The p40 and p47 PX Domains of NADPH Oxidase Target Cell Membranes via Direct and Indirect Recruitment by Phosphoinositides

Name: Work Video:
Duration: 3 min 30 s
Yong Zhan; Joseph V. Virbasius; Xi Song; Darcy P. Pomerleau; G. Wayne Zhou
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'domains': [16, 191, 229, 404, 749, 1184, 1741, 2013, 2258, 3290, 4632, 6001], 'can': [17, 140, 192, 230, 353, 405, 1009, 1824, 1968, 2017, 5479, 5561], 'localize': [18, 231, 1825, 1969, 3458, 4393], 'endosomes': [20, 46, 233, 259, 1015, 1827, 3652], 'in': [21, 41, 47, 62, 86, 137, 165, 234, 254, 260, 275, 299, 350, 378, 487, 500, 510, 522, 730, 738, 1016, 1338, 1365, 1370, 1561, 1711, 1742, 1828, 2014, 2292, 2421, 2431, 2445, 2467, 2512, 2579, 2586, 2593, 2614, 2622, 2651, 2790, 2793, 2801, 2816, 2840, 2847, 2864, 2901, 3000, 3015, 3038, 3042, 3067, 3084, 3197, 3201, 3287, 3388, 3429, 3464, 3502, 3511, 3623, 3626, 3631, 3653, 3777, 3781, 3831, 3892, 3908, 3960, 3975, 3982, 4049, 4111, 4128, 4197, 4483, 4492, 4518, 4560, 4585, 4633, 4759, 4783, 4821, 4858, 5003, 5042, 5181, 5204, 5222, 5251, 5273, 5305, 5339, 5427, 5502, 5574, 5845, 5872, 5919, 5931, 5951, 5985, 6002, 6009, 6016, 6103], 'vivo.': [22, 235], 'Here': [23, 236, 1834], 'we': [24, 74, 96, 237, 287, 309, 1835, 1917, 3030, 3295, 4021, 4283, 4357, 4500, 5163, 5295, 5402, 5994], 'show': [25, 97, 238, 310, 1962, 4853, 5469], 'data': [26, 149, 239, 362, 1837, 1932, 2008, 4950, 4956, 5468], 'support': [28, 241, 1839, 4725, 6080], 'the': [29, 32, 77, 99, 111, 118, 145, 152, 159, 166, 169, 182, 186, 207, 242, 245, 290, 312, 324, 331, 358, 365, 372, 379, 382, 395, 399, 420, 429, 433, 488, 491, 760, 1214, 1250, 1290, 1339, 1373, 1395, 1398, 1407, 1414, 1425, 1433, 1438, 1451, 1456, 1463, 1474, 1477, 1551, 1562, 1646, 1649, 1699, 1702, 1712, 1730, 1739, 1820, 1840, 1844, 1920, 1924, 1930, 1964, 1971, 1982, 1999, 2003, 2011, 2037, 2093, 2101, 2128, 2140, 2154, 2172, 2188, 2193, 2197, 2204, 2212, 2220, 2231, 2240, 2255, 2344, 2351, 2408, 2508, 2535, 2652, 2665, 2679, 2706, 2714, 2719, 2736, 2748, 2841, 2848, 2855, 2860, 2960, 2967, 2971, 2976, 3001, 3016, 3032, 3039, 3043, 3085, 3101, 3105, 3115, 3191, 3222, 3288, 3297, 3313, 3318, 3328, 3367, 3389, 3401, 3405, 3418, 3422, 3435, 3445, 3465, 3477, 3494, 3585, 3588, 3610, 3616, 3640, 3643, 3669, 3692, 3710, 3721, 3754, 3772, 3778, 3782, 3794, 3829, 3847, 3852, 3858, 3870, 3877, 3886, 3909, 3918, 3962, 3966, 3976, 4013, 4016, 4023, 4027, 4036, 4041, 4050, 4058, 4094, 4101, 4123, 4129, 4137, 4169, 4286, 4293, 4299, 4326, 4333, 4340, 4344, 4351, 4359, 4373, 4389, 4395, 4407, 4416, 4421, 4425, 4428, 4466, 4470, 4477, 4480, 4484, 4493, 4503, 4508, 4529, 4534, 4544, 4552, 4561, 4567, 4581, 4586, 4592, 4595, 4601, 4610, 4614, 4618, 4630, 4648, 4726, 4730, 4738, 4750, 4766, 4793, 4799, 4813, 4828, 4862, 4898, 4954, 4959, 4994, 5033, 5112, 5116, 5166, 5182, 5212, 5220, 5223, 5249, 5252, 5266, 5274, 5289, 5299, 5313, 5319, 5384, 5393, 5398, 5423, 5447, 5471, 5475, 5481, 5485, 5491, 5503, 5563, 5570, 5575, 5730, 5795, 5839, 5856, 5873, 5883, 5899, 5903, 5908, 5922, 5928, 5949, 5952, 5974, 5989, 5998, 6030, 6048, 6053, 6066, 6104], 'conclusion': [30, 243, 1842], 'that': [31, 76, 102, 135, 151, 244, 289, 315, 348, 364, 484, 1738, 1838, 1919, 1963, 1981, 2010, 2574, 2987, 3050, 3104, 3366, 3493, 3642, 3715, 3761, 3857, 4406, 4435, 4465, 4543, 4737, 4765, 4812, 4897, 4957, 5032, 5050, 5301, 5312, 5474, 5802, 5853, 5964, 5997], 'p40phox': [33, 187, 246, 400, 430, 489, 1554, 1637, 1708, 1743, 1821, 1845, 2094, 2144, 2189, 2856, 2972, 3106, 3292, 3406, 3424, 3495, 3644, 4634, 4731, 4739, 4767, 6031], 'binds': [36, 82, 249, 295, 3498, 4742, 4902, 4963], 'phosphatidylinositol': [38, 60, 93, 210, 251, 273, 306, 423, 437, 441, 443, 445, 447, 450, 453, 456, 459, 5800], '3-phosphate': [39, 61, 252, 274, 444], 'specifically': [40, 253, 1004, 4745], 'vitro': [42, 87, 255, 300, 5428, 6010], 'localizes': [44, 257, 5926], 'intact': [48, 261, 3512, 4784], 'cells.': [49, 262, 3451, 4115, 4785, 5412], 'In': [50, 263, 1177, 1394, 1420, 1818, 3322, 3797, 4116, 4298, 4424, 4824, 4891, 5157, 5389, 5413, 5992], 'addition,': [51, 264, 1178, 1819], 'its': [52, 132, 265, 345, 1298, 2869, 3025, 3225, 3306, 3371, 3411, 3657, 3676, 4109, 4379, 4438, 4756, 5023, 5343, 5895, 5959, 5986, 6036], 'Y59A/L65Q': [53, 266, 2184, 4751, 4794], 'mutant,': [54, 267], 'which': [55, 268, 3619, 4364, 5013, 5174, 5205, 5444], 'decreased': [57, 270], 'affinity': [58, 91, 271, 304, 1192, 2871, 2907, 2911, 3027, 3308, 3345, 3678, 3728, 3735, 3833, 4905, 5291, 5334], 'for': [59, 92, 98, 272, 305, 311, 953, 1473, 1486, 1645, 2036, 2281, 2407, 2449, 2454, 2492, 2636, 2669, 2761, 2773, 2830, 2872, 2908, 2912, 3028, 3091, 3309, 3679, 3729, 3736, 4617, 4780, 4792, 5100, 5228, 5286, 5331, 5335, 5470, 5878, 5894, 6079, 6091, 6107], 'vitro,': [63, 276, 3624, 4371], 'fails': [64, 277], 'target': [66, 142, 193, 279, 355, 406, 759, 1011, 2018, 4647, 5480, 6012], 'EGFP-p40-PX': [67, 280, 3446, 3453, 3596, 3600], 'endosomes.': [69, 282], 'However,': [70, 283, 1213, 1694, 1991, 3828, 3866, 4141, 4613, 4857, 4993, 5230, 5430, 5898], 'unlike': [71, 284], 'published': [72, 285, 1931, 2375, 3116, 4727, 4955], 'results,': [73, 286], 'find': [75, 288, 1918, 4811], 'p47phox': [78, 112, 155, 172, 189, 291, 325, 368, 385, 402, 434, 492, 1251, 1294, 1470, 1710, 1745, 1925, 1965, 2004, 2102, 2198, 3671, 3859, 3977, 4028, 4095, 4345, 4417, 4426, 4553, 4636, 4814, 4829, 4863, 4899, 4960, 5034, 5317, 5399, 5476, 5857, 5923, 5975, 6049, 6070], 'weakly': [81, 294], 'many': [84, 297], 'phosphoinositides': [85, 298, 757, 1749, 2873, 3681, 3711, 3836, 3920, 4643, 5088, 5221, 6008, 6041], 'showing': [88, 301], 'slightly': [89, 302], 'higher': [90, 303, 3842, 5279], '3,4,5-trisphosphate.': [94, 307], 'Moreover,': [95, 308, 1289, 5948], 'first': [100, 313, 5472], 'time': [101, 314, 5473], 'upon': [103, 316, 1974, 3482, 4142], 'insulin-like': [104, 317, 461], 'growth': [105, 318, 462, 735, 4185, 5723], 'factor-1': [106, 319, 463], 'stimulation': [107, 320, 4143, 5850], 'of': [108, 154, 171, 209, 321, 367, 384, 422, 494, 732, 998, 1181, 1217, 1293, 1326, 1343, 1372, 1400, 1428, 1450, 1455, 1476, 1553, 1564, 1648, 1701, 1714, 1923, 1977, 2002, 2130, 2143, 2187, 2196, 2224, 2434, 2470, 2487, 2515, 2521, 2534, 2589, 2678, 2697, 2970, 2990, 3010, 3034, 3056, 3063, 3075, 3082, 3097, 3100, 3194, 3224, 3291, 3302, 3327, 3382, 3396, 3404, 3421, 3438, 3471, 3479, 3587, 3615, 3649, 3695, 3709, 3716, 3756, 3767, 3775, 3788, 3805, 3819, 3872, 3880, 3901, 3915, 4015, 4026, 4152, 4163, 4171, 4288, 4301, 4328, 4343, 4362, 4469, 4512, 4570, 4574, 4622, 4835, 