Focus on oxidative stress in the cardiovascular and renal systems

Name: Work Video:
Duration: 3 min 30 s
Christopher S. Wilcox; David D. Gutterman
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[130], '26,': [131], '30,': [132, 4339], '36,': [133], '37,': [134, 3730], '43–46).Oxidative': [135], 'remains': [137], 'elusive': [139], 'phenomenon.': [140], 'It': [141, 147], 'is': [142, 214, 250, 336, 352, 425, 464, 502, 528, 541, 755, 761, 849, 896, 908, 945, 972, 1126, 1430, 1489, 1733, 3110, 3272, 4396], 'difficult': [143, 414], 'even': [144], 'define.': [146], 'represents': [148], 'excess': [150], 'reactive': [152, 320, 733, 1819, 2182, 3002], 'oxygen': [153, 1353, 1358, 1820, 3003, 3030, 3099, 3397, 3672], 'species': [154, 321, 734, 1821, 2183, 3004, 3673], '(ROS)': [155], 'tissues': [158, 586, 3709], 'under': [159, 542, 587, 641], 'consideration': [160], 'or': [161, 189, 281, 283, 385, 444, 480, 482, 514, 727, 920, 1504, 1558, 1581, 1766, 3449], 'whole': [164, 349], 'body.': [165], 'This': [166, 721, 1125], 'implies': [167], 'either': [168], 'increased': [170, 1101, 1110, 1262], 'production': [171, 836, 1926, 2351, 4075], 'ROS,': [173], 'for': [174, 207, 534, 621, 762, 1412, 1600, 3789], 'example,': [175, 535, 622, 1601], 'by': [176, 272, 287, 312, 378, 417, 427, 530, 638, 974, 1109, 1219, 1289, 1432, 1654, 1696, 1708, 1798, 1818, 2441, 3075, 3555, 4037, 4276, 4398, 4434, 4602], 'specific': [177, 531, 816], 'oxidase': [178, 640, 913, 949, 961, 993, 1013, 1205, 1268, 1854, 1897, 2396, 4079], 'such': [179, 231, 247, 260, 322, 371, 474, 735, 1514, 1611], 'as': [180, 216, 232, 261, 323, 475, 553, 555, 592, 604, 736, 766, 877, 879, 1515, 1612, 3183, 4489], 'NADPH': [181, 639, 912, 992, 1012, 1204, 1267, 1853, 1896, 2146, 2395], 'oxidase,': [182, 184], 'xanthine/xanthine': [183], 'various': [185], 'arachidonic': [186], 'acid': [187, 285], 'monooxygenases,': [188], 'mitochondrial': [191, 221], 'respiratory': [192], 'chain.': [193], 'Alternatively,': [194], 'it': [195, 2197], 'may': [196, 521, 551, 873, 1370, 2147], 'derive': [197], 'from': [198, 266, 402, 677, 1507, 1712, 3234, 4279, 4386, 4588], 'a': [199, 248, 515, 605, 708, 756, 1024, 1070, 1099, 1150, 1372, 1385, 1448, 1574, 1589, 1635, 1676, 1752, 1771, 1802, 2600, 3184, 3588, 3906, 4196, 4490, 4565], 'failure': [200], 'metabolize': [202, 224, 240], 'ROS.': [203, 1220], 'The': [204, 798, 825, 1270, 1649, 2230, 3737], 'major': [205], 'pathways': [206, 1499, 1513], 'metabolism': [208], 'are': [209, 290, 326, 374, 413, 456, 494, 833, 1041, 1123, 1284, 1336, 1417, 1494, 1509, 1529, 3073], 'superoxide': [210, 225, 2154, 2398, 2728, 4074], 'dismutase': [211], '(SOD),': [212], 'which': [213, 373, 429, 971, 1398, 1528], 'expressed': [215], 'extracellular': [217, 2770], '(EC),': [218], 'intracellular,': [219], 'isoforms': [222], 'anion': [226, 263], '(O2−·)': [227], 'H2O2.': [229], 'Peroxidases': [230], 'catalase': [233], 'glutathione': [235, 540, 546], 'peroxidase': [236, 547], '(predominantly': [237], 'intracellular)': [238], 'further': [239, 729, 1045, 1373], 'H2O2': [241, 719, 754, 763, 773, 801, 838, 848, 861, 2597, 2636], 'O2': [243, 1344, 1410], 'water.': [245], 'However,': [246, 518], 'definition': [249], 'highly': [251, 319, 732], 'simplistic': [252], 'because': [253, 1428], 'other,': [256], 'biologically': [257, 471], 'important,': [258], 'ROS': [259, 302, 363, 591, 1039, 1046, 1067, 1148, 1239, 1276, 1335, 1493, 1508, 1520], 'hydroxyl': [262], '(·OH)': [264], 'formed': [265, 270, 286, 375], 'H2O2,': [267, 452, 1107], 'peroxynitrate': [268], '(ONOO−)': [269], 'principally': [271], 'interaction': [274, 380, 601, 814, 1816], 'nitric': [276, 2009, 2045, 2275, 2349, 2731, 2794, 2822, 2972, 3376, 4559], 'oxide': [277, 2010, 2350, 2523, 2732, 2795, 2823, 2973, 3377, 4560], '(NO)': [278], 'O2−': [280], '·OH,': [282], 'hypochlorous': [284], 'myeloperoxidase.': [288], 'There': [289], 'multiple': [291, 1497, 2106], 'other': [292, 296, 921, 1074], 'reaction': [293, 411, 423], 'products': [294, 361, 370, 391, 412, 473], 'with': [295, 383, 602, 815, 1261, 1343, 1560, 1630, 3237, 3598, 3691, 3835, 3977, 4131, 4149, 4194], 'mediators.': [297], 'Important': [298], 'interactions': [299], 'occur': [300, 841], 'between': [301, 1741, 1762], 'NO': [304, 310, 455, 603, 649, 669, 704, 895, 1131, 1274, 1342, 1925, 3553], 'where': [305, 524, 753], 'O2−·': [306, 382, 598, 636, 667, 696, 930, 1427], 'reduces': [309, 1018, 4169], 'bioactivity': [311], 'shortening': [313], 'its': [314, 600, 806, 813], 'half-life': [315], 'generates': [318, 430], 'ONOO−': [324, 397], 'themselves': [327, 1040], 'implicated': [328, 1500], 'nitrosating': [332], 'reactions.No': [333], 'less': [334], 'problematic': [335], 'quantitative': [338], 'assessment': [339, 566], '(10).': [343], 'At': [344, 437], 'level': [346, 439, 1348], 'animal,': [350], 'use': [351, 1409], 'often': [353], 'made': [354, 1797], 'appearance': [357], 'oxidized': [359], 'end': [360], 'metabolism.': [364], 'These': [365, 1096, 1338], 'end-products': [366], 'include': [367, 392, 1339, 1760], 'lipid': [368, 3650], 'peroxidation': [369], 'isoprostanes,': [372], 'predominantly': [376], 'nonenzymically': [377], 'arachidonate': [384], 'malondialdehyde.': [386], 'More': [387, 4587], 'stable': [388], 'long-lasting': [390], 'modifications': [394], 'DNA.': [396], 'can': [398, 722, 1158, 1604], 'be': [399, 552, 723, 728, 777, 874, 1548], 'assessed': [400, 671], 'semiquantitatively': [401], 'nitrosation': [403], 'tyrosine': [405, 435], 'epitopes': [406], 'proteins,': [408], 'quantify': [416], 'Western': [418], 'blot': [419], 'analysis.': [420], 'Moreover,': [421, 1166], 'influenced': [426], 'nitrase,': [428], 'NO2−': [431], 'reverses': [433], 'nitration.': [436], 'isolated': [442], 'vessels': [443, 752, 1190], 'single': [445], 