Publication Information

{'id': 'https://openalex.org/W2059044564', 'doi': 'https://doi.org/10.1016/s0022-5347(05)00005-4', 'title': 'Aloe-Emodin Induces Apoptosis in T24 Human Bladder Cancer Cells Through the p53 Dependent Apoptotic Pathway', 'display_name': 'Aloe-Emodin Induces Apoptosis in T24 Human Bladder Cancer Cells Through the p53 Dependent Apoptotic Pathway', 'publication_year': 2005, 'publication_date': '2005-12-22', 'ids': {'openalex': 'https://openalex.org/W2059044564', 'doi': 'https://doi.org/10.1016/s0022-5347(05)00005-4', 'mag': '2059044564', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16406939'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0022-5347(05)00005-4', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5110208078', 'display_name': 'Jaung-Gung Lin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I184693016', 'display_name': 'China Medical University', 'ror': 'https://ror.org/00v408z34', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I184693016']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Jaung-Gung Lin', 'raw_affiliation_strings': ['School of Chinese Medicine, China Medical University, Taiwan, Republic of China'], 'affiliations': [{'raw_affiliation_string': 'School of Chinese Medicine, China Medical University, Taiwan, Republic of China', 'institution_ids': ['https://openalex.org/I184693016']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111528558', 'display_name': 'Guang-Wei Chen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I184693016', 'display_name': 'China Medical University', 'ror': 'https://ror.org/00v408z34', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I184693016']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Guang-Wei Chen', 'raw_affiliation_strings': ['School of Chinese Medicine, China Medical University, Taiwan, Republic of China'], 'affiliations': [{'raw_affiliation_string': 'School of Chinese Medicine, China Medical University, Taiwan, Republic of China', 'institution_ids': ['https://openalex.org/I184693016']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109084781', 'display_name': 'Te-Mao Li', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I184693016', 'display_name': 'China Medical University', 'ror': 'https://ror.org/00v408z34', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I184693016']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Te-Mao Li', 'raw_affiliation_strings': ['School of Chinese Medicine, China Medical University, Taiwan, Republic of China'], 'affiliations': [{'raw_affiliation_string': 'School of Chinese Medicine, China Medical University, Taiwan, Republic of China', 'institution_ids': ['https://openalex.org/I184693016']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074975846', 'display_name': 'Se-Tze Chouh', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I177918364', 'display_name': 'Providence University', 'ror': 'https://ror.org/03fcpsq87', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I177918364']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Se-Tze Chouh', 'raw_affiliation_strings': ['Department of Food and Nutrition, Providence University, Taiwan, Republic of China'], 'affiliations': [{'raw_affiliation_string': 'Department of Food and Nutrition, Providence University, Taiwan, Republic of China', 'institution_ids': ['https://openalex.org/I177918364']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111939314', 'display_name': 'Tzu-Wei Tan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I184693016', 'display_name': 'China Medical University', 'ror': 'https://ror.org/00v408z34', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I184693016']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Tzu-Wei Tan', 