4837, 4873, 5008, 5093, 5115, 5168, 5188, 5211, 5234, 5288, 5292, 5316, 5380, 5386, 5397, 5454, 5505, 5565, 5572, 5732, 5797, 5838, 5855, 5862, 5886, 5902, 5910, 5944, 6029, 6069], 'COS': [109, 322, 1978, 2741, 3450, 4104, 4519, 5411, 5846, 6017], 'cells,': [110, 323, 4105, 4118, 5415], 'is': [115, 125, 175, 328, 338, 388, 476, 485, 1471, 1555, 1696, 1985, 1995, 3647, 4330, 4348, 4411, 4625, 4735, 4770, 5052, 5282, 5310, 5488, 5725, 5891, 5941], 'localized': [116, 329, 1405, 5419], 'plasma': [119, 146, 160, 183, 332, 359, 373, 396, 1972, 4138, 4396, 4422, 4494, 4535, 4562, 5441, 5482, 5576, 5929, 5990, 6054], 'membrane,': [120, 333, 4563, 5483], 'this': [122, 335, 1992, 2580, 4498, 5161, 5340, 5463, 5809], 'subcellular': [123, 194, 336, 407, 766, 2019, 4788, 6014], 'localization': [124, 337, 3608, 4110, 4287, 4789], 'dependent': [126, 339, 1997, 5489], 'on': [127, 340, 1998, 3656, 3869, 4018, 4385, 4521, 5022, 5490, 5848], 'PI': [128, 341, 515, 1219, 1988, 2030, 3589, 4194, 4294, 4334, 4807, 5171, 5191, 5206, 5262, 5387, 5492, 5495, 5566, 5879, 5945, 6024], '3-kinase': [129, 211, 342, 424, 438, 1220, 1989, 2031, 3590, 4195, 4295, 4335, 4808, 5493, 5496, 5567, 5880, 5946], 'activity.': [130, 212, 343, 425, 746, 1990, 2032, 4336, 5494, 5881], 'Unexpectedly,': [131, 344, 4524], 'R42Q': [133, 346, 2194, 2237, 4024, 4360], 'mutant': [134, 347, 2186, 2195, 2218, 2223, 2238, 3300, 3329, 3369, 3403, 4025, 4361, 4374, 4390, 4506, 4511, 4753, 4796, 5901], 'loses': [136, 349, 5916], 'vitrophosphoinositide-binding': [138, 351], 'ability': [139, 352, 2001, 3226, 3372, 3413, 3420, 3658, 4410, 4530, 5320, 5426, 5885, 5909, 5918], 'still': [141, 354, 4392, 4527, 5246, 5906], 'EGFP-p47-PX': [143, 356, 2167, 2234, 2236, 4102, 4119, 4146, 4303, 4329, 4513, 5416, 5437, 5455, 5841], 'membrane.': [147, 184, 360, 397, 4423, 4495, 5991, 6055], 'Our': [148, 361, 2007, 4723, 4947, 5467], 'suggest': [150, 363, 2009, 3103, 4542, 4958, 5852], 'translocation': [153, 366, 1563, 4380, 4517, 5854, 5987, 6068], 'membrane': [161, 374, 1408, 1434, 1464, 1973, 1983, 2608, 2643, 2666, 2685, 2707, 2886, 2926, 4139, 4153, 4164, 4308, 4397, 4467, 4536, 4582, 4602, 4653, 5442, 5448, 5577, 5717, 5843, 5863, 5896, 5911, 5930, 5960, 6067], 'does': [162, 375, 5037], 'involve': [163, 376], '3′-phosphoinositide(s)': [164, 377], 'process,': [167, 380], 'but': [168, 381, 2918, 3896, 4849, 5281], 'phosphoinositide-binding': [170, 383, 1921, 2000, 2968, 4819, 5290, 5884, 5917], 'not': [176, 389, 1996, 3883, 4412, 4626, 4852, 5038, 5244, 5418, 6043], 'sufficient': [177, 390, 4413, 6044], 'recruit': [179, 392, 4415, 6047], 'it': [180, 393, 3088, 3433, 3897, 4033, 4354, 4850, 5309, 5328, 5404, 5409, 5914, 5940], 'Therefore,': [185, 398, 3400, 4325], 'membranes': [195, 408, 2020, 2074, 2601, 3501, 4782], 'via': [196, 409, 2021, 6019], 'direct': [197, 410, 2022], 'or': [198, 411, 2023, 2235, 3394, 4113, 4155, 4797, 5192, 5207, 5559, 5722, 5870], 'indirect': [199, 412, 2024], 'recruitment': [200, 413, 2025], 'by': [201, 414, 1830, 2026, 2029, 2153, 2171, 2229, 2247, 2290, 2327, 2526, 2723, 2747, 3221, 3431, 3682, 4168, 4177, 4332, 4350, 4476, 4591, 5124, 5452, 5720, 6023], 'while': [203, 416, 1249, 1469, 2734, 3006, 4749, 5258, 5342, 5794, 5913, 6040], 'both': [204, 417, 1327, 2522, 3312, 3900, 3961, 4035, 4502, 4525, 5176], 'are': [205, 418, 1403, 1720, 3285, 3637, 4160, 4577, 4951, 5175, 5383, 5865, 6042, 6060], 'under': [206, 419, 5867], 'control': [208, 421], 'phosphatidylcholine': [439], 'phosphatidylethanolamine': [440], 'phosphatidylserine': [442], '4-phosphate': [446], '5-phosphate': [448], '4)P2,': [449], '3,4-bisphosphate': [451], '5)P2,': [452, 455], '3,5-bisphosphate': [454], '4,5-bisphosphate': [457], '4,5)P3,': [458], '3,4,5-trisphosphate': [460], 'enhanced': [464, 2724, 3439], 'green': [465, 2136, 3440], 'fluorescent': [466, 2137, 3441], 'protein': [467, 2138, 2346, 2489, 2716, 2862, 2881, 2893, 2997, 3012, 3036, 3385, 3442, 3454, 3807, 3821, 4491, 5236], 'Src': [468], '3': [470, 2762], '(PX)1': [474], 'a': [477, 723, 1334, 1350, 1460, 1559, 1726, 2111, 2422, 2446, 2587, 2694, 2875, 2885, 3349, 3627, 3904, 3971, 4432, 4488, 4806, 4893, 5053, 5498, 5799, 5932, 5969, 5983], 'module': [478, 726], 'with': [479, 727, 755, 1006, 1190, 1222, 1260, 1383, 1437, 1729, 2076, 2127, 2276, 2333, 2353, 2411, 2541, 2609, 2655, 2662, 2675, 2693, 2710, 2730, 2776, 2806, 2818, 2833, 2884, 2888, 2896, 2928, 3004, 3019, 3048, 3070, 3079, 3111, 3114, 3476, 3485, 3595, 3606, 3639, 3714, 3903, 3984, 4131, 4136, 4144, 4179, 4193, 4315, 4383, 4400, 4437, 4609, 4746, 4774, 4804, 4870, 4903, 4953, 5016, 5255, 5323, 5405, 5435, 5456, 5460, 5729, 6057], 'about': [480, 1698, 3803, 4729, 5004], '130': [481], 'amino': [482, 3283], 'acids': [483, 2098, 2106, 2165, 2181, 3284], 'present': [486, 3037], 'subunit': [493, 1458], 'NADPH': [495, 744, 1323, 1401, 1429, 1479, 1715, 2015, 4575, 4623, 5506, 6003], 'oxidase': [496, 745, 1402, 1430, 1480, 2016, 4576, 4624, 5507, 6004], 'as': [497, 499, 505, 1483, 2045, 2239, 2501, 2552, 2688, 2739, 2859, 3071, 3073, 3602, 4125, 4127, 4166, 5097, 5450], 'well': [498, 4126], 'other': [502, 1346, 2922, 3020, 3826, 4546, 4558, 5934, 5967, 5980], 'proteins': [503, 521, 763, 1013, 2576, 3699, 6059], 'such': [504], 'Mvp1p,': [506], 'Vps5p,': [507], 'Grd19p': [509], 'yeast,': [511], 'phospholipase': [513], 'D1,': [514], '3-kinase,': [516], 'CISK,': [517, 1001], 'sorting': [519], 'nexin': [520], 'mammalian': [523, 3513], 'cells': [524, 1348, 1979, 2742, 2755, 2770, 2798, 2866, 3484, 3514, 4520, 4801, 5432, 5847, 6018], '(1Ponting': [525], 'C.P.': [526], 'Protein': [527], 'Sci.': [528, 709, 941, 1165, 5749], '1996;': [529, 1537, 5708, 5753], '5:': [530], '2353-2357Crossref': [531], 'PubMed': [532, 556, 577, 618, 645, 670, 689, 716, 788, 809, 850, 877, 902, 921, 948, 967, 988, 1037, 1058, 1099, 1126, 1145, 1172, 1208, 1244, 1284, 1318, 1361, 1497, 1519, 1545, 1583, 1617, 1632, 1689, 1786, 1813, 1884, 1911, 1955, 2068, 2400, 2568, 3154, 3181, 3215, 3250, 3275, 3529, 3555, 3579, 3948, 4006, 4231, 4255, 4278, 4458, 4691, 4718, 4942, 4988, 5078, 5152, 5374, 5533, 5553, 5596, 5623, 5650, 5676, 5695, 5711, 5756, 5789, 5830], 'Scopus': [533, 557, 578, 619, 646, 671, 690, 717, 789, 810, 851, 878, 903, 922, 949, 968, 989, 1038, 1059, 1100, 1127, 1146, 1173, 1209, 1245, 1285, 1319, 1498, 1520, 1546, 1584, 1618, 1633, 1690, 1787, 1814, 1885, 1912, 1956, 2069, 2401, 2569, 3155, 3182, 3216, 3251, 3276, 3530, 3556, 3580, 3949, 4007, 4232, 4256, 4279, 4459, 4692, 4719, 4943, 4989, 5079, 5153, 5375, 5534, 5554, 5597, 5624, 5651, 5677, 5696, 5712, 5757, 5790, 5831], '(266)': [534], 