The Inner Nuclear Membrane Protein Lamin B Receptor Forms Distinct Microdomains and Links Epigenetically Marked Chromatin to the Nuclear Envelope

Name: Work Video:
Duration: 3 min 30 s
Dimitra Makatsori; Niki Kourmouli; Hara Polioudaki; Leonard D. Shultz; Kelvin Mclean; Panayiotis A. Theodoropoulos; Prim B. Singh; Spyros D. Georgatos
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460, 482, 517, 593, 706, 716, 868, 878, 1027, 1261, 1421, 1472, 1539, 1769, 1783, 1930, 2190, 2241, 2348, 2504, 2520, 2540, 2566, 2643, 2701, 2758, 2772, 2885, 2894, 3018, 3460, 3465, 3479, 3483, 3497, 3502, 3535], 'the': [11, 15, 93, 97, 172, 175, 185, 301, 440, 461, 483, 508, 518, 521, 590, 594, 605, 608, 661, 836, 844, 850, 869, 1029, 1223, 1227, 1295, 1359, 1500, 1530, 1613, 1616, 1668, 1777, 1784, 1850, 1871, 1878, 1909, 2130, 2135, 2139, 2191, 2261, 2290, 2293, 2303, 2324, 2332, 2335, 2410, 2475, 2493, 2496, 2509, 2515, 2521, 2526, 2532, 2546, 2569, 2580, 2586, 2594, 2620, 2625, 2722, 2731, 2734, 2744, 2750, 2770, 2819, 2827, 2831, 2849, 2868, 2873, 2881, 2974, 2991, 3060, 3342, 3383, 3389, 3396, 3408, 3447, 3456, 3531, 3589, 3625, 3656, 3666, 3701, 3716, 3739, 3773, 3851, 3877, 3902, 3905, 3914, 3923, 3942, 3952, 3959, 3962, 4004, 4009, 4079, 4094, 4124, 4132, 4219], 'N-terminal': [12, 94, 557, 587, 1015, 1030, 2192, 3943], 'domain': [13, 95, 1016, 2193, 3399, 3944], 'inner': [16, 98, 186, 484, 549, 870, 2131], 'nuclear': [17, 53, 80, 99, 135, 162, 187, 302, 310, 322, 332, 485, 550, 752, 871, 1229, 1621, 1997, 2132, 2325, 2339, 3614, 4010], 'membrane': [18, 62, 100, 144, 188, 486, 551, 2133], 'protein': [19, 101, 314, 552, 829, 1724, 2188, 2259, 2736, 3605, 3778, 3954, 4119], 'lamin': [20, 102, 328, 522, 3055, 3615], 'B': [21, 103, 329, 523, 3056, 3616, 3643, 4017, 4069], 'receptor.': [22, 104], 'Mass': [23, 105], 'spectrometric': [24, 106, 2875], 'analysis': [25, 107], 'reveals': [26, 108], 'that': [27, 109, 404, 426, 450, 510, 601, 882, 902, 2253, 2300, 2517, 2833, 3019, 3262, 3466, 3519, 3546, 3552, 3565, 3599, 3673, 3951, 4205], 'LBR-associated': [28, 110, 854, 898, 2745, 3394, 3547], 'particles': [29, 111, 2046, 2203, 2242, 3259, 4148], 'contain': [30, 112, 3549], 'complex': [31, 113, 1910, 2792, 2839], 'patterns': [32, 114], 'methylated/acetylated': [34, 116], 'histones': [35, 117, 899, 1899, 2107, 2152, 2726, 2788, 2832], 'and': [36, 50, 79, 118, 132, 161, 178, 295, 363, 435, 565, 596, 607, 672, 798, 849, 886, 900, 913, 937, 960, 1034, 1041, 1112, 1117, 1129, 1165, 1264, 1280, 1345, 1371, 1379, 1425, 1429, 1451, 1459, 1467, 1515, 1527, 1533, 1603, 1633, 1651, 1661, 1679, 1692, 1747, 1758, 1787, 1836, 1873, 1913, 1924, 1956, 1999, 2026, 2043, 2113, 2134, 2153, 2183, 2207, 2266, 2460, 2531, 2585, 2596, 2605, 2624, 2640, 2654, 2699, 2716, 2766, 2768, 2795, 2812, 2842, 2864, 2892, 2920, 2930, 2938, 2954, 2981, 2999, 3025, 3031, 3048, 3112, 3235, 3378, 3402, 3416, 3430, 3439, 3453, 3511, 3558, 3575, 3611, 3636, 3663, 3678, 3731, 3768, 3782, 3799, 3839, 3844, 3855, 3882, 3889, 3990, 3998, 4015, 4022, 4024, 4030, 4071, 4090, 4118, 4137, 4173, 4190, 4210], 'are': [37, 119, 602, 843, 2466, 2599, 2630, 2967, 3010, 3063, 3857], 'devoid': [38, 120, 1995], '"euchromatic"': [40, 122], 'epigenetic': [41, 123, 406], 'marks.': [42, 124], 'LBR': [43, 125, 545, 694, 715, 848, 885, 903, 967, 1007, 1036, 1678, 1686, 1905, 2160, 2195, 2217, 2297, 2458, 2486, 2501, 2694, 2797, 2811, 2844, 2957, 2988, 3256, 3510, 3532, 3576, 3601, 3610, 3623, 3677, 3682, 3697, 3744, 3946, 4037, 4058, 4073, 4085, 4116, 4171, 4180, 4220], 'binds': [44, 126], 'heterochromatin': [45, 127, 168, 313, 335, 828, 866, 907, 1942, 2006, 2144, 3573], 'as': [46, 128, 908, 1141, 1414, 1698, 1774, 2393, 2403, 2407, 2612, 3006, 3011, 3064, 3077, 3082, 3180, 4076, 4107], 'a': [47, 74, 129, 156, 180, 288, 547, 555, 566, 666, 703, 909, 1563, 1626, 2002, 2100, 2163, 2185, 2255, 2306, 2657, 2705, 2791, 2838, 3253, 3470, 3480, 3484, 3498, 3503, 3536, 3604, 3776, 4127, 4138, 4202, 4212], 'higher': [48, 130, 910, 3769, 4088], 'oligomer': [49, 131], 'forms': [51, 133, 3741], 'distinct': [52, 134], 'envelope': [54, 136, 303, 333], 'microdomains': [55, 137, 3957], 'in': [56, 67, 73, 138, 149, 155, 171, 514, 675, 700, 723, 754, 835, 840, 897, 925, 946, 1024, 1194, 1222, 1234, 1274, 1311, 1386, 1446, 1464, 1507, 1562, 1593, 1682, 1700, 1727, 1898, 1940, 2059, 2121, 2178, 2260, 2394, 2404, 2474, 2609, 2633, 2656, 2710, 2725, 2761, 2805, 2830, 2848, 2900, 3012, 3021, 3065, 3252, 3347, 3355, 3365, 3388, 3412, 3428, 3446, 3530, 3567, 3580, 3588, 3624, 3693, 3700, 3724, 3736, 3753, 3850, 3938, 3948, 4059, 4078, 4177, 4182, 4201], 'vivo.': [57, 139], 'The': [58, 140, 586, 890, 1057, 1298, 1417, 1441, 1558, 1642, 1722, 2237, 2454, 2490, 2591, 2647, 2949, 2961, 3008, 3619, 3846, 3864, 3916, 4121], 'organization': [59, 141, 2262, 4056, 4181], 'these': [61, 143, 444, 747, 858, 2860, 3652, 4197], 'assemblies': [63, 145], 'is': [64, 146, 169, 361, 400, 423, 431, 451, 520, 546, 673, 2248, 2389, 2556, 2959, 2994, 3463, 3553, 3569, 3683, 3876, 3899, 3911, 3927, 4157], 'affected': [65, 147], 'significantly': [66, 148, 2105], 'heterozygous': [68, 150], 'ic': [69, 151], '(ichthyosis)': [70, 152], 'mutants,': [71, 153], 'resulting': [72, 154, 1228], 'variety': [75, 157], 'structural': [77, 159], 'abnormalities': [78, 160], 'defects.': [81, 163], 'IntroductionA': [164], 'significant': [165], 'proportion': [166], 'localized': [170], 'periphery': [173, 2326, 4011], 'cell': [176], 'nucleus': [177, 4134], 'maintains': [179], 'close': [181], 'spatial': [182, 285], 'association': [183, 286, 2295, 3574], 'with': [184, 411, 702, 827, 884, 905, 1181, 1216, 1409, 1504, 1511, 1517, 1529, 1587, 1612, 1620, 1648, 1653, 1671, 1798, 1809, 1815, 1864, 1908, 1934, 1953, 1962, 2047, 2162, 2227, 2250, 2298, 2302, 2312, 2321, 2368, 2427, 2433, 2443, 2483, 