': [39, 271, 935], 'disorder': [40, 272, 936], 'named': [41, 273], 'neutral': [42, 72, 274, 304, 496, 939], 'lipid': [43, 73, 91, 275, 305, 323, 493, 497, 940, 2724, 3867], 'storage': [44, 74, 276, 306, 498, 941], 'disease': [45, 277, 942], 'that': [46, 70, 78, 154, 174, 214, 278, 302, 310, 386, 406, 446, 3120, 3795, 3915, 3926, 3985, 4176, 4278], 'is': [47, 196, 220, 279, 428, 452, 532, 809, 1060, 1074, 3239, 3282, 3932, 3989, 4178, 4283, 4312], 'characterized': [48, 280, 810, 1076], 'by': [49, 281, 811, 1065, 1077, 1406, 1539, 1551, 1733, 1785, 1799, 1840, 1953, 1992, 2001, 2126, 2146, 2245, 2316, 2337, 2499, 2869, 3074, 3453, 3486, 3935, 4290], 'systemic': [50, 282, 812], 'TG': [51, 140, 283, 372, 543, 813, 1879, 1885, 2122, 2340, 2367, 2378, 2434, 3441, 3496, 3537, 3600, 3636, 3644, 3675, 3735, 3786, 3998, 4014, 4129, 4202, 4299, 4349], 'accumulation': [52, 284, 814], 'myopathy.': [54, 286], 'In': [55, 287, 906, 1171, 2707, 3147, 3233, 3556, 3730, 3829, 4197, 4245, 4261], 'this': [56, 288, 653, 3184], 'study,': [57, 289], 'we': [58, 290, 1337, 3668, 3760, 3855, 4174, 4233, 4320], 'investigated': [59, 291, 1338], 'functional': [61, 293, 1340, 3450], 'defects': [62, 294, 1341, 1360, 3451], 'associated': [63, 295, 931, 1001, 1080, 1178, 3336], 'with': [64, 98, 149, 179, 186, 296, 330, 381, 411, 418, 932, 1002, 1081, 1179, 1194, 1291, 1301, 1309, 1313, 1712, 1738, 1753, 1817, 1912, 1936, 1942, 2007, 2227, 2261, 2395, 2462, 2486, 2502, 2520, 2573, 2630, 2828, 2845, 2921, 2941, 2949, 2974, 3013, 3054, 3112, 3229, 3257, 3337, 3339, 3389, 3417, 3436, 3460, 3506, 3512, 3517, 3524, 3622, 3640, 3683, 3751, 3775, 3790, 3802, 3871, 3973, 4018, 4103, 4206, 4295, 4343], 'mutations': [65, 80, 297, 312, 908, 1047, 1173, 1302, 1314, 1322, 1343, 1548, 3335, 3764], 'gene': [69, 301, 469, 913, 916, 920, 1306, 1347], 'cause': [71, 303, 1053], 'disease.': [75, 307], 'We': [76, 308], 'show': [77, 309], 'these': [79, 135, 311, 367, 1256, 3234], 'lead': [81, 313], 'to': [82, 90, 109, 131, 146, 171, 314, 322, 341, 363, 378, 403, 618, 658, 1184, 1255, 1330, 1366, 1437, 1512, 1717, 1822, 2029, 2162, 2210, 2257, 2492, 2603, 2728, 2834, 2877, 2892, 2997, 3129, 3149, 3284, 3353, 3383, 3430, 3819, 4009, 4247, 4285], 'expression': [84, 316, 1519, 1833, 2116, 3385, 3413, 3432, 3461, 3574, 3710, 3937, 4168], 'either': [86, 318, 2006], 'inactive': [87, 319], 'enzymes': [88, 320, 3919, 4115, 4155], 'localizing': [89, 321], 'droplets': [92, 324, 2496, 2725, 3868], '(LDs)': [93, 325], 'or': [94, 326, 662, 914, 1940, 2012, 3467, 4023], 'enzymatically': [95, 327], 'active': [96, 328, 3590, 3661, 3727, 4183, 4270], 'lipases': [97, 329, 3269], 'defective': [99, 331, 1066, 1195, 3888], 'LD': [100, 332, 1381, 2301, 2331, 2345, 2372, 2400, 2888, 3671, 3820, 3849, 3889, 3979], 'binding.': [101, 333, 3980], 'Additionally,': [102, 334], 'our': [103, 211, 335, 443, 3982], 'studies': [104, 163, 336, 395], 'assign': [105, 337, 1362], 'important': [106, 338, 534, 1364], 'regulatory': [107, 339], 'functions': [108, 340, 990], 'C-terminal': [111, 125, 156, 176, 191, 216, 343, 357, 388, 408, 423, 448, 1370, 1471, 1486, 3278, 3630, 3987, 4111, 4152, 4225, 4292, 4308, 4336], 'part': [112, 177, 344, 409, 3123, 3279, 4112, 4337], 'ATGL.': [114, 346, 3770, 3780, 3995], 'Truncated': [115, 347], 'mutant': [116, 348, 997, 3470, 3779, 3918], 'variants': [118, 350, 2694, 3931, 4159], 'lacking': [119, 351, 3628], '∼220': [120, 352], 'amino': [121, 353, 530, 3355, 3391, 3438, 3530], 'acids': [122, 354, 3392, 3439], 'region': [127, 157, 192, 217, 359, 389, 424, 449, 1371, 3631, 3988, 4226, 4293, 4309], 'do': [128, 360], 'not': [129, 361, 1061, 1177, 3800, 3807, 3933, 4255], 'localize': [130, 362], 'LDs.': [132, 364, 3846], 'Interestingly,': [133, 365], 'however,': [134, 366], 'mutants': [136, 368, 3565, 3627, 3658, 3702, 3832, 3875, 3964], 'exhibit': [137, 369, 3632, 4099], 'substantially': [138, 370, 3882, 3970], 'increased': [139, 166, 371, 398, 3569, 3633, 3705, 3739, 3978, 4201], 'hydrolase': [141, 373, 1886, 2379, 2435, 3497, 3538, 3601, 3637, 3676, 3736, 3787, 4015, 4130, 4203, 4350], 'activity': [142, 374, 1378, 1887, 2380, 2436, 3539, 3602, 3638, 3690, 3737, 3788, 4016, 4131, 4137, 4204, 4230, 4258, 4280, 4317, 4351], 'vitro': [144, 376, 3635, 4013], '(up': [145, 377], '20-fold)': [147, 379], 'compared': [148, 380, 3621, 3639, 3750, 3789, 3972, 4017, 4205, 4294], 'wild-type': [151, 383, 3465, 3518, 3916], 'enzyme,': [152, 189, 384, 421, 4250], 'indicating': [153, 385, 3887], 'suppresses': [158, 229, 390, 461], 'Protein-protein': [161, 393], 'interaction': [162, 181, 394, 413], 'revealed': [164, 396, 3914], 'an': [165, 397, 533, 1363, 1667, 2439, 2899, 3354, 3507], 'binding': [167, 399, 1382, 3890], 'truncated': [169, 401, 3962, 4157], 'CGI-58,': [172, 404, 4193, 4219, 4265], 'suggesting': [173, 405, 3794, 3925], 'interferes': [178, 410], 'activation.': [184, 416], 'Compared': [185, 417, 3516, 3870, 4342], 'human': [188, 420, 1324, 1399, 1409, 1561, 2017, 2464, 3196, 3519, 3553, 4095, 4139, 4249, 4297], 'mouse': [194, 426, 2982, 4020], 'much': [197, 429, 4287], 'less': [198, 430], 'effective': [199, 431], 'suppressing': [201, 433, 4315], 