'cells,': [446, 791, 805], 'fluorescent': [447], 'probes': [448], 'detect': [450], 'O2−·,': [451], 'ONOO−,': [453], 'receiving': [457], 'attention.': [459], 'particularly': [461, 596], 'promising': [462], 'technique': [463, 505, 3590], 'assess': [466], 'redox': [468, 496, 509, 557, 569, 580, 3105], 'ratio': [469, 538], 'determined': [472, 529], 'oxidized:reduced': [476, 483, 537], 'thiols': [477, 493], '(e.g.,': [478, 485], 'cysteine': [479], 'homocysteine)': [481], 'nucleotides': [484], 'flavin': [486], 'adenine': [487], 'dinucleotide)': [488], 'within': [489, 582, 1327, 1553, 4452], 'cells.': [490, 2311, 3166], 'Because': [491], 'equilibrium': [497], 'throughout': [498], 'body,': [500], 'attractive': [504], 'sample': [507], 'chemistry': [510], 'body': [513], 'particular': [516], 'tissue.': [517], 'approach': [520], 'break': [522], 'down': [523], 'thiol-redox': [526], 'pair': [527, 563], 'enzyme': [532], 'regulations,': [533], 'control': [544], 'reductase': [549], 'state': [558, 581], 'governing': [560], 'thiol': [562], 'ratio.': [564], 'Nevertheless,': [565], 'appropriate': [568], 'pairs': [570], 'gets': [571], 'more': [572], 'directly': [573, 672], 'problem': [576], 'quantitating': [578], 'cells': [584, 781, 822], 'study.Initial': [588], 'interest': [589, 713, 1488], 'vasoactive': [593, 757], 'mediators': [594], 'focused': [595, 1631], 'mechanism': [606, 4492], 'explain': [608], 'endothelial': [609, 780, 804, 835, 1130, 3187, 3223, 4083, 4272], 'dysfunction': [610, 1503, 1608, 1964, 2038, 2268, 3224, 4237], '(12,': [611], '16,': [612], '31)': [613], 'vasoconstriction': [616], '(2,': [617], '3,': [618], '31,': [619, 3957], '42),': [620], 'ANG': [624, 645, 691, 710, 917, 1008, 1064, 1180, 1406, 1842], 'II-induced': [625, 3270], 'hypertension': [626, 1257, 1301, 2439, 3986, 4176], '(1,': [627], '27).': [628], 'Mori': [629, 1915, 2719], 'Cowley': [631, 1912, 2630, 2722], '(24)': [632], 'had': [633, 1770], 'shown': [634], 'generated': [637, 778, 973, 3911], 'influence': [643], 'II': [646, 692, 711, 918, 1009, 1065, 1181, 1843, 3161, 3230, 3550, 3716, 4451], 'modifies': [647, 2729], 'tubulovascular': [648, 2730], 'cross-talk': [650, 2733], 'outer': [653, 2736], 'medulla.': [654, 681, 2737], 'In': [655, 738, 980, 1221, 1439], 'issue,': [657, 740, 1078, 1223, 1441], 'Pallone': [658, 2815, 3546], 'colleagues': [660], '(48)': [661], 'report': [662, 745, 988, 1088, 1228, 1395, 1446], 'their': [663, 746, 855, 989, 1089, 1167, 1229, 1396], 'study': [664, 1230, 1288, 1333, 1751], 'microvascular': [666, 2267, 3585], 'generation': [670, 697, 705, 931, 1047, 1240, 1425, 2155, 2598, 3554], 'vasa': [674, 699, 3558], 'recta': [675, 700], 'dissected': [676], 'rat': [679, 1001, 1903, 3556], 'They': [682, 857, 1004, 1036, 1145, 1419, 1465], 'show': [683, 1178, 1302], 'that,': [684], 'unlike': [685], 'afferent': [687, 3232, 3425], 'arterioles': [688, 3233], '(38),': [689], 'chronic': [690, 1536, 2704, 2941], 'does': [693, 839], 'stimulate': [695], 'indeed': [702, 840], 'enhances': [703, 2757], 'leading': [706, 1137, 1472, 2039], 'diminished': [709, 796], 'constriction.Increasing': [712], 'focuses': [714], '(19–22).': [720], 'active': [724, 3760], 'itself': [725], '(20)': [726], 'metabolized': [730], '·OH.': [737], 'Hatoum': [741, 829, 2217, 2257], 'et': [742, 830, 925, 985, 1080, 1085, 1197, 1225, 1291, 1392, 1443], 'al.': [743, 831, 926, 986, 1081, 1086, 1198, 1226, 1292, 1393, 1444], '(11)': [744, 832], 'studies': [747, 990, 1090, 1168, 1246, 1295, 1397], 'human': [749, 2072, 2239, 2566, 2607, 2670, 2879, 2931, 3006], 'submucosal': [750, 2240], 'intestinal': [751, 2241], 'mediator.': [758], 'One': [759], 'pathway': [760, 2104], 'act': [765], 'endogenous': [768], 'endothelium-derived': [769, 880], 'hyperpolarizing': [770], 'factor': [771, 1369], '(EDHF).': [772], 'was': [774, 1651], 'considered': [775], 'activate': [784], 'potassium': [785, 1479, 3081], 'channels': [786, 817, 1480], 'vascular': [788, 819, 1102, 1161, 1170, 2308, 2435, 3101, 3130, 3163, 3279, 3476, 3676, 4236], 'smooth': [789, 820, 1171, 1207, 2309, 2488, 2531, 2563, 3164, 3280], 'muscle': [790, 821, 1172, 1208, 2310, 2489, 2564, 3165], 'thereby': [792, 1057], 'causing': [793], 'hyperpolarization': [794], 'reactivity.': [797], 'source': [799], 'transmembrane': [807], 'passage,': [808], 'details': [811], 'unclear.': [824], 'new': [826, 1330, 1386, 1592, 1739], 'findings': [827, 1212], 'response': [843, 1186, 2936, 4205, 4347, 4383], 'acetylcholine': [845], 'simply': [851], 'EDHF': [853, 872], 'vessels.': [856], 'provide': [858], 'evidence': [859, 869], 'functions': [862], 'rather': [863, 963], 'release': [865, 2527], 'EDHF.': [867], 'Increasing': [868], 'suggests': [870, 1591], 'least': [876], 'relaxing': [881, 2108], 'factor-NO': [882], 'tone': [887], 'contractility': [889], 'resistance': [892, 2609], 'vessels,': [893, 1557], 'whereas': [894], 'generally': [897], 'predominant': [899], 'importance': [900, 907], 'large': [903], 'conduit': [904], 'vessels.Of': [905], 'special': [906, 982], 'activity': [914, 1014, 2561], 'during': [915, 938, 1069, 1801, 4206], 'prolonged': [916, 1007, 1457], 'exposure': [919, 2004, 4281], 'stimuli.': [923], 'Gupte': [924, 2085, 2128, 3468], '(9)': [927], 'compare': [928], 'NADPH-dependent': [929], 'bovine': [933, 2111, 2157, 2760], 'pulmonary': [934, 2160, 4081], 'coronary': [936, 2112, 2158, 2529, 2567, 2608, 2671, 2761, 3007], 'arteries': [937, 2762], 'hypoxia.': [941], 'An': [942, 4254], 'finding': [944], 'differences': [947, 1280, 1323, 2149, 2344], 'activities': [950], 'relate': [951, 1319, 1420, 1466], 'expression': [955, 998, 1103, 1264, 1326, 1383, 1469, 2393, 4444], 'components': [958], 'NADAH': [960], 'availability': [966], 'substrate': [969], 'NADPH,': [970], 'glucose': [975], '6-phosphate': [976], 