Publication Information

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176], 'This': [21, 177, 460, 1498, 2312], 'novel': [22, 178, 852], 'insect': [23, 179, 313, 588, 670, 853, 2777, 3168], 'cytokine': [24, 180, 854, 3169], 'consists': [25, 73, 181, 229, 538, 2526, 2538], '23': [27, 183, 543], 'amino': [28, 184, 544, 651], 'acid': [29, 185, 652], 'residues': [30, 62, 144, 186, 218, 300, 515, 727, 1897, 1944, 1985, 2066, 2135, 2143, 2188, 2483, 2687, 2762, 2873, 2893, 3068, 3113, 3151], 'and': [31, 79, 91, 129, 187, 235, 247, 285, 318, 333, 349, 352, 370, 398, 428, 595, 706, 728, 745, 754, 779, 785, 800, 814, 859, 923, 944, 985, 993, 1090, 1097, 1104, 1131, 1138, 1145, 1208, 1230, 1233, 1278, 1286, 1303, 1333, 1400, 1435, 1452, 1483, 1511, 1535, 1621, 1637, 1686, 1699, 1728, 1737, 1747, 1752, 1787, 1806, 1819, 1821, 1824, 2023, 2034, 2126, 2162, 2196, 2208, 2236, 2259, 2355, 2368, 2376, 2391, 2403, 2462, 2497, 2533, 2543, 2574, 2637, 2669, 2685, 2742, 2812, 2877, 2888, 2995, 3007, 3073, 3149, 3180, 3184, 3193, 3201], 'a': [32, 41, 75, 80, 92, 188, 197, 231, 236, 248, 422, 511, 729, 962, 1036, 1040, 1113, 1193, 1221, 1444, 1541, 1939, 1990, 2061, 2178, 2223, 2250, 2280, 2294, 2300, 2322, 2392, 2519, 2638, 2746, 3087, 3115], 'single': [33, 189], 'disulfide': [34, 190, 548, 1757, 2228, 2505, 2542, 2765], 'bond.': [35, 191, 549], 'Torsion': [36, 192], 'angle': [37, 193, 861, 1362, 1927, 2049, 2244], 'dynamics': [38, 194, 862, 1363, 1928, 2050, 2245], 'calculations': [39, 195, 1307], 'utilizing': [40, 196], 'total': [42, 198, 1064, 1275, 1558, 1703], '337': [44, 200, 1777], 'distance': [45, 201, 1721, 1740, 1778], 'constraints': [46, 202, 1487, 1722, 1741, 1779, 1791, 1999], 'yielded': [47, 203], 'an': [48, 54, 101, 204, 210, 257, 796, 1069, 2149, 2698, 2751, 2783, 2954, 3153], 'ensemble': [49, 205, 1536, 1606, 1922, 2044, 2090, 2122, 2139], '30': [51, 207, 1471, 1570, 1608, 1832, 1924, 2046, 2092, 2242], 'structures': [52, 208, 1538, 1561, 1609, 1805, 2416, 2548, 2733], 'with': [53, 107, 209, 263, 721, 989, 994, 1011, 1039, 1068, 1081, 1112, 1122, 1157, 1192, 1310, 1359, 1391, 1421, 1464, 1472, 1572, 1614, 1642, 2249, 2453, 2750], 'average': [55, 211, 1935, 2057, 2110, 2150, 2185, 2752], 'backbone': [56, 212, 881, 1267, 1887, 1975, 2160, 2195, 2257, 2707, 2753], 'root': [57, 213, 620, 646, 1631], 'mean': [58, 69, 214, 225, 482, 503, 621, 647, 1582, 1632, 1962, 2084, 2146, 2154, 2173, 2863], 'square': [59, 215, 483, 504, 622, 648, 1633], 'deviation': [60, 216, 484, 623, 649], 'for': [61, 146, 217, 302, 818, 1214, 1265, 1305, 1492, 1553, 1579, 1655, 1809, 1831, 1896, 1984, 2158, 2165, 2187, 2193, 2199, 2266, 2445, 2632, 2718, 2759, 2774, 2800, 2912, 2944, 2967, 3070, 3157, 3176, 3188, 3213], '7–22': [63, 219, 2189], '0.18': [65, 221, 2156], 'Å': [66, 222, 1761, 1768, 2157, 2164, 2192, 2198, 2758], 'structure.': [70, 226, 1627, 1701, 2521, 3133], 'disordered': [76, 232, 2369], 'N-terminal': [77, 233, 2523], 'region': [78, 234], 'well': [81, 237, 1442, 1696, 2133, 2301], 'defined': [82, 238, 1697, 2302, 2500], 'core': [83, 239, 2304], 'that': [84, 98, 240, 254, 424, 889, 1223, 2434, 2442, 2464, 2824, 2842, 2953], 'is': [85, 241, 390, 508, 580, 664, 739, 815, 885, 1782, 1794, 2103, 2210, 2220, 2363, 2620, 2678, 2820, 2965, 2971, 3152], 'stabilized': [86, 242, 2221], 'numerous': [88, 244], 'hydrophobic': [89, 245, 2237, 2303, 2892], 'interactions': [90, 135, 246, 291, 2827], 'short': [93, 249], 'β-hairpin.': [94, 250], 'Structural': [95, 251], 'comparisons': [96, 252], 'confirm': [97, 253], 'PSP1': [99, 128, 255, 284, 579, 655, 784, 791, 867, 884, 918, 1626, 1666, 1833, 2093, 2219, 2461, 2668, 2696, 2741, 2767, 2811, 2829, 3132], 'adopts': [100, 256], 'epidermal': [102, 258, 604, 630, 756, 2551], 'growth': [103, 259, 471, 492, 601, 605, 627, 631, 757, 2552], 'factor': [104, 260, 606, 632, 758, 2553], '(EGF)-like': [105, 261], 