Angiotensin II Enhances Adenylyl Cyclase Signaling via Ca2+/Calmodulin

Name: Work Video:
Duration: 3 min 30 s
Rennolds S. Ostrom; Jennifer E. Naugle; Miki Hase; Caroline Gregorian; James S. Swaney; Paul A. Insel; Laurence L. Brunton; J. Gary Meszaros
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3987, 4009, 4119, 4128, 4133, 4145, 4149, 4242, 4247, 4251, 4303, 4310, 4339, 4353, 4384], 'the': [8, 169, 172, 178, 195, 207, 257, 418, 421, 427, 444, 456, 592, 637, 722, 732, 912, 920, 1020, 1207, 1215, 1303, 1318, 1324, 1331, 1368, 1415, 1492, 1494, 1510, 1637, 1723, 1754, 1769, 1781, 1784, 1841, 1929, 2257, 2267, 2322, 2412, 2483, 2492, 2530, 2541, 2588, 2732, 2795, 2799, 2884, 2914, 2956, 2993, 3035, 3062, 3078, 3099, 3115, 3164, 3183, 3201, 3229, 3238, 3461, 3565, 3583, 3620, 3650, 3655, 3705, 3723, 3747, 3816, 3867, 3875, 3919, 3928, 3988, 4007, 4018, 4026, 4069, 4109, 4122, 4141, 4183, 4223, 4377], 'heart,': [9, 258], 'playing': [10, 259], 'key': [11, 260, 1255], 'roles': [12, 261], 'cardiac': [14, 40, 247, 263, 289, 496, 504, 581, 640, 704, 744, 777, 814, 903, 924, 1025, 1261, 1295, 1339, 1376, 1594, 1945, 2299, 2620, 2881, 2911, 3009, 3135, 3281, 3315, 3490, 3544, 4129, 4166, 4243, 4291, 4370], 'remodeling': [15, 264, 517], 'and': [16, 28, 32, 49, 79, 86, 92, 95, 143, 150, 233, 242, 265, 277, 281, 298, 328, 335, 341, 344, 392, 399, 482, 491, 512, 528, 583, 642, 731, 811, 817, 824, 916, 984, 987, 1011, 1016, 1062, 1075, 1121, 1173, 1179, 1181, 1220, 1272, 1327, 1381, 1407, 1411, 1429, 1451, 1460, 1466, 1471, 1500, 1514, 1527, 1555, 1566, 1603, 1610, 1702, 1757, 1776, 1813, 1873, 2003, 2034, 2109, 2116, 2130, 2172, 2196, 2263, 2266, 2321, 2331, 2390, 2399, 2454, 2557, 2575, 2600, 2606, 2686, 2697, 2710, 2731, 2756, 2774, 2794, 2813, 2818, 2833, 2842, 2876, 2895, 3032, 3043, 3086, 3155, 3161, 3210, 3252, 3257, 3289, 3297, 3447, 3465, 3485, 3540, 3625, 3710, 3732, 3739, 3826, 3830, 3877, 3893, 3914, 4067, 4089, 4148, 4177, 4215, 4297, 4315, 4324, 4334, 4348], 'hypertrophy.': [17, 266], 'In': [18, 267, 1937, 2585, 2883], 'this': [19, 122, 268, 371, 929, 3065, 3882, 3958], 'study,': [20, 269], 'we': [21, 270, 1365, 1394, 2889, 3123, 3232, 3563, 3765, 3916, 4137, 4289], 'sought': [22, 271, 3899, 4138], 'to': [23, 192, 272, 441, 586, 833, 870, 926, 1322, 1426, 1440, 1541, 1580, 1630, 1720, 1768, 1787, 1885, 1888, 2029, 2060, 2281, 2291, 2302, 2317, 2340, 2410, 2549, 2625, 2652, 2735, 2753, 2760, 2920, 2946, 3037, 3048, 3130, 3236, 3248, 3283, 3587, 3610, 3648, 3719, 3728, 3763, 3795, 3852, 3859, 3874, 3900, 4005, 4057, 4139, 4151, 4233, 4293, 4380], 'characterize': [24, 273], 'cross-talk': [25, 179, 239, 274, 428, 488, 1332, 2892, 2948, 3398, 3578, 3717, 3904, 3920], 'between': [26, 240, 275, 489, 1217, 1253, 1333, 2830, 2893, 4332], 'Gq': [27, 241, 276, 490, 632, 1633, 1692, 2894, 2907, 3102, 3112, 3129, 3142, 3209, 3227, 3464, 3531], 'Gs': [29, 243, 278, 492, 698, 1271, 2896], 'signaling': [30, 244, 279, 493, 1251, 1336, 1398, 1572, 3219, 3256, 4135], 'pathways': [31, 245, 280, 494, 1259, 1337, 3488], 'its': [33, 282, 917, 3132, 3356], 'impact': [34, 283], 'on': [35, 284, 1802, 2160, 2305, 2349, 2383, 2772, 3120, 3753, 3896, 3974, 4075], 'modulating': [36, 285], 'collagen': [37, 50, 187, 203, 231, 286, 299, 436, 452, 480, 701, 741, 818, 900, 1386, 1409], 'synthesis': [38, 51, 188, 204, 232, 287, 300, 437, 453, 481, 527, 742, 819, 901, 913, 1387], 'by': [39, 60, 70, 75, 81, 288, 309, 319, 324, 330, 580, 703, 743, 776, 807, 1008, 1068, 1125, 1133, 1177, 1186, 1188, 1287, 1352, 1400, 1564, 1598, 1698, 1834, 1899, 1974, 2070, 2134, 2149, 2510, 2555, 2569, 2619, 2670, 2695, 2708, 2803, 2839, 2906, 3039, 3083, 3147, 3220, 3224, 3294, 3383, 3533, 3573, 3606, 3619, 3643, 3722, 3785, 3884, 3921, 4037, 4043, 4096, 4157], 'fibroblasts.': [41, 248, 290, 497, 1262, 1340, 2882], 'Angiotensin': [42, 291], 'II': [43, 72, 174, 217, 292, 321, 423, 466, 770, 1281, 1354, 1380, 2329, 2832, 2925, 2984, 3031, 3085, 3119, 3150, 3166, 3326, 3339, 3386, 3415, 3425, 3455, 3480, 3535, 3576, 3659, 3727, 3738, 3752, 3803, 3871, 4074], '(ANG': [44, 293, 3414, 3658], 'II)': [45, 294], 'activates': [46, 295, 1270, 1282, 3481, 3541, 3770], 'cell': [47, 296, 925, 1213, 1688, 1715, 2506], 'proliferation': [48, 297, 816, 873], 'but': [52, 165, 301, 414, 895, 1297, 3345, 3528, 3673, 3970, 4191, 4376], 'also': [53, 302, 771, 1130, 3960, 4229], 'potentiates': [54, 218, 303, 467, 1355, 2874], 'cyclic': [55, 304], 'AMP': [56, 305], '(cAMP)': [57, 306], 'production': [58, 69, 307, 318, 836, 1219, 1275, 1293, 1406, 1642, 2879, 3390, 3459, 3603, 3784, 3965, 4078, 4095], 'stimulated': [59, 308, 1124, 3072, 3293, 3782], 'β-adrenergic': [61, 310, 559, 1266], 'receptors': [62, 311, 627, 866, 1285], '(β-AR).': [63, 312], 'The': [64, 313, 516, 1315, 1341, 1585, 2120, 2164, 2471, 2487, 4099], 'potentiation': [65, 314, 1310, 1369, 3079, 3103, 3167, 3309, 3653, 4024, 4092], 'β-AR-stimulated': [67, 316], 'cAMP': [68, 97, 163, 219, 317, 346, 412, 468, 804, 835, 915, 1218, 1274, 1292, 1313, 1357, 1405, 1798, 1832, 1897, 2139, 2147, 2878, 2990, 3006, 3059, 3081, 3170, 3214, 3291, 3312, 3389, 3458, 3602, 3636, 3743, 3755, 3783, 3806, 3845, 3964, 3976, 4010, 4027, 4077, 4094], 'ANG': [71, 173, 198, 210, 216, 320, 422, 447, 459, 465, 545, 735, 769, 1280, 1353, 1379, 1384, 1446, 2831, 2868, 2924, 2983, 3030, 3084, 3118, 3149, 3165, 3299, 3307, 3325, 3338, 3385, 3424, 3454, 3479, 3534, 3575, 3651, 3726, 3737, 3751, 3802, 3870, 4061, 4073, 4097], 'is': [73, 180, 322, 429, 500, 805, 905, 1370, 2951, 3096, 3391, 3872, 4086, 4245], 'reduced': [74, 323, 3071], 'phospholipase': [76, 325, 578, 2901], 'C': [77, 326, 2841, 2902, 3709], 'inhibition': [78, 184, 327, 433, 1007, 3640], 'enhanced': [80, 329, 834, 3143, 3163, 3600, 3962], 'overexpression': [82, 331], 