Publication Information

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2546, 2568, 2857, 2991, 3068, 3227, 3231, 3254, 3268, 3304, 3321, 3363, 3408, 3421, 3424, 3433, 3481, 3494, 3512, 3546, 3587, 3590, 3687, 3699, 3716, 3770, 3902, 3928, 3942, 3980, 4001, 4061, 4077, 4113, 4173, 4368, 4414, 4422, 4490, 4526, 4543, 4555, 4586, 4635, 4730, 4760, 4899, 4907], 'minimize': [16], 'disability': [17], 'and': [18, 25, 28, 57, 95, 121, 132, 165, 189, 252, 288, 310, 352, 395, 401, 413, 421, 494, 530, 549, 584, 608, 654, 658, 667, 723, 742, 848, 927, 986, 1104, 1109, 1116, 1121, 1157, 1195, 1321, 1341, 1395, 1419, 1480, 1531, 1557, 1583, 1589, 1600, 1665, 1693, 1725, 1818, 1833, 1849, 1885, 1908, 1980, 2047, 2101, 2204, 2222, 2323, 2337, 2388, 2421, 2513, 2563, 2665, 2669, 2706, 2749, 2787, 2826, 2910, 2961, 2998, 3025, 3061, 3149, 3198, 3271, 3287, 3323, 3351, 3531, 3583, 3630, 3654, 3825, 3914, 3964, 4025, 4028, 4046, 4098, 4125, 4142, 4186, 4205, 4214, 4221, 4278, 4331, 4334, 4341, 4373, 4385, 4435, 4471, 4508, 4520, 4535, 4570, 4608, 4611, 4670, 4691, 4924], 'prolong': [19], 'life,': [20], 'facilitate': [22], 'general': [23, 187, 2012, 2899, 2941, 4702], 'social': [24], 'physical': [26], 'well-being,': [27], 'help': [30], 'each': [31], 'patient': [32, 1025, 2145, 2971], 'achieve': [33], 'full': [34], 'potential': [35, 646, 855], '(': [36, 62, 143, 198, 241, 316, 389, 459, 520, 545, 633, 744, 757, 798, 825, 859, 901, 939, 971, 1035, 1057, 1072, 1250, 1323, 1372, 1425, 1560, 1634, 1708, 1780, 1826, 1868, 1910, 1934, 1952, 1969, 1998, 2020, 2115, 2139, 2170, 2238, 2397, 2464, 2533, 2604, 2650, 2725, 2881, 2935, 3045, 3095, 3157, 3239, 3311, 3354, 3410, 3435, 3484, 3605, 3703, 3763, 3794, 3863, 3904, 3976, 4042, 4086, 4101, 4161, 4291, 4375, 4424, 4533, 4620, 4697, 4738, 4793], '43).': [37], 'Advances': [38], 'in': [39, 46, 50, 116, 155, 226, 239, 268, 337, 380, 398, 409, 418, 424, 453, 472, 478, 500, 557, 575, 626, 709, 721, 739, 776, 792, 807, 819, 842, 877, 887, 949, 983, 1013, 1023, 1077, 1165, 1208, 1214, 1271, 1318, 1369, 1375, 1397, 1423, 1450, 1578, 1587, 1603, 1689, 1696, 1698, 1729, 1789, 1796, 1802, 1809, 1843, 1856, 1960, 1977, 1986, 2005, 2067, 2131, 2192, 2219, 2260, 2293, 2301, 2372, 2391, 2410, 2422, 2442, 2450, 2475, 2488, 2500, 2542, 2549, 2553, 2570, 2586, 2657, 2699, 2718, 2746, 2763, 2783, 2799, 2847, 2869, 2987, 3021, 3052, 3084, 3101, 3109, 3131, 3154, 3233, 3242, 3293, 3366, 3377, 3397, 3443, 3521, 3639, 3739, 3858, 3870, 3894, 3919, 3965, 4004, 4040, 4049, 4065, 4069, 4094, 4107, 4177, 4306, 4361, 4394, 4430, 4438, 4442, 4460, 4477, 4496, 4503, 4522, 4550, 4590, 4641, 4671, 4732, 4745, 4768, 4783, 4836], 'haemophilia': [43, 56, 1222, 1435, 1963, 2138, 2342, 2587, 2593, 2965, 3035, 3249, 4674, 4882, 4919], 'have': [44, 100, 158, 507, 588, 752, 912, 946, 1080, 1188, 1852, 1875, 1956, 1988, 2009, 2119, 2506, 2530, 2567, 2675, 2858, 2985, 3766, 3855, 3994], 'resulted': [45, 238, 2986, 4064], 'a': [47, 102, 110, 166, 229, 359, 369, 473, 527, 542, 572, 764, 808, 814, 837, 963, 978, 996, 1024, 1146, 1205, 1288, 1391, 1411, 1542, 1593, 1607, 1639, 1699, 1726, 1736, 1747, 1890, 2084, 2144, 2187, 2230, 2381, 2601, 2627, 2662, 2679, 2700, 2728, 2796, 2820, 3009, 3065, 3117, 3138, 3147, 3234, 3243, 3315, 3338, 3382, 3405, 3453, 3467, 3492, 3514, 3533, 3550, 3585, 3626, 3637, 3688, 3690, 3717, 3752, 3760, 3874, 3952, 3996, 4012, 4020, 4066, 4075, 4095, 4108, 4138, 4147, 4151, 4191, 4196, 4233, 4255, 4265, 4404, 4427, 4461, 4472, 4516, 4536, 4572, 4606, 4609, 4787, 4818, 4909], 'dramatic': [48], 'increase': [49], 'both': [51, 2958, 3059, 3524, 4023, 4230, 4370, 4688], 'longevity': [52], 'patients': [54, 151, 477, 587, 611, 1038, 1130, 1174, 1220, 1305, 1329, 1381, 1433, 1458, 1471, 1612, 1679, 1692, 1774, 1779, 1807, 1815, 1961, 2027, 2264, 2294, 2328, 2522, 2555, 2565, 2591, 2658, 2770, 2786, 2902, 2947, 3000, 3033, 3090, 3114, 3164, 3181, 3204, 3247, 3299, 3318, 3418, 3508, 3522, 3663, 3683, 3711, 3746, 3969, 4050, 4169, 4416, 4465, 4523, 4551, 4747, 4785, 4803, 4840, 4880], 'with': [55, 152, 209, 295, 440, 466, 515, 541, 749, 772, 813, 897, 908, 931, 1039, 1131, 1151, 1176, 1221, 1242, 1313, 1354, 1434, 1485, 1658, 1711, 1881, 1928, 1962, 1965, 2028, 2032, 2137, 2265, 2295, 2335, 2341, 2358, 2393, 2523, 2592, 2659, 2771, 2833, 2861, 2872, 2911, 2920, 2928, 2948, 2964, 2974, 2980, 2993, 3003, 3008, 3030, 3034, 3070, 3093, 3172, 3193, 3208, 3223, 3248, 3301, 3337, 3404, 3458, 3523, 3549, 3555, 3593, 3614, 3677, 3695, 3726, 3829, 3860, 3991, 4006, 4051, 4059, 4137, 4157, 4175, 4179, 4195, 4238, 4254, 4264, 4453, 4673, 4709, 4748, 4821, 4825, 4881, 4920], 'their': [58, 1158, 2467], 'quality': [59], 'life': [61], '75;': [63], '86;': [64], '77).': [65], 'However,': [66, 522, 637, 1170, 1374, 2172, 2428, 2689, 3097, 3241, 3413, 3745, 4795], 'use': [68, 976, 1159, 3495, 4002], 'coagulation': [70, 233, 296, 734, 1044, 1069, 1090, 1177, 1298, 2039, 2195, 2314, 2560, 2981, 3791, 4710, 4921], 'factor': [71, 234, 297, 735, 1045, 1070, 1091, 1114, 1178, 1299, 1440, 2040, 2196, 2232, 2315, 2561, 2982, 3792, 3853, 4689, 4711, 4922], 'concentrates': [72, 225, 736, 875, 900, 956, 1046, 1071, 1103, 1179, 1185, 1441, 1707, 2197, 2316, 4923], 'derived': [73, 655], 'from': [74, 176, 192, 934, 1218, 1493, 1545, 1552, 1613, 1680, 1740, 1758, 1940, 2792, 2933, 2968, 3042, 3478, 3759, 4381], 'pooled': [75, 457, 1297], 'donations': [76], 'thousands': [78], 'donors': [80, 451, 607, 889], 'introduced': [81, 1076], 