Sialylated Core 1 O-Glycans Influence the Sorting of Pmel17/gp100 and Determine Its Capacity to Form Fibrils

Name: Work Video:
Duration: 3 min 30 s
Julio C. Valencia; François Rouzaud; Sylvain Julien; Kevin G. Chen; Thierry Passeron; Yuji Yamaguchi; Mones Abu‐Asab; Maria Tsokos; Gertrude E. Costin; Hiroshi Yamaguchi; Lisa M. Jenkins; Kunio Nagashima; Ettore Appella; Vincent J. Hearing
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'https://openalex.org/W2117398821', 'https://openalex.org/W2125687860', 'https://openalex.org/W2129850004', 'https://openalex.org/W2135736561', 'https://openalex.org/W2141003137', 'https://openalex.org/W2147898185', 'https://openalex.org/W2148640160', 'https://openalex.org/W2160378954', 'https://openalex.org/W2160447553', 'https://openalex.org/W2161622051', 'https://openalex.org/W2163796053', 'https://openalex.org/W2168325755', 'https://openalex.org/W2170235747', 'https://openalex.org/W2171265254', 'https://openalex.org/W2171346238'], 'related_works': ['https://openalex.org/W4391748392', 'https://openalex.org/W4244138459', 'https://openalex.org/W3083355397', 'https://openalex.org/W2258980318', 'https://openalex.org/W2195440971', 'https://openalex.org/W2160600646', 'https://openalex.org/W2159558852', 'https://openalex.org/W2151998416', 'https://openalex.org/W2028136243', 'https://openalex.org/W2014029442'], 'abstract_inverted_index': {'Pmel17': [0, 29, 44, 81, 169, 177, 207, 232, 261, 276, 313, 401, 409, 439, 487, 592, 626, 1008, 1360, 1412, 1422, 1485, 1581, 1654, 1783, 1811, 2094, 2291, 2783, 2969, 3823, 4276, 4337], 'is': [1, 6, 32, 48, 83, 152, 161, 233, 238, 264, 280, 315, 384, 393, 593, 608, 627, 663, 680, 995, 1043, 1146, 1413, 1424, 1437, 1526, 1576, 1586, 1757, 1806, 2810, 3542, 4225], 'a': [2, 39, 67, 226, 234, 271, 299, 458, 496, 630, 677, 684, 737, 1274, 1362, 1419, 1431, 1506, 1511, 1517, 1587, 1695, 1700, 2041, 2133, 2213, 2232, 2408, 2421, 2455, 2732, 2788, 2881, 2960, 2976, 3435, 3534, 4211, 4243, 4340], 'melanocyte/melanoma-specific': [3, 235], 'protein': [4, 236, 1508, 2351, 3829, 4019, 4053, 4234], 'that': [5, 23, 82, 109, 121, 150, 159, 176, 196, 237, 255, 314, 341, 353, 382, 391, 408, 428, 475, 607, 614, 741, 1371, 1418, 1484, 1491, 1500, 1563, 1726, 1756, 1767, 1782, 2868, 3438, 3533], 'essential': [7, 239, 609, 1044], 'for': [8, 240, 1045, 1160, 1407, 1763, 2199, 2538, 2566, 2798, 2857, 3086, 3116, 3157, 3219, 3329, 3637, 3778, 3837, 3855, 3931, 3941, 3959, 4027, 4042, 4058, 4079, 4115], 'the': [9, 24, 35, 55, 58, 77, 97, 137, 156, 164, 179, 188, 202, 241, 256, 267, 287, 290, 309, 329, 369, 388, 396, 411, 420, 434, 501, 506, 596, 611, 617, 636, 752, 868, 872, 877, 956, 1004, 1040, 1046, 1074, 1076, 1102, 1134, 1138, 1149, 1161, 1168, 1181, 1197, 1331, 1347, 1408, 1427, 1522, 1577, 1656, 1671, 1678, 1704, 1722, 1764, 1791, 1798, 1804, 1814, 2023, 2089, 2205, 2339, 2347, 2362, 2372, 2413, 2437, 2449, 2501, 2654, 2661, 2683, 2696, 2722, 2780, 2824, 2858, 2870, 2935, 3007, 3017, 3167, 3175, 3252, 3349, 3358, 3425, 3440, 3526, 3545, 3548, 3551, 3581, 3584, 3588, 3607, 3745, 3768, 3828, 3960, 3964, 4088, 4097, 4101, 4157, 4222, 4272, 4331, 4373, 4391, 4397], 'maturation': [10, 242, 612], 'of': [11, 28, 63, 80, 96, 101, 139, 168, 182, 198, 206, 243, 260, 295, 312, 328, 333, 371, 400, 414, 430, 438, 505, 598, 613, 622, 1003, 1007, 1054, 1140, 1151, 1163, 1173, 1183, 1201, 1267, 1333, 1349, 1355, 1364, 1411, 1421, 1519, 1543, 1573, 1580, 1589, 1653, 1658, 1677, 1681, 1690, 1707, 1800, 1810, 1988, 2046, 2092, 2242, 2273, 2446, 2658, 2660, 2682, 2779, 2893, 2967, 3225, 3251, 3258, 3279, 3282, 3290, 3320, 3368, 3583, 3590, 3853, 3947, 4196, 4229, 4245, 4275, 4336, 4377], 'melanosomes': [12, 244, 606, 1441], 'to': [13, 51, 85, 131, 190, 245, 283, 317, 363, 422, 492, 595, 610, 668, 683, 695, 908, 1088, 1440, 1666, 1687, 1720, 1742, 1747, 1793, 2346, 2371, 2385, 2470, 2487, 2645, 2853, 3016, 3106, 3174, 3357, 3531, 3592, 3744, 3754, 3767, 4156, 4328], 'form': [14, 27, 191, 246, 259, 423, 672, 687, 1579, 1794, 2866], 'mature,': [15, 247], 'fibrillar,': [16, 248], 'and': [17, 61, 93, 99, 113, 158, 185, 204, 208, 215, 220, 223, 249, 293, 325, 331, 345, 390, 417, 436, 440, 447, 452, 455, 488, 616, 620, 665, 867, 871, 994, 1010, 1042, 1052, 1086, 1091, 1136, 1170, 1176, 1199, 1206, 1367, 1375, 1490, 1591, 1655, 1675, 1716, 1751, 1788, 1796, 1822, 1830, 1941, 1977, 2018, 2037, 2085, 2296, 2300, 2319, 2336, 2356, 2382, 2485, 2517, 2533, 2568, 2663, 2680, 2693, 2712, 2727, 2777, 2782, 2803, 2823, 2838, 2863, 2942, 2945, 2975, 2986, 2993, 3010, 3021, 3084, 3104, 3122, 3255, 3298, 3434, 3452, 3460, 3467, 3471, 3475, 3509, 3595, 3602, 3700, 3763, 3864, 3872, 3937, 3954, 3971, 4018, 4035, 4047, 4070, 4085, 4094, 4121, 4138, 4200, 4338, 4375, 4385], 'pigmented': [18, 250, 1584], 'organelles.': [19, 251], 'Recently,': [20, 252, 1415], 'we': [21, 65, 194, 253, 297, 426, 1416, 1693, 1780, 2730, 4066, 4379], 'reported': [22, 254, 1340, 1417, 2147, 3372, 4241, 4342], 'less': [25, 257], 'glycosylated': [26, 153, 258, 385, 667, 1488], '(termed': [30, 45, 71, 262, 277, 303, 673, 688], 'iPmel17)': [31, 263], 'sorted': [33, 49, 162, 265, 281, 394, 1425, 1438], 'via': [34, 266, 1426], 'plasma': [36, 268, 1428], 'membrane': [37, 269, 473, 502, 1429], 'in': [38, 87, 128, 136, 155, 171, 212, 270, 319, 360, 368, 387, 403, 444, 500, 693, 1039, 1073, 1167, 1186, 1196, 1203, 1346, 1352, 1430, 1521, 1583, 1659, 1670, 1703, 1785, 1998, 2026, 2032, 2144, 2482, 2492, 2508, 2526, 2605, 2695, 2721, 3147, 3222, 3287, 3294, 3336, 3847, 3919, 3928, 3956, 3963, 3973, 4106, 4141, 4193, 4236, 4248, 4271], 'manner': [40, 272, 1432], 'distinct': [41, 59, 273, 291, 1433, 1496], 'from': [42, 124, 274, 356, 478, 635, 1434, 1770, 1972, 1981, 2014, 2022, 2259, 2324, 2458, 2715, 2790, 2880, 3346, 3587, 3611, 3827, 4215, 4382], 'mature': [43, 275], 'mPmel17),': [46, 278, 689], 'which': [47, 279, 1145, 1179, 1436, 1575], 'directly': [50, 282, 1439], 'melanosomes.': [52, 284], 'To': [53, 285, 1556, 1683, 4371], 'clarify': [54, 286], 'mechanism(s)': [56, 288], 'underlying': [57, 289], 'processing': [60, 98, 170, 292, 330, 402, 1652, 1724, 1750], 'sorting': [62, 100, 205, 294, 332, 437, 1348, 1752, 1812], 