2568, 2651, 2729, 2790, 2835, 2924, 3043, 3058, 3341, 3374, 3508, 3514, 3572, 3607, 3668, 3680, 3706, 3871, 3892, 3897, 3908, 3922, 3970, 4012, 4064, 4113, 4144], '(1Carvalho': [189], 'C.': [190, 196, 731, 978, 1150, 1542, 1707, 2677], 'Pereira': [191], 'H.M.': [192], 'Ferreira': [193], 'J.': [194, 340, 351, 528, 575, 619, 638, 645, 729, 737, 765, 782, 976, 984, 994, 998, 1148, 1156, 1170, 1476, 1547, 1705, 1713, 1969, 2278, 2675, 2683, 3273], 'Pina': [195], 'Mendonca': [197], 'D.': [198, 764, 2016, 2028], 'Rosa': [199], 'A.C.': [200], 'Carmo-Fonseca': [201], 'M.': [202, 2273], 'Mol.': [203], 'Biol.': [204, 242, 275, 375, 577, 620, 646, 767, 783, 1172, 1549, 2075, 2280], 'Cell.': [205], '2001;': [206, 276, 341, 354, 818], '12:': [207], '3563-3572Crossref': [208], 'PubMed': [209, 228, 251, 264, 279, 344, 357, 379, 394, 472, 502, 540, 581, 630, 656, 688, 741, 771, 793, 821, 988, 1104, 1160, 1176, 1553, 1717, 1975, 1988, 2079, 2284, 2687, 3207, 3284, 3310, 3327], 'Scopus': [210, 229, 252, 265, 280, 345, 380, 395, 473, 503, 541, 582, 631, 657, 689, 742, 772, 794, 822, 989, 1002, 1105, 1161, 1177, 1554, 1718, 1976, 1989, 2080, 2285, 2688, 3208, 3285, 3311, 3328], '(62)': [211], 'Google': [212, 231, 254, 267, 282, 347, 358, 382, 397, 475, 505, 543, 584, 633, 659, 691, 744, 774, 796, 824, 991, 1004, 1107, 1163, 1179, 1556, 1720, 1978, 1991, 2082, 2287, 2690, 3210, 3287, 3313, 3330], 'Scholar,': [213, 232, 255, 268, 348, 383, 634, 992, 1979, 3288, 3314], '2Bridger': [214], 'J.M.': [215, 234], 'Bickmore': [216, 239], 'W.A.': [217, 240], 'Trends': [218], 'Genet.': [219], '1998;': [220, 261, 499, 685], '14:': [221], '403-409Abstract': [222], 'Full': [223, 225, 246, 248, 625, 627, 651, 653, 788, 790], 'Text': [224, 226, 247, 249, 626, 628, 652, 654, 789, 791], 'PDF': [227, 250, 629, 655, 792], '(51)': [230], '3Bridger': [233], 'Boyle': [235], 'S.': [236, 1079, 1085, 2027, 2277], 'Kill': [237], 'I.R.': [238], 'Curr.': [241, 372, 2072], '2000;': [243], '10:': [244], '149-152Abstract': [245], '(220)': [253, 3329], '4Lamond': [256], 'A.I.': [257], 'Earnshaw': [258], 'W.C.': [259], 'Science.': [260], '280:': [262], '547-553Crossref': [263], '(771)': [266], '5Tumbar': [269], 'T.': [270, 618, 644, 813], 'Belmont': [271], 'A.S.': [272], 'Nat.': [273], 'Cell': [274, 352, 374, 576, 766, 1171, 1548, 2074, 2279], '3:': [277], '134-139Crossref': [278], '(156)': [281], 'Scholar).': [283, 544, 585, 745, 1005, 1108, 2288, 3211, 3331], 'This': [284, 2032, 2718, 3371, 4000], 'reflects': [287], 'multiplicity': [289], 'interactions': [291, 826, 842], 'between': [292, 1870, 3651], 'chromatin': [293, 360, 430, 449, 515, 2034, 2085, 2127, 2411, 2481, 2746, 3268, 3384], 'components': [294], 'integral': [296], 'or': [297, 408, 560, 1308, 1338, 1383, 1573, 1596, 1625, 1814, 1888, 1903, 2733, 2837, 2888, 3257, 3357, 3432, 3482, 3501, 3525, 3709], 'peripheral': [298, 334, 865, 906, 1941, 2005, 2309, 2349], 'proteins': [299, 1461, 1570, 1670, 2110, 2155, 2366, 2425, 2431, 2441, 2922, 3027], '(NE)': [304], '1The': [305], 'abbreviations': [306], 'used': [307, 1381, 1445, 2503, 3587], 'are:': [308], 'NE,': [309], 'envelope;': [311], 'HP1,': [312], '1;': [315], 'DTT,': [316, 1205, 1256, 1331, 1835], 'dithiothreitol;': [317], 'PMSF,': [318, 1334, 1743], 'phenylmethylsulfonyl': [319], 'fluoride;': [320], 'NG,': [321], 'ghost;': [323], 'GST,': [324, 3032], 'glutathione': [325], 'S-transferase;': [326], 'LBR,': [327, 2323], 'receptor;': [330], 'NEPH,': [331], 'fraction.': [336], '(6Georgatos': [337], 'S.D.': [338, 532, 616, 642, 735, 815, 982, 996, 1154, 1167, 1546, 1711, 2681], 'EMBO': [339, 467, 736, 816, 983, 997, 1155, 1712, 2682], '20:': [342], '2989-2994Crossref': [343], '(24)': [346], '7Foisner': [349], 'R.': [350, 497, 1071, 1087, 1093], 'Sci.': [353, 536, 3280], '114:': [355], '3791-3792Crossref': [356], 'Scholar).Because': [359], 'extensively': [362, 1951], 'differentially': [364], 'modified': [365, 927, 2890, 2896, 3421, 3445, 3555], '(8Fischle': [366, 2066], 'W.': [367, 385, 1091, 2067], 'Wang': [368, 386, 2068], 'Y.': [369, 387, 2069], 'Allis': [370, 388, 2070], 'C.D.': [371, 389, 572, 2071], 'Opin.': [373, 2073], '2003;': [376, 391, 469, 2076, 2281, 3281, 3324], '15:': [377, 739, 986, 1000, 1158, 1715, 2077, 2685], '172-183Crossref': [378, 2078], '(975)': [381, 2081], '9Fischle': [384], 'Nature.': [390, 498], '425:': [392], '475-479Crossref': [393], '(541)': [396], 'Scholar),': [398, 476, 775, 1992, 2083, 2691], 'it': [399, 422, 3560], 'tempting': [401], 'think': [403], 'certain': [405], 'marks': [407], 'factors': [409, 509], 'associated': [410, 2482, 2728, 3042], 'histone': [412, 1044, 1062, 2091, 2096, 2607, 2751, 2821, 3335, 3352, 3397, 3413, 3550], 'modifying': [413], 'enzymes': [414], 'provide': [415], 'sites': [417, 2039, 2340], 'for': [418, 1210, 1287, 1353, 1397, 1435, 1581, 1636, 1789, 2308, 3723], 'NE': [419, 462, 519, 697, 1269, 1306, 2109, 2154, 2304, 3940], 'proteins.': [420], 'However,': [421, 2117, 2211, 2859], 'equally': [424], 'possible': [425], 'transcriptionally': [427], 'active,': [428], 'noncondensed': [429], 'subjected': [432, 2769], 'silencing': [434], '"heterochromatinization"': [436], 'upon': [437, 2118], 'contact': [438], 'NE.': [441, 3963], 'Both': [442, 1020], 'hypotheses': [445], 'receive': [446], 'experimental': [447], 'support:': [448], 'silenced': [452], 'through': [453, 3641], 'SIRs': [456], 'can': [457, 719, 3561], 'tether': [458], 'itself': [459], '(10Spector': [463], 'D.L.': [464], 'Gasser': [465], 'S.M.': [466], 'Rep.': [468, 817], '4:': [470], '18-23Crossref': [471], '(13)': [474], 'whereas': [477, 776, 2330, 3424, 3904], 'targeting': [478], 'marker': [480], 'genes': [481], 'suppresses': [487], 'their': [488], 'expression': [489], '(11Andrulis': [490], 'E.D.': [491], 'Neiman': [492], 'A.M.': [493], 'Zappulla': [494], 'D.C.': [495], 