'risk': [83, 1084, 1344, 1620, 1755, 2091, 2110, 2156, 2231], 'transmission': [85, 648, 858, 1086, 2058, 2094, 2112, 2159], 'viruses.': [87], 'Infections': [88], 'such': [89, 594, 999, 2509, 2554, 2807, 4651], 'human': [91], 'immunodeficency': [92], 'virus': [93, 98, 250, 267, 309, 357, 569, 684, 691, 695, 713, 762, 802, 1003, 1061, 1292, 1309, 1723, 1923, 1968, 2062, 2098, 2163, 2420, 2977, 3473, 4037, 4640], '(HIV)': [94], 'hepatitis': [96, 162, 206, 240, 248, 287, 350, 355, 564, 650, 665, 682, 689, 701, 728, 846, 924, 944, 987, 1001, 1021, 1030, 1051, 1088, 1107, 1192, 1228, 1258, 1269, 1333, 1365, 1468, 1475, 1496, 1500, 1508, 1586, 1721, 1882, 1921, 1966, 2018, 2053, 2060, 2087, 2096, 2161, 2202, 2395, 2418, 2585, 2891, 2975, 3471, 3975, 4053, 4310, 4638, 4822, 4827], 'C': [97, 163, 249, 323, 356, 565, 849, 925, 988, 1031, 1193, 1270, 1334, 1722, 1883, 1922, 1967, 2019, 2054, 2061, 2088, 2097, 2162, 2396, 2419, 2892, 2976, 3472, 4054, 4311, 4639, 4830], '(HCV)': [99, 251], 'had': [101, 304, 893, 1224, 1386, 1437, 1459, 1472, 1482, 3183, 3898, 4232, 4418], 'significant': [103, 573, 809, 2376, 2455, 4067, 4428, 4486], 'impact': [104], 'on': [105, 375, 916, 2014, 2521, 2582, 2943, 3500, 3599, 3873], 'mortality': [106, 113, 173, 191, 1738, 1938, 4764], 'haemophiliacs.': [108, 1745, 2443], 'In': [109, 830, 861, 1427, 1541, 1606, 1636, 1746, 2242, 2444, 3380, 3945, 4164, 4397, 4723], 'study': [111, 167, 532, 1213, 1413, 1429, 1544, 1568, 1608, 1638, 1748, 1792, 2694, 2730, 3051, 3121, 3245, 3869, 3947, 4100, 4167, 4213, 4498, 4514, 4539, 4808], 'amongst': [114, 623, 870, 890, 1743, 4799], 'haemophiliacs': [115, 175, 293, 336, 433, 534, 561, 625, 660, 738, 871, 1200, 1272, 1353, 1424, 1554, 1734, 1752, 1795, 1946, 1987, 2489, 2543, 2735, 3123, 3783, 3872, 3950, 4290], 'U.K.': [118, 157, 1751, 1943, 1993, 2580], 'between': [119, 1522, 1596, 1816, 2384], '1977': [120], '1991,': [122], 'AIDS': [123], 'was': [124, 179, 212, 276, 280, 469, 539, 714, 836, 868, 883, 1186, 1247, 1259, 1421, 1443, 1509, 1519, 1576, 1592, 1629, 1770, 1786, 1800, 1839, 2457, 2490, 2742, 2751, 2759, 3099, 3107, 3291, 3971, 4080, 4251, 4262, 4412, 4440, 4458, 4475, 4499, 4509, 4804, 4832], 'far': [126, 327], 'commonest': [128, 139, 329], 'cause': [129, 140, 283, 330], 'death,': [131], 'liver': [133, 177, 193, 333, 492, 518, 755, 920, 1197, 1322, 1357, 1417, 1448, 1478, 1489, 1535, 1548, 1572, 1685, 1694, 1741, 1760, 1798, 1984, 2217, 2267, 2298, 2377, 2389, 2406, 2440, 2486, 2515, 2602, 2646, 2913, 2950, 3022, 3026, 3057, 3075, 4218, 4668, 4725, 4761, 4781, 4816, 4848, 4887, 4902], 'disease': [134, 178, 334, 493, 519, 756, 921, 1198, 1418, 1449, 1536, 1742, 1761, 1985, 2218, 4737], 'ranked': [135], 'third': [138], 'death': [142, 169, 1757], '18).': [144, 1953], 'It': [145, 481, 1914, 4377, 4557, 4896], 'is': [146, 325, 358, 407, 513, 629, 639, 763, 929, 981, 1160, 1201, 1378, 1735, 2063, 2076, 2099, 2167, 2174, 2224, 2229, 2246, 2290, 2307, 2347, 2380, 2425, 2620, 2629, 2647, 2661, 2795, 2878, 2893, 2898, 2939, 3006, 3328, 3360, 3402, 3518, 3622, 3697, 3774, 3811, 3836, 4011, 4029, 4123, 4127, 4336, 4357, 4378, 4391, 4540, 4713, 4743, 4765, 4817, 4874, 4897], 'estimated': [147, 1630], 'that': [148, 172, 184, 278, 289, 485, 509, 536, 672, 886, 906, 1236, 1287, 1363, 1380, 1384, 1415, 1462, 1505, 1637, 1860, 1919, 2107, 2227, 2481, 2508, 2514, 2526, 2589, 2711, 2901, 3416, 3449, 3491, 3506, 3543, 3574, 3584, 3612, 3631, 3710, 3780, 4056, 4135, 4299, 4500, 4561, 4706, 4811, 4876, 4901], 'approximately': [149, 768, 1302, 3398], '3000': [150], 'bleeding': [153, 1040, 2029], 'disorders': [154, 1041, 2030], 'been': [159, 305, 365, 483, 526, 790, 805, 894, 947, 1189, 1388, 1854, 1876, 1917, 1958, 1989, 2431, 2614, 2635, 2676, 2817, 2859, 3642, 3856, 4297, 4705], 'exposed': [160, 306, 562, 1190, 2416, 4554], 'virus,': [164, 926, 989, 1194, 1884], 'certificates': [170], 'showed': [171, 1414, 1491, 2710, 3064, 4055, 4810], 'among': [174, 335, 1199], '16.7': [180], 'times': [181, 196, 3146, 3262, 3466], 'higher': [182, 197, 869, 1289, 1737, 1842, 3010, 3235, 3373, 4766], 'than': [183, 876, 1139, 2106, 2320, 2573, 3332, 4155, 4767, 4912], 'population,': [188], 'cancer': [194], '5.6': [195], '19).': [199, 1781], 'development': [201, 254, 1256, 1930, 2082, 2234, 2653, 3847, 3890, 3918, 3936, 4890], 'acute': [203, 785, 1018, 1311, 1332], 'non-A,': [204, 285, 1226], 'non-B': [205, 286, 1227], 'following': [207, 952, 1652, 2439, 3028], 'blood': [210, 436, 450, 579, 606, 653, 878, 888, 1098, 1281, 1320, 1768, 1824, 2033], 'products': [211, 437, 458, 580, 656, 1134, 1769, 1825], 'recognized': [213, 277, 3648], 'many': [214, 585, 793, 2969, 2999], 'years': [215, 1079, 1393, 1625, 1703, 1763, 1820, 2846, 4648], 'ago.': [216], 'Prior': [217], 'introduction': [220, 301, 954], 'heat': [222, 969], '1985,': [227], 'even': [228], 'single': [230], 'infusion': [231], 'concentrate': [235, 298, 1232, 1243, 1276, 2041, 2562, 2983, 3793, 4712], 'almost': [236, 1081, 4386], 'invariably': [237, 4081], '32;': [242], '45).': [243], 'Following': [244], 'identification': [245], 'an': [256, 693, 780, 913, 1017, 1715, 1790, 2064, 2121, 2351, 2686, 3019, 3425, 3501, 3667, 3899, 3972, 4757], 'immunoassay': [257], 'using': [258], 'cloned': [259], 'viral': [260, 387, 550, 1155, 2282, 3012, 3343, 3347, 3374, 3385, 3394, 3563, 3600, 3603, 4207, 4371, 4580, 4603], 'antigen': [261], 'detect': [263], 'antibody': [264, 315, 2127, 2960], 'against': [265, 664, 681, 688, 1050, 