'dehydrogenase': [977], '(8,': [978], '25).': [979], 'section,': [983], 'Welch': [984, 1391, 1835, 1885, 2382, 3296, 3329, 3363, 3444, 3541], '(41)': [987, 1394], 'activity,': [994, 4174], 'p22phox,': [995], 'EC-SOD': [997, 1135], 'cortex.': [1003], 'confirm': [1005, 1399], 'infusion': [1010, 1022, 3551], 'increases': [1011, 3552, 4073], 'p22phox': [1016, 1053, 1105, 1193, 1202, 2492, 3277], 'EC-SOD.': [1019], 'Remarkably,': [1020], 'concurrent': [1021], 'permeant': [1025], 'SOD': [1026, 1156, 1436], 'mimetic': [1027, 1437], 'obviate': [1029], 'prevents': [1032], 'all': [1033], 'changes.': [1035], 'conclude': [1037, 1146, 1200], 'autocatalytic': [1042], 'induce': [1044], 'via': [1051, 2763], 'increase': [1052, 1152], 'reduced': [1055], 'EC-SOD,': [1056], 'contributing': [1058], 'sustained': [1061], 'effects': [1062, 3067, 3702, 3756, 3799, 4231], 'accumulation': [1068], 'slow': [1071], 'pressor': [1072], 'response.In': [1073], 'Weber': [1079, 1196, 2463, 3254], '(39)': [1082, 1199], 'Laude': [1084, 2455, 3260], '(17)': [1087], 'transgenic': [1092], 'mice': [1093, 1097, 3275], 'overexpressing': [1094, 1194, 3276], 'p22phox.': [1095], 'have': [1098, 1748], 'twofold': [1100], 'accompanied': [1108], 'NOX-1': [1111], '(13).': [1112], 'Yet,': [1113], 'despite': [1114], 'this,': [1115], 'pressure': [1118, 3402], 'endothelium-dependent': [1120], 'relaxation': [1121], 'responses': [1122, 3227], 'intact.': [1124], 'related': [1127], 'enhanced': [1129, 1140, 1308, 3226], 'synthase': [1132, 2011, 2974], '(eNOS)': [1133], 'expression,': [1136], 'capacity': [1141], 'generate': [1143], 'NO.': [1144], 'evoke': [1149], 'compensatory': [1151], 'eNOS': [1154], 'maintain': [1159], 'function': [1162, 3586], 'hemodynamics': [1164], '(17).': [1165], 'cell': [1173, 1209, 2037, 2191, 3802, 4273], 'hypertrophy': [1174, 3271], 'model': [1177, 1260, 1299, 4181], 'causes': [1182], 'exaggerated': [1184], 'structural': [1185], 'mice.': [1195, 2494], 'potentiate': [1206], 'hypertrophy.': [1210], 'Their': [1211, 1245, 1294], 'raise': [1213], 'questions': [1215], 'concerning': [1216], 'signaling': [1218, 1498, 3106, 3378], 'Yang': [1224, 3491], '(47)': [1227], 'phospholipase': [1235, 3515], 'D': [1236], '(PLD)': [1237], 'mouse': [1243, 1254, 3833], 'kidney.': [1244, 1904], 'dopamine': [1249, 3511], '5': [1250], '(D5)': [1251], 'receptor': [1252, 3369, 3512, 4199], 'knockout': [1253], 'associate': [1255], 'PLD': [1263], 'engages': [1266, 1569], 'activity.': [1269], 'potential': [1271], 'relevance': [1272], 'explaining': [1278], 'gender': [1279], 'injury': [1283, 2347, 4180, 4343], 'explored': [1285], 'Ji': [1290, 2326], '(14).': [1293], 'renal-wrap': [1298], 'similar': [1303], 'degrees': [1304], 'hypertension,': [1306], 'yet': [1307], 'indexes': [1309], 'damage': [1312, 1552, 2186, 3131, 3893, 4432], 'male': [1314, 4457], 'rats': [1315, 1408, 4130], 'authors': [1318], 'gender-specific': [1321], 'regional': [1322], 'NOS': [1325], 'kidneys.Many': [1329], 'avenues': [1331], 'emerging.': [1337], 'competition': [1340], 'setting': [1346], 'cellular': [1350, 1522, 1892], 'respiration': [1351], 'usage': [1354], 'hence': [1356], 'tension': [1359], 'tissues.': [1362], 'Consequent': [1363], 'activation': [1364, 1475, 1510, 2767, 3076, 4488], 'hypoxia': [1367, 1422, 1429, 1453], 'inducible': [1368, 2926], 'engage': [1371], 'set': [1374], 'translational': [1376], 'events': [1377, 1531], 'could': [1379, 1547], 'dictate': [1380], 'altered': [1381], 'gene': [1382], 'pathophysiological': [1389, 1562, 1815, 3027, 3157], 'environment.': [1390], '(40)': [1400], 'chronically': [1405, 1999, 2876], 'II-infused': [1407], 'inefficiently': [1411], 'Na+': [1413], 'reabsorption': [1414], 'consequently': [1416], 'hypoxic.': [1418], 'reversed': [1431], 'confusion': [1433], '(41).': [1438], 'Fitzpatrick': [1442, 1980, 2910], '(5)': [1445], 'period': [1449], 'after': [1454, 3711], 'birth': [1455], 'confers': [1456], 'protection': [1458], 'against': [1459, 3909, 4234], 'cardiac': [1460], 'ischemia': [1461], 'rabbit.': [1464], 'eNOS,': [1471], 'NO-dependent': [1474], 'adenosine': [1477], 'triphosphate': [1478], '(28,': [1481], '29,': [1482], '33).Finally,': [1483], 'area': [1485], 'great': [1487], 'hypothesis': [1491], 'proximate': [1495], 'organ': [1502, 1586, 4431], 'damage.': [1505, 1587], 'Downstream': [1506], 'proinflammatory': [1512], 'nuclear': [1516, 4446], 'factor-κB': [1517], 'link': [1519, 4567], 'adhesion,': [1523], 'inflammation,': [1524], 'cytokine': [1526], 'production,': [1527], 'key': [1530, 2601], 'pathophysiology': [1534], 'diseases': [1540], '(Fig.': [1541, 1615], '1).': [1542], 'hierarchy': [1544], 'envisaged': [1549], 'whereby': [1550, 1594], 'initial': [1551], 'heart,': [1555], 'kidneys,': [1559, 1603], 'secondary': [1561, 1607], 'neurohormones,': [1565], 'pressures,': [1566], 'flows': [1568], 'recruits': [1573], 'wide': [1575], 'range': [1576], 'aggressive': [1578], 'genes,': [1579], 'cytokines,': [1580], 'hormones': [1582], 'perpetuate': [1584], 'Such': [1588], 'schema': [1590], 'mechanisms': [1593, 2109, 3152], 'primary': [1595], 'disease': [1596], 'one': [1598], 'system,': [1599], 'lead': [1605], 'another,': [1610], '1).The': [1616], 'Island': [1623, 1807], 'covered': [1624], 'evolving': [1628], 'issues': [1629], 'presentations': [1632, 1795], 'form': [1634], 'special,': [1636], 'fully': [1637], 'refereed': [1638], 'addition': [1639], 'American': [1642, 3854, 4020, 4064, 4112, 4159, 4186, 4220, 4302, 4420, 4479, 4507, 4545, 4575, 4604], 'Journal': [1643, 3855, 3935, 4021, 4065, 4113, 4134, 4160, 4221, 4303, 4375, 4421, 4480, 4508, 4546, 4576], 'Physiology-Heart': [1645], '&': [1646, 3773, 3792, 4438, 4598], 'Circulatory': [1647], 'Physiology.': [1648], 'meeting': [1650, 1804], 'jointly': [1652], 'sponsored': [1653], 'National': [1656, 1723], 'Heart,': [1657, 