'Sternglanz': [496], '394:': [500], '592-595Crossref': [501], '(389)': [504], 'Scholar).One': [506], 'been': [512, 833, 970, 1066, 3004], 'implicated': [513], 'anchorage': [516], 'receptor': [524], '(12Worman': [525], 'H.J.': [526, 570, 683, 781], 'Yuan': [527], 'Blobel': [529, 573, 1168], 'G.': [530, 574, 614, 640, 733, 980, 1081, 1152, 1169, 1709, 2679], 'Georgatos': [531, 615, 641, 734, 814, 981, 995, 1153, 1545, 1710, 2680], 'Proc.': [533], 'Natl.': [534], 'Acad.': [535], '1988;': [537], '85:': [538], '8531-8534Crossref': [539], '(296)': [542], 'polytopic': [548], 'consisting': [553], 'long,': [556], 'domain,': [558], 'seven': [559], 'eight': [561], 'hydrophobic': [562, 662], 'transmembrane': [563], 'regions,': [564], 'C-terminal': [567], 'tail': [568], '(13Worman': [569], 'Evans': [571], '1990;': [578], '111:': [579, 1102], '1535-1542Crossref': [580], '(192)': [583], 'part': [588, 4102], 'molecule': [591], 'protrudes': [592], 'nucleoplasm': [595], 'contains': [597, 3451], 'multiple': [598, 2038], 'serine-arginine': [599], 'motifs': [600], 'phosphorylated': [603], 'by': [604, 722, 1143, 1302, 1405, 1689, 1776, 1901, 2040, 2244, 2354, 2417, 2487, 2550, 2614, 2696, 2810, 2906, 2977, 3029, 3079, 3084, 3097, 3182, 3220, 3422, 3631, 3639, 3764, 3813, 3824, 3859, 3985, 3992, 4048, 4159], 'SRPK1': [606], 'cdc2': [609], 'kinases': [610], '(14Nikolakaki': [611], 'E.': [612, 636], 'Simos': [613, 639, 732, 979, 1151, 1708, 2678], 'Giannakouros': [617, 643, 812], 'Chem.': [621, 647, 784], '1996;': [622, 738, 768, 785, 985, 1157, 1714, 2684], '271:': [623, 786], '8365-8372Abstract': [624], '(88)': [632], '15Nikolakaki': [635], 'Meier': [637, 728, 975, 1147, 1704, 2674], '1997;': [648], '272:': [649], '6208-6213Abstract': [650], '(69)': [658, 1990], 'Scholar);': [660], 'region': [663, 3448], 'represents,': [664], 'instead,': [665], '(functional)': [667], 'form': [668, 3956], 'sterol': [670], 'reductase': [671], 'involved': [674], 'cholesterol': [676], 'metabolism': [677], '(16Holmer': [678], 'L.': [679, 1083, 2015, 2269, 2271, 3191, 3294, 3316], 'Pezhman': [680], 'A.': [681, 727, 807, 974, 1146, 1703, 2021, 2673, 3013, 3022], 'Worman': [682, 780], 'Genomics.': [684], '54:': [686], '469-476Crossref': [687], '(114)': [690], 'Scholar).Immunodepletion': [692], 'from': [695, 918, 1050, 1123, 1136, 1469, 1694, 1945, 2129, 2205, 2357, 2414, 2545, 2579, 2669, 2754, 2815, 2852, 2872, 2908, 3266, 4187], 'detergent-solubilized': [696], 'vesicles': [698, 1270, 1307], 'results': [699, 891], 'proteoliposomes': [701], 'diminished': [704], 'ability': [705], 'bind': [707], 'chromatin.': [708, 855], 'Furthermore,': [709, 3720], 'direct': [710, 777, 3645, 3721], 'electrophoretically': [713, 2499], 'purified': [714, 1273, 1468, 2500, 2637, 2695, 3797], 'metaphase': [717], 'chromosomes': [718], 'be': [720, 2064, 2782, 3360, 3476, 3494, 3562, 3629, 3762, 4041], 'demonstrated': [721], 'vitro': [724, 3725, 3949], 'assays': [725, 1448, 3507], '(17Pyrpasopoulou': [726, 973, 2672], 'Maison': [730, 977, 1149, 1706, 2676], '7108-7119Crossref': [740, 987, 1159, 1716, 2686], '(139)': [743, 990, 1162, 1719, 2689], 'Corroborating': [746], 'observations,': [748], 'anti-LBR': [749], 'antibodies': [750, 968, 1008, 1021, 1047, 1064, 1111, 1535, 2653, 2989, 3517, 3989, 4018, 4117], 'block': [751], 'assembly': [753], 'sea': [755], 'urchin': [756], 'egg': [757], 'extracts': [758, 1299, 1361, 1622, 2224, 2359, 3584], '(18Collas': [759], 'P.': [760, 1097, 2020, 2023], 'Courvalin': [761], 'J.C.': [762], 'Poccia': [763], '135:': [769], '1715-1725Crossref': [770], '(94)': [773], '(19Ye': [778], 'Q.': [779], '14653-14656Abstract': [787], '(326)': [795], 'Scholar)': [797, 825], 'indirect': [799, 3098, 3221, 3343], '(20Polioudaki': [800], 'H.': [801, 1095, 1544, 2013, 3189, 3272, 3292], 'Kourmouli': [802], 'N.': [803, 1077, 2011], 'Drosou': [804], 'V.': [805], 'Bakou': [806], 'Theodoropoulos': [808], 'P.A.': [809], 'Singh': [810, 1098], 'P.B.': [811, 1099], '2:': [819], '920-925Crossref': [820], '(145)': [823], '1': [830, 1203, 1206, 1254, 1257, 1329, 1332, 1637, 1755, 1816, 1830, 1833, 1837, 3024], '(HP1)': [831], 'claimed': [834], 'literature.Two': [837], 'critical': [838], 'parameters': [839], 'LBR-chromatin': [841], 'physical': [845], 'state': [846], 'molecular': [851, 2571, 3783, 3919, 3925], 'features': [852, 3261], 'To': [856, 2781, 3649, 3964], 'address': [857], 'issues,': [859], 'isolated': [862, 1688, 1944, 3387], 'fragments': [863], 'attached': [867], 'membrane.': [872], 'These': [873], 'subcellular': [874], 'fractions': [875, 1937, 3385], 'were': [876, 916, 923, 944, 1009, 1022, 1037, 1048, 1121, 1134, 1232, 1271, 1300, 1377, 1462, 1502, 1560, 1578, 1618, 1644, 1781, 1862, 1916, 1927, 1943, 1950, 1994, 2225, 2319, 2649, 2845, 2862, 3368, 3386, 3420, 3528, 3586, 3750, 3983, 4046], 'utilized': [877], 'affinity': [879, 2488], 'select': [880], 'associate': [883], 'investigate': [887], 'LBR-LBR': [888, 3646, 3822], 'interactions.': [889], 'obtained': [892, 917, 1122, 2204, 3728], 'reveal': [893, 2254], 'modification': [895, 2823, 3516], '"signatures"': [896], 'indicate': [901], 'interacts': [904], 'oligomer.EXPERIMENTAL': [911], 'PROCEDURESCells—Chicken': [912], 'turkey': [914, 1137], 'erythrocytes': [915, 3982, 4045], 'whole': [919, 1407, 1631, 2233], 'blood.': [920], 'HeLa': [921, 2317, 2645], 'cells': [922, 1466, 2318, 2648], 'grown': [924], "Dulbecco's": [926], "Eagle's": [928], 'medium': [929, 948], 'containing': [930, 949, 2855], '2': [931, 934, 950, 953, 1198, 1248, 1323, 1733, 2180, 2715, 2919], 'mm': [932, 935, 951, 954, 1196, 1199, 1204, 1207, 1238, 1241, 1246, 1249, 1252, 1255, 1258, 1313, 1316, 1321, 1324, 1327, 1330, 1333, 1423, 1729, 1734, 1742, 1745, 1751, 1756, 1760, 1823, 1831, 1834, 1838], 'l-glutamine,': [933, 952], 'penicillin/streptomycin,': [936, 955], '10%': [938, 956, 1201], 