'fold': [106, 262], 'close': [108, 264], 'similarity': [109, 265, 659, 748, 2806], 'to': [110, 266, 316, 332, 556, 592, 660, 666, 783, 794, 803, 871, 888, 1198, 1201, 1259, 1479, 1530, 1539, 1650, 1754, 1960, 2082, 2152, 2177, 2345, 2408, 2441, 2680, 2745, 2795, 2822, 2833, 2938], 'C-terminal': [112, 268, 542, 873, 2536, 2690, 2814], 'subdomain': [113, 269, 874, 2525, 2537, 2692, 2815], 'EGF-like': [115, 271, 474, 495, 610, 636, 893, 2319, 2476, 2524, 2612, 2676, 2691, 2817], 'module': [116, 272], '5': [117, 273], 'human': [119, 275, 477, 498, 607, 613, 633, 639, 755, 897, 2550, 2946], 'thrombomodulin.': [120, 276], 'combination': [122, 278, 2224], 'three-dimensional': [125, 281, 848, 2412], 'extensive': [131, 287], 'literature': [132, 288], 'on': [133, 289, 432, 982, 1548, 2780, 2882, 2900, 3103, 3140, 3190], 'EGF-receptor': [134, 290], 'should': [136, 292], 'accelerate': [137, 293], 'process': [139, 295, 1499, 2785], 'identifying': [141, 297], 'specific': [143, 299], 'responsible': [145, 301, 2773], 'receptor': [147, 303, 2799, 2914, 2959], 'binding': [148, 304, 2960, 3078], 'activity': [149, 305, 559, 3142], 'this': [151, 307, 737, 780, 851, 1605, 2138, 2454, 2801, 2936, 3145, 3164], 'family': [152, 308, 2284, 2317, 2610, 2619, 2674], 'immunoregulatory': [154, 310], 'peptides.': [155, 311, 788, 3170], 'immune': [314, 402, 590], 'response': [315, 591, 802], 'parasites': [317], 'pathogens': [319], 'involves': [320], 'action': [322, 399], 'different': [324], 'classes': [325, 360, 668], 'blood': [327], 'cells': [328, 354, 403], '(hemocytes),': [329], 'which': [330, 1469, 1717, 2095, 2596], 'adhere': [331], 'spread': [334], 'across': [335], 'surface': [337], 'foreign': [339, 433, 2781], 'targets.': [340], 'In': [341, 1517, 3134], 'phylogenetically': [342], 'advanced': [343], 'insects': [344], 'like': [345, 368], 'Lepidoptera': [347], '(moths': [348], 'butterflies),': [350], 'plasmatocytes': [351, 431, 2779], 'granular': [353], 'are': [355, 2027, 2456, 2478, 2499, 2509, 2713, 2738, 2879, 2898], 'two': [357, 667, 725, 912, 2267, 2515, 2530, 2627, 2635], 'most': [358], 'important': [359, 2784], 'hemocytes': [362], 'involved': [363, 3076], 'in': [364, 698, 958, 1004, 1087, 1101, 1128, 1142, 1187, 1220, 1227, 1394, 1403, 1505, 1550, 1563, 1585, 1612, 1670, 1680, 1709, 1784, 1796, 1989, 2001, 2105, 2175, 2212, 2279, 2380, 2399, 2469, 2484, 2512, 2642, 2704, 2715, 2724, 2786, 2957, 2963, 2975, 3077, 3126, 3178], 'cellular': [365, 589, 2787, 2798], 'defense': [366], 'responses': [367], 'encapsulation': [369], 'clotting': [371], '(3Strand': [372, 404, 564], 'M.R.': [373, 405, 443, 521, 565, 679, 827], 'Pech': [374, 406, 440, 566, 676, 824], 'L.L.': [375, 407, 441, 567, 677, 825], 'Annu.': [376, 408, 568], 'Rev.': [377, 409, 569], 'Entomol.': [378, 410, 570], '1995;': [379, 411, 571, 1179, 1348], '40:': [380, 412, 572], '31-56Crossref': [381, 413, 573], 'PubMed': [382, 414, 455, 529, 574, 691, 774, 839, 1026, 1057, 1328, 1351, 1382, 1599, 2337, 2569, 2591, 2660, 3028, 3043, 3059], 'Scopus': [383, 415, 456, 530, 575, 692, 775, 840, 1027, 1058, 1329, 1352, 1383, 1600, 2338, 2570, 2592, 2661, 2854, 2927, 3044, 3060], '(599)': [384, 416, 576], 'Google': [385, 417, 458, 532, 577, 694, 777, 842, 1029, 1060, 1182, 1296, 1331, 1354, 1385, 1602, 2340, 2572, 2594, 2663, 2856, 2929, 3029, 3046, 3062], 'Scholar).': [386, 418, 459, 695, 843, 1030, 1061, 1183, 1253, 1297, 1355, 2664, 2857, 3063], 'However,': [387, 2948], 'relatively': [388], 'little': [389], 'known': [391], 'about': [392], 'factors': [394, 555], 'mediating': [395], 'movement': [397], 'these': [401, 2418, 2626, 2670, 2710, 3112], 'identification': [420], 'induces': [425], 'adhesion': [427, 801], 'surfaces': [434], 'was': [435, 792, 919, 933, 1009, 1033, 1076, 1117, 1218, 1500, 1528, 1610, 1648, 2277, 2768], 'reported': [437, 1622, 2443], '(1Clark': [438, 674, 822], 'K.D.': [439, 517, 675, 823], 