'Gq.': [84, 333], 'Ionomycin': [85, 334, 3630, 3740], 'thapsigargin': [87, 336], 'increased': [88, 161, 189, 205, 337, 410, 438, 454, 503], 'intracellular': [89, 338, 1349, 1402, 3537, 3589, 3730, 3886, 3912, 3923, 3934, 4034, 4084], 'Ca2+': [90, 102, 339, 351, 1350, 1403, 2152, 3527, 3538, 3584, 3590, 3731, 3890, 3894, 3909, 3935, 3956, 3992, 3998, 4045, 4063, 4085, 4106], 'levels': [91, 340, 3007, 3539, 3591, 3807, 3846, 3936], 'potentiated': [93, 342, 3034, 3804, 3843], 'isoproterenol-': [94, 343], 'forskolin-stimulated': [96, 345], 'production,': [98, 347], 'whereas': [99, 348, 4343], 'chelation': [100, 349], 'with': [103, 138, 352, 387, 502, 519, 978, 1300, 1378, 1523, 1705, 1753, 1809, 1817, 1836, 1860, 2005, 2194, 2377, 2559, 2701, 2714, 2727, 2738, 2778, 2913, 2923, 2933, 3178, 3182, 3200, 3296, 3355, 3405, 3434, 3579, 3615, 3704, 3773, 3798, 3968, 4015, 4020, 4049, 4102], '1,2-bis(2-aminophenoxy)ethane-N,N,N′,': [104, 353, 562], 'N′-tetraacetic': [105, 354, 563], 'acid/AM': [106, 355], 'inhibited': [107, 356, 1067, 1132, 3401], 'such': [108, 357, 726, 2230], 'potentiation.': [109, 358], 'Inhibitors': [110, 359], 'tyrosine': [112, 361, 3394, 3411, 3471, 3486], 'kinases,': [113, 362], 'protein': [114, 363, 553, 1013, 1069, 1189, 1934, 2065, 2538, 2698, 3484], 'kinase': [115, 364, 554, 1070, 1190, 3395, 3412, 3487, 3680], 'C,': [116, 365], 'or': [117, 366, 1006, 1550, 1852, 1906, 2351, 2504, 3061, 3286, 3433, 3470, 4040, 4226, 4365], 'Gβγ': [118, 367, 1178, 3221, 3250, 3255, 3469], 'did': [119, 166, 368, 415, 3055, 3304, 3346, 3632, 3674, 4192], 'not': [120, 167, 369, 416, 1290, 1794, 3056, 3305, 3400, 3443, 3633, 3713, 3733, 3994, 4193, 4207, 4221, 4330], 'alter': [121, 168, 370, 417, 1291, 3634], 'cross-talk.': [123, 372], 'Immunoblot': [124, 373, 2501], 'analyses': [125, 374, 2574], 'showed': [126, 375], 'prominent': [127, 376], 'expression': [128, 377, 775, 918, 1210, 1693, 1775, 1790, 3133, 3140, 4235, 4395], 'adenylyl': [130, 379, 550, 1725], 'cyclase': [131, 380, 909, 1726], '3': [132, 381, 2582, 2712], '(AC3),': [133, 382], 'a': [134, 383, 506, 923, 1053, 1212, 1250, 1265, 1308, 1503, 1536, 1681, 2009, 2030, 2199, 2283, 2427, 2550, 2596, 2941, 3002, 3068, 3348, 3409, 3438, 3593, 3790, 3812, 3938, 3945, 4044, 4252, 4397], 'Ca2+-activated': [135, 384], 'isoform,': [136, 385], 'along': [137, 386, 2679], 'AC2,': [139, 388, 4171, 4346], 'AC4,': [140, 389, 4173, 4347], 'AC5,': [141, 390, 4174], 'AC6,': [142, 391, 1017, 4175], 'AC7.': [144, 393], 'Of': [145, 394], 'those': [146, 395, 3448, 4016], 'isoforms,': [147, 396], 'only': [148, 397, 1574, 4352], 'AC3': [149, 398, 1128, 4323], 'AC5/6': [151, 400, 4325], 'proteins': [152, 401, 784, 2775], 'were': [153, 402, 1420, 1433, 1442, 1453, 1462, 1479, 1496, 1512, 1547, 1552, 1562, 1583, 1751, 1805, 1824, 1854, 1858, 1894, 1926, 1972, 2132, 2158, 2166, 2190, 2247, 2276, 2338, 2347, 2381, 2424, 2508, 2520, 2547, 2567, 2650, 2656, 2693, 2725, 2758, 2769, 2776, 2786, 2820, 3702, 3985, 4220], 'detected': [154, 403, 4309, 4337, 4351, 4362], 'caveolin-rich': [156, 405, 4249, 4295, 4385], 'fractions.': [157, 406, 4320], 'Overexpression': [158, 407], 'AC6': [160, 409], 'βAR-stimulated': [162, 411], 'accumulation': [164, 413, 588, 1833, 3060, 3082, 3146, 3292, 3313], 'size': [170, 419, 4225], 'potentiation,': [175, 424], 'suggesting': [176, 425], 'that': [177, 201, 215, 426, 450, 464, 629, 695, 809, 1057, 1345, 1367, 1546, 1680, 1780, 2231, 2523, 2867, 3070, 3091, 3203, 3207, 3453, 3478, 3598, 3796, 3866, 3878, 3997, 4023, 4105, 4154, 4165, 4219, 4254, 4394], 'AC': [181, 225, 430, 474, 974, 1208, 1427, 1940, 2293, 3771, 4116, 4125, 4142, 4237, 4240, 4374, 4388, 4401], 'isoform-specific.': [182, 431], 'Isoproterenol-mediated': [183, 432], 'serum-stimulated': [186, 435], 'from': [190, 439, 1422, 1435, 1443, 1455, 1468, 1481, 2278, 2298, 2431, 2476, 2482, 2529, 3911, 4000, 4017, 4031, 4318], '31': [191, 440], '48%': [193, 442], 'presence': [196, 208, 445, 457, 1842], 'II,': [199, 448, 546, 736, 1447, 2869], 'indicating': [200, 449, 3996], 'βAR-regulated': [202, 451], 'II.': [211, 460, 3300, 4098], 'These': [212, 461, 1064, 3088, 3445, 3863, 4012], 'data': [213, 462, 1343, 3089], 'indicate': [214, 463, 1344, 3452, 3865, 4022, 4104], 'via': [221, 470, 697, 831, 874, 1360, 2872, 3392, 3460, 3759, 3907], 'Ca2+-dependent': [222, 471], 'activation': [223, 472, 821, 3093, 3110, 3204, 3225, 3259, 3360, 3532, 3734], 'activity,': [226, 475], 'which': [227, 476, 739, 828, 1018, 1401, 3384, 3574, 3768, 3926], 'turn': [229, 478], 'attenuates': [230, 479], 'demonstrates': [234, 483], 'one': [235, 484], 'functional': [236, 485], 'consequence': [237, 486, 1329], 'hypertrophy': [499, 641], 'associated': [501, 518], 'mass,': [505], 'gradual': [507], 'decline': [508], 'contractile': [510], 'function': [511], 'eventual': [513], 'heart': [514, 723], 'failure.': [515], 'these': [520, 1334, 1588, 1856, 2961, 2997, 3983, 4146], 'changes': [521], 'involves': [522], 'an': [523, 1396, 1717, 2240, 2400, 2952, 3234, 3474, 3760], 'altered': [524, 2989], 'balance': [525], 'degradation': [529, 781], '(ECM)': [533], '1The': [534], 'abbreviations': [535], 'used': [536, 1710, 2339, 2409, 2995, 3124, 3233, 4203, 4328], 'are:': [537], 'ECM,': [538], 'matrix;': [540], 'GPCR,': [541], 'G': [542, 625, 3483], 'protein-coupled': [543, 626], 'receptors;': [544, 560], 'angiotensin': [547, 1284], 'II;': [548], 'AC,': [549], 'cyclase;': [551], 'PKC,': [552], 'C;': [555], 'ISO,': [556, 3417], 'isoproterenol;': [557], 'βAR,': [558, 3764], 'BAPTA,': [561], 'acid;': [564], 'DMEM,': [565], "Dulbecco's": [566, 1517], 'modified': [567, 1518, 2626], "Eagle's": [568, 1519], 'medium;': [569], 'FBS,': [570], 'fetal': [571, 1529], 'bovine': [572, 1530, 2111], 'serum;': [573], 'RT,': [574], 'reverse': [575, 