'fetal': [939, 957], 'calf': [940, 958], 'serum.': [941], 'Mouse': [942], 'fibroblasts': [943, 4186], 'maintained': [945], 'RPMI': [947], 'serum,': [959], '50': [961], 'μm': [962], '2-mercaptoethanol.Antibodies—The': [963], 'characterization': [964, 1058], 'anti-chicken': [966, 2987, 4072, 4115], 'has': [969, 1065], 'described': [971, 1067, 1415, 1699], 'previously': [972], '21Meier': [993], '1994;': [999], '1888-1898Crossref': [1001], '(73)': [1003], 'Anti-mammalian': [1006], 'produced': [1010], 'using': [1011, 1366, 1374, 1889, 2172, 2396, 2406, 2560, 2985, 3729], 'an': [1012, 2408, 2506, 4104], 'antigen': [1013], 'His-tagged': [1014], 'human': [1018, 1035], 'LBR.': [1019, 2175, 2858, 3733], 'affinity-purified': [1023, 2986, 3988, 4114], 'Affi-Gel': [1025, 1683, 1770, 2702, 2853], 'matrices': [1026], 'which': [1028, 3450], 'domains': [1031], 'chicken': [1033, 3986], 'coupled.': [1038], 'Anti-dimethylated': [1039], 'Lys4': [1040, 3333], 'acetylated': [1042, 3364, 3434, 3526], 'Lys14': [1043, 3527, 3568], 'H3': [1045, 1063, 2092, 2097, 2608, 3130, 3336, 3353, 3401, 3419, 3442, 3520, 3551], 'polyclonal': [1046], 'purchased': [1049], 'Upstate': [1051], 'Biotechnology,': [1052], 'Inc.': [1053], '(Lake': [1054], 'Placid,': [1055], 'NY).': [1056], 'anti-trimethylated': [1060], 'Lys9': [1061, 3452, 3524, 3557], '(22Cowell': [1068], 'I.G.': [1069], 'Aucott': [1070], 'Mahadevaiah': [1072], 'S.K.': [1073], 'Burgoyne': [1074], 'P.S.': [1075], 'Huskisson': [1076], 'Bongiorni': [1078], 'Prantera': [1080], 'Fanti': [1082, 2270], 'Pimpinelli': [1084, 2276], 'Wu': [1086], 'Gilbert': [1088], 'D.M.': [1089], 'Shi': [1090], 'Fundele': [1092], 'Morrison': [1094], 'Jeppesen': [1096], 'Chromosoma.': [1100, 3323], '2002;': [1101, 3204, 3307], '22-36Crossref': [1103], '(230)': [1106], 'Affinity-purified': [1109], 'secondary': [1110, 1534], 'Alexa': [1113], 'Fluor': [1114], 'goat': [1115], 'anti-rabbit': [1116], 'donkey': [1118], 'anti-rat': [1119], 'IgGs': [1120], 'Molecular': [1124, 1481], 'Probes': [1125], '(Eugene,': [1126], 'OR).Cell': [1127], 'Fractionation': [1128, 1602, 1660], 'Preparation': [1130, 1604, 1662], 'Nuclear': [1132, 1606, 1664, 4174], 'Extracts—NEs': [1133], 'prepared': [1135, 1301, 1404], 'erythrocyte': [1138, 4105], 'nuclei,': [1139], 'essentially': [1140, 1697, 2087], 'specified': [1142], 'Refs.': [1144], '17Pyrpasopoulou': [1145, 1702], 'Scholar': [1164, 1180], '23Georgatos': [1166], '1987;': [1173], '105:': [1174], '117-125Crossref': [1175], '(210)': [1178], 'slight': [1182], 'modifications.': [1183], 'Briefly,': [1184], 'after': [1185, 3704, 3887, 4109], 'three': [1186, 1610], 'rounds': [1187], 'DNase': [1189, 1410, 1627, 1954, 2041, 2229, 2245, 2418], 'I': [1190, 1236, 1411, 1628, 1955, 2042, 2230, 2246, 2419], 'digestion': [1191, 1225, 2247], '(80': [1192, 1412], 'μg/ml': [1193, 1218], '10': [1195], 'NaPO4,': [1197], 'MgCl2,': [1200, 1250, 1325], 'sucrose,': [1202, 1247, 1322], 'PMSF/protease': [1208], 'inhibitors': [1209], '15': [1211], 'min': [1212, 1355, 1437, 1583, 1791], 'at': [1213, 1266, 1290, 1294, 1356, 1394, 1431, 1438, 1584, 1639, 1765, 1792, 1849, 1877, 2037, 2056, 2138, 2926, 3034, 3045, 3435, 3472, 3491, 3523, 3556, 3659, 3685, 3958, 4027, 4087, 4123, 4215], 'room': [1214, 1585, 1640, 1766, 1793], 'temperature,': [1215], '200': [1217], 'RNase': [1219, 1957], 'A': [1220, 1400, 1483, 2385, 2395, 2405, 3973, 4014, 4021, 4066], 'included': [1221, 3005], 'last': [1224], 'step),': [1226], 'ghosts': [1230], '(NGs)': [1231], 'washed': [1233, 1645, 3665], 'buffer': [1235, 1367, 1375, 1594, 1649, 1655, 1799, 1813, 2554], '(150': [1237], 'NaCl,': [1239, 1314, 1818], '20': [1240, 1315], 'Tris-HCl,': [1242, 1317, 1824], 'pH': [1243, 1318, 1731, 1753, 1825], '7.5,': [1244, 1319, 1732, 1754], '250': [1245, 1320], '0.1': [1251, 1326], 'EGTA,': [1253, 1328, 1832], 'PMSF),': [1259], 'sonicated': [1260, 1309, 2399], 'induce': [1262], 'vesiculation,': [1263], 'stored': [1265], '-80': [1267], '°C.': [1268, 1440], 'further': [1272, 1384, 1634, 2119], 'flotation': [1275, 2123], 'gradients': [1276, 1390], '(70,': [1277], '50,': [1278], '30,': [1279], '20%': [1281], 'sucrose': [1282, 1388, 2122], 'cushions;': [1283], '100,000': [1284], '×': [1285, 1351, 1392, 1433], 'g': [1286, 1352, 1393, 1434], '18': [1288, 1398], 'h': [1289, 1638, 1764], '4': [1291, 1357, 1395, 1439], '°C),': [1292, 1358], 'collecting': [1293, 2137], '50–30%': [1296], 'interface.': [1297], 'thorough': [1303, 1796], 'resuspension': [1304], 'NGs': [1310, 1993, 2103, 2996], '300–600': [1312], 'protease': [1335], 'inhibitors,': [1336], 'plus': [1337], 'minus': [1339], '1%': [1340, 1426, 1827], 'Triton': [1341, 1372, 1427, 1513, 1739, 1828], 'X-100': [1342, 1428], '(buffers': [1343], 'S': [1344, 1595, 1800], 'ST,': [1346], 'respectively).': [1347], 'After': [1348, 1608, 1795], 'ultracentrifugation': [1349], '(200–350,000': [1350], '30': [1354, 1436, 1582, 1588], 'soluble': [1360, 1442], '(SE,': [1362, 1623], '"just': [1363], 'salt"': [1364], 'extract': [1365, 1373, 2516, 3105, 3228], 'S;': [1368], 'STE,': [1369, 1624], 'salt': [1370, 2209, 2358, 3595, 3662], 'ST)': [1376], 'collected': [1378], 'either': [1380, 1808, 1886, 2730, 2886, 3478, 3496, 3638], 'immediately,': [1382], 'fractionated': [1385], '5–20%': [1387], 'density': [1389], '(100,000': [1391], '°C': [1396], 'h).': [1399], 'euchromatin-enriched': [1401, 2228], 'fraction': [1402, 2145, 2165, 2412, 2528, 2534, 2706], 'was': [1403, 1419, 1444, 1536, 1687, 1725, 1772, 1806, 1847, 1876, 1884, 2035, 2086, 2327, 2341, 2518, 3337, 3372, 3404, 3426, 3443, 3698, 3727, 3787, 3978, 4025], 'digesting': [1406], 'nuclei': [1408, 1949, 2234, 2416], 'μg/ml,': [1413], 'above).': [1416], 'digest': [1418, 1629], 'adjusted': [1420], '300': [1422], 'NaCl': [1424, 3670], 'centrifuged': [1430], '15,000': [1432], 'phase': [1443], 'pull-down': [1447, 