'Strand': [442, 520, 678, 826], 'J.': [444, 680, 828, 1051, 1173, 1176, 1247, 1322, 1345, 1376, 1593, 2563, 2585, 2654, 3016, 3019], 'Biol.': [445, 681, 829, 1378, 2565, 2587, 2656, 3020], 'Chem.': [446, 682, 830, 3021], '1997;': [447, 683, 831, 1379, 2588, 2657], '272:': [448, 684, 832], '23440-23447Abstract': [449, 685, 833], 'Full': [450, 452, 686, 688, 834, 836, 3025], 'Text': [451, 453, 687, 689, 835, 837, 3026], 'PDF': [454, 690, 838, 3027], '(155)': [457, 693, 841], 'plasmatocyte-spreading': [461, 598, 624, 1658], '1The': [464, 485], 'abbreviations': [465, 486], 'PSP1plasmatocyte-spreading': [466, 487], '1GBPgrowth': [468, 489], 'blocking': [469, 490, 602, 628], 'peptideEGFepidermal': [470, 491], 'factorhEGFhuman': [472, 493], 'EGFhTM5fifth': [473, 494], 'domain': [475, 496, 611, 637, 878, 894, 1092, 1133, 1185], 'thrombomodulinNOEnuclear': [478, 499], 'Overhauser': [479, 500, 616, 642], 'effectNOESYNOE': [480, 501], 'spectroscopyRMSDroot': [481, 502], 'deviationof': [505], 'expressed': [509], 'as': [510, 1441, 1443, 1458, 1623, 2321, 2702, 2770], 'preproprotein': [512], '142': [514], '(2Clark': [516], 'Witherell': [518], 'A.': [519, 766, 1175, 1240, 3036], 'Biochem.': [522, 767, 1019], 'Biophys.': [523, 768, 1020], 'Res.': [524, 769, 1021], 'Commun.': [525, 770, 1022], '1998;': [526, 771, 2851, 2924], '250:': [527, 772], '479-485Crossref': [528], '(58)': [531], 'Scholar),': [533, 578, 778, 2341, 2595], 'but': [534, 663, 2695, 3118], 'mature': [536], 'only': [540, 741, 907], 'acids': [545], 'containing': [546, 964, 2486, 2518], 'one': [547, 2883], 'Although': [550, 2414, 3064], 'existence': [552], 'cytokine-like': [554], 'regulate': [557], 'hemocyte': [558], 'proposed': [562], 'previously': [563, 672], 'among': [581], 'first': [583, 2529, 2634], 'soluble': [584], 'mediators': [585], 'be': [593, 2406, 2438, 2792, 2831, 3081], 'purified': [594, 806, 924], 'functionally': [596], 'characterized.': [597], '1': [600, 626, 1660], 'EGF': [608, 634, 877, 2507, 2618, 2839, 2913, 2958], 'fifth': [609, 635, 892], 'thrombomodulin': [614, 640, 900], 'nuclear': [615, 641], 'effect': [617, 643], 'NOE': [618, 644, 1486, 1551, 1720, 1807, 1998, 2343], 'spectroscopy': [619, 645, 858, 1066, 1277, 1647], 'sequence': [653, 719, 734, 904, 1038], 'shows': [656, 868, 2860], 'no': [657, 2466], 'significant': [658, 2467], 'vertebrate': [661], 'cytokines,': [662], 'related': [665, 2419], 'peptides': [671, 709, 2420, 2479, 2712], 'As': [696, 1678, 2378], 'shown': [697, 793, 1679, 1795, 2104], 'Fig.1,': [699], 'growth-blocking': [701], '(GBP)': [703], 'ofPseudaletia': [704], 'separata': [705], 'paralytic': [708, 787, 2393], 'fromManduca': [710], 'sexta,': [711], 'Heliothis': [712], 'virescens,': [713], 'andSpodoptera': [714], 'exigua': [715], 'have': [716, 1667, 2421, 2597, 2843, 2951], 'high': [717, 927, 2748], '(>70%)': [718], 'identity': [720, 905, 932, 2666], 'PSP1,': [722, 1715, 2386, 2866, 3144], 'including': [723, 910, 2372, 2629, 2867, 2990, 3097], 'cysteine': [726, 2490], 'highly': [730, 2488], 'conserved': [731, 916, 2314, 2489, 2956], 'glycine.': [732], 'High': [733], 'variabilty': [735], 'within': [736, 2232, 2763], 'group': [738], 'found': [740, 2703], 'at': [742, 906, 979, 1078, 1119, 3210], 'positions': [743], '4': [744], '8.': [746], 'Some': [747], 'between': [749, 1744, 2120, 2625, 2667, 2807, 3001, 3067], 'sequences': [751, 2384], 'GBP': [753, 2387, 2432, 2463], 'suggested': [762], '(4Hayakawa': [763], 'Y.': [764], 'Ohnishi': [765], '194-199Crossref': [773], '(54)': [776], 'would': [781], 'extend': [782], 'Chemically': [789], 'synthesized': [790, 920, 1657], 'induce': [795], 'identical': [797], 'plasma': [809], 'P.': [811, 1319, 1342, 1371], 'larvae': [813], 'therefore': [816], 'suitable': [817], 'detailed': [819], 'structure-function': [820], 'analysis': [821, 1272, 1803, 2426], 'Here': [844], 'we': [845], 'report': [846], 'torsion': [860, 