'Pmel17,': [64, 296], 'generated': [66, 298, 4214], 'highly': [68, 300, 1275, 1696], 'specific': [69, 301, 1697, 3442], 'antibody': [70, 108, 302, 340, 1698, 2129, 2275, 4262], 'αPEP25h)': [72, 304], 'against': [73, 305, 1699, 2132, 2290, 2500, 4266, 4390], 'an': [74, 107, 306, 339, 599, 669, 1807, 2396, 2671], 'epitope': [75, 307], 'within': [76, 308, 603, 624, 1101], 'repeat': [78, 310, 782, 838], 'domain': [79, 311, 508], 'sensitive': [84, 316], 'changes': [86, 318], 'O-glycosylation.': [88, 320], 'αPEP25h': [89, 119, 321, 351, 1733, 2127, 4041, 4078, 4258, 4263, 4324], 'recognizes': [90, 110, 322, 342, 1714, 2088, 4396], 'only': [91, 127, 323, 359, 676, 4330], 'iPmel17': [92, 102, 112, 122, 151, 324, 334, 344, 354, 383, 957, 1715, 1749, 1768], 'allows': [94, 326], 'analysis': [95, 327, 2387, 3427, 3519, 4146], 'when': [103, 335, 3547], 'compared': [104, 336, 1753, 4386], 'with': [105, 144, 337, 376, 1194, 1210, 1273, 1732, 1754, 2002, 2209, 2236, 2268, 2338, 2359, 2407, 2454, 2535, 2548, 2558, 2984, 3076, 3082, 3114, 3126, 3135, 3248, 3325, 3606, 3739, 3758, 3773, 3832, 3850, 3944, 4014, 4037, 4052, 4074, 4091, 4096, 4111, 4134], 'αPEP13h,': [106, 338], 'both': [111, 343], 'mPmel17.': [114, 346], 'Our': [115, 347], 'novel': [116, 348], 'findings': [117, 349], 'using': [118, 350, 2212, 2264, 2282, 2361, 2436, 2506, 2670, 2699, 2959, 3006, 3166, 3348, 3365, 3424, 4147, 4210], 'demonstrate': [120, 352, 1762], 'differs': [123, 355, 1769], 'mPmel17': [125, 357, 731, 1755, 1771], 'not': [126, 358, 4339], 'its': [129, 361, 1344, 1373, 1743, 2864, 4387], 'sensitivity': [130, 362, 4374], 'endoglycosidase': [132, 364, 768, 824, 961], 'H,': [133, 365], 'but': [134, 366, 675, 1095], 'also': [135, 367], 'content': [138, 370, 1410, 4163, 4224], 'core': [140, 372, 1036, 1079, 1705, 1776, 4273], '1': [141, 373, 1777, 2038, 2042, 3117, 3158, 3256, 3280, 3288, 4197], 'O-glycans': [142, 374], 'modified': [143, 375], 'sialic': [145, 183, 199, 377, 415, 431, 1152, 1164, 1184, 1334, 1786, 1801], 'acid.': [146, 378, 1165], 'This': [147, 379], 'evidence': [148, 380], 'reveals': [149, 175, 381, 407], 'differently': [154, 386, 1489], 'Golgi': [157, 389, 1103], 'it': [160, 392, 4381], 'through': [163, 395, 1813], 'secretory': [165, 397, 1815], 'pathway.': [166, 398, 1816], 'Analysis': [167, 399, 2679], 'glycosylation-deficient': [172, 404], 'mutant': [173, 405, 1943], 'cells': [174, 406, 1829, 1832, 1936, 1945, 2523, 2995, 3347, 3916, 3968], 'lacking': [178, 410], 'correct': [180, 412], 'addition': [181, 197, 413, 429, 1150, 1162, 1182, 1799, 3278], 'acid': [184, 200, 416, 432, 498, 1153, 1185, 1335, 1787, 1802, 3293, 3616], 'galactose': [186, 418, 1789], 'loses': [187, 419, 1790], 'ability': [189, 421, 1792], 'fibrils.': [192, 424], 'Furthermore,': [193, 425, 1779], 'show': [195, 427, 1781], 'affects': [201, 433], 'stability': [203, 435], 'reduces': [209, 441], 'pigmentation.': [210, 442], 'Alterations': [211, 443], 'sialyltransferase': [213, 445, 1341], 'activity': [214, 446, 1172, 1342, 3213], 'substrates': [216, 448], 'differ': [217, 449, 490], 'between': [218, 450], 'normal': [219, 451, 774, 830, 4015, 4135], 'transformed': [221, 453], 'melanocytes': [222, 454], 'may': [224, 456, 1096, 1494], 'represent': [225, 457], 'critical': [227, 459, 594], 'change': [228, 460], 'during': [229, 461], 'malignant': [230, 462, 1211, 1827], 'transformation.': [231, 463], 'The': [464, 1498, 1570, 1650, 1990, 2126, 2240, 2271, 2807, 2875, 2929, 2955, 3273, 3306, 3318, 3449, 3540, 3574], 'human': [465, 775, 831, 1826, 1991, 2015, 2093, 2502], 'PMEL17': [466], 'gene': [467], 'encodes': [468], 'two': [469, 483, 743, 2716, 4256, 4332], 'type': [470, 1142, 1514], 'I': [471, 1085, 1175, 3447], 'integral': [472], 'proteins': [474, 1351], 'are': [476, 1081, 1158, 1192, 2311, 2719, 2827, 4239], 'translated': [477], 'alternatively': [479], 'spliced': [480], 'mRNAs.': [481], 'Those': [482, 903], 'proteins,': [484], 'known': [485, 1527], 'as': [486, 491, 629, 633, 1528, 1835, 1937, 1939, 1948, 2005, 2049, 2146, 2307, 2312, 2609, 2895, 3032, 3182, 3270, 3371, 3489, 3544, 3783, 3876, 4166, 4227, 4242], 'gp100,': [489], 'whether': [493, 2646], 'they': [494, 2647], 'include': [495, 2288], '7-amino': [497], 'motif': [499], 'proximal': [503], 'region': [504, 879, 1706, 4274], 'luminal': [507], '(1Kwon': [509], 'B.S.': [510, 2160, 4280, 4292], 'Chintamaneni': [511], 'C.D.': [512], 'Kozak': [513], 'C.A.': [514], 'Copeland': [515], 'N.G.': [516], 'Gilbert': [517], 'D.J.': [518], 'Jenkins': [519], 'N.A.': [520], 'Barton': [521], 'D.E.': [522], 'Francke': [523], 'U.': [524, 533, 1858, 2115], 'Kobayashi': [525, 709, 972, 2054, 4171], 'Y.': [526, 1457, 2063, 2613, 3389, 3619, 3712, 3992], 'Kim': [527], 'K.K.': [528, 4278], 'Proc.': [529, 1854, 2111], 'Natl.': [530, 1855, 2112], 'Acad.': [531, 1856, 2113], 'Sci.': [532, 1126, 1472, 1857, 2114, 3404], 'S.': [534, 1105, 1859, 2059, 2116, 3188, 3984], 'A.': [535, 1113, 1242, 1291, 1447, 1860, 1954, 2117, 2581, 2619, 3195, 3379, 3621], '1991;': [536], '88:': [537], '9228-9232Crossref': [538], 'PubMed': [539, 564, 587, 659, 726, 898, 932, 950, 989, 1030, 1066, 1130, 1232, 1257, 1296, 1312, 1398, 1476, 1624, 1645, 1864, 1894, 1930, 1965, 2077, 2121, 2174, 2192, 2596, 2635, 2769, 2924, 3066, 3206, 3408, 3569, 3629, 3655, 3695, 3728, 3817, 3910, 4006, 4182, 4299, 4319, 4366], 'Scopus': [540, 588, 727, 899, 933, 951, 990, 1031, 1067, 1233, 1258, 1297, 1313, 1399, 1477, 1625, 1646, 1865, 1895, 1931, 1966, 2078, 2122, 2193, 2597, 2636, 2770, 2925, 3067, 3207, 3409, 3570, 3630, 3656, 3696, 3729, 3818, 3911, 4007, 4183, 4300, 4320, 4367], '(133)': [541], 'Google': [542, 565, 590, 660, 729, 901, 935, 953, 992, 1033, 1069, 1131, 1235, 1260, 1299, 1315, 1328, 1401, 1479, 1627, 1648, 1867, 1897, 1933, 1968, 2080, 2124, 2175, 2195, 2599, 2638, 2772, 2927, 3069, 3209, 3411, 3572, 3632, 3658, 3698, 3731, 3820, 3913, 4009, 4185, 4302, 4322, 4369], 'Scholar,': [543, 566, 936, 1236, 1300, 1316, 1628, 1868, 1898, 2176, 4303], '2Adema': [544], 'G.J.': [545, 640], 'de': [546, 641], 'Boer': [547, 642], 'A.J.': [548, 643, 3996], 'Vogel': [549, 644], 'A.M.': [550, 645], 'Loenen': [551, 646], 'W.A.M.': [552, 647], 'Figdor': [553, 648], 