'raw_affiliation_strings': ['Department of Pharmacology, China Medical University, Taiwan, Republic of China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, China Medical University, Taiwan, Republic of China', 'institution_ids': ['https://openalex.org/I184693016']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5087091914', 'display_name': 'Jing‐Gung Chung', 'orcid': 'https://orcid.org/0000-0002-7303-2287'}, 'institutions': [{'id': 'https://openalex.org/I184693016', 'display_name': 'China Medical University', 'ror': 'https://ror.org/00v408z34', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I184693016']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Jing-Gung Chung', 'raw_affiliation_strings': ['Department of Microbiology, China Medical University, Taiwan, Republic of China'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, China Medical University, Taiwan, Republic of China', 'institution_ids': ['https://openalex.org/I184693016']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.293, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 102, 'citation_normalized_percentile': {'value': 0.958841, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '175', 'issue': '1', 'first_page': '343', 'last_page': '347'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12346', 'display_name': 'Phytochemistry and biological activity of medicinal plants', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12346', 'display_name': 'Phytochemistry and biological activity of medicinal plants', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12356', 'display_name': 'Bioactive Compounds and Antitumor Agents', 'score': 0.9885, 'subfield': {'id': 'https://openalex.org/subfields/3005', 'display_name': 'Toxicology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13128', 'display_name': 'Chromatography in Natural Products', 'score': 0.9601, 'subfield': {'id': 'https://openalex.org/subfields/1602', 'display_name': 'Analytical Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cyclin-b1', 'display_name': 'Cyclin B1', 'score': 0.66886336}, {'id': 'https://openalex.org/keywords/viability-assay', 'display_name': 'Viability assay', 'score': 0.6562589}], 'concepts': [{'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.80943847}, {'id': 'https://openalex.org/C2778437423', 'wikidata': 'https://www.wikidata.org/wiki/Q5198265', 'display_name': 'Cyclin B1', 'level': 5, 'score': 0.66886336}, {'id': 'https://openalex.org/C53227056', 'wikidata': 'https://www.wikidata.org/wiki/Q189152', 'display_name': 'Viability assay', 'level': 3, 'score': 0.6562589}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.47313848}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.42776388}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.4270175}, {'id': 'https://openalex.org/C105696609', 'wikidata': 'https://www.wikidata.org/wiki/Q1068809', 'display_name': 'Cell cycle checkpoint', 'level': 4, 'score': 0.42415786}, {'id': 'https://openalex.org/C199835354', 'wikidata': 'https://www.wikidata.org/wiki/Q15311861', 'display_name': 'Cyclin D1', 'level': 4, 'score': 0.41444725}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.34552205}, {'id': 'https://openalex.org/C120504264', 'wikidata': 'https://www.wikidata.org/wiki/Q1147372', 'display_name': 'Cyclin-dependent kinase 1', 'level': 4, 'score': 0.2927177}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.29071987}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.09742522}], 'mesh': [{'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D004642', 'descriptor_name': 'Emodin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D001749', 'descriptor_name': 'Urinary Bladder Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D000880', 'descriptor_name': 