Title: Facial clefts and congenital heart defects in children of parents with epilepsy: genetic and environmental etiologic factors
Abstract: Acta Neurologica ScandinavicaVolume 79, Issue 6 p. 433-458 Facial clefts and congenital heart defects in children of parents with epilepsy: genetic and environmental etiologic factors M. L. Friis, Corresponding Author M. L. Friis Department of Neurology, Odense University Hospital, DenmarkMogens Laue Friis M. D. Department of Neurology Odense University Hospital 29 Sdr. Boulevard DK-5000 Odense C DenmarkSearch for more papers by this author M. L. Friis, Corresponding Author M. L. Friis Department of Neurology, Odense University Hospital, DenmarkMogens Laue Friis M. D. Department of Neurology Odense University Hospital 29 Sdr. Boulevard DK-5000 Odense C DenmarkSearch for more papers by this author First published: June 1989 https://doi.org/10.1111/j.1600-0404.1989.tb03814.xCitations: 17AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract ABSTRACT— Increased prevalence of cleft lip with or without cleft palate (CL(P)), isolated cleft palate (CP), and congenital heart defects (CHD) in children of epileptic mothers have been ascribed to early fetal exposure to antiepileptic drugs (AED). However, common genetic factors responsible for both the malformations in question and the epileptic disorder might be of relevance for the increased rate of CL(P), CP, and CHD, rather than the influence of AED. The present review analyzes the literature on genetic and environmental etiologic factors (i.e. AED and epileptic seizures) that have been reported to increase the rate of CL(P), CP, and CHD in children of parents with epilepsy. Our data suggest that genetic factors are of minor importance for the etiology of facial clefts in offspring of epileptic patients. The rate of facial clefts was increased by a factor of 4.7 in children of AED treated mothers with epilepsy compared with the background population values. Children of fathers with epilepsy and sibs of epileptic patients had no more facial clefts than expected. The rate of CHD in children of mothers and fathers with epilepsy was comparable to population figures. 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