1724], 'Lung,': [1658, 1725], 'Blood': [1660, 1727], 'Institute': [1661], 'Program': [1662], 'Project': [1663], 'Grants': [1664], '(PPGs)': [1665], 'PO1-HL-68686': [1666], '(Georgetown': [1667], 'University)': [1668], 'P50-HL-68769': [1670], '(Medical': [1671, 1688], 'College': [1672, 1689], 'Wisconsin),': [1674], 'Specialized': [1677], 'Center': [1678], 'Research': [1680], 'Myocardial': [1682], 'Ischemia': [1683], 'African-Americans': [1685], 'Grant': [1686], 'P50-HL-065203': [1687], 'Wisconsin).': [1691], 'Additional': [1692], 'funds': [1693], 'provided': [1695], 'George': [1698], 'E.': [1699, 4293, 4411], 'Schreiner': [1700], 'Chair': [1701], 'Nephrology': [1703], 'Georgetown': [1705], 'University': [1706], 'unrestricted': [1709], 'educational': [1710], 'grants': [1711, 1732, 1768], 'AstraZeneca,': [1713], 'Boehringer': [1714], 'Ingelheim': [1715], 'Pharmaceutical,': [1716], 'Merck,': [1717], 'GlaxoSmithKlien.The': [1719], 'principle': [1720], 'Institute-sponsored': [1728], 'PPGs': [1729], 'SCOR': [1731, 1767], 'foster': [1735], 'collaboration': [1736, 1761], 'share': [1738], 'ideas': [1740], 'investigators': [1742, 1779], 'working': [1743], 'different': [1745], 'disciplines': [1746], 'who': [1747], 'committed': [1749], 'central': [1753, 3712], 'theme.': [1754], 'We': [1755], 'expanded': [1756], 'vision': [1758], 'three': [1763], 'competing': [1764], 'PPG': [1765], 'focus': [1772], 'stress.': [1775, 3348], 'Participants': [1776], 'included': [1777], 'both': [1778], 'member': [1781], 'external': [1784], 'advisory': [1785], 'committees': [1786], 'projects.': [1789], 'Invited': [1790], 'informal': [1792], '"hot': [1793], 'topic"': [1794], 'group': [1800], '3-day': [1803], 'Plantation,': [1808], 'Florida.': [1809], 'Fig.': [1810], '1.Flow': [1811], 'diagram': [1812], 'some': [1814], 'coordinated': [1817], '(ROS).Download': [1822], 'figureDownload': [1823], 'PowerPointREFERENCES1': [1824], 'Chabrashvili': [1825, 1873, 2372, 3207, 3335], 'T,': [1826, 1874, 1884, 1916, 2373, 2470, 2661, 3208, 3336], 'Kitiyakara': [1827, 1879, 2370], 'C,': [1828, 1880, 2329, 2371], 'Blau': [1829, 2376, 3331], 'J,': [1830, 1957, 1987, 2032, 2141, 2333, 2377, 2423, 2867, 3056, 3214, 3332, 3538], 'Karber': [1831, 2378], 'A,': [1832, 1876, 2098, 2379, 2624, 2992, 3263], 'Aslam': [1833, 2380, 2695, 3209], 'S,': [1834, 2090, 2337, 2381, 2419, 2472, 2474, 2965, 3210], 'WJ,': [1836, 1886, 2383, 3297, 3330, 3542], 'Wilcox': [1838, 1888, 2385, 2692, 3216, 3303, 3338, 3366, 3394, 3419, 3441, 3543], 'CS.': [1839, 1889, 2386, 3217, 3304, 3339, 3367, 3395, 3420], 'Effects': [1840, 3962], 'type': [1844, 3836], '1': [1845, 3629, 3837, 4200, 4609, 4615], '2': [1847], 'receptors': [1848, 4448], 'stress,': [1851, 3103, 3983, 4171, 4394], 'SODs': [1856], 'expression.': [1857], 'Am': [1858, 1934, 2015, 2114, 2162, 2243, 2356, 2401, 2495, 2802, 3009, 3036, 3241, 3282, 3349, 3517, 3560], 'J': [1859, 1935, 1968, 2016, 2115, 2163, 2205, 2244, 2357, 2400, 2496, 2803, 2947, 3010, 3037, 3240, 3283, 3350, 3478, 3518, 3561], 'Physiol': [1860, 1864, 1936, 1940, 2017, 2020, 2116, 2119, 2164, 2167, 2245, 2248, 2358, 2361, 2497, 2500, 2804, 2806, 3011, 3014, 3038, 3042, 3284, 3287, 3351, 3354, 3431, 3519, 3522, 3562, 3565], 'Regul': [1861, 1937, 3039], 'Integr': [1862, 1938, 3040], 'Comp': [1863, 1939, 3041], '285:': [1865, 2120, 3015], 'R117–R124,': [1866], '2003.Link': [1867, 1943, 2122, 3017], '|': [1868, 1870, 1909, 1944, 1946, 1973, 1975, 1977, 2024, 2026, 2051, 2053, 2055, 2078, 2080, 2082, 2123, 2125, 2171, 2173, 2210, 2212, 2214, 2252, 2254, 2282, 2284, 2286, 2319, 2321, 2323, 2365, 2367, 2407, 2409, 2411, 2448, 2450, 2452, 2504, 2506, 2538, 2540, 2574, 2576, 2578, 2616, 2618, 2620, 2644, 2646, 2648, 2683, 2685, 2687, 2712, 2714, 2716, 2742, 2744, 2746, 2782, 2784, 2810, 2812, 2842, 2844, 2846, 2890, 2892, 2894, 2953, 2955, 2957, 2984, 2986, 2988, 3018, 3020, 3046, 3048, 3089, 3091, 3093, 3118, 3120, 3122, 3140, 3142, 3172, 3174, 3196, 3198, 3200, 3247, 3249, 3251, 3291, 3293, 3322, 3324, 3326, 3358, 3360, 3387, 3389, 3391, 3412, 3414, 3416, 3436, 3438, 3459, 3461, 3463, 3484, 3486, 3488, 3526, 3528, 3569, 3571, 3634, 3663, 3680, 3696, 3744, 3771, 3814, 3853, 3951, 3970, 4019, 4063, 4111, 4158, 4219, 4301, 4374, 4419, 4478, 4506, 4544, 4574], 'ISI': [1869, 1945, 1976, 2025, 2054, 2081, 2124, 2172, 2213, 2253, 2285, 2322, 2366, 2410, 2451, 2505, 2577, 2619, 2647, 2686, 2715, 2745, 2783, 2811, 2845, 2893, 2956, 2987, 3019, 3047, 3092, 3121, 3173, 3199, 3250, 3292, 3325, 3359, 3390, 3415, 3462, 3487, 3527, 3570], 'Google': [1871, 1910, 1947, 1978, 2027, 2056, 2083, 2126, 2174, 2215, 2255, 2287, 2324, 2368, 2412, 2453, 2507, 2541, 2579, 2621, 2649, 2688, 2717, 2747, 2785, 2813, 2847, 2895, 2958, 2989, 3021, 3049, 3094, 3123, 3143, 3175, 3201, 3252, 3294, 3327, 3361, 3392, 3417, 3439, 3464, 3489, 3529, 3572], 'Scholar2': [1872], 'Tojo': [1875], 'Onozato': [1877], 'M,': [1878, 2088, 2139, 2663], 'Quinn': [1881, 2293], 'MT,': [1882, 2294], 'Fujita': [1883], 'Expression': [1890], 'localization': [1893], 'classic': [1895], 'subunits': [1898], 'spontaneously': [1901, 3310], 'hypertensive': [1902, 2833, 3311], 'Hypertension': [1905, 2047, 2444, 2640, 2738, 3114], '39:': [1906, 3481], '269–274,': [1907], '2001.ISI': [1908], 'Scholar3': [1911], 'AW': [1913, 2631, 2723], 'Jr,': [1914, 2659, 2857, 2903, 3059], 'Mattson': [1917, 2818], 'D,': [1918, 3204, 3301], 'Zou': [1920, 2511, 2627], 'AP.': [1921], 'Role': [1922, 2431, 2792, 2820, 2969, 3218, 3738], 'medullary': [1931, 2635], 'flow.': [1933], '284:': [1941], 'R1355–R1369,': [1942], 'Scholar4': [1948], 'De': [1949], 'Vriese': [1950], 'AS,': [1951], 'Verbeuren': [1952], 'TJ,': [1953], 'Van': [1954], 'de': [1955], 'Voorde': [1956], 'Lameire': [1958], 'NH,': [1959], 'Vanhoutte': [1961], 'PM.': [1962], 'Endothelial': [1963, 