'C.G.': [554, 649], 'J.': [555, 650, 715, 892, 926, 978, 1024, 1107, 1124, 1221, 1238, 1252, 1463, 1470, 1535, 1541, 1845, 1849, 1872, 1883, 1910, 1919, 2073, 2102, 2106, 2165, 2188, 2579, 2587, 2590, 2631, 2749, 2758, 3046, 3055, 3201, 3395, 3402, 3565, 3625, 3644, 3675, 3684, 3710, 3717, 3797, 3806, 3890, 3899, 4002, 4174, 4310, 4355], 'Biol.': [556, 651, 716, 894, 928, 941, 979, 1026, 1222, 1884, 1920, 2166, 2759, 3056, 3645, 3685, 3718, 3807, 3900], 'Chem.': [557, 652, 717, 980, 1223, 1885, 1921, 2167, 2760, 3057, 3646, 3686, 3719, 3808, 3901], '1994;': [558, 584, 653, 1395, 2168], '269:': [559, 654, 2169], '20126-20133Abstract': [560, 655], 'Full': [561, 656, 721, 723, 945, 947, 984, 986, 1227, 1229, 1619, 1621, 1889, 1891, 1925, 1927, 2171, 2764, 2766, 3061, 3063, 3650, 3652, 3690, 3692, 3723, 3725, 3812, 3814, 3905, 3907, 4316, 4361, 4363], 'Text': [562, 657, 722, 724, 946, 948, 985, 987, 1228, 1230, 1620, 1622, 1890, 1892, 1926, 1928, 2172, 2765, 2767, 3062, 3064, 3651, 3653, 3691, 3693, 3724, 3726, 3813, 3815, 3906, 3908, 4317, 4362, 4364], 'PDF': [563, 658, 725, 949, 988, 1231, 1623, 1893, 1929, 2173, 2768, 3065, 3654, 3694, 3727, 3816, 3909, 4318, 4365], '3Maresh': [567], 'G.A.': [568, 1379], 'Wang': [569, 1380], 'W.-C.': [570, 1381], 'Beam': [571, 1382], 'K.S.': [572, 1383, 2065], 'Malacko': [573, 1384], 'A.R.': [574, 1385], 'Hellstrom': [575, 577, 1386, 1388], 'I.': [576, 1387, 1603, 1958], 'K.E.': [578, 1389], 'Marquardt': [579, 1390], 'H.': [580, 704, 967, 1121, 1248, 1391, 1445, 1537, 1900, 1908, 2739, 2747, 3036, 3044, 3377, 3665, 3673, 3708, 3787, 3795, 3880, 3888], 'Arch.': [581, 1392], 'Biochem.': [582, 1305, 1393, 3202, 4001, 4178], 'Biophys.': [583, 1306, 1394], '311:': [585, 1396], '95-102Crossref': [586, 1397], '(37)': [589, 1400], 'Scholar).': [591, 661, 730, 902, 954, 1034, 1070, 1132, 1261, 1329, 1402, 1480, 1555, 1649, 1934, 1969, 2081, 2125, 2196, 2600, 2639, 2773, 2928, 3070, 3210, 3412, 3573, 3732, 3821, 3914, 4010, 4186, 4323, 4370], 'formation': [597, 1139], 'internal': [600], 'fibrillar': [601], 'matrix': [602], 'stage': [604], 'II': [605, 1087], 'organelle': [615, 2309], 'subsequent': [618], 'synthesis': [619], 'deposition': [621], 'melanin': [623, 4201, 4217, 4223, 4230], 'it.': [625], 'synthesized': [628, 1509, 2203, 2802], '68.6-kDa': [631], 'protein,': [632], 'deduced': [634], 'cloned': [637], 'cDNA': [638, 2861], '(2Adema': [639], 'It': [662], 'rapidly': [664], 'quantitatively': [666], '"immature"': [670], '∼95-kDa': [671], 'iPmel17),': [674], 'limited': [678], 'amount': [679], 'further': [681, 3865], 'processed': [682, 2608, 4140], '"mature"': [685], '∼115-kDa': [686], 'due': [690], 'at': [691, 697, 1098, 1593, 1739, 1803, 2379, 2541, 2552, 3089, 3119, 3130, 3160, 3216, 3327, 3482, 3494, 3500, 3506, 3512, 3840, 3858, 3934, 4030, 4045, 4061, 4082, 4118, 4207, 4254], 'least': [692, 3328, 4255], 'part': [694], 'N-glycosylation': [696, 1090], 'five': [698], 'possible': [699], 'sites': [700, 1100], '(4Yasumoto': [701, 964], 'K.': [702, 965, 1455, 1461, 1878, 1880, 1904, 2061, 2152, 2156, 2178, 2182, 2575, 2583, 2615, 2743, 3040, 3387, 3393, 3623, 3669, 3791, 3884, 3982], 'Watabe': [703, 966, 1444, 3376, 3707], 'Valencia': [705, 968, 1842, 1901, 2099, 2740, 2908, 3037, 3558, 3666, 3788, 3881, 3979], 'J.C.': [706, 969, 1111, 1443, 1630, 1843, 1902, 2100, 2573, 2741, 2909, 3038, 3199, 3375, 3559, 3667, 3789, 3882, 3980], 'Kushimoto': [707, 970, 1905, 2744, 3041, 3670, 3792, 3885], 'T.': [708, 710, 971, 973, 1123, 1304, 1632, 1839, 1870, 1906, 2053, 2096, 2150, 2623, 2745, 3042, 3671, 3706, 3793, 3886, 4305], 'Appella': [711, 974, 1466, 1850, 1915, 2107, 2754, 3051, 3398, 3680, 3802, 3895], 'E.': [712, 975, 1467, 1851, 1916, 2108, 2755, 3052, 3399, 3681, 3803, 3896], 'Hearing': [713, 976, 1468, 1637, 1852, 1881, 1917, 2070, 2109, 2163, 2185, 2628, 2756, 2914, 3053, 3400, 3562, 3682, 3715, 3804, 3897, 3999, 4175], 'V.J.': [714, 977, 1469, 1638, 1853, 1882, 1918, 2071, 2110, 2164, 2186, 2589, 2629, 2757, 2915, 3054, 3401, 3563, 3683, 3716, 3805, 3898, 4000, 4176], '2004;': [718, 981, 1922, 2761, 3058, 3687, 3809, 3902], '279:': [719, 982, 1923, 2762, 3059, 3688, 3810, 3903], '28330-28338Abstract': [720, 983], '(60)': [728, 991], 'can': [732, 905, 1486, 1515, 1734], 'then': [733, 2486, 2546, 3094, 3124, 3596, 3939, 4050, 4086, 4240], 'be': [734, 1487, 1735, 4326], 'cleaved': [735, 2971], 'by': [736, 911, 1083, 1148, 1510, 1737, 1759, 1772, 2007, 2142, 2204, 2226, 2247, 2278, 2388, 2556, 2805, 2890, 2940, 2946, 2998, 3004, 3277, 3315, 3579, 3737, 3862, 3867, 4205, 4232], 'furin-like': [738], 'proprotein': [739], 'convertase': [740], 'generates': [742], 'fragments,': [744], 'one': [745], 'small': [746], 'fragment': [747, 875, 2973], '(cPmel17,': [748], '∼26': [749], 'kDa)': [750], 'containing': [751], 'transmembrane': [753, 760, 816], '(TM)': [754], '3The': [755, 811], 'abbreviations': [756, 812], 'used': [757, 813, 2198, 2287, 2306, 2731, 2852], 'are:': [758, 814], 'TM,': [759, 815], 'domain;': [761, 783, 817, 839], 'CMK,': [762, 818], 'Dec-RVKR-CMK;': [763, 819], 'DANA,': [764, 820], '2,3-dehydro-2-deoxy-N-acetylneuraminic': [765, 821, 3615], 'acid;': [766, 822], 'EndoH,': [767, 823], 'H;': [769, 825], 'ER,': [770, 826], 'endoplasmic': [771, 827], 'reticulum;': [772, 828], 'NHM,': [773, 829], 'melanocytes;': [776, 832], 'PNGaseF,': [777, 833], 'peptide': [778, 834, 1701, 2138, 2215, 2223, 2244, 2266], 'endopeptidase': [779, 835], 'F;': [780, 836], 'RPT,': [781, 837], 'ST3Gal': [784, 840, 1174, 3464], 'I,': [785, 841, 3465], 'CMP-Neu5Ac:Galα1-3GalNAc': [786, 791, 842, 847], 'α-2,3-sialyltransferase': [787, 843], 'I;': [788, 844], 'ST6GalNAc': [789, 845, 3472], 'II,': [790, 846, 1178, 3473], 'α-2,6-sialyltransferase': [792, 848], 'II;': [793, 849], 'CHO,': [794, 850, 2991], 'Chinese': [795, 851], 'hamster': [796, 852], 'ovary;': [797, 853], 'BSM,': [798, 854], 'bovine': [799, 855, 3263], 'submaxillary': [800, 856, 3264], 'mucin;': [801, 857], 'BFA,': [802, 858], 'brefeldin': [803, 859, 3662], 'A;': [804, 860], 'FL,': [805, 861], 'full': [806, 862], 'length;': [807, 863], 'CTD,': [808, 864], 'C-terminal': [809, 865, 869], 'domain.': [810, 866], 'domains,': [870], 