2170, 3015, 3590, 3657], '(see': [1449, 1598, 2053, 2737, 4034], 'below).Expression': [1450], 'Purification': [1452], 'Recombinant': [1454], 'Proteins—Glutathione': [1455], 'S-transferase': [1456], '(GST),': [1457], 'GST-fused,': [1458], 'His6-tagged': [1460, 3732], 'expressed': [1463], 'BL21(DE3)': [1465], 'lysates': [1470], 'according': [1471, 1538, 1929], 'standard': [1473], 'procedures': [1474], '(24Sambrook': [1475], 'Fritsch': [1477], 'E.F.': [1478], 'Maniatis': [1479], 'T.M.': [1480], 'Cloning:': [1482], 'Laboratory': [1484, 1491], 'Manual.': [1485], '3rd': [1486], 'Ed.': [1487], 'Cold': [1488, 1493], 'Spring': [1489, 1494], 'Harbor': [1490], 'Press,': [1492], 'Harbor,': [1495], 'NY1989Google': [1496], 'Scholar).Microscopy—For': [1497], 'light': [1498], 'microscopy,': [1499], 'samples': [1501, 2513, 2771, 2850, 3880], 'fixed': [1503], '1–4%': [1505], 'formaldehyde': [1506], 'phosphate-buffered': [1508], 'saline,': [1509], 'permeabilized': [1510, 2316, 2644], '0.2%': [1512], 'X-100,': [1514, 1740, 1829], 'blocked': [1516], '0.5%': [1518], 'fish': [1519], 'skin': [1520], 'gelatin.': [1521], 'DNA': [1522, 2052, 2577], 'staining': [1523, 2336, 4007], '(4′,6-diamidino-2′-phenylindole-dihydrochrolide,': [1524], 'propidium': [1525], 'iodide)': [1526], 'probing': [1528], 'relevant': [1531, 2992], 'primary': [1532], 'performed': [1537, 1848, 2169, 3655], 'Ref.': [1540, 1701], '25Maison': [1541], 'Horstmann': [1543], '1993;': [1550], '123:': [1551], '1491-1505Crossref': [1552], '(61)': [1555], 'Scholar.': [1557, 1721], 'specimens': [1559], 'visualized': [1561, 2655, 4077, 4108], 'Leica': [1564], 'SP': [1565], 'confocal': [1566, 2658, 3993, 4080], 'microscope.Pull-down': [1567], 'Assays—GST': [1568], 'fusion': [1569, 2187], '(LBR-GST,': [1571], 'M31-GST,': [1572], 'GST': [1574, 2186, 2372, 2444, 2587, 2638, 2940, 2982, 3817], 'alone;': [1575], '10–30': [1576], 'μg)': [1577], 'incubated': [1579, 1635, 2320], 'first': [1580], 'temperature': [1586], 'μl': [1589], 'glutathione-agarose': [1591], 'beads': [1592, 1617, 1643], 'ST': [1597, 1650], 'above': [1599], 'under': [1600, 2331, 3579], '"Cell': [1601, 1659], 'Extracts").': [1607], 'washing': [1609, 1797, 3705], 'times': [1611, 1647], 'same': [1614, 2333, 2392, 2402, 2820, 3774], 'medium,': [1615], 'combined': [1619], 'nuclei)': [1632], 'temperature.': [1641, 1794], 'five': [1646], 'once': [1652], 'isotonic': [1654], '(buffer': [1656], 'I,': [1657, 2807], 'see': [1658, 2800], 'Extracts")': [1665], 'before': [1666], 'eluting': [1667], 'bound': [1669, 1804, 2527], 'hot': [1672, 1810, 2551], 'SDS': [1673, 1811, 2552, 2755, 3868], 'sample': [1674, 1812, 2553], 'buffer.Purification': [1675], 'Native': [1677], 'Affinity': [1680], 'Chromatography': [1681], 'Matrices—Full-length,': [1684], 'NE-associated': [1685, 2084, 3258], 'preparative': [1690, 2697], 'SDS-PAGE': [1691], 'elution': [1693, 2549], 'gel': [1695, 2388, 2491, 3826], 'pieces,': [1696], 'eluted': [1723, 1807, 2851], 'reconstituted': [1726], '100': [1728, 1750], 'Hepes-NaOH,': [1730, 1752], 'EDTA,': [1735, 1757], '0.1%': [1736], 'SDS,': [1737], '2%': [1738], '0.2': [1741, 1759], '0.05': [1744], 'DTT': [1746], 'dialyzed': [1748], 'against': [1749], 'PMSF': [1761], '(for': [1762, 2798, 2877], '5': [1763, 1819], 'temperature).': [1767], 'Coupling': [1768], '10/15': [1771], 'done': [1773, 1885], 'recommended': [1775], 'manufacturer': [1778], '(Bio-Rad).': [1779], 'SEs': [1780, 2397, 2711], 'applied': [1782, 2519], 'Affi-Gel-LBR': [1785], 'column': [1786, 1802, 1925, 2522, 2547], 'batch-incubated': [1788], '90': [1790], '(15': [1801], 'volumes),': [1803], 'material': [1805, 2136, 2352, 2629, 2904, 2975, 3040, 3811], 'm': [1817, 1820, 3036, 3050, 3661, 3687, 3711], 'urea,': [1821], '40': [1822], '8.0,': [1826], 'PMSF.Other': [1839], 'Methods—Matrix-assisted': [1840], 'laser': [1841, 2776], 'desorption': [1842, 2777], 'ionization': [1843, 2778], 'time-of-flight': [1844, 2779], 'mass': [1845, 2773, 2874, 3080, 3457, 3784], 'spectrometry': [1846, 2774], 'Functional': [1851], 'Genomics': [1852], 'Unit': [1853], 'Moredun': [1855], 'Research': [1856], 'Institute': [1857], '(Edinburgh,': [1858], 'UK).': [1859], 'Protein': [1860], 'bands': [1861, 2753, 3847], 'digested': [1863, 1952], 'R-specific': [1865], 'protease.': [1866], 'ΔM': [1867], '(the': [1868], 'difference': [1869, 3458], 'measured': [1872], 'calculated': [1874], 'masses)': [1875], 'level': [1879, 3960], '1/10,000.': [1881], 'Peak': [1882], 'assignment': [1883], 'manually': [1887], 'appropriate': [1890], 'Expasy': [1891], 'programs.': [1892], 'Ambiguous': [1893], 'peaks': [1894, 2828, 2883], '(e.g.': [1895, 2111], 'those': [1896, 2759], 'precipitated': [1900, 2196, 2353, 2905, 2976, 3028, 3603, 3812], 'recombinant': [1902, 1912, 2213, 2216, 2322, 2355, 2434, 2457, 2735, 2794, 2836, 2843, 3113, 3119, 3236, 3242, 3509, 3600, 3681, 3743], 'endogenous': [1904, 1914, 2796, 2841, 2857, 3622], 'but': [1906, 2093], 'not': [1907, 1917, 2219, 2846, 2866, 2893, 3090, 3093, 3213, 3216, 3338, 3369, 3380, 3544, 3570, 3788], 'protein)': [1915], 'taken': [1918], 'into': [1919], 'account.': [1920], 'SDS-PAGE,': [1921], 'Western': [1922, 2615, 2971, 3512, 3632], 'blotting,': [1923], 'chromatography': [1926], 'practiced': [1928], 'established': [1931], 'procedures.RESULTSLBR': [1932], 'Associates': [1933], 'Peripheral': [1935], 'Heterochromatin—Subnuclear': [1936], 'highly': [1938], 'enriched': [1939], 'avian': [1946, 3981, 4060], 'erythrocytes.': [1947, 4061], 'Intact': [1948], 'A,': [1958, 2351, 2764, 2903, 3794], 'yielding': [1959, 3766], 'NGs.': [1960, 2400], 'Consistent': [1961, 2311], 'previous': [1963, 2670], 'observations': [1964, 2252], '(26Harris': [1965], 'J.R.': [1966, 1981], 'Brown': [1967], 'J.N.': [1968], 'Ultrastruct.': [1970], 'Res.': [1971], '1971;': [1972], '36:': [1973], '8-23Crossref': [1974], '(37)': [1977], '27Harris': [1980], 