Publication Information

{'id': 'https://openalex.org/W2057723776', 'doi': 'https://doi.org/10.1093/oxfordjournals.molbev.a026144', 'title': 'Molecular evolution of the COX7A gene family in primates', 'display_name': 'Molecular evolution of the COX7A gene family in primates', 'publication_year': 1999, 'publication_date': '1999-05-01', 'ids': {'openalex': 'https://openalex.org/W2057723776', 'doi': 'https://doi.org/10.1093/oxfordjournals.molbev.a026144', 'mag': '2057723776', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10335655'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/oxfordjournals.molbev.a026144', 'pdf_url': 'https://academic.oup.com/mbe/article-pdf/16/5/619/9592229/mbe0619.pdf', 'source': {'id': 'https://openalex.org/S57552105', 'display_name': 'Molecular Biology and Evolution', 'issn_l': '0737-4038', 'issn': ['0737-4038', '1537-1719'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/mbe/article-pdf/16/5/619/9592229/mbe0619.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5113581368', 'display_name': 'Timothy R. Schmidt', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'T. R. Schmidt', 'raw_affiliation_strings': ['Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, 48201, USA'], 'affiliations': [{'raw_affiliation_string': 'Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, 48201, USA', 'institution_ids': ['https://openalex.org/I185443292']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112728458', 'display_name': 'M. Goodman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'M. Goodman', 'raw_affiliation_strings': ['Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, 48201, USA'], 'affiliations': [{'raw_affiliation_string': 'Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, 48201, USA', 'institution_ids': ['https://openalex.org/I185443292']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5026416444', 'display_name': 'Lawrence I. Grossman', 'orcid': 'https://orcid.org/0000-0002-1059-9358'}, 'institutions': [{'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'L. I. Grossman', 'raw_affiliation_strings': ['Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, 48201, USA'], 'affiliations': [{'raw_affiliation_string': 'Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, 48201, USA', 'institution_ids': ['https://openalex.org/I185443292']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3255, 'currency': 'USD', 'value_usd': 3255, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.485, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 45, 'citation_normalized_percentile': {'value': 0.706713, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '16', 'issue': '5', 'first_page': '619', 'last_page': '626'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11668', 'display_name': 'interferon and immune responses', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11668', 'display_name': 'interferon and immune responses', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nonsynonymous-substitution', 'display_name': 'Nonsynonymous substitution', 'score': 0.9893229}, {'id': 'https://openalex.org/keywords/molecular-evolution', 'display_name': 'Molecular evolution', 'score': 0.67790663}, {'id': 'https://openalex.org/keywords/synonymous-substitution', 'display_name': 'Synonymous substitution', 'score': 0.59885}, {'id': 'https://openalex.org/keywords/negative-selection', 'display_name': 'Negative selection', 'score': 0.49883533}, {'id': 'https://openalex.org/keywords/concerted-evolution', 'display_name': 'Concerted evolution', 'score': 0.4371875}, {'id': 'https://openalex.org/keywords/gene-conversion', 'display_name': 'Gene conversion', 'score': 0.41497433}], 'concepts': [{'id': 'https://openalex.org/C149904235', 'wikidata': 'https://www.wikidata.org/wiki/Q7049620', 'display_name': 'Nonsynonymous substitution', 'level': 4, 'score': 0.9893229}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.91939247}, {'id': 'https://openalex.org/C7602840', 'wikidata': 'https://www.wikidata.org/wiki/Q746284', 'display_name': 'Gene duplication', 'level': 3, 'score': 0.7844637}, {'id': 'https://openalex.org/C53345823', 'wikidata': 