2325, 4200], 'transcriptase;': [576], 'PLC,': [577], 'C.': [579, 1097, 1110, 1954, 2364, 4273], 'can': [584, 1129, 1183, 3880, 4029], 'lead': [585], 'abnormal': [587], 'ECM': [590, 783], 'interstitial': [593], 'space': [594], '(i.e.': [595], 'fibrosis)': [596], '(1Eghbali': [597], 'M.': [598, 949, 1091, 2444, 3506, 3547, 4277], 'Weber': [599, 2640], 'K.T.': [600, 609, 747, 2641], 'Mol.': [601, 617, 762, 1621, 1743, 1919, 2369, 2465, 3498, 4266], 'Cell.': [602, 763, 3499, 4283], 'Biochem.': [603, 942, 3500, 4284], '1990;': [604], '96:': [605, 750], '1-14Google': [606], 'Scholar,': [607, 673, 752, 851, 947, 1089, 1104, 1147, 1158, 3504, 4271], '2Weber': [608], 'Sun': [610], 'Y.': [611, 647, 653, 1028, 1233, 1651, 1657, 1958, 2851, 2968, 3016, 4281], 'Tyagi': [612, 2638], 'S.C.': [613, 2639], 'Cleutjens': [614], 'J.P.': [615], 'J.': [616, 686, 761, 795, 881, 888, 943, 990, 1045, 1079, 1093, 1098, 1106, 1137, 1160, 1165, 1195, 1241, 1963, 2447, 2859, 2976, 3024, 3272, 3373, 4282], 'Cell': [618, 1111], 'Cardiol.': [619, 764], '1994;': [620, 1048], '26:': [621], '279-292Google': [622], 'Scholar).': [623, 692, 716, 768, 799, 864, 970, 1000, 1116, 1171, 1205, 1626, 1677, 1748, 1924, 1969, 2374, 2470, 2647, 2981, 3029, 3278, 3379, 3521], 'Several': [624], '(GPCR)': [628], 'signal': [630, 696, 1222, 1257, 3678, 4028], 'through': [631, 820], 'have': [633, 867, 1247, 2865], 'been': [634, 868], 'implicated': [635], 'pathogenesis': [638], 'failure': [643], '(3Adams': [644, 1648], 'J.W.': [645, 1649, 1960], 'Sakata': [646, 1650], 'Davis': [648, 1652], 'M.G.': [649, 1653], 'Sah': [650, 676, 1654], 'V.P.': [651, 677, 1655], 'Wang': [652, 1656], 'Liggett': [654, 1658], 'S.B.': [655, 1659], 'Chien': [656, 682, 1660], 'K.R.': [657, 683, 1661], 'Brown': [658, 684, 1662], 'J.H.': [659, 685, 1663], 'Dorn': [660, 1664], '2nd,': [661, 1665], 'G.W.': [662, 1666, 3495], 'Proc.': [663, 960, 1667], 'Natl.': [664, 961, 1668], 'Acad.': [665, 962, 1669], 'Sci.': [666, 963, 1670], 'U.': [667, 964, 1671], 'S.': [668, 885, 953, 965, 1030, 1038, 1235, 1672, 1740, 1916, 2438, 2462, 2853, 2970, 3018, 3265, 3366, 3510, 3551, 4263, 4275], 'A.': [669, 966, 1095, 1108, 1673], '1998;': [670, 713, 967, 1674], '95:': [671, 968, 1675], '10140-10145Google': [672, 1676], '4Ramirez': [674], 'M.T.': [675], 'Zhao': [678], 'X.L.': [679], 'Hunter': [680], 'J.J.': [681], 'Biol.': [687, 889, 1099, 1166, 1964, 2448], 'Chem.': [688, 890, 1100, 1167, 1965, 2449], '1997;': [689, 749, 861, 3275, 3376], '272:': [690], '14057-14061Google': [691], 'Conversely,': [693, 3638, 4047], 'GPCRs': [694, 3206], 'may': [699], 'inhibit': [700, 813, 3649, 3918], 'deposition': [702], '(5Dubey': [706], 'R.K.': [707, 838], 'Gillespie': [708, 839], 'D.G.': [709, 840], 'Jackson': [710, 845], 'E.K.': [711, 846], 'Hypertension.': [712, 847, 860], '31:': [714, 1156], '943-948Google': [715], 'Two': [717], 'major': [718], 'pro-fibrotic': [719], 'signals': [720], 'are': [724, 1019, 1058, 1066, 1123, 1175, 2577, 3198, 4155], 'cytokines,': [725], 'as': [727, 1596, 1614, 1645, 1696, 1732, 1908, 1948, 2354, 2498, 2608, 3570, 4204], 'transforming': [728], 'growth': [729, 876], 'factor-β,': [730], 'peptide': [733, 3240, 3245], 'hormone': [734], 'both': [737, 3148, 3254, 3482, 3568, 4087], 'increase': [740, 1788, 3004, 3131, 3152, 3158, 3350], '(6Weber': [746], 'Circulation.': [748], '4065-4082Google': [751], '7Lee': [753], 'A.A.': [754], 'Dillmann': [755], 'W.H.': [756], 'McCulloch': [757], 'A.D.': [758, 883], 'Villarreal': [759, 1236, 2854, 2971, 3019], 'F.J.': [760, 1237, 2855, 2972, 3020], '1995;': [765, 796, 944], '27:': [766, 2645], '2347-2357Google': [767], 'inhibits': [772, 1383, 3253, 3927], 'metalloproteinase': [774], 'fibroblasts,': [778, 1296], 'thereby': [779], 'attenuating': [780], '(8Brilla': [785], 'C.G.': [786], 'Rupp': [787], 'H.': [788, 853], 'Funck': [789], 'R.': [790, 935, 957], 'Maisch': [791], 'B.': [792], 'Eur.': [793], 'Heart': [794], '16:': [797], '107-109Google': [798], 'An': [800], 'anti-fibrotic': [801], 'role': [802, 897, 3566], 'for': [803, 1601, 1606, 1641, 1691, 1826, 1831, 1847, 1862, 1896, 1928, 2019, 2040, 2124, 2136, 2146, 2186, 2662, 2689, 2762, 2782, 2791, 3098, 3523, 4053, 4091, 4170, 4213, 4322, 4363], 'supported': [806], 'evidence': [808], 'adenosine': [810], 'prostacyclin': [812], 'fibroblast': [815, 872, 1946], 'A2b': [823], 'prostanoid': [825], 'receptors,': [826], 'respectively,': [827, 3835], 'each': [829, 977, 1886, 2142, 2342, 2378, 2524, 2754], 'couple': [830], 'Gs,': [832], '(9Dubey': [837], 'Zacharia': [841], 'L.C.': [842, 2635], 'Mi': [843], 'Z.': [844, 1151], '2001;': [848, 997, 1086, 1144, 1202, 1966], '37:': [849], '716-721Google': [850], '10Yu': [852], 'Gallagher': [854], 'A.M.': [855, 1231, 2849, 2966, 3014], 'Garfin': [856], 'P.M.': [857], 'Printz': [858], 'M.P.': [859, 2446], '30:': [862], '1047-1053Google': [863], 'β-Adrenergic': [865], 'shown': [869, 4302], 'stimulate': [871], 'epidermal': [875], 'factor': [877], 'receptor': [878, 1267, 3393, 3876], 'transactivation': [879], '(11Kim': [880], 'Eckhart': [882], 'Eguchi': [884], 'Koch': [886, 3268, 3369], 'W.J.': [887, 3269, 3370], '2002;': [891, 2371], '277:': [892], '32116-32123Google': [893], 'Scholar)': [894, 1246, 2864], 'their': [896], 'regulating': [899], 'poorly': [906], 'documented.': [907], 'Adenylyl': [908], '(AC)': [910], 'catalyzes': [911], 'limits': [919, 1408], 'ability': [921], 'maximally': [927, 1721, 3951], 'produce': [928], 'second': [930, 2942], 'messenger': [931], '(12Post': [932], 'S.R.': [933], 'Hilal-Dandan': [934], 'Urasawa': [936], 'K.': [937, 1032, 1036], 'Brunton': [938, 1238, 1619, 2856, 2973, 3021], 'L.L.': [939, 1239, 1620, 2857, 2974, 3022], 'Insel': [940, 954, 1741, 1917, 1961, 2367, 2463, 4264], 'P.A.': [941, 955, 1742, 1918, 1962, 2368, 2464, 