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'found': [21], 'to': [22, 34, 39, 62, 284, 289, 304], 'exert': [23], 'biological': [24], 'effects': [25], 'in': [26, 47, 60, 66, 120, 176, 201, 240, 262, 272, 295, 348, 362, 375, 388], 'vitro.': [27], 'However,': [28], 'it': [29, 281], 'not': [31], 'yet': [32], 'clear': [33], 'which': [35], 'extent': [36], 'they': [37], 'contribute': [38], 'pathogenesis': [41, 390], 'as': [42, 134], 'coeliac': [43, 57, 81, 106, 166, 207, 215, 235, 310, 329, 364, 392], 'occurs': [45], 'also': [46, 244, 294], 'patients': [48, 82, 102, 131, 167, 208, 216, 330, 365], 'with': [49, 83, 103, 157, 175, 257], 'humoral': [50, 386], 'immunodeficiency.': [51], 'We': [52], 'have': [53, 87], 'previously': [54], 'shown': [55], 'that': [56, 313], 'binds': [59], 'vivo': [61, 353], 'extracellularly': [63, 245], 'located': [64], 'TG2': [65, 137, 144, 258, 357], 'the': [67, 73, 153, 170, 202, 247, 276, 286, 290, 305, 314, 376, 382, 389], 'jejunum': [68, 203, 306], 'extraintestinal': [70], 'tissues': [71], 'of': [72, 91, 149, 204, 210, 266, 275, 308, 334, 355, 367, 385, 391], 'patients.': [74], 'In': [75, 352], 'this': [76], 'study': [77], 'we': [78], 'investigated': [79], 'whether': [80], 'deficiency': [85], '(IgAD)': [86], 'an': [88], 'targeting': [90, 354], 'TG2.': [92], 'Methods:': [93], 'Unfixed': [94], 'frozen': [95], 'small-intestinal': [96], 'biopsy': [97], 'sections': [98, 154], 'from': [99, 127, 163], '18': [100, 233, 277], 'untreated': [101], 'IgAD': [104, 130, 206, 214, 234, 278, 309, 328, 363], '(total': [108], 'serum': [109, 160], 'IgA<0.05g/l,': [110], 'age': [111], '2–37': [112], 'years)': [113], 'evaluated': [115], 'multi-colour': [117], 'immunofluorescence': [118], 'for': [119], 'situ': [121, 177], 'IgA,': [122, 180], 'IgG': [123, 181, 267, 325, 336], 'IgM.': [125], 'Sections': [126], '5': [128], 'non-coeliac': [129], 'used': [133], 'controls.': [135, 212, 263, 296], 'Jejunal': [136], 'was': [138, 282], 'recognised': [139], 'monoclonal': [141], 'activity': [145], 'labelling': [146], 'incorporation': [148], 'Texas-red': [150], 'cadaverine.': [151], 'Further,': [152], 'incubated': [156], 'anti-TG2': [161, 185, 299, 338, 343], 'competent': [165], '(n=3)': [168], 'binding': [171, 316], 'sites': [172, 317], 'compared': [174], 'immunoglobulins.': [178, 326], 'Serum': [179], 'IgM': [183, 238, 254, 323, 341, 361, 370], 'measured': [188], 'ELISA.': [190], 'Results:': [191], 'containing': [195], 'plasma': [196, 220, 241], 'cells': [197, 242], 'completely': [199], 'absent': [200, 261], '16/18': [205], 'all': [211], 'Two': [213], 'had': [217, 331], 'some': [218], 'cells,': [221], 'but': [222, 280], 'no': [223], 'extracellular': [224], 'deposition': [226], 'or': [227, 324], 'circulating': [228, 335], 'anti-TG2.': [231], 'All': [232, 327], 'samples': [236, 287, 307], 'contained': [237], 'both': [239], 'along': [246], 'surface': [248], 'crypt': [250], 'basement': [251], 'membranes.': [252], 'These': [253, 369], 'deposits': [255, 265], 'co-localised': [256], 'Similar': [264], 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