'activity,': [203, 435, 3498], 'implicating': [204, 436], 'species-dependent': [205, 437], 'differences': [206, 438, 3082], 'regulation.': [209, 441], 'Together,': [210, 442, 3981], 'results': [212, 444, 1351, 3940], 'demonstrate': [213, 445], 'essential': [221, 453, 513, 3990], 'proper': [223, 455, 3992], 'localization': [224, 456, 2736, 3768, 3928, 3993], '(ATGL;': [467], 'official': [468], 'symbol:': [470], 'PNPLA2,': [471], 'patatin-like': [472], 'phospholipase': [473, 3198], 'domain': [474, 3138, 3194], 'containing': [475, 1392, 1695, 2182, 2856, 2966, 2977, 2993, 3016, 3135], '2)': [476], '3The': [477], 'abbreviations': [478], 'used': [479, 3669], 'are:': [480], 'ATGL,': [481], 'adipose': [482], 'lipase;': [484, 487], 'HSL,': [485], 'hormone-sensitive': [486, 4024], 'FFA,': [488], 'acids;': [491], 'LD,': [492, 2222], 'droplet(s);': [494], 'NLSD,': [495, 1054], 'disease;': [499], 'PKA,': [500], 'kinase': [502], 'A;': [503], 'TG,': [504, 660, 2191], 'triacylglycerol;': [505], 'BSA,': [506], 'bovine': [507], 'serum': [508, 1699], 'albumin;': [509], 'DMEM,': [510], "Dulbecco's": [511], 'minimal': [512], 'medium;': [514], 'PBS,': [515, 1754], 'phosphate-buffered': [516], 'saline;': [517], 'GST,': [518], 'glutathione': [519], 'S-transferase;': [520], 'YFP,': [521], 'yellow': [522], 'fluorescent': [523, 3857, 3896], 'protein;': [524], 'ELISA,': [525], 'enzyme-linked': [526], 'immunosorbent': [527], 'assay;': [528], 'aa,': [529], 'acid(s).': [531], 'involved': [538], 'mobilization': [541], 'stores': [544], '(1Zimmermann': [545, 1846], 'R.': [546, 554, 566, 581, 591, 605, 630, 638, 762, 764, 832, 872, 882, 896, 955, 1014, 1030, 1221, 1278, 1847, 1855, 1867, 2037, 2053, 2072, 2084, 2086, 2537, 2776, 3321, 4029, 4045], 'Strauss': [547, 631, 1025, 1848, 2048, 4040], 'J.G.': [548, 632, 1026, 1849, 2049, 4041], 'Haemmerle': [549, 633, 1015, 1850, 2038, 2073, 4030], 'G.': [550, 552, 560, 577, 583, 589, 603, 634, 868, 874, 880, 894, 1016, 1020, 1028, 1107, 1113, 1851, 1853, 1861, 2039, 2043, 2051, 2074, 4031, 4035, 4043], 'Schoiswohl': [551, 1019, 1852, 2042, 4034], 'Birner-Gruenberger': [553, 1854], 'Riederer': [555, 1017, 1856, 2040, 4032], 'M.': [556, 601, 668, 830, 844, 848, 892, 965, 967, 1018, 1022, 1146, 1219, 1233, 1237, 1276, 1857, 2041, 2045, 2070, 2535, 2778, 2784, 3208, 3319, 4033, 4037], 'Lass': [557, 578, 635, 753, 869, 1858, 2075], 'A.': [558, 564, 579, 636, 754, 797, 828, 870, 953, 959, 1012, 1105, 1217, 1274, 1859, 1865, 2035, 2076, 3202, 3317, 4027, 4062], 'Neuberger': [559, 1860], 'Eisenhaber': [561, 1862], 'F.': [562, 947, 949, 1132, 1863, 3164], 'Hermetter': [563, 1864], 'Zechner': [565, 604, 763, 895, 1029, 1866, 2052, 2083, 4044], 'Science.': [567, 606, 897, 1868], '2004;': [568, 700, 1869], '306:': [569, 1870], '1383-1386Crossref': [570, 1871], 'PubMed': [571, 610, 645, 680, 708, 746, 776, 801, 838, 860, 901, 984, 1041, 1120, 1138, 1166, 1227, 1249, 1284, 1872, 2064, 2098, 2550, 2800, 3179, 3224, 3327, 4056, 4073], 'Scopus': [572, 611, 646, 681, 709, 747, 777, 802, 839, 861, 902, 985, 1042, 1121, 1139, 1167, 1228, 1250, 1285, 1873, 2065, 2099, 2551, 2801, 3180, 3225, 3328, 4057, 4074], '(1519)': [573, 1874], 'Google': [574, 613, 648, 683, 711, 749, 779, 804, 841, 863, 904, 987, 1044, 1123, 1141, 1169, 1230, 1252, 1287, 1875, 2067, 2101, 2158, 2553, 2803, 3182, 3227, 3330, 4059, 4076], 'Scholar,': [575, 684, 712, 750, 780, 842, 1124, 1142, 1231, 2068, 4060], '2Haemmerle': [576], 'Zimmermann': [580, 637, 761, 871, 1013, 2036, 2085, 4028], 'Gorkiewicz': [582, 873, 1027, 2050, 4042], 'Meyer': [584, 875], 'C.': [585, 593, 784, 820, 876, 884, 945, 1128, 1144, 1157, 1209, 1266, 2078, 2149, 2782, 3309], 'Rozman': [586, 877], 'J.': [587, 666, 669, 697, 735, 765, 818, 878, 963, 971, 973, 1116, 1150, 1153, 1161, 1207, 1264, 2087, 2789, 3204, 3212, 3307, 4068], 'Heldmaier': [588, 879], 'Maier': [590, 881], 'Theussl': [592, 883], 'Eder': [594, 885], 'S.': [595, 796, 886, 1130, 2541], 'Kratky': [596, 887], 'D.': [597, 724, 852, 888, 1241, 4064], 'Wagner': [598, 889], 'E.F.': [599, 890], 'Klingenspor': [600, 891], 'Hoefler': [602, 893], '2006;': [607, 898, 1033, 2056, 2090, 4048, 4070], '312:': [608, 899], '734-737Crossref': [609, 900], '(1018)': [612, 903], 'Scholar).': [614, 649, 805, 905, 988, 1045, 1170, 1253, 1876, 2554, 2804, 4077], 'belongs': [617, 3128], 'family': [620, 654, 3118, 3274], 'patatin': [622, 3137], 'domain-containing': [623], 'proteins': [624, 1837, 3114, 3134, 3479, 3783, 3945], 'originally': [625], 'observed': [626, 1087, 3605, 3682], 'plants': [628], '(3Zechner': [629], 'Curr.': [639], 'Opin.': [640], 'Lipidol.': [641], '2005;': [642, 672, 738], '16:': [643], '333-340Crossref': [644], '(224)': [647], 'members': [651], 'have': [655, 1202], 'been': [656, 1204], 'shown': [657, 3810, 3942, 3956], 'hydrolyze': [659], 'phospholipids,': [661], 'retinyl': [663], 'ester': [664], '(4Gao': [665], 'Simon': [667], 'Invest.': [670], 'Dermatol.': [671, 1134, 1162], '124:': [673], '1259-1266Abstract': [674], 'Full': [675, 677, 703, 705, 741, 743, 771, 773, 979, 981, 1036, 1038, 2059, 2061, 2093, 2095, 2795, 2797, 3219, 3221, 4051, 4053], 'Text': [676, 678, 704, 706, 742, 744, 