1106, 2086, 2178, 2201, 3852, 3961, 4276, 4325], 'serum': [269, 778, 1528, 1597, 2385, 2755, 3127, 3196, 3528, 3562, 3658, 4070, 4432, 4448], '(Choo': [270], 'et': [271], 'al,': [272], '1989;': [273], '46),': [274], 'it': [275, 787, 1377, 2173, 2228, 2245, 2254, 3773, 4295, 4335, 4366, 4644, 4675, 4873], 'HCV': [279, 510, 1866, 2862, 2992, 3342, 3538, 3556, 4206], 'principal': [282], 'majority': [291, 431, 1172, 1327], 'treated': [294, 895, 1175, 2031, 3089, 3113, 3300, 3912], 'before': [299, 1180, 2042, 3060, 4220, 4649], 'heat-treatment': [303, 1183], 'tested': [311, 1234], 'positive': [312, 2780, 2956, 3534], 'for': [313, 621, 642, 647, 703, 856, 1129, 1567, 1772, 1777, 2050, 2125, 2233, 2280, 2600, 2642, 2785, 2824, 2863, 2889, 2904, 2908, 2957, 3225, 3264, 3275, 3469, 3537, 3734, 3777, 3880, 3998, 4031, 4183, 4190, 4284, 4316, 4338, 4348, 4409, 4655, 4853, 4886, 4918], 'anti-HCV': [314, 1245, 2126, 2905, 2959], '54;': [317], '79;': [318], '12;': [319], '99;': [320], '95).': [321], 'Hepatitis': [322, 567, 760, 800, 1059], 'infection': [324, 465, 570, 593, 751, 867, 1007, 1340, 1880, 1924, 2997, 3038, 3474, 3554, 4039], 'chronic': [332, 491, 919, 1014, 1029, 1196, 1406, 1446, 1465, 1473, 1494, 1498, 1506, 1584, 1759, 1920, 1983, 2017, 2216, 2220, 2394, 2890, 3470, 4052, 4871], 'developed': [338, 627, 1225, 2736, 3958, 4619], 'countries,': [339], 'but': [340, 727, 851, 880, 990, 1016, 1143, 1775, 1808, 2253, 2360, 2739, 2867, 2906, 3032, 3504, 3572, 3730, 3805, 3819, 3906, 4121, 4643, 4862], 'other': [341, 1558, 2165, 2471, 2805, 2925, 2970, 3103, 3999], 'viruses': [342, 993, 4027, 4327, 4831], 'may': [343, 487, 675, 730, 1032, 1283, 1293, 1864, 1925, 2212, 2517, 2607, 2776, 2984, 3646, 3756, 3940, 4145, 4279, 4301, 4660, 4904], 'also': [344, 470, 685, 716, 1683, 1787, 1840, 1853, 1916, 1957, 2010, 2151, 2225, 2544, 2777, 2955, 3055, 3532, 4216, 4676, 4809, 4863], 'occasionally': [345], 'be': [346, 662, 676, 719, 731, 1048, 1066, 1294, 1632, 1926, 2045, 2104, 2152, 2199, 2271, 2369, 2519, 2547, 2595, 2608, 2844, 3364, 3476, 3498, 3510, 3547, 3578, 3597, 3618, 3634, 3647, 3680, 3700, 3724, 3732, 3832, 3929, 4282, 4302, 4559, 4629, 4646, 4661, 4754, 4908], 'responsible': [347], '(such': [348], 'B': [351, 568, 651, 683, 702, 847, 4828], 'D).': [353], 'single-stranded': [360], 'RNA': [361, 694, 803, 2283, 3564, 4026], 'flavivirus': [362, 765], 'which': [363, 696, 766, 994, 1215, 1682, 3054, 3871, 4016, 4578, 4613], 'has': [364, 482, 524, 612, 788, 804, 1028, 1915, 2430, 2613, 2634, 2816, 3641, 4296, 4529, 4704], 'further': [366, 2788, 3691, 3761, 4192], 'classified': [367], 'into': [368], 'series': [370], 'six': [372, 2732, 3295, 4801], 'major': [373], 'genotypes': [374, 468, 3557], 'basis': [377, 4347], 'variations': [379], 'non-structural': [382], 'NS-5': [383], 'region': [384, 4600], 'genome': [388, 4604], '84,': [390], '83).': [391], 'Genotypes': [392], '1,': [393, 3345], '2': [394, 3558], '3': [396, 538, 3256, 3393, 3671], 'predominate': [397], 'Northern': [399, 740], 'Europe': [400, 741], 'North': [402, 414], 'America,': [403], 'whereas': [404, 4259], 'type': [405, 416, 422, 537, 3392], '4': [406, 1261], 'encountered': [408], 'Middle': [411, 725], 'East': [412], 'Africa,': [415], '5': [417, 2845], 'South': [419], 'Africa': [420, 722], '6': [423, 1502, 2276, 3479, 3984, 4410, 4467, 4480], 'parts': [425], 'Far': [428], 'East.': [429], 'infected': [434, 439, 1389, 1964, 2860, 2973], 'through': [435, 652, 1089, 2164, 4889], 'types': [441], '1': [442, 512, 3567, 4200], 'or': [443, 601, 1004, 1656, 2183, 2331, 2625, 2811, 3036, 3072, 3267, 3559, 3589, 3602, 3737, 3840, 3891, 4008, 4181, 4246, 4829, 4893], '3,': [444, 3560], 'reflecting': [445], 'origin': [447], 'used': [452, 2349, 4315, 4495, 4589], 'manufacture': [455], '91;': [460, 3355], '42;': [461], '72;': [462], '80).': [463, 3312, 3412], 'Mixed': [464], 'several': [467, 950, 4326], 'documented': [471, 1687, 1788, 2120, 3108, 3124, 4476, 4833], 'small': [474, 4045], 'minority': [475, 810, 3316], 'these': [479, 834, 1093, 1886, 2712, 3043, 3378, 3575, 3806, 4344, 4615, 4625], 'studies.': [480], 'suggested': [484, 508, 1235, 1918, 4298], 'genotype': [486, 511, 2996, 3344, 3395, 3601, 4260], 'influence': [488, 915], 'progression': [489, 917, 1492, 1719, 2214], 'response': [495, 3067, 3237, 3340, 3359, 3407, 3552, 3669, 3893, 4154, 4236, 4474, 4574], 'interferon.': [497, 4556], 'Several': [498], 'studies': [499, 821, 835, 935, 1351, 1732, 2118, 2505, 3017, 3044, 4048], 'non-haemophilic': [501, 937, 2414, 2501, 2574], 'well': [503, 3081, 3757, 4379, 4510], 'haemophilic': [505, 1611, 2452, 2564, 4784], 'subjects': [506, 938, 2392, 2415, 2575, 4215], 'associated': [514, 540, 1927, 3007, 3336, 3403, 3548, 3973, 4253, 4263, 4436], 'more': [516, 1137, 2875, 4266], 'aggressive': [517], '91).': [521], 'this': [523, 852, 928, 1428, 1950, 2363, 2476, 2683, 3932, 4122, 4353, 4497], 'not': [525, 911, 991, 1054, 1063, 1367, 1510, 1565, 1948, 2247, 2473, 2529, 2715, 2752, 2917, 2931, 3596, 3617, 3665, 3685, 3714, 3723, 3775, 3883, 3924, 4281, 4358, 4420, 4552, 4714, 4728, 4753, 4859], 'consistent': [528, 930, 1727], 'finding,': [529], 'another': [531, 862], 'reported': [535, 775, 815, 948, 1855, 1959, 3857, 4786], 'worse': [543], 'prognosis': [544], '72).': [546], 'Genotype': [547, 4249], 'analysis': [548, 1676], 'load': [551, 3375, 3604, 4208], 'quantitation': [552], 'therefore': [554, 2325, 3361, 4280], 'useful': [555], 'tests': [556, 1359, 2146, 2269, 2915, 