'Google': [535, 559, 580, 621, 648, 673, 692, 719, 791, 812, 853, 880, 905, 924, 951, 970, 991, 1040, 1061, 1102, 1129, 1148, 1175, 1211, 1247, 1287, 1321, 1362, 1500, 1522, 1548, 1586, 1620, 1635, 1692, 1789, 1816, 1887, 1914, 1958, 2071, 2403, 2571, 3157, 3184, 3218, 3253, 3278, 3532, 3558, 3582, 3951, 4009, 4234, 4258, 4281, 4461, 4694, 4721, 4945, 4991, 5081, 5155, 5377, 5536, 5556, 5599, 5626, 5653, 5679, 5698, 5714, 5759, 5792, 5833], 'Scholar,': [536, 560, 581, 622, 649, 674, 693, 792, 813, 854, 881, 906, 925, 1041, 1062, 1103, 1130, 1149, 1501, 1523, 1587, 1621, 1790, 1888, 3158, 3254, 3533, 3559, 4235, 4259, 4695, 5537, 5600, 5627, 5654, 5680, 5699, 5760], '2Cheever': [537], 'M.L.': [538, 770, 1019, 3232], 'Sato': [539, 771, 1020, 3233], 'T.K.': [540, 772, 1021, 3204, 3234], 'de': [541, 773, 1022, 3235], 'Beer': [542, 774, 1023, 3236], 'T.': [543, 545, 632, 775, 777, 864, 1024, 1026, 1113, 1271, 1305, 1307, 1800, 1898, 1942, 3168, 3206, 3237, 3239, 3935, 4267, 4445, 4447, 4705, 4929, 4975, 5060, 5361, 5539, 5774, 5819], 'Kutateladze': [544, 776, 1025, 3238], 'Emr': [546, 778, 1027, 3207, 3240, 3517], 'S.D.': [547, 779, 1028, 3208, 3241, 3518], 'Overduin': [548, 780, 1029, 3242], 'M.': [549, 781, 1030, 1602, 3243, 3539, 4221, 4225, 4263, 5066, 5134, 5547, 5772, 5815], 'Nat.': [550, 571, 612, 639, 707, 782, 803, 844, 871, 939, 961, 1031, 1052, 1093, 1120, 1163, 1278, 1312, 1492, 1683, 1780, 1807, 1878, 1905, 1949, 3148, 3175, 3244, 3942, 4452, 4685, 4712, 4936, 4982, 5368], 'Cell': [551, 572, 613, 640, 684, 783, 804, 845, 872, 916, 962, 1032, 1053, 1094, 1121, 1140, 1279, 1684, 1781, 1808, 1879, 1906, 1950, 3149, 3176, 3245, 3943, 4686, 4713, 4937, 4983, 5369], 'Biol.': [552, 573, 614, 641, 685, 784, 805, 846, 873, 917, 963, 1033, 1054, 1095, 1122, 1141, 1198, 1280, 1314, 1509, 1535, 1613, 1685, 1782, 1809, 1880, 1907, 1951, 3150, 3177, 3211, 3246, 3569, 3944, 4245, 4274, 4454, 4687, 4714, 4938, 4984, 5068, 5142, 5370, 5521, 5592, 5613, 5666, 5780, 5826], '2001;': [553, 574, 615, 642, 667, 686, 713, 785, 806, 847, 874, 899, 918, 945, 964, 980, 1034, 1055, 1096, 1123, 1142, 1169, 1200, 1241, 1281, 1315, 1494, 1686, 1783, 1810, 1881, 1908, 1952, 2065, 2397, 3151, 3178, 3247, 3272, 3945, 4003, 4455, 4688, 4715, 4939, 4985, 5070, 5371, 5692], '3:': [554, 575, 616, 643, 786, 807, 848, 875, 965, 1035, 1056, 1097, 1124, 1282, 1687, 1784, 1811, 1882, 1909, 1953, 3152, 3179, 3248, 3946, 4689, 4716, 4940, 4986, 5372], '613-618Crossref': [555, 787, 1036, 3249], '(316)': [558, 790, 1039, 3252], '3Xu': [561, 793, 1042], 'Y.': [562, 701, 794, 933, 1043, 1157, 4209, 5545, 5602, 5705, 6099], 'Hortsman': [563, 795, 1044], 'H.': [564, 591, 626, 630, 796, 823, 858, 862, 960, 1045, 1072, 1107, 1111, 1265, 1269, 1303, 1309, 1662, 1759, 1794, 1798, 1857, 1892, 1896, 1936, 1940, 3127, 3162, 3166, 3549, 3567, 3929, 3933, 4207, 4211, 4443, 4449, 4664, 4699, 4703, 4923, 4927, 4969, 4973, 5355, 5359, 5543, 5629], 'Seet': [565, 797, 1046], 'L.': [566, 798, 1047, 5776, 5778], 'Wong': [567, 799, 1048], 'S.H.': [568, 800, 1049], 'Hong': [569, 801, 1050], 'W.': [570, 653, 802, 885, 1051, 1227, 2051, 2383, 3258], '658-666Crossref': [576, 808, 1057], '(240)': [579, 811, 1060], '4Ellson': [582, 814, 1063], 'C.D.': [583, 815, 1064, 1654, 1751, 1849, 3119, 4656], 'Gobert-Grosse': [584, 816, 1065, 1655, 1752, 1850, 3120, 4657], 'S.': [585, 711, 817, 943, 1066, 1167, 1567, 1596, 1606, 1623, 1656, 1753, 1851, 2556, 3121, 4658, 5608, 5660, 5751, 5762], 'Anderson': [586, 818, 1067, 1657, 1754, 1852, 3122, 4659], 'K.E.': [587, 819, 1068, 1658, 1755, 1853, 3123, 4660], 'Davidson': [588, 820, 1069, 1659, 1756, 1854, 3124, 4661], 'K.': [589, 821, 1070, 1625, 1660, 1757, 1855, 3125, 4201, 4203, 4205, 4662, 5062, 5064, 5585, 5768, 5770], 'Erdjument-Bromage': [590, 822, 1071, 1661, 1758, 1856, 3126, 4663], 'Tempst': [592, 824, 1073, 1663, 1760, 1858, 3128, 4665], 'P.': [593, 825, 1074, 1664, 1761, 1859, 3129, 4261, 4666, 5589, 5684, 5764, 5813, 6077], 'Thuring': [594, 826, 1075, 1665, 1762, 1860, 3130, 4667], 'J.W.': [595, 827, 1076, 1194, 1666, 1763, 1861, 3131, 4668], 'Cooper': [596, 828, 1077, 1667, 1764, 1862, 3132, 4669, 5638], 'M.A.': [597, 829, 1078, 1196, 1574, 1610, 1668, 1765, 1863, 3133, 4670, 5140, 5579], 'Lim': [598, 830, 1079, 1669, 1766, 1864, 3134, 4671], 'Z.-Y.': [599, 831, 1080, 1670, 1767, 1865, 3135, 4672], 'Holmes': [600, 832, 1081, 1671, 1768, 1866, 3136, 4673], 'A.B.': [601, 833, 1082, 1672, 1769, 1867, 3137, 4674], 'Gaffney': [602, 834, 1083, 1673, 1770, 1868, 3138, 4675], 'P.R.J.': [603, 835, 1084, 1674, 1771, 1869, 3139, 4676], 'Coadwell': [604, 836, 1085, 1675, 1772, 1870, 3140, 4677], 'J.': [605, 676, 683, 837, 908, 915, 1086, 1132, 1139, 1197, 1508, 1534, 1572, 1578, 1590, 1608, 1611, 1626, 1676, 1773, 1871, 2564, 3141, 3545, 3551, 3568, 3991, 4227, 4244, 4678, 5067, 5141, 5511, 5520, 5612, 5665], 'Chilvers': [606, 838, 1087, 1677, 1774, 1872, 3142, 4679], 'E.R.': [607, 839, 1088, 1678, 1775, 1873, 3143, 4680], 'Hawkins': [608, 840, 1089, 1679, 1776, 1874, 3144, 4681, 5763], 'P.T.': [609, 841, 1090, 1680, 1777, 1875, 3145, 4682], 'Stephens': [610, 842, 1091, 1681, 1778, 1876, 3146, 4683, 5777], 'L.R.': [611, 843, 1092, 1682, 1779, 1877, 3147, 4684], '679-682Crossref': [617, 849, 1098, 1688, 1785, 1883, 3153, 4690], '(362)': [620, 852, 1101, 1691, 1788, 1886, 3156, 4693], '5Kanai': [623, 855, 1104, 1791, 1889, 3159, 4696], 'F.': [624, 856, 1105, 1263, 1576, 1604, 1792, 1890, 1934, 3160, 3927, 4219, 4697, 4921, 4967, 5353, 5766], 'Liu': [625, 677, 857, 909, 1106, 1133, 1264, 1793, 1891, 1935, 3161, 3928, 4698, 4922, 4968, 5354], 'Field': [627, 859, 1108, 1266, 1795, 1893, 1937, 3163, 3930, 4700, 4924, 4970, 5356], 'S.J.': [628, 860, 1109, 1267, 1796, 1894, 1938, 3164, 3931, 4701, 4925, 4971, 5136, 5357], 'Akbary': [629, 861, 1110, 1268, 1797, 1895, 1939, 3165, 3932, 4702, 4926, 4972, 5358], 'Matsuo': [631, 863, 1112, 1270, 1799, 1897, 1941, 3167, 3934, 4704, 4928, 4974, 5360], 'Brown': [633, 865, 1114, 1272, 1801, 1899, 1943, 3169, 3936, 4706, 4930, 4976, 5362], 'G.E.': [634, 866, 1115, 1273, 1802, 1900, 1944, 3170, 3937, 4707, 4931, 4977, 5363], 'Cantley': [635, 867, 1116, 1274, 1803, 1901, 1945, 3171, 3938, 4708, 4932, 4978, 5364], 'L.C.': [636, 868, 1117, 1275, 1804, 1902, 1946, 3172, 3939, 4709, 4933, 4979, 5365], 'Yaffe': [637, 869, 1118, 1276, 1805, 1903, 1947, 3173, 3940, 4710, 4934, 4980, 5366], 'M.B.': [638, 870, 1119, 1277, 1806, 1904, 1948, 3174, 3941, 4711, 4935, 4981, 5367], '675-678Crossref': [644, 876, 1125, 1283, 1812, 1910, 1954, 3180, 3947, 4717, 4941, 4987, 5373], '(501)': [647, 879, 1128, 1286, 1815, 1913, 1957, 3183, 3950, 