'Anthraquinones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004642', 'descriptor_name': 'Emodin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001749', 'descriptor_name': 'Urinary Bladder Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0022-5347(05)00005-4', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16406939', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 19, 'referenced_works': ['https://openalex.org/W1571252798', 'https://openalex.org/W1574086514', 'https://openalex.org/W1977707442', 'https://openalex.org/W1991328731', 'https://openalex.org/W2002507218', 'https://openalex.org/W2017975463', 'https://openalex.org/W2058994019', 'https://openalex.org/W2073342325', 'https://openalex.org/W2078297328', 'https://openalex.org/W2084533871', 'https://openalex.org/W2092409818', 'https://openalex.org/W2096536930', 'https://openalex.org/W2111714805', 'https://openalex.org/W2130066394', 'https://openalex.org/W2131840309', 'https://openalex.org/W2154402987', 'https://openalex.org/W2161261662', 'https://openalex.org/W2253959633', 'https://openalex.org/W2317624627'], 'related_works': ['https://openalex.org/W4296270000', 'https://openalex.org/W3107603624', 'https://openalex.org/W3103815445', 'https://openalex.org/W3084440299', 'https://openalex.org/W2919428694', 'https://openalex.org/W2411653697', 'https://openalex.org/W2119108207', 'https://openalex.org/W1995228374', 'https://openalex.org/W1972085353', 'https://openalex.org/W1458434589'], 'abstract_inverted_index': {'No': [0], 'AccessJournal': [1], 'of': [2, 38, 46, 53, 61, 68, 76, 83, 91, 98, 105, 113, 120, 141, 195, 227, 237, 240, 261, 303, 318, 338, 390, 438, 460, 477, 520, 525, 546, 611, 654, 662, 691, 740, 748, 758, 766, 776, 784, 794, 802, 812, 819, 829, 836], 'UrologyInvestigative': [3], 'urology1': [4], 'Jan': [5], '2006Aloe-Emodin': [6], 'Induces': [7], 'Apoptosis': [8], 'in': [9, 144, 220, 280, 295, 366, 395, 414, 419, 434, 441, 484, 505, 548, 575, 617, 631, 658, 677], 'T24': [10, 146, 221, 296, 509, 579], 'Human': [11], 'Bladder': [12], 'Cancer': [13, 327, 620, 667], 'Cells': [14], 'Through': [15], 'the': [16, 138, 145, 225, 238, 259, 301, 367, 478, 612, 683], 'p53': [17, 253, 590], 'Dependent': [18], 'Apoptotic': [19], 'Pathway': [20], 'Jaung-Gung': [21, 34, 737], 'Lin,': [22], 'Guang-Wei': [23, 49, 755], 'Chen,': [24], 'Te-Mao': [25, 64, 773], 'Li,': [26], 'Se-Tze': [27, 79, 791], 'Chouh,': [28], 'Tzu-Wei': [29, 94, 809], 'Tan,': [30], 'and': [31, 85, 108, 155, 165, 186, 200, 214, 218, 229, 231, 244, 255, 263, 283, 308, 336, 353, 372, 388, 416, 462, 467, 482, 503, 522, 688, 796], 'Jing-Gung': [32, 109, 826], 'Chung': [33, 111, 827], 'LinJaung-Gung': [35], 'Lin': [36, 738], 'School': [37, 52, 67, 739, 757, 775], 'Chinese': [39, 54, 69, 741, 759, 777], 'Medicine,': [40, 55, 70, 742, 760, 778], 'China': [41, 47, 56, 62, 71, 77, 92, 100, 106, 115, 121, 743, 749, 761, 767, 779, 785, 803, 814, 820, 831, 837], 'Medical': [42, 57, 72, 101, 116, 744, 762, 780, 815, 832], 'University,': [43, 58, 73, 88, 102, 117, 745, 763, 781, 799, 816, 833], 'Taiwan,': [44, 59, 74, 89, 103, 118, 746, 764, 782, 800, 817, 834], 'Republic': [45, 60, 75, 90, 104, 119, 747, 765, 783, 801, 818, 835], ',': [48, 63, 78, 93, 107], 'ChenGuang-Wei': [50], 'Chen': [51, 756], 'LiTe-Mao': [65], 'Li': [66, 774], 'ChouhSe-Tze': [80], 'Chouh': [81, 792], 'Department': [82, 97, 112, 793, 811, 828], 'Food': [84, 447, 537, 581, 795], 'Nutrition,': [86, 797], 'Providence': [87, 798], 'TanTzu-Wei': [95], 'Tan': [96, 810], 'Pharmacology,': [99, 813], 'ChungJing-Gung': [110], 'Microbiology,': [114, 830], 'View': [122], 'All': [123, 852], 'Author': [124, 735], 'Informationhttps://doi.org/10.1016/S0022-5347(05)00005-4AboutFull': [125], 'TextPDF': [126], 