2952, 3024, 3077, 3576], 'evaluation': [559], 'virus.': [566, 2055, 2089, 4823], 'represented': [571], 'problem': [574, 1207], 'past': [577, 2989], 'when': [578], 'were': [581, 1233, 1396, 1464, 1550, 1563, 2511, 2714, 3039, 3251, 3878, 4091, 4170, 4209, 4488], 'first': [582, 1627, 1765, 3049], 'developed,': [583, 4584], 'older': [586], 'serological': [589, 1460], 'evidence': [590, 1444, 1461, 1645, 1661, 2226, 2308, 3414, 3624], 'previous': [592, 599], 'anti-HBs': [596], 'positivity': [597, 620, 2124, 4751], 'without': [598, 2597], 'vaccination,': [600], 'anti-HBc': [602], 'positivity.': [603], 'Screening': [604, 2767], 'vaccination': [609, 1105], 'virtually': [613], 'eliminated': [614, 1082], 'problem.': [616], 'prevalence': [618, 864, 882], 'HBsAg': [622], 'severe': [624], 'countries': [628, 794, 951], 'now': [630, 1119, 4541], '<': [631, 2129, 2498], '3%': [632, 2130], '28;': [634], '90;': [635], '53).': [636, 1709], 'there': [638, 1442, 1518, 1591, 2075, 2223, 2306, 2429, 2619, 2803, 3621, 3835, 3970], 'no': [640, 1520, 2077, 2940, 3269], 'room': [641], 'complacency,': [643], 'remains,': [657], 'all': [659, 1154, 1730, 1750, 2747, 4387, 4746], 'should': [661, 1047, 2044, 2150, 2198, 2270, 3475, 3497, 3577, 3595, 3616, 3633, 3679, 3722, 3731, 3831, 4752], 'vaccinated': [663, 1049, 2200], 'B,': [666], 'immunity': [668], 'monitored': [669, 4210], 'periodically': [670], 'so': [671], 'booster': [673], 'doses': [674], 'given': [677, 3767, 4413], 'if': [678, 1053, 2327, 2610, 2626, 2644, 2802, 2835, 3620, 3834], 'required.': [679], 'Vaccination': [680], 'confers': [686], 'protection': [687], 'D': [690, 729], '(HDV),': [692], 'requires': [697], 'presence': [699], 'its': [704], 'own': [705], 'replication.': [706], 'First': [707], 'identified': [708, 2615], 'Southern': [710], 'Europe,': [711], 'subsequently': [715, 4092], 'found': [717, 1577, 1801], 'endemic': [720], 'East,': [726], 'transmitted': [732, 1067, 1295], 'via': [733], 'America': [743], '76;': [745], '78;': [746], '47).': [747, 3795], 'Haemophiliacs': [748], 'HDV': [750], 'rapidly': [753], 'progressive': [754, 1416, 1447], '17;': [758, 2240], '48).': [759], 'G': [761, 801], 'shares': [767], '25%': [769], 'genomic': [770], 'homology': [771], 'HCV.': [773], 'Originally': [774], 'American': [781, 1791, 3609], 'surgeon': [782], 'who': [783, 892, 1026, 1042, 1223, 1330, 1436, 2037, 2697, 2953, 3136, 3165, 3182, 3250, 3272, 3712, 3747, 3896, 4243, 4417], 'contracted': [784], 'hepatitis,': [786, 2221, 4872], 'since': [789], 'isolated': [791], 'around': [795, 823], 'world': [797], '51).': [799], 'detected': [806, 841], 'haemophiliacs,': [812, 2800, 3053, 3771], 'incidence': [816, 1829, 2122, 3915], 'seropositivity': [818], 'most': [820, 2243, 2590, 3110, 3507], '15%': [824], '41;': [826], '93;': [827], '100;': [828], '33).': [829], 'only': [831, 1260, 1390, 2764, 2886, 3116, 3294, 3314, 4805, 4860], 'one': [832, 2445, 2690, 2765, 3946, 4398], 'case': [838, 4363], 'HGV-RNA': [840], 'absence': [844, 3389], 'infection,': [850, 1312, 1724], 'demonstrates': [853], 'independent': [857], '93).': [860], 'study,': [863, 2477, 4401], 'HGV': [866, 909], 'receiving': [872, 3951, 4229], 'non-virus': [873], 'inactivated': [874, 899], 'donors,': [879], 'similar': [884, 1543, 1675, 3066], 'those': [891, 992, 2036, 2848, 2870, 2927, 3417, 3895, 4228, 4242], 'exclusively': [896], 'virally': [898], '22).': [902], 'These': [903, 1133, 4089], 'reports': [904, 3844], 'suggest': [905], 'co-infection': [907, 1785], 'does': [910, 1008, 1062, 4727], 'adverse': [914, 1716], 'due': [922, 4112], 'conclusions': [932, 3927], 'drawn': [933, 3930], '61;': [940], '7).': [941], 'Outbreaks': [942], 'A': [945, 1002, 1022, 1052, 1108, 1211, 1408, 1674, 1870, 2203, 2206, 2839, 3357, 3867, 4330, 4512, 4771], 'subjected': [957], 'solvent/detergent': [959, 979], 'alone': [961, 2775, 3993, 4160, 4528], 'virucidal': [964, 1100], 'process,': [965], 'opposed': [967, 2287], '92;': [972], '58;': [973], '44).': [974], 'mixture': [980], 'effective': [982], 'inactivating': [984], 'HIV': [985, 1712, 2114, 2873, 3004, 3037, 4277, 4594, 4750], 'lack': [995], 'lipid': [997], 'envelope': [998], 'parvovirus.': [1005], 'Acute': [1006], 'not,': [1009], 'course,': [1011, 3689], 'result': [1012, 1368, 3232, 4731], 'disease,': [1015, 3823, 4321, 4669], 'episode': [1019], 'already': [1027, 1055, 3897], 'prove': [1033, 4906], 'fatal': [1034], '97).': [1036], 'All': [1037, 2026], 'receive': [1043], 'immune': [1056, 1862, 1893], '96).': [1058], 'E': [1060], 'appear': [1064, 4729], '59;': [1073], '103).': [1074], 'Measures': [1075], 'recent': [1078, 2504, 2691, 4399, 4772], 'concentrates;': [1092], 'include': [1094, 1898, 3341, 3553, 3820, 4858], 'screening': [1095, 2709, 2823, 4623], 'individual': [1097, 3502], 'donations,': [1099], 'B.': [1110, 1469, 2205], 'Recombinant': [1111], 'preparations': [1112], 'VIII': [1115, 3854, 4690], 'IX': [1117, 4692], 'available': [1120, 4567, 4654], 'regarded': [1123, 3579, 4662, 4755], 'choice': [1128], 'haemophilia.': [1132], 'much': [1136], 'expensive': [1138], 'conventional': [1140], 'plasma-derived': [1141], 'products,': [1142, 2034], 'they': [1144, 1463, 2527, 2836], 'offer': [1145, 4146], 'greater': [1147], 'margin': [1148], 'safety': [1150], 'regard': [1152, 2405], 'infections': [1156], 'certain': [1161], 'grow': [1163], 'considerably': [1164], 'next': [1167], 'few': [1168, 1392, 3118], 'years.': [1169], '1985': [1181], '(when': [1182], 'introduced)': [1187], 