'Biochim.': [1982], 'Biophys.': [1983], 'Acta.': [1984], '1978;': [1985], '515:': [1986], '55-104Crossref': [1987], 'content': [1998], 'retained': [2000, 3699], 'only': [2001, 3849], 'layer': [2003], '(Fig.': [2007, 2098, 2156, 2235, 2344, 2712, 3539, 3617, 3634, 3757, 3790, 3995, 4019, 4052], '1A).': [2008], '2D.': [2009], 'Makatsori,': [2010], 'Kourmouli,': [2012], 'Polioudaki,': [2014], 'Shultz,': [2017], 'K.': [2018, 3187, 3270, 3290], 'Mclean,': [2019], 'Theodoropoulos,': [2022], 'B.': [2024, 2275, 3275], 'Singh,': [2025], 'Georgatos,': [2029], 'unpublished': [2030], 'data.': [2031], '"residual"': [2033], 'cut': [2036], 'represented': [2044], 'mononucleosomal': [2045], 'variable': [2048], 'portions': [2049], 'linker': [2051], 'broad': [2054], 'band': [2055], '150–200': [2057], 'bp': [2058], 'Fig.': [2060, 2115, 2179, 2762, 2801, 3348, 3689, 3694, 3737], '1B).': [2061], 'As': [2062, 2176, 2803, 3691, 3734], 'could': [2063, 3359, 3475, 3493, 3628, 3761, 4039], 'expected': [2065, 2668], 'depleted': [2088], 'Lys4-dimethylated': [2090], 'possessed': [2094, 2147], 'Lys9-trimethylated': [2095, 2606], '1D).On': [2099], 'mg/mg': [2101], 'basis,': [2102], 'contained': [2104, 2709], 'more': [2106, 2783, 4178], 'than': [2108], 'lamins': [2112], 'LBR;': [2114, 3059, 3114, 3117, 3120, 3237, 3240, 3243], '1C).': [2116], 'fractionation': [2120], 'gradients,': [2124], 'loosely': [2125], 'attaching': [2126], 'dissociated': [2128], '30–50%': [2140], 'interface': [2141], '(nuclear': [2142], 'envelope-peripheral': [2143], '(NEPH))': [2146], 'almost': [2148, 2818], 'stoichiometric': [2149, 2198], 'amounts': [2150, 2199], '1C).To': [2157], 'examine': [2158], 'whether': [2159], 'associates': [2161], 'chromatin,': [2167, 2611], 'experiments': [2171, 3591], 'exogenous': [2173], '(recombinant)': [2174], 'shown': [2177, 2760, 2804, 3020, 3735, 3912], '(A,': [2181], 'B,': [2182, 2391, 2765, 2970, 3819], 'E),': [2184], 'corresponding': [2189, 3459, 3906], 'roughly': [2197], 'heterochromatin-derived': [2201], 'core': [2202], 'NG': [2206], 'NEPH': [2208, 2223], 'extracts.': [2210, 2902, 2910], 'unlike': [2212], 'HP1': [2214, 2240, 2435], '(M31),': [2215], 'did': [2218, 2865, 3379], 'precipitate': [2220, 2582, 3627, 3703], 'nucleosomes': [2221, 2299, 2708, 2808, 2813, 3548, 3679, 3717], 'when': [2222, 2315, 2559, 3382, 3713, 3980, 4043], 'substituted': [2226], 'digests': [2231], '2C).': [2236], 'released': [2243, 2413], 'consistent': [2249, 3340], 'recent': [2251], 'role': [2256], 'this': [2258, 2313, 2561, 3542, 3966], 'both': [2264, 3366, 4028], 'hetero-': [2265], 'euchromatin': [2267], '(28Piacentini': [2268], 'Berloco': [2272], 'Perrini': [2274], '161:': [2282], '707-714Crossref': [2283], '(178)': [2286], 'On': [2289], 'other': [2291, 3061], 'hand,': [2292], 'selective': [2294], 'co-fractionate': [2301], 'indicates': [2305], 'preference': [2307], 'heterochromatin.': [2310, 2350], 'idea,': [2314, 3967], 'intensely': [2328], 'decorated,': [2329], 'conditions,': [2334, 3775], 'internal': [2338], 'rather': [2342], 'faint': [2343], '2G).Fig.': [2345], '2LBR': [2346], 'LBR-GST': [2356, 2581, 2641, 2907, 2925, 2952, 2966, 2978, 3000, 3030, 3044, 3626, 3702, 3798, 3838, 3854], '(SE)': [2360], 'floated': [2362], 'NEPHs.': [2363], 'Lane': [2364, 2423, 2911, 3801, 3828], '1,': [2365, 2424, 2912, 3802, 3829], 'co-sedimenting': [2367, 2426, 2432, 2442, 2923, 3057], 'LBR-GST;': [2369, 2377, 2428, 3804, 3814, 3831], 'lane': [2370, 2374, 2378, 2429, 2439, 2447, 2524, 2942, 3805, 3809, 3815, 3832, 3836, 3841], '2,': [2371, 2430, 2763, 3806, 3833], 'control;': [2373], '3,': [2375, 2440, 3810, 3837], 'input': [2376, 2383, 2409, 2452, 2916, 2947, 3803, 3807, 3830, 3834], '4,': [2379, 2448, 2921, 3816, 3842], 'portion': [2380, 2449, 2913, 2944], '(10%)': [2381, 2450], 'extract.': [2384], 'Coomassie': [2386, 3872], 'Blue-stained': [2387], 'shown.': [2390, 2631], 'C,': [2401, 3014, 3861], 'intact': [2415], 'treatment': [2420], '(euchromatic': [2421], 'fraction).': [2422], '(M31-GST;': [2436], 'positive': [2437], 'control);': [2438, 2446], '(negative': [2445], 'digest.': [2453, 2477], 'positions': [2455, 2592], '(rLBR)': [2459, 2953], 'its': [2461], 'characteristic': [2462, 2962], 'degradation': [2463, 2963], 'products': [2464, 2964, 3886], '(d.p.)': [2465], 'indicated.': [2467, 2600, 2960], 'Hb': [2468], 'denotes': [2469], 'residual': [2470], 'hemoglobin': [2471], 'chains': [2472], 'present': [2473, 3529], 'crude': [2476], 'D,': [2478], 'isolation': [2479], 'endogenous,': [2484, 3608], 'full-length': [2485, 3609], 'chromatography.': [2489], 'on': [2492, 3901, 3913], 'left': [2494], 'shows': [2495, 4083], 'profile': [2497, 2575], '(nLBR)': [2502, 2958], 'construct': [2505], 'LBR-Affi-Gel': [2507], 'matrix;': [2508], 'right': [2510, 4150], 'panel': [2511], 'depicts': [2512], '(SE;': [2523], '1),': [2525], '(lane': [2529, 2535, 2583, 2589, 2979, 2983, 2997, 3001], '2)': [2530, 2628, 2984], 'nonbound': [2533, 2621], '3).': [2536, 2717], 'An': [2537, 3895], 'asterisk': [2538], 'points': [2539], 'traces': [2541, 3053, 3612], 'nLBR': [2543], '"leaking"': [2544], 'during': [2548], '(this': [2555], 'commonly': [2557], 'seen': [2558], 'matrix).': [2562], 'Lanes': [2563, 3023], 'M': [2564], 'correspond': [2565], 'markers': [2567, 2598, 3921], 'indicated': [2570, 3858, 3924, 4158], 'masses.': [2572], 'E,': [2573, 4101], 'electrophoretic': [2574], 'extracted': [2578, 2814], '1)': [2584, 2623, 2980], 'control': [2588, 3777, 3907], '2).': [2590], '1000-': [2595], '300-bp': [2597], 'F,': [2601, 3095, 3218], 'detection': [2602, 3820], 'Lys14-acetylated': [2604], 'LBR-precipitated': [2610], 'documented': [2613], 'blotting.': [2616], 'Equal': [2617], 'proportions': [2618], '(lanes': [2622, 2627], 'LBR-bound': [2626], 'G,': [2632], 'situ': [2634, 4055], '(+GST)': [2639], '(+LBR-GST)': [2642], 