772, 774, 980, 982, 1037, 1039, 2060, 2062, 2094, 2096, 2796, 2798, 3220, 3222, 4052, 4054], 'PDF': [679, 707, 745, 775, 983, 1040, 2063, 2097, 2799, 3223, 4055], '(31)': [682], '5Jenkins': [685], 'C.M.': [686], 'Mancuso': [687], 'D.J.': [688], 'Yan': [689], 'W.': [690, 730, 1148], 'Sims': [691], 'H.F.': [692], 'Gibson': [693], 'B.': [694, 951], 'Gross': [695], 'R.W.': [696], 'Biol.': [698, 766, 2088, 2154, 2546, 2790], 'Chem.': [699, 767, 2089, 2791], '279:': [701], '48968-48975Abstract': [702], '(681)': [710], '6Lake': [713], 'A.C.': [714], 'Sun': [715], 'Y.': [716], 'Li': [717, 723], 'J.L.': [718, 961], 'Kim': [719], 'J.E.': [720, 732, 790], 'Johnson': [721], 'J.W.': [722], 'Revett': [725], 'T.': [726, 2151], 'Shih': [727], 'H.H.': [728], 'Liu': [729], 'Paulsen': [731], 'Gimeno': [733], 'R.E.': [734], 'Lipid': [736, 2495, 2807, 3651], 'Res.': [737], '46:': [739], '2477-2487Abstract': [740], '(232)': [748], '7Kienesberger': [751], 'P.C.': [752], 'Preiss-Landl': [755], 'K.': [756, 846, 1235, 2780], 'Wolinski': [757], 'H.': [758, 854, 957, 1243, 2082, 3206], 'Kohlwein': [759], 'S.D.': [760], '2008;': [768], '283:': [769], '5908-5917Abstract': [770], '(49)': [778], '8Quistad': [781], 'G.B.': [782], 'Barlow': [783], 'Winrow': [785], 'C.J.': [786], 'Sparks': [787], 'S.E.': [788], 'Casida': [789], 'Proc.': [791], 'Natl.': [792], 'Acad.': [793], 'Sci.': [794], 'U.': [795], '2003;': [798, 2792, 3176], '100:': [799], '7983-7987Crossref': [800], '(121)': [803], 'humans': [816], '(9Fischer': [817, 1206, 1263, 3306], 'Lefevre': [819, 1208, 1265, 3308], 'Morava': [821, 1210, 1267, 3310], 'E.': [822, 1159, 1211, 1268, 3162, 3311], 'Mussini': [823, 1212, 1269, 3312], 'J.M.': [824, 1213, 1270, 3160, 3313], 'Laforet': [825, 1214, 1271, 3314], 'P.': [826, 1024, 1215, 1272, 2047, 2080, 3315, 4039, 4066], 'Negre-Salvayre': [827, 1216, 1273, 3316], 'Lathrop': [829, 966, 1218, 1275, 3318], 'Salvayre': [831, 1220, 1277, 3320], 'Nat.': [833, 1222, 1279, 2544, 3322], 'Genet.': [834, 975, 1223, 1280, 3323], '2007;': [835, 857, 1224, 1246, 1281, 2547, 3324], '39:': [836, 1225, 1282, 3325], '28-30Crossref': [837, 1226, 1283, 3326], '(370)': [840, 1229, 1286, 3329], '10Akiyama': [843, 1232], 'Sakai': [845, 1234], 'Ogawa': [847, 1236], 'McMillan': [849, 1238], 'J.R.': [850, 1239], 'Sawamura': [851, 1240], 'Shimizu': [853, 1242], 'Muscle': [855, 1244], 'Nerve.': [856, 1245], '36:': [858, 1247], '856-859Crossref': [859, 1248], '(72)': [862, 1251], 'Scholar)': [864, 1288, 2102, 2159, 3228, 3331], 'rodents': [866], '(2Haemmerle': [867], 'humans,': [907], 'both': [910, 1049], '(comparative': [919], 'identification-58;': [921], 'also': [922, 1203, 3190, 3604, 3660, 4227], 'known': [923, 1070, 1358, 3230], 'as': [924, 938, 991, 1071, 1293, 1830, 1844, 2304, 2373, 2431, 2742, 2882, 3032, 3067, 3347, 3653, 3672, 3681, 3903, 3905, 3941], 'α/β-hydrolase': [925, 3272], 'fold-containing': [926], '5,': [928], 'are': [930, 1176, 3659], 'rare': [934], 'annotated': [937], '(NLSD)': [943], '(11Lefevre': [944], 'Jobard': [946], 'Caux': [948], 'Bouadjar': [950], 'Karaduman': [952], 'Heilig': [954], 'Lakhdar': [956], 'Wollenberg': [958], 'Verret': [960], 'Weissenbach': [962], 'Ozguc': [964], "Prud'homme": [968], 'J.F.': [969], 'Fischer': [970, 1260, 3303], 'Am.': [972], 'Hum.': [974], '2001;': [976, 1163], '69:': [977], '1002-1012Abstract': [978], '(393)': [986], 'forms': [998], 'NLSD': [1003, 1063, 1290, 1308, 3338], 'completely': [1004], 'lose': [1005], 'their': [1006, 3481, 4151], 'capability': [1007], 'activating': [1009], '(12Lass': [1011, 2034, 4026], 'Schweiger': [1021, 2044, 4036], 'Kienesberger': [1023, 2046, 4038], 'Cell': [1031, 1682, 2054, 2545, 4046], 'Metab.': [1032, 2055, 4047], '3:': [1034, 2057, 4049], '309-319Abstract': [1035, 2058, 4050], '(678)': [1043, 2066, 4058], 'Although': [1046], 'phenotypical': [1056], 'appearance': [1057], 'patients': [1059, 1193], 'identical.': [1062], 'caused': [1064, 3452], '(also': [1069], 'Chanarin-Dorfman': [1072], 'syndrome)': [1073], 'clinically': [1075], 'ichthyosis,': [1078], 'often': [1079], 'mild': [1082], 'myopathy': [1083, 1191, 1310, 3340], 'hepatomegaly.': [1085], 'Other': [1086], 'symptoms': [1088], 'include': [1089], 'ophthalmologic': [1090], 'abnormalities,': [1091], 'hearing': [1092], 'loss,': [1093], 'intestinal': [1094], 'involvement,': [1095], 'short': [1096], 'stature,': [1097], 'mental': [1098], 'retardation,': [1099], 'microcephaly': [1101], '(13Chanarin': [1102], 'I.': [1103, 2539], 'Patel': [1104], 'Slavin': [1106], 'Wills': [1108], 'E.J.': [1109], 'Andrews': [1110], 'T.M.': [1111], 'Stewart': [1112], 'Br.': [1114, 1160], 'Med.': [1115], '1975;': [1117], '1:': [1118], '553-555Crossref': [1119], '(225)': [1122], '14Dorfman': [1125], 'M.L.': [1126], 'Hershko': [1127], 'Eisenberg': [1129], 'Sagher': [1131], 'Arch.': [1133], '1974;': [1135], '110:': [1136], '261-266Crossref': [1137], '(170)': [1140], '15Pena-Penabad': [1143], 'Almagro': [1145], 'Martinez': [1147], 'Garcia-Silva': [1149], 'Del': [1151], 'Pozo': [1152], 'Yebra': [1154], 'M.T.': [1155], 'Sanchez-Manzano': [1156], 'Fonseca': [1158], '144:': [1164], '430-432Crossref': [1165], '(41)': [1168], 