4720, 4944, 4990, 5376], '6Song': [650, 882, 3255], 'X.': [651, 659, 697, 883, 891, 929, 1153, 1225, 1233, 2049, 2057, 2381, 2389, 3256, 3264, 5581], 'Xu': [652, 884, 1226, 2050, 2382, 3257], 'Zhang': [654, 886, 1228, 2052, 2384, 3259, 6086], 'A.': [655, 712, 887, 944, 958, 1168, 1229, 2053, 2385, 3260, 4213, 4215, 5132, 5517, 5682, 5690, 5701, 5741, 5752], 'Huang': [656, 888, 1230, 2054, 2386, 3261], 'G.': [657, 680, 889, 912, 1136, 1231, 2055, 2387, 3262], 'Liang': [658, 890, 1232, 2056, 2388, 3263], 'Virbasius': [660, 892, 1234, 2058, 2390, 3265], 'J.V.': [661, 695, 893, 927, 1151, 1235, 2059, 2391, 3266], 'Czech': [662, 704, 894, 936, 1160, 1236, 2060, 2392, 3267, 6078], 'M.P.': [663, 705, 895, 937, 1161, 1237, 2061, 2393, 3268], 'Zhou': [664, 702, 896, 934, 1158, 1238, 2062, 2394, 3269, 6105], 'G.W.': [665, 703, 897, 935, 1159, 1239, 2063, 2395, 3270], 'Biochemistry.': [666, 898, 1240, 2064, 2396, 3271], '40:': [668, 900, 1242, 2066, 2398, 3273], '8940-8944Crossref': [669, 901, 1243, 2067, 2399, 3274], '(107)': [672, 904, 1246, 1547, 2070, 2402, 3277], '7Xu': [675, 907, 1131], 'D.': [678, 910, 1134, 1311, 3989, 4451, 5611, 5703], 'Gill': [679, 911, 1135], 'Songyang': [681, 913, 1137], 'Z.': [682, 914, 1138], '154:': [687, 919, 1143], '699-705Crossref': [688, 920, 1144], '(95)': [691, 923, 1147], '8Virbasius': [694, 926, 1150], 'Song': [696, 928, 1152], 'Pomerleau': [698, 930, 1154], 'D.P.': [699, 931, 1155], 'Zhan': [700, 932, 1156], 'Proc.': [706, 938, 1162, 5746], 'Acad.': [708, 940, 1164, 5748], 'U.': [710, 942, 1166, 5750], '98:': [714, 946, 1170], '12908-12913Crossref': [715, 947, 1171], '(76)': [718, 950, 1174, 4280, 5832], 'Scholar).': [720, 992, 1176, 1212, 1288, 1322, 1363, 1636, 1693, 1817, 1915, 1959, 2072, 3185, 3279, 3583, 3952, 4010, 4462, 4722, 4946, 4992, 5156, 5378, 5557, 5715, 5834], 'It': [721, 4734, 5030, 5046], 'represents': [722], 'widely': [724], 'distributed': [725], 'potential': [728, 5394], 'functions': [729, 1700], 'regulation': [731, 5869], 'vesicular': [733, 3593], 'trafficking,': [734], 'factor-receptor': [736], 'degradation': [737], 'lysosomes,': [739], 'signal': [740], 'transduction': [741], 'mechanisms,': [742], 'Recently,': [747, 1733, 3970, 4629], 'have': [750, 1736, 4762, 5039, 5164, 5995], 'shown': [752, 1641, 2900, 4190, 4736, 4764, 5996], 'interact': [754, 1005, 1259, 5322], 'different': [756, 1191, 1748, 3680, 3768, 3786, 4642, 4822, 5006, 5027, 6007, 6013, 6020], 'domain-containing': [762, 1706, 4490], 'specific': [765, 4652], 'locations': [767, 4654, 6015], '(see': [768], 'Refs.2Cheever': [769], 'Scholar;': [952], 'reviews,': [954], 'see': [955, 1353], 'Refs.': [956], '10Simonsen': [957], 'Stenmark': [959, 3548, 3566], 'E179-E182Crossref': [966], '(64)': [969], 'Scholar': [971], '11Wishart': [973], 'M.J.': [974, 5635], 'Taylor': [975], 'G.S.': [976], 'Dixon': [977], 'J.E.': [978], 'Cell.': [979, 3210, 3520, 4273, 5591, 5825], '105:': [981], '817-820Abstract': [982], 'Full': [983, 985, 1203, 1205, 1514, 1516, 1540, 1542, 3524, 3526, 3574, 3576, 4250, 4252, 5073, 5075, 5147, 5149, 5528, 5530, 5618, 5620, 5671, 5673, 5784, 5786], 'Text': [984, 986, 1204, 1206, 1515, 1517, 1541, 1543, 3525, 3527, 3575, 3577, 4251, 4253, 5074, 5076, 5148, 5150, 5529, 5531, 5619, 5621, 5672, 5674, 5785, 5787], 'PDF': [987, 1207, 1518, 1544, 3528, 3578, 4254, 5077, 5151, 5532, 5622, 5675, 5788], '(130)': [990], 'Several': [993], 'domains,': [995, 5103], 'including': [996], 'those': [997, 1012, 1366], 'Vam7p,': [999, 3294], 'SNX3,': [1000], 'p40phox,': [1003], 'PI(3)P.': [1007, 1833, 3098, 3378, 3415, 3665], 'They': [1008], 'also': [1010, 1639, 1961, 3364, 3667, 3752, 3922, 4062, 4074, 4763, 5098, 5348, 6095], 'vivo': [1017, 1829, 3430, 3632, 3654], '(2Cheever': [1018, 3231], '14': [1179], 'out': [1180, 5298], '15': [1182, 2450, 2493, 2774, 3393], 'from': [1185, 1929, 2078, 2086, 2110, 2116, 2125, 2350, 3763, 5026], 'yeast': [1186, 3202], 'PI(3)P': [1189, 2938, 2991, 3057, 3061, 3076, 3083, 3230, 3331, 3397, 3428, 3505, 3621, 4744, 4757, 4840, 4878, 4911, 5336, 5424], '(40Yu': [1193], 'Lemmon': [1195, 5139], 'Chem.': [1199, 1510, 1536, 3570, 4246, 5069, 5143, 5522, 5614, 5667], '276:': [1201, 5071], '44179-44184Abstract': [1202], '(165)': [1210], 'CPK': [1218], 'interacts': [1221, 3110, 4436, 5015], 'PI(4,5)P2': [1223, 4884, 4919], '(6Song': [1224, 2048, 2380], 'Scholar),': [1248, 1549, 2572, 4282, 5793], 'preferentially': [1258], 'PI(3,4)P2': [1261, 3746, 3878, 4083, 4874, 4907, 4965, 5002, 5346], '(5Kanai': [1262, 1933, 3926, 4920, 4966, 5352], 'shows': [1295, 3771, 3793, 4896, 4998, 5019], 'binding': [1296, 1831, 2039, 2372, 2377, 2409, 2471, 2516, 2717, 2870, 2920, 2953, 2978, 2984, 3026, 3062, 3307, 3320, 3326, 3344, 3362, 3412, 3419, 3622, 3677, 3706, 3744, 3795, 3832, 3854, 3873, 3879, 3888, 3911, 3914, 3957, 3968, 4043, 4046, 4053, 4067, 4077, 4367, 4409, 4758, 4854, 4860, 4949, 5000, 5025, 5028, 5043, 5167, 5187, 5226, 5260, 5276, 5303, 5344, 5425, 6037], 'C-terminal': [1299, 4439], 'SH3': [1300, 4440, 4489], '(9Hiroaki': [1302, 4442], 'Ago': [1304, 4444], 'Ito': [1306, 4446], 'Sumimoto': [1308, 4448], 'Kohda': [1310, 4450], 'Struct.': [1313, 4453], '8:': [1316, 4456], '526-530Crossref': [1317, 4457], '(149)': [1320, 4460], 'oxidase,': [1324, 1716], 'consisting': [1325], 'membrane-associated': [1328], 'subunits': [1329, 1367, 1399, 1427, 1440, 1465, 1707, 4573, 4597, 4650], 'cytosolic': [1331, 1426, 1457, 1704, 4596, 4649], 'subunits,': [1332], 'plays': [1333, 5497], 'very': [1335, 3890, 5499], 'important': [1336, 5500], 'role': [1337, 1552, 5501, 5984], 'immune': [1340], 'defense': [1341], 'system': [1342], 'neutrophils': [1344], 'phagocytic': [1347], '(for': [1349], 'recent': [1351], 'review,': [1352], 'Ref.': [1354], '12Babior': [1355], 'B.M.': [1356], 'Blood.': [1357, 4002], '1999;': [1358, 1511, 1614, 2565, 4275, 5827], '93:': [1359, 5754], '1464-1476Crossref': [1360], 'Defects': [1364], 'will': [1368, 1377, 4598], 'result': [1369], 'dysfunction': [1371], 'enzyme': [1374, 1445, 1453, 4607], 'clinically': [1376], 'cause': [1378], 'chronic': [1379, 1384, 3985], 'granulomatous': [1380, 1385, 3986], 'disease.': [1381], 'Patients': [1382], 'disease': [1386, 3987], 'suffer': [1387], 'severe,': [1388], 'recurrent': [1389], 'bacterial': [1390, 2865], 'fungal': [1392], 'infections.': [1393], 'resting': [1396, 4587], 'state,': [1397], 'differentially': [1404], '(gp91phox': [1409], 'p22phox)': [1411], 'cytoplasm': [1415, 4124], '(p40phox,': [1416], 'p67phox,': [1417, 1459], 'p47phox).': [1419], 'response': [1421], 'invasive': [1423], 'microorganisms,': [1424, 4594], 'translocate': [1431, 4306, 4532, 