'likely': [1202, 2856, 3362, 4875], 'become': [1204, 3184, 4884], 'growing': [1206], 'future.': [1210], 'retrospective': [1212], 'stored': [1216], 'sera': [1217], '28': [1219], 'after': [1229, 1240, 1273, 1310, 1626, 1704, 1764, 1821, 2459, 2485, 2576, 3062, 3091, 3115, 3186, 3216, 3280, 3326, 3751, 3802, 4083, 4129, 4199, 4222, 4466, 4482, 4721, 4843], 'exposure': [1230, 1274, 1628, 1705, 1766, 1822, 2051, 2990], 'median': [1238, 1253], 'time': [1239, 1254, 1385, 1667, 2830, 2841], 'seroconversion': [1246], '11': [1248], 'weeks': [1249, 4185], '49).': [1251], 'weeks.': [1262], 'apparently': [1264], 'shorter': [1265], 'incubation': [1266], 'period': [1267, 1700, 3215, 3222], 'compared': [1277, 2496, 3303, 4237], 'recipients': [1279], 'transfusion': [1282], 'reflect': [1284, 4900], 'fact': [1286], 'inoculum': [1290], 'concentrate.': [1300], 'Only': [1301, 3202], '20%': [1303, 3399], 'will': [1306, 1335, 2366, 2930, 3319, 4628, 4645, 4883], 'eliminate': [1307, 1338], 'loss': [1314, 3150, 3173, 4454], 'detectable': [1316, 3152, 3175, 4456], 'HCV-RNA': [1317, 1850, 2909, 3011, 3153, 3197, 3206, 3290, 3653, 4439, 4457], '6;': [1324], '64).': [1325], 'develop': [1331, 2329], 'fail': [1336], 'at': [1343, 1383, 1451, 1647, 2273, 2685, 2744, 2827, 2923, 3276, 4403], 'developing': [1346], 'persistent': [1347, 1495, 1507, 1834, 1879, 3525], 'hepatitis.': [1348], 'Initial': [1349], 'clinical': [1350, 1660, 2693, 3740, 4656], 'persistently': [1355, 2296], 'abnormal': [1356, 1571, 2266, 2949, 3655], 'function': [1358, 1573, 2268, 2299, 2914, 2951, 3023, 3076], 'appeared': [1360, 3230], 'indicate': [1362], 'post-transfusion': [1364], 'would': [1366, 2404, 2843, 3509], 'overt': [1370], 'illness': [1371], '56).': [1373], 'retrospect': [1376], 'clear': [1379], 'studied': [1382], 'probably': [1387], 'beforehand': [1394], 'early': [1399, 2687, 2721], 'stages': [1400], 'natural': [1403, 4868], 'history': [1404, 4869], 'infection.': [1407, 2312, 4312, 4595], 'decade': [1409], 'later': [1410], 'histological': [1412, 1601, 3086], 'cirrhosis': [1420, 1483, 1688, 2660, 2929, 3350, 4892], 'common': [1422], '39).': [1426], '79': [1431], 'unselected': [1432], 'received': [1438, 2038, 4244], 'clotting': [1439], 'least': [1452, 1648, 2274, 3277], '17': [1453], '(21%).': [1454], 'None': [1455, 3159], 'carriers': [1466], 'Eight': [1470], 'active': [1474, 1499, 1585], 'proven': [1476], 'biopsy': [1479, 2407, 2441, 2487, 2516, 2552, 2603, 2643, 4219, 4835], 'nine': [1481, 4239, 4837], '(five': [1484], 'oesophageal': [1486, 2793], 'varices).': [1487], 'Serial': [1488], 'biopsies': [1490, 1549, 1580, 2449, 3058], 'within': [1501, 2186, 3670, 3983, 4119], 'years,': [1503], 'suggesting': [1504, 1859], 'benign': [1512], 'previously': [1514, 4419, 4524, 4553], 'thought.': [1515], 'Most': [1516, 2117, 2402], 'importantly,': [1517], 'relationship': [1521], 'degree': [1524], 'abnormality': [1526], 'transaminase': [1529, 1598, 1837, 2386, 3129, 3210, 3529, 3660], 'levels': [1530, 1599, 1838, 1851, 2387, 2674, 2774, 3130, 3211, 3530, 3565, 4079, 4204, 4452], 'severity': [1533], 'revealed': [1538], 'biopsy.': [1540, 1605], 'Germany,': [1546], '52': [1547], 'taken': [1551], '45': [1553, 2853, 3297], 'undergoing': [1555], 'orthopaedic': [1556], 'surgery': [1559, 2750], '82).': [1561], 'Patients': [1562, 2340, 2963], 'thus': [1564], 'selected': [1566], 'because': [1569, 2978, 3782], 'tests.': [1574], 'Cirrhosis': [1575], '12%': [1582], '17%,': [1588], 'again': [1590, 4252], 'poor': [1594, 2382, 3339, 3358, 4256], 'correlation': [1595, 2383], 'findings': [1602, 4090], '255': [1610], 'Royal': [1615], 'Free': [1616], 'Hospital': [1617], '(London),': [1618], 'hepatic': [1622, 1642], 'decompensation': [1623, 1643], '20': [1624, 1819, 4839], '10.8%': [1633], '90).': [1635], 'diagnosis': [1640, 1979, 2745], 'required': [1644, 2609, 4715], 'two': [1649, 3203], 'criteria:': [1653], 'ascites': [1654, 2332], '(clinical': [1655], 'radiological)': [1657], 'hypoalbuminaemia,': [1659], 'jaundice,': [1663], 'encephalopathy': [1664], 'prothrombin': [1666], 'prolongation': [1668], 'beyond': [1669], 'normal': [1671, 2297, 2912, 3209], 'laboratory': [1672], 'range.': [1673], '138': [1678], 'Sheffield,': [1681], 'included': [1684, 2474, 3056], 'biopsies,': [1686], '19%': [1690], 'failure': [1695, 1799, 3645], '9%': [1697], '22': [1702, 4415], 'Co-infection': [1710], 'clearly': [1713], 'exerts': [1714], 'effect': [1717, 1783], 'upon': [1718], 'observation': [1728], 'epidemiological': [1731], 'rate': [1739, 2484, 3238, 4790, 4798], 'HIV-positive': [1744, 1778, 3163, 3367], 'cumulative': [1754], '25': [1762, 4779], '1.4%': [1771], 'HIV-negative': [1773, 4769], '6.5%': [1776], '223': [1794], 'whom': [1797, 2423], '8/91': [1803], '(9%)': [1804], 'co-infected': [1806, 1845, 1857, 2871, 3002, 4289], 'none': [1810, 3305], '58': [1812], 'HCV+/': [1813], 'HIV−': [1814], '10': [1817], '28).': [1827], 'hepatomegaly,': [1831], 'splenomegaly,': [1832], 'elevation': [1835, 3526, 3656], 'significantly': [1841], 'group.': [1846], 'Higher': [1847], 'AST': [1848], 'patients,': [1858, 2072, 2453, 3368], 'HIV-induced': [1861], 'deficiency': [1863], 'promote': [1865], 'replication': [1867, 4018, 4372, 4581], '29).': [1869], 'number': [1871, 4021], 'extrahepatic': [1873], 'conditions': [1874, 1897], 'attributed': [1877, 4489], 'presumably': [1887], 'arise': [1888], 'consequence': [1891], 'complex': [1894], 'disease.': [1895, 2378, 3842], 'Such': [1896], 'arthritis,': [1899], 'lichen': [1900], 