'contrast,': [1172, 3830], 'ichthyosis.': [1180], 'Affected': [1181], 'individuals': [1182, 1300, 1312], 'appear': [1183], 'develop': [1185], 'more': [1187, 3589, 3665, 3726, 4182, 4269], 'severe': [1188], 'form': [1189], 'than': [1192, 3591, 3728, 4184, 4271], 'function.': [1197], 'Cardiac': [1198], 'abnormalities': [1199], 'hepatomegaly': [1201], 'described': [1205, 1845, 2432, 2883, 3332, 3475], 'According': [1254], 'divergent': [1257], 'clinical': [1258], 'phenotypes,': [1259], 'et': [1261, 3304], 'al.': [1262, 3305], 'proposed': [1289], 'ichthyosis': [1292], 'name': [1295, 3151], 'subgroup': [1298], 'gene.': [1318], 'Because': [1319], 'naturally': [1320], 'occurring': [1321], 'genes': [1325], 'offer': [1326], 'unique': [1328], 'opportunity': [1329], 'study': [1331], 'structure-function': [1333], 'relationship': [1334], 'enzymes,': [1336], 'causing': [1348], 'NLSD.': [1349], 'Our': [1350], 'identify': [1352], 'biochemical': [1354], 'basis': [1355], 'genetic': [1359], 'previously': [1368], 'uncharacterized': [1369], 'protein,': [1374], 'which': [1375, 3428, 4121], 'affects': [1376, 4228], 'mediates': [1380], 'enzyme.': [1385, 3643, 4274], 'cDNA': [1386, 1410, 1413, 1422], 'Cloning': [1387], 'Recombinant': [1389, 1677], 'Proteins—The': [1390], 'sequences': [1391, 1576], 'complete': [1394], 'open': [1395], 'reading': [1396], 'frame': [1397], '(hATGL)': [1401, 2466], 'were': [1404, 1435, 1510, 1549, 1568, 1664, 1690, 1710, 1751, 1797, 1910, 1934, 2023, 2178, 2194, 2225, 2238, 2255, 2302, 2332, 2346, 2393, 2448, 2476, 2497, 2516, 2601, 2680, 2740, 2764, 2818, 2843, 2867, 2890, 2919, 2939, 3052, 3458, 3484, 3504, 3584, 3721, 3773, 3822, 3837, 3920, 3946, 3969, 4160], 'amplified': [1405], 'PCR': [1407, 1508, 1662], 'from': [1408, 1425, 2308, 2620, 2722], 'using': [1411, 1427, 1552, 1579, 1651, 1756, 1828, 2231, 2348, 2438, 2613, 2641, 2664, 2766, 2849, 2898, 3029, 3040, 3065, 3952], 'Advantage': [1412], 'polymerase': [1414], 'mix': [1415], '(BD': [1416, 1525], 'Biosciences': [1417, 1526], 'Clontech,': [1418, 1527], 'Palo': [1419, 1528], 'Alto,': [1420, 1529], 'CA).': [1421, 1530, 1660], 'was': [1423, 1537, 1649, 1731, 1815, 1838, 1951, 1990, 1999, 2124, 2328, 2417, 2429, 2561, 2628, 2654, 2695, 2726, 2987, 3007, 3024, 3038, 3072, 3345, 3422, 3603, 3738, 4007, 4267], 'prepared': [1424, 2125], 'mRNA': [1426], 'SuperScript': [1428], 'Reverse': [1429], 'Transcriptase': [1430], 'protocol': [1431, 1825], '(Invitrogen).': [1432, 1542, 1558], 'primers': [1434], 'designed': [1436], 'create': [1438], 'endonuclease': [1439], 'cleavage': [1440], 'sites': [1441, 1515], '(underlined)': [1442], 'subsequent': [1444], 'cloning': [1445], 'strategies:': [1446], 'hATGL': [1447, 1451, 1474, 1493, 3814, 3852, 3872, 4081, 4185, 4311, 4339], 'HisMaxC': [1448, 1452, 1473, 1488], 'forward,': [1449, 1456, 1462, 1476, 1491, 1498], '5′-CGGGATCCTTTCCCCGCGAGAAGACGTG-3′;': [1450], 'reverse,': [1453, 1459, 1465, 1480, 1495, 1501, 1505], '5′-CCCTCGAGTCACAGCCCCAGGGCCCC-3′;': [1454], 'hATGL_YFP-C1': [1455, 1458], '5′-ATCTCGAGCCACCATGTTTCCCCGCGAGAAGACG-3′;': [1457], '5′-GTGGATCCCGCAGCCCCAGGGCCCCGATCA-3′;': [1460], 'hCGI-58_HisMaxC': [1461, 1464], '5′-AAGGTACCAGCGGCGGAGGAGGAGGAG-3′;': [1463], '5′-CCTCTAGATCAGTCCACAGTGTCGCAGA-3′;': [1466], 'chimeric': [1467, 1482, 4323], 'mN/hC-ATGL': [1468, 4345], '(murine': [1469], 'Nterminal/human': [1470], 'region)': [1472, 1487], 'bp799': [1475, 1490], '5′-GCCCGCCCCCACGGCCCA-3′,': [1477], 'mATGL': [1478, 1489, 4083, 4177, 4207, 4243, 4253, 4282, 4333], 'bp798': [1479, 1494], '5′-TGGGGGCAGTGCCAGCAA-3′,': [1481], 'hNmC-ATGL': [1483], '(human': [1484], 'N-terminal/murine': [1485], '5′-GTTGTCCCCCAGGAAGAGG-3′;': [1492], '5′-GGGGGGCAACGCCAGCAA-3′;': [1496], 'mATGL_HisMaxC': [1497, 1500], '5′-TGGTACCGTTCCCGAGGGAGACCAAGTGGA-3′;': [1499], '5′-CCTCGAGCGCAAGGCGGGAGGCCAGGTG3′;': [1502], 'mATGL289_HisMaxC': [1504], '5′-CCCTCGAGTCTTTGATCCTCCTCTCCAGC-3′.': [1506], 'products': [1509, 1663], 'ligated': [1511], 'compatible': [1513], 'restriction': [1514], 'eukaryotic': [1518], 'vector': [1520, 1534], 'pcDNA4/HisMaxC': [1521], '(Invitrogen)': [1522, 1694, 2508], 'pEYFP-C1': [1524], 'A': [1531, 1632, 1640, 1764, 1909, 2242, 2855, 3292, 3365, 3596], 'control': [1532], 'pcDNA4/HisMax': [1533], 'expressing': [1535, 2015], 'β-galactosidase': [1536], 'provided': [1538], 'manufacturer': [1541], 'Generation': [1543], 'Site-directed': [1545], 'Mutagenesis': [1546], 'Clones—Point': [1547], 'performed': [1550, 1650, 1935, 2765], 'GeneTailor': [1554], 'site-directed': [1555], 'mutagenesis': [1556], 'system': [1557], 'Mutations': [1559], '(P195L,': [1563], 'FS270,': [1564, 1598, 1602, 3580, 3616, 3717, 3745, 3833, 3876], 'FS282,': [1565, 1606, 1610, 3581, 3617, 3718, 3746, 3834, 3877], 'Q289X)': [1567], 'introduced': [1569], 'at': [1570, 1801, 1921, 2025, 2212, 2422, 2633, 2638, 2656, 2661, 2701, 2717, 2750, 3026, 3361, 3378, 3407, 3922], 'positions': [1572], 'coding': [1575], 'indicated': [1577], 'below': [1578], 'following': [1581], 'primer': [1582], 'pairs:': [1583], 'P195L,': [1584, 1591, 3874], '584': [1585, 1592], 'C': [1586, 1593, 1616, 1623, 2928, 2946, 2976, 3015], '→': [1587, 1594, 1617, 1624, 1631, 1639], 'T': [1588, 