4265], '311:': [945], '75-80Google': [946], '13Gao': [948], 'Ping': [950], 'P.': [951], 'Post': [952], 'Tang': [956], 'Hammond': [958], 'H.K.': [959], '1038-1043Google': [969], 'Nine': [971], 'different': [972, 979], 'transmembrane': [973], 'isoforms': [975, 1022, 1065, 1428, 4126, 4143, 4153, 4375, 4378], 'exist,': [976], 'amino': [980], 'acid': [981, 1879, 1892, 2720, 2781], 'sequence,': [982], 'tissue': [983], 'chromosomal': [985], 'distribution,': [986], 'regulation': [988, 1003], '(14Hanoune': [989, 1078, 1136, 1194], 'Defer': [991, 1080, 1138, 1196], 'N.': [992, 1081, 1139, 1197], 'Annu.': [993, 1082, 1140, 1198], 'Rev.': [994, 1083, 1141, 1199], 'Pharmacol.': [995, 1084, 1142, 1200, 1622, 1744, 1920, 2370, 2466, 4267], 'Toxicol.': [996, 1085, 1143, 1201], '41:': [998, 1087, 1145, 1203], '145-174Google': [999, 1088, 1146, 1204], 'Differences': [1001], 'include': [1004], 'stimulation': [1005, 1361, 2922, 4059], 'Gβγ,': [1009, 1074], 'Ca2+,': [1010, 1072, 4035], 'various': [1012], 'kinases.': [1014], 'AC5': [1015, 4333], 'predominant': [1021], 'expressed': [1023, 4127, 4144], 'myocytes': [1026, 4244], '(15Ishikawa': [1027], 'Sorota': [1029], 'Kiuchi': [1031], 'Shannon': [1033], 'R.P.': [1034], 'Komamura': [1035], 'Katsushika': [1037], 'Vatner': [1039, 1041], 'D.E.': [1040, 3493], 'S.F.': [1042], 'Homcy': [1043], 'C.J.': [1044], 'Clin.': [1046, 3273, 3374], 'Invest.': [1047, 3274, 3375], '93:': [1049], '2224-2229Google': [1050], 'Scholar),': [1051, 2453, 3562, 4288], 'represent': [1052], 'subfamily': [1054], 'ACs': [1056], 'related': [1059], 'structure': [1061], 'regulation.': [1063], 'A,': [1071], 'Gi,': [1073], 'nitric': [1076], 'oxide': [1077], '16McVey': [1090], 'Hill': [1092], 'Howlett': [1094, 1107], 'Klein': [1096, 1109], '1999;': [1101, 4285], '274:': [1102], '18887-18892Google': [1103], '17Hill': [1105], 'Signal.': [1112], '2000;': [1113, 1243, 1623, 1745, 1921, 2467, 2861, 2978, 3026, 3518, 3559, 4268], '12:': [1114], '233-237Google': [1115], 'By': [1117], 'contrast,': [1118], 'AC1,': [1119], 'AC3,': [1120, 4172], 'AC8': [1122, 4178, 4364], 'Ca2+/calmodulin': [1126], '(yet': [1127], 'be': [1131, 1184, 2237, 3720, 4381], 'calmodulin': [1134], 'kinase-II)': [1135], '18Choi': [1148], 'E.J.': [1149], 'Xia': [1150], 'Storm': [1152, 1163], 'D.R.': [1153, 1164], 'Biochemistry.': [1154], '1992;': [1155], '6492-6498Google': [1157], '19Wei': [1159], 'Wayman': [1161], 'G.': [1162], '1996;': [1168, 2450, 3501], '271:': [1169, 2451], '24231-24235Google': [1170], 'AC2': [1172, 1180], 'AC4': [1174], 'activated': [1176, 1185], 'AC7': [1182, 4349], 'phosphorylation': [1187], 'A': [1191, 2312], 'and/or': [1192], 'PKC': [1193, 3542, 3642, 3706], 'Thus,': [1206, 1393, 3193, 3715, 4081, 4369], 'isoform': [1209, 2343, 4399], 'determines': [1214], 'interaction': [1216], 'other': [1221, 1458, 1938], 'transduction': [1223, 1258], 'cascades.': [1224], 'Meszaros': [1225], 'et': [1226, 2433, 2630, 2844], 'al.': [1227, 2434, 2631, 2845], '(20Meszaros': [1228, 2846, 2963, 3011], 'J.G.': [1229, 2847, 2964, 3012], 'Gonzalez': [1230, 2848, 2965, 3013], 'Endo-Mochizuki': [1232, 2850, 2967, 3015], 'Villegas': [1234, 2852, 2969, 3017], 'Am.': [1240, 2858, 2975, 3023], 'Physiol.': [1242, 2860, 2977, 3025, 3516, 3557], '278:': [1244, 2862, 2979, 3027], 'C154-C162Google': [1245, 2863, 2980, 3028], 'recently': [1248], 'described': [1249, 1616, 1647, 1733, 1909, 1950, 2356, 2455, 2866], '"cross-talk"': [1252], 'two': [1254, 1335], 'GPCR': [1256], 'Isoproterenol': [1263], '(ISO),': [1264], '(βAR)': [1268], 'agonist,': [1269], 'stimulates': [1273], '10-fold': [1276], 'over': [1277, 3153, 3159, 3174, 3190, 3323, 3421, 3665, 3787, 3832], 'basal': [1278, 3058, 3635, 3788, 3975], 'levels.': [1279], 'Gq-coupled': [1283], 'that,': [1286], 'themselves,': [1288], 'do': [1289], 'combination': [1299, 2932], 'ISO': [1301, 1382, 1391, 2934, 2999, 3038, 3049, 3063, 3175, 3191, 3295, 3319, 3328, 3334, 3341, 3352, 3422, 3427, 3616, 3656, 3661, 3666], 'potentiate': [1302], 'βAR': [1304, 2834, 2875, 3121], 'response,': [1305, 3064], 'resulting': [1306, 2475, 2532], '2-fold': [1309, 3831], 'ISO-stimulated': [1312, 3169, 3311, 3754], 'production.': [1314, 3637, 3977], 'goal': [1316], 'present': [1319], 'study': [1320], 'was': [1321, 1590, 1634, 1689, 1791, 1871, 1882, 1942, 2013, 2026, 2044, 2068, 2122, 2144, 2259, 2270, 2296, 2315, 2324, 2408, 2480, 2496, 2593, 2622, 2667, 2706, 2751, 2801, 2897, 3399, 3950, 4003, 4202, 4308, 4316, 4336, 4350, 4361, 4402], 'identify': [1323, 1395], 'molecular': [1325], 'mechanism': [1326], 'physiological': [1328], 'current': [1342], 'Gq-mediated': [1346], 'elevation': [1347, 4032, 4082], 'induced': [1351], 'Gs-stimulated': [1356], 'formation,': [1358], 'probably': [1359], 'AC3.': [1363], 'Moreover,': [1364], 'show': [1366], 'functionally': [1371], 'relevant:': [1372], 'combined': [1373], 'treatment': [1374], 'II-promoted': [1385], 'more': [1388], 'so': [1389, 2522], 'than': [1390, 1592, 3468, 4114], 'alone.': [1392], 'endogenous': [1397], 'pathway': [1399, 2959, 3382], 'enhances': [1404, 3456], 'synthesis,': [1410], 'perhaps': [1412, 2870], 'fibrosis,': [1413], 'heart.': [1416], 'Materials—Cell': [1417], 'culture': [1418, 1543], 'reagents': [1419, 1461], 'obtained': [1421, 1434, 1454, 1467, 3979], 'Invitrogen.': [1423], 'Primary': [1424], 'antibodies': [1425, 1432, 2566], 'all': [1430, 2415], 'secondary': [1431], 'Santa': [1436], 'Cruz': [1437], 'Biotechnology.': [1438], 'Antibodies': [1439], 'caveolin': [1441], 'BD': [1444], 'Pharmingen.': [1445], 'UTP,': [1448, 3689], 'Fura-2/AM,': [1449], 'forskolin,': [1450, 3767], 'BAPTA/AM': [1452, 4052], 'Calbiochem.': [1456], 'All': [1457], 'drugs': [1459, 1837, 2117, 2683], 'reagent': [1464, 2310], 'grade': [1465], 'Sigma.': [1469], 'Preparation': [1470], 'Culture': [1472], 