1361, 1926, 2048, 2243], 'calculations.': [863], 'clear': [869, 3083], 'homology': [870], 'family.': [879], 'conformation': [882], 'very': [886, 2400, 2439], 'similar': [887, 2440], 'anticoagulant': [898], 'protein': [899], '(hTM5),': [901], 'despite': [902, 2916], 'sharing': [903], 'four': [908], 'positions,': [909, 2402], 'cysteines': [913], 'disulfide.': [917], 'usingtert-butyloxycarbonyl': [921], 'chemistry': [922], 'reversed-phase': [926], 'performance': [928], 'liquid': [929], 'chromatography.': [930], 'Its': [931], 'confirmed': [934], 'matrix-assisted': [936], 'laser': [937], 'desorption/ionization': [938], 'time': [939, 1091, 1116, 1132], 'flight': [941], 'mass': [942], 'spectrometry': [943], 'NMR.': [945, 1053, 1178, 1324, 1347], 'sample': [948], 'consisted': [949], '2': [951], 'mg': [952], 'pure': [954], 'lyophilized': [955], 'peptide,': [956], 'dissolved': [957], '500': [959], 'μl': [960], 'buffer': [963], '90%': [965], 'H2O/10%': [966], 'D2O,': [967], '20': [968], 'mm': [969], 'sodium': [970], 'phosphate,': [971], 'pH': [972], '6.0.': [973], 'All': [974, 1149, 1254, 1628, 2241], 'spectra': [976, 1280], 'were': [977, 1155, 1190, 1257, 1268, 1308, 1357, 1419, 1456, 1477, 1515, 1577, 1640, 1707, 1723, 1742, 1800, 1881, 1969, 2247], 'recorded': [978], '10': [980], '°C': [981], 'Bruker': [983], 'DMX750': [984], 'DMX500': [986], 'spectrometers': [987], 'equipped': [988], 'triple-resonance': [990], '(1H/13C/15N)': [991], 'probes': [992], 'Z−': [995], 'or': [996, 1162, 1490, 1892, 1980, 2324], 'three–axis': [997], 'pulsed': [998], 'field': [999], 'gradient': [1000, 1413, 1619, 1958, 2080], 'capabilities.': [1001], 'Quadrature': [1002], 'detection': [1003], 'indirectly': [1006], 'detected': [1007], 'dimensions': [1008, 1089, 1130, 1189, 1256], 'obtained': [1010, 1269, 1309, 1801, 1937, 1951, 2059, 2073], 'States-TPPI': [1013], 'method': [1014], '(5Marion': [1015], 'D.': [1016, 2472], 'Wüthrich': [1017, 1320, 1343, 1374, 1591], 'K.': [1018, 1282, 1321, 1344, 1375, 1592], '1983;': [1023], '113:': [1024], '967-974Crossref': [1025], '(3514)': [1028], 'Water': [1031], 'suppression': [1032], 'achieved': [1034], 'using': [1035, 1387, 2459, 3191], 'watergate': [1037], '3-9-19': [1041], 'selective': [1042], 'inversion': [1043], 'pulse': [1044], '(6Piotto': [1045], 'M.': [1046, 1242, 1317, 1340, 1590, 2396, 3010], 'Saudek': [1047], 'V.': [1048, 1050], 'Sklenar': [1049], 'Biomol.': [1052, 1177, 1323, 1346], '1992;': [1054, 2566], '2:': [1055], '661-665Crossref': [1056], '(3487)': [1059], 'A': [1062, 1108, 1702, 1773, 2203], 'two-dimensional': [1063, 1109, 1711], 'correlation': [1065, 1276], 'spectrum': [1067, 1111, 1507, 1713, 2430], 'isotropic': [1070], 'mixing': [1071, 1115], 'period': [1072], '67': [1074], 'ms': [1075], 'acquired': [1077, 1118], '499.84': [1079], 'MHz,': [1080], 'spectral': [1082, 1123], 'widths': [1083, 1124], '6009.6': [1085], 'Hz': [1086, 1127], 'both': [1088, 1129, 1188, 2460], 'data': [1093, 1134, 1154, 1186, 3183], 'sizes': [1094, 1135], '2048': [1096], '256': [1098, 1139], 'complex': [1099, 1140], 'points': [1100, 1141], 'direct': [1103, 1144, 3116], 'indirect': [1105, 1146], 'dimensions,': [1106, 1147], 'respectively.': [1107, 1148], 'NOESY': [1110, 1279, 1712, 2429], '300-ms': [1114], '750.13': [1120], 'MHz': [1121], '8892.8': [1126], '1024': [1137], 'Fourier': [1150, 1206], 'transformations': [1151], 'performed': [1156, 1641], 'Felix': [1158], '95.0': [1159], '(Molecular': [1160], 'Simulations)': [1161], 'NMRPipe': [1163], '(7Delagalio': [1164], 'F.': [1165, 2331, 2448, 3053], 'Grzesiek': [1166], 'S.': [1167], 'Vuister': [1168], 'G.': [1169, 1171, 1246], 'Zhu': [1170, 1245], 'Pfeifer': [1172], 'Bax': [1174], '6:': [1180], '277-293PubMed': [1181], 'Time': [1184], 'apodized': [1191], 'squared': [1194], 'cosine': [1195], 'bell': [1196], 'prior': [1197], 'zero': [1199], 'filling': [1200], 'final': [1203, 