'ToolsAdd': [127], 'to': [128, 178, 235], 'favoritesDownload': [129], 'CitationsTrack': [130], 'CitationsPermissionsReprints': [131], 'ShareFacebookLinked': [132], 'InTwitterEmail': [133], 'Abstract': [134], 'Purpose:': [135], 'We': [136], 'investigated': [137], 'anticancer': [139, 319], 'effect': [140], 'AE': [142, 210, 223, 251, 273, 292], '(1,8-dihydroy-3-[hydroxymethyl]-anthraquione)': [143], 'human': [147, 396, 442, 506, 549, 576], 'bladder': [148, 507, 577], 'cancer': [149, 508, 578, 665], 'cell': [150, 184, 212, 351, 354, 364, 393, 399, 439], 'line': [151], '(Food': [152], 'Industry': [153], 'Research': [154], 'Development': [156], 'Institute,': [157], 'Hsinchu,': [158], 'Taiwan)': [159], 'by': [160, 190, 205, 258, 533, 554, 638, 682, 716, 730, 752, 770, 788, 806, 823, 848], 'studying': [161], 'apoptosis': [162, 187, 219, 294, 418, 504, 547, 571, 636, 676], 'regulation.': [163], 'Materials': [164], 'Methods:': [166], 'AE,': [167], 'which': [168, 247, 266], 'is': [169, 298, 314, 370, 680], 'purified': [170], 'from': [171, 529, 635], 'aloe': [172], 'vera': [173], 'leaves,': [174], 'has': [175], 'been': [176], 'reported': [177], 'have': [179, 233], 'antitumor': [180], 'activity.': [181], 'Cell': [182, 708], 'viability,': [183, 213], 'cycle': [185, 440, 629], 'were': [188, 203], 'determined': [189], 'flow': [191], 'cytometric': [192], 'methods.': [193, 208], 'Levels': [194], 'cyclins,': [196], 'cyclin-dependent': [197, 241, 613], 'kinase': [198, 242, 411, 614], '1': [199, 243, 311], 'other': [201, 841], 'enzyme': [202], 'examined': [204], 'Western': [206], 'blotting': [207], 'Results:': [209], 'inhibited': [211, 288], 'induced': [215, 252, 293, 433, 498, 570, 637], 'G2/M': [216, 249, 436], 'arrest': [217, 437, 502, 630], 'cells.': [222, 446, 510, 580], 'increased': [224], 'levels': [226, 239], 'Wee1': [228], 'cdc25c,': [230], 'may': [232], 'led': [234], 'inhibition': [236], 'cyclin': [245, 596], 'B1,': [246], 'cause': [248], 'arrest.': [250], 'expression': [254, 285], 'was': [256, 267, 274], 'accompanied': [257], 'induction': [260], 'p21': [262, 616], 'caspase-3': [264, 573], 'activation,': [265, 465], 'associated': [268, 275], 'with': [269, 276, 321, 374, 843], 'apoptosis.': [270, 618], 'In': [271, 559, 844], 'addition,': [272], 'a': [277, 315, 375, 592, 659], 'marked': [278], 'increase': [279], 'Fas/APO1': [281], 'receptor': [282, 378, 458, 481], 'Bax': [284, 307], 'but': [286], 'it': [287], 'Bcl-2': [289, 704], 'expression.': [290], 'Conclusions:': [291], 'cells': [297, 553, 634, 679], 'mediated': [299, 681], 'through': [300, 595], 'activation': [302, 690], 'p53,': [304], 'p21,': [305], 'Fas/APO-1,': [306], 'caspase-3.': [309], 'References': [310], ':': [312, 334, 347, 362, 386, 409, 431, 455, 475, 495, 518, 544, 566, 589, 608, 627, 651, 674, 702], 'Aloe-emodin': [313, 432], 'new': [316], 'type': [317], 'agent': [320], 'selective': [322], 'activity': [323, 574], 'against': [324], 'neuroectodermal': [325], 'tumors.': [326], 'Res2000;': [328, 709], '60:': [329], '2800.': [330], 'Google': [331, 344, 359, 383, 406, 428, 452, 472, 492, 515, 541, 563, 586, 605, 624, 648, 671, 699, 712], 'Scholar': [332, 345, 360, 384, 407, 429, 453, 473, 493, 516, 542, 564, 587, 606, 625, 649, 672, 700, 713], '2': [333], 'Mechanisms': [335], 'genes': [337], 'cellular': [339, 461], 'suicide.': [340], 'Science1995;': [341], '267:': [342], '1445.': [343], '3': [346], 'Social': [348], 'controls': [349], 'on': [350, 392], 'survival': [352], 'death.': [355, 468], 'Nature1992;': [356], '356:': [357], '397.': [358], '4': [361], 'Programmed': [363], 'death': [365, 394], 'Drosophila': [368], 'CNS': [369], 'ecdysone-regulated': [371], 'coupled': [373], 'specific': [376], 'ecdysone': [377], 'isoform.': [379], 