Mesalazine induced exacerbation of ulcerative colitis.

Name: Work Video:
Duration: 3 min 30 s
Description: 5-Aminosalicylic acid (5-ASA) compounds occasionally exacerbate diarrhoea in patients with inflammatory bowel disease. This is thought to be due to a secretory mechanism in most cases. A patient with presumed intolerance to sulphasalazine and 5-ASA preparations who developed endoscopic and histological evidence of disease relapse after a rectal challenge with mesalazine is reported.
Kapil Kapur; Geraint T. Williams; M C Allison
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'838', 'last_page': '839'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10134', 'display_name': 'Inflammatory Bowel Disease', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10134', 'display_name': 'Inflammatory Bowel Disease', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13569', 'display_name': 'Microscopic Colitis', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12538', 'display_name': 'Eosinophilic Esophagitis', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/mesalazine', 'display_name': 'Mesalazine', 'score': 0.98042417}, {'id': 'https://openalex.org/keywords/aminosalicylic-acid', 'display_name': 'Aminosalicylic acid', 'score': 0.8281369}, {'id': 'https://openalex.org/keywords/sulfasalazine', 'display_name': 'Sulfasalazine', 'score': 0.80791706}], 'concepts': [{'id': 'https://openalex.org/C2779174533', 'wikidata': 'https://www.wikidata.org/wiki/Q412479', 'display_name': 'Mesalazine', 'level': 4, 'score': 0.98042417}, {'id': 'https://openalex.org/C2776206795', 'wikidata': 'https://www.wikidata.org/wiki/Q2823237', 'display_name': 'Aminosalicylic acid', 'level': 2, 'score': 0.8281369}, {'id': 'https://openalex.org/C2780479503', 'wikidata': 'https://www.wikidata.org/wiki/Q1477', 'display_name': 'Ulcerative colitis', 'level': 3, 'score': 0.8242799}, {'id': 'https://openalex.org/C2777014857', 'wikidata': 'https://www.wikidata.org/wiki/Q1383410', 'display_name': 'Exacerbation', 'level': 2, 'score': 0.80939853}, {'id': 'https://openalex.org/C2779383735', 'wikidata': 'https://www.wikidata.org/wiki/Q420035', 'display_name': 'Sulfasalazine', 'level': 4, 'score': 0.80791706}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.78230196}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.73386776}, {'id': 'https://openalex.org/C2778260677', 'wikidata': 'https://www.wikidata.org/wiki/Q917447', 'display_name': 'Inflammatory bowel disease', 'level': 3, 'score': 0.64897203}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6156842}, {'id': 'https://openalex.org/C2775862500', 'wikidata': 'https://www.wikidata.org/wiki/Q2453464', 'display_name': 'Colitis', 'level': 2, 'score': 0.45572558}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.4137952}], 'mesh': [{'descriptor_ui': 'D000636', 'descriptor_name': 'Aminosalicylic Acids', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D000894', 'descriptor_name': 'Anti-Inflammatory Agents, Non-Steroidal', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D003093', 'descriptor_name': 'Colitis, Ulcerative', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000636', 'descriptor_name': 'Aminosalicylic Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000894', 'descriptor_name': 'Anti-Inflammatory Agents, Non-Steroidal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003093', 'descriptor_name': 'Colitis, Ulcerative', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003093', 'descriptor_name': 'Colitis, Ulcerative', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 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'https://openalex.org/W2411840308', 'https://openalex.org/W2472586266'], 'related_works': ['https://openalex.org/W2896896101', 'https://openalex.org/W2409330880', 'https://openalex.org/W2386497540', 'https://openalex.org/W2355129079', 'https://openalex.org/W2138179347', 'https://openalex.org/W2073759704', 'https://openalex.org/W206227929', 'https://openalex.org/W2060343300', 'https://openalex.org/W2058680921', 'https://openalex.org/W1497617769'], 'abstract_inverted_index': {'5-Aminosalicylic': [0], 'acid': [1], '(5-ASA)': [2], 'compounds': [3], 'occasionally': [4], 'exacerbate': [5], 'diarrhoea': [6], 'in': [7, 23], 'patients': [8], 'with': [9, 28, 49], 'inflammatory': [10], 'bowel': [11], 'disease.': [12], 'This': [13], 'is': [14, 51], 'thought': [15], 'to': [16, 19, 31], 'be': [17], 'due': [18], 'a': [20, 46], 'secretory': [21], 'mechanism': [22], 'most': [24], 'cases.': [25], 'A': [26], 'patient': [27], 'presumed': [29], 'intolerance': [30], 'sulphasalazine': [32], 'and': [33, 39], '5-ASA': [34], 'preparations': [35], 'who': [36], 'developed': [37], 'endoscopic': [38], 'histological': [40], 'evidence': [41], 'of': [42], 'disease': [43], 'relapse': [44], 'after': [45], 'rectal': [47], 'challenge': [48], 'mesalazine': [50], 'reported.': [52]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2058680921', 'counts_by_year': [{'year': 2020, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-11T11:37:55.832600', 'created_date': '2016-06-24'}
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