1405, 1565, 2099, 2179], 'matrix': [1204], 'size,': [1205], 'transformation,': [1207], 'phase': [1209], 'correction.': [1210], 'initial': [1212, 1429], 'value': [1213], 'incremented': [1216], 'delay': [1217], 'set': [1219, 1532], 'manner': [1222], 'allowed': [1224], 'predictable': [1225], 'phasing': [1226], 'each': [1228, 2008, 2517], 'dimension': [1229], 'minimized': [1231, 1611, 2862], 'roll': [1232], 'offset': [1234], 'base': [1237], 'line': [1238], '(8Bax': [1239], 'Ikura': [1241], 'Kay': [1243], 'L.E.': [1244], 'Magn.': [1248], 'Reson.': [1249], '1991;': [1250], '91:': [1251], '174-178Google': [1252], '1H': [1255, 1645], 'referenced': [1258], 'internal': [1260], '2,2-dimethyl-2-silapentane-5-sulfonate.': [1261], 'Sequential': [1262], 'resonance': [1263, 1653], 'assignments': [1264, 1546, 1654, 1664, 1799], 'manually': [1270, 1448], '(9Wüthrich': [1281], 'Proteins': [1285], 'Nucleic': [1287], 'Acids.': [1288], 'John': [1289], 'Wiley': [1290], '&': [1291], 'Sons,': [1292], 'Inc.,': [1293], 'New': [1294], 'York1986Crossref': [1295], 'Subsequent': [1298], 'assignment': [1299], 'side': [1301, 2238, 2297, 2308, 2347, 2359, 2869, 2884, 3101, 3105, 3123], 'chains': [1302, 2298, 2348, 3102, 3124], 'NOEs': [1304, 1437, 1455, 1690, 2026], 'programs': [1312], 'Garant': [1313, 1489, 3192], '(10Bartels': [1314], 'C.': [1315, 1336, 1373, 2847, 2920], 'Billeter': [1316, 1339, 1589], 'Güntert': [1318, 1341], '1996;': [1325, 1596, 3056], '7:': [1326], '207-213Crossref': [1327], '(115)': [1330], 'Scholar)': [1332, 1386, 1603, 2573, 2930], 'XEASY': [1334], '(11Bartels': [1335], 'Xia': [1337], 'T.-H.': [1338], '5:': [1349, 3057], '1-10Crossref': [1350], '(1585)': [1353], 'Structures': [1356], 'calculated': [1358, 1562, 1584, 1882, 1970, 2124], 'approach': [1364], 'program': [1367], 'DYANA': [1368, 1527, 1613, 1925, 2047, 2176], '1.5': [1369], '(12Güntert': [1370], 'Mumenthaler': [1372], 'Mol.': [1377, 1594, 2564, 2586, 2655], '273:': [1380, 2589, 2658], '283-298Crossref': [1381], '(2537)': [1384], 'anneal.dya': [1389], 'macro': [1390], '4000': [1392], 'steps/structure': [1393], 'early': [1396], 'stages': [1397, 1520], 'refinement': [1399], '20,000': [1401], 'steps': [1402, 1410, 1616, 1955, 2077], 'rounds,': [1406], 'followed': [1407], '1000': [1409, 1615, 1954, 2076], 'conjugate': [1412, 1618, 1957, 2079], 'minimization.': [1414], 'Distance': [1415], 'constraint': [1416, 1481, 1835], 'upper': [1417, 1736], 'bounds': [1418], 'generated': [1420], 'CALIBA': [1423], 'function': [1424, 1476, 1576, 1840, 2112, 2181], 'DYANA.': [1426], 'For': [1427, 2007], 'round': [1430, 1462, 1495, 1566], 'calculations,': [1433], 'sequential': [1434], 'intraresidue': [1436], 'assigned': [1438, 1449, 1510, 1708], 'Garant,': [1440], 'small': [1445, 1542, 3002], 'number': [1446, 1543, 1676, 1688, 2011], 'additional': [1450, 1485, 1733, 2268], 'medium': [1451], 'long': [1453, 2024], 'range': [1454, 2025], 'used': [1457, 1478, 1649, 2000], 'input': [1459], 'restraints.': [1460], 'Each': [1461], 'started': [1463], '60': [1465, 1560], 'randomized': [1466], 'conformers,': [1467, 2094], 'lowest': [1474, 1574], 'target': [1475, 1575, 2111, 2180], 'analyze': [1480], 'violations': [1482, 1514, 1852, 1869, 2207], 'assign': [1484], '(in': [1488], 'XEASY)': [1491], 'following': [1494], 'refinement.': [1497], 'repeated': [1501], 'until': [1502], 'all': [1503, 1512, 1776, 1893, 1981, 2166, 2404, 2735, 2868], 'peaks': [1504], 'had': [1508], 'consistent': [1513, 2248], 'eliminated.': [1516], 'later': [1519], 'refinement,': [1522, 1568, 2102], 'GLOMSA': [1524], 'routine': [1525], 'applied': [1529], 'restraints': [1534], 'obtain': [1540, 1651], 'stereospecific': [1545], 'based': [1547], 'differences': [1549, 2468, 2624], 'intensities': [1552, 1808], 'diastereotopic': [1554], 'groups.': [1555], 'From': [1556], 'conformers': [1571, 2125, 2246], 'considered': [1578], 'analysis.': [1580], 