'https://www.wikidata.org/wiki/Q5531554', 'display_name': 'Gene isoform', 'level': 3, 'score': 0.752453}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.68006223}, {'id': 'https://openalex.org/C166393388', 'wikidata': 'https://www.wikidata.org/wiki/Q856529', 'display_name': 'Molecular evolution', 'level': 4, 'score': 0.67790663}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.6489288}, {'id': 'https://openalex.org/C138025448', 'wikidata': 'https://www.wikidata.org/wiki/Q7662597', 'display_name': 'Synonymous substitution', 'level': 5, 'score': 0.59885}, {'id': 'https://openalex.org/C5911399', 'wikidata': 'https://www.wikidata.org/wiki/Q2278983', 'display_name': 'Gene family', 'level': 4, 'score': 0.5366186}, {'id': 'https://openalex.org/C7386963', 'wikidata': 'https://www.wikidata.org/wiki/Q3954859', 'display_name': 'Negative selection', 'level': 4, 'score': 0.49883533}, {'id': 'https://openalex.org/C141036', 'wikidata': 'https://www.wikidata.org/wiki/Q5158537', 'display_name': 'Concerted evolution', 'level': 4, 'score': 0.4371875}, {'id': 'https://openalex.org/C112212490', 'wikidata': 'https://www.wikidata.org/wiki/Q471134', 'display_name': 'Gene conversion', 'level': 4, 'score': 0.41497433}, {'id': 'https://openalex.org/C90132467', 'wikidata': 'https://www.wikidata.org/wiki/Q171184', 'display_name': 'Phylogenetics', 'level': 3, 'score': 0.36387157}, {'id': 'https://openalex.org/C78458016', 'wikidata': 'https://www.wikidata.org/wiki/Q840400', 'display_name': 'Evolutionary biology', 'level': 1, 'score': 0.3548932}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.32945746}, {'id': 'https://openalex.org/C141231307', 'wikidata': 'https://www.wikidata.org/wiki/Q7020', 'display_name': 'Genome', 'level': 3, 'score': 0.14343369}, {'id': 'https://openalex.org/C87253356', 'wikidata': 'https://www.wikidata.org/wiki/Q1106472', 'display_name': 'Codon usage bias', 'level': 4, 'score': 0.0672259}], 'mesh': [{'descriptor_ui': 'D003576', 'descriptor_name': 'Electron Transport Complex IV', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D019143', 'descriptor_name': 'Evolution, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005810', 'descriptor_name': 'Multigene Family', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D011323', 'descriptor_name': 'Primates', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003576', 'descriptor_name': 'Electron Transport Complex IV', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014644', 'descriptor_name': 'Genetic Variation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007527', 'descriptor_name': 'Isoenzymes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D007527', 'descriptor_name': 'Isoenzymes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005810', 'descriptor_name': 'Multigene Family', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D009928', 'descriptor_name': 'Organ Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011323', 'descriptor_name': 'Primates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017386', 'descriptor_name': 'Sequence Homology, Amino Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/oxfordjournals.molbev.a026144', 'pdf_url': 'https://academic.oup.com/mbe/article-pdf/16/5/619/9592229/mbe0619.pdf', 'source': {'id': 'https://openalex.org/S57552105', 'display_name': 'Molecular Biology and Evolution', 'issn_l': '0737-4038', 'issn': ['0737-4038', '1537-1719'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10335655', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/oxfordjournals.molbev.a026144', 'pdf_url': 'https://academic.oup.com/mbe/article-pdf/16/5/619/9592229/mbe0619.pdf', 'source': {'id': 'https://openalex.org/S57552105', 'display_name': 'Molecular Biology and Evolution', 'issn_l': '0737-4038', 'issn': ['0737-4038', '1537-1719'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 48, 'referenced_works': ['https://openalex.org/W13565163', 'https://openalex.org/W1487728646', 'https://openalex.org/W1525734744', 'https://openalex.org/W1547701561', 'https://openalex.org/W1581619899', 'https://openalex.org/W1786546753', 'https://openalex.org/W1911863642', 'https://openalex.org/W1955858074', 