'planus,': [1901], 'glomerulonephritis,': [1902], 'keratoconjunctivitis': [1903], 'sicca,': [1904], 'porphyria': [1905], 'cutanea': [1906], 'tarda': [1907], 'cryoglobulinaemia': [1909], '21;': [1911], '67;': [1912], '70).': [1913], "non-Hodgkin's": [1932], 'lymphoma': [1933], '63;': [1935], '104),': [1936], 'although': [1937, 3772, 4074, 4360, 4763], 'data': [1939], 'complete': [1942, 2251, 3170], 'population': [1944], 'do': [1947, 2528, 2916, 3664, 3684, 3713, 3923], 'support': [1949, 4708], 'hypothesis': [1951], 'Antiphosholipid': [1954], 'antibodies': [1955, 2532, 2810, 3850, 3939, 3959, 3979], '5).': [1970], 'Guidelines': [1971], 'relating': [1972], 'specific': [1974, 3244], 'issues': [1975], 'involved': [1976, 2191], 'management': [1981, 2015, 2070, 2412, 2583, 2945], 'published': [1990, 2011], 'Haemophilia': [1994], 'Centre': [1995], "Directors'": [1996], 'Organization': [1997], '71).': [1999, 2605, 2882, 3356], 'National': [2001, 3438], 'Institutes': [2002, 3439], 'Health': [2004, 3441], 'United': [2007, 3445], 'States': [2008, 3446], 'guidelines': [2013, 2581, 3610, 3708], '62;': [2021], 'NIH': [2022, 3707], 'Consensus': [2023, 3488], 'Conference,': [2024], '1997).': [2025], 'particularly': [2035, 2073, 2292, 2801, 4852], '1986,': [2043], 'traced': [2046], 'offered': [2048, 2153], 'testing': [2049, 2279], 'Counselling': [2056], 'about': [2057, 2433, 2622, 3931], 'important': [2065, 3933, 4898], 'aspect': [2066], 'overall': [2069], 'immediate': [2078], 'prospect': [2079, 4149], 'vaccine': [2085], 'sexual': [2093, 2133, 2148], 'low': [2100, 2169, 3383, 3561], 'appears': [2102, 4367], 'less': [2105, 2318, 2868], '102).': [2116], 'long-term': [2132, 4268, 4741], 'partners': [2134, 2149], 'people': [2136, 2357, 4672], '13;': [2140], '35;': [2141], '11).': [2142], 'If': [2143, 3662, 3682], 'positive,': [2147], 'testing.': [2154], 'intrafamilial': [2158], 'routes': [2166], 'extremely': [2168], '10).': [2171], 'prudent': [2175], 'advise': [2177, 2250, 2258, 3709], 'sharing': [2180], 'razors': [2182], 'toothbrushes,': [2184], 'etc.,': [2185], 'family.': [2188], 'Family': [2189], 'members': [2190], 'administration': [2193, 2558, 3778], 'sustained': [2207, 3236, 3324, 3515, 4152, 4234, 4257, 4473], 'high': [2208, 3346], 'intake': [2209, 3629, 3640], 'ethanol': [2211], 'hasten': [2213], 'hepatocellular': [2236, 2655, 2737, 4894], 'carcinoma': [2237, 2656], '98;': [2239], '27).': [2241], 'cases': [2244, 2472, 2748, 3886], 'necessary': [2248, 4744], 'abstinence,': [2252], 'seems': [2255], 'sensible': [2256], 'moderation': [2259], 'alcohol': [2261, 3628], 'consumption.': [2262], 'HCV-positive': [2263], 'reviewed': [2272], 'every': [2275], 'months.': [2277, 3119], 'PCR': [2278, 3535], 'circulating': [2281, 3652], '(preferably': [2284], 'quantitative': [2285], 'qualitative)': [2289], 'required,': [2291], 'tests,': [2300], 'order': [2302, 2493], 'establish': [2304], 'whether': [2305], 'persistence': [2310, 3650], 'High-purity': [2313], 'contain': [2317], 'sodium': [2319], 'intermediate-purity': [2321], 'ones,': [2322], 'preferable': [2326], 'oedema': [2330], 'requiring': [2333], 'diuretics': [2336], 'albumin': [2338], 'infusions.': [2339], 'often': [2343, 2879, 3785], 'require': [2344], 'analgesics.': [2345], 'Paracetamol': [2346], 'customarily': [2348], 'analgesic': [2352], 'instead': [2353], 'aspirin': [2355], 'dosage': [2361], 'hepatotoxic': [2364], 'drug': [2365, 4390], 'need': [2367, 2545, 2641, 2918], 'strictly': [2370], 'controlled': [2371, 4400], 'setting': [2374], 'There': [2379, 2897, 2938], 'histology': [2390, 3027], '39;': [2398], '82;': [2399], '2;': [2400], '40).': [2401], 'hepatologists': [2403], 'essential': [2409], 'being': [2426, 2630, 4583, 4618], 'considered.': [2427, 2631], 'concern': [2432], 'possibility': [2435], 'haemorrhagic': [2437], 'complications': [2438], 'survey': [2446, 4774], '126': [2448], '115': [2451], 'clinically': [2454], 'haemorrhage': [2456], 'observed': [2458, 3100, 3292, 4441, 4459], '12.5%': [2460], 'procedures': [2463], '4).': [2465], 'From': [2466], 'personal': [2468], 'knowledge': [2469], 'authors': [2479], 'concluded': [2480], 'fatality': [2483], '1%,': [2495], '0.01%': [2499], 'subjects.': [2502, 4770], 'More': [2503, 4293], 'indicated': [2507], 'fears': [2510], 'unfounded': [2512], 'generally': [2518], 'performed': [2520], 'provided': [2525, 4530], 'inhibitory': [2531, 2809, 3849], '1;': [2534], '101;': [2535], '52).': [2536, 3866], 'costs': [2538], 'procedure': [2541], 'borne': [2548], 'mind': [2550], 'inevitably': [2556], 'involves': [2557], 'usually': [2566, 3807, 4501], 'stay': [2569], 'hospital': [2571], 'longer': [2572], 'procedure.': [2578], 'conclude': [2588], 'can': [2594], 'managed': [2596], 'necessity': [2599], 'Biopsy': [2606], 'focal': [2611], 'lesion': [2612], 'ultrasound,': [2617], 'where': [2618, 2874], 'doubt': [2621], 'diagnosis,': [2624], 'transplant': [2628], 'Laparascopic': [2632], 'inspection': [2633], 'advocated': [2636, 2677, 2818], 'some,': [2638], 'avoiding': [2639], 'obviously': [2648], 'cirrhotic': [2649, 2769], '37).': [2651], 'well-recognized': [2663], 'risk,': [2664], 'periodic': [2666], 'ultrasound': [2667, 2705], 'examinations': [2668, 2713], 'determination': [2670], 'alpha': [2672, 2707, 2756], 'fetoprotein': [2673, 2708, 2757], 'way': [2680, 2821], 'detecting': [2682], 'complication': [2684, 2798], 'stage.': [2688], 'large': [2692, 3015], 'haemophilacs': [2696], 'enrolled': [2698], 'programme': [2701], 'annual': [2703], 