1595, 1618, 1625], 'forward': [1589, 1600, 1608, 1619, 1633], '5′-CGGGCGAGAGTGACATCTGTCTGCAGGACAGCTC-3′;': [1590], 'reverse': [1596, 1604, 1612, 1626, 1641], '5′-ACAGATGTCACTCTCGCCCGAGAAGGGGGAC-3′;': [1597], '808delC': [1599, 1603], '5′-CGTTGCCCCCCGCCCGCCCCACGGCCCAGAGG-3′;': [1601], '5′GGGCGGGCGGGGGGCAACGCCAGCAAGGGG-3′;': [1605], '847delC': [1607, 1611], '5′-GACCAGGCAGTGGAGAGCGCCAAGCGGAGGATT-3′;': [1609], '5′-GCGCTCTCCACTGCCTGGTCCTTGTCCTCT-3′;': [1613], 'Q289X,': [1614, 1621, 3619, 3748], '865': [1615, 1622], '5′-GCCCAAGCGGAGGATTACTCGTAGCTGCCGGGAGA-3′;': [1620], '5′-GAGTAATCCTCCGCTTGGGCGCTCTCCACT-3′;': [1627], 'S47A,': [1628, 1636], '139': [1629, 1637], 'S': [1630, 1638], '5′-CCACTCACATCTACGGAGCCGCGGCAGGGGCGCT-3′;': [1634], '5′-GGCTCCGTAGATGTGAGTGGCGTTGGCCAC-3′.': [1642], 'Sequence': [1643, 4078], 'Analysis—Sequence': [1644], 'analysis': [1645, 1843, 2897, 3107, 3489, 3908], 'plasmid': [1647], 'DNA': [1648, 1715], 'BigDye': [1653], 'terminator': [1654], 'mixture': [1655], '(Applied': [1656, 1673], 'Biosystems,': [1657], 'Foster': [1658], 'City,': [1659], 'sequenced': [1665], 'on': [1666, 2114, 2450, 2526, 2563, 3370, 3572, 3708, 4166], 'ABI': [1668], 'PRISM': [1669], '310': [1670], 'Genetic': [1671], 'analyzer': [1672], 'Biosystems).': [1674], 'Expression': [1675, 3477], 'Proteins': [1678, 2885], 'Preparation': [1680], 'Extracts—Monkey': [1683], 'embryonic': [1684], 'kidney': [1685], 'cells': [1686, 1709, 1750, 1796, 2193, 2224, 2237, 2447, 2475, 2501, 2515, 2596, 2817, 2842, 2866, 3457, 3503, 3772, 3900], '(Cos-7,': [1687], 'ATCC': [1688], 'CRL1651)': [1689], 'cultivated': [1691], 'DMEM': [1693, 2181, 2510], '10%': [1696, 1739, 2183], 'fetal': [1697, 1740, 2184], 'calf': [1698, 1741, 2185], '(Sigma-Aldrich)': [1700], 'under': [1701, 1931], 'standard': [1702], 'conditions': [1703, 1933], '(37': [1704], '°C,': [1705], '5%': [1706, 2163, 2405, 2942], 'CO2).': [1707], 'transfected': [1711, 2461, 3459, 3774], '1': [1713, 1768, 1771, 1780, 1961, 1984, 2273, 2282, 2420, 2857, 2862, 3344], 'μg': [1714, 1893, 2386, 2923, 2951], 'complexed': [1716, 2209, 2491, 2833], 'Metafectene': [1718], '(Biontex': [1719], 'GmbH,': [1720, 2361], 'Munich,': [1721, 2362], 'Germany)': [1722, 2571, 2774], 'serum-free': [1724], 'DMEM.': [1725], 'After': [1726, 1947, 1974, 2972, 3009], '4': [1727, 1805, 2299, 2323], 'h': [1728, 2198, 2421, 2471, 2480, 2813, 2822], 'medium': [1730, 1736, 2484, 2826], 'replaced': [1732], 'regular': [1734, 2482, 2824], 'growth': [1735, 2483, 2825], 'supplemented': [1737, 2485, 2827], 'serum.': [1742, 2186], 'For': [1743, 2187, 2219, 2673, 3492], 'preparation': [1745], 'cell': [1747, 1758, 1813, 1898, 2233, 2253, 2391, 2851, 2956, 3050, 3949], 'extracts,': [1748], 'washed': [1752, 2226, 2517, 2844], 'collected': [1755, 2230, 2303, 2848], 'scraper,': [1759], 'disrupted': [1761, 2244, 2868], 'buffer': [1763, 1908, 2241, 2262, 2335, 2854, 2927, 2945, 2975, 2992, 3014], '(0.25': [1765], 'm': [1766, 1965, 1969], 'sucrose,': [1767], 'mm': [1769, 1772, 2140, 2204, 2265, 2271, 2274, 2858, 2863, 2930, 2935, 2960], 'EDTA,': [1770, 2275], 'dithiothreitol,': [1773], '20': [1774, 2197, 2276, 2479, 2821], 'μg/ml': [1775, 1778, 1781, 2277, 2280, 2283, 2504], 'leupeptine,': [1776, 2278], '2': [1777, 2175, 2279, 2512, 2719, 3395], 'antipain,': [1779, 2281], 'pepstatin,': [1782], 'pH': [1783, 2268, 2932, 2964], '7.0)': [1784, 2145], 'sonication': [1786, 2147, 2246, 2870], '(Virsonic': [1787, 2247, 2871], '475,': [1788, 2248, 2872], 'Virtis,': [1789, 2249, 2873], 'Gardiner,': [1790, 2250, 2874], 'NJ).': [1791, 2251], 'nuclei': [1793], 'unbroken': [1795], 'removed': [1798], 'centrifugation': [1800, 1975, 2317], '1,000': [1802], '×': [1803, 1977, 2297, 2319, 2457], 'g,': [1804, 1978, 2298, 2320], '°C': [1806, 1923], '10': [1808], 'min.': [1809, 1926], 'Protein': [1810, 3047], 'concentration': [1811, 2027, 3037], 'lysates': [1814, 1938, 2014, 2254, 3500], 'determined': [1816, 1991, 2347, 2430, 3025, 3039, 3073, 3485, 3761], 'Bio-Rad': [1818, 2359], 'assay': [1820, 3058], 'according': [1821], "manufacturer's": [1824], '(Bio-Rad': [1826], '785)': [1827], 'BSA': [1829, 2211, 2407, 2836, 2943, 3066], 'standard.': [1831, 3068], 'His-tagged': [1836, 2016, 2120, 2970, 3464, 3578, 3715, 3792, 3953, 4172], 'detected': [1839, 2637, 2660, 3965], 'Western': [1841, 2810, 2895, 3487, 3906], 'blotting': [1842, 2896, 3488, 3907], 'Assay': [1877, 2365], 'Hydrolase': [1880, 2368, 3442, 3645, 3999, 4300], 'Activity—For': [1881], 'determination': [1883, 2376, 3494], 'various': [1889, 1943, 2382], 'recombinant': [1890, 1944, 2383], 'proteins,': [1891, 2384, 2910, 3235, 3579, 3716], '10–40': [1892], 'respective': [1897, 2390, 2714, 3714], 'extracts': [1899, 2392, 2957, 3051], 'total': [1902, 2410], 'volume': [1903, 2411], '100': [1905, 1913, 2139, 2270, 2611], 'μl': [1906, 1914], 'incubated': [1911, 2195, 2394, 2418, 2477, 2819, 2948, 3505], 'substrate': [1916, 2123, 3510, 3673], 'water': [1919], 'bath': [1920], '37': [1922, 2423], '60': [1925], 'As': [1927, 3809, 3955], 'control,': [1929], 'incubations': [1930], 'identical': [1932], 'LacZ-expressing': [1937], 'alone': [1939], 'mixed': [1941], 'lysates.': [1946], 