'Adult': [1474], 'Rat': [1475], 'Fibroblasts—Cardiac': [1477], 'prepared': [1480, 1973], 'adult': [1482], 'male': [1483], '250–300-g': [1484], 'Sprague-Dawley': [1485], 'rat': [1486, 2350], 'hearts.': [1487], 'Following': [1488], 'rapid': [1489, 3955], 'excision': [1490], 'hearts,': [1493], 'ventricles': [1495], 'isolated,': [1497], 'minced,': [1498], 'pooled,': [1499], 'placed': [1501, 2197, 2771], 'collagenase/pancreatin': [1504], 'digestion': [1505], 'solution.': [1506], 'After': [1507, 1535, 1557], 'sequential': [1508], 'digestions,': [1509], 'pelleted': [1513, 2707], 'resuspended': [1515], 'medium': [1520, 1870], '(DMEM)': [1521], 'supplemented': [1522, 1816], 'penicillin,': [1524], 'streptomycin,': [1525], 'fungizone,': [1526], '10%': [1528, 2779], 'serum': [1531, 2112, 2657], '(FBS,': [1532], 'Gemini': [1533], 'Bio-Products).': [1534], '30-min': [1537], 'period': [1538], 'attachment': [1540], 'uncoated': [1542], 'plates,': [1544], 'cells': [1545, 1578, 1861, 1976, 1984, 2165, 2235, 2649, 2962, 3180, 3403, 4147], 'weakly': [1548], 'attached': [1549], 'unattached': [1551], 'rinsed': [1553], 'free': [1554, 3249], 'discarded.': [1556], '2–3': [1558], 'days,': [1559], 'confluent': [1560], 'cultures': [1561, 1589], 'amplified': [1563, 4186], 'trypsinization': [1565, 2696], 'seeding': [1567], 'onto': [1568], 'new': [1569], 'dishes.': [1570], 'For': [1571], 'assays,': [1573], 'early': [1575], 'passage': [1576], '(≤3)': [1577], 'grown': [1579, 2301], '80–90%': [1581, 2303], 'confluency': [1582, 2304], 'used.': [1584], 'purity': [1586], 'greater': [1591], '95%': [1593], 'determined': [1597, 1697, 2802], 'positive': [1599], 'staining': [1600, 1605, 1778], 'vimentin': [1602], 'negative': [1604, 3700], 'smooth': [1607], 'muscle': [1608], 'actin': [1609], 'von': [1611], 'Willebrand': [1612], 'factor,': [1613], 'previously': [1615, 1646, 1734, 1910, 1949, 2355, 2456], '(21Gustafsson': [1617], 'A.B.': [1618], '58:': [1624], '1470-1478Google': [1625], 'Adenoviral': [1627], 'Gene': [1628], 'Transfer': [1629], 'Fibroblasts—Wild-type': [1632], 'cloned': [1635], 'into': [1636, 1985, 2076], 'PACCMVpLpA': [1638], 'shuttle': [1639], 'vector': [1640], 'adenovirus,': [1644], 'We': [1678, 1709, 2909, 3279, 3581, 3978, 4228], 'found': [1679], 'titer': [1682], '200': [1684], 'virus': [1685, 1756, 3186, 3288], 'particles': [1686, 1713], 'per': [1687, 1714, 1935], 'optimal': [1690], 'without': [1694, 3298], 'cytotoxicity,': [1695], 'trypan': [1699], 'blue': [1700], 'exclusion': [1701], 'morphological': [1703], 'examination': [1704], 'phase-contrast': [1706], 'light': [1707], 'microscopy.': [1708], '1000': [1711], 'viral': [1712], 'adenovirus': [1718, 3235], 'construct': [1719, 1786], 'overexpress': [1722], 'murine': [1724, 2352], 'type': [1727], '6': [1728], '(AC6)': [1729], 'gene,': [1730], 'produced': [1731], '(22Ostrom': [1735, 1911, 2457, 4258], 'R.S.': [1736, 1912, 1952, 2358, 2458, 4259], 'Violin': [1737, 1913, 2459, 4260], 'J.D.': [1738, 1914, 2460, 4261], 'Coleman': [1739, 1915, 2461, 4262], '57:': [1746, 1922, 2468, 4269], '1075-1079Google': [1747, 1923, 2469, 4270], 'infected': [1752], 'appropriate': [1755, 4187], 'incubated': [1758, 2123, 2173, 2910, 3181], 'at': [1759, 2015, 2022, 2036, 2127, 2183, 2261, 2272, 2580, 2765, 2788, 3824, 3944, 4108], '37': [1760, 1810, 2184, 2200, 2766], '°C': [1761, 1811, 2129, 2185, 2201], '18–24': [1762], 'h': [1763, 2764], 'serum-free': [1765, 1812], 'DMEM': [1766, 1815, 2178, 2195], 'prior': [1767, 2919, 4056], 'assays.': [1770], 'Preliminary': [1771], 'experiments': [1772, 2888, 3984], 'using': [1773, 2239, 2249, 2308, 2327, 2396, 2426, 2595, 2822, 3623, 4161, 4211], 'LacZ': [1774], 'β-galactosidase': [1777], 'indicated': [1779], 'efficiency': [1782], 'adenoviral': [1785], 'gene': [1789, 3126], '40%': [1792], '(data': [1793, 3442, 3712, 3993, 4206], 'shown).': [1795, 3444, 3714, 4208], 'Quantitation': [1796], 'Production—Cardiac': [1799], 'cultured': [1801], '24-well': [1803], 'plates': [1804, 2307, 2654], 'washed': [1806, 2167, 2192, 2711], 'three': [1807], 'times': [1808, 2713], 'NaHCO3-free': [1814], '20': [1818, 2006], 'mm': [1819, 1845, 1990, 1993, 1996, 1999, 2050, 2053, 2056, 2082, 2085, 2088, 2091, 2094, 2097, 2100, 2211, 2214, 2217, 2220, 2223, 2226], 'HEPES,': [1820, 2227], 'pH': [1821, 2001, 2058, 2114, 2228, 2737], '7.4.': [1822], 'Cells': [1823, 2189, 2692], 'equilibrated': [1825, 1859], '30': [1827, 2072, 2128, 2187, 4054], 'min,': [1828], 'then': [1829, 1982, 2027, 2191, 2655, 2668, 2770], 'assayed': [1830, 1895, 2145, 2669], 'incubation': [1835], 'interest': [1839, 2685], '0.2': [1844, 2728, 2739], 'isobutylmethylxanthine': [1846], '10': [1848, 2041, 2090, 2099, 2216, 2792, 3624, 3825], 'min.': [1849, 2042, 2138, 2188], 'When': [1850], 'antagonists': [1851], 'inhibitors': [1853, 3707], 'used,': [1855], 'agents': [1857], '15': [1863, 2125], 'min': [1864, 2021, 2126, 2793, 4055], 'before': [1865], 'addition': [1866], 'agonists.': [1868], 'Assay': [1869, 2067, 2613], 'aspirated': [1872], '250': [1874], 'μl': [1875, 2073], 'ice-cold': [1877, 1979], 'trichloroacetic': [1878, 2703, 2719, 2780], '(7.5%': [1880], 'w/v)': [1881], 'immediately': [1883], 'added': [1884, 2752], 'well': [1887], 'terminate': [1889], 'reactions.': [1890], 'Trichloroacetic': [1891], 'extracts': [1893], 'content': [1898, 2140, 2148], 'either': [1900, 3284, 4036], 'Direct': [1901], 'ELISA': [1902], 'kit': [1903], '(Assay': [1904], 'Designs)': [1905], 'radioimmunoassay': [1907], 'Data': [1925], 'corrected': [1927], 'amount': [1930], 'total': [1932, 2064], 'acid-precipitable': [1933], 'well.': [1936], 'studies,': [1939], 'activity': [1941, 2904], 'measured': [1943, 2623, 3290], 'membranes': [1947, 1971, 2075], '(23Ostrom': [1951], 'Gregorian': [1953, 2363], 'Drenan': [1955], 