2036, 3616], 'diabetes.': [1966], 'Br': [1967, 2204], 'Pharmacol': [1969, 2206, 2534, 3167], '130:': [1970], '963–974,': [1971], '2000.Crossref': [1972, 2537, 3139, 3195], 'PubMed': [1974, 2052, 2079, 2211, 2283, 2320, 2408, 2449, 2539, 2575, 2617, 2645, 2684, 2713, 2743, 2843, 2891, 2954, 2985, 3090, 3119, 3141, 3197, 3248, 3323, 3388, 3413, 3437, 3460, 3485], 'Scholar5': [1979], 'CM,': [1981, 2911], 'Shi': [1982, 2851, 2899, 3051], 'Y,': [1983, 2335, 2375, 2544, 2582, 2656, 2852, 2900, 2961, 3052, 3206], 'Hutchins': [1984], 'WC,': [1985], 'Su': [1986, 2866, 3055], 'Gross': [1988], 'GJ,': [1989], 'Ostadal': [1990], 'B,': [1991, 2133, 2460, 2588], 'Tweddell': [1992, 2858, 2912, 3060], 'JS,': [1993, 2859, 2913, 3061], 'Baker': [1995, 2869, 2921, 3063], 'JE.': [1996, 2870, 2922, 3064], 'Cardioprotection': [1997], 'hypoxic': [2000, 2877, 4345], 'rabbits': [2001, 3072, 3235], 'persists': [2002], 'upon': [2003], 'normoxia:': [2006], 'KATP': [2013], 'channels.': [2014, 2678, 3082], 'Heart': [2018, 2117, 2165, 2246, 2359, 2498, 3012, 3285, 3352, 3520, 3563], 'Circ': [2019, 2118, 2166, 2247, 2360, 2499, 2569, 2611, 2777, 3013, 3286, 3353, 3521, 3564], '288:': [2021, 2168, 2249, 2362, 2501, 3288, 3355, 3523, 3566], 'H62–H68,': [2022], '2005.Link': [2023, 2170, 2251, 2364, 2503, 3290, 3357, 3525, 3568], 'Scholar6': [2028], 'Goligorsky': [2029], 'MS,': [2030, 3467], 'Chen': [2031, 2374, 3205], 'Brodsky': [2034], 'diabetic': [2041, 3599, 3659, 3767, 3829, 3915], 'nephropathy.': [2042], 'Focus': [2043], 'oxide.': [2046], '37:': [2048], '744–748,': [2049], '2001.Crossref': [2050, 2682, 2983, 3386, 3458], 'Scholar7': [2057], 'Griendling': [2058, 2298, 2477, 3267], 'KK': [2059], 'FitzGerald': [2061], 'GA.': [2062], 'Oxidative': [2063, 3127, 3446, 3609, 3740, 4142, 4316], 'injury.': [2067], 'Part': [2068], 'II.': [2069, 2443, 3239], 'Animal': [2070], 'studies.': [2073], 'Circulation': [2074, 2679, 2886], '108:': [2075], '2034–2040,': [2076], '2003.Crossref': [2077, 2281, 2406, 2615, 2643, 2741, 2781, 2952, 3246, 3321, 3435], 'Scholar8': [2084], 'SA,': [2086, 2129, 3469], 'Arshad': [2087], 'Viola': [2089], 'Kaminski': [2091, 2130, 2751], 'PM,': [2092, 2131, 2752], 'Ungvari': [2093], 'Z,': [2094, 3492, 3498, 3532], 'Rabbani': [2095], 'G,': [2096, 2224, 2468, 2476, 3536], 'Koller': [2097], 'Wolin': [2100, 2143, 2754, 3466], 'MS.': [2101, 2144, 2755], 'Pentose': [2102], 'phosphate': [2103], 'coordinates': [2105], 'redox-controlled': [2107], 'arteries.': [2113, 2161, 2610], 'H2316–H2326,': [2121], 'Scholar9': [2127], 'Floyd': [2132], 'Agarwal': [2134], 'R,': [2135, 3502], 'Ali': [2136], 'N,': [2137, 2462, 2510], 'Ahmad': [2138], 'Edwards': [2140], 'Cystolic': [2145], 'regulate': [2148], 'basal': [2151], 'Nox': [2152], 'oxidase-derived': [2153], 'H13–H21,': [2169], 'Scholar10': [2175], 'Halliwell': [2176], 'B': [2177], 'Whiteman': [2179], 'M.': [2180, 3181, 4002, 4212, 4288, 4297, 4404, 4415, 4467], 'Measuring': [2181], 'vivo': [2188], 'culture:': [2192], 'how': [2193], 'should': [2194], 'you': [2195], 'do': [2196, 2200], 'what': [2199, 3109], 'results': [2202], 'mean?': [2203], '142:': [2207], '231–255,': [2208], '2004.Crossref': [2209, 2318, 2711, 3088, 3117], 'Scholar11': [2216], 'OA,': [2218, 2258], 'Binion': [2219, 2259], 'DG,': [2220, 2260, 3265], 'Miura': [2221, 2651], 'H,': [2222, 2327, 2417, 2425, 2458, 2550, 2584, 2586, 2652, 2905, 3299, 3334], 'Telford': [2223], 'Otterson': [2225, 2261], 'MF,': [2226, 2262], 'Gutterman': [2228, 2264, 2554, 2592, 2665, 2996], 'DD.': [2229, 2265, 2555, 2593, 2666, 2997], 'hydrogen': [2233, 4283], 'peroxide': [2234], 'ACh-induced': [2236], 'dilation': [2237, 2605, 2668, 3000], 'microvessels.': [2242], 'H48–H54,': [2250], 'Scholar12': [2256], 'Acquired': [2266], 'inflammatory': [2270, 4204], 'bowel': [2271], 'disease:': [2272, 3601], 'loss': [2273], 'oxide-mediated': [2276], 'vasodilation.': [2277], 'Gastroenterology': [2278], '125:': [2279], '58–69,': [2280], 'Scholar13': [2288], 'Hilenski': [2289], 'LL,': [2290], 'Clempus': [2291], 'RE,': [2292, 2654], 'Lambeth': [2295], 'JD,': [2296], 'KK.': [2299, 3268], 'Distinct': [2300], 'subcellular': [2301], 'localizations': [2302], 'Nox1': [2304], 'Nox4': [2306], 'Arterioscler': [2312], 'Thromb': [2313], 'Vasc': [2314, 3479], 'Biol': [2315, 2948, 3454], '24:': [2316, 2709], '677–683,': [2317], 'Scholar14': [2325], 'Pesce': [2328], 'Zheng': [2330], 'W,': [2331, 3540], 'Kim': [2332], 'Zhang': [2334, 3531], 'Menini': [2336], 'Haywood': [2338], 'JR,': [2339], 'Sandberg': [2341], 'K.': [2342], 'Sex': [2343], 'wrap': [2354], 'hypertension.': [2355, 2639, 3133], 'H43–H47,': [2363], 'Scholar15': [2369], 'Salt': [2387, 3735], 'intake,': [2388], 'dismutase.': [2399], 'Soc': [2402, 3242], 'Nephrol': [2403, 2708, 2837, 3243], '14:': [2404, 3244], '2775–2782,': [2405], 'Scholar16': [2413], 'Landmesser': [2414], 'U,': [2415], 'Cai': [2416, 2457], 'Dikalov': [2418, 2471], 'McCann': [2420, 2465], 'L,': [2421, 2466, 3212], 'Hwang': [2422], 'Jo': [2424], 'Holland': [2426], 'SM,': [2427], 'Harrison': [2429, 2480, 3264], 'DG.': [2430, 2481], 'p47(phox)': [2433], 'caused': [2440, 4433], 'angiotensin': [2442, 3160, 3715, 4450], '40:': [2445], '511–515,': [2446], '2002.Crossref': [2447, 2573, 2841, 2889, 3411, 3483], 'Scholar17': [2454], 'KM,': [2456, 3261], 'Fink': [2459], 'Hoch': [2461], 'DS,': [2464, 3255], 'Kojda': [2467], 'Fukai': [2469], 'Ramasamy': [2473], 'Gamez': [2475], 'KK,': [2478], 'Hemodynamic': [2482], 'biochemical': [2484], 'adaptations': [2485], 'vaxcular': [2487], 'overexpression': [2490], 'H7–H12,': [2502], 'Scholar18': [2508], 'Li': [2509, 2518, 2549, 2585], 'AP,': [2512, 2628], 'Ge': [2513], 'ZD,': [2514], 'Campbell': [2515], 'WB,': [2516], 'PL.': [2519], 'Effect': [2520], 'nitrix': [2522], 'calcium-induced': [2525], 'calcium': [2526], 