4599], 'fuse': [1436], 'membrane-bound': [1439, 1731, 4611], 'form': [1442, 1725, 4604], 'an': [1443, 1484, 2542, 4605, 4777, 4833, 4871], 'activated': [1444, 1721, 4590], 'complex.': [1446], 'core': [1448], 'part': [1449], 'active': [1452, 1478, 1650, 4606], 'consists': [1454], 'GTPase': [1461], 'Rac1/2,': [1462], 'gp91phox': [1466], 'p22phox,': [1468], 'required': [1472], 'assembly': [1475, 4619], 'complex': [1481, 1652, 1728, 4608], 'acting': [1482], 'adaptor': [1485], 'p67phox': [1487, 1565], '(13Diebold': [1488], 'B.A.': [1489, 3995], 'Bokoch': [1490], 'G.M.': [1491, 5639], 'Immunol.': [1493], '2:': [1495, 3522], '211-215Crossref': [1496], '(239)': [1499], '14Cross': [1502], 'A.R.': [1503, 1529, 3993, 5739], 'Erickson': [1504], 'R.W.': [1505], 'Curnutte': [1506, 3998], 'J.T.': [1507, 3999], '274:': [1512], '15519-15525Abstract': [1513], '(54)': [1521], '15DeLeo': [1524], 'F.R.': [1525], 'Ulman': [1526], 'K.V.': [1527], 'Davis': [1528], 'Jutila': [1530], 'K.L.': [1531, 5658], 'Quinn': [1532], 'M.T.': [1533], '271:': [1538], '17013-17020Abstract': [1539], 'likely': [1556, 5311, 6062], 'be': [1558, 1643, 3333, 3839, 4318, 4474, 5105], 'regulator': [1560], '(16Vergnaud': [1566], 'Paclet': [1568], 'M.H.': [1569], 'El': [1570], 'Benna': [1571, 1589], 'Pocidalo': [1573], 'Morel': [1575, 1603], 'Eur.': [1577], 'Biochem.': [1579, 1627, 2563], '2000;': [1580, 1629, 3552, 3571, 5523, 5550, 5593, 5668], '267:': [1581], '1059-1067Crossref': [1582], '(59)': [1585], '17El': [1588], 'Dang': [1591], 'P.M.': [1592], 'Andrieu': [1593], 'V.': [1594], 'Vergnaud': [1595], 'Dewas': [1597], 'C.': [1598, 5688], 'Cachia': [1599], 'O.': [1600, 5541], 'Fay': [1601], 'Chollet-Martin': [1605], 'Hakim': [1607], 'Gougerot-Pocidalo': [1609], 'Leukocyte': [1612], '66:': [1615], '1014-1020Crossref': [1616], '(44)': [1619], '18Tsunawaki': [1622], 'Yoshikawa': [1624], '(Tokyo).': [1628], '128:': [1630], '777-783Crossref': [1631], '(23)': [1634], 'critical': [1644, 5893], 'function': [1647, 1994, 4342, 4569, 5396, 5487, 6028], 'enzymatic': [1651], '(4Ellson': [1653, 1750, 1848, 3118, 4655], 'little': [1695, 3072, 4132], 'known': [1697, 3508], 'two': [1703, 1734, 3282, 3919, 5999], 'activation': [1713, 1976, 4621, 5504, 5564], 'especially': [1717, 5888], 'how': [1718], 'they': [1719, 3867], 'translocated': [1723, 5438], 'functional': [1727], 'subunits.': [1732, 4612], 'reports': [1735, 3117], 'indicated': [1737, 4167], 'report': [1836, 4728, 4895], 'above': [1841], 'regarding': [1843], 'Furthermore,': [1916, 5716], 'profile': [1922], 'differs': [1928], 'We': [1960, 2853, 2964, 3416, 3666, 3751, 4092, 4463, 4761, 4810, 5200, 6073, 6094], 'IGF-1': [1975, 2810, 4386, 4522, 5558, 5849], 'targeting': [1984, 1993, 3650, 4468, 5395, 5486, 6027], 'sensitive': [1986, 4291], 'domain.': [2006, 4733, 6072], 'controlled': [2028, 6022], 'All': [2033, 2242, 3099, 5379], 'phospholipids': [2034, 2077, 2583, 2611, 2720, 2931, 5126], 'used': [2035, 2406, 2578], 'liposome': [2038, 2371, 2376, 2435, 2977, 3002, 3017, 3044, 3068, 3319, 3361, 3390, 3783, 3853, 3910, 3967, 4042, 4052, 4859, 4948, 5225, 5275], 'assays': [2040, 2549, 2729, 3686, 5227, 5277], 'were': [2041, 2084, 2108, 2201, 2226, 2245, 2259, 2266, 2288, 2465, 2550, 2577, 2584, 2732, 2743, 2756, 2771, 2799, 2813, 2845, 3700, 4637, 4802, 5433], 'purchased': [2042, 2085], 'prepared': [2044], 'before': [2047, 2689, 2764, 3925], 'Nitrocellulose': [2073], 'spotted': [2075, 2598, 2887, 2927], '100': [2079, 2432, 2468, 2513], '1.56': [2081], 'pmol/spot': [2082], '(PIP-ArrayTM)': [2083, 2932], 'Echelon': [2087], 'Research': [2088], 'Laboratories.': [2089], 'DNA': [2090, 2248], 'fragments': [2091], 'encoding': [2092, 2254], '(amino': [2097, 2105, 2164, 2180], '9–140)': [2099], '2–125)': [2107], 'amplified': [2109], 'human': [2112, 2117, 2780], 'cDNA': [2113], 'library': [2114], '(CLONTECH,': [2115], 'spleen)': [2118], 'cloned': [2120, 2243], 'into': [2121, 2149, 2261, 3449, 5410], 'pXL1a': [2122, 2252], 'vector': [2123, 2151, 3448], '(modified': [2124], 'pET15b)': [2126], 'cleavage': [2129], 'NheI': [2131], 'SalI': [2133], 'enzymes.': [2134], 'For': [2135, 2767, 2795, 3875], 'fusion,': [2139], 'coding': [2141], 'sequence': [2142, 2163], 'was': [2147, 2168, 2331, 2347, 2405, 2419, 2428, 2505, 2510, 2524, 2538, 2612, 2644, 2667, 2686, 2708, 2721, 2882, 2894, 2933, 2956, 2998, 3013, 3065, 3346, 3386, 3455, 3597, 3808, 3882, 3889, 3980, 4047, 4073, 4084, 4120, 4290, 4790, 5194, 5237, 5263, 5417], 'subcloned': [2148], 'pEGFP-C1': [2150], '(CLONTECH)': [2152], 'PCR-mediated': [2155], 'addition': [2156, 2173, 3586], 'ofXhoI': [2157, 2174], 'PstI': [2159], 'sites': [2160, 2177, 4151, 4162], 'p40-PX': [2162, 2904, 2935, 2980, 2996, 3011, 3035, 3064, 3303, 3696, 3717], '13–133).': [2166], 'similarly': [2169, 2227], 'generated': [2170, 2228, 2854, 3296, 3668, 4022, 4358, 4501, 5202], 'BamHI': [2176], 'p47-PX': [2179, 2225, 3698, 3702, 3724, 3757, 3776, 3806, 3820, 3881, 3916, 3954, 5018, 5051, 5094, 5169, 5189, 5235, 5887, 5956], '2–116).': [2182], 'double': [2185, 2217, 3187, 3299, 3368, 3402, 3617, 4505, 4752, 4795], 'made': [2202], 'using': [2203, 2230, 2874, 2975, 3311, 3683], 'QuikChangeTM': [2205], 'XL': [2206], 'site-directed': [2207], 'mutagenesis': [2208], 'kit': [2209], '(Stratagene)': [2210], 'following': [2211, 2735, 2804], "manufacturer's": [2213], 'protocol.': [2214], 'P73A/P76A': [2216, 4504], 'R42Q/P73A/P76A': [2221, 4509], 'triple': [2222, 4510], 'wild': [2232], 'type': [2233], 'template.': [2241], 'plasmids': [2244, 2253], 'confirmed': [2246], 'sequencing.': [2249], 'recombinant': [2251], 'corresponding': [2256, 3298], 'transformed': [2260], 'Escherichia': [2262], 'coli': [2263], 'BL21(DE3).': [2264], 'Cells': [2265, 2287, 2812, 2844], 'grown': [2267], 'at': [2268, 2284, 2338, 2457, 2460, 2495, 2639, 2648, 2672, 2939, 2948, 2959, 3336, 3841, 4150, 4173, 4580, 4887, 5278, 5876], '37': [2269], '°C': [2270, 2650], 'A600': [2272], '0.5–0.6': [2273], 'induced': [2275, 5719], '0.1': [2277], 'mm': [2278, 2296, 2301, 2309, 2315, 2357, 2360, 2363, 2438, 2474, 2477, 2480, 2626, 2629], 'isopropyl': [2279], 'β-d-thiogalactoside': [2280], '6': [2282], 'h': [2283, 2638, 2671, 2763], '18': [2285], '°C.': [2286, 2340, 2462], 'lysed': [2289], 'sonication': [2291], 'extraction': [2293], 'buffer': [2294, 2355, 2436, 2472, 2624, 2850], '(25': [2295, 2356, 2437, 2473], 'Tris·HCl,': [2297, 2358, 2439, 2475, 2627], 'pH': [2298, 2365, 2442, 2482, 2634], '7.5,': [2299], '150': [2300, 2359, 2440, 2476, 2628], 'NaCl,': [2302, 2361, 2478, 2630], '5%': [2303, 2989, 3381, 3800, 4051], 'glycerol,': [2304], '1%': [2305, 2819, 3074], 'Triton': [2306, 