'other': [873, 910, 1005, 1155], 'larger': [874], 'contains': [876, 1361, 2869], 'N-terminal': [878, 2871, 2972], '(5Berson': [880, 914, 1012], 'J.F.': [881, 915, 1013, 1607, 4352], 'Theos': [882, 916, 1014], 'A.C.': [883, 917, 1015, 1597], 'Harper': [884, 918, 1016, 1604, 4349], 'D.C.': [885, 919, 1017, 1605, 4350], 'Tenza': [886, 920, 1018, 1600], 'D.': [887, 921, 1019, 1250, 1601, 3643], 'Raposo': [888, 922, 1020, 1610], 'G.': [889, 923, 1021, 1216, 1302, 1539, 1611, 2158, 2901], 'Marks': [890, 924, 1022, 1612, 4353], 'M.S.': [891, 925, 1023, 1613, 4354], 'Cell': [893, 927, 940, 1025, 1125, 1471, 1640, 1817, 1960, 1970, 2919, 3403, 4294], '2003;': [895, 929, 942, 1027, 2074, 3566, 4358], '161:': [896, 930, 1028], '521-533Crossref': [897, 931, 1029], '(220)': [900, 934, 1032], 'fragments': [904, 2877, 2931], 'remain': [906], 'bound': [907], 'each': [909, 2243, 2265, 2274, 2704, 3311, 3523, 4220], 'S-S': [912], 'bonds': [913], "6Dell'Angelica": [937], 'E.C.': [938], 'Trends': [939], '13:': [943], '503-506Abstract': [944], '(34)': [952], 'However,': [955], 'formed': [958], 'remains': [959], 'fully': [960], 'H': [962], '(EndoH)-sensitive': [963], 'Scholar)': [993], 'significantly': [996], 'more': [997], 'stable': [998], 'over': [999], 'time': [1000, 1766, 3326, 3420], 'than': [1001], 'either': [1002, 4038, 4075], 'forms': [1006, 1377, 1493, 1680, 4335], '(mPmel17': [1009], 'cPmel17)': [1011], 'N-Linked': [1035], 'glycosylation': [1037, 1093, 1503, 1661, 1738], 'begins': [1038], 'ER': [1041], 'function,': [1047], 'stability,': [1048], 'folding,': [1049], 'intracellular': [1050, 2308], 'transport,': [1051], 'secretion': [1053], 'glycoproteins': [1055, 1202], '(for': [1056], 'review': [1057], 'see': [1058], 'Ref.': [1059], '7Spiro': [1060], 'R.G.': [1061], 'Glycobiology.': [1062, 1253], '2002;': [1063], '12:': [1064], 'R43-R56Crossref': [1065], '(1028)': [1068], 'Upon': [1071], 'arrival': [1072], 'cis-Golgi,': [1075], 'initial': [1077], 'mannose-rich': [1078, 1368], 'chains': [1080, 1370, 3734], 'trimmed': [1082], 'mannosidases': [1084], 'continue': [1089], 'O-linked': [1092], 'starts': [1094, 3550], 'occur': [1097], 'multiple': [1099], '(8Rottger': [1104], 'White': [1106], 'Wandall': [1108], 'H.H.': [1109, 4282], 'Olivo': [1110], 'Stark': [1112], 'Bennett': [1114], 'E.P.': [1115], 'Whitehouse': [1116, 1243], 'C.': [1117, 1244, 2577, 3190], 'Berger': [1118], 'E.G.': [1119], 'Clausen': [1120, 1247], 'Nilsson': [1122], '1998;': [1127], '111:': [1128], '45-60Crossref': [1129], 'In': [1133, 1262, 1403, 4187], 'medial-': [1135], 'trans-Golgi,': [1137], 'complex': [1141, 1672], 'glycans': [1143, 3755], 'ensues,': [1144], 'terminated': [1147], 'or': [1154, 1189, 1343, 2562, 2651, 3003, 3027, 3099, 3151, 3267, 3741, 4040, 4077, 4125], 'sugars.': [1156], 'Sialyltransferases': [1157], 'responsible': [1159], 'Changes': [1166], 'expression': [1169, 2855], 'enzyme': [1171, 3212, 3253], 'ST6Gal': [1177], 'catalyze': [1180], 'positions': [1187], 'α2,3': [1188], 'α2,6,': [1190], 'respectively,': [1191], 'associated': [1193, 1209, 1272], 'alterations': [1195], 'length': [1198], 'structure': [1200, 1525], 'several': [1204], 'tumors': [1205], 'have': [1207, 1495, 1516, 1559, 1663], 'been': [1208, 1271, 1560, 1664, 3538], 'potential': [1212], '(9Naim': [1213], 'H.Y.': [1214], 'Joberty': [1215], 'Alfalah': [1217], 'M.': [1218, 1914, 1956, 2753, 3050, 3679, 3801, 3894], 'Jacob': [1219], 'R.': [1220, 1240, 1533], '1999;': [1224, 1254, 4179], '274:': [1225], '17961-17967Abstract': [1226], '(70)': [1234], '10Burchell': [1237], 'Poulsom': [1239], 'Hanby': [1241], 'Cooper': [1245], 'L.': [1246, 1318], 'Miles': [1249], 'Taylor-Papadimitriou': [1251], '9:': [1255, 4297], '1307-1311Crossref': [1256], '(153)': [1259], 'melanoma': [1263, 1828], 'cells,': [1264, 1585, 2990], 'altered': [1265], 'sialylation': [1266], 'surface': [1268], 'glycoconjugates': [1269], 'has': [1270, 1339, 1717], 'metastatic': [1276], 'phenotype': [1277], '(11Bosmann': [1278], 'H.B.': [1279], 'Bieber': [1280], 'G.F.': [1281], 'Brown': [1282], 'A.E.': [1283], 'Case': [1284], 'K.R.': [1285], 'Gersten': [1286], 'D.M.': [1287], 'Kimmerer': [1288], 'T.W.': [1289], 'Lione': [1290], 'Nature.': [1292], '1973;': [1293], '246:': [1294], '487-489Crossref': [1295], '(131)': [1298], '12Yogeeswaran': [1301], 'Tao': [1303], 'Res.': [1307, 1324, 1641, 2920, 4295], 'Commun.': [1308], '1980;': [1309, 1962], '95:': [1310], '1452-1460Crossref': [1311], '(38)': [1314, 3631], '13Dobrossy': [1317], 'Pavelic': [1319], 'Z.P.': [1320], 'Bernacki': [1321], 'R.J.': [1322], 'Cancer': [1323], '1981;': [1325], '41:': [1326], '2262-2266PubMed': [1327], 'Despite': [1330], 'importance': [1332], 'addition,': [1336], 'no': [1337, 1405, 1561], 'study': [1338, 1748], 'role': [1345], 'melanosome-specific': [1350, 1568], 'various': [1353, 1679], 'types': [1354], 'melanocytic': [1356], 'cells.': [1357], 'N-Glycans': [1358], 'on': [1359, 1505, 2231, 2333, 2395, 3096, 3300, 3310, 3522, 4123], 'mixture': [1363, 3227], 'complex,': [1365], 'hybrid,': [1366], 'carbohydrate': [1369], 'distinguish': [1372], 'secreted': [1374], 'cytoplasmic': [1376, 3342, 3369], '(3Maresh': [1378], 'contrast,': [1404], 'information': [1406], 'O-glycan': [1409], 'available.': [1414], 'glycoform': [1420], '(iPmel17)': [1423], 'mPmel17,': [1435], '(14Valencia': [1442, 3374], 'Chi': [1446, 3378], 'Rouzaud': [1448, 1875, 2904, 3380, 3993], 'F.': [1449, 1636, 1876, 2905, 3381, 3555, 3986, 3994], 'Chen': [1450, 3382], 'K.G.': [1451, 2899, 3383], 'Vieira': [1452, 1846, 1873, 1911, 2103, 2750, 3047, 3384, 3676, 3713, 3798, 3891, 3989], 'W.D.': [1453, 1847, 1874, 1912, 2104, 2751, 3048, 3385, 3677, 3714, 3799, 3892, 3990], 'Takahashi': [1454, 2614, 3386], 'Yamaguchi': [1456, 2062, 3388, 3711, 3991], 'Berens': [1458, 2624, 3390], 'W.': [1459, 2625, 3391], 'Nagashima': [1460, 3392], 'Shabanowitz': [1462, 3394], 'Hunt': [1464, 3396], 'D.F.': [1465, 3397], '2006;': [1473, 1616, 1642, 1886, 2632, 3405], '119:': [1474, 3406], '1080-1091Crossref': [1475, 3407], '(44)': [1478, 3410], 'These': [1481, 2849], 'facts': [1482], 'suggest': [1483], 'those': [1492, 4246], 'functions.': [1497], 'phenomenon': [1499], 'any': [1501], 'given': [1502, 