'abdominal': [2704], 'sufficiently': [2716], 'sensitive': [2717], 'picking': [2719], 'up': [2720, 3226, 3274, 4060, 4189], 'signs': [2722], 'malignancy': [2724, 4861], '94).': [2726], 'During': [2727], '2-year': [2729], 'period,': [2731], '385': [2734], 'carcinoma,': [2738], 'tumour': [2741], 'multicentric': [2743], 'feasible.': [2753], 'level': [2758], '>': [2760, 2864], '400': [2761], 'ng/ml': [2762], 'case.': [2766], 'alpha-feto': [2772], 'protein': [2773], 'yield': [2778, 4571], 'false': [2779], 'results,': [2781], 'resulting': [2782], 'anxiety': [2784], 'unnecessary': [2789], 'investigations.': [2790], 'Bleeding': [2791], 'varices': [2794, 2825], 'serious': [2797, 3838], 'problems': [2806], 'HIV-associated': [2812], 'thrombocytopenia.': [2813], 'Periodic': [2814], 'endoscopy': [2815], 'same': [2829, 3728], 'permitting': [2831], 'sclerotherapy': [2834], 'detected.': [2838], 'suitable': [2840, 4283], 'interval': [2842], 'over': [2849], 'age': [2851, 3353], '(who': [2854], '30': [2865], 'years),': [2866], 'rapid': [2876], 'progress': [2877], 'seen': [2880, 3365, 3800, 4082, 4128], 'At': [2883], 'present': [2884], 'licensed': [2887, 3776, 4030, 4337], 'therapy': [2888, 3676, 3736, 3862, 4104], 'cytokine,': [2895], 'α-interferon.': [2896], 'agreement': [2900, 2942], 'seropositive': [2903], 'negative': [2907, 3207, 4855], 'interferon': [2921, 3094, 3142, 3190, 3224, 3409, 3430, 3459, 3496, 3594, 3615, 3678, 3696, 3721, 3755, 3768, 3830, 3861, 3877, 3981, 3992, 4007, 4141, 4176, 4245, 4423, 4519, 4527], 'and,': [2922], 'extreme,': [2926], 'benefit': [2932, 3702, 3758, 4305], '71;': [2936], '62).': [2937, 3486], 'HCV-RNA.': [2962, 3176], 'different': [2967], 'groups': [2972], 'repeated': [2988], 'resultant': [2994], 'mixed': [2995], '(which': [3005], 'load).': [3013], 'Two': [3014], 'randomized': [3016, 3050, 4097], 'demonstrated': [3018], 'improvement': [3020, 3071, 3083], 'interferon,': [3031, 3069, 3302, 3322, 3963], 'specifically': [3040], 'excluded': [3041], '20;': [3046], '25).': [3047], 'treatment,': [3063, 3283, 3675, 3804], 'normalization': [3073, 3125, 3284], 'during': [3078, 3212, 3749, 4211], 'appearance': [3087], '55).': [3096], 'studies,': [3104], 'biochemical': [3105], 'relapse': [3106, 3434, 3748], 'Another': [3120], 'alanine': [3128, 3659, 4071, 4433, 4449], 'eight': [3132], '29': [3134], '(28%)': [3135], 'completed': [3137, 3166], '6-month': [3139], 'course': [3140, 3168, 3188, 3428, 3455, 3692, 3719, 3753, 3762, 3875], '(3': [3143, 3460], 'MU': [3144], 'three': [3145, 3261, 3465, 3966], 'week),': [3148], 'seven': [3155, 3180], '(24%)': [3156], '36).': [3158], 'five': [3162], 'achieved': [3169], 'remission,': [3171], 'Five': [3177], 'nonviraemic': [3185], 'relapsed,': [3192], 'reappearance': [3194], 'elevated': [3199], 'ALT': [3200, 3286], 'levels.': [3201, 3661], 'remained': [3205], 'follow-up': [3214, 3750, 4198], 'treatment.': [3217, 3988, 4484], 'Extension': [3218], '12': [3228, 3265, 3278, 3482], 'months': [3229, 3266, 3279, 3480, 3483, 3672, 3985, 4411, 4468, 4481, 4842], '30).': [3240], 'randomly': [3252, 4171], 'assigned': [3253, 4172], 'either': [3255, 4003, 4158, 4826], 'million': [3257, 3461, 3568], 'units': [3258, 3462], 'interferon-α2b': [3260], 'weekly': [3263], 'therapy,': [3270, 4914], 'followed': [3273, 4188], 'cessation': [3281], 'clearance': [3288], '(13%)': [3298, 3949], '50': [3308], 'untreated': [3309], 'controls': [3310], 'Thus': [3313], 'respond': [3320, 3422, 3686, 3715], 'remission': [3325], 'exception': [3330], 'rather': [3331], 'rule.': [3334], 'Factors': [3335], 'load,': [3348, 3386], 'established': [3349], 'increasing': [3352, 4877], 'virtue': [3370], '(HCV-RNA)': [3376], 'patients.': [3379, 4445, 4856], 'contrast,': [3381, 4724], 'initial': [3384, 3426, 3668], 'younger': [3387], 'age,': [3388], 'cirrhosis,': [3391], '(encountered': [3396], 'patients)': [3401], 'better': [3406, 4148], '36;': [3411], 'suggests': [3415, 4134], 'fortunate': [3419], 'enough': [3420], 'favourably': [3423], '12-month': [3427], 'unlikely': [3432, 3511, 3698], '60).': [3436], '(NIH)': [3442], 'recently': [3447], 'recommended': [3448, 3520], 'length': [3451], 'standard': [3454, 3718, 3953], 'interferon-α': [3464], 'week)': [3468], 'increased': [3477], '68;': [3485], 'Group': [3489], 'advised': [3490, 3573], 'decision': [3493, 3586], 'made': [3499], 'basis,': [3503], 'acknowledged': [3505], 'experience': [3513, 4703], 'response.': [3516, 4269], 'Treatment': [3517, 3644, 3828], 'primarily': [3519, 4314], 'test': [3536], 'RNA.': [3539], 'group': [3541, 3913, 3922], 'recognizes': [3542], 'factors': [3544], 'known': [3545], 'favourable': [3551, 4267], '(<': [3566], 'copies': [3569], 'per': [3570], 'ml),': [3571], 'research': [3581], 'tools': [3582], 'treat': [3588], 'withhold': [3591], 'based': [3598], '50;': [3606], '68).': [3607], 'recommend': [3611], 'initiated': [3619], 'current': [3623], 'heavy': [3627], 'deferred': [3635], 'until': [3636], 'reduction': [3638], 'achieved.': [3643], 'show': [3666], 'starting': [3674, 3803], 'discontinued.': [3681], '3).': [3704, 3764], 'Accordingly,': [3705], 'retreated': [3725], 'regimen,': [3729], 'considered': [3733], 'combination': [3735, 4005, 4139, 4178, 4517, 4549], 'enrolment': [3738], 'trials': [3741], 'new': [3743, 3888], 'products.': [3744], 'Some': [3765], 'intravenously': [3769], 'route,': [3781], 'giving': [3786], 'themselves': [3787], 'regular': [3788], 'infusions': [3789], 'Flu-like': [3796], 'symptoms': [3797], 'commonly': [3799], 