'MOLMOL': [1586], '(13Koradi': [1587], 'R.': [1588, 3049], 'Graph.': [1595], '14:': [1597], '51-55Crossref': [1598], '(6454)': [1601], 'minimization': [1620, 1959, 2081, 2170], 'representative': [1625], 'analyses': [1629], 'deviation,': [1634], 'secondary': [1635, 1698], 'structure,': [1636, 1963, 2085, 2235], 'hydrogen': [1638, 2230, 2253, 2269], 'bonds': [1639, 2254, 2270], 'MOLMOL.': [1643], 'Two-dimensional': [1644], 'complete': [1652], 'chemically': [1656], '(PSP1).': [1661], '2Chemical': [1662], 'shift': [1663, 1684], 'deposited': [1669], 'BioMagResBank': [1672], 'Data': [1673], 'Base': [1674], '(accession': [1675], '4292).': [1677], 'Fig.2,': [1681], 'chemical': [1683], 'dispersion': [1685], 'large': [1687], 'observed': [1691, 2278], 'indicate': [1692], 'presence': [1694], 'tertiary': [1700, 2216], '699': [1705], 'cross-peaks': [1706], '333': [1718], 'nontrivial': [1719], 'produced': [1724, 2148], 'after': [1725], 'discarding': [1726], 'duplicate': [1727], 'structurally': [1729], 'redundant': [1730], 'NOEs.': [1731], 'Two': [1732], 'pairs': [1734], 'lower': [1738], 'bound': [1739], 'included': [1743], 'Sγ': [1746], 'Cβ': [1748], 'atoms': [1749, 1891, 1895, 1979, 1983, 2161], 'Cys7': [1751], 'Cys19': [1753], 'produce': [1755], 'normal': [1756], 'bond': [1758], 'geometry': [1759], '(2.0': [1760], '<': [1762, 1764, 1769, 2017, 2021], 'dS−S': [1763], '2.1': [1765], 'Å,': [1766], '3.72': [1767], 'dCβ−Cβ<': [1770], '3.99': [1771], 'Å).': [1772], 'summary': [1774, 2204], 'class': [1781, 3166], 'given': [1783, 2211], 'Table': [1785, 2213], 'I,': [1786], 'distribution': [1789], 'residue': [1793, 1996, 2974], 'Fig.3.': [1797], 'Stereospecific': [1798], 'Hα': [1811], 'protons': [1812, 1826], 'Gly17,': [1814], 'Hβprotons': [1816], 'Tyr11': [1818], 'Pro21,': [1820, 2354], 'Hγ': [1823], 'Hδ': [1825], 'Pro21.Table': [1828], 'IStructural': [1829], 'statistics': [1830], 'conformersNOE': [1834], 'totals': [1836], 'typeNumberLong92Medium73Short109Intraresidue59Disulfide4Total337Constraints/residue14.6DYANA': [1838], 'parameters〈TAD〉〈TAD〉rTarget': [1839], '(Å2)0.12': [1841], '±': [1842, 1849, 1854, 1858, 1866, 1871, 1875, 1905, 1907, 1912, 1914, 1917, 1919, 2114], '0.020.13Upper': [1843], 'limit': [1844], 'violationsNumber': [1845, 1862], '>': [1846, 1863], '0.1': [1847, 1864], 'Å4': [1848], '13Sum': [1850], '(Å)1.3': [1853], '0.11.2Maximum': [1855], 'violation': [1856, 1873], '(Å)0.19': [1857], '0.000.19Van': [1859], 'der': [1860], "Waals'": [1861], 'Å0': [1865], '00Sum': [1867], '(Å)0.2': [1870], '0.10.3Maximum': [1872], '(Å)0.05': [1874], '0.010.05Average': [1876], 'atomic': [1877, 2754], 'RMSD': [1878, 2151, 2186, 2755], '(Å)aAtomic': [1879], 'RMSDs': [1880, 1968, 2209], 'superposition': [1884, 1942, 1972, 2064], 'either': [1886, 1974, 3104], 'N,': [1888, 1976], 'Cα,': [1889, 1899, 1977], 'C′': [1890, 1978], 'nonhydrogen': [1894, 1982, 2167], '7–22.N,': [1898], 'C′All': [1900], 'nonhydrogen〈TAD〉': [1901], 'vs.〈': [1902, 1909], 'TAD': [1903, 1910, 1932, 1947, 1965, 2054, 2069, 2087], '〉0.18': [1904], '0.080.81': [1906], '0.20〈TAD〉': [1908], '〉min0.23': [1911], '0.100.94': [1913], '0.24〈TAD〉': [1915], 'pairwise0.27': [1916], '0.111.15': [1918], '0.30〈TAD〉,': [1920], '(TAD)': [1929, 2051], 'conformers;': [1930, 2052], '〈': [1931, 1946, 1964, 2053, 2068, 2086], '〉,': [1933, 2055], 'coordinates': [1936, 2058], 'least': [1940, 2062], 'squares': [1941, 2063], '7–22;': [1945, 2067], '〉min,': [1948, 2070], 'applying': [1953, 2075], '〉.a': [1966], 'Atomic': [1967], '7–22.': [1986], 'Open': [1987], 'table': [1988], 'new': [1991, 3165], 'tab': [1992], 'Figure': [1993, 2039], '3Distribution': [1994], 'determination': [2004], 'PSP1.': [2006, 2446, 2976], 'residue,': [2009, 2313], 'intraresidue,': [2013], 'sequential,': [2014], 'medium-range': [2015], '(1': [2016], ']‖i': [2018], '−': [2019], 'j‖': [2020], '4)': [2022], 'indicated': [2028], 'bars': [2030], 