2825], 'X-100,': [2307], '10': [2308, 2317, 2321, 2455, 2485, 5005], 'β-mercaptoethanol,': [2310], 'protease': [2312], 'inhibitors': [2313], '1': [2314, 2479, 2637, 2670, 2834, 3053], 'phenylmethylsulfonylfluoride,': [2316], 'μg/ml': [2318, 2322, 2657, 2778], 'leupeptin,': [2319], 'aprotinin)': [2323], 'then': [2325, 2368, 2429, 2499, 2597, 2645, 2691, 2788, 2814, 2828, 4107, 5201], 'cleared': [2326], 'centrifugation.': [2328], 'supernatant': [2330, 2504], 'incubated': [2332, 2491, 2646, 2668, 2692, 2772, 2829, 2883], 'Ni2+-nitrilotriacetic': [2334], 'acid-agarose': [2335], 'beads': [2336, 2352], '(Qiagen)': [2337], '4': [2339, 2461, 2649], 'After': [2341, 2660, 2752], 'serial': [2342], 'wash,': [2343], 'fusion': [2345], 'finally': [2348], 'eluted': [2349], 'elution': [2354], '125–250': [2362], 'imidazole,': [2364], '7.5)': [2366, 2483, 2635], 'buffer-exchanged': [2369], 'buffer.': [2373, 2517, 2843], 'A': [2374, 3186, 3688, 3749, 4089], 'assay': [2378, 3316, 3363, 3850, 3855, 4039, 4054, 4061, 4997], 'protocol': [2379], 'Scholar)': [2404, 3219, 5082], 'experiments': [2410, 5007], 'minor': [2412], 'modification.': [2413], 'phospholipid': [2415], 'mixture': [2416, 2427, 2588], '(100': [2417], 'μg/reaction)': [2418], 'dried': [2420, 2426], 'SpeedVac': [2423], '(Savant).': [2424], 'resuspended': [2430, 2466, 2511], 'μl': [2433, 2469, 2514, 2520], 'mmNaCl,': [2441], '7.5);': [2443], 'sonicated': [2444], 'bath': [2447], 'sonicator': [2448], 'min;': [2451], 'spun': [2453], 'min': [2456, 2494, 2775, 2832], '14,000': [2458], 'rpm': [2459], 'liposomes': [2464, 2986, 3049, 3086, 3092, 3376, 3760, 3798, 3824, 5203], 'MgCl2,': [2481], 'containing': [2484, 3093, 3377, 3392, 3785, 3799, 3825], 'μg': [2486], 'purified': [2488, 2880], 'room': [2496, 2640, 2673], 'temperature': [2497, 2674], 'centrifuged': [2500], 'before.': [2502], 'saved,': [2506], 'pellet': [2509], 'Then': [2518], '25': [2519], 'fractions': [2523], 'analyzed': [2525], 'SDS-PAGE': [2527, 3773], 'Coomassie': [2529], 'Blue': [2530], 'staining.': [2531], 'intensity': [2533], 'stained': [2536], 'bands': [2537], 'quantitatively': [2539], 'determined': [2540], 'LKB': [2543], 'Ultroscan': [2544], 'laser': [2545], 'densitometer.': [2546], 'Protein-lipid': [2547, 2727], 'overlay': [2548, 2728, 2877, 3315, 3324, 3685, 3849, 3894, 3964, 4038, 4060, 4826, 4996, 5184, 5307], 'performed': [2551, 2733], 'previously': [2553, 5350], 'described': [2554], '(19Dowler': [2555], 'Currie': [2557], 'R.A.': [2558, 5641], 'Downes': [2559], 'P.C.': [2560], 'Alessi': [2561], 'D.R.': [2562, 5583, 5643], '342:': [2566], '7-12Crossref': [2567], '(127)': [2570], 'except': [2573], 'His6-tagged': [2575], 'study.': [2581, 5010], 'Various': [2582], 'dissolved': [2585], 'methanol': [2590], 'chloroform': [2592], '1:1': [2594], 'ratio': [2595], 'onto': [2599], 'nitrocellulose': [2600], '(Hybond-C;': [2602], 'Amersham': [2603], 'Biosciences)': [2604], 'air-dried.': [2606], 'various': [2610, 2889], 'blocked': [2613], '3%': [2615], 'fatty': [2616], 'acid-free': [2617], 'bovine': [2618, 2821], 'serum': [2619, 2822], 'albumin': [2620], '(Sigma)': [2621, 2808], 'TBST': [2623, 2663, 2711], '(50': [2625], '0.1%': [2631], 'Tween': [2632], '20,': [2633], 'temperature.': [2641], 'overnight': [2647], 'same': [2653, 2737, 2842, 2849, 3693, 5874], 'solution': [2654], '0.2': [2656], 'His-tagged': [2658, 2715, 2861, 3670], 'protein.': [2659], 'wash': [2661], 'buffer,': [2664, 2712], '1:1,000': [2676], 'dilution': [2677, 2696], 'anti-His': [2680, 2897], 'monoclonal': [2681], 'antibody': [2682, 2703], '(Novagen).': [2683], 'washed': [2687, 2709, 2846], '1:5,000': [2695], 'alkaline': [2698], 'phosphatase-conjugated': [2699], 'goat': [2700], 'anti-mouse': [2701], 'secondary': [2702], '(Bio-Rad).': [2704, 2726], 'Finally,': [2705], 'detected': [2722, 2895, 2958, 4048, 4176], 'chemiluminescence': [2725], 'PIP-ArrayTM': [2731], 'procedure': [2738], 'above.': [2740], 'maintained': [2744], 'transfected': [2746, 4100, 4800, 5840], 'calcium': [2749], 'phosphate': [2750], 'method.': [2751], '16': [2753], 'h,': [2754], 'changed': [2757], 'serum-free': [2759], 'medium': [2760], 'further': [2765, 2965, 3023], 'treatment.': [2766], 'transferrin': [2768, 2781, 3487], 'labeling,': [2769], '5': [2777, 3764], 'rhodamine-conjugated': [2779, 2836, 3486, 4180, 4775], '(Molecular': [2782, 2838], 'Probes,': [2783], 'Inc.,': [2784], 'Eugene,': [2785], 'OR)': [2786], 'fixed': [2789, 2800], '4%': [2791, 2802], 'formaldehyde': [2792, 2803], 'PBS.': [2794], 'actin': [2796, 5810], 'staining,': [2797], 'treatment': [2805], 'wortmannin': [2807, 5461], 'and/or': [2809], '(Calbiochem).': [2811], 'permeabilized': [2815], 'PBS': [2817], 'fetal': [2820], '0.5%': [2824], 'X-100': [2826], '30': [2831], 'unit/ml': [2835], 'phalloidin': [2837, 4181], 'Probes)': [2839], 'mounted.': [2852], 'expressed': [2863], 'investigated': [2868], 'protein-lipid': [2876, 3314, 3323, 3684, 3848, 3893, 3963, 4037, 4059, 4825, 4995, 5183, 5306], 'assay.': [2878, 2979, 3321, 3969, 4044], 'phospholipids,': [2890], 'bound': [2892, 2936, 2943, 3758, 3822, 3862, 3898, 4866], 'antibody.': [2898], 'As': [2899, 5180], 'Fig.': [2902, 3791], '1A,': [2903], 'exhibited': [2905, 3703], 'high': [2906, 2950, 3338, 3906, 4747, 4904], 'PI(3)P,': [2909, 3005, 3029, 3112, 3310, 3730, 4069, 5017, 6039], 'low': [2910, 2940, 4888], 'PI(4)P,': [2913, 3740, 4070], 'PI(5)P,': [2914, 3731], 'PI(3,5)': [2916], 'P2,': [2917], 'no': [2919, 3742, 4312, 4999, 5186, 5259], 'phosphoinositides.': [2923, 3021, 3769, 3827, 3865, 5045], 'When': [2924, 3691], 'lipid': [2925, 4889, 5214, 5325], 'serially': [2929], 'diluted': [2930], 'employed,': [2934], 'concentrations': [2941, 3081, 3339, 3844, 5280], 'PI(4)P': [2945, 3353, 4844, 4886, 4915], 'PI(5)P': [2947, 3355, 4072, 4838, 4880, 4917], 'relatively': [2949, 3337, 3726, 3905], 'concentrations,': [2951], 'whereas': [2952, 3790, 3815, 4076], 'PI(3,5)P2': [2955, 3887, 4846, 4876, 4909, 5338], 'only': [2957, 3335], '100-pmol': [2961], 'spot': [2962], '(Fig.1B).': [2963], 'studied': [2966], 'selectivity': [2969, 5041], 'displayed': [2981], 'remarkably': [2982], 'selective': [2983], 'contain': [2988, 3051, 3762], '(Fig.': [2992, 3058, 3340, 3356, 3398, 3488, 3633, 3718, 3747, 4055, 4087, 4157, 4182, 4320, 4402, 4537, 5196, 5465], '1C).': [2993], 'About': [2994], '30%': [2995], 'observed': [2999, 3014, 3066, 3387, 4319, 5351, 5836], 'pellets': [3003, 3018, 3045, 3069, 3391, 3784], 'less': [3007, 3734, 3816, 3840, 5231], 'than': [3008, 3095, 3380, 3817, 4547, 5232, 5248, 5935, 5968], '8%': [3009], 'To': [3022, 4011, 4337, 4496], 'characterize': [3024], 'quantified': [3031], 