'arterial': [2530], 'muscle.': [2532, 3281], 'Gen': [2533], '35:': [2535], '37–45,': [2536], 'Scholar19': [2542], 'Liu': [2543, 2581, 2655], 'Terata': [2545], 'K,': [2546, 2863, 2917, 3534], 'Chai': [2547], 'Q,': [2548], 'Kleinman': [2551], 'LH,': [2552], 'Peroxynitrite': [2556], 'inhibits': [2557], 'Ca2+-activated': [2558, 2676], 'K+': [2559, 2677], 'channel': [2560], 'arterioles.': [2568, 3008], 'Res': [2570, 2612, 2778, 3084, 3191, 3480], '91:': [2571], '1070–1076,': [2572], 'Scholar20': [2580], 'Zhao': [2583], 'Kalyanaraman': [2587], 'Nicolosi': [2589], 'AC,': [2590], 'Mitochondrial': [2594], 'sources': [2595], 'play': [2599], 'flow-mediated': [2604], '93:': [2613], '573–580,': [2614], 'Scholar21': [2622], 'Makino': [2623], 'Skelton': [2625], 'MM,': [2626], 'Jr.': [2632, 2724], 'Increased': [2633], 'leads': [2637], '42:': [2641, 2739], '25–30,': [2642], 'Scholar22': [2650], 'Watchtel': [2653], 'Loberiza': [2657], 'FR': [2658], 'Saito': [2660], 'Muira': [2662], 'Flow-induced': [2667], 'arterioles:': [2672], '103:': [2680], '1992–1998,': [2681], 'Scholar23': [2689], 'Modlinger': [2690], 'P,': [2691, 2850, 2898, 3054, 3257, 3496], 'CS,': [2693, 3544], 'Nitric': [2697], 'oxide,': [2698], 'progression': [2702], 'failure.': [2706], 'Semin': [2707], '354–365,': [2710], 'Scholar24': [2718], 'T': [2720], 'Angiotensin': [2725, 3269], 'II-NAD(P)H': [2726], 'oxidase-stimulated': [2727], '588–593,': [2740], 'Scholar25': [2748], 'Oeckler': [2749, 3471], 'RA,': [2750, 2909, 3506], 'Stretch': [2756], 'contraction': [2758], 'NAD(P)': [2765], 'oxidase-medicated': [2766], 'signal-regulated': [2771], 'kinase': [2772, 2775], 'mitogen-activated': [2773], 'protein': [2774, 2873, 2928, 2945, 3078], 'cascade.': [2776], '92:': [2779], '24–31,': [2780], 'Scholar26': [2786], 'Ortiz': [2787], 'PA': [2788], 'Garvin': [2790, 2962], 'JL.': [2791], 'nephron': [2800], 'transport.': [2801], 'Renal': [2805, 3305, 3930, 4258], '282:': [2807, 3043], 'F777–F784,': [2808], '2002.Link': [2809, 3045], 'Scholar27': [2814], 'TL': [2816], 'DL.': [2819], 'medulla': [2829], 'kidneys.': [2834], 'Curr': [2835, 3134, 3406], 'Opin': [2836], 'Hypertens': [2838, 3135, 3407], '11:': [2839], '93–98,': [2840], 'Scholar28': [2848], 'Rafiee': [2849, 2897, 3053], 'Kong': [2853], 'X,': [2854], 'Pritchard': [2855, 2901, 3057], 'KA': [2856, 2902, 3058], 'Litwin': [2860, 2914], 'SB,': [2861, 2915], 'Mussatto': [2862, 2916], 'Jaquiss': [2864, 2918], 'RD,': [2865, 2919], 'Activation': [2871], 'kinases': [2874, 3079], 'infant': [2878, 3071], 'rabbit': [2881, 2933], 'hearts:': [2882], 'cardioprotection.': [2885], '106:': [2887], '239–245,': [2888], 'Scholar29': [2896], 'Ogawa': [2904], 'Eis': [2906], 'AL,': [2907], 'Komorowski': [2908], 'Cellular': [2923, 3817, 4116, 4306, 4511, 4549], 'redistribution': [2924], 'Hsp70': [2927], 'hypoxia:': [2942], 'kinases.': [2946], 'Chem': [2949], '278:': [2950, 3193], '43636–43644,': [2951], 'Scholar30': [2959], 'Ren': [2960], 'JL,': [2963], 'Ito': [2964], 'Carretero': [2967], 'OA.': [2968], 'neuronal': [2971], 'macula': [2977], 'densa.': [2978], 'Int': [2980, 3318, 3383], '60:': [2981], '1676–1683,': [2982], 'Scholar31': [2990], 'Sato': [2991], 'Sakuma': [2993], 'I,': [2994], 'Mechanism': [2998], 'H2345–H2354,': [3016], 'Scholar32': [3022], 'Schnackenberg': [3023], 'CG.': [3024], 'Physiological': [3025, 4605], 'roles': [3028], 'radical': [3031], 'microvasculature.': [3035], 'R335–R342,': [3044], 'Scholar33': [3050], 'Acute': [3065], 'cardioprotective': [3066], 'erythropoietin': [3069], 'mediated': [3074], 'Basic': [3083], 'Cardiol': [3085], '99:': [3086], '173–182,': [3087], 'Scholar34': [3095], 'Touyz': [3096, 3125, 3145], 'RM.': [3097, 3126], 'Reactive': [3098, 3396], 'species,': [3100], 'hypertension:': [3108, 4435], 'clinical': [3112], 'significance?': [3113], '44:': [3115], '248–252,': [3116], 'Scholar35': [3124], 'Rep': [3136, 3408], '2:': [3137], '98–105,': [3138], 'Scholar36': [3144], 'RM': [3146], 'Schiffrin': [3148], 'EL.': [3149], 'Signal': [3150], 'transduction': [3151], 'mediating': [3153], 'actions': [3158], 'Rev': [3168], '52:': [3169], '639–672,': [3170], '2000.PubMed': [3171], 'Scholar37': [3176], 'Ullrich': [3177], 'V': [3178], 'Bachschmid': [3180], 'Superoxide': [3182, 3473], 'messenger': [3185], 'function.': [3188, 3405], 'Biochem': [3189], 'Biophys': [3190], 'Commun': [3192], '1–8,': [3194], 'Scholar38': [3202], 'Wang': [3203, 3497], 'Borrego': [3211], 'Umans': [3213], 'Ang': [3229, 3238, 3549], 'infused': [3236], '2783–2789,': [3245], 'Scholar39': [3253], 'Rocic': [3256], 'Mellis': [3258], 'AM,': [3259], 'Lyle': [3262], 'potentiated': [3273], 'H37–H42,': [3289], 'Scholar40': [3295], 'Baumgärtl': [3298], 'Lübbers': [3300], 'oxygenation': [3306], 'defects': [3307, 3341], 'rat:': [3312], 'AT1': [3315, 3368, 4447], 'receptors.': [3316], '63:': [3319], '202–208,': [3320], 'Scholar41': [3328], 'Xie': [3333], 'Angiotensin-induced': [3340], 'oxygenation:': [3344], 'H22–H28,': [3356], 'Scholar42': [3362], 'WJ': [3364], 'antagonist': [3370], 'combats': [3371], 'restores': [3375], 'SHR.': [3381], '59:': [3384], '1257–1263,': [3385], 'Scholar43': [3393], 'species:': [3398], '4:': [3409], '160–166,': [3410], 'Scholar44': [3418], 'Redox': [3421], 'arteriole': [3426], 'tubuloglomerular': [3428], 'feedback.': [3429], 'Acta': [3430, 3681], 'Scand': [3432], '179:': [3433], '217–223,': [3434], 'Scholar45': [3440], 'CS': [3442], 'WJ.': [3445], 'stress:': [3447], 'cause': [3448], 'consequence': [3450], 'hypertension?': [3452], 'Exp': [3453], 'Med': [3455], '226:': [3456], '619–620,': [3457], 'Scholar46': [3465], 'RA.': [3472], 'system.': [3477], '191–207,': [3482], 'Scholar47': [3490], 'Asico': [3493], 'LD,': [3494], 'Yu': [3495], 'Jones': [3499], 'JE,': [3500], 'Bai': [3501], 'Sibley': [3503], 'DR,': [3504], 