'white,': [2032], 'gray,white,': [2033], 'black,': [2035], 'respectively.View': [2036], 'Large': [2037], 'Image': [2038], 'ViewerDownload': [2040], '(PPT)': [2041], '〈TAD〉,': [2042], '〉.': [2088], 'resulted': [2096], 'stage': [2100], 'Fig.': [2106, 2381, 2858], '4.': [2107], 'low': [2109], '(0.12': [2113], '0.02': [2115], 'Å2)': [2116], 'indicates': [2117, 2433], 'good': [2118], 'agreement': [2119], 'experimental': [2128], 'constraints.': [2129], 'Superposition': [2130], 'ordered': [2134, 2289], '(7–22)': [2136], 'onto': [2140], 'corresponding': [2142], '0.84': [2163], 'atoms.': [2168, 2202], 'After': [2169], '0.13,': [2183], 'became': [2190], '0.23': [2191], '0.98': [2197], 'heavy': [2201], 'residual': [2206], 'I.': [2214], 'covalent': [2227], 'linkage,': [2229], 'bonding': [2231], 'β-hairpin': [2234, 2520], 'chain': [2239, 2309, 2897], 'packing.': [2240], 'pair': [2251], 'involving': [2255], 'amide': [2258], 'carbonyl': [2260], 'groups': [2261], 'Met12and': [2263], 'Lys20.': [2264, 2377], 'Evidence': [2265], '(Asp16': [2271], 'HN–Thr14': [2272], 'Oγ1,': [2273], 'Thr14': [2274], 'HN–Arg18': [2275], 'O)': [2276], 'subset': [2281, 2295], 'structures.': [2286, 2413], 'Within': [2287], 'portion': [2290], 'molecule,': [2293, 2887], 'forms': [2299], 'centered': [2305], 'around': [2306], 'Tyr11.': [2311], 'throughout': [2315], 'domains': [2320, 2477, 2677, 2961], 'phenylalanine': [2323], 'tyrosine': [2325, 2686], '(14Appella': [2326], 'E.': [2327, 3012], 'Weber': [2328], 'I.T.': [2329], 'Blasi': [2330], 'FEBS': [2332], 'Lett.': [2333], '1988;': [2334], '231:': [2335], '1-4Crossref': [2336], '(232)': [2339], 'contacts': [2344], 'Cys7,': [2350], 'Leu8,': [2351], 'Ala9,': [2352], 'Cys19,': [2353], 'Phe23.': [2356], 'opposite': [2358], 'largely': [2364], 'composed': [2365], 'exposed': [2367], 'charged': [2370, 2872, 3122], 'residues,': [2371], 'Arg13,': [2373, 2874], 'Asp16,': [2374, 2875], 'Arg18,': [2375, 2876], 'seen': [2379], '1,': [2382], 'Pseudaletia': [2389], 'separata,': [2390], 'sexta': [2397], 'differ': [2398], 'few': [2401], 'may': [2405, 2830, 3079], 'expected': [2407], 'adopt': [2409], 'same': [2411, 3128], 'not': [2422, 3080], 'reported,': [2424], 'preliminary': [2425], 'its': [2435, 2728], 'will': [2437, 2791], 'here': [2444], '3B.': [2447], 'Volkman,': [2449], 'unpublished': [2450, 2474], 'results.': [2451, 2475], 'Consistent': [2452], 'result': [2455], 'functional': [2457], 'assays': [2458], 'show': [2465], 'activity.': [2470], '4K.': [2471], 'Clark,': [2473], 'approximately': [2481], '40': [2482], 'length,': [2485], 'six': [2487], 'residues.': [2491], 'Three': [2492], 'loops,': [2493, 2532], 'designated': [2494], 'A,': [2495], 'B,': [2496], 'C,': [2498], 'pattern': [2503], 'bonding.': [2506], 'modules': [2508], 'alternatively': [2510], 'described': [2511], 'terms': [2513], 'subdomains,': [2516], 'disulfide-linked': [2531], 'smaller': [2535], 'third': [2541], 'C': [2545, 2640, 2700, 2730, 3093], 'loop.': [2546, 2766], '(hEGF)': [2554], '(15Hommel': [2555], 'U.': [2556], 'Harvey': [2557], 'T.S.': [2558], 'Driscol': [2559], 'P.C.': [2560], 'Campbell': [2561], 'I.C.': [2562], '227:': [2567], '271-282Crossref': [2568], '(119)': [2571], 'hTM5': [2576, 2643, 2743, 3006], '(16Sampoli-Benitez': [2577, 2646], 'B.A.': [2578, 2647], 'Hunter': [2579, 2648], 'M.J.': [2580, 2649], 'Meininger': [2581, 2650], 'D.P.': [2582, 2651], 'Komives': [2583, 2652, 3050], 'E.A.': [2584, 2653, 3051], '913-920Crossref': [2590, 2659], '(27)': [2593, 2662], 'spectroscopy,': [2602, 2994], 'share': [2603], 'general': [2605], 'structural': [2606, 3088], 'features': [2607], 'domains.': [2613], 'variability': [2615], 'illustrated': [2621], 'structures,': [2628], 'alternative': [2630], 'pairing': [2631], 'disulfides': [2636], 'longer': [2639], 'loop': [2641, 2701, 3094], 'than': [2644], 'hEGF': [2645], 'Sequence': [2665], 'representatives': [2671], 'limited': [2679], 