'percentage': [3033, 3755, 3907, 5250], 'supernatants': [3040, 3779], 'after': [3046, 4798], 'incubation': [3047], 'between': [3052, 4353, 4479, 4551, 5111, 5973], '20%': [3055, 3395], '1D).': [3059, 3399], 'increased': [3078], 'increasing': [3080], 'until': [3087], 'reached': [3089], 'saturation': [3090], 'more': [3094, 3727, 5806, 6061], '15%': [3096, 3766, 5233], 'results': [3102, 3196, 3636, 4541, 4724], 'selectively': [3109, 3409, 3661], 'consistent': [3113, 3638, 3956, 4952], 'mutation': [3188, 3973, 4017], '(Y42A/L48Q)': [3189], 'within': [3190, 5955], 'Vam7p': [3195], 'vacuolar': [3198], 'trafficking': [3199], 'defects': [3200], '(20Sato': [3203], 'Darsow': [3205], 'Mol.': [3209, 3519, 4272, 5590, 5824], '1998;': [3212, 3521, 4247, 5144, 5615], '18:': [3213], '5308-5319Crossref': [3214], '(166)': [3217], 'caused': [3220, 4349, 4475], 'loss': [3223], 'Since': [3280, 4184], 'these': [3281, 4174, 5381], 'conserved': [3286], '(Y59A/L65Q)': [3301], 'examined': [3305, 3675, 3753, 4108, 4378, 4515], 'assays,': [3325, 3895, 4827, 4861, 5308], 'could': [3332, 4317, 4391, 4473], 'seen': [3334, 5099], '1B).': [3341, 3719], 'overall': [3343], 'reduced': [3347], 'level': [3350], 'similar': [3351, 3628, 4064, 5868], '1,': [3357], 'Aand': [3358], 'B).': [3359, 3690, 4091, 5199], 'showed': [3365, 3725, 3856, 3955, 4063, 4832], 'lost': [3370, 4791], 'Less': [3379], 'total': [3383, 5213], 'mutated': [3384], 'decreases': [3410], 'tested': [3417, 3801, 4284, 5165], 'isolated': [3423], 'fusing': [3432], 'C': [3436], 'terminus': [3437], 'transfecting': [3444], 'expression': [3447], 'found': [3456, 3809, 4121, 5238, 5726], 'numerous': [3460], 'cytoplasmic': [3461, 3604], 'vesicles': [3462], 'concentrated': [3463], 'perinuclear': [3466], 'region': [3467], '(Fig.2A).': [3468], 'This': [3469, 4404, 4786, 5962], 'pattern': [3470, 3478, 3630], 'staining': [3472, 3594, 3605, 4178], 'overlapped': [3473], 'almost': [3474, 4754], 'completely': [3475, 5915], 'fluorescence': [3480], 'obtained': [3481], 'loading': [3483], '2,B': [3489], 'C),': [3491], 'indicating': [3492], 'endosomal': [3500, 4781], 'vivo,': [3503], 'where': [3504], 'reside': [3510], '(21Burd': [3515], 'C.G.': [3516], '157-162Abstract': [3523], '(425)': [3531], '22Gillooly': [3534], 'D.J.': [3535, 3565], 'Morrow': [3536], 'I.C.': [3537], 'Lindsay': [3538], 'Gould': [3540], 'R.': [3541, 5637], 'Bryant': [3542], 'N.J.': [3543], 'Gaullier': [3544], 'Parton': [3546], 'R.G.': [3547], 'EMBO': [3550, 4226], '19:': [3553, 4276, 5828], '4577-4588Crossref': [3554], '(863)': [3557], '23Gaullier': [3560], 'J.M.': [3561, 4271, 5128, 5745, 5823], 'Ronning': [3562], 'E.': [3563], 'Gillooly': [3564], '275:': [3572, 5648, 5669], '24595-24600Abstract': [3573], '(119)': [3581], 'Upon': [3584], 'inhibitor': [3591, 4296], 'wortmannin,': [3592, 4302, 4805], 'lost;': [3598], 'instead,': [3599], 'appeared': [3601, 4147], 'diffuse': [3603, 3629], 'nucleus': [3611, 4130], '(Fig.2D).': [3612], 'Likewise,': [3613], 'incorporation': [3614], 'mutation,': [3618], 'diminishes': [3620], 'resulted': [3625], '2E).': [3634], 'These': [3635, 4159, 4540], 'notion': [3641], 'capable': [3648], 'based': [3655], 'strongly': [3663], '(Fig.3,': [3687], 'amounts': [3694, 3787], 'used,': [3701], 'much': [3704], 'weaker': [3705], 'all': [3708, 3835, 4369, 5287], 'tested,': [3712], 'compared': [3713], 'Among': [3720], 'seven': [3722], 'PI(3,4,5)P3,': [3733, 3959, 4081, 5804], 'PI(3,5)P2,': [3737, 3814, 4079], 'PI(4,5)P2,': [3738, 4080, 4848], 'detectable': [3743], '3,': [3748, 4088], 'andB).': [3750], 'Fig.3C': [3770], 'gels': [3774], '3D': [3792], 'percentage.': [3796], '40%': [3804], 'PI(3,4)P2or': [3813], '25%': [3818], 'difference': [3830], 'among': [3834], 'tended': [3837], 'phosphoinositide': [3843, 4019, 4408, 5024, 5937], '(Fig.3D).': [3845], 'Both': [3846], 'most': [3864, 4868, 5256], 'differ': [3868], 'order': [3871, 4834, 4872, 5158, 5390], 'affinity.': [3874], 'example,': [3876], 'observed,': [3884], 'weak': [3891], 'them': [3902], 'assays.': [3912, 4823, 5029], 'Meanwhile,': [3953], 'point': [3972], '(R42Q)': [3974], 'identified': [3981], 'patients': [3983], '(24Noach': [3988], 'Rae': [3990], 'Cross': [3992], 'Ellis': [3994], 'Newburger': [3996], 'P.E.': [3997], 'Heyworth': [4000], 'P.G.': [4001], '97:': [4004], '305-311Crossref': [4005], '(68)': [4008], 'investigate': [4012], 'effects': [4014], 'binding,': [4020], 'applied': [4032], 'No': [4045], '3E).': [4056], 'Subsequently,': [4057], 'results.': [4065], 'reduced,': [4075], 'totally': [4085], 'undetectable': [4086], 'fused': [4093, 4372, 5403], 'EGFP,': [4099, 4376], 'IGF-1-stimulated': [4112], '-unstimulated': [4114], 'basal': [4117], 'throughout': [4122], 'if': [4133], 'any': [4134], 'association': [4135], '(Fig.4A).': [4140, 5429], 'IGF-1,': [4145, 5436], 'collect': [4149], 'folding': [4154], 'protrusion': [4156], '4D).': [4158], 'apparently': [4161, 5086, 5942], 'ruffling,': [4165], 'concentration': [4170, 5571], 'F-actin': [4172, 4316, 4384, 4401], 'sites,': [4175, 5443], '4E).': [4183], 'factor-stimulated': [4186], 'membrane-ruffling': [4187], 'coincide': [4192], 'products': [4196, 5385], 'several': [4198], 'systems': [4199], '(25Kotani': [4200], 'Yonezawa': [4202, 5769], 'Hara': [4204, 5767], 'Ueda': [4206], 'Kitamura': [4208], 'Sakaue': [4210], 'Ando': [4212], 'Chavanieu': [4214], 'Calas': [4216], 'B.': [4217, 4237, 4241, 5606], 'Grigorescu': [4218], 'Nishiyama': [4220], 'Waterfield': [4222], 'M.D.': [4223], 'Kasuga': [4224, 5771], '1994;': [4228, 5781], '13:': [4229], '2313-2321Crossref': [4230], '(328)': [4233], '26Kim': [4236], 'Cheng': [4238], 'H.L.': [4239], 'Margolis': [4240], 'Feldman': [4242], 'E.L.': [4243], '273:': [4248, 5145, 5616], '34543-34550Abstract': [4249], '(69)': [4257], '27Vollenweider': [4260], 'Clodi': [4262, 5814], 'Martin': [4264, 5816], 'S.S.': [4265, 5735, 5817], 'Imamura': [4266, 5818], 'Kavanaugh': [4268, 5820], 'W.M.': [4269, 5821], 'Olefsky': [4270, 5744, 5822], '1081-1091Crossref': [4277, 5829], 'whether': [4285, 4339], 'EGFP-P47-PX': [4289], 'wortmannin.': [4297], 'presence': [4300], 'failed': [4304], 'ruffles': [4309, 5449, 5844, 5864], '(Fig.4G),': [4310], 'substantial': [4313], 'colocalization': [4314, 4382, 5453, 5837], '4,': [4321], 'H': [4322], 'I).': [4324], 'membrane-targeting': [4327, 4341, 4568], 'regulated': [4331], 'test': [4338, 4497], 'interactions': [4352], 'p47-PX,': [4363], 'had': [4365], 'diminished': [4366], 'PIPsin': [4370], 'stimulation.': [4387, 4523], 'Surprisingly,': [4388], 'colocalize': [4399, 4773], '5,A–C).': [4403], 'suggests': [4405, 5963], 'subunit,': [4427], 'contains': [4431], 'PXXP': [4433, 