'Development1993;': [380], '119:': [381], '1251.': [382, 451], '5': [385], 'Effects': [387], 'mechanisms': [389], 'aloe-emodin': [391], 'lung': [397, 420], 'squamous': [398], 'carcinoma.': [400], 'Eur': [401], 'J': [402, 424, 487, 536, 694], 'Pharmacol2001;': [403, 425], '431:': [404], '287.': [405], '6': [408], 'Protein': [410], 'C': [412], 'involvement': [413], 'aloe-emodin-': [415], 'emodin-induced': [417], 'carcinoma': [421], 'cell.': [422], 'Br': [423], '134:': [426], '1093.': [427], '7': [430], 'vitro': [435], 'promyelocytic': [443, 550], 'leukemia': [444, 551], 'HL-60': [445, 552], 'Chem': [448, 582], 'Toxicol2004;': [449, 583], '42:': [450, 584], '8': [454], 'The': [456, 609, 703], 'TNF': [457], 'superfamily': [459], 'viral': [463], 'proteins:': [464], 'costimulation,': [466], 'Cell1994;': [469], '76:': [470], '959.': [471], '9': [474], 'Involvement': [476], 'CD95': [479, 684], '(APO-1/Fas)': [480, 685], 'ligand': [483], 'liver': [485], 'damage.': [486], 'Exp': [488, 707], 'Med1995;': [489], '182:': [490], '1223.': [491], '10': [494], 'Ellagic': [496], 'acid': [497], 'p53/p21': [499], 'expression,': [500], 'G1': [501, 632], 'Anticancer': [511], 'Res2005;': [512], '25:': [513], '971.': [514], '11': [517], 'Evaluation': [519], 'antioxidative': [521], 'mutagenic': [523], 'properties': [524], '50%': [526], 'ethanolic': [527], 'extract': [528], 'red': [530], 'beans': [531], 'fermented': [532], 'Aspergillus': [534], 'oryzae.': [535], 'Prot2002;': [538], '65:': [539], '1463.': [540], '12': [543], 'Induction': [545], 'Ampelopsis': [555], 'cantoniensis': [556], 'crude': [557], 'extract.': [558], 'Vivo2004;': [560], '18:': [561], '457.': [562], '13': [565], 'Diallyl': [567], 'disulfide': [568], '(DADS)': [569], 'undergo': [572], '1543.': [585], '14': [588], 'Regulates': [591], 'G2': [593], 'checkpoint': [594], 'B1.': [597], 'Proc': [598], 'Natl': [599], 'Acad': [600], 'Sci': [601], 'USA1999;': [602], '96:': [603], '2147.': [604], '15': [607], 'role': [610], 'inhibitor': [615], 'Mol': [619], 'Ther2002;': [621], '1:': [622], '639.': [623], '16': [626], 'p21-induced': [628], 'protects': [633], 'UV-irradiation': [639], 'or': [640], 'RNA': [641], 'polymerase': [642], 'II': [643], 'blockage.': [644], 'Oncogene1998;': [645], '16:': [646], '3461.': [647], '17': [650], 'Prognostic': [652], 'value': [653], 'P53': [655], 'gene': [656], 'mutations': [657], 'large': [660], 'series': [661], 'node-negative': [663], 'breast': [664], 'patients.': [666], 'Res1998;': [668], '58:': [669], '1451.': [670], '18': [673], 'Drug-induced': [675], 'hepatoma': [678], 'receptor/ligand': [686], 'system': [687], 'involves': [689], 'wild-type': [692], 'p53.': [693], 'Clin': [695], 'Invest1997;': [696], '99:': [697], '403.': [698], '19': [701], 'protein': [705], 'family.': [706], '256:': [710], '50.': [711], '©': [714], '2006': [715, 729], 'American': [717, 731], 'Urological': [718, 732], 'AssociationFiguresReferencesRelatedDetails': [719], 'Volume': [720], '175Issue': [721], '1January': [722], '2006Page:': [723], '343-347': [724], 'Advertisement': [725, 853], 'Copyright': [726], '&': [727], 'Permissions©': [728], 'AssociationKeywordsemodinapoptosisbladderbladder': [733], 'neoplasmsaloeMetrics': [734], 'Information': [736], 'More': [750, 768, 786, 804, 821, 846], 'articles': [751, 769, 787, 805, 822, 847], 'this': [753, 771, 789, 807, 824, 849], 'author': [754, 772, 790, 808, 825, 850], 'Financial': [838], 'interest': [839], 'and/or': [840], 'relationship': [842], 'Vivo.': [845], 'Expand': [851], 'PDF': [854], 'downloadLoading': [855], '...': [856]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2059044564', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2025-01-06T08:45:57.477296', 'created_date': '2016-06-24'}