'incubation,': [1948], 'reaction': [1950, 2416, 3238], 'terminated': [1952], 'adding': [1954], '3.25': [1955], 'ml': [1956, 1962, 1985], 'methanol/chloroform/heptane': [1958], '(10:9:7)': [1959], '0.1': [1964, 1968], 'potassium': [1966, 2141, 2266, 2961], 'carbonate,': [1967], 'boric': [1970], 'acid,': [1971], '(pH': [1972, 2144], '10.5).': [1973], '(800': [1976], '15': [1979, 2321, 2503], 'min),': [1980], 'radioactivity': [1982], 'upper': [1988], 'phase': [1989], 'liquid': [1993], 'scintillation': [1994], 'counting.': [1995], 'Stimulation': [1996], 'achieved': [2000], 'co-incubation': [2002], 'purified': [2008, 3670, 4192], 'murine': [2009, 4097, 4141], 'GST-CGI-58': [2010], '(GST-CGI)': [2011], 'Cos-7': [2013, 2816, 2955, 3456, 3502, 3771, 4163], '(hCGI58).': [2019], 'GST-CGI': [2020, 2925], 'hCGI-58': [2022, 2110, 3610], 'added': [2024, 2988], 'leading': [2028, 3382], 'maximal': [2030], 'stimulation': [2031], '17Schweiger': [2069], 'Schreiber': [2071], 'Fledelius': [2077], 'Jacobsen': [2079], 'Tornqvist': [2081], '281:': [2091], '40236-40241Abstract': [2092], '(516)': [2100], '(300': [2103], 'ng/assay': [2104], 'GST-CGI;': [2106], 'equimolar': [2107, 2967], 'concentrations': [2108, 2968, 3048], 'based': [2113], 'levels': [2117, 3575, 3711, 4169], 'proteins).': [2121], 'emulsifying': [2127], '330': [2128], 'μm': [2129, 2135, 2720], 'triolein': [2130, 3509], '(40,000': [2131], 'cpm/nmol)': [2132], '45': [2134], 'phosphatidylcholine/phosphatidylinositol': [2136], '(3:1)': [2137], 'phosphate': [2142, 2962], 'buffer,': [2143, 2963], '(18Holm': [2148], 'Osterlund': [2150], 'Methods': [2152], 'Mol.': [2153], '1999;': [2155, 3216], '109:': [2156], '109-121PubMed': [2157], 'adjusted': [2161], 'defatted': [2164, 2406], 'BSA.': [2165, 2494, 2995], 'Labeling': [2166], 'Isolation': [2168, 2805], 'LD—Human': [2170], 'skin': [2171], 'fibroblasts': [2172], 'Patient': [2174, 3343, 3394, 3420], '(FS282': [2176], 'mutation)': [2177], 'cultured': [2179], 'radioactive': [2188], 'labeling': [2189], 'confluent': [2192], 'presence': [2201, 3550, 3608, 3697, 3732, 4145, 4190, 4217, 4263], '0.2': [2203], 'oleate': [2205], '(4': [2206], 'mCi': [2207], '3H-9,10-oleate/mmol)': [2208], 'FFA/BSA': [2214], 'molar': [2215], 'ratio': [2216, 2744, 2838, 3884], '3:1.': [2218], 'isolation': [2220], 'PBS': [2228, 2522, 2846], 'scraper.': [2234], 'Thereafter,': [2235, 2840], 'suspended': [2239], 'transferred': [2256, 2876], 'SW41': [2258, 2289, 2878], 'tubes,': [2259, 2879], 'overlaid': [2260], 'B': [2263, 2336], '(50': [2264, 2929], 'phosphate,': [2267], '7.4,': [2269], 'KCl,': [2272], 'pepstatin),': [2284], 'centrifuged': [2286, 2881], 'rotor': [2290], '(Beckman,': [2291], 'Fullerton,': [2292], 'CA)': [2293], '(2': [2294], 'h,': [2295], '100,000': [2296], '°C).': [2300, 2324], 'white': [2306], 'band': [2307], 'top': [2310], 'tubes': [2313], 'concentrated': [2315], '(20,000': [2318], 'min,': [2322], 'underlying': [2326], 'solution': [2327], 'removed,': [2329], 'resuspended': [2333], 'brief': [2338], 'sonication.': [2339], 'contents': [2343], 'commercial': [2349], 'reagents': [2350], '(Thermotrace,': [2351], 'Thermo': [2352], 'Electron': [2353, 3045], 'Corporation,': [2354], 'Victoria,': [2355], 'Australia': [2356], 'Bradford,': [2358], 'Laboratories': [2360], 'Germany,': [2363], 'respectively).': [2364, 4220], 'Activity': [2369, 3443, 3646, 4000, 4301], 'Using': [2370, 3650], 'Purified': [2371], 'Substrate—For': [2374], '40': [2385], '25': [2396], 'nmol': [2397], '3H-9,10-oleate': [2398], 'labeled': [2399], '(1,660': [2401], 'cpm/nmol': [2402], 'TG)': [2403], '200': [2413], 'μl.': [2414], '°C.': [2424], 'release': [2426], 'FFA': [2428], 'assays': [2437, 3677], 'artificial': [2440, 3508, 3685], 'substrate.': [2441], 'Cellular': [2442, 3755], 'Localization': [2443, 3756], 'Mutants—Cos-7': [2446], 'seeded': [2449], 'glass': [2451], 'coverslips': [2452], '6-well': [2454], 'dishes': [2455], '(1.5': [2456], '105': [2458], 'cells/well)': [2459], 'YFP-tagged': [2463, 2692, 3776, 3782, 3944], 'mutants.': [2469], '24': [2470], 'after': [2472, 2814], 'transfection,': [2473, 2815], 'oleic': [2487, 2829], 'acid': [2488, 2830, 3296, 3356, 3531], '(400': [2489, 2831], 'μm)': [2490, 2832], 'fat-free': [2493, 2835], 'stained': [2498], 'incubating': [2500], 'Bodipy®': [2505, 2650], '558/568': [2506, 2651], 'C12': [2507, 2652], 'h.': [2513], 'three': [2518, 2998, 3011], 'times': [2519, 3012], '1×': [2521], 'before': [2523], 'mounting': [2524], 'them': [2525], 'Nipkow®-based': [2528], 'array': [2529, 2556], 'confocal': [2530, 2557], 'laser': [2531, 2558, 2582, 2592], 'scanning': [2532, 2559], 'microscope': [2533, 2560], '(19Trenker': [2534], 'Malli': [2536], 'Fertschai': [2538], 'Levak-Frank': [2540], 'Graier': [2542, 2787], 'W.F.': [2543, 2788], '9:': [2548], '445-452Crossref': [2549], '(284)': [2552], 'built': [2562], 'Zeiss': [2565, 2621], 'Axiovert': [2566], '200M': [2567], '(Zeiss': [2568, 2622], 'Microsystems,': [2569, 2623], 'Jena,': [2570, 2624], 'equipped': [2572], 'VoxCell': [2574], 'Scan®': [2575], '(VisiTech,': [2576], 'Sunderland,': [2577], 'UK),': [2578], '150-milliwatt': [2580], 'Argon': [2581, 2631], '(Laser': [2583], 