5953], 'motif': [4434, 4482, 5954], 'hypothesized': [4464], 'p47phoxPX': [4471, 5904], 'interaction': [4478, 4550, 5269, 5972], 'polyproline': [4481], 'hypothesis,': [4499], 'their': [4516], 'mutants': [4526], 'possessed': [4528], '5,': [4538], 'D–I).': [4539], 'interactions,': [4545, 5966], 'simple': [4548, 5936, 5970], 'PX-SH3': [4549, 5971], 'protein(s)': [4559], 'might': [4564], 'contribute': [4565, 6064], 'p47phox.': [4571], 'separately': [4578], 'located': [4579], 'cytosol': [4584], 'state.': [4588], 'Once': [4589], 'invading': [4593], 'detailed': [4615], 'mechanism': [4616, 5933], 'yet': [4627], 'understood.': [4628], 'may': [4645, 5104, 5851], 'potentially': [4646], 'affinity,': [4748], 'abolishes': [4755], 'vitro.': [4760, 5920], 'able': [4771], 'transferrin,': [4776], 'organelle': [4778], 'marker': [4779], 'PI(3)P-dependent': [4787], 'treated': [4803, 5434], 'inhibitor.': [4809], 'varied': [4818], 'patterns': [4820], 'preference': [4836, 5330], '>': [4839, 4843, 4845, 4877, 4885, 4908, 4910, 4914], '=': [4841, 4847, 4875, 4879, 4881, 4883, 4912, 4916, 4918], 'PI(3,4,5)P3': [4842, 4882, 4913, 5573, 5733, 5890], 'did': [4851], 'PI(3,4)P2.': [4856], 'concentration.': [4890], 'contrast,': [4892], 'previous': [4894, 5224, 5253], 'our': [5009], 'Unlike': [5011], 'p40-PX,': [5012], 'distinctly': [5014], 'conflicting': [5020], 'evidence': [5021], 'seems': [5031, 5270], 'clear': [5040], 'noticed': [5049], 'highly': [5054], 'positively': [5055], 'charged': [5056, 5121, 5178], '(28Ebisu': [5057], 'K': [5058], 'Nagasawa': [5059], 'Watanabe': [5061], 'Miyano': [5063], 'Tamura': [5065], '24498-24505Abstract': [5072], '(35)': [5080], 'domain,': [5083, 5401], 'polyphosphorylation': [5085], 'gives': [5087], 'negative': [5089], 'charge.': [5090], 'nonselectivity': [5092], 'PH': [5102], 'due': [5106], 'nonspecific': [5108, 5267, 5302], 'electrostatic': [5109, 5268], 'attraction': [5110], 'positive': [5113], 'face': [5114], 'negatively': [5120, 5177], 'surfaces': [5122], 'formed': [5123], 'acidic': [5125], '(29Kavran': [5127], 'Klein': [5129], 'D.E.': [5130], 'Lee': [5131], 'Falasca': [5133], 'Isakoff': [5135], 'Skolnik': [5137], 'E.Y.': [5138], '30497-30508Abstract': [5146], '(379)': [5154], 'address': [5160], 'point,': [5162], 'PS,': [5173], 'phospholipids.': [5179], 'assay,': [5185], 'PS': [5193, 5208, 5242], 'presented': [5195], '3,A': [5197], 'comprised': [5209], '80%': [5210], 'contained': [5216], 'up': [5217], '16-fold': [5219], 'p47-PX.': [5229, 5293], '(data': [5243], 'shown),': [5245], 'lower': [5247], 'studies': [5254], 'present.': [5264], 'Hence,': [5265], 'exist': [5272], 'unlikely': [5283], 'account': [5285], 'Although': [5294], 'cannot': [5296, 5957], 'rule': [5297], 'possibility': [5300], 'exists': [5304], 'possesses': [5318, 5907], 'multiple': [5324], 'ligands,': [5326], 'since': [5327], 'displays': [5329], 'PI(3,4,5)P3and': [5332], 'study,': [5341], '3′-phosphoinositides': [5382], '3-kinases.': [5388], 'examine': [5392], 'EGFP': [5406], 'introduced': [5408], 'unstimulated': [5414], 'endosomes,': [5421], 'despite': [5422], 'when': [5431], 'discrete': [5440], 'corresponded': [5445], 'evidenced': [5451], 'phalloidin-stained': [5457], 'F-actin;': [5458], 'pretreatment': [5459], 'abolished': [5462], 'phenomenon': [5464], '4).': [5466], '(30Bae': [5508], 'Y.S.': [5509], 'Sung': [5510], 'Kim': [5512], 'O': [5513], 'Hur': [5514], 'K.C.': [5515], 'Kazlauskas': [5516], 'Rhee': [5518], 'S.G.': [5519], '275': [5524], '(K': [5525], 'yJ):': [5526], '10527-10531Abstract': [5527], '(283)': [5535], '31Yamanori': [5538], 'Inanami': [5540], 'Nagahata': [5542], 'Cui': [5544], 'Kuwabara': [5546], 'FEBS': [5548], 'Lett.': [5549], '467:': [5551], '253-258Crossref': [5552], '(125)': [5555], 'insulin': [5560, 5721], 'induce': [5562], 'increase': [5569], '(32Lawlor': [5578], 'Feng': [5580], 'Everding': [5582], 'Sieger': [5584], 'Stewart': [5586], 'C.E.H.': [5587], 'Rotwein': [5588], '20:': [5594], '3256-3265Crossref': [5595], '(63)': [5598], '33Okubo': [5601], 'Blakesley': [5603], 'V.A.': [5604], 'Stannard': [5605], 'Gutkind': [5607], 'Le': [5609], 'Roith': [5610], '25961-25966Abstract': [5617], '(73)': [5625], '34Dudek': [5628], 'Datta': [5630], 'S.R.': [5631], 'Franke': [5632], 'T.F.': [5633], 'Birnbaum': [5634], 'Yao': [5636], 'Segal': [5640], 'Kaplan': [5642], 'Greenberg': [5644], 'M.E.': [5645], 'Science.': [5646], '1997;': [5647], '661-665Crossref': [5649], '(2222)': [5652], '35Roudabush': [5655], 'F.L.': [5656], 'Pierce': [5657], 'Maudsley': [5659], 'Khan': [5661], 'K.D.': [5662], 'Luttrell': [5663], 'L.M.': [5664], '22583-22589Abstract': [5670], '(233)': [5678], '36Gagnon': [5681], 'Dods': [5683], 'Roustan-Delatour': [5685], 'N.': [5686], 'Chen': [5687], 'Sorisky': [5689], 'Endocrinology.': [5691], '142:': [5693], '205-212Crossref': [5694], '(37)': [5697], '37Sorisky': [5700], 'Pardasani': [5702], 'Lin': [5704], 'Obes.': [5706], 'Res.': [5707], '4:': [5709, 5782], '9-19Crossref': [5710], '(15)': [5713], 'ruffling': [5718], 'factors': [5724], 'correlate': [5728], 'production': [5731], '(38Martin': [5734], 'Rose': [5736], 'D.W.': [5737], 'Saltiel': [5738], 'Klippel': [5740], 'Williams': [5742], 'L.T.': [5743], 'Natl.': [5747], '8401-8406Crossref': [5755], '(60)': [5758], '39Wennstroem': [5761], 'Cooke': [5765], 'Jackson': [5773], 'Claesson-Welsh': [5775], 'Curr.': [5779], '385-393Abstract': [5783], '(395)': [5791], 'induction': [5796], 'SHIP,': [5798], '5′-phosphatase': [5801], 'dephosphorylates': [5803], 'causing': [5805], 'PI(3,4)P2,': [5807], 'eliminates': [5808], 'rearrangement': [5811], '(27Vollenweider': [5812], 'formation': [5861], 'either': [5866], 'actually': [5871], 'pathway,': [5875], 'least': [5877], 'Also,': [5882], 'seemingly': [5892], 'association.': [5897, 5961], 'R42A': [5900], 'targeting,': [5912], 'Thus,': [5921], 'recruitment,': [5938], 'although': [5939], 'downstream': [5943], 'activation.': [5947], 'mutations': [5950], 'abolish': [5958], 'protein(s),': [5981], 'play': [5982], 'summary,': [5993], 'pathways': [6021], '3-kinase.': [6025], 'directly': [6034, 6046], 'involves': [6035], 'Interactions': [6056], 'thank': [6074, 6096], 'Dr.': [6075, 6084, 6088, 6097], 'Michael': [6076], 'advice': [6082], 'Chuanyou': [6085], 'Kimmy': [6089], 'Yuan': [6090], 'technical': [6092], 'help.': [6093], 'Zhen': [6098], 'Jiang': [6100], 'members': [6102], 'laboratory': [6106], 'helpful': [6108], 'discussion.': [6109]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2058505728', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-24T14:55:43.709941', 'created_date': '2016-06-24'}
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