'R.M.': [1956], 'Xiang': [1957], 'Regan': [1959], '276:': [1967], '42063-42069Google': [1968], 'Briefly,': [1970, 2648], 'rinsing': [1975], 'twice': [1977], 'phosphate-buffered': [1980, 2170], 'saline': [1981, 2171, 2208], 'scraping': [1983], 'hypotonic': [1986], 'homogenizing': [1987, 2004], 'buffer': [1988, 2048, 2080, 2750], '(30': [1989, 2049, 2081, 2929], 'Na-HEPES,': [1991, 2051, 2083], '5': [1992, 2020, 2052, 2102, 2137, 2213], 'MgCl2,': [1994, 2054, 2092, 2221], '1': [1995, 2087, 2093, 2096, 2175, 2180, 2219, 2672, 2763, 2783, 3197, 3451, 4050], 'EGTA,': [1997, 2089], '2': [1998, 2055], 'dithiothreitol,': [2000, 2057], '7.5)': [2002, 2059, 2115], 'strokes': [2007], 'Dounce': [2010], 'homogenizer.': [2011], 'Homogenate': [2012], 'spun': [2014, 2035], '300': [2016], '×': [2017, 2038, 2155], 'g': [2018, 2039], '4': [2023, 2489], '°C.': [2024, 2405, 2767], 'Supernatant': [2025], 'transferred': [2028, 2548, 2651], 'clean': [2031], 'centrifuge': [2032], 'tube': [2033, 2143, 2755], '5,000': [2037], 'Pellet': [2043], 'suspended': [2045], 'membrane': [2047, 2543, 2553, 4341, 4355, 4386], 'attain': [2061], '∼1': [2062], 'mg/ml': [2063], 'concentration.': [2066], 'conducted': [2069, 4230], 'adding': [2071, 2671], 'tubes': [2077], 'containing': [2078, 2179, 2203], 'assay': [2079], '100': [2084, 3626, 3687, 3827, 3948], 'NaCl,': [2086, 2212], 'isobutylmethylxanthine,': [2095], 'ATP,': [2098], 'phosphocreatine,': [2101], 'μm': [2103, 2181, 3688, 3800, 4051], 'GTP,': [2104], '60': [2105], 'units/ml': [2106], 'creatine': [2107], 'phosphokinase,': [2108], '0.1%': [2110], 'albumin,': [2113], 'interest.': [2119], 'mixture': [2121], 'reactions': [2131, 2376, 4210], 'stopped': [2133], 'boiling': [2135], 'radioimmunoassay.': [2150], 'Intracellular': [2151, 3526], 'Measurements—Fibroblasts': [2153], '(0.25': [2154], '105': [2156], 'cells)': [2157], 'plated': [2159], '22-mm': [2161], 'glass': [2162], 'coverslips.': [2163], 'once': [2168, 2193], 'ml': [2176, 2205, 2490, 2716], 'Fura-2/AM': [2182], 'chamber': [2202], '1.5': [2204, 2287], 'HEPES-buffered': [2207], '(HBS:': [2209], '130': [2210], 'KCl,': [2215], 'glucose,': [2218], '1.0': [2222, 2715], 'CaCl2,': [2224], '25': [2225], '7.4),': [2229], 'groups': [2232], '5–8': [2234], 'could': [2236, 3387, 3917, 4131], 'viewed': [2238], 'inverted': [2241], 'Olympus': [2242], 'IX-70': [2243], 'microscope.': [2244], 'Spectrofluorometric': [2245], 'measurements': [2246], 'collected': [2248, 2271, 2481, 2497], 'Delta': [2250], 'Scan': [2251], 'System': [2252], 'spectofluorometer': [2253], '(Photon': [2254], 'Technology),': [2255], 'where': [2256, 2681], 'field': [2258], 'excited': [2260], '380': [2262], '340': [2264], 'nm': [2265, 3627, 3828, 3949], 'emission': [2268], 'ratio': [2269], '511': [2273], 'nm.': [2274], 'Agonists': [2275], 'administered': [2277], '×1000': [2279], 'stocks': [2280], 'maintain': [2282], 'constant': [2284], 'volume': [2285], 'ml.': [2288], 'Reverse': [2289], 'Transcriptase-PCR': [2290], 'Identify': [2292], 'Isoforms—Total': [2294], 'RNA': [2295, 2323, 4198], 'extracted': [2297], '15-cm': [2306], 'Trizol': [2309], '(Invitrogen).': [2311], 'DNase': [2313], 'reaction': [2314], 'performed': [2316, 2382, 2821, 3986, 4298], 'eliminate': [2318], 'DNA': [2319, 2387, 4189], 'contaminants': [2320], 'transcribed': [2326], 'Superscript': [2328], '(Invitrogen)': [2330], 'poly-T': [2332], 'priming.': [2333], 'Individual': [2334], 'isoform-selective': [2335], 'primer': [2336, 2379, 4184], 'pairs': [2337, 4185], 'amplify': [2341], 'AC.': [2345], 'Primers': [2346], 'based': [2348], 'sequences': [2353], '(24Ostrom': [2357], 'Liu': [2359], 'X.': [2360], 'Head': [2361], 'B.P.': [2362], 'Seasholtz': [2365], 'T.M.': [2366], '62:': [2372], '983-992Google': [2373], 'PCR': [2375, 2416, 4195, 4209], 'pair': [2380], 'cDNA': [2384], 'template,': [2385], 'genomic': [2386, 4188], '(positive': [2388], 'control),': [2389], 'minus': [2391], 'RT': [2392], '(negative': [2393], 'control)': [2394, 3154, 3160], 'template': [2395, 4205], '35': [2397], 'cycles': [2398], 'annealing': [2401], 'temperature': [2402], '56': [2404], 'Sequence': [2406], 'analysis': [2407, 2815, 4160, 4232], 'confirm': [2411], 'identity': [2413, 4123], 'products.': [2417], 'Purification': [2418], 'Caveolin-enriched': [2420], 'Membrane': [2421], 'Fractions—Cardiac': [2422], 'fractionated': [2425, 4290], 'detergent-free': [2428], 'method': [2429], 'adapted': [2430], 'Song': [2432], '(25Song': [2435], 'S.K.': [2436], 'Li': [2437], 'Okamoto': [2439], 'T.': [2440], 'Quilliam': [2441], 'L.A.': [2442], 'Sargiacomo': [2443], 'Lisanti': [2445], '9690-9697Google': [2452], 'faint': [2472], 'light-scattering': [2473], 'band': [2474], 'sucrose': [2477, 2485], 'density': [2478, 2590, 2611], 'centrifugation': [2479, 2709], '5–35%': [2484], 'interface.': [2486], 'bottom': [2488], 'gradient': [2493], '(45%': [2494], 'sucrose)': [2495], 'non-caveolar': [2499], 'membranes.': [2500], 'Analysis—Individual': [2502], 'fractions': [2503, 2519, 4250, 4296, 4312, 4356], 'whole': [2505], 'lysates': [2507], 'separated': [2509], 'SDS-polyacrylamide': [2511], 'gel': [2512], 'electrophoresis': [2513], '(Nu-PAGE,': [2514], 'Invitrogen).': [2515], 'Equal': [2516], 'volumes': [2517], 'loaded': [2521, 2539], 'lane': [2525], 'represents': [2526], 'similar': [2527, 3794, 3980], 'proportions': [2528], 'cells,': [2531], '∼10-fold': [2534], 'lower': [2535], 'amounts': [2536], 'caveolin-enriched': [2542, 4340], 'fraction': [2544], 'lanes.': [2545], 'Proteins': [2546], 'polyvinylidene': [2551], 'difluoride': [2552], '(Millipore)': [2554], 'electroblotting': [2556], 'probed': [2558], 'primary': [2560, 2565], 'antibody': [2561, 4327], '(see': [2562], '"Materials").': [2563], 'Bound': [2564], 'visualized': [2568], 'chemiluminescence.': [2570], 'Images': [2571], 