'Felder': [3505], 'Jose': [3508], 'PA.': [3509], 'D5': [3510], 'D.': [3516, 4358, 4461], 'H55–H61,': [3524], 'Scholar48': [3530], 'Rhinehart': [3533], 'Solis': [3535], 'Pittner': [3537], 'Kwon': [3539], 'TL.': [3547], 'Chronic': [3548, 4153], 'descending': [3557], 'recta.': [3559], 'H29–H36,': [3567], 'Scholar': [3573], 'Download': [3574], 'Previous': [3576], 'Back': [3577], 'Top': [3579], 'Next': [3580], 'FiguresReferencesRelatedInformation': [3581], 'Cited': [3582], 'ByAssessment': [3583], 'using': [3587], 'novel': [3589], 'Flow': [3591], 'Mediated': [3592], 'Skin': [3593], 'Fluorescence': [3594], '(FMSF)': [3595], 'patients': [3597], 'preliminary': [3603], 'studyMicrovascular': [3604], 'Research,': [3605], 'Vol.': [3606, 3638, 3668, 3683, 3698, 3729, 3746, 3776, 3795, 3819, 3859, 3878, 3899, 3918, 3938, 3956, 3973, 4025, 4069, 4120, 4137, 4163, 4190, 4227, 4246, 4264, 4310, 4338, 4379, 4425, 4440, 4484, 4515, 4553, 4583], '144Changes': [3607], 'Nitrosative': [3611], 'Stress': [3612, 3687, 4143], 'Indicators': [3613], 'Vascular': [3615, 4319, 4324], 'Growth': [3617], 'Factor': [3618], 'After': [3619], 'Maximum-Intensity': [3620], 'Exercise': [3621], 'Assessing': [3622], 'Aerobic': [3623], 'Capacity': [3624, 4148], 'Males': [3626], 'With': [3627, 3867, 4256], 'Type': [3628], 'Diabetes': [3630], 'Mellitus6': [3631], 'August': [3632], '2021': [3633], 'Frontiers': [3635], 'Physiology,': [3637, 3858, 4024, 4068, 4119, 4226, 4309, 4378, 4424, 4483, 4514, 4552, 4582], '12Musa': [3639], 'paradisiaca': [3640], 'L.': [3641], 'leaf': [3642], 'fruit': [3644], 'peel': [3645], 'hydroethanolic': [3646], 'extracts': [3647], 'improved': [3648], 'profile,': [3651], 'glycemic': [3652], 'index': [3653], 'nicotinamide/streptozotocin‐induced': [3658], 'rats5': [3660], 'December': [3661, 3968, 4156, 4372], '2020': [3662, 3679, 3695], 'Veterinary': [3664], 'Medicine': [3665], 'Science,': [3667], '7,': [3669], 'No.': [3670, 3685, 3700, 3731, 3748, 3778, 3797, 3821, 3861, 3880, 3901, 3920, 3958, 3975, 4027, 4071, 4122, 4139, 4165, 4192, 4229, 4248, 4266, 4312, 4340, 4381, 4427, 4442, 4486, 4517, 4555, 4585], '2Reactive': [3671], 'function8': [3677], 'Physiologica,': [3682], '229,': [3684], '4Nitrosative': [3686], 'Its': [3689], 'Association': [3690], 'Cardiometabolic': [3692], 'Disorders31': [3693], 'Molecules,': [3697], '25,': [3699], '11The': [3701], 'estradiol': [3704], 'testosterone': [3706], 'injection': [3713], 'female': [3718], 'doca': [3719], '–': [3720], 'salt': [3721], 'treated': [3722], 'ratsHormone': [3723], 'Molecular': [3724, 3815, 4118, 4308, 4513, 4551], 'Biology': [3725, 4320], 'Clinical': [3727, 3952], 'Investigation,': [3728], '3Na/K-ATPase': [3732], 'Signaling': [3733], 'Sensitivity:': [3736], 'Stress2': [3741], 'March': [3742, 3754, 3812], '2017': [3743], 'Antioxidants,': [3745], '6,': [3747], '1Fetal': [3749], 'Programming': [3750], 'Pathology16': [3753], '2015Protective': [3755], 'saffron': [3758], '(its': [3759], 'constituent,': [3761], 'crocin)': [3762], 'nephropathy': [3764, 3830], 'streptozotocin-induced': [3766, 4132], 'rats12': [3768], 'June': [3769, 4476], '2014': [3770, 3813, 3852], 'Human': [3772], 'Experimental': [3774, 3954], 'Toxicology,': [3775, 4245], '2Direct': [3779], 'Radical': [3780], 'Scavenging': [3781], 'Activity': [3782], 'Benzbromarone': [3784], 'Provides': [3785], 'Beneficial': [3786], 'Antioxidant': [3787, 4147], 'Properties': [3788], 'Hyperuricemia': [3790], 'TreatmentBiological': [3791], 'Pharmaceutical': [3793, 4336], 'Bulletin,': [3794, 4337], '38,': [3796], '3Therapeutic': [3798], 'stem': [3801], 'hyperglycemia,': [3804], 'hyperlipidemia,': [3805], 'alloxan-treated': [3810], 'rats7': [3811], 'Biochemistry,': [3818, 3898], '391,': [3820], '1-2Differences': [3822], 'susceptibility': [3824], 'develop': [3826], 'parameters': [3827], 'four': [3832], 'strains': [3834], 'diabetesStephanie': [3838], 'Franzén,': [3839], 'Malou': [3840], 'Friederich-Persson,': [3841], 'Angelica': [3842], 'Fasching,': [3843], 'Peter': [3844], 'Hansell,': [3845], 'Masaomi': [3846], 'Nangaku,': [3847], 'Fredrik': [3849], 'Palm15': [3850], 'Physiology-Renal': [3857, 4023, 4067, 4482], '306,': [3860], '10Urinary': [3862], 'Proteome': [3863], 'Analysis': [3864], 'Patients': [3866], 'Stable': [3868], 'SFU': [3869], 'Grade': [3870], '4': [3871, 4586], 'Ureteropelvic': [3872], 'Junction': [3873], 'Obstruction': [3874], 'Differs': [3875], 'From': [3876], 'NormalUrology,': [3877], '82,': [3879], '3Ameliorative': [3881], 'effect': [3882, 3903, 4126], '20-OH': [3884], 'ecdysone': [3885], 'streptozotocin': [3887], 'induced': [3888, 3914, 4036, 4275], 'β-cell': [3892], 'experimental': [3895, 4038], 'hyperglycemic': [3896], 'ratsProcess': [3897], '47,': [3900], '12Ameliorative': [3902], 'diosmin,': [3905], 'citrus': [3907], 'flavonoid': [3908], 'streptozotocin-nicotinamide': [3910], 'ratsChemico-Biological': [3916], 'Interactions,': [3917], '195,': [3919], '1Reactive': [3921, 4313], 'Oxygen': [3922, 3940, 4314], 'Species': [3923, 3941], 'Modulation': [3924], 'Na/K-ATPase': [3926], 'Regulates': [3927], 'Fibrosis': [3928], 'Proximal': [3931], 'Tubular': [3932], 'Sodium': [3933], 'HandlingInternational': [3934], 'Nephrology,': [3937, 4162], '2012Reactive': [3939], 'Dopamine': [3943], 'Receptor': [3944], 'Function': [3945], 'Essential': [3947], 'Hypertension3': [3948], 'July': [3949], '2009': [3950], 'Hypertension,': [3955, 4189], '2Chemistry': [3959], 'Antihypertensive': [3961], 'Tempol': [3964], 'Other': [3966], 'Nitroxides26': [3967], '2008': [3969, 4018, 4062, 4110], 'Pharmacological': [3971], 'Reviews,': [3972], '60,': [3974], '4Treatment': [3976, 4193], 'pyrrolidine': [3978], 'dithiocarbamate': [3979], 'improves': [3980], 'proteinuria,': [3981], 'glomerular': [3985], 'overload': [3988], 'proteinuriaEdilia': [3989], 