1507], 'site': [1504], 'particular': [1512], 'cell': [1513, 1974, 1993, 3025, 3072, 4189], 'range': [1518], 'variations': [1520], 'precise': [1523], 'glycan': [1524], 'microheterogeneity': [1529], '(15Varki': [1530], 'A.P.': [1531], 'Cummings': [1532], 'Esko': [1534], 'Freeze': [1536], 'Hart': [1538], 'Marth': [1540], 'Essentials': [1542], 'Glycobiology.1st': [1544], 'Ed.': [1545], 'Cold': [1546, 1551], 'Spring': [1547, 1552], 'Harbor': [1548], 'Laboratory': [1549], 'Press,': [1550], 'Harbor,': [1553], 'NY1999Google': [1554], 'date,': [1557], 'there': [1558], 'reports': [1562], 'address': [1564], 'this': [1565, 1594, 1728, 3321], 'issue': [1566], 'regarding': [1567], 'proteins.': [1569], 'putative': [1571], 'function(s)': [1572], 'iPmel17,': [1574], 'major': [1578, 4333], 'seen': [1582], 'matter': [1588], 'conjecture': [1590], 'controversy': [1592], 'point': [1595, 3546], '(16Theos': [1596], 'Truschel': [1598], 'S.T.': [1599], 'Hurbain': [1602], 'Berson': [1606, 4351], 'Thomas': [1608], 'P.C.': [1609], 'Dev.': [1614], 'Cell.': [1615], '10:': [1617], '343-354Abstract': [1618], '(210)': [1626], '17Valencia': [1629], 'Hoashi': [1631, 2793], 'Pawelek': [1633], 'J.M.': [1634], 'Solano': [1635, 3985], 'Pigm.': [1639, 2918, 4293], '19:': [1643], '250-252Crossref': [1644], '(11)': [1647], 'rapid': [1651], 'lack': [1657], 'depth': [1660], 'studies': [1662], 'impediments': [1665], 'elucidating': [1667], 'mechanisms': [1668], 'involved': [1669], 'processing,': [1673], 'trafficking,': [1674], 'functions': [1676], 'Pmel17.': [1682, 1708], 'develop': [1684], 'another': [1685], 'tool': [1686], 'resolve': [1688], 'some': [1689], 'these': [1691, 4068], 'issues,': [1692], 'designed': [1694, 4265], 'sequence': [1702], 'That': [1709], 'antibody,': [1710], 'termed': [1711], 'αPEP25h,': [1712, 4378], 'specifically': [1713], 'allowed': [1718], 'us': [1719, 1746], 'characterize': [1721], 'different': [1723, 1774], 'events': [1725], 'generate': [1727], 'important': [1729, 1808], 'fragment.': [1730], 'Reactivity': [1731], 'blocked': [1736, 3113], 'residues': [1740, 4267], 'adjacent': [1741], 'epitope,': [1744], 'allowing': [1745], 'recognized': [1758], 'αPEP13h.': [1760], 'We': [1761], 'first': [1765], 'having': [1773], 'sialylated': [1775], 'O-glycans.': [1778], 'deficient': [1784], 'fibrils,': [1795], 'thus': [1797], 'α2,3-position': [1805], 'determinant': [1809], 'Cultures,': [1818], 'Human': [1819, 2601], 'Tissue': [1820], 'Samples,': [1821], 'Skin': [1823], 'Biopsies—Pigmented': [1824], '(MNT-1)': [1825], 'HeLa': [1831], 'were': [1833, 1946, 1979, 2020, 2034, 2202, 2262, 2331, 2353, 2418, 2498, 2524, 2545, 2607, 2642, 2668, 2686, 2710, 2801, 2851, 2878, 2932, 2957, 3030, 3074, 3093, 3112, 3123, 3145, 3164, 3180, 3275, 3285, 3334, 3416, 3422, 3456, 3487, 3529, 3604, 3735, 3756, 3825, 3845, 3874, 3917, 3926, 3938, 3969, 4012, 4033, 4049, 4104, 4132, 4139, 4191, 4203], 'cultured': [1834, 1947, 1997, 3918], 'described': [1836, 1949, 2006, 2050, 2610, 2896, 3183, 3784, 3877, 4167], 'previously': [1837, 1950, 2051, 2148, 2611, 2733, 2897, 3034, 3184, 3373, 3785, 3878, 4168], '(18Kushimoto': [1838, 2095], 'Basrur': [1840, 2097], 'V.': [1841, 2098, 3186, 3193, 4170], 'Matsunaga': [1844, 2101, 4173], 'Muller': [1848, 1871, 1909, 2105, 2748, 3045, 3674, 3709, 3796, 3889], '2001;': [1861, 2118, 2593, 3647], '98:': [1862, 2119], '10698-10703Crossref': [1863, 2120], '(188)': [1866, 2123], '19Hoashi': [1869], 'Kikuchi': [1877], 'Tamaki': [1879], '281:': [1887], '21198-21208Abstract': [1888], '(87)': [1896], '20Watabe': [1899], 'Yasumoto': [1903, 2742, 3039, 3668, 3790, 3883], 'Ando': [1907, 2746, 3043, 3672, 3794, 3887], 'Mizoguchi': [1913, 2752, 3049, 3678, 3800, 3893], '7971-7981Abstract': [1924, 2763, 3060, 3689, 3811, 3904], '(104)': [1932, 2771, 3068, 3697, 3819, 3912], 'CHO': [1935, 1944], 'well': [1938, 4392], 'Lec2': [1940], 'Lec8': [1942, 2994], '(21Gottesman': [1951], 'M.M.': [1952, 2917], 'LeCam': [1953], 'Bukowski': [1955], 'Pastan': [1957], 'Somatic': [1959], 'Genet.': [1961], '6:': [1963], '45-61Crossref': [1964], '(59)': [1967], 'extracts': [1971, 3026, 3073], 'neuroblastoma': [1973], 'lines': [1975], '(SKNAS': [1976], 'SKNSH)': [1978], 'gifts': [1980], 'Dr.': [1982, 2791], 'Maria': [1983], 'Tsokos,': [1984], 'NCI,': [1985, 2953], 'National': [1986], 'Institutes': [1987], 'Health.': [1989], 'melanocyte': [1992], 'line': [1994], 'M253': [1995], 'was': [1996, 2130, 2224, 2245, 2276, 2377, 2383, 2452, 2787, 2996, 3214, 3313, 3323, 3344, 3363, 3520, 3577, 3781, 4153, 4164, 4252, 4264], '154': [1999], 'Medium': [2000], 'supplemented': [2001, 3081], 'growth': [2003], 'factors': [2004], 'Cascade': [2008], 'Biologics': [2009], '(Portland,': [2010], 'OR).': [2011], 'Paraffin-embedded': [2012], 'samples': [2013, 2330, 3780, 3824, 3844, 4131], 'kidney,': [2016], 'uterus,': [2017], 'lung': [2019], 'obtained': [2021, 2669, 4247], 'tissue': [2024], 'bank': [2025], 'Philadelphia.': [2027], 'Shave': [2028], 'biopsies,': [2029], '4': [2030, 2542, 2553, 3131, 3220, 4021, 4083], 'mm': [2031, 2425, 3236, 3661, 3702], 'diameter,': [2033], 'taken': [2035], 'before': [2036], 'day': [2039], 'after': [2040, 3835], 'minimum': [2043], 'erythema': [2044], 'dose': [2045], 'UV': [2047], 'radiation,': [2048], '(22Tadokoro': [2052], 'N.': [2055, 4172], 'Zmudzka': [2056, 2616], 'B.Z.': [2057, 2617], 'Ito': [2058, 3983], 'Wakamatsu': [2060, 3981], 'Korossy': [2064], 'Miller': [2066, 2620], 'S.A.': [2067, 2621], 'Beer': [2068, 2626], 'J.Z.': [2069, 2627], 'FASEB': [2072, 2630, 3564], '17:': [2075, 3567, 3627], '1177-1179Crossref': [2076], '(280)': [2079], 'Antibodies,': [2082], 'Peptide': [2083, 2375], 'Synthesis,': [2084], 'Immunoaffinity': [2086], 'Purification—αPEP13h': [2087], 'C': [2090, 4398], 'terminus': [2091], 'polyclonal': [2128, 2567], 'raised': [2131], 'keyhole': [2134], 'limpet': [2135, 2140], 'hemocyanin-conjugated': [2136], 'synthetic': [2137, 2283, 4216], '(keyhole': [2139], 'hemocyanin-CTPEATGMTPAEVSIVVLSGTT-CO2H)': [2141], 'immunization': [2143], 'rabbits': [2145, 2261], '(23Kobayashi': [2149], 'Urabe': [2151, 2181], 'Orlow': [2153], 'S.J.': [2154], 'Higashi': [2155], 'Imokawa': [2157], 'Kwon': [2159, 4291], 'Potterf': [2161], 