'cells.': [2646], 'stained': [2650, 3870], 'anti-GST': [2652], 'microscope.View': [2659], 'Large': [2660, 3067, 3929, 4161], 'Image': [2661, 3068, 3930, 4162], 'Figure': [2662, 3069, 3931, 4163], 'ViewerDownload': [2663, 3070, 3932, 4164], 'Hi-res': [2664, 3071, 3933, 4165], 'image': [2665, 3072, 3934, 4166], 'Download': [2666, 3073, 3935, 4167], '(PPT)As': [2667], 'studies': [2671], 'native': [2692, 2732, 2955, 3111, 3116, 3234, 3239, 3676, 3696, 3825, 3953], '(endogenous)': [2693, 2956], 'electrophoresis': [2698], 'coupled': [2700], 'also': [2703, 2786, 4040], '"selected"': [2704], '2D,': [2713], 'lanes': [2714, 2918, 2936, 3038], 'enabled': [2719], 'comparisons': [2720], 'chemical': [2723], 'modifications': [2724, 3076], 'H3/H4': [2727, 2752, 2822], 'below).Modification': [2738], 'Signatures': [2739], 'NE/LBR-associated': [2741], 'Chromatin—To': [2742], 'characterize': [2743], 'fraction,': [2747], 'excised': [2749], 'gels': [2756, 3756, 3869], '(similar': [2757], 'D)': [2767], '(matrix-assisted': [2775], 'MS).': [2780], 'systematic,': [2784], 'analyzed': [2787], 'co-precipitating': [2789], 'details': [2799], '3A).': [2802, 3618, 3690], 'Table': [2806], 'affinity-selected': [2809], 'NEs': [2816], 'yielded': [2817], 'signatures.': [2824], 'Some': [2825, 4195], 'co-precipitated': [2834], 'columns': [2854], 'exclusively': [2856], 'differences': [2861], 'minor': [2863], 'alter': [2867], 'overall': [2869], 'picture': [2870], 'emerging': [2871], 'data': [2876, 3345], 'instance,': [2878], 'most': [2879], 'missing': [2882], 'corresponded': [2884], 'nonmodified': [2887, 3406], 'partially': [2889, 3431], 'peptides': [2891], 'fully': [2895, 3433], 'ones).Fig.': [2897], '3LBR': [2898], 'self-association': [2899], 'STE': [2901, 2909], '(20%)': [2914], 'extract;': [2917], 'intermediate': [2927], '(0.3': [2928], 'm)': [2929, 2933], 'high': [2931], '(0.6': [2932], 'salt,': [2934, 3712], 'respectively;': [2935], '3': [2937], '5,': [2939, 3026, 3996, 4020], 'controls;': [2941], '6,': [2943], '(40%)': [2945], 'LBR-GST.': [2948], 'position': [2950], 'labeled': [2968], 'd.p.': [2969], 'blot': [2972], '(only': [2990], 'area': [2993], 'shown).': [2995], '3)': [2998], '4)': [3002], 'standards.': [3007], 'designations': [3009, 3062], 'assay': [3016, 3658, 3896], 'similar': [3017], 'respectively,': [3033], '0.3': [3035, 3660], 'salt;': [3037], '2–4,': [3039], 'remaining': [3041], '0.4,': [3046, 3707], '0.45,': [3047, 3708], '0.5': [3049, 3710], 'NaCl.': [3051], '(LmB),': [3052], 'A.View': [3066], '(PPT)Table': [3074], 'IHistone': [3075], 'spectrometryPeaka/aModificationsBulkaBulk,': [3081], 'reported': [3083, 3181], 'Zhang': [3085, 3183], 'et': [3086, 3184], 'al.': [3087, 3185], '(30).': [3088], 'NR,': [3089, 3212], 'reported;': [3091, 3214], 'ND,': [3092, 3215], 'detected;': [3094, 3217], 'immunofluorescence;': [3099, 3222], 'a/a,': [3100, 3223], 'amino': [3101, 3224, 4207], 'acid': [3102, 3225], 'position;': [3103, 3226], 'Extra,': [3104, 3227], 'NE:': [3107, 3230], 'N': [3108, 3231], '+': [3109, 3127, 3139, 3141, 3144, 3146, 3155, 3232], 'R,': [3110, 3118, 3233, 3241], 'N,': [3115, 3238], 'nm,': [3121, 3244], 'nonmodified;': [3122, 3245], 'ac,': [3123, 3246], 'acetylated;': [3124, 3247], 'me,': [3125, 3248], 'methylatedExtrN': [3126], 'RNRModified': [3128], 'residueHistone': [3129], '704.43-8nm+++ND+Lys4': [3131], '718.4me+----': [3132], '732.42×me+F----': [3133], '746.43×meNR----': [3134], '901.59-17nm+++++Lys9,Lys14': [3135], '943.53×me': [3136], '(ac)+++++': [3137], 'n.53×me': [3138], '2×me+++++(ac': [3140], '2×me)': [3142], '985.53×me': [3143], '3×me+++++(ac': [3145], '3×me)': [3147], '986.618-26nmNR----Lys18,': [3148], 'Lys23': [3149, 3358], '1028.6ac+++++': [3150], '1070.62×ac+----': [3151], '1433.827-40nm+----Lys27,': [3152], 'Lys36': [3153, 3417], '.83×me': [3154], 'me+++++': [3156], '1250.754-63nm+++++Lys51': [3157], '788.864-69nm+++++Lys64': [3158], '1335.673-83nm+++++Lys79': [3159], 'n.62×me+++ND+': [3160], '1384.8117-128nm+++++Lys122Histone': [3161], 'H4': [3162, 3403, 3425], '1270.84-17nm+++ND+Lys5,': [3163], 'Lys8,': [3164, 3437], 'Lys12,': [3165, 3438], 'Lys16': [3166], '81×ac+----': [3167], 'r.82×ac+++++': [3168], '.83×ac+++ND+': [3169], '515.320-23nm++---Lys20': [3170], 't.31×me+----': [3171], '543.3/855.52×me+++++': [3172], 'h.33×me+----': [3173], '1325.724-35nm+++++Lys31': [3174], '1386.856-67nm+++++Lys59': [3175], '1290.668-78nm+++++Lys77': [3176], '1594.979-92nm+++++Lys79,': [3177], 'Lys91a': [3178], 'Bulk,': [3179], '(30Zhang': [3186], 'Tang': [3188, 3271, 3291], 'Huang': [3190, 3293], 'Blankenship': [3192, 3295], 'J.W.': [3193, 3296], 'Jones': [3194, 3297], 'P.R.': [3195, 3298], 'Xiang': [3196, 3299], 'F.': [3197, 3300], 'Yau': [3198, 3301], 'P.M.': [3199, 3302], 'Burlingame': [3200, 3303], 'A.L.': [3201, 3304], 'Anal.': [3202, 3305], 'Biochem.': [3203, 3306], '306:': [3205, 3308], '259-269Crossref': [3206, 3309], '(126)': [3209, 3312], 'methylated': [3249], 'Open': [3250], 'table': [3251], 'new': [3254], 'tab': [3255], 'exhibited': [3260], 'clearly': [3263], 'differentiated': [3264], 'them': [3265], 'bulk': [3267], '(29Zhang': [3269], 'Chromatogr.': [3274], 'Analyt.': [3276], 'Technol.': [3277], 'Biomed.': [3278], 'Life': [3279], '783:': [3282], '173-179Crossref': [3283], '(34)': [3286], '30Zhang': [3289], '31Zhang': [3315], 'Eugeni': [3317], 'E.E.': [3318], 'Parthun': [3319], 'M.R.': [3320], 'Freitas': [3321], 'M.A.': [3322], '112:': [3325], '77-86Crossref': [3326], 'First,': [3332], 'modified,': [3339], 'immunofluorescence': [3344], 'presented': [3346], '1D;': [3349], 'second,': [3350], 'although': [3351], 'monoacetylated': [3354], 'Lys18': [3356], 'readily': [3361, 3751], 'identified,': [3362], 'species': [3363], 'residues': [3367], 'detected.': [3370], 'observed': [3373, 3979], 'several': [3375], 'different': [3376, 3537], 