'Tapia,': [3990, 4045], 'Dolores': [3991], 'J.': [3992, 4005, 4059, 4354, 4360, 4365], 'Sánchez-González,': [3993], 'Omar': [3994], 'N.': [3995, 4369], 'Medina-Campos,': [3996], 'Virgilia': [3997, 4042], 'Soto,': [3998, 4043], 'Carmen': [3999, 4046], 'Ávila-Casado,': [4000], 'Claudia': [4001], 'Martínez-Martínez,': [4003], 'Richard': [4004, 4058, 4209], 'Johnson,': [4006], 'Bernardo': [4007, 4055], 'Rodríguez-Iturbe,': [4008, 4056], 'José': [4009], 'Pedraza-Chaverrí,': [4010], 'Martha': [4011, 4053], 'Franco,': [4012, 4054], 'Laura': [4014], 'G.': [4015, 4040], 'Sánchez-Lozada1': [4016], 'November': [4017, 4542], '295,': [4026, 4070], '5Role': [4028], 'abnormalities': [4035], 'hyperuricemiaLaura': [4039], 'Sánchez-Lozada,': [4041], 'Edilia': [4044], 'Avila-Casado,': [4047], 'Yuri': [4048], 'Y.': [4049], 'Sautin,': [4050], 'Takahiko': [4051], 'Nakagawa,': [4052], 'Johnson1': [4060], 'October': [4061, 4572], '420-HETE': [4072], 'activates': [4077], 'NAPDH': [4078], 'artery': [4082], 'cellsMeetha': [4084], 'Medhora,': [4085], 'Yuenmu': [4086], 'Chen,': [4087], 'Stephanie': [4088], 'Gruenloh,': [4089], 'Daniel': [4090], 'Harland,': [4091], 'Sreedhar': [4092], 'Bodiga,': [4093], 'Jacek': [4094], 'Zielonka,': [4095], 'Debebe': [4096], 'Gebremedhin,': [4097], 'Ying': [4098], 'Gao,': [4099], 'John': [4100], 'R.': [4101, 4107, 4370], 'Falck,': [4102], 'Siddam': [4103], 'Anjaiah,': [4104], 'Elizabeth': [4106], 'Jacobs1': [4108], 'Physiology-Lung': [4115, 4305, 4510, 4548], '294,': [4121], '5Antioxidant': [4123], 'pancreas-protective': [4125], 'aucubin': [4128], 'diabetesEuropean': [4133], 'Pharmacology,': [4136], '582,': [4138], '1-3Increase': [4140], 'Not': [4145], 'Advancing': [4150], 'Stages': [4151], 'Disease7': [4155], '2007': [4157, 4218, 4300], '28,': [4164], '3A': [4166], 'vitamin-E-fortified': [4167], 'diet': [4168], 'sympathetic': [4172], 'nerve': [4173], 'phenol-renal': [4179], 'ratsJournal': [4183], 'Society': [4187], '1,': [4191], 'BX471,': [4195], 'CC': [4197], 'chemokine': [4198], 'antagonist,': [4201], 'attenuates': [4202], 'systemic': [4203, 4352], 'sepsisMin': [4207], 'He,': [4208], 'Horuk,': [4210], 'Shabbir': [4211], 'Moochhala,': [4213], 'Madhav': [4215], 'Bhatia1': [4216], 'April': [4217, 4504], 'Physiology-Gastrointestinal': [4223], 'Liver': [4225], '292,': [4228, 4311], '4Protective': [4230], 'quercetin': [4233], 'phenylhydrazine-induced': [4235], 'ratsFood': [4242], 'Chemical': [4244], '45,': [4247], '3Insulin': [4249], 'Resistance': [4250], 'Oxidant': [4252], 'Stress:': [4253], 'Interrelation': [4255], 'Deleterious': [4257], 'Consequences?Journal': [4259], 'CardioMetabolic': [4262], 'Syndrome,': [4263], '2,': [4265], '2Alterations': [4267], 'zinc': [4269], 'homeostasis': [4270], 'underlie': [4271], 'death': [4274], 'acute': [4280, 4530], 'peroxideDean': [4284], 'A.': [4285, 4361, 4366, 4401], 'Wiseman,': [4286, 4402], 'Sandra': [4287, 4403], 'Wells,': [4289, 4405], 'Maryann': [4290, 4408], 'Hubbard,': [4291, 4409], 'Jonathan': [4292, 4410], 'Welker,': [4294, 4412], 'Stephen': [4296, 4414], 'Black1': [4298, 4416], 'January': [4299, 4610, 4616], 'Species,': [4315], 'Stress,': [4317], 'HypertensionAntioxidant': [4322], 'Protective': [4325], 'Activities': [4326], 'Cratoxylum': [4328], 'formosum,': [4329], 'Syzygium': [4330], 'gratum': [4331], 'Limnophila': [4333], 'aromaticaBiological': [4334], '4Acute': [4341], 'lung': [4342, 4523, 4531], 'augments': [4344], 'ventilatory': [4346], 'absence': [4350], 'hypoxemiaF.': [4353], 'Jacono,': [4355], 'Y.-J.': [4356], 'Peng,': [4357], 'Nethery,': [4359], 'Faress,': [4362], 'Z.': [4363], 'Lee,': [4364], 'Kern,': [4367], 'Prabhakar1': [4371], '2006': [4373, 4418, 4477, 4505], 'Applied': [4377], '101,': [4380], '6Endothelial': [4382], 'exogenous': [4387], 'Zn2+': [4388], 'resembles': [4389], 'NO-mediated': [4392], 'nitrosative': [4393], 'protected': [4397], 'MT-1': [4399], 'overexpressionDean': [4400], 'Jason': [4406], 'Wilham,': [4407], 'September': [4417], 'Physiology-Cell': [4423], '291,': [4426], '3Mechanisms': [4428], 'target': [4430], 'Therapeutic': [4436], 'potentialPharmacology': [4437], 'Therapeutics,': [4439], '111,': [4441], '1Differential': [4443], 'congenic': [4458], 'mRen2.Lewis': [4459], 'ratKarl': [4460], 'Pendergrass,': [4462], 'B.': [4464, 4502], 'Averill,': [4465], 'Carlos': [4466], 'Ferrario,': [4468], 'Debra': [4469], 'I.': [4470], 'Diz,': [4471], 'Mark': [4473], 'C.': [4474], 'Chappell1': [4475], '290,': [4485, 4516], '6NF-κB': [4487], 'septic': [4494], 'shock': [4495], 'inflammationShu': [4497], 'Fang': [4498], 'Liu,': [4499], 'Asrar': [4501], 'Malik1': [4503], '4Sequential': [4518], 'recruitment': [4519], 'neutrophils': [4521], 'into': [4522], 'bronchoalveolar': [4525], 'lavage': [4526], 'fluid': [4527], 'LPS-induced': [4529], 'injuryJörg': [4532], 'Reutershan,': [4533], 'Abdul': [4534], 'Basit,': [4535], 'Elena': [4536], 'V.': [4537], 'Galkina,': [4538], 'Klaus': [4540], 'Ley1': [4541], '2005': [4543, 4573, 4601, 4611, 4617], '289,': [4554, 4584], '5Oxidative': [4556], 'deficiency': [4561], 'kidney:': [4564], 'critical': [4566], 'hypertension?Christopher': [4569], 'Wilcox11': [4571], 'Physiology-Regulatory,': [4578], 'Integrative': [4579], 'Comparative': [4581], 'issue': [4590], '>': [4591], 'Volume': [4592], '288Issue': [4593], '1January': [4594], '2005Pages': [4595], 'H3-H6': [4596], 'Copyright': [4597], 'PermissionsCopyright': [4599], '©': [4600], 'Societyhttps://doi.org/10.1152/ajpheart.00854.2004PubMed15598869History': [4606], 'Published': [4607, 4612], 'online': [4608], 'print': [4614], 'Metrics': [4618]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2058725632', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-17T11:43:25.301162', 'created_date': '2016-06-24'}
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