'Physics;': [2584], 'West': [2585], 'Jordan,': [2586], 'UT),': [2587], '30-milliwatt': [2590], '405-nm': [2591], 'diode': [2593], '(VisiTech).': [2594], 'Single': [2595], 'displaying': [2597], 'clear': [2599], 'fluorescence': [2600, 2627, 2653, 2676, 2689, 2748], 'selected': [2602, 2682], 'acquire': [2604], 'three-dimensional': [2605, 3109, 3231], 'stacks': [2606], '(with': [2607], 'z-distance': [2609], 'nm)': [2612], 'α': [2615], 'Plan-Fluar': [2616], '100×/1.45': [2617], 'oil': [2618], 'objective': [2619], 'Germany).': [2625], 'YFP': [2626, 3797], 'excited': [2629, 2655], 'Laser': [2632], '488': [2634], 'nm': [2635, 2640, 2658, 2663, 3028, 3031], '535': [2639], 'emission': [2643, 2666], 'filter': [2644, 2667], '535AF26': [2645], '(Omega': [2646, 2669], 'Optical,': [2647, 2670], 'Brattleboro,': [2648, 2671], 'VT).': [2649, 2672], '514': [2657], '570': [2662], '570LP': [2668], 'quantification': [2674, 3894], 'signals,': [2677], 'five': [2678], 'LDs': [2679, 2751, 3968], 'randomly': [2681], 'single': [2684, 3366, 3399, 3526], 'cells,': [2685], 'average': [2688, 2710, 2747, 2754], 'intensity': [2690, 2711], 'obtained': [2696, 3947], 'along': [2697], 'circular': [2699, 2715], 'line': [2700, 2716], 'edge': [2703], 'each': [2705], 'droplet.': [2706], 'analogy,': [2708], 'least': [2718], 'away': [2721], 'extracted': [2727], 'measure': [2729], 'LD-free': [2730, 3861], 'cytoplasm.': [2731, 2758], 'Differences': [2732], 'subcellular': [2735], 'different': [2737, 3334, 3454, 3936], 'constructs': [2739, 3911], 'expressed': [2741, 3921, 4161], 'between': [2745], 'intensities': [2749, 2755], 'All': [2759], 'image': [2762], 'analyses': [2763], 'Metamorph': [2767], '5.0': [2768], '(Universal': [2769], 'Imaging,': [2770], 'Visitron': [2771], 'Systems,': [2772], 'Puchheim,': [2773], '(20Malli': [2775], 'Frieden': [2777], 'Osibow': [2779], 'Zoratti': [2781], 'Mayer': [2783], 'Demaurex': [2785], 'N.': [2786], '278:': [2793], '44769-44779Abstract': [2794], '(166)': [2802], 'Droplets': [2808, 3652], 'Blot': [2811], 'Analysis—24': [2812], '(molar': [2837], '3:1).': [2839], 'scraper': [2852], 'phenylmethylsulfonyl': [2859], 'fluoride': [2860], 'EDTA.': [2864], 'NJ),': [2875], 'above.': [2884, 3476], 'fraction': [2889, 3863], 'subjected': [2891], 'SDS-PAGE': [2893], 'anti-His': [2900, 2983], 'antibody': [2901, 2984, 3004], '(GE': [2902, 2985, 3005], 'Healthcare).': [2903], 'ELISA—For': [2905], 'detection': [2907], 'interacting': [2909], 'ELISA': [2911], 'plates': [2912], '(MaxiSorp,': [2913], 'Nalgen': [2914], 'Nunc': [2915], 'Int.,': [2916], 'Rochester,': [2917], 'NY)': [2918], 'coated': [2920], '3': [2922, 3421], 'Tris,': [2931], '8.0,': [2933], '150': [2934], 'NaCl).': [2936], 'wells': [2938], 'blocked': [2940], '50': [2950, 2959], 'protein/well': [2953], '7.0,': [2965], 'proteins.': [2971], 'washing': [2973, 3010], '0.05%': [2978, 3017], 'Tween': [2979, 3018], '20,': [2980, 3019], 'Healthcare)': [2986, 3006], 'same': [2991], '0.5%': [2994], 'Subsequent': [2996], 'further': [2999], 'washes,': [3000], 'horseradish': [3001], 'peroxidase-conjugated': [3002], 'anti-mouse': [3003], 'added.': [3008], 'absorbance': [3021], 'tetramethyl-benzidine': [3023], '450': [3027], '620': [3030], 'reference': [3033], 'wavelength.': [3034], 'Biochemical': [3035], 'Analysis—TG': [3036], 'Infinity': [3041], 'Triglycerides': [3042], 'reagent': [3043, 3062], '(Thermo': [3044], 'Corporation).': [3046], 'measured': [3053], 'Bradford': [3056], '(Bio-Rad)': [3059], 'BCA': [3061], '(Pierce),': [3063], 'respectively,': [3064, 3620, 3749], 'Statistical': [3069], 'Analysis—Statistical': [3070], 'significance': [3071], "Student's": [3076], 'unpaired': [3077], 't': [3078], 'test': [3079], '(two-tailed).': [3080], 'Group': [3081], 'considered': [3083], 'significant': [3084], 'p': [3086, 3090, 3095, 3544], '<': [3087, 3091, 3096], '0.05': [3088], '(*),': [3089], '0.01': [3092], '(**),': [3093], '0.001': [3097], '(***).': [3098], 'Structure': [3099], 'Wild-type': [3101], 'Mutant': [3103], 'Human': [3104, 4002], 'ATGL—Previous': [3105], 'sequence': [3106], 'structural': [3110], 'comparisons': [3111], 'related': [3113], 'PNPLA': [3117], 'showed': [3119, 4346], 'N-terminal': [3122, 4091, 4239, 4329], '(residues': [3124, 3145, 3280], '1–251)': [3125], 'class': [3131], 'α/β': [3133], 'three-layer': [3141], '(α/β/α)': [3142], 'sandwich': [3143], 'architecture': [3144], '10–178).': [3146], 'addition': [3148], 'giving': [3152], 'plant': [3153], 'patatin,': [3155], 'Pat17': [3156], '(21Rydel': [3157], 'T.J.': [3158], 'Williams': [3159], 'Krieger': [3161], 'Moshiri': [3163], 'Stallings': [3165], 'W.C.': [3166], 'Brown': [3167], 'S.M.': [3168], 'Pershing': [3169], 'J.C.': [3170], 'Purcell': [3171], 'J.P.': [3172], 'Alibhai': [3173], 'M.F.': [3174], 'Biochemistry.': [3175], '42:': [3177], '6696-6708Crossref': [3178], '(218)': [3181], 'Scholar),': [3183], 'homologous': [3185], 'superfamily': [3186], '(CATH': [3187], 'code': [3188], '3.40.1090.10)': [3189], 'contains': [3191], 'catalytic': [3193, 3243], 'cytosolic': [3197], 'A2': [3199], '(cPLA2)': [3200], '(22Dessen': [3201], 'Tang': [3203], 'Schmidt': [3205], 'Stahl': [3207], 'Clark': [3209], 'J.D.': [3210], 