'preparations': [3377], 'change': [3381], 'presence': [3390, 3620], 'sodium': [3392], 'butyrate.In': [3393], 'nucleosomes,': [3395], 'fold': [3398], 'largely': [3405], '(with': [3407], 'exception': [3409], 'Lys79': [3411], 'H3).': [3414], 'Lys27': [3415], 'trimethylation,': [3423], 'dimethylated': [3427], 'Lys20': [3429], 'Lys5,': [3436], 'Lys16.': [3440], 'Histone': [3441], 'heavily': [3444], '9–17,': [3449], 'Lys14.': [3454], 'Because': [3455], 'lysine': [3461, 3468], 'trimethylation': [3462], 'equal': [3464], 'acetylation,': [3469], 'peak': [3471, 3490], '971.5': [3473], 'daltons': [3474], 'assigned': [3477], 'dimethylated/acetylated': [3481], 'dimethylated/trimethylated': [3485], '9–17': [3486], 'peptide.': [3487, 3505], 'Likewise,': [3488], 'another': [3489], '985.5': [3492], 'attributed': [3495], 'twice': [3499], 'trimethylated': [3500, 3522], 'trimethylated/acetylated': [3504], 'Pull-down': [3506], 'blotting': [3513, 3633], 'anti-histone': [3515], 'showed': [3518], 'subspecies': [3521], 'precipitate,': [3533], 'albeit': [3534], 'extent': [3538], '2F).': [3540], 'Although': [3541], 'does': [3543], 'prove': [3545], 'simultaneously': [3554], 'Lys14,': [3559], 'safely': [3563], 'concluded': [3564], 'acetylation': [3566], 'incompatible': [3571], 'binding.LBR': [3577], 'Self-associates': [3578], 'Vitro': [3581], 'Conditions—When': [3582], 'salt/detergent': [3583], '(STE)': [3585], 'instead': [3592], 'just': [3594], 'SEs,': [3596], 'noticed': [3598], 'consistently': [3602], 'co-migrating': [3606], 'confirmed': [3630], '3B)': [3635], 'explained': [3637], '"cross-linking"': [3640], 'nucleosomes/lamin': [3642], 'and/or': [3644], '(oligomerization).': [3648], 'distinguish': [3650], 'possibilities,': [3653], 'subsequently': [3664], 'precipitates': [3667], 'increasing': [3669], 'concentrations': [3671], '(notice': [3672], 'co-precipitation': [3674, 3795], 'abolished': [3684], '0.6': [3686], 'NaCl;': [3688], 'illustrated': [3692], '3C,': [3695], 'all': [3714], 'had': [3718], 'detached.': [3719], 'evidence': [3722], 'oligomerization': [3726], 'GST-tagged': [3730], '4A,': [3738], 'two': [3740, 3865], 'co-precipitated.': [3745], 'In': [3746], 'addition,': [3747], 'LBR-GST/LBR-His6': [3748], 'complexes': [3749, 3823], 'detectable': [3752], 'nondenaturing': [3754], 'acrylamide': [3755], '4B).': [3758], 'Finally,': [3759], 'LBR-His6': [3760, 3843, 3856, 3898], 'cross-linked': [3763, 3789], 'glutaraldehyde,': [3765], 'dimers': [3767], 'order': [3770], 'oligomers.': [3771], 'Under': [3772], 'analogous': [3780], 'charge': [3781], '(cytochrome': [3785], 'c)': [3786], '4C).Fig.': [3791], '4LBR': [3792], 'oligomerization.': [3793], 'LBR-His6.': [3800], 'LBR-His6;': [3808, 3835, 3840], 'control.': [3818], 'electrophoresis.': [3827], 'GST.': [3845], 'appearing': [3848], 'mixture': [3852], 'arrows.': [3860], 'cross-linking': [3862, 3885], 'experiments.': [3863, 3972], 'panels': [3866], 'show': [3867, 4126], 'Blue.': [3873], 'No': [3874], 'CL,': [3875], 'non-cross-linked': [3878], 'material;': [3879], '(3′)': [3881], '(10′)': [3883], 'depict': [3884], '3-': [3888], '10-min': [3890], 'incubations': [3891], '0.03%': [3893], 'glutaraldehyde.': [3894], 'depicted': [3900], 'left,': [3903], 'cytochrome': [3909], 'c': [3910], 'right.': [3915], 'migration': [3917], 'weight': [3920], 'masses': [3926], 'denoted.View': [3928], '(PPT)LBR': [3936], 'Resides': [3937], 'Distinct': [3939], 'Microdomains—That': [3941], 'oligomerized': [3947], 'suggested': [3950], 'might': [3955], 'explore': [3965], 'proceeded': [3969], 'morphological': [3971], 'striking,': [3974], '"lumpy"': [3975], 'fluorescence': [3976], 'pattern': [3977, 4002], 'decorated': [3984, 4063], 'LBR-specific,': [3987], 'examined': [3991, 4047, 4185], 'microscopy': [3994, 4051, 4112, 4142], 'C': [3997], 'D).': [3999], 'discontinuous': [4001], 'contrasted': [4003], 'smooth,': [4005], 'uniform': [4006], 'anti-lamin': [4013, 4016, 4065, 4068], 'B)': [4023], 'apparent': [4026], 'xy': [4029], 'xz': [4031], 'optical': [4032, 4099], 'sections': [4033], 'below).': [4035], 'Discrete': [4036], '"islets"': [4038], 'discerned': [4042], 'Triton-permeabilized': [4044], 'pre-embedding': [4049, 4110], 'immunoelectron': [4050, 4111], '5E).Fig.': [4053], '5In': [4054], 'Specimens': [4062], '(A),': [4067], '(B),': [4070], '(C)': [4074], 'antibodies,': [4075], 'microscope.': [4081], 'D': [4082], 'representative': [4084], 'profiles': [4086], 'contrast': [4089], 'magnification.': [4091], 'All': [4092], 'images': [4095, 4143], 'represent': [4096], 'nearly': [4097], 'equatorial': [4098], 'sections.': [4100], 'nucleus,': [4106], 'A-gold.': [4120], 'insets': [4122], 'bottom': [4125], 'low': [4128], 'power': [4129], 'view': [4130], 'entire': [4133], '(left': [4135], 'inset)': [4136], 'series': [4139], 'electron': [4141], 'clusters': [4145], 'immunogold': [4147], '(three': [4149], 'insets).': [4151], 'Cy,': [4152], 'cytoplasm;': [4153], 'Nu,': [4154], 'nucleus.': [4155], 'Magnification': [4156], 'bars.View': [4160], '(PPT)Heterozygous': [4168], 'Mutations': [4169], 'Affect': [4170], 'Organization': [4172], 'Structure—To': [4175], 'study': [4176], 'detail': [4179], 'vivo,': [4183], 'wild': [4188], 'type': [4189], 'ichthyosis': [4191], '(ic)': [4192], 'mouse': [4193], 'mutants.': [4194], 'mutations': [4198], '(icJ)': [4199], 'result': [4200], 'frame': [4203], 'shift': [4204], 'changes': [4206], 'acids': [4208], '365–385': [4209], 'introduces': [4211], 'stop': [4213], 'codon': [4214], 'residue': [4216], '386': [4217], 'gene.': [4221], 'Ho': [4222]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2057901296', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 11}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 9}], 'updated_date': '2024-12-07T15:56:18.227158', 'created_date': '2016-06-24'}
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