'S.B.': [2162], '29198-29205Abstract': [2170], '24Tsukamoto': [2177], 'Jackson': [2179], 'I.J.': [2180], 'Montague': [2183], 'P.M.': [2184], 'EMBO': [2187], '1992;': [2189], '11:': [2190], '519-526Crossref': [2191], '(466)': [2194], 'Peptides': [2197], 'affinity': [2200], 'purification': [2201], 'solid': [2206], 'phase': [2207, 2461, 2473, 2490, 3553], 'method': [2208, 2735], '9-fluorenylmethoxy-carbonyl': [2210], 'chemistry': [2211], '431A': [2214], 'synthesizer': [2216], '(Applied': [2217], 'Biosystems,': [2218], 'Foster': [2219], 'City,': [2220], 'CA).': [2221, 2444, 2515], 'Each': [2222, 4250], 'purified': [2225, 2804], 'high': [2227], 'pressure': [2228], 'liquid': [2229, 2390, 3316], 'chromatography': [2230], 'Vydac': [2233], 'C-4': [2234], 'column': [2235, 2431], '0.05%': [2237], 'trifluoroacetic': [2238], 'acid/water/acetonitrile.': [2239], 'mass': [2241, 2253, 2393, 2400, 2450, 2496], 'confirmed': [2246, 2277, 2939], 'matrix-assisted': [2248], 'laser': [2249, 2691], 'desorption': [2250], 'ionization': [2251], 'time-of-flight': [2252], 'spectrometry': [2254, 2394], '(Micromass,': [2255], 'Beverly,': [2256], 'MA).': [2257, 3752], 'Sera': [2258], 'immunized': [2260], 'affinity-purified': [2263, 4380], 'coupled': [2267, 2384], 'SulfoLink': [2269], '(Pierce).': [2270], 'specificity': [2272, 4376], 'enzyme-linked': [2279], 'immunosorbent': [2280], 'assay': [2281], 'peptides.': [2284], 'Monoclonal': [2285], 'antibodies': [2286, 2305, 2550, 3128, 3154, 3163], 'HMB-45': [2289], '(DAKO,': [2292], 'Carpinteria,': [2293], 'CA),': [2294], 'HMB-50': [2295], 'MART1': [2297, 2781, 2785], '(Neomarkers,': [2298], 'UK),': [2299], 'anti-V5': [2301], '(Invitrogen).': [2302, 3110, 4129], 'Other': [2303], 'monoclonal': [2304, 2569], 'markers': [2310], 'follows:': [2313, 3490], 'BIP': [2314], '(ER),': [2315], 'Vti1b': [2316], '(Golgi),': [2317], 'clathrin,': [2318], 'adaptin': [2320], 'α': [2321], '(AP2)': [2322], 'all': [2323, 2981], 'BD': [2325], 'Transduction': [2326], 'Laboratories.': [2327], 'Mass': [2328], 'Spectrometry—Immunoprecipitated': [2329], 'separated': [2332, 3095, 3861, 4051, 4122], 'Tris-glycine': [2334, 3101, 4127], 'gels': [2335, 3102, 4128], 'stained': [2337], 'colloidal': [2340], 'blue': [2341], 'staining': [2342, 2705], 'kit': [2343, 2366, 3352], '(Invitrogen)': [2344, 2938, 3002, 3080, 3103, 4110], 'according': [2345, 2370, 2644, 3015, 3173, 3356, 3743, 3766, 4155], "manufacturer's": [2348, 2373, 3018, 3746, 3769, 4158], 'instructions.': [2349, 3019, 3177, 3360, 3770, 4159], 'Retrieved': [2350], 'bands': [2352], 'reduced,': [2354], 'carbam-idomethylated,': [2355], 'in-gel': [2357], 'digested': [2358, 3846], 'trypsin': [2360], 'Montage': [2363], 'In-Gel': [2364], 'DigestZP': [2365], '(Millipore,': [2367], 'Billerica,': [2368], 'MA)': [2369, 2435, 3433], 'directions.': [2374], 'separation': [2376], 'performed': [2378, 2453, 3181, 3335, 3364, 3423, 3488, 3521, 3782, 3875, 4154], '300': [2380], 'nl/min': [2381], 'on-line': [2386], 'nanoflow': [2389], 'chromatography-electrospray': [2391], 'ionization-tandem': [2392], 'LTQ': [2397], 'ion': [2398, 2410], 'trap': [2399], 'spectrometer': [2401, 2451], '(ThermoElectron,': [2402, 2512], 'San': [2403, 2513], 'Jose,': [2404, 2514], 'CA)': [2405, 3355], 'equipped': [2406], 'nanospray': [2409], 'source.': [2411], 'From': [2412], 'eluted': [2414, 3826], 'peptides,': [2415], '2': [2416, 3295, 4028, 4043, 4059, 4080], 'μl': [2417, 3224, 3250, 4195], 'loaded': [2419], 'onto': [2420], '0.075': [2422], '×': [2423], '50': [2424, 3223, 3241, 3634, 3660], 'PicoFrit': [2426], 'BioBasic': [2427], 'C18': [2428], 'packed': [2429], 'tip': [2430], '(New': [2432, 3748, 3775], 'Objective,': [2433], 'Woburn,': [2434], 'Paradigm': [2438], 'MS4': [2439], 'MDLC': [2440], '(Michrom': [2441], 'Bioresources,': [2442], 'Auburn,': [2443], 'Elution': [2445], 'peptides': [2447], 'into': [2448, 2934, 2988], 'linear': [2456, 3324], 'gradient': [2457], '95%': [2459, 2488], 'mobile': [2460, 2472, 2489], 'A': [2462, 3515, 3663], '(5%': [2463, 2475], 'acetonitrile,': [2464], '0.5%': [2465, 2477], 'acetic': [2466, 2478], 'acid,': [2467, 2479], '94.95%': [2468, 2480], 'water)': [2469], '65%': [2471], 'B': [2474, 2491], 'water,': [2476], 'acetonitrile)': [2481], '45': [2483], 'min': [2484, 2540, 3088, 3481, 3839, 3933, 3943, 4117], '5': [2493, 3087, 3480, 3838, 4116], 'min.': [2494], 'Tandem': [2495], 'spectra': [2497], 'searched': [2499], 'NCBI': [2503], 'data': [2504], 'base': [2505], 'TurboSEQUEST': [2507], 'BioWorks': [2509], 'version': [2510], '3.2': [2511], 'Fluorescence': [2516, 2640], 'Electron': [2518], 'Microscopy—For': [2519], 'dual': [2520, 2982], 'immunofluorescence': [2521], 'staining,': [2522], 'grown': [2525], '2-well': [2527], 'chamber': [2528], 'slides': [2529], '(Nalgene,': [2530], 'Naperville,': [2531], 'IL)': [2532], 'fixed': [2534], '4%': [2536], 'paraformaldehyde': [2537], '15': [2539, 3491], '°C.': [2543, 3091, 3132, 3514, 3842], 'Cells': [2544, 3925], 'incubated': [2547, 3125, 3146, 3972], 'primary': [2549, 3127], 'overnight': [2551, 3129, 3617, 3976], '°C,': [2554, 3484, 3496, 3502, 3508, 3860, 4120], 'followed': [2555], 'incubation': [2557], 'Texas': [2559], 'Red': [2560], 'anti-rabbit': [2561, 3150], 'fluorescein': [2563], 'isothiocyanate': [2564], 'streptavidin': [2565], 'antibodies,': [2570], 'respectively': [2571], '(25Valencia': [2572], 'Matsui': [2574], 'Bondy': [2576], 'Zhou': [2578], 'Rasmussen': [2580], 'Cullen': [2582], 'Yu': [2584], 'Z.