'immunoblot': [2573, 4231, 4299], 'RT-PCR': [2576, 4159], 'representative': [2578], 'least': [2581], 'separate': [2583], 'experiments.': [2584], 'some': [2586, 3774], 'experiments,': [2587, 2998], 'optical': [2589, 2610], 'bands': [2592], 'calculated': [2594], 'digital': [2597], 'imaging': [2598], 'system': [2599], 'LabWorks': [2601], 'software': [2602], '(UVP': [2603], 'Bioimaging': [2604], 'Systems)': [2605], 'reported': [2607], 'arbitrary': [2609], 'units.': [2612], 'Collagenase-sensitive': [2615], '[3H]Proline': [2616], 'Incorporation—[3H]Proline': [2617], 'incorporation': [2618, 2666], 'according': [2624], 'methods': [2627], 'Guarda': [2629], '(26Guarda': [2632], 'E.': [2633, 3508, 3549], 'Katwa': [2634], 'Myers': [2636], 'P.R.': [2637], 'Cardiovasc.': [2642], 'Res.': [2643], '1993;': [2644], '2130-2134Google': [2646], '12-well': [2653], 'starved': [2658], '0%': [2660], 'FBS': [2661, 2688], '24': [2663, 2690], 'h.': [2664, 2691, 2784], 'Proline': [2665], 'μCi/well': [2673], '[3H]proline': [2675, 2797], '(PerkinElmer': [2676], 'Life': [2677], 'Sciences)': [2678], 'with,': [2680], 'indicated,': [2682], '2.5%': [2687], 'removed': [2694], 'precipitated': [2699, 2777], 'overnight': [2700], '20%': [2702], 'acid.': [2704], 'Protein': [2705], '5%': [2718], '+': [2721, 3327, 3340, 3416, 3426, 3428, 3660, 3694], '0.01%': [2722], 'proline.': [2723], 'Pellets': [2724], 'dissolved': [2726], 'm': [2729, 2740], 'NaOH': [2730], 'solutions': [2733], 'titrated': [2734], 'neutral': [2736], 'HCl.': [2741], 'Collagenase': [2742], '(2': [2743], 'mg/ml:': [2744], 'Worthington': [2745], 'Biochemical': [2746], 'Corp.)': [2747], 'Tris/CaCl2/N-ethymaleimide': [2749], 'samples': [2757], 'allowed': [2759], 'incubate': [2761], 'Samples': [2768, 2785], 'ice': [2773], 'centrifuged': [2787], '14,000': [2789], 'rpm': [2790], 'collagenase-sensitive': [2796], 'supernatant': [2800], 'liquid': [2804], 'scintillation': [2805], 'counting.': [2806], 'Analysis': [2807], 'Data—Statistical': [2809], 'comparisons': [2810], '(t': [2811], 'tests': [2812], 'one-way': [2814], 'variance)': [2817], 'graphics': [2819], 'Graph': [2823], 'Pad': [2824], 'Prism': [2825], '3.0': [2826], '(GraphPad': [2827], 'Software).': [2828], 'Cross-talk': [2829], 'Signaling': [2835], 'Pathways': [2836], 'Is': [2837], 'Mediated': [2838], 'Phospholipase': [2840], 'Gq—Meszaros': [2843], 'acting': [2871], 'Gq,': [2873], 'Gs-mediated': [2877], 'first': [2885], 'series': [2886], 'assessed': [2890], 'whether': [2891, 3109, 3218, 3746, 3902], 'dependent': [2898], 'upon': [2899, 3776], 'Gq-promoted': [2900, 3908], '(PLC)': [2903], '(promoted': [2905], 'activation).': [2908], 'specific': [2915, 3410, 4134], 'PLC': [2916, 3095, 3211, 3466], 'inhibitor,': [2917], 'U73122,': [2918], 'hormonal': [2921], '(100': [2926, 3840], 'nm)or': [2927], 'UTP': [2928, 2939, 2986, 3033, 3156, 3693], 'μm)': [2930, 3646, 3780], '(1': [2935, 3436, 3779], 'μm,': [2936], 'Fig.': [2937, 3196, 3450, 3836, 3861, 4304], '1).': [2938], 'provides': [2940], 'class': [2943], 'agonist': [2945, 4058], 'assess': [2947, 3108, 4152], 'because': [2949], 'it': [2950], 'efficacious': [2953, 3952], 'activator': [2954], 'Gq/PLC/inositol': [2957], 'trisphosphate': [2958], 'Neither': [2982], 'nor': [2985], 'alone': [2987, 3054, 3617, 3631, 3781, 3851], 'caused': [2988], 'accumulation.': [2991], 'At': [2992], 'concentration': [2994, 3069, 3946, 3959], 'routinely': [3000], 'produces': [3001], '10–12-fold': [3003], 'response': [3036, 3657, 3793], '1.8': [3040], '±': [3041, 3045, 3172, 3188, 3321, 3330, 3336, 3343, 3419, 3431, 3608, 3612, 3663, 3671, 3684, 3691, 3697, 3849, 3854], '0.1': [3042], '2.0': [3044, 3418, 3430, 3662], '0.1-fold': [3046, 3420, 3664], '(relative': [3047], 'alone),': [3050], 'respectively.': [3051, 3629], 'Whereas': [3052], 'U73122': [3053], 'affect': [3057], 'inhibitor': [3066, 3413, 3441], '(at': [3067], 'phosphoinositide': [3073], 'hydrolysis': [3074], '75–80%)': [3075], 'completely': [3076], 'eliminated': [3077], 'UTP.': [3087], 'suggest': [3090], 'Gq-linked': [3092], 'required': [3097], 'effect': [3100, 3388, 3724, 3761, 3868, 3883], 'Gs-AC': [3105], 'activity.': [3106], 'To': [3107, 3216], 'might': [3113, 3757, 3905], 'mediate': [3114], 'effects': [3116, 3749, 3973, 4071], 'signaling,': [3122, 3473], 'adenoviral-mediated': [3125], 'transfer': [3127], '(Fig.': [3137, 3596, 3604, 3941, 3966, 4065, 4079, 4179, 4357, 4367], '1B).': [3138], 'Increased': [3139], 'inositol': [3144], 'phosphate': [3145], '(1.6-fold': [3151], '(2.6-fold': [3157], 'significantly': [3162, 3842], '(3.9': [3171], '0.5-fold': [3173], 'alone)': [3176, 3810], 'compared': [3177, 3614], 'control': [3179], 'null': [3184, 3287], '(PACCMVpLpA)': [3185], '(2.5': [3187], '0.3-fold': [3189], 'alone).': [3192], 'results': [3194, 3701, 3864, 3981, 4100], 'consistent': [3199, 3354], 'conclusion': [3202], 'activate': [3208], 'enhance': [3212], 'βAR/Gs-mediated': [3213], 'formation.': [3215, 4011], 'determine': [3217, 3901], 'subunits': [3222], 'generated': [3223], 'mediates': [3228], 'observed': [3230], 'cross-talk,': [3231], 'express': [3237, 4168, 4372], 'C-terminal': [3239], 'GRK2': [3242, 3258, 3359], '(βARK1).': [3243], 'This': [3244], '(βARKct)': [3246], 'binds': [3247], 'subunits,': [3251], '(27Drazner': [3260, 3361], 'M.H.': [3261, 3362], 'Peppel': [3262, 3363], 'K.C.': [3263, 3364], 'Dyer': [3264, 3365], 'Grant': [3266, 3367], 'A.O.': [3267, 3368], 'Lefkowitz': [3270, 3371], 'R.J.': [3271, 3372], '99:': [3276, 3377], '288-296Google': [3277, 3378], 'exposed': [3280], 'βARKct': [3285, 3303, 3332], 'Expression': [3301, 4118], 'attenuate': [3306], 'II-induced': [3308, 3652, 4062], '(null': [3317], 'virus:': [3318, 3333], '10.8': [3320], '0.2-fold': [3322], 'basal,': [3324], '19.4': [3329], '2.2;': [3331], '9.2': [3335], '0.5,': [3337], '20.8': [3342], '0.6)': [3344], 'induce': [3347], '4-fold': [3349], 'potency,': [3353], 'action': [3357, 3462], 'blocking': [3358], 'Another': [3380], 'possible': [3381], 'signaling.': [3396], 'However,': [3397], 'treated': [3404], 'AG1478': [3406, 3429], '(10': [3407, 3645], 'μm),': [3408, 3437], 'alone;': [3423], '0.1)': [3432, 3672], 'PP2': [3435], 'selective': [3439], 'Src': [3440], 'findings': [3446], 'ISO-mediated': [3457], 'rather': [3467, 4113], 'kinase-associated': [3472], 'important': [3475], 'distinction': [3476], 'given': [3477], '(28Dostal': [3492], 'Booz': [3494], 'Baker': [3496], 'K.M.': [3497], '157:': [3502], '15-21Google': [3503], '29Hou': [3505], 'Pantev': [3507, 3548], 'Moller': [3509, 3550], 'Erlinge': [3511, 3552], 'D.': [3512, 3553], 'Edvinsson': [3513, 3554], 'L.': [3514, 3555], 'Acta': [3515, 3556], 'Scand.': [3517, 3558], '168:': [3519, 3560], '301-309Google': [3520, 3561], 'Requirement': [3522], 'Elevation': [3524], 'Not': [3529], 'PKC—Because': [3530], 'elevates': [3536], '(29Hou': [3546], 'examined': [3564], 'responses': [3569], 'potential': [3571], 'mechanisms': [3572], 'influences': [3577], 'Gs.': [3580], 'utilized': [3582, 3766], 'ionophore,': [3585], 'ionomycin,': [3586, 3628, 4021], 'elevate': [3588, 3729], 'concentration-dependent': [3594, 3813, 3939], 'manner': [3595, 3814, 3940, 4253], '2A)': [3597], 'synergistically': [3599, 3961], 'ISO-induced': [3601], '2B)': [3605], '2.7': [3607], '0.4': [3609], '4.0': [3611], '0.9-fold': [3613], '(indicated': [3618], 'dashed': [3621], 'line)': [3622], 'pharmacological': [3639], 'GF109203X': [3644, 3669], 'failed': [3647], 'alone,': [3667, 3834], 'plus': [3668], '1.9': [3670], 'reduce': [3675], 'UTP-stimulated': [3676], 'phosphoextracellular': [3677], 'regulated': [3679, 4156], 'immunoreactivity': [3681, 4241, 4307, 4360], '(basal,': [3682], '36': [3683], '6.1': [3685], 'OD;': [3686], '1037': [3690], '41;': [3692], 'GF109203X,': [3695], '180': [3696], '14.4).': [3698], 'Similar': [3699], 'seen': [3703, 3797, 4101], 'calphostin': [3708], 'staurosporine': [3711], 'Gq/Gs': [3716], 'appears': [3718], 'mediated': [3721], 'PKC.': [3736], 'Potentiate': [3741], 'Forskolin-induced': [3742], 'Production—To': [3744], 'test': [3745], 'synergistic': [3748, 4070], 'occur': [3758, 3906, 4030], 'distal': [3762, 3873], 'directly': [3769], '(albeit': [3772], 'dependence': [3775], 'Gs).': [3777], 'Forskolin': [3778], '8–10-fold': [3786], 'levels,': [3789], 'level': [3791, 4110], '0.1–1': [3799], 'ISO.': [3801], 'forskolin-induced': [3805, 3844, 3963], '(over': [3808], 'forskolin': [3809, 3833, 4103], 'range': [3817], 'tested': [3818], '(1–100': [3819], 'nm),': [3820], 'reaching': [3821], 'statistical': [3822], 'significance': [3823], '(1.6': [3829], '3A).': [3837], 'Likewise,': [3838], 'ionomycin': [3839, 3879], 'nm)': [3841], '(from': [3847], '8.3': [3848], '1.3-fold': [3850], '25.5': [3853], '7.4-fold': [3855], 'combination,': [3857], 'relative': [3858], 'controls,': [3860], '3B).': [3862], 'mimic': [3881], 'elevating': [3885], 'Ca2+.': [3887, 3924, 4158], 'Effects': [3888], 'Store': [3891], 'Release': [3892], 'Buffering': [3895], 'Gq-GsCross-talk—We': [3897, 4392], 'next': [3898], 'Gq-Gs': [3903], 'release': [3910, 3999, 4039], 'stores': [3913, 4002], 'if': [3915], 'buffering': [3922], 'Thapsigargin,': [3925], 'sarcoendoplasmic': [3929], 'reticular': [3930], 'Ca2+-ATPase': [3931], 'pump,': [3932], 'elevated': [3933], '4A).': [3942], 'Thapsigargin': [3943], 'stimulating': [3954], 'release;': [3957], '4B)': [3967], 'slight': [3969], 'statistically': [3971], 'insignificant': [3972], 'when': [3982, 4197], 'absence': [3989], 'shown),': [3995], 'internal': [4001], 'sufficient': [4004, 4090], 'observe': [4006], 'enhancement': [4008], 'results,': [4013], 'together': [4014], 'studies': [4019], 'storage': [4038], 'influx': [4041], 'promoted': [4042], 'ionophore.': [4046], 'preincubation': [4048], 'prevented': [4060], 'transients': [4064], '4C)': [4066], 'blocked': [4068], 'forskolin-mediated': [4076], '4D).': [4080], 'necessary': [4088], 'works': [4107], 'Gs/AC': [4112], 'βAR.': [4115], 'Isoform': [4117, 4389], 'Fibroblasts—Because': [4121], 'result': [4132], 'characteristics,': [4136], 'define': [4140], 'particular': [4150], 'isoform-specific': [4162], 'primers': [4163, 4212], 'revealed': [4164], 'mRNA': [4169], 'AC7,': [4176], '5A).': [4180], 'Each': [4181], 'sequence': [4190], 'yield': [4194], 'products': [4196, 4218], '(no': [4199], 'transcriptase)': [4201], 'AC1': [4214], 'AC9': [4216, 4366], 'yielded': [4217], 'expected': [4224], 'sequence.': [4227], 'detect': [4234], 'proteins.': [4238], 'Because': [4239], 'enriched': [4246], 'buoyant,': [4248], 'improves': [4255], 'immunological': [4256], 'detection': [4257], '30Schwencke': [4272], 'Okumura': [4274], 'Yamamoto': [4276], 'Geng': [4278], 'Y.J.': [4279], 'Ishikawa': [4280], '75:': [4286], '64-72Google': [4287], 'isolate': [4294], 'analyses.': [4300], 'As': [4301], '5B,': [4305], 'caveolin-1': [4306], 'buoyant': [4311], '(caveolin-rich': [4313], 'fraction)': [4314], 'excluded': [4317], 'non-buoyant': [4319], 'Immunoreactivity': [4321], '(the': [4326], 'does': [4329], 'distinguish': [4331], 'AC6)': [4335], 'primarily': [4338], 'fractions,': [4342], 'immunore-activity': [4344], 'non-caveolin-enriched': [4354], '5B).': [4358, 4368], 'No': [4359], 'numerous': [4373], 'appear': [4379], 'differentially': [4382], 'localized': [4383], 'microdomains.': [4387], 'Specificity': [4390], 'hypothesized': [4393], 'Ca2+-calmodulin-stimulable': [4398], 'ess': [4403]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2057817131', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2025-01-17T20:59:56.971299', 'created_date': '2016-06-24'}
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