'Seehra': [3211], 'Somers': [3213], 'W.S.': [3214], 'Cell.': [3215], '97:': [3217], '349-360Abstract': [3218], '(309)': [3226], 'structure.': [3232], 'hydrolytic': [3237], 'mediated': [3240], 'through': [3241], 'serine-aspartate': [3244], 'dyad': [3245], '(Ser47–Asp215': [3246], 'Pat17,': [3248], 'Ser228–Asp548': [3249], 'cPLA2,': [3251], 'Ser47–Asp166': [3253], '(predicted)),': [3256], 'nucleophilic': [3259], 'serine': [3260], 'located': [3261, 3838], 'within': [3262, 3358], 'GXSXG': [3264], 'motif': [3265], 'typically': [3266], 'found': [3267, 4108, 4175], 'fold': [3273], '(Fig.': [3275, 3341, 3490, 3514, 3594, 3678, 3891, 3901, 3912, 4195, 4259], '1a).': [3276, 3342], '250–504)': [3281], 'expected': [3283], 'consist': [3285], 'mostly': [3286], 'α-helical': [3288], 'loop': [3290], 'regions.': [3291], 'hydrophobic': [3293], 'stretch': [3294], '(amino': [3295], '315–360)': [3297], 'potentially': [3298], 'represents': [3299], 'lipid-binding': [3301], 'region.': [3302], 'four': [3333, 3469], 'reported': [3346, 4008, 4127], 'compound': [3348], 'heterozygote.': [3349], 'One': [3350], 'mutation': [3351, 3528], 'led': [3352, 3429], 'exchange': [3357], 'α/β-fold': [3360], 'position': [3362, 3379, 3408, 3532], '195': [3363, 3533], '(P195L).': [3364], 'base': [3367, 3400], 'pair': [3368, 3401], 'deletion': [3369, 3402, 3564], 'second': [3372], 'allele': [3373, 3523], 'resulted': [3374], 'frameshift': [3377, 3406], '270': [3380], '(FS270)': [3381], '319': [3390, 3418], '(aa).': [3393], 'exhibited': [3396, 3535, 3568, 3688, 3704, 3784, 3880, 3977, 4200], 'homozygous': [3398, 3423], 'resulting': [3403], '282': [3409], '(FS282)': [3410], 'aa.': [3419], 'nonsense': [3426], 'mutation,': [3427], '289': [3437, 4240], '(Q289X).': [3440], 'Mutants—To': [3448], 'investigate': [3449, 3655, 4222, 4305], 'mutations,': [3455], 'vectors': [3462], 'encoding': [3463, 4237], 'versions': [3471], 'molecular': [3482], 'weights': [3483], '1b).': [3491], 'cytoplasmic': [3499, 3862], 'emulsified': [3511], 'phospholipids': [3513], '1c).': [3515, 3595], '(hATGL),': [3521], 'missense': [3527], '(P195L)': [3534], 'reduced': [3536], 'absence': [3542, 3693, 4149, 4188, 4213], '(–45%,': [3543], '=': [3545], '0.06)': [3546], '(–87%)': [3551], '(hCGI-58).': [3555], 'contrast': [3557, 4246], 'quite': [3559], 'unexpectedly,': [3560], 'all': [3561], 'Based': [3571, 3707, 4165], 'Q289X': [3583, 3720, 3836, 3879, 4199], '2-,': [3585], '4.5-,': [3586], '8.6-fold': [3588], 'hATGL,': [3592, 3974], 'respectively': [3593, 4194], 'comparable': [3597, 3923], 'increase': [3598], '(1.7-,': [3611], '5.4-,': [3612], '11.6-fold': [3614], 'CGI-58-stimulated': [3623], 'hATGL).': [3624], 'Thus,': [3625], 'full-length': [3642, 4154, 4273], 'Mutants': [3649], 'Substrate—To': [3654], 'whether': [3656, 3762, 4223, 4306], 'against': [3662], 'physiologically': [3664], 'relevant': [3666], 'substrate,': [3667, 3686], '1d).': [3679], 'Similar': [3680, 3939], 'P195L': [3687, 3816, 3976], 'decreased': [3689, 3883, 3971, 4348], 'CGI-58.': [3699], 'other': [3701], 'again': [3703, 3886], '2.0-,': [3722], '7.6-,': [3723], '24.6-fold': [3725], 'hATGL.': [3729, 3754, 4133], 'hCGI-58,': [3734], '1.3-,': [3740], '5.0-,': [3741], '22.3-fold': [3743], 'stimulated': [3753], 'Mutants—Next': [3759], 'affect': [3765, 4256], 'cellular': [3767], 'wildtype': [3777], 'similar': [3785], 'constructs,': [3793, 4173], 'tag': [3798], 'did': [3799, 4254], 'interfere': [3801], '(data': [3806], 'shown).': [3808], 'Fig.': [3812, 3958, 4119], '2a,': [3813], 'mainly': [3817], 'localized': [3818], 'only': [3823], 'barely': [3824, 3843], 'detectable': [3825, 3844], 'cytosol.': [3828], 'cytosol': [3841], 'around': [3845, 3866], 'To': [3847, 4134, 4221], 'compare': [3848, 4135], 'association': [3850], 'mutants,': [3854], 'quantified': [3856], 'signals': [3858, 3897, 3960], '(F-cytoplasm)': [3864], '(F-LD).': [3869], 'F-LD/F-cytoplasm': [3885], '2b).': [3892], 'whole': [3899], '2c)': [3902], 'well': [3904], '2d)': [3913], 'levels,': [3924], 'affected': [3934], 'levels.': [3938], 'fractionation': [3950], 'experiments': [3951], 'constructs.': [3954], '2e,': [3959], 'isolated': [3967], 'whereas': [3975], 'data': [3983, 4276], 'suggest': [3984, 4277], 'Comparison': [3996], 'Mouse': [4004], 'ATGL—Human': [4005], 'possess': [4010], 'low': [4011, 4104, 4128], 'ortholog': [4021], '(mATGL)': [4022], '23Mairal': [4061], 'Langin': [4063], 'Arner': [4065], 'Hoffstedt': [4067], 'Diabetologia.': [4069], '49:': [4071], '1629-1636Crossref': [4072], '(78)': [4075], 'comparison': [4079], 'reveals': [4084], '84%': [4085], 'identity': [4086], '87%': [4088], 'homology.': [4089, 4101], '266': [4092, 4330], 'aa': [4093, 4241, 4331], 'orthologs': [4098, 4142], '96%': [4100], 'Stretches': [4102], 'similarity': [4105], 'can': [4106], 'be': [4107, 4123], '(indicated': [4116], 'red,': [4118], '3a),': 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2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 11}, {'year': 2013, 'cited_by_count': 17}, {'year': 2012, 'cited_by_count': 13}], 'updated_date': '2025-01-04T19:19:31.621658', 'created_date': '2016-06-24'}
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