'essential': [2682, 2966], 'cysteine,': [2683], 'glycine,': [2684], '(Fig.': [2693, 3108], '1),': [2694], 'extended': [2699], 'hTM5.': [2705], 'conformations': [2708], 'three': [2711, 2736], 'compared': [2714], 'Fig.5.': [2716], 'Except': [2717], 'displacement': [2720], 'β-turn': [2723], 'hEGF,': [2725], 'resulting': [2726], 'shorter': [2729], 'loop,': [2731], 'molecules': [2737], 'quite': [2739], 'similar.': [2740], 'align': [2744], 'remarkably': [2747], 'degree,': [2749], '∼1': [2757], '13': [2761], 'isolated': [2769], 'cell': [2778], 'surfaces,': [2782], 'defense.': [2788], 'Hence,': [2789], 'it': [2790, 2819], 'interest': [2794], 'determine': [2796], 'peptide.': [2802], 'Given': [2803], 'striking': [2805], 'modules,': [2818], 'tempting': [2821], 'speculate': [2823], 'ligand-receptor': [2826], 'analogous': [2832, 2973], 'those': [2834, 3074], 'array': [2837], 'domain-receptor': [2840], 'complexes': [2841, 3000], 'investigated': [2845], '(17McInnes': [2846, 2919], 'Sykes': [2848, 2921], 'B.D.': [2849, 2922], 'Biopolymers.': [2850, 2923], '43:': [2852, 2925], '339-366Crossref': [2853, 2926], '(65)': [2855, 2928], '6': [2859], 'chains.': [2870], 'Lys20': [2878], 'clearly': [2880, 3090], 'clustered': [2881], 'patch': [2890], 'surrounding': [2894], 'Tyr11side': [2896], 'located': [2899], 'opposing': [2902], 'side.': [2903], 'No': [2904], 'consensus': [2905], 'receptor-binding': [2906, 3161], 'site': [2907], 'yet': [2911], 'ligands,': [2915], 'intense': [2917], 'efforts': [2918], 'stemming': [2931], 'relevance': [2934], 'system': [2937], 'design': [2940], 'potential': [2942], 'drugs': [2943], 'treating': [2945], 'cancers.': [2947], 'studies': [2950], 'arginine': [2955], '(Arg41': [2962], 'hEGF)': [2964], 'binding.': [2968], 'Interestingly,': [2969], 'Arg18': [2970], 'Significant': [2977], 'effort': [2978], 'spent': [2981], 'investigating': [2982], 'details': [2984], 'thrombin': [2986, 3008], 'recognition': [2987], 'thrombomodulin,': [2989], 'alanine-scanning': [2991], 'mutagenesis,': [2992], 'x-ray': [2996], 'crystallography': [2997], 'fragments': [3004], '(18Nagashima': [3009], 'Lundh': [3011], 'Leonard': [3013], 'J.C.': [3014], 'Morser': [3015], 'Parkinson': [3017], 'J.F.': [3018], '1993;': [3022], '268:': [3023], '2888-2892Abstract': [3024], 'Scholar,': [3030, 3047], '19Mathews': [3031], 'I.I.': [3032], 'Padmanabhan': [3033], 'K.P.': [3034], 'Tulinsky': [3035], 'Sadler': [3037], 'J.E.': [3038], 'Biochemistry.': [3039], '1994;': [3040], '33:': [3041], '13547-13552Crossref': [3042], '(60)': [3045], '20Hrabal': [3048], 'Ni': [3052], 'Protein': [3054], 'Sci.': [3055], '195-203Crossref': [3058], '(20)': [3061], 'distinction': [3066], 'critical': [3069], 'proper': [3071], 'folding': [3072], 'directly': [3075], 'entirely': [3082], 'mutagenesis': [3085], 'alone,': [3086], 'interpretation': [3089], 'implicates': [3091], 'hTM5,': [3096], 'many': [3099], 'acidic': [3100, 3148], 'Cys421': [3107], '1).': [3109], 'None': [3110], 'correlation,': [3117], 'cluster': [3120], 'occurs': [3125], 'vicinity': [3129], 'absence': [3136], 'other': [3138, 3202], 'information': [3139], 'concentration': [3146], 'basic': [3150], 'obvious': [3154], 'starting': [3155], 'point': [3156], 'investigations': [3158], 'determinants': [3162], 'We': [3171, 3195], 'thank': [3172, 3197], 'Dr.': [3173, 3185, 3198], 'Milo': [3174], 'Westler': [3175], 'assistance': [3177], 'acquiring': [3179], 'processing': [3181], 'Dorothee': [3186], 'Kern': [3187], 'advice': [3189], 'XEASY.': [3194], 'also': [3196], 'Ed': [3199], 'Mooberry': [3200], 'members': [3203], 'National': [3206], 'Magnetic': [3207], 'Resonance': [3208], 'Facility': [3209], 'Madison': [3211], 'staff': [3212], 'gracious': [3214], 'help.': [3215]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2058617334', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-17T14:03:49.865287', 'created_date': '2016-06-24'}