-X.': [2585], 'Moss': [2586], 'Ferrans': [2588], 'Investig.': [2591, 4311, 4356], 'Med.': [2592], '49:': [2594], '421-433Crossref': [2595], '(28)': [2598], 'skin': [2602], 'specimens': [2603], 'embedded': [2604], 'paraffin': [2606], '(26Yamaguchi': [2612], 'Kornhauser': [2618], 'Tadokoro': [2622], '20:': [2633], '1486-1488Crossref': [2634], '(157)': [2637], 'signals': [2641], 'classified': [2643], 'showed': [2648], 'green,': [2649], 'red,': [2650], 'yellow': [2652], 'fluorescence,': [2653], 'latter': [2655], 'being': [2656], 'indicative': [2657], 'colocalization': [2659, 2684, 2701], 'red': [2662], 'green': [2664], 'fluorescence': [2665, 3510, 3518], 'signals.': [2666], 'Images': [2667], 'LSM': [2672], '510': [2673], 'confocal': [2674], 'microscope': [2675], '(Zeiss,': [2676], 'Jena,': [2677], 'Germany).': [2678], 'quantification': [2681], 'signal': [2685], 'evaluated': [2687], 'under': [2688], 'equal': [2689], 'magnification,': [2690], 'intensity,': [2692], 'saturation': [2694], 'same': [2697], 'preparations': [2698], 'Zeiss': [2700], 'software.': [2702], 'For': [2703, 2724, 4063, 4219], 'condition,': [2706, 4221], '10': [2707, 3235, 3613, 3701, 4124], 'optical': [2708], 'fields': [2709], 'observed,': [2711], 'representative': [2713], 'images': [2714], 'separate': [2717], 'experiments': [2718], 'shown': [2720], 'figures.': [2723], 'electron': [2725], 'microscopy': [2726], 'immunoelectron': [2728], 'microscopy,': [2729], 'published': [2734, 3033], 'without': [2736], 'modifications': [2737], '(20Watabe': [2738, 3035, 3664, 3786, 3879], 'Expression': [2774], 'Vector': [2775], 'Cloning': [2776], 'Transfection': [2778], 'Genes—The': [2784], 'vector': [2786, 2937, 2980], 'gift': [2789], 'Toshihiko': [2792], '(Tokyo,': [2794], 'Japan).': [2795], 'DNA': [2796, 2876, 2947, 2950], 'oligonucleotides': [2797], 'gp100': [2799, 2860], 'PCR': [2800, 2894, 2930, 3437], 'Operon.': [2806], 'forward': [2808], 'primer': [2809], '5′-GGG': [2811], 'ATG': [2812], 'GAT': [2813], 'CTG': [2814, 2840, 2841], 'GTG': [2815], 'CTA': [2816], 'AAA': [2817], 'AGA': [2818], 'TGC': [2819], 'CTT': [2820, 2821], 'C-3′,': [2822], 'reverse': [2825], 'primers': [2826, 2850, 3451], '5′-CAC': [2828], 'CAG': [2829], 'CCT': [2830], 'TAA': [2831], 'GGT': [2832], 'GGC': [2833], 'TGT': [2834], 'ACC': [2835], 'ATC': [2836], 'CAG-3′': [2837], '5′-GAC': [2839], 'CCC': [2842], 'ACT': [2843], 'GAG': [2844, 2845], 'GGG': [2846], 'GCT': [2847], 'ATT-3′.': [2848], 'construct': [2854], 'vectors': [2856], 'full-length': [2859, 2968], '(pcDNA5/Pmel17fl-V5)': [2862], 'truncated': [2865], '(pcDNA5/Pmel17Δ-V5)': [2867], '468': [2872], 'amino': [2873], 'acids.': [2874], 'amplified': [2879, 3414], 'gp100-containing': [2882], 'plasmid': [2883, 2962], '(clone': [2884], 'IOH4070': [2885], 'open': [2886], 'reading': [2887], 'frame;': [2888], 'Invitrogen)': [2889], '35': [2891], 'cycles': [2892, 3486, 3528], '(27Chen': [2898], 'Szakacs': [2900], 'Annereau': [2902, 3556], 'J.P.': [2903, 3557], 'Liang': [2906], 'X.-J.': [2907], 'Nanigeni': [2910], 'C.N.': [2911], 'Hooks': [2912], 'J.J.': [2913], 'Gottesman': [2916], '2005;': [2921, 3720, 4003], '18:': [2922], '102-112Crossref': [2923], '(71)': [2926], 'subcloned': [2933], 'pcDNA5/FRT-V5-His6': [2936], 'NheI': [2941], 'BamHI': [2943], 'digestion': [2944, 3738, 3772], 'sequencing': [2948], '(the': [2949], 'Sequencing': [2951], 'Facility,': [2952], 'Bethesda).': [2954], 'plasmids': [2956], 'prepared': [2958, 3031], 'Qiagen': [2961], 'extraction': [2963], 'kit.': [2964], 'Transient': [2965], 'transfection': [2966], '(FL-Pmel17),': [2970], '(cNTF-Pmel17),': [2974], 'mock': [2977], 'FRT': [2978], 'control': [2979], 'tagged': [2983], 'V5': [2985], 'His': [2987], 'MNT-1': [2989], 'Lec2,': [2992], 'achieved': [2997], 'employing': [2999], 'Lipofectamine': [3000], '2000': [3001], 'electroporation': [3005], 'Nucleofector': [3008], 'kits': [3009], 'equipment': [3011], '(AMAXA,': [3012], 'Gaithersburg,': [3013], 'MD)': [3014], 'Immunoblotting': [3020], 'Sample': [3022], 'Preparation—For': [3023], 'immunoblotting,': [3024], 'isolated': [3028, 3345], 'fractions': [3029], 'Briefly,': [3071, 3211, 3822, 3915], 'mixed': [3075], 'sample': [3077, 3524, 3586, 4108], 'buffer': [3078, 3834, 3849, 3975, 4109], '(2×)': [3079], '2-mercaptoethanol': [3083, 4112], 'heated': [3085, 4114], '100': [3090, 3841, 4119, 4194], 'Samples': [3092, 4011], '10,': [3097], '8-16,%': [3098], '4-20%': [3100], 'transferred': [3105], 'polyvinylidene': [3107], 'difluoride': [3108], 'membranes': [3109], 'Membranes': [3111], 'casein': [3115], 'h': [3118, 3159, 3221, 3639, 3857, 4029, 4044, 4060, 4081], '23': [3120, 3249], '°C': [3121, 3218, 3936, 4084], 'After': [3133, 3479, 3966, 4099], 'washing': [3134], 'T-PBS': [3136], '(1×': [3137], 'PBS,': [3138], '1%': [3139], 'Tween': [3140], '20,': [3141], 'pH': [3142, 3233], '7.2),': [3143], 'blots': [3144], 'horseradish': [3148], 'peroxidase-linked': [3149], 'anti-mouse': [3152], 'secondary': [3153], '(Amersham': [3155, 3171, 3246, 4025, 4056], 'Biosciences)': [3156, 3953, 4026, 4057], '23°C.': [3161], 'Primary': [3162], 'detected': [3165], 'ECL': [3168], 'plus': [3169], 'system': [3170, 3428], 'Biosciences),': [3172, 3247], "supplier's": [3176, 3359], 'Sialyltransferase': [3178], 'Assays—Assays': [3179], '(28Giordanengo': [3185], 'Bannwarth': [3187], 'Laffont': [3189], 'Van': [3191], 'Miegem': [3192], 'Harduin-Lepers': [3194], 'Delannoy': [3196], 'P.': [3197], 'Lefebvre': [3198], 'Eur.': [3200], '1997;': [3203], '247:': [3204], '558-566Crossref': [3205], '(43)': [3208], 'measured': [3215], '37': [3217, 3859, 3935], 'reaction': [3226, 3322, 3848], 'comprising': [3228], '0.1': [3229], 'm': [3230], 'cacodylate': [3231], 'buffer,': [3232], '6.2,': [3234], 'MnCl2,': [3237], '0.2%': [3238], 'Triton': [3239], 'CF-54,': [3240], 'μm': [3242, 3614, 3635], 'CMP-[14C]Neu5Ac': [3243], '(1.85': [3244], 'kBq)': [3245], 'source': [3254], 'mg·ml-1': [3257], 'fetuin,': [3259], 'asialofetuin,': [3260], 'orosomucoid,': [3261], 'asialo-orosomucoid,': [3262], 'mucin': [3265], '(BSM),': [3266], 'asialo-BSM': [3268], '(Sigma)': [3269], 'acceptor': [3271], 'substrates.': [3272], 'reactions': [3274, 3333], 'stopped': [3276], 'ml': [3281, 3289], 'H2O.': [3283], 'Proteins': [3284], 'precipitated': [3286], '5%': [3291], 'phosphotungstic': [3292], 'n': [3296, 4198], 'HCl': [3297], 'filtered': [3299], 'GF/A': [3301], 'glass': [3302], 'microfiber': [3303], 'filters': [3304], '(Whatman).': [3305], 'radio-active': [3307], 'material': [3308], 'present': [3309], 'filter': [3312], 'counted': [3314], 'scintillation.': [3317], 'rate': [3319], '8': [3330], 'h.': [3331], 'All': [3332, 3413], 'triplicate.': [3337], 'Quantitative': [3338, 3418], 'Real': [3339], 'Time': [3340], 'PCRs—Total': [3341], 'RNA': [3343, 3370], 'RNeasy': [3350], 'mini': [3351], '(Qiagen,': [3353], 'Valencia,': [3354], 'Reverse': [3361], 'transcription': [3362], '200': [3366], 'ng': [3367], 