'soon': [3801], 'disappear': [3808], 'continued.': [3812], 'Serious': [3813], 'side-effects': [3814, 4487], 'fortunately': [3816], 'very': [3817], 'rare,': [3818], 'autoimmune': [3821, 3841], 'thyroid': [3822], 'depression,': [3824], 'cardiac': [3826], 'failure.': [3827, 3944], 'withheld': [3833], 'pre-existing': [3837], 'depression': [3839], 'Case': [3843], 'directed': [3851, 3960], 'association': [3859], '14;': [3864], '88;': [3865], 'prospective': [3868], 'screened': [3879], 'inhibitors': [3881, 4588], 'did': [3882], 'reveal': [3884], 'any': [3885, 4650], 'inhibitor': [3889, 3900, 3917], 'anamnestic': [3892], 'prior': [3901], '65),': [3905], 'modest': [3908], 'size': [3909], 'control': [3921], 'permit': [3925], 'definitive': [3926], 'issue.': [3934], 'anti-interferon': [3938], 'lead': [3941], '5/13': [3948], 'dose': [3954, 4405, 4494], 'recombinant': [3956], 'interferon-α2a': [3957], '‘breakthrough’': [3974], '38).': [3977], 'disappeared': [3982], 'stopping': [3987, 4084, 4130, 4223, 4483], 'Disappointing': [3989], 'results': [3990, 4106, 4532], 'prompted': [3995], 'search': [3997], 'agents': [4000, 4231, 4577, 4612, 4627, 4652], 'alone.': [4009, 4248], 'Ribavirin': [4010, 4103, 4270], 'purine': [4013], 'nucleoside': [4014], 'analogue': [4015], 'inhibits': [4017], 'DNA': [4024], 'respiratory': [4035], 'syncytial': [4036], '(RSV)': [4038], 'children': [4041], '69).': [4043], 'Early': [4044], 'uncontrolled': [4047], 'oral': [4057, 4143], '1200': [4062], 'mg/d': [4063, 4408], 'fall': [4068, 4429, 4437], 'aminotransferase': [4072, 4203], 'levels,': [4073], 'rise': [4076], 'pre-treatment': [4078], '73;': [4087], '26).': [4088], 'confirmed': [4093], 'larger': [4096, 4537], 'placebo-controlled': [4099, 4538], '24).': [4102], 'frequently': [4105], 'mild': [4109], 'haemolytic': [4110], 'anaemia': [4111], 'accumulation': [4115], 'ribavirin': [4117, 4144, 4180], 'triphosphate': [4118], 'erythrocytes,': [4120], 'reversible': [4124], 'reticulocytosis': [4126], 'therapy.': [4131, 4926], 'Recent': [4132], 'work': [4133], 'virological': [4153, 4235], 'agent': [4159], '81;': [4162], '74).': [4163], 'latter': [4166], '100': [4168], 'placebo': [4182, 4247], '24': [4184, 4193], 'then': [4187], 'weeks,': [4194], 'final': [4197], 'year.': [4201], 'Serum': [4202], 'underwent': [4217], 'treatment;': [4224], '18': [4225], '(36%)': [4226], '(18%)': [4240], '1b': [4250], 'response,': [4258], '3a': [4261], 'antagonizes': [4271], 'activity': [4273, 4324], 'zidovudine': [4275], 'some': [4288, 4304, 4647], '8).': [4292], 'recently,': [4294], 'amantadine': [4300, 4322, 4402, 4521], 'Although': [4313, 4740], "Parkinson's": [4320], 'exhibits': [4323], 'including': [4328], 'influenza': [4329, 4365], 'herpes': [4332], 'zoster': [4333], 'prophylaxis': [4342], 'infections.': [4345], 'antiviral': [4350, 4563], 'action': [4351], 'water-soluble': [4354], 'tricyclic': [4355], 'amine': [4356], 'understood,': [4359], 'inhibit': [4369, 4579, 4614], 'encapsulation': [4374], '85).': [4376], 'absorbed': [4380], 'gastrointestinal': [4383], 'tract,': [4384], 'excreted,': [4392], 'unchanged,': [4393], 'urine.': [4396], '200': [4407], 'responded': [4421], '87).': [4425], 'Overall,': [4426], 'aminotransaminase': [4434, 4450], '14': [4443], '(64%)': [4444], 'Normalization': [4446], '(ALT)': [4451], 'quarter': [4462], '(27%)': [4463], '18%': [4478], '(4/22)': [4479], 'No': [4485], 'drug.': [4492], 'employed': [4502], 'influenza,': [4507], 'tolerated.': [4511], 'pilot': [4513], 'unresponsive': [4525], 'encouraging': [4531], '31),': [4534], 'underway': [4542], 'evaluate': [4544], 'efficacy': [4546], 'must': [4558], 'conceded': [4560], 'options': [4565], 'currently': [4566], 'limited': [4569], 'disappointing': [4573], 'rate.': [4575], 'Antiviral': [4576], 'analogous': [4585], 'protease': [4587, 4607], 'For': [4596], 'example,': [4597], 'NS-3': [4599], 'encodes': [4605], 'helicase,': [4610], 'enzymes': [4616], '89).': [4621], 'novel': [4626], 'greatly': [4630], 'facilitated': [4631], 'ability': [4634], 'culture': [4636], 'vitro,': [4642], 'trials.': [4657], 'Liver': [4658], 'transplantation': [4659, 4726, 4762, 4849, 4888, 4903], 'ultimate': [4665], 'offers': [4677], 'additional': [4679], 'bonus': [4680], 'curing': [4682], 'underlying': [4684], 'haemostatic': [4685, 4707], 'defect': [4686], 'synthesized': [4694], 'hepatocytes': [4696], '9;': [4698], '66;': [4699], '23).': [4700], 'little': [4717], '48': [4719], 'h': [4720], 'surgery.': [4722], 'correction': [4733], 'von': [4735], "Willebrand's": [4736], '57).': [4739], 'immunosuppression': [4742], 'absolute': [4758], 'contraindication': [4759], 'world-wide': [4773], 'outcome': [4777], 'orthotopic': [4780], 'transplants': [4782], '3-year': [4788], 'survival': [4789, 4797], '83%': [4792], '34).': [4794], 'HIV-infected': [4802], '23%.': [4806], 're-infection': [4812], 'transplanted': [4815], 'frequent': [4819], 'occurrence': [4820], 'Re-infection': [4824], '9': [4841], 'operation.': [4845], 'Results': [4846], 'encouraging,': [4851], 'anti-HIV': [4854], 'Indications': [4857], 'end-stage': [4864], 'cirrhosis.': [4865], 'Given': [4866], 'numbers': [4878], 'candidates': [4885], 'carcinoma.': [4895], 'actually': [4905], 'cheaper': [4910], 'option': [4911], 'conservative': [4913], 'involving': [4915], 'continued': [4916], 'anti-viral': [4925]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2058302094', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-09T07:51:05.041357', 'created_date': '2016-06-24'}