'https://openalex.org/W1967536299', 'https://openalex.org/W1967743863', 'https://openalex.org/W1967888351', 'https://openalex.org/W1968746186', 'https://openalex.org/W1972929994', 'https://openalex.org/W1974572661', 'https://openalex.org/W1984421378', 'https://openalex.org/W1991653444', 'https://openalex.org/W1991948656', 'https://openalex.org/W1997672380', 'https://openalex.org/W2010279801', 'https://openalex.org/W2018861292', 'https://openalex.org/W2024164720', 'https://openalex.org/W2026174588', 'https://openalex.org/W2027574957', 'https://openalex.org/W2028673291', 'https://openalex.org/W2029130887', 'https://openalex.org/W2029353325', 'https://openalex.org/W2042789248', 'https://openalex.org/W2049058233', 'https://openalex.org/W2051585502', 'https://openalex.org/W2059834781', 'https://openalex.org/W2059933406', 'https://openalex.org/W2069297519', 'https://openalex.org/W2069420439', 'https://openalex.org/W2080429646', 'https://openalex.org/W2094576801', 'https://openalex.org/W2094672597', 'https://openalex.org/W2106258670', 'https://openalex.org/W2106305197', 'https://openalex.org/W2107603775', 'https://openalex.org/W2113253344', 'https://openalex.org/W2114471659', 'https://openalex.org/W2117281006', 'https://openalex.org/W2138270253', 'https://openalex.org/W2150264392', 'https://openalex.org/W215319721', 'https://openalex.org/W4236717642', 'https://openalex.org/W4252664819', 'https://openalex.org/W44824404'], 'related_works': ['https://openalex.org/W2513840829', 'https://openalex.org/W2151951677', 'https://openalex.org/W2113286403', 'https://openalex.org/W2063275805', 'https://openalex.org/W1994163109', 'https://openalex.org/W1993752507', 'https://openalex.org/W1973812096', 'https://openalex.org/W1902721338', 'https://openalex.org/W187533858', 'https://openalex.org/W1772402814'], 'abstract_inverted_index': {'COX': [0, 10, 69], 'VIIa': [1], 'is': [2, 93, 108, 164], 'one': [3, 13], 'of': [4, 8, 14, 25, 33, 39, 75, 81, 109, 121, 146, 150, 169], '10': [5], 'nuclear-encoded': [6], 'subunits': [7], 'the': [9, 43, 68, 82, 113, 137, 147, 167], 'holoenzyme,': [11], 'and': [12], 'three': [15], 'that': [16, 38, 67, 106, 126], 'have': [17, 54, 155], 'isoforms': [18, 115], 'with': [19, 166], 'tissue-specific': [20, 170], 'differences': [21], 'in': [22, 48, 62, 102, 136, 159], 'expression.': [23], 'Analysis': [24], 'nucleotide': [26, 122], 'substitution': [27, 99, 123, 134], 'rates': [28, 124], 'revealed': [29], 'an': [30, 73, 131], 'accelerated': [31, 132], 'rate': [32, 135], 'nonsynonymous': [34, 97, 133], 'substitutions': [35, 41], 'relative': [36], 'to': [37], 'synonymous': [40], 'for': [42, 57], 'heart': [44], 'isoform': [45, 152], 'gene': [46, 83, 140], '(COX7AH)': [47], 'six': [49], 'primate': [50], 'lineages.': [51], 'Rate': [52], 'accelerations': [53], 'been': [55, 88, 156], 'noted': [56], 'four': [58], 'other': [59], 'COX-related': [60], 'genes': [61], 'this': [63], 'time': [64], 'period,': [65], 'suggesting': [66], 'holoenzyme': [70], 'has': [71, 86], 'experienced': [72, 130], 'episode': [74], 'adaptive': [76], 'evolution.': [77, 161], 'A': [78], 'third': [79], 'member': [80], 'family,': [84], 'COX7AR,': [85], 'recently': [87], 'described.': [89], 'Although': [90], 'its': [91], 'function': [92], 'currently': [94], 'unknown,': [95], 'low': [96], 'substitution/synonymous': [98], '(N/S)': [100], 'ratios': [101], 'mammalian': [103, 160], 'evolution': [104, 168], 'suggest': [105], 'COX7AR': [107], 'functional': [110], 'importance.': [111], 'When': [112], 'COX7A': [114], 'were': [116], 'divided': [117], 'into': [118], 'domains,': [119], 'examination': [120], 'suggested': [125], 'mitochondrial': [127], 'targeting': [128, 148], 'residues': [129, 149], 'period': [138], 'following': [139], 'duplication.': [141], 'In': [142], 'contrast,': [143], 'paralogous': [144], 'comparisons': [145], 'each': [151], 'show': [153], 'they': [154], 'relatively': [157], 'conserved': [158], 'This': [162], 'pattern': [163], 'consistent': [165], 'function.': [171]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2057723776', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2025-01-02T09:57:35.852222', 'created_date': '2016-06-24'}