'products': [3415], 'sequence-verified.': [3417], 'real': [3419], 'PCRs': [3421], 'Opticon': [3426], '(MJ': [3429], 'Research': [3430], 'Inc.,': [3431], 'Waltham,': [3432], 'hot-start': [3436], 'contained': [3439], 'double-stranded': [3441], 'DNA-binding': [3443], 'dye': [3444], 'SYBR': [3445], 'Green': [3446], '(Sigma).': [3448, 4218], 'following': [3450, 3608], 'their': [3453], 'product': [3454, 3536], 'sizes': [3455], 'used:': [3457], 'β-actin,': [3458], '5′-CCCTCCATCGTCCACCGCAAATGCTTC': [3459], '3′-GACTGCTGTCACCTTCACCGTTCCAG,': [3461], '204': [3462], 'bp;': [3463, 3470], '5′-TTCCTCACCTCCTTCTTCCTGAACTAC': [3466], '3′-TCTTCTCCAGCATAGGGTCCACATTCC,': [3468], '346': [3469], '5′-GGAAATGTCGGTGGAGTGTTCAGCAAG': [3474], '3′-AAGCAACTAACCCCCATCAAGTGCCAGACCCTC,': [3476], '356': [3477], 'bp.': [3478], '95': [3483], '40': [3485], 's': [3492, 3498, 3504], 'denaturation': [3493], '94': [3495], '30': [3497, 3503, 3932, 3942], 'annealing': [3499], '60': [3501], 'extension': [3505], '72': [3507], 'detection': [3511], '78': [3513], 'melting': [3516], 'curve': [3517, 4213], 'once': [3525], 'amplification': [3527, 3549], 'completed': [3530], 'verify': [3532], 'single': [3535], 'had': [3537], 'amplified.': [3539], 'Ct': [3541, 3582, 3589], 'defined': [3543], 'exponential': [3552], '(29Rouzaud': [3554], 'Costin': [3560], 'G.E.': [3561, 3978], '2154-2156Crossref': [3568], '(39)': [3571], 'fold': [3575, 3597], 'difference': [3576, 3598], 'calculated': [3578], 'subtracting': [3580], 'test': [3585], 'actin': [3591], 'give': [3593], 'ΔCt,': [3594], '=': [3599], '2-ΔCt.': [3600], 'Reagents': [3601], 'Enzymes—Cells': [3603], 'treated': [3605], 'reagents': [3609], '(all': [3610], 'Calbiochem):': [3612], '(30Azuma': [3618], 'Taniguchi': [3620], 'Matsumoto': [3622], 'Glycoconj.': [3624], '2000;': [3626], '301-306Crossref': [3628], 'Scholar);': [3633], 'decanoyl-Arg-Val-Lys-Arg-CMK': [3636], '3': [3638], '(31Wang': [3640], 'X.': [3641], 'Pei': [3642], '276:': [3648], '35953-35960Abstract': [3649], '(46)': [3657], 'Scholar),': [3659, 3699], 'benzyloxycarbonyl-Leu-Leu-Leu-al': [3703], '(MG132)': [3704], '(32Hoashi': [3705], '280:': [3721], '14006-14016Abstract': [3722], '(122)': [3730], 'N-Glycan': [3733], 'analyzed': [3736, 3757, 3866], 'EndoH': [3740, 3774, 3854], 'PNGaseF': [3742], 'instructions': [3747], 'England': [3749, 3776], 'Biolabs,': [3750], 'Ipswich,': [3751], 'Modifications': [3753], 'α-2,3,6,8,9-neuraminidase,': [3759], 'endo-α-N-acetyl-galactosaminidase': [3760], '(O-glycanase),': [3761], 'β1,4-galactosidase,': [3762], 'β-N-acetylglucosaminidase': [3764], '(Calbiochem),': [3765], 'Enzyme': [3771], 'Biolabs)': [3777], '35S-labeled': [3779], 'A-Sepharose': [3830], 'beads': [3831, 4024, 4055, 4093], 'denaturing': [3833], 'heating': [3836], 'Labeled': [3843], '500': [3851], 'units': [3852], '18': [3856], 'SDS-PAGE,': [3863], 'autoradiography.': [3868], 'Metabolic': [3869], 'Labeling—Metabolic': [3870], 'labeling': [3871], 'immunoprecipitation': [3873], '10-cm': [3920], 'dishes': [3921], 'until': [3922], '80%': [3923], 'confluent.': [3924], 'preincubated': [3927], 'methionine-free': [3929], 'medium': [3930, 3958], 'labeled': [3940], '0.5': [3945], 'mCi': [3946], '[35S]Met/Cys': [3948], '(Redivue': [3949], 'Pro': [3950], 'Mix;': [3951], 'Amersham': [3952], 'chased': [3955], 'methionine-plus': [3957], 'times': [3961], 'indicated': [3962], 'text.': [3965], 'harvesting,': [3967], 'washed': [3970], 'lysis': [3974], '(33Costin': [3977], 'Milac': [3987], 'A.L.': [3988], 'Petrescu': [3995], 'Lamoreux': [3997], 'M.L.': [3998], '391:': [4004], '249-259Crossref': [4005], '(57)': [4008], 'pre-cleared': [4013], 'rabbit': [4016, 4136, 4383], 'serum': [4017, 4137], 'G-Sepharose': [4020, 4054], 'fast': [4022], 'flow': [4023], '4°C.The': [4031], 'supernatants': [4032, 4069], 'collected': [4034], 'immunoprecipitated': [4036, 4071, 4133], 'αPEP13h': [4039, 4076, 4394], '4°C,': [4046], 'immunocomplexes': [4048, 4089], '4°C.': [4062], 'double': [4064], 'immunoprecipitation,': [4065], 'recovered': [4067, 4087], 'them': [4072], 'again': [4073, 4090], 'protein-G': [4092], 'continued': [4095], 'protocol.': [4098], 'washing,': [4100], 'final': [4102], 'pellets': [4103, 4190], 'suspended': [4105], 'SDS': [4107], '(Sigma),': [4113], '8-16%': [4126], 'Control': [4130], 'parallel.': [4142], 'Lectin': [4143], 'Staining—Lectin': [4144], 'blot': [4145], 'digoxigenin-labeled': [4148], 'lectins': [4149], '(Roche': [4150], 'Applied': [4151], 'Science)': [4152], 'Melanin': [4160], 'Content': [4161], 'Assay—Melanin': [4162], 'determined': [4165], '(34Virador': [4169], 'Anal.': [4177], '270:': [4180], '207-219Crossref': [4181], '(106)': [4184], 'brief,': [4188], 'dissolved': [4192], 'NaOH,': [4199], 'concentrations': [4202], 'quantitated': [4204], 'absorbance': [4206], '405': [4208], 'nm': [4209], 'standard': [4212], 'expressed': [4226], 'nanograms': [4228], 'divided': [4231], 'total': [4233], 'concentration': [4235], 'micrograms.': [4237], 'Values': [4238], 'percentage': [4244], 'controls.': [4249], 'experiment': [4251], 'repeated': [4253], 'times.': [4257], 'Specifically': [4259], 'Detects': [4260], 'iPmel17—The': [4261], '393-414': [4268], '(Fig.': [4269], '1A)': [4270], '(35Kim': [4277], 'Youn': [4279], 'Heng': [4281], 'Shi': [4283], 'X.M.': [4284], 'Tsui': [4285], 'L.C.': [4286], 'Lee': [4287, 4306], 'Z.H.': [4288], 'Pickard': [4289], 'R.T.': [4290], '1996;': [4296, 4313], '42-48Crossref': [4298], '(9)': [4301], '36Bailin': [4304], 'S.K.': [4307], 'Spritz': [4308], 'R.A.': [4309], 'Dermatol.': [4312, 4357], '106:': [4314], '24-27Abstract': [4315], '(17)': [4321], 'would': [4325], 'expected': [4327], 'recognize': [4329], 'splice': [4334, 4345], 'recently': [4341], 'minor': [4343], 'third': [4344], 'variant': [4346], '(37Nichols': [4347], 'S.E.': [4348], '121:': [4359], '821-830Abstract': [4360], '(29)': [4368], 'assess': [4372], 'antisera': [4384], 'reactivity': [4388], 'patterns': [